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Getting from A to B has never been easier. Mobile navigation systems allow universal access to spatial information. However, following detailed route instructions leads to a decrease in spatial exploration behaviour and, therefore a reduction of spatial knowledge acquisition. Facilitating spatial exploration has the potential to counteract this negative efect. This paper investigates how we can support people in re-discovering their surroundings. We designed and evaluated a mobile application to promote spatial exploration through gamification. The app requires active exploration behaviour to uncover a map. Gamification elements such as quests, statistics, and social competition are used to encourage exploration. We conducted an exploratory field study (n = 22). Our results show a significant increase in familiarity with the environment and various exploration patterns. Based on our findings, we propose modifications to current mapping applications by limiting the visible cartographic elements and alternating routes to improve spatial knowledge acquisition.

Differentiating between benign and malignant biliary stenosis (BS) is challenging, where tissue diagnosis plays a crucial role. Endoscopic retrograde cholangiopancreatography (ERCP)-based tissue sampling and endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) or biopsy (FNB) are used to obtain tissue specimens from BS. The aim of this retrospective study was to evaluate the diagnostic yield of EUS-FNA/B plus ERCP with brushing or forceps biopsy in BS. All endoscopic procedures performed in patients with BS at our gastroenterology unit were reviewed. The gold standard for diagnosis was histopathology of surgical specimens or the progression of the malignancy at radiological or clinical follow-up. A total of 70 endoscopic procedures were performed in 51 patients with BS. Final endoscopic diagnosis was reached in 96% of the patients and was malignant in 61.7% and benign in 38.3% of cases. Sensitivity, specificity, and diagnostic accuracy were 73.9%, 100%, and 80%, respectively, for EUS-FNA/B; 66.7%, 100%, and 82.5% for ERCP; and 83.3%, 100%, and 87.5% for both procedures carried out in the same session. The combination of EUS and ERCP tissue sampling seems to increase diagnostic accuracy in defining the etiology of BS. Performing both procedures in a single session reduces the time required for diagnostic work-up and optimizes resources.

Patient: Male, 42-year-old Final Diagnosis: Neuroendocrine tumor Symptoms: Abdominal pain Medication:— Clinical Procedure: — Specialty: Surgery Objective: Unusual clinical course Background: Jejunoileal neuroendocrine tumors (JI-NETs) are rare tumors that can be associated with mesenteric fibrosis. This case report is of an incidental finding of a JI-NET in a patient who was previously misdiagnosed with sclerosing mesenteritis. Case Report: A 42-year-old man was admitted to our institution with diffuse abdominal pain and clinical and radiographic signs of bowel obstruction. He had a previous diagnosis of sclerosing mesenteritis, which had been histologically diagnosed after an exploratory laparoscopy performed in 2009 for recurrent acute abdominal pain. He was also annually monitored through computed tomography scans for an incidentally discovered, gradually enlarging mesenteric mass for which a “wait and watch” management approach was adopted. After a period of fasting and observation, the patient underwent an urgent exploratory laparotomy because of his worsening condition. Intraoperatively, an ileocecal resection was performed, along with excision of the known mesenteric mass. The pathology report revealed an ileal NET with nodal metastases within the mesentery and mesenteric tumor deposits (pT3N1). Conclusions: JI-NETs are rare entities, which are usually encountered as incidental findings or in patients with unspecific abdominal pain. Our case represents a probable delayed diagnosis of JI-NET in the context of sclerosing mesenteritis; therefore, a possible association between these 2 conditions should be investigated.

In this workshop, we will explore and discuss future developments in mobile user-interfaces for cyclists and users of similar interfaces or services. We highlight the challenge of balancing safety and ecological validity in experiments, and how novel and improved evaluation methods can improve the current situation. We aim to bring together researchers with a strong background in designing and evaluating novel user interfaces in the domain of bicycles and mobility, as well as practitioners who build consumer products in that domain. The workshop’s goal is to explore novel ways of designing and evaluating user interfaces for cyclists and similar users when it comes to interacting with mobile devices and services on the ride.

Simple Summary This article expresses the viewpoint of the authors’ management of low rectal cancer in ulcerative colitis (UC). This subject suffers from a paucity of literature and therefore management decision is very difficult to take. The aim of this paper is to provide a structured approach to a challenging situation. It is subdivided into two parts: a first part where the existing literature is reviewed critically, and a second part in which, on the basis of the literature review and their extensive clinical experience, a management algorithm is proposed by the authors to offer guidance to surgical and oncological practices. This text adds to the literature a useful guide for the treatment of these complex clinical scenarios. Abstract Low rectal Carcinoma arising at the background of Ulcerative Colitis poses significant management challenges to the clinicians. The complex decision-making requires discussion at the multidisciplinary team meeting. The published literature is scarce, and there are significant variations in the management of such patients. We reviewed treatment protocols and operative strategies; with the aim of providing a practical framework for the management of low rectal cancer complicating UC. A practical treatment algorithm is proposed.

Many researchers have been concerned with whether social media has a negative impact on the well-being of their audience. With the popularity of social networking sites (SNS) steadily increasing, psychological and social sciences have shown great interest in their effects and consequences on humans. In this work, we investigate Facebook using the tools of HCI to find connections between interface features and the concerns raised by these domains. Using an empirical design analysis, we identify interface interferences impacting users’ online privacy. Through a subsequent survey (n = 116), we find usage behaviour changes due to increased privacy concerns and report individual cases of addiction and mental health issues. These observations are the results of a rapidly changing SNS creating a gap of understanding between users’ interactions with the platform and future consequences. We explore how HCI can help close this gap and work towards more ethical user interfaces in the future.

Cycling is on the rise as a relevant alternative to car-based mobility and even though there are mobile applications specifically designed for cyclists to support this development, many still face unresolved challenges in terms of safe user interaction with complex data while riding. We present the design, development, and evaluation of VeloCity - an application for reporting traffic incidents and structures relevant to cyclists. In a case study, we compared its’ three input methods (touch, in-app speech recognition, the voice assistant of the operating system) to evaluate which attributes make for safe interaction while cycling. We found that participants prefer to use the voice assistant over the other modalities as it was the least distracting due to its hands- and eyes-free interaction design. Furthermore, they chose short commands over conversational phrases. Based on our results, we present five guidelines for designing voice user interfaces for cyclists and argue for moving away from touch-based interfaces in this domain, which still make up most of the applied interaction techniques today.

International audience; The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-kappaB transcription factor pathway associates with advanced disease stages and shorter survival in patients with CRC. NF-kappaB has been shown to drive tumor-promoting inflammation, cancer cell survival, and intestinal epithelial cell (IEC) dedifferentiation in mouse models of CRC. However, whether NF-kappaB affects the metabolic adaptations that fuel aggressive disease in patients with CRC is unknown. Here, we identified carboxylesterase 1 (CES1) as an essential NF-kappaB-regulated lipase linking obesity-associated inflammation with fat metabolism and adaptation to energy stress in aggressive CRC. CES1 promoted CRC cell survival via cell-autonomous mechanisms that fuel fatty acid oxidation (FAO) and prevent the toxic build-up of triacylglycerols. We found that elevated CES1 expression correlated with worse outcomes in overweight patients with CRC. Accordingly, NF-kappaB drove CES1 expression in CRC consensus molecular subtype 4 (CMS4), which is associated with obesity, stemness, and inflammation. CES1 was also upregulated by gene amplifications of its transcriptional regulator HNF4A in CMS2 tumors, reinforcing its clinical relevance as a driver of CRC. This subtype-based distribution and unfavorable prognostic correlation distinguished CES1 from other intracellular triacylglycerol lipases and suggest CES1 could provide a route to treat aggressive CRC.

Visual as-the-crow-flies (ATCF) navigation methods are an increasingly popular alternative to existing turn-by-turn (TBT) navigation for cyclists. To better understand how people use them in everyday navigation and how they cope with the novel navigation method in challenging situations, we studied two main issues posed by ATCF navigation: knowing whether one is on the right route to their destination and knowing whether a turn leads into a dead end or detour. To investigate these two problems, we compared visual ATCF navigation against (1) TBT navigation and (2) an improved ATCF+ navigation system in two successive studies. We found that users encountered problems riding in the opposite direction to the destination and were often turning around as a result using the ATCF method. Using colour cues in the ATCF user interface we were able to reinforce correct route choices. Additionally, we found that unsuccessful route progression negatively correlates with user confidence.

Mobile navigation apps are among the most used mobile applications and are often used as a baseline to evaluate new mobile navigation technologies in field studies. As field studies often introduce external factors that are hard to control for, we investigate how pedestrian navigation methods can be evaluated in virtual reality (VR). We present a study comparing navigation methods in real life (RL) and VR to evaluate if VR environments are a viable alternative to RL environments when it comes to testing these. In a series of studies, participants navigated a real and a virtual environment using a paper map and a navigation app on a smartphone. We measured the differences in navigation performance, task load and spatial knowledge acquisition between RL and VR. From these we formulate guidelines for the improvement of pedestrian navigation systems in VR like improved legibility for small screen devices. We furthermore discuss appropriate low-cost and low-space VR-locomotion techniques and discuss more controllable locomotion techniques.

As in many other research areas the material sciences produce vast amounts of experimental data. The corresponding findings are then published, albeit the data remains in heterogeneous formats within institutes and is neither shared nor reused by the scientific community. To address this issue we have developed and deployed a scientific data management environment for the material sciences at various test facilities. Unlike other systems this one explicitly models every facet of the experiment and the materials used therein - thereby supporting the initial design of the experiment, its execution and the ensuing results. Consequently, the collection of the structured data becomes an integral part of the research workflow rather than a post hoc nuisance. In this paper we report on an empirical study that was performed to test the effects of a paradigm change in the data model to align it better with the actual scientific practice at hand.

// Gabriella Mincione 1, 2 , Maria Carmela Di Marcantonio 1 , Chiara Tarantelli 1, 6 , Luca Savino 1 , Donatella Ponti 3 , Marco Marchisio 2, 4 , Paola Lanuti 2, 4 , Silvia Sancilio 5 , Antonella Calogero 3 , Roberta Di Pietro 4 , Raffaella Muraro 1, 2 1 Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, Italy 2 Center for Aging Science and Translational Medicine (CeSI-MeT), Chieti, Italy 3 Department of Medico-Surgical Sciences and Biotechnologies, University of Rome Sapienza, Latina, Italy 4 Department of Medicine and Ageing Sciences, University “G. d’Annunzio”, Chieti-Pescara, Italy 5 Department of Pharmacy, University “G. d’Annunzio”, Chieti-Pescara, Italy 6 Current Address: Lymphoma and Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland Correspondence to: Gabriella Mincione, email: gabriella.mincione@unich.it Keywords: EGFR, ZNF216, nuclear EGFR Received: July 07, 2016 Accepted: September 25, 2016 Published: October 06, 2016 ABSTRACT Epidermal Growth Factor Receptor (EGFR), a member of the ErbB family of receptor tyrosine kinase (RTK) proteins, is aberrantly expressed or deregulated in tumors and plays pivotal roles in cancer onset and metastatic progression. ZNF216 gene has been identified as one of Immediate Early Genes (IEGs) induced by RTKs. Overexpression of ZNF216 protein sensitizes 293 cell line to TNF-α induced apoptosis. However, ZNF216 overexpression has been reported in medulloblastomas and metastatic nasopharyngeal carcinomas. Thus, the role of this protein is still not clearly understood. In this study, the inverse correlation between EGFR and ZNF216 expression was confirmed in various human cancer cell lines differently expressing EGFR. EGF treatment of NIH3T3 cells overexpressing both EGFR and ZNF216 (NIH3T3-EGFR/ZNF216), induced a long lasting activation of EGFR in the cytosolic fraction and an accumulation of phosphorylated EGFR (pEGFR) more in the nuclear than in the cytosolic fraction compared to NIH3T3-EGFR cells. Moreover, EGF was able to stimulate an increased expression of ZNF216 in the cytosolic compartment and its nuclear translocation in a time-dependent manner in NIH3T3-EGFR/ZNF216. A similar trend was observed in A431 cells endogenously expressing the EGFR and transfected with Znf216 . The increased levels of pEGFR and ZNF216 in the nuclear fraction of NIH3T3-EGFR/ZNF216 cells were paralleled by increased levels of phospho-MAPK and phospho-Akt. Surprisingly, EGF treatment of NIH3T3-EGFR/ZNF216 cells induced a significant increase of apoptosis thus indicating that ZNF216 could sensitize cells to EGF-induced apoptosis and suggesting that it may be involved in the regulation and effects of EGFR signaling.

A case of spontaneous, but not contemporary rupture of both kidneys in a 42-year-old man with tuberous sclerosis is described. Despite the high incidence of renal involvement, chronic renal failure due to replacement and compression of renal tissue by hamartomas is rare. We reviewed 25 cases in the literature and found only 1 other case which necessitated maintenance hemodialytic treatment for kidney rupture. It is suggested that early diagnosis and conservative partial nephrectomy could prevent or delay the onset of chronic renal failure, malignant transformation and dramatic rupture of hamartomas.