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1. Renovascular hypertension in pediatric patients: update on diagnosis and management

Author

Letícia Bitencourt, Juliana Lacerda de Oliveira Campos, Ana Luisa Pedrosa, Filipe Ji Jen Lin, Diego Ferreira Silva, Ana Cristina Simões e Silva, and Lucas Teixeira de Oliveira Dias

Subjects
Nephrology, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Fibromuscular dysplasia, 030204 cardiovascular system & hematology, Renal Artery Obstruction, Revascularization, Magnetic resonance angiography, Renovascular hypertension, 03 medical and health sciences, Renal Artery, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Humans, Renal artery, Child, medicine.diagnostic_test, business.industry, Digital subtraction angiography, medicine.disease, Stenosis, Hypertension, Renovascular, Pediatrics, Perinatology and Child Health, Cardiology, business, Angioplasty, Balloon
Abstract

Renovascular hypertension (RVH) is defined as an elevated blood pressure caused by kidney hypoperfusion, generally as a result of anatomic stenosis of the renal artery with consequent activation of the Renin Angiotensin-Aldosterone System. The main causes include genetic and inflammatory disorders, extrinsic compression, and idiopathic alterations. RVH is often asymptomatic and should be suspected in any child with refractory hypertension, especially if other suggestive findings are present, including those with severe hypertension, abdominal bruit, and abrupt fall of glomerular filtration rate after administration of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. There is a consensus that digital subtraction angiography is the gold standard method for the diagnosis of RVH. Nevertheless, the role of non-invasive imaging studies such as Doppler ultrasound, magnetic resonance angiography, or computed tomographic angiography remains controversial, especially due to limited pediatric evidence. The therapeutic approach should be individualized, and management options include non-surgical pharmacological therapy and revascularization with percutaneous transluminal renal angioplasty (PTRA) or surgery. The prognosis is related to the procedure performed, and PTRA has a higher restenosis rate compared to surgery, although a decreased risk of complications. This review summarizes the causes, physiopathology, diagnosis, treatment, and prognosis of RVH in pediatric patients. Further studies are required to define the best approach for RVH in children.

Published
2021
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2. Saúde do Homem

Author

Luiz Gerson Gonçalves Neto, Gustavo Soares Gomes Barros Fonseca, Izabely Lima Assunção, Cinthya Letícia Silva Ribeiro, Luiza Helena Everton Coelho, Hosana da Luz Bezerra Leite dos Santos, Heitor Campos Damião Daher, Hyasmin Bomfim Paranhos, Ana Clara Ávila Gomes, Marcela Victória Goulart Melo de Oliveira, Maize Lúcia de Oliveira, Karolayne Joyce Oliveira, Nayara Emili Ribeiro Silva, Gabriela Roque Pereira, Erika Araújo dos Santos, Júlia Beatriz Pinto Araujo, Lucas Parizi Alves, Tamilys Emanoelly de Lima, Natalia Maria Figueira Donadio, Mury-Ane Urzêda Moura, Lucas Costa de Aranda Lima, Mariana Sausen Basso, Monica Micheli Alexandre, Rosselyn Gimenes Baisch, Victor Fajardo Bortoli, Suélen Stefanoni Brandão, Rafaela Costa de Aranda Lima, Artur Mota Ferreira, Maria fernanda Felizardo Melo, Laís Assunção Vilefort, Amanda Brandão Lopes, Luiza Souto Borges Baeta, Lorena Araújo de Alcântara, Raphaela freire de Sá, Priscilla de Oliveira Reis, Isabella Nacur Pinheiro, Dândara Larisse Fagundes Araújo, Rubria Paiva Santos, Ana Beatriz Fonsêca Souza de Jesus, Luiza Nacur Pinheiro, Felipe Jean de Souza Ferreira, Lais Assunção Vilefort, Amanda Prates de Oliveira, Letícia Gabrielly R. Mata, Moisés Gustavo da Cunha, Daniel Matos Ribeiro, Felipe Frederico Ozanan Pereira, Isabella da Silva Espíndola, Fabrício Veiga Gonzaga, José Renato Schelini, Ana Júlia Rodrigues Barbosa, TÁCIO RAFAEL SANTOS BATISTA, Aylla Corrêa Gonçalves, Estevão Mendonça Farias, Rodrigo De Martin Almeida, Jade Proêncio Justo, Felipe Mazocoli Felizardo, Lívia Nóbrega Ribeiro, Lucas Guerra Gonze, Luisa Rodrigues Garcia, Nair dos Santos Jorge, Vinícius Cavalari Rinaldi, Aline Araújo Cordeiro, André Corrêa de Araújo Amorim, José Victor Nunes Coutinho, Maria Clara Cunha Cordeiro, Matheus Castelo Branco Falcão Albuquerque, Nathalia Alves da Silva, Rayanne da Cunha Mendes, Victor Hugo Oliveira Martins Coelho, Esteffany Vaz Pierot, Aline Rafael de Sousa Ibiapina, Jurandir carvalho de Lacerda Neto, Wellington Sousa Morais, Igor Dutra Lima, Gedivan Pereira de Gois, Camila França da Silveira e Sousa, Pedro Luís Skrapec Borelli, Davila Fernanda Rodrigues Fonseca, Arthur Rickson Nunes Dias, José da Silva Junior, Heloisa Rolin Marques Lima, Lais Assunçao Vilefort, Rosimar Gonçalves Xavier Pereira, Meire Astorfina de Vasconcelos, Pâmela Graça Quintão Ferreira, Eduardo Expedito Valeriano Batista, Fernanda Amparo Ribeiro, Plínio Aristeu Mól Baião, Lays Teixeira de Paula, Paula Maria Lara Maia, Alef Cesar Pinto, Bernardo Tolentino de Carvalho, Luana Girasole Bretas, Lísia Soares Silva, Leticya Ribeiro Rocha, Julia Lima Soares de Paula, José Elias Costa da Silveira, Maickon Henrique Speranza, Laura Simões Bernardes, Luis Henrique Souto do Amaral, Rafael Batista de Souza, Rodrigo Vilela de Oliveira, Mariane Luzia Arantes, Isabela Santos Lacerda, Max de Oliveira Martucheli, Francisco de Paula Xavier Neto, Ewellyn Priscila Fernandes, Janaina Laila Rodrigues Castilho, Simone Fernandes Nogueira, Priscila Cavalieri Masson, Patricia Pimenta Nunes, Beatriz Baldon Coelho, Giovana Baldon Coelho, Gabryella Naves, Gabrielli Zanus, Tássio Martinho Valente Ribeiro, Laura Machado Barbosa Junqueira, Julia Cristina Peres Rodrigues Gomes, Camila Souza Milano, Alex de Souza Dipe, Carolina Gomes Madeira, Fernanda Paula Atavila, Ana Elisa Pereira Lopes, Júlia Belo de Oliveira, Isabella Mendes Monteiro de Barros, Ana Carolina Marinho Coelho Vasconcelos, Isabella Alvim Werner, Rogério Wilson Brandão Fernandes, Mariana Carneiro Takeuchi, Amanda Pinheiro Lima, Ingrid Fátima Martins Vasconcelos, Vitória Lima Franco, Thaís Ribeiro Dini, Isa Depe, Luiz Eduardo Penna Silveira, Isabela Benevenuto Teixeira, Luísa Pandelo Lima, Paula de Souza Bernardes, Lara Ferreira Camacho, Anne Ávila Santarém, Ludmilla Fernanda Alves de Faria, Bruna Pereira Silva, Luiz Paulo Cotta Garcia, Flávia de Souza Bernardes, Sarah de Souza Pires, Laura Bastos Couri de Melo, Mariana Moraes Pacheco, Fernanda Drumond Rabelo, Mateus Murad Magalhães Oliveira, Renata Fernandes Nogueira, João Paulo Rossi de Meneses Vargas, Natália Rodrigues Gomes de Assis, Julia Miranda Brescia Fonseca, Luiza Fontes e Souza, Diego Câmara Morais, Bruno Magalhães Gomes Macedo, Victor Marccel Lino Alves, Ramon Ramos de Souza Gonzaga, Rodrigo Tavares Gonçalves, Pedro Guimarães de Azevedo, Felippe Amaral Simões, Luis Gustavo Fernandes Dias, Lucas Antonio de Lacerda e Silva, Thales Pessoa Carneiro, Guilherme Arriel Caetano, Larissa Rezende Lima Pereira, MAYRA LOURES DE OLIVEIRA, ADRIANE RAMALHO DA SILVA, Darley Souza de Oliveira, EDUARDO YOSHIHIRO OUE, FABIANA BORGES MANZO, FABIANO PINHEIRO RIBEIRO JÚNIOR, FERNANDA CARDOSO VIEIRA, JEFFERSON MATHEUS NUNES DUTRA, JHONATAS NEPOMUCENO SILVA, JULIANA CARDOSO VIEIRA, LUANA HOHELVERGER DE OLIVEIRA, MIRELLA MENDES CALHEIROS, TALITA APARECIDA ROCHA CABRAL, Tiago Luis Machado Miranda, Eriane Damasia Faria de Almeida Abreu, Verônica de Araújo Libânio Costa, Rafaela Ribeiro de Almeida, Mariana Cavaliere Batista e Silva, Paloma Álister Vilela da Silva, Stella Silva Rosa, Rafael Abreu e Sá, Vitória Gabriela Meira Virginio Aranha, Emilene Caroline Gonçalves Rodrigues, Luana Antunes Brogiatto, Marjory Bicheri, Mayara Gabriela Pereira de Carvalho, Cristina Guilherme de Almeida, Leonardo Fernandes de Faria, Ana Luísa Barbosa Amaral, Henrique Gonçalves de Melo, Ingrid Silva Costa, Kássia Burini, Laura Gregório Pires, Natália Isabela Jales Tranin, Lucas Rodrigues Ruback, Gabriela Vieira Souto, Marcelo Augusto de Almeida Nogueira, Luis Henrique Dias Lima, Lucas Teixeira de Oliveira Dias, Anna Carolina Orsini Arman, Daira de Araújo TEodoro, Edison Daniel Schneider Monteiro, Hendrick Yuji Ivanaga, José Willia Borges Osório, Lorena Martinez Corso, Lucas Henrique Sanchez Cavalheiro, LuÍsa Riccetto, Marina bertolini matheus, Mauro renato amorim barros, pedro benedetti guedes Galvão, Stefani Z Monção, Victor GOnçalves de LIma, Vitor Hideki Nakamura de Sousa, Caroline de Oliveira Pedro, Carolina Martins Figueiredo, Flávio Antonio Alves, Gustavo Bosi Radicchi, Karen Giulia Rodrigues, Luísa Ricetto, Marina Bertolini Matheus, Stefani Zaqué Monção, Thiago Figueira Furtado, Mariana Silva Santos, Luisa Lago de Souza, Leonardo Tadeu Souza Neves, Luis Filipe Souza Trindade, Lays Nascimento Leão, Ana Luiza Ledro Nagem, Rilmara Carolina Pereira do Nascimento, Marina Mattar de Melo Miranda Salim, Ana Flavia Barbosa Matias, Sylvia Bolina Azevedo, Thales Henriques de Lima, Gustavo Pantuza Gonçalves Penido, Fredstone Scofield Silva, Anna Luiza Horta Vitória, Nadir Alves de Oliveira Neta, Débora Mendes do Carmo, Sofia de Melo Ramos, Ana carolina Lopes Pereira, Thiago Moura Gonçalves, Matheus de Oliveira Santos, Luiza da Nóbrega Tobias, Thiago Vinícius de Souza Ferreira, Gabriela Pacheco Barbosa Moreira, Mariana Barbedo de Paula Dutra, Isabelle Lolli Pascoal, Gustavo Henrique Silva Sidrim, Frederico Noboro Figueiredo Nakagawa, Júlia Fraga Vieira, Laura Marques santos, Marcella Barboza Sampaio, Luige Alexandre Tessaro de Backer, Júlia Tôrres Russo Miranda, Júlia Barreto Reis, Bárbara Poggiali Gomes, Ágatha Barbosa Rocha, Gustavo Lopes de Oliveira, LORELLA MIRANDA AURICCHIO, ANDRÉ MACHADO LEITE DE BARROS, REMO JOGAIB SALCIARINI, Ana Victória Pinho de Carvalho Pascal, Sarah Barreto Ramos Pereira, Rafael Rodrigues Ferraz Viana, Brunna Aquino de Souza Pinto, and Guilherme Canabrava Rodrigues Silva

Abstract

Com o aumento significativo da importância das neoplasias no perfil de mortalidade da populacao brasileira, o Ministerio da Saude propos a Politica Nacional de Prevencao e Controle do Câncer, cujo objetivo e reduzir a incidencia e a mortalidade por câncer no Brasil atraves da conscientizacao da populacao quanto aos fatores de risco, promovendo a deteccao precoce dos cânceres passiveis de rastreamento e propiciem o acesso a um tratamento equitativo e de qualidade em todo territorio nacional.Sua incidencia vem apresentando um aumento significativo apos a introducao de novos metodos diagnosticos e o aumento da expectativa de vida da populacao masculina. Diante do exposto, foi realizado um Projeto de Extensao no Centro de Atencao ao Idoso no municipio de Barbalha com o objetivo de prevenir este tipo de neoplasia, dando as informacoes necessarias para a conscientizacao dos beneficios da prevencao.

Published
2021
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3. Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine

Author

Valéria Nayara Gomes Mendes de Oliveira, Thais de Oliveira Rodrigues, Lucas Teixeira de Oliveira Dias, Luis Fernando Viana Furtado, Vivian Jordania da Silva, and Élida Mara Leite Rabelo

Subjects
0301 basic medicine, Ancylostoma, Genotype, Stool sample, Human intestine, Necator americanus, 030231 tropical medicine, Zoology, lcsh:Medicine, Article, Ancylostomiasis, Necatoriasis, Feces, 03 medical and health sciences, 0302 clinical medicine, Environmental biotechnology, parasitic diseases, Animals, Humans, lcsh:Science, Hookworm infection, Genotyping, Molecular identification, Human feces, Multidisciplinary, biology, fungi, lcsh:R, DNA, Helminth, biology.organism_classification, Intestines, 030104 developmental biology, lcsh:Q, Evolutionary developmental biology, Ancylostoma caninum, Brazil
Abstract

Hookworms are intestinal parasites that cause major public health problems, especially in developing countries. To differentiate eggs from different hookworm species, it is necessary to use molecular methodologies, since the eggs are morphologically similar. Here, we performed the molecular identification of single hookworm eggs from six Brazilian states. Of the 634 eggs individually analyzed, 98.1% (622/634) represented Necator americanus, and surprisingly, 1.9% (12/634 eggs from the same patient) represented Ancylostoma caninum. DNA analysis of the A. caninum-positive stool sample revealed no contamination with animal feces. This is the first report of the presence of A. caninum eggs in human feces, which may have a direct implication for the epidemiology of hookworm infection caused by this species. This suggests the need for special attention regarding prophylaxis, as different reservoirs, previously not described, may have great relevance for the spread of A. caninum.

Published
2020
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