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7 results on '"Lucas B. Fallot"'

2. Structure-Activity Studies of 1

Author

Lucas B, Fallot, R Rama, Suresh, Courtney L, Fisher, Veronica, Salmaso, Robert D, O'Connor, Noy, Kaufman, Zhan-Guo, Gao, John A, Auchampach, and Kenneth A, Jacobson

Subjects
Allosteric Regulation, Adenosine A3 Receptor Agonists, Receptors, Purinergic P1, Humans, Animals, Caco-2 Cells, Amines, Rats
Abstract

We previously reported 1

Published
2022

4. Characterization of Dual-Acting A

Author

Courtney L, Fisher, Lucas B, Fallot, Tina C, Wan, Robert F, Keyes, R Rama, Suresh, Amy C, Rothwell, Zhan-Guo, Gao, John D, McCorvy, Brian C, Smith, Kenneth A, Jacobson, and John A, Auchampach

Abstract

The A

Published
2022

5. Structure-Activity Studies of 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators

Author

Lucas B. Fallot, R. Rama Suresh, Courtney L. Fisher, Veronica Salmaso, Robert D. O’Connor, Noy Kaufman, Zhan-Guo Gao, John A. Auchampach, and Kenneth A. Jacobson

Subjects
Allosteric Regulation, Purinergic P1, Adenosine A3 Receptor Agonists, Drug Discovery, Receptors, Molecular Medicine, Humans, Animals, Caco-2 Cells, Amines, Rats, Receptors, Purinergic P1
Published
2022

6. Water Mediated Wittig Reactions of Aldehydes in the Teaching Laboratory: Using Sodium Bicarbonate for the in Situ Formation of Stabilized Ylides

Author

B. Mikael Bergdahl, Jeffrey L. Gustafson, Lucas B. Fallot, and Michael J. B. Kelly

Subjects
Green chemistry, chemistry.chemical_classification, Sodium bicarbonate, Aqueous solution, Base (chemistry), 010405 organic chemistry, Infrared spectroscopy, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Education, chemistry.chemical_compound, chemistry, Reagent, Wittig reaction, Organic chemistry, Alkene formation
Abstract

The synthesis of alkenes using the Wittig reaction is a traditional part of many undergraduate organic chemistry teaching laboratory curricula. The aqueous medium version of the Wittig reaction presented is a reliable adaptation of this alkene formation reaction as a very safe alternative in the introductory organic chemistry laboratory. The specific aqueous Wittig reactions discussed use a one-pot reagent setup and greener methods that the students can complete within 30 min with partial workup in one laboratory period. The aqueous Wittig reactions presented have been implemented to various aldehydes and take advantage of dilute sodium bicarbonate (“baking soda”) as the only base needed for in the in situ formation of stabilized ylides. Outcomes from the implementation of the proposed aqueous Wittig procedure into the organic chemistry teaching laboratory curriculum are presented. Described also are reaction workup, purification, and analysis of products using 1H NMR and IR spectroscopy.

Published
2016
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