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22 results on '"Luccioli, Filippo"'

5. Discrepancy between subjective symptoms, objective measures and disease activity indexes: the lesson of primary Sjögren's syndrome

Author

Alunno, Alessia, Bartoloni, Elena, Valentini, Valentina, La Paglia, Giuliana Maria Concetta, Valentini, Eleonora, Leone, Maria Comasia, Marcucci, Elisa, Cafaro, Giacomo, Bonifacio, Angelo Francesco, Luccioli, Filippo, and Gerli, Roberto

Subjects
Lacrimal Apparatus, Reproducibility of Results, Prognosis, Severity of Illness Index, Xerostomia, Salivary Glands, Decision Support Techniques, Sjogren's Syndrome, Humans, Predictive Value of Tests, Quality of Life, Salivation, Tears, Terminology as Topic, Xerophthalmia, Patient Reported Outcome Measures
Abstract

Mucosal dryness is a key clinical feature in primary Sjögren's syndrome (pSS) and its assessment relies on both objective measurement of residual secretion and subjective symptoms reported by patients. However, while the objective assessment and grading of glandular dysfunction can be easily performed, the spectrum of clinical symptoms encompassed by the terms 'dry eye' and 'dry mouth' is wide and heterogeneous. Therefore, patient reported outcomes (PROs) for dryness in pSS poorly correlate with the amount of glandular secretion. In addition, subjective dryness is not correlated with the severity of systemic disease and severely affects the patient quality of life even in presence of active extraglandular manifestations. The purpose of this review article is to provide an overview of glandular dysfunction in pSS as well as the impact of discrepancy between objective assessment, subjective symptom and extraglandular disease activity on disease management.

Published
2018

7. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: the STARTER study

Author

Filippou, Georgios, primary, Sakellariou, Garifallia, additional, Scirè, Carlo Alberto, additional, Carrara, Greta, additional, Rumi, Federica, additional, Bellis, Emanuela, additional, Adinolfi, Antonella, additional, Batticciotto, Alberto, additional, Bortoluzzi, Alessandra, additional, Cagnotto, Giovanni, additional, Caprioli, Marta, additional, Canzoni, Marco, additional, Cavatorta, Francesco Paolo, additional, De Lucia, Orazio, additional, Di Sabatino, Valentina, additional, Draghessi, Antonella, additional, Farina, Ilaria, additional, Focherini, Maria Cristina, additional, Gabba, Alessandra, additional, Gutierrez, Marwin, additional, Idolazzi, Luca, additional, Luccioli, Filippo, additional, Macchioni, Pierluigi, additional, Massarotti, Marco Sergio, additional, Mastaglio, Claudio, additional, Menza, Luana, additional, Muratore, Maurizio, additional, Parisi, Simone, additional, Picerno, Valentina, additional, Piga, Matteo, additional, Ramonda, Roberta, additional, Raffeiner, Bernd, additional, Rossi, Daniela, additional, Rossi, Silvia, additional, Rossini, Paola, additional, Scioscia, Crescenzio, additional, Venditti, Carlo, additional, Volpe, Alessandro, additional, and Iagnocco, Annamaria, additional

Published
2018
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9. Ultrasound-detected tenosynovitis independently associates with patient-reported flare in patients with rheumatoid arthritis in clinical remission: results from the observational study STARTER of the Italian Society for Rheumatology

Author

Bellis, Emanuela, primary, Scirè, Carlo Alberto, additional, Carrara, Greta, additional, Adinolfi, Antonella, additional, Batticciotto, Alberto, additional, Bortoluzzi, Alessandra, additional, Cagnotto, Giovanni, additional, Caprioli, Marta, additional, Canzoni, Marco, additional, Cavatorta, Francesco Paolo, additional, De Lucia, Orazio, additional, Di Sabatino, Valentina, additional, Draghessi, Antonella, additional, Filippou, Georgios, additional, Farina, Ilaria, additional, Focherini, Maria Cristina, additional, Gabba, Alessandra, additional, Gutierrez, Marwin, additional, Idolazzi, Luca, additional, Luccioli, Filippo, additional, Macchioni, Pierluigi, additional, Massarotti, Marco Sergio, additional, Mastaglio, Claudio, additional, Menza, Luana, additional, Muratore, Maurizio, additional, Parisi, Simone, additional, Picerno, Valentina, additional, Piga, Matteo, additional, Ramonda, Roberta, additional, Raffeiner, Bernd, additional, Rossi, Daniela, additional, Rossi, Silvia, additional, Rossini, Paola, additional, Sakellariou, Garifallia, additional, Scioscia, Crescenzio, additional, Venditti, Carlo, additional, Volpe, Alessandro, additional, Matucci-Cerinic, Marco, additional, and Iagnocco, Annamaria, additional

Published
2016
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10. La sindrome di Sjogren

Author

BARTOLONI BOCCI, Elena, Luccioli, Filippo, Biscontini, D., and Gerli, Roberto

Published
2009

13. Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome

Author

Shovman, O., Sherer, Y., Gilbourd, B., Gerli, Roberto, BARTOLONI BOCCI, Elena, DELLE MONACHE, Francesco, Luccioli, Filippo, and Shoenfeld, Y.

Subjects
Sjogren's Syndrome, Bacterial Proteins, Chaperonins, Case-Control Studies, Immunoglobulin G, Humans, Enzyme-Linked Immunosorbent Assay, Female, Chaperonin 60, Autoantibodies
Abstract

Heat shock proteins are highly conserved immunodominant antigens found in various species. Humoral immune responses to mycobacterial HSP65 and human HSP60 have been established in a number of human autoimmune diseases.To assess the prevalence of antibodies to HSP60 kDa and HSP65 kDa in patients with Sjögren's syndrome as compared to normal subjects.Thirty-seven patients with SS were compared with normal controls. The antibodies against human HSP60 were measured by the Anti-Human (IgG/IgM) HSP60 ELISA kit. IgGs and IgMs to mycobacterial HSP65 were determined using an enzyme-linked immunosorbent assay with mycobacterial recombinant HSP65 antigens.The levels of both anti-HSP60 and -HSP65 were lower in patients compared with controls. IgG autoantibodies to HSP60 were significantly different between groups: 162 +/- 55.1 ng/ml in controls versus 112.3 +/- 30.6 ng/ml in SS patients (P0.001). The levels among controls of anti-HSP65 IgM isotype were also significantly higher than among the SS patients: 111.6 +/- 33.4 U/ml versus 96.1 +/- 8.9 U/ml (P= 0.01).The results of the present study show that the levels of different isotypes of anti- HSP60 and HSP65 antibodies were lower in patients with SS than in normal subjects. Additional studies in larger patient populations are required to evaluate the prevalence of these autoantibodies in SS patients.

Published
2005

15. A multi-dimensional questionnaire quantifying quality of life in elderly osteoporotic women: the Italian Triple-Q Osteoporosis Study

Author

Maggio, Dario, primary, Ruggiero, Carmelinda, additional, Ercolani, Sara, additional, Macchiarulo, Maria Carmela, additional, Palmari, Nicola, additional, Luccioli, Filippo, additional, Andreani, Sonia, additional, Mariani, Angela, additional, Costanzi, Emanuela, additional, Cherubini, Antonio, additional, Luchetti, Maurizio, additional, Zampi, Elena, additional, Girasole, Giuseppe, additional, Bianchi, Gerolamo, additional, Rossini, Maurizio, additional, Cepollaro, Chiara, additional, Sartori, Leonardo, additional, Minisola, Salvatore, additional, and Gonnelli, Stefano, additional

Published
2010
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17. Accelerated atherosclerosis in systemic lupus erythematosus and other connective tissue diseases.

Author

Bocci, Elena Bartoloni, Luccioli, Filippo, Angrisani, Claudio, Moscatelli, Sheila, Alunno, Alessia, and Gerli, Roberto

Subjects
ATHEROSCLEROSIS, SYSTEMIC lupus erythematosus, CONNECTIVE tissue diseases, AUTOIMMUNITY, CARDIOVASCULAR diseases, RHEUMATISM
Abstract

Connective tissue diseases are associated with increased morbidity and mortality related to a higher rate of cardiovascular events and higher prevalence of subclinical atherosclerosis. Atherosclerosis is now considered a multifactorial process where autoimmunity and chronic inflammation play an important pathogenic role. In systemic autoimmune rheumatic diseases in general, and in systemic lupus erythematosus in particular, atherosclerosis cannot be explained by traditional cardiovascular risk factors alone. Cellular and humoral mechanisms, together with specific factors associated with the disease itself and/or its treatments, have been advocated to explain the acceleration of arterial wall organic damage in these patients. Endothelial dysfunction, carotid intima-media thickness and plaque evaluations provide accurate detection of atherosclerotic process at a preclinical stage, before appearance of clinical disease, allowing preventive measure introduction with the aim to modify the cardiovascular risk in subjects with systemic autoimmune rheumatic diseases. [ABSTRACT FROM AUTHOR]

Published
2007
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18. Ultrasound-Detected Tenosynovitis Independently Associates with Flare in Patients with Rheumatoid Arthritis in Clinical Remission

Author

Bellis, Emanuela, Carrara, Greta, Scire, Carlo Alberto, Bortoluzzi, Alessandra, Batticciotto, Alberto, Adinolfi, Antonella, Cagnotto, Giovanni, Caprioli, Marta, Canzoni, Marco, Cavatorta, Francesco, Ceccarelli, Fulvia, Lucia, Orazio, Di Sabatino, Valentina, Draghessi, Antonella, Filippou, Georgios, Farina, Ilaria, Focherini, Maria Cristina, Frallonardo, Paola, Gabba, Alessandra, Gattamelata, Angelica, Gutierrez, Marwin, Luca Idolazzi, Luccioli, Filippo, Macchioni, Pierluigi, Massarotti, Marco, Mastaglio, Claudio, Menza, Luana, Mirabelli, Giulia, Muratore, Maurizio, Parisi, Simone, Picerno, Valentina, Piga, Matteo, Ramonda, Roberta, Raffeiner, Bernd, Rossi, Daniela, Rossini, Paola, Sakellariou, Garifallia, Scioscia, Crescenzio, Venditti, Carlo, Iagnocco, Annamaria, and Matucci-Cerinic, Marco

Subjects
rheumatoid arthritis

20. The prevalence and relevance of traditional cardiovascular risk factors in primary Sjögren's syndrome.

Author

Bartoloni E, Alunno A, Valentini V, Valentini E, La Paglia GMC, Leone MC, Cafaro G, Marcucci E, Bonifacio AF, Luccioli F, and Gerli R

Subjects
Atherosclerosis diagnosis, Atherosclerosis immunology, Diabetes Mellitus epidemiology, Dyslipidemias epidemiology, Humans, Hypertension epidemiology, Obesity epidemiology, Prevalence, Prognosis, Risk Assessment, Risk Factors, Sjogren's Syndrome diagnosis, Sjogren's Syndrome immunology, Smoking adverse effects, Smoking epidemiology, Atherosclerosis epidemiology, Sjogren's Syndrome epidemiology
Abstract

Accelerated atherosclerosis is a distinct feature of some inflammatory and autoimmune disorders and several specific autoimmune mechanisms and persistent inflammation have been identified to exert a pivotal role in precocious atherosclerotic damage in these disorders. Although increased atherosclerotic risk has been well established in some rheumatic autoimmune systemic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, reliable data regarding the prevalence and pathogenetic mechanisms associated with increased atherosclerotic damage in primary Sjögren's syndrome are scarse. Indeed, primary Sjögren's syndrome is an autoimmune disorder characterised by chronic inflammation and autoimmune dysregulation that shares many pathogenic mechanisms and clinical features with systemic lupus erythematosus and rheumatoid arthitis. Higher prevalence of subclinical atherosclerosis has been observed in primary Sjögren's syndrome patients and recent population-based studies demonstrated an increased risk of cardiovascular events in these patients in comparison to general population. Among mechanisms associated with atherosclerotic damage, the prevalence and the role of traditional cardiovascular risk factors have been poorly investigated. In particular, the issue of whether the presence of these cardiovascular risk factors is associated with an increased risk of cardiovascular events needs to be further explored.

Published
2018

21. Correlation between clinimetric approach and German US7 score in rheumatoid arthritis patients treated with tocilizumab: a pilot study.

Author

Terenzi R, Santoboni G, Bartoloni E, Alunno A, Luccioli F, and Gerli R

Subjects
Aged, Arthritis, Rheumatoid physiopathology, Cross-Sectional Studies, Female, Humans, Joints diagnostic imaging, Joints physiopathology, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Quality of Life, Reproducibility of Results, Severity of Illness Index, Surveys and Questionnaires, Time Factors, Treatment Outcome, Ultrasonography, Antibodies, Monoclonal, Humanized therapeutic use, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Health Status Indicators, Joints drug effects
Published
2015

22. Cardiovascular disease in systemic sclerosis.

Author

Cannarile F, Valentini V, Mirabelli G, Alunno A, Terenzi R, Luccioli F, Gerli R, and Bartoloni E

Abstract

Cardiovascular (CV) system involvement is a frequent complication of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). It still remains unclear if a premature atherosclerosis (ATS) occurs even in systemic sclerosis (SSc). Although microvascular disease is a hallmark of SSc, in the last few years a number of studies highlighted a higher prevalence of macrovascular disease in SSc patients in comparison to healthy individuals and these data have been correlated with a poorer prognosis. The mechanisms promoting ATS in SSc are not fully understood, but it is believed to be secondary to multi-system organ inflammation, endothelial wall damage and vasculopathy. Both traditional risk factors and endothelial dysfunction have been proposed to participate to the onset and progression of ATS in such patients. In particular, endothelial cell injury induced by anti-endothelial antibodies, ischemia/reperfusion damage, immune-mediated cytotoxicity represent the main causes of vascular injury together with an impaired vascular repair mechanism that determine a defective vasculogenesis. Aim of this review is to analyse both causes and clinical manifestations of macrovascular involvement and ATS in SSc.

Published
2015
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