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3. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano-Ravina, Alberto

Published
2023
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7. Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain.

Author

García-Cuesta, Eva M., Martínez, Pablo, Selvaraju, Karthik, Ulltjärn, Gabriel, Gómez Pozo, Adrián Miguel, D'Agostino, Gianluca, Gardeta, Sofia, Quijada-Freire, Adriana, Blanco Gabella, Patricia, Roca, Carlos, del Hoyo, Daniel, Jiménez-Saiz, Rodrigo, García-Rubia, Alfonso, Soler Palacios, Blanca, Lucas, Pilar, Ayala-Bueno, Rosa, Santander Acerete, Noelia, Carrasco, Yolanda, Sorzano, Carlos Oscar, and Martinez, Ana

Published
2024
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8. Occupation, occupational exposures and mammographic density in Spanish women

Author

Jiménez, Tamara, García-Pérez, Javier, van der Haar, Rudolf, Alba, Miguel Ángel, Lucas, Pilar, Sierra, María Ángeles, de Larrea-Baz, Nerea Fernández, Salas-Trejo, Dolores, Llobet, Rafael, Martínez, Inmaculada, Pino, Marina Nieves, Alguacil, Juan, González-Galarzo, Mª Carmen, Martínez-Cortés, Mercedes, Pérez-Gómez, Beatriz, Pollán, Marina, and Lope, Virginia

Published
2021
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10. Características de los pacientes con EPOC tratados en neumología en España según grupos GOLD y fenotipos clínicos GesEPOC

Author

Izquierdo, José Luis, Calle Rubio, Myrian, Lucas, Pilar de, Izquierdo, José Luis, Calle Rubio, Myrian, and Lucas, Pilar de

Abstract

Introducción El objetivo de este estudio ha sido analizar las características clínicas de los pacientes con EPOC vistos en las consultas generales de neumología, el seguimiento de las guías clínicas y la adecuación en la categorización y en el manejo terapéutico. Método Estudio multicéntrico, transversal, cuyo objetivo primario es describir el número, intensidad y variabilidad de los síntomas en los pacientes con EPOC. La recogida de los datos fue realizada en 2015 por 300 neumólogos que evaluaron un total de 3.010 pacientes, de los cuales 2.669 (88,6%) fueron válidos para el análisis. Resultados El 22% eran fumadores activos, destacando un 21 y 17% en los grupos C y D de GOLD y un 17 y 19% en los pacientes exacerbadores de GesEPOC. El 62,3% presentaba comorbilidades asociadas. En el proceso diagnóstico destaca el bajo uso de pruebas como el test de difusión o la medición de volúmenes pulmonares, incluso en los grupos más graves de GOLD o en los fenotipos exacerbadores de GesEPOC. También es minoritario el uso de escalas multidimensionales como BODE (12%) o programas específicos de rehabilitación. El tratamiento se basa en el uso de broncodilatadores y corticoides inhalados, en diferentes combinaciones. El uso de metilxantinas fue minoritario (7%). Conclusiones En consultas de neumología existe una elevada proporción de pacientes EPOC con baja complejidad y un escaso uso de pruebas neumológicas. Se constata un leve cambio en las pautas terapéuticas y la frecuente asociación con comorbilidades que pueden modificar la presentación clínica del paciente., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

11. Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

Author

García-Cuesta, Eva M, primary, Martínez, Pablo, additional, Selvaraju, Karthik, additional, Gómez Pozo, Adrián Miguel, additional, D'Agostino, Gianluca, additional, Gardeta, Sofia, additional, Quijada-Freire, Adriana, additional, Blanco Gabella, Patricia, additional, Roca, Carlos, additional, Jiménez-Saiz, Rodrigo, additional, García-Rubia, Alfonso, additional, Soler Palacios, Blanca, additional, Lucas, Pilar, additional, Ayala-Bueno, Rosa, additional, Santander Acerete, Noelia, additional, carrasco, yolanda, additional, Martinez, Ana, additional, Campillo, Nuria E, additional, Jensen, Lasse D, additional, Rodriguez Frade, Jose Miguel, additional, Santiago, César, additional, and Mellado, Mario, additional

Published
2023
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18. Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

Author

Soler Palacios, Blanca, primary, Villares, Ricardo, additional, Lucas, Pilar, additional, Rodríguez-Frade, José Miguel, additional, Cayuela, Ana, additional, Piccirillo, Jonathan G., additional, Lombardía, Manuel, additional, Delgado Gestoso, David, additional, Fernández-García, Miguel, additional, Risco, Cristina, additional, Barbas, Coral, additional, Corrales, Fernando, additional, Sorzano, Carlos Oscar S., additional, Martínez-Martín, Nuria, additional, Conesa, José Javier, additional, Iborra, Francisco J., additional, and Mellado, Mario, additional

Published
2023
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19. Mammographic density in the environs of multiple industrial sources

Author

Jiménez, Tamara, primary, Pollán, Marina, additional, Domínguez-Castillo, Alejandro, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Castelló, Adela, additional, Fernández de Larrea-Baz, Nerea, additional, Lora-Pablos, David, additional, Salas-Trejo, Dolores, additional, Llobet, Rafael, additional, Martínez, Inmaculada, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Pérez-Gómez, Beatriz, additional, Lope, Virgina, additional, and García-Pérez, Javier, additional

Published
2023
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21. Tobacco Patterns and Risk of Chronic Obstructive Pulmonary Disease: Results From a Cross-Sectional Study

Author

Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, Ruano Raviña, Alberto, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Rey-Brandariz, Julia, Pérez-Ríos, Mónica, Ahluwalia, Jasjit S., Beheshtian, Kiana, Fernández-Villar, Alberto, Represas-Represas, Cristina, Piñeiro, María, Alfageme, Inmaculada, Ancochea, Julio, Soriano, Joan B., Casanova, Ciro, Cosío, Borja G., García-Río, Francisco, Miravitlles, Marc, de Lucas, Pilar, Rodríguez González-Moro, José Miguel, Soler-Cataluña, Juan José, and Ruano Raviña, Alberto

Abstract

Introduction There is still uncertainty about which aspects of cigarette smoking influence the risk of Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to estimate the COPD risk as related to duration of use, intensity of use, lifetime tobacco consumption, age of smoking initiation and years of abstinence. Methods We conducted an analytical cross-sectional study based on data from the EPISCAN-II study (n = 9092). All participants underwent a face-to-face interview and post-bronchodilator spirometry was performed. COPD was defined as post-bronchodilator FEV1/FVC < 70%. Parametric and nonparametric logistic regression models with generalized additive models were used. Results 8819 persons were included; 858 with COPD and 7961 without COPD. The COPD risk increased with smoking duration up to ≥50 years [OR 3.5 (95% CI: 2.3–5.4)], with smoking intensity up to ≥39 cig/day [OR 10.1 (95% CI: 5.3–18.4)] and with lifetime tobacco consumption up to >29 pack-years [OR 3.8 (95% CI: 3.1–4.8)]. The COPD risk for those who started smoking at 22 or later was 0.9 (95% CI: 0.6–1.4). The risk of COPD decreased with increasing years of cessation. In comparison with both never smokers and current smokers, the lowest risk of COPD was found after 15–25 years of abstinence. Conclusion COPD risk increases with duration, intensity, and lifetime tobacco consumption and decreases importantly with years of abstinence. Age at smoking initiation shows no effect. After 15–25 years of cessation, COPD risk could be equal to that of a never smoker. This work suggests that the time it takes to develop COPD in a smoker is about 30 years

Published
2023

22. Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

Author

Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, Iborra, Francisco J. [0000-0002-0692-3696], Soler Palacios, Blanca, Villares, Ricardo, Lucas, Pilar, Rodríguez-Frade, José Miguel, Cayuela, Ana, Piccirillo, Jonathan G., Lombardia, Manuel, Delgado Gestoso, David, Fernández-García, Miguel, Risco Ortiz, Cristina, Barbas, Coral, Corrales, Fernando J., Sorzano, Carlos Óscar S., Martínez-Martín, Nuria, Conesa, José Javier, Iborra, Francisco J., Mellado, Mario, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, Iborra, Francisco J. [0000-0002-0692-3696], Soler Palacios, Blanca, Villares, Ricardo, Lucas, Pilar, Rodríguez-Frade, José Miguel, Cayuela, Ana, Piccirillo, Jonathan G., Lombardia, Manuel, Delgado Gestoso, David, Fernández-García, Miguel, Risco Ortiz, Cristina, Barbas, Coral, Corrales, Fernando J., Sorzano, Carlos Óscar S., Martínez-Martín, Nuria, Conesa, José Javier, Iborra, Francisco J., and Mellado, Mario

Abstract

Introduction: Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage polarization and function and, conversely, phenotypic polarization may drive metabolic reprogramming. Methods: Here we use biochemical analysis, correlative cryogenic fluorescence microscopy and cryo-focused ion-beam scanning electron microscopy. Results: We demonstrate that growth hormone (GH) reprograms inflammatory GM-CSF-primed monocyte-derived macrophages (GM-MØ) by functioning as a metabolic modulator. We found that exogenous treatment of GM-MØ with recombinant human GH reduced glycolysis and lactate production to levels similar to those found in anti-inflammatory M-MØ. Moreover, GH treatment of GM-MØ augmented mitochondrial volume and altered mitochondrial dynamics, including the remodeling of the inner membrane to increase the density of cristae. Conclusions: Our data demonstrate that GH likely serves a modulatory role in the metabolism of inflammatory macrophages and suggest that metabolic reprogramming of macrophages should be considered as a new target to intervene in inflammatory diseases.

Published
2023

23. Protective Cardiovascular Effect of Sleep Apnea Severity in Obesity Hypoventilation Syndrome

Author

García-Ledesma, Estefanía, Sánchez-Quiroga, M-Ángeles, Ordax, Estrella, González-Mangado, Nicolás, Troncoso, Maria F., Martinez-Martinez, Maria-Ángeles, Cantalejo, Olga, Ojeda, Elena, Carrizo, Santiago J., Gallego, Begoña, Pallero, Mercedes, Ramón, Mª Antonia, Díaz-de-Atauri, Josefa, Muñoz-Méndez, Jesús, Senent, Cristina, Sancho-Chust, Jose N., Ribas-Solis, Francisco Javier, Barrot, Emilia, Benítez, José M., Sanchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gomez, Silvia, Bengoa, Mónica, Masa, Juan F., Corral, Jaime, Romero, Auxiliadora, Caballero, Candela, Terán-Santos, Joaquin, Alonso-Álvarez, Maria L., Gomez-Garcia, Teresa, González, Mónica, López-Martín, Soledad, De Lucas, Pilar, Marin, José M., Marti, Sergi, Díaz-Cambriles, Trinidad, Chiner, Eusebi, Merchan, Miguel, Egea, Carlos, Obeso, Ana, and Mokhlesi, Babak

Published
2016
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24. Mid- and Long-term Efficacy of Non-invasive Ventilation in Obesity Hypoventilation Syndrome: The Pickwick's Study

Author

López-Jiménez, María J., Masa, Juan F., Corral, Jaime, Terán, Joaquín, Ordaz, Estrella, Troncoso, Maria F., González-Mangado, Nicolás, González, Mónica, Lopez-Martínez, Soledad, De Lucas, Pilar, Marín, José M., Martí, Sergi, Díaz-Cambriles, Trinidad, Díaz-de-Atauri, Josefa, Chiner, Eusebi, Aizpuru, Felipe, Egea, Carlos, Romero, Auxiliadora, Benítez, José M., Sánchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gómez, Silvia, Barbe, Ferrán, and Bengoa, Mónica

Published
2016
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25. Eficacia a medio y largo plazo de la ventilación no invasiva en el síndrome de hipoventilación-obesidad (estudio Pickwick)

Author

López-Jiménez, María José, Masa, Juan F., Corral, Jaime, Terán, Joaquín, Ordaz, Estrella, Troncoso, Maria F., González-Mangado, Nicolás, González, Mónica, Lopez-Martínez, Soledad, De Lucas, Pilar, Marín, José M., Martí, Sergi, Díaz-Cambriles, Trinidad, Díaz-de-Atauri, Josefa, Chiner, Eusebi, Aizpuru, Felipe, Egea, Carlos, Romero, Auxiliadora, Benítez, José M., Sánchez-Gómez, Jesús, Golpe, Rafael, Santiago-Recuerda, Ana, Gómez, Silvia, Barbe, Ferrán, and Bengoa, Mónica

Published
2016
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26. Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years

Author

Miravitlles, Marc, Soler-Cataluña, Juan José, Soriano, Joan B., García-Rio, Francisco, de Lucas, Pilar, Alfageme, Inmaculada, Casanova, Ciro, Rodríguez González-Moro, José Miguel, Sánchez Herrero, María Guadalupe, Ancochea, Julio, Cosio, Borja G, Universitat Autònoma de Barcelona, [Miravitlles, Marc] Hosp Univ Vall Hebron, Dept Pneumol, Vall dHebron Inst Recerca, Barcelona, Spain, [Miravitlles, Marc] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Soriano, Joan B.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Garcia-Rio, Francisco] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Ancochea, Julio] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Cosio, Borja G.] Inst Salud Carlos III, CIBER Enfermedades Respiratorias, Madrid, Spain, [Jose Soler-Cataluna, Juan] Hosp Arnau Vilanova Lliria, Serv Neumol, Valencia, Spain, [Soriano, Joan B.] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Ancochea, Julio] Hosp Univ Princesa, Serv Neumol, Madrid, Spain, [Soriano, Joan B.] Univ Autonoma Madrid, Madrid, Spain, [Ancochea, Julio] Univ Autonoma Madrid, Madrid, Spain, [Garcia-Rio, Francisco] Hosp Univ Paz IdiPAZ, Serv Neumol, Madrid, Spain, [De Lucas, Pilar] Hosp Gen Gregorio Maranon, Serv Neumol, Madrid, Spain, [Alfageme, Inmaculada] Univ Seville, Hosp Univ Virgen Valme, Unidad Gest Clin Neumol, Seville, Spain, [Casanova, Ciro] Hosp Univ Nuestra Senora Candelaria, Serv Neumol, Tenerife, Spain, [Rodriguez Gonzalez-Moro, Jose Miguel] Univ Alcala, Hosp Univ Principe Asturias Alcala De Henares, Serv Neumol, Madrid, Spain, [Sanchez, Guadalupe] GSK, Dept Med, Madrid, Spain, [Cosio, Borja G.] Hosp Univ Son Espases IdISBa, Serv Neumol, Palma de Mallorca, Spain, Institut Català de la Salut, [Miravitlles M] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. [Soler-Cataluña JJ] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Valencia, Spain. [Soriano JB] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Princesa, and Universidad Autónoma de Madrid, Madrid, Spain. [García-Río F] CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. [de Lucas P] Servicio de Neumología, Hospital General Gregorio Marañon, Madrid, Spain. [Alfageme I] Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Seville, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Pulmonary and Respiratory Medicine, Questionnaire, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Community, Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Physical-activity survey, Scale, Dyspnea, Respiratory Tract Diseases::Lung Diseases [DISEASES], Validation, Adults, Pulmons - Malalties - Epidemiologia, enfermedades respiratorias::enfermedades pulmonares [ENFERMEDADES], Copd, Mortality
Abstract

BackgroundFew large epidemiological studies have analysed the prevalence of respiratory symptoms and their determinants in the general adult population. We investigated the prevalence and determinants of respiratory symptoms and compared their prevalence with that of two previous studies conducted in 1999 and 2009.MethodEPISCAN II was a multicentre, cross-sectional, population-based epidemiological study in individuals older than 40 years.ResultsA total of 9092 individuals were included. Up to 47.5% reported at least one respiratory symptom, being more frequent in women than in men (49.4%versus45.5%, p=0.0002) and with wheezing being the most frequent (33.7%) followed by dyspnoea (26.8%). The presence of any symptom was associated with female sex, higher body mass index (BMI), lower forced expiratory volume in 1 s (FEV1% pred), reduced physical activity, a higher Charlson index and the presence of anxiety and depression. Smoking was also significantly associated with having at least one respiratory symptom in a dose–response fashion (OR: 1.415, 1.916, 2.192 and 2.987 for 0–10, 10–20, 20–30 and >30 pack-years, respectively, all pConclusionsApproximately half of the adult Spanish population have respiratory symptoms and this prevalence has remained quite stable over the last 20 years. Smoking remains the main factor associated with respiratory symptoms, but female sex, comorbidities, high BMI and low FEV1and low physical activity are also significantly associated with respiratory symptoms.

Published
2022

27. Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study

Author

Garcia-Rio, Francisco, primary, Miravitlles, Marc, additional, Soriano, Joan B, additional, Cosío, Borja G, additional, Soler-Cataluña, Juan José, additional, Casanova, Ciro, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez Herrero, María Guadalupe, additional, and Ancochea, Julio, additional

Published
2023
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32. Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation : a population-based study

Author

García-Rio, Francisco, Miravitlles, Marc, Soriano, Joan B, Cosio, Borja G, Soler-Cataluña, Juan José, Casanova, Ciro, de Lucas, Pilar, Alfageme, Inmaculada, Rodríguez González-Moro, José Miguel, Sánchez Herrero, María Guadalupe, Ancochea, Julio, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Garcia-Rio F] Servicio de Neumología, Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Medicina, Madrid, Spain. Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Miravitlles M] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servei de Pneumologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Soriano JB] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Universitario La Princesa, Madrid, Spain. Universidad Autónoma de Madrid, Madrid, Spain. [Cosío BG] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Universitario Son Espases-IdiSBa, Palma de Mallorca, Spain. [Soler-Cataluña JJ] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología, Hospital Arnau de Vilanova-Lliria, Departamento de Medicina, Universitat de València, Valencia, Spain. [Casanova C] Centro de Investigación Biomédica en Red en Enfermedades Respiratorias (CIBERES), Madrid, Spain. Pulmonary Deparment-Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Universidad de La Laguna, Tenerife, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray Computed [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Pulmonary and Respiratory Medicine, Tobacco and the lung, Pulmons - Tomografia, diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::interpretación de imágenes asistida por ordenador::tomografía computarizada por rayos X [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Lung Physiology, técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], personas::fumadores [DENOMINACIONES DE GRUPOS], Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Imaging/CT MRI etc, Inorganic Chemicals::Carbon Compounds, Inorganic::Carbon Monoxide [CHEMICALS AND DRUGS], Fumadors, Monòxid de carboni, Persons::Smokers [NAMED GROUPS], compuestos inorgánicos::compuestos inorgánicos del carbono::monóxido de carbono [COMPUESTOS QUÍMICOS Y DROGAS], Exercise
Abstract

BackgroundPopulation distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.MethodsA sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.ResultsIn never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all pConclusionReduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration numberNCT03028207.

Published
2023

33. Unravelling young COPD and pre-COPD in the general population

Author

Cosío, Borja G., primary, Casanova, Ciro, additional, Soler-Cataluña, Juan José, additional, Soriano, Joan B., additional, García-Río, Francisco, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez, Guadalupe, additional, Ancochea, Julio, additional, and Miravitlles, Marc, additional

Published
2022
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34. Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years

Author

Miravitlles, Marc, primary, Soler-Cataluña, Juan José, additional, Soriano, Joan B., additional, García-Río, Francisco, additional, de Lucas, Pilar, additional, Alfageme, Inmaculada, additional, Casanova, Ciro, additional, Rodríguez González-Moro, José Miguel, additional, Sánchez, Guadalupe, additional, Ancochea, Julio, additional, and Cosío, Borja G., additional

Published
2022
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35. Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming

Author

Palacios, Blanca Soler, primary, Villares, Ricardo, additional, Lucas, Pilar, additional, Miguel-Rodríguez-Frade, José, additional, Cayuela, Ana, additional, Piccirillo, Jonathan G, additional, Lombardía, Manuel, additional, Gestoso, David Delgado, additional, Risco, Cristina, additional, Corrales, Fernando, additional, Sorzano, Carlos Oscar S., additional, Martínez, Nuria, additional, Conesa, José Javier, additional, Iborra, Francisco J., additional, and Mellado, Mario, additional

Published
2022
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37. Sphingomyelin Depletion Inhibits CXCR4 Dynamics and CXCL12-Mediated Directed Cell Migration in Human T Cells

Author

Gardeta, Sofía R., primary, García-Cuesta, Eva M., additional, D’Agostino, Gianluca, additional, Soler Palacios, Blanca, additional, Quijada-Freire, Adriana, additional, Lucas, Pilar, additional, Bernardino de la Serna, Jorge, additional, Gonzalez-Riano, Carolina, additional, Barbas, Coral, additional, Rodríguez-Frade, José Miguel, additional, and Mellado, Mario, additional

Published
2022
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38. Residential proximity to industrial pollution and mammographic density

Author

Jiménez, Tamara, primary, Pollán, Marina, additional, Domínguez-Castillo, Alejandro, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Fernández de Larrea-Baz, Nerea, additional, González-Sánchez, Mario, additional, Salas-Trejo, Dolores, additional, Llobet, Rafael, additional, Martínez, Inmaculada, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Pérez-Gómez, Beatriz, additional, Lope, Virginia, additional, and García-Pérez, Javier, additional

Published
2022
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39. Sociodemographic and Lifestyle Determinants of Adherence to Current Dietary Recommendations and Diet Quality in Middle-Aged Spanish Premenopausal Women

Author

Alonso-Cabezas, Marina, primary, Pollán, Marina, additional, Alonso-Ledesma, Isabel, additional, Fernández de Larrea-Baz, Nerea, additional, Lucas, Pilar, additional, Sierra, Ángeles, additional, Castelló, Adela, additional, Pino, Marina Nieves, additional, Pérez-Gómez, Beatriz, additional, Martínez-Cortés, Mercedes, additional, Lope, Virginia, additional, and Ruiz-Moreno, Emma, additional

Published
2022
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40. Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients

Author

García-Cuesta, Eva M., primary, Rodríguez-Frade, José Miguel, additional, Gardeta, Sofía R., additional, D’Agostino, Gianluca, additional, Martínez, Pablo, additional, Soler Palacios, Blanca, additional, Cascio, Graciela, additional, Wolf, Tobias, additional, Mateos, Nicolas, additional, Ayala-Bueno, Rosa, additional, Santiago, César A., additional, Lucas, Pilar, additional, Llorente, Lucia, additional, Allende, Luis M., additional, González-Granado, Luis Ignacio, additional, Martín-Cófreces, Noa, additional, Roda-Navarro, Pedro, additional, Sallusto, Federica, additional, Sánchez-Madrid, Francisco, additional, García-Parajo, María F., additional, Martínez-Muñoz, Laura, additional, and Mellado, Mario, additional

Published
2022
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44. Residential proximity to industrial pollution and mammographic density

Author

Jiménez, Tamara, Pollán, Marina, Domínguez-Castillo, Alejandro, Lucas, Pilar, Sierra, María Ángeles, Fernández de Larrea-Baz, Nerea, González-Sánchez, Mario, Salas-Trejo, Dolores, Llobet Azpitarte, Rafael, Martinez, Inmaculada, Pino, María Nieves, Martínez-Cortés, Mercedes, Pérez-Gómez, Beatriz, Lope, Virginia, and García-Pérez, Javier

Subjects
Environmental Engineering, Breast Neoplasms, Pollution, Cross-Sectional Studies, Risk Factors, Case-Control Studies, Environmental Chemistry, Humans, Environmental Pollutants, Female, Environmental Pollution, LENGUAJES Y SISTEMAS INFORMATICOS, Waste Management and Disposal, Breast Density
Abstract

[EN] Background: Mammographic density (MD), expressed as percentage of fibroglandular breast tissue, is an important risk factor for breast cancer. Our objective is to investigate the relationship between MD and residential proximity to pol-lutant industries in premenopausal Spanish women. MeOds: A cross-sectional study was carried out in a sample of 1225 women extracted from the DDM-Madrid study. Multiple linear regression models were used to assess the association of MD percentage (and their 95% confidence in-tervals (95%CIs)) and proximity (between 1 km and 3 km) to industries included in the European Pollutant Release and Transfer Register. Results: Although no association was found between MD and distance to all industries as a whole, several industrial sectors showed significant association for some distances: "surface treatment of metals and plastic" (j3 = 4.98, 95%CI = (0.85; 9.12) at, We would like to thank the participants in the DDM-Madrid study for their contribution to breast cancer research. This work was supported by the Carlos III Institute of Health (AESI PI15CIII/0029, AESI PI15CIII/00013, and EPY-505/19-PFIS) . The article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health.

Published
2021

45. Defining the Asthma-COPD Overlap Syndrome in a COPD Cohort

Author

Cosio, Borja G., Soriano, Joan B., López-Campos, Jose Luis, Calle-Rubio, Myriam, Soler-Cataluna, Juan José, de-Torres, Juan P., Marín, Jose M., Martínez-Gonzalez, Cristina, de Lucas, Pilar, Mir, Isabel, Peces-Barba, Germán, Feu-Collado, Nuria, Solanes, Ingrid, Alfageme, Inmaculada, Casanova, Ciro, Calvo Bonachera, José, Lacárcel Bautista, Celia, Domenech, Adolfo, Guzmán, Rosirys, Irigaray, Rosa, Zamora, Meritxell López, Ríos, Angel, Córdova, Rocío, López, Carlos Cabrera, Acosta, Alejandro Sánchez, González, Juan Abreu, Balbin, Ramón Agüero, Balcells, Eva, Campos, Elena Miguel, Marin, Alicia, Casanova, Antonia Llunel, Moreno, Amalia, Márquez Pérez, Francisca Lourdes, Riesco Miranda, Juan Antonio, Rodríguez, Julia Tabara, Gómez, Rafael Golpe, de Miguel Díez, Javier, Río, Francisco García, Lobato, Salvador Díaz, Galdiz Iturri, Juan Bautista, Royo, Margarita Marín, and de Diego Damia, Alfredo

Published
2016
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46. Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

Author

Toribio, María José, primary, Priego-Capote, Feliciano, additional, Pérez-Gómez, Beatriz, additional, Fernández de Larrea-Baz, Nerea, additional, Ruiz-Moreno, Emma, additional, Castelló, Adela, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Luque de Castro, María Dolores, additional, Lope, Virginia, additional, and Pollán, Marina, additional

Published
2021
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47. The burden of COPD in young individuals: results from EPISCAN II

Author

García Cosío Piqueras, Borja, primary, Casanova, Ciro, additional, Soriano, Joan B, additional, Alfageme, Inmaculada, additional, Miravitlles, Marc, additional, De Lucas, Pilar, additional, Soler-Cataluña, Juan Jose, additional, García-Río, Francisco, additional, Rodriguez Gonzalez-Moro, Jose Miguel, additional, Sanchez-Herrero, Guadalupe, additional, and Ancochea, Julio, additional

Published
2021
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