Author: "Luca Sacchelli" - Searchworks@Jio Institute Digital Library Search Results

12 results on '"Luca Sacchelli"'

1. Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

Author: Camilla Tiezzi, Andrea Vecchi, Marzia Rossi, Davide Cavazzini, Angelo Bolchi, Diletta Laccabue, Sara Doselli, Amalia Penna, Luca Sacchelli, Federica Brillo, Tiziana Meschi, Andrea Ticinesi, Antonio Nouvenne, Gaetano Donofrio, Paola Zanelli, Magda Benecchi, Silvia Giuliodori, Paola Fisicaro, Ilaria Montali, Camilla Ceccatelli Berti, Valentina Reverberi, Anna Montali, Simona Urbani, Giuseppe Pedrazzi, Gabriele Missale, Amalio Telenti, Davide Corti, Simone Ottonello, Carlo Ferrari, and Carolina Boni
Subjects: Immunology, Virology, Sequence analysis, Sequence homology, Science
Abstract: Summary: Humoral immunity is sensitive to evasion by SARS-CoV-2 mutants, but CD8 T cells seem to be more resistant to mutational inactivation. By a systematic analysis of 30 spike variant peptides containing the most relevant VOC and VOI mutations that have accumulated overtime, we show that in vaccinated and convalescent subjects, mutated epitopes can have not only a neutral or inhibitory effect on CD8 T cell recognition but can also enhance or generate de novo CD8 T cell responses. The emergence of these mutated T cell function enhancing epitopes likely reflects an epiphenomenon of SARS-CoV-2 evolution driven by antibody evasion and increased virus transmissibility. In a subset of individuals with weak and narrowly focused CD8 T cell responses selection of these heteroclitic-like epitopes may bear clinical relevance by improving antiviral protection. The functional enhancing effect of these peptides is also worth of consideration for the future development of new generation, more potent COVID-19 vaccines.
Published: 2023
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2. Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

Author: Camilla Tiezzi, Andrea Vecchi, Marzia Rossi, Davide Cavazzini, Angelo Bolchi, Diletta Laccabue, Luca Sacchelli, Federica Brillo, Tiziana Meschi, Andrea Ticinesi, Antonio Nouvenne, Gaetano Donofrio, Paola Zanelli, Magda Benecchi, Silvia Giuliodori, Paola Fisicaro, Ilaria Montali, Simona Urbani, Giuseppe Pedrazzi, Gabriele Missale, Amalio Telenti, Davide Corti, Simone Ottonello, Carlo Ferrari, and Carolina Boni
Abstract: Mutations carried by SARS-CoV-2 spike protein variants may promote viral escape from immune protection. Humoral immunity is sensitive to evasion by SARS-CoV-2 mutants, but the impact of viral evolution on the interplay between virus and host CD8 T cell reactivity remains uncertain. By a systematic functional analysis of 30 spike variant mutations, we show that in vaccinated as well as convalescent subjects, mutated epitopes can have not only a neutral or abrogating effect on the recognition by CD8 T cells but can also enhance or even generate de novo CD8 T cell responses. Large pools of peptides spanning the entire spike sequence and comprising previously identified CD8 T cell epitopes were then used in parallel with variant peptides to define strength and multispecificity of total anti-spike CD8 responses. In some individuals, CD8 cells were narrowly focused on a few epitopes indicating that in this context of weak and oligospecific responses the overall antiviral protection can likely benefit of the function enhancing effect of heteroclitic-like mutations. In conclusion, appearance of mutated stimulatory epitopes likely reflects an epiphenomenon of SARS-CoV-2 evolution driven by antibody evasion and increased transmissibility, that might bear clinical relevance in a subset of individuals with weak and oligospecific CD8 T cell responses.
Published: 2022

3. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

Author: Alessandra Orlandini, Gabriele Missale, Cristina Mori, Alessandro Zerbini, Carlo Ferrari, Luca Sacchelli, Paola Fisicaro, Carolina Boni, Caterina Valdatta, and Marco Massari
Subjects: Adult, CD4-Positive T-Lymphocytes, Male, Interleukin 2, Hepatitis B virus, HBsAg, CD8-Positive T-Lymphocytes, Biology, medicine.disease_cause, Interferon-gamma, Hepatitis B, Chronic, Immune system, medicine, Humans, Immunity, Cellular, Hepatitis B Surface Antigens, Innate immune system, ELISPOT, Gastroenterology, virus diseases, Middle Aged, Acquired immune system, NKG2D, Virology, CD56 Antigen, digestive system diseases, Killer Cells, Natural, Phenotype, Immunology, medicine.drug
Abstract: Background and Aim: Innate immunity appears to be silent in acutely heptitis B virus (HBV)-infected chimpanzees, as shown by microarray analysis of intrahepatic gene expression. Whether this observation also applies to HBV pathogenesis in man remains undefined. The aim of this study was thus to characterise natural killer (NK) and CD56 + natural T (NT) cell responses early after human HBV infection and their relationship to the induction of adaptive immunity. Methods: Two HBV-seronegative blood donors who became hepatitis B surface antigen (HBsAg) and HBV DNA positive but had persistently normal alanine aminotransferase (ALT) were followed from a very early stage of HBV infection. The phenotype (CD69 and NKG2D) and function (cytotoxicity and interferon γ (IFNγ) production) of NK and NT cells were analysed. CD4- and CD8-mediated responses were studied in parallel with overlapping peptides covering the entire HBV sequence by ex vivo intracellular cytokine staining (ICS) for IFNγ, interleukin 2 (IL2), IL4 and IL10, and by ex vivo Elispot for IFNγ. Healthy subjects, and patients with chronic and acute HBV infection were studied for comparison. Results: An early induction of both innate and adaptive responses was observed. NK and NT cells showed faster kinetics than HBV-specific T cells with an earlier peak of activity, while CD4 + and CD8 + cell responses were mounted with a similar profile, with higher frequencies of IFNγ-producing CD8 + cells at the peak of the response. Conclusions: The innate immune system is able to sense HBV infection, as shown by the early development of NK and NT cell responses, which probably contribute to contain the HBV infection and to allow timely induction of adaptive responses.
Published: 2009

4. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

Author: Gabriele Missale, Luca Sacchelli, Maria Cristina Cavallo, Giuseppe Pedrazzi, Alessandra Orlandini, D. Tola, Simona Urbani, Barbara Amadei, and Carlo Ferrari
Subjects: Time Factors, T-Lymphocytes, medicine.medical_treatment, T cell, Programmed Cell Death 1 Receptor, Viremia, Hepacivirus, Biology, Antiviral Agents, B7-H1 Antigen, Interferon-gamma, Antigen, Antigens, CD, medicine, Humans, Cytotoxic T cell, Interferon gamma, Interferon alfa, Cell Proliferation, Hepatology, Dendritic Cells, Hepatitis C Antibodies, Hepatitis C, Chronic, Flow Cytometry, medicine.disease, Blockade, Treatment Outcome, Cytokine, medicine.anatomical_structure, Immunology, RNA, Viral, Apoptosis Regulatory Proteins, Follow-Up Studies, medicine.drug
Abstract: Background/Aims HCV-specific T cells in acute hepatitis C with subsequent chronic evolution are dysfunctional and most of them express PD-1. The aim of the study was to investigate to what extent the antiviral T cell function can be restored by reversing T cell exhaustion by PD-1/PD-L1 blockade and to assess whether this restoration is favored by IFN-α treatment. Methods PD-1 and PD-L1 expression was studied on T cells and dendritic cells, respectively, of 14 patients with acute hepatitis C and different evolutions of infection. The effect of anti-PD-L1 was analyzed on proliferation, cytokine production and cytolytic activity of CD4 and CD8 T cells. Results While PD-1 expression dropped concurrently with spontaneous or IFN-α induced HCV–RNA decline, PD-L1 levels on dendritic cells increased during IFN-α treatment. Anti-PD-L1 antibodies improved expansion and cytokine production but not the cytolytic activity of HCV-specific T cells. This restoration tended to be greater at lower levels of viremia and PD-1 expression and during PEG-IFNα treatment. Conclusions PD-1/PD-L1 blockade has an immunoregulatory activity which may synergize with the antiviral effect of IFN-α therapy and should be thus explored further in long-lasting chronic HCV infections in the perspective of improving the efficacy of available antiviral treatments.
Published: 2008

5. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses

Author: D. Tola, Luca Sacchelli, Gabriele Missale, Cristina Mori, Paola Fisicaro, Simona Urbani, Alessandra Orlandini, Barbara Amadei, and Carlo Ferrari
Subjects: CD4-Positive T-Lymphocytes, T cell, Hepacivirus, CD8-Positive T-Lymphocytes, In Vitro Techniques, Biology, Virus, medicine, Humans, Cytotoxic T cell, Interferon gamma, Interleukin-7 receptor, Immunity, Cellular, Hepatology, ELISPOT, Interleukin, Hepatitis C, Virology, medicine.anatomical_structure, Acute Disease, CD4 Antigens, Immunology, RNA, Viral, Hepatitis C Antigens, Immunologic Memory, CD8, medicine.drug
Abstract: A timely, efficient, and coordinated activation of both CD4 and CD8 T cell subsets following HCV infection is believed to be essential for HCV control. However, to what extent a failure of the individual T cell subsets can contribute to the high propensity of HCV to persist is still largely undefined. To address this issue, we analyzed the breadth, vigor, and quality of CD4 and CD8 responses simultaneously with panels of peptides covering the entire HCV sequence or containing the HLA-A2-binding motif, and with recombinant HCV proteins in 16 patients with acute HCV infection by tetramer staining, ELISPOT, and intracellular cytokine staining for interferon gamma, interleukin (IL)-2, IL-4, and IL-10. Our results indicate that at clinical onset, CD8 responses are similarly weak and narrowly focused in both self-limited and chronically evolving infections. At this stage, CD4 responses are deeply impaired in patients with a chronic outcome as they are weak and of narrow specificity, unlike the strong, broad and T helper 1-oriented CD4 responses associated with resolving infections. Only patients able to finally control infection show maturation of CD8 memory sustained by progressive expansion of CD127+ CD8 cells. Thus, a poor CD8 response in the acute stage of infection may enhance the overall probability of chronic viral persistence. In conclusion, the presence of functional CD4 responses represents one of the factors dictating the fate of infection by directly contributing to control of the virus and by promoting maturation of protective memory CD8 responses.
Published: 2006

6. Limited Sampling Strategy for the Estimation of Systemic Exposure to the Protease Inhibitor Nelfinavir

Author: Mario Regazzi, Francesca Gatti, Paula Castelli, Renato Maserati, Paola Villani, Palma Delle Foglie, Lucia Testa, Carmine Tinelli, Maria Cusato, Luca Sacchelli, Elena Briganti, Rinaldo Roda, Annalisa De Silvestri, Giulia Nardini, Fernanda Mori, and Patrizia Zucchi
Subjects: medicine.medical_specialty, Cirrhosis, HIV Infections, Pharmacology, Gastroenterology, Pharmacokinetics, Internal medicine, Humans, Medicine, Pharmacology (medical), Blood Specimen Collection, Nelfinavir, medicine.diagnostic_test, business.industry, Area under the curve, HIV Protease Inhibitors, Venous blood, medicine.disease, Therapeutic drug monitoring, Area Under Curve, Coinfection, Drug Monitoring, business, Blood sampling, medicine.drug
Abstract: Therapeutic drug monitoring (TDM) of antiretroviral drugs has been proposed as a means of optimizing response to highly active antiretroviral therapy (HAART) in HIV infection because sub-optimal exposure to these agents may lead to the development of resistant viral strains and subsequent therapeutic failure. The area under the curve (AUC), though considered to make the best estimate of total drug exposure, requires repeated blood sampling. The authors investigated the predictability of individual nelfinavir (NFV) concentrations at different time points for the AUC and tried to find the best sampling time for the abbreviated AUC to predict NFV total body exposure. A total of 99 NFV AUC 0 - 1 2 h values were measured in 99 patients receiving a 1250-mg oral dose twice a day. Venous blood samples were collected at baseline (predose, 0) and 1, 2, 3, 4, 5, 6, 8, and 12 hours postdose. A stepwise forward-selection, multiple-regression technique was chosen to assess the relative importance of single and combination concentration time points to predict the AUC calculated from the entire pharmacokinetic profile. Data were split into a development set and a validation set. The development set contained 49 randomly selected HIV + patients. Of these, 22 HIV + patients were coinfected with HCV, 7 with and 15 without cirrhosis. One-point predictors provided the lowest prediction precision, but predictive performance improved after the first 2 hours postdose. Plasma concentrations at 0 and 4 hours after the oral dose were most predictive if 2 variables were used in the regression equation. The AUC could be estimated from data for these 2 samples by using the following equation: AUC 0 - 1 2 = 3.0 + 2.7 (C 0 ) + 6.4 (C 4 ), r 2 = 92. The predictive performance of 2-point predictors at 0 and 4 hours (C 0 + C 4 ) was validated by comparing their ability to predict the full AUC in a validation set representative of HIV + /HCV - patients (n = 28) and HIV + /HCV + patients, with (n = 8) and without (n = 14) cirrhosis. The results showed a mean bias ranging from +2.7% in HIV + /HCV - patients to -6.0% in HCV coinfection with cirrhosis. The authors conclude that this result is clinically significant. The limited sampling strategy (LSS) described could be used in clinical practice for the easy assessment of the total exposure to NFV in HIV + /HCV + patients, both with and without cirrhosis.
Published: 2005

7. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B

Author: Carlo Ferrari, Caterina Valdatta, Marco Massari, Luca Sacchelli, Paola Fisicaro, Enrico Maria Silini, Pietro Andreone, Elisabetta Biasini, Elisabetta Loggi, Gabriele Missale, Maria Cristina Cavallo, Fisicaro P, Valdatta C, Massari M, Loggi E, Biasini E, Sacchelli L, Cavallo MC, Silini EM, Andreone P, Missale G, and Ferrari C.
Subjects: Adult, Male, Interleukin 2, Hepatitis B virus, Biopsy, T cell, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, Biology, medicine.disease_cause, Antibodies, Interleukin-7 Receptor alpha Subunit, Interferon-gamma, Hepatitis B, Chronic, Antigen, Antigens, CD, Interferon, medicine, Humans, Antigens, Viral, Aged, Cell Proliferation, Hepatology, Gastroenterology, Middle Aged, Hepatitis B, medicine.disease, medicine.anatomical_structure, Liver, CTLA-4, Immunology, Interleukin-2, Female, Apoptosis Regulatory Proteins, CD8, Signal Transduction, medicine.drug
Abstract: BACKGROUND & AIMS: The antiviral function of peripheral hepatitis B virus (HBV)-specific T cells can be increased in patients with chronic hepatitis B by blocking the interaction of programmed death (PD)-1 with its ligand PD-L1. However, no information is available about the effects of this blockade on intrahepatic lymphocytes. We studied T-cell exhaustion and the effects of PD-1/PD-L1 blockade on intrahepatic and circulating HBV-specific T cells in patients with chronic hepatitis B. METHODS: A total of 42 patients with chronic HBV infection who underwent liver biopsy were studied. The ex vivo phenotype of peripheral and intrahepatic HBV-specific CD8(+) T cells was assessed by flow cytometry with class I tetramers and antibodies to T-cell differentiation molecules. Functional recovery was evaluated by analyzing expansion and production of interferon (IFN)-gamma and interleukin (IL)-2 after short-term incubation of T cells with HBV peptides in the presence of anti-PD-L1 or control antibodies. RESULTS: Intrahepatic HBV-specific CD8(+) cells expressed higher levels of PD-1 and lower levels of CD127 than their peripheral counterparts. Blockade of PD-1/PD-L1 interaction increased CD8(+) cell proliferation and IFN-gamma and IL-2 production by circulating intrahepatic lymphocytes, even though anti-PD-L1 had a stronger effect on intrahepatic compared with peripheral T cells. CONCLUSIONS: T-cell exhaustion by high antigen concentrations promotes HBV-specific T-cell dysfunction by affecting phenotype and function of peripheral and intrahepatic T cells. By restoring antiviral T-cell functions, not only in peripheral but also in intrahepatic lymphocytes, anti-PD-L1 might be a good therapeutic candidate for chronic HBV infection.
Published: 2010

8. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

Author: Gabriele Missale, Amalia Penna, Sergio Mezzadri, Alessandro Zerbini, Luca Sacchelli, Carlo Ferrari, Alessandra Orlandini, and Massimo Pilli
Subjects: Adult, Male, Pore Forming Cytotoxic Proteins, T cell, CD8 Antigens, Programmed Cell Death 1 Receptor, Hepacivirus, CD8-Positive T-Lymphocytes, Epitope, Granzymes, Interleukin-7 Receptor alpha Subunit, Interferon-gamma, Antigen, Antigens, CD, medicine, Humans, Cells, Cultured, Aged, Membrane Glycoproteins, Hepatology, biology, Perforin, Tumor Necrosis Factor-alpha, Degranulation, virus diseases, Antibodies, Monoclonal, Hepatitis C, Chronic, Middle Aged, Virology, digestive system diseases, medicine.anatomical_structure, Immunology, biology.protein, Female, Antibody, Apoptosis Regulatory Proteins, CD8, Ex vivo
Abstract: The functional impairment of HCV-specific T cell responses is believed to be an important determinant of HCV persistence, but the functional T cell defects of patients with chronic hepatitis C (CH-C) are only partially defined. CD8 responses to HLA-A2–restricted epitopes of HCV and other unrelated viruses were studied in 23 HLA-A2–positive patients both ex vivo and after in vitro culture. Degranulation capacity, intracellular perforin, and granzyme-A content and cytokine production (IFN-γ, TNF-α) by HCV- and non–HCV-specific CD8 cells were tested both ex vivo and in vitro, whereas cytolytic activity was studied after 10 days' expansion in vitro. Memory maturation and role of exhaustion were assessed ex vivo by HCV-specific CD8 staining for CD127 and PD-1, and in vitro after peripheral blood mononuclear cells (PBMC) culture in the presence of anti–PD-L1 monoclonal antibodies. IFN-γ production and cytolytic activity were expressed less efficiently by HCV-specific than by non–HCV specific CD8 cells derived from the same CH-C patients. The amount of stored granzyme-A within single cells was always lower in HCV-specific CD8 cells, which were less efficient also in the release of lytic granules and in the production of TNF-α. The CD8 dysfunction was associated with high PD-1 expression by most HCV-specific CD8 cells, and PD-1/PD-L1 blockade by anti–PD-L1 antibodies in vitro was able to improve the HCV-specific CD8 function. Conclusion: Our study characterizes CD8 defects that may be important in maintaining HCV persistence; identification of strategies to correct these defects may help to define novel approaches to treat HCV infection. (HEPATOLOGY 2007;45:588–601.)
Published: 2007

9. Clinical pharmacokinetics of nelfinavir and its metabolite M8 in human immunodeficiency virus (HIV)-positive and HIV-hepatitis C virus-coinfected subjects

Author: Patrizia Zucchi, Palma Delle Foglie, Paula Castelli, Lucia Testa, Francesca Gatti, Maria Cusato, Paola Villani, Giulia Nardini, Rinaldo Roda, Luca Sacchelli, Fernanda Mori, Elena Briganti, Mario Regazzi, Paolo Fabris, and Renato Maserati
Subjects: Adult, Liver Cirrhosis, Male, Quality Control, medicine.medical_specialty, Cirrhosis, Adolescent, Hepacivirus, Hepatitis C virus, HIV Infections, medicine.disease_cause, Gastroenterology, Antiviral Agents, Liver disease, Acquired immunodeficiency syndrome (AIDS), Internal medicine, Antiretroviral Therapy, Highly Active, HIV Seropositivity, medicine, Humans, Pharmacology (medical), Biotransformation, Chromatography, High Pressure Liquid, Pharmacology, Nelfinavir, biology, medicine.diagnostic_test, virus diseases, HIV Protease Inhibitors, Middle Aged, biology.organism_classification, medicine.disease, Hepatitis C, Infectious Diseases, Therapeutic drug monitoring, Area Under Curve, Immunology, Lentivirus, Female, Spectrophotometry, Ultraviolet, Drug Monitoring, medicine.drug
Abstract: In order to evaluate the potential risk of nelfinavir (NFV) accumulation in human immunodeficiency virus (HIV)-hepatitis C virus (HCV)-coinfected patients with liver disease, we investigated the concentrations of NFV and M8, the active metabolite of NFV, in plasma HIV-positive (HIV+) patients coinfected with HCV. A total of 119 HIV+ subjects were included in our study: 67 HIV+ patients, 32 HIV+ and HCV-positive (HCV+) patients without cirrhosis, and 20 HIV+ and HCV+ patients with cirrhosis. Most of the enrolled patients (chronically treated) were taking NFV at the standard dosage of 1,250 mg twice a day. To assay plasma NFV and M8 concentrations, patients underwent serial plasma samplings during the dosing interval at steady state. Plasma NFV and M8 concentrations were measured simultaneously by a high-performance liquid chromatography method with UV detection. The HIV+ and HCV+ patients with and without cirrhosis had significantly lower NFV oral clearances than the HIV+ and HCV-negative individuals (28 and 58% lower, respectively; P < 0.05), which translated into higher areas under the concentration-time curves for cirrhotic and noncirrhotic patients. The NFV absorption rate was significantly lower in cirrhotic patients, resulting in a longer time to the maximum concentration in serum. The mean ratios of the M8 concentration/NFV concentration were significantly lower ( P < 0.05) in HIV+ and HCV+ subjects with cirrhosis (0.06 ± 0.074) than in the subjects in the other two groups. The mean ratios for M8 and NFV were not statistically different between HIV+ and HCV-negative patients (0.16 ± 0.13) and HIV+ and HCV+ patients without cirrhosis (0.24 ± 0.17), but the interpatient variability was high. Our results indicate that the pharmacokinetics of NFV and M8 are altered in HIV+ and HCV+ patients, especially those with liver cirrhosis. Therefore, there may be a role for therapeutic drug monitoring in individualizing the NFV dosage in HIV-HCV-coinfected patients.
Published: 2005

10. Corrigendum to 'Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment' [J Hepatol 48 (2008) 548–558]

Author: Giuseppe Pedrazzi, Barbara Amadei, Alessandra Orlandini, Maria Cristina Cavallo, Carlo Ferrari, D. Tola, Luca Sacchelli, Simona Urbani, and Gabriele Missale
Subjects: Hepatology, biology, business.industry, T cell, Viremia, medicine.disease, Virology, Blockade, medicine.anatomical_structure, PD-L1, biology.protein, Medicine, Antiviral treatment, business
Published: 2008

11. [94] PERSISTENT IMPAIRMENT OF HCV-SPECIFIC CDS CELL RESPONSE IN HCV-RNA NEGATIVE PATIENTS AFTER SUCCESSFUL PEG-INTERFERON/RIBAVIRIN TREATMENT

Author: C. Ferrari, Cristina Mori, Amalia Penna, Massimo Pilli, S. Mezzadri, Gabriele Missale, Luca Sacchelli, and Alessandro Zerbini
Subjects: Peg interferon, chemistry.chemical_compound, Hepatology, chemistry, business.industry, Ribavirin, Medicine, Cell response, business, Virology
Published: 2007

12. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Author: Abbas, Ali, Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Jabal, Kamal Abu, Zayyad, Hiba Abu, Acharya, Subhash, Acker, Andrew, Adachi, Shingo, Adam, Elisabeth, Adriano, Enrico, Adrião, Diana, Ageel, Saleh Al, Ahmed, Shakeel, Aiello, Marina, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Qasim, Eman Al, Al-dabbous, Tala, Al-Fares, Abdulrahman, Alalqam, Razi, Alberti, Angela, Alegesan, Senthilkumar, Alegre, Cynthia, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Alfoudri, Huda, Ali, Adam, Ali, Imran, Shah, Naseem Ali, Sheikh, Naseem Ali, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Altaf, Aneela, Alves, João, Alves, João Melo, Alves, Rita, Amaral, Maria, Amira, Nur, Ammerlaan, Heidi, Ampaw, Phoebe, Andini, Roberto, Andrejak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, de Brito, Carlos Alexandre Antunes, Anwar, Kazi Rubayet, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Aroca, Ana, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asaki, Motohiro, Asensio, Angel, Ashley, Elizabeth, Ashraf, Muhammad, Asif, Namra, Asim, Mohammad, Assie, Jean Baptiste, Asyraf, Amirul, Atique, Anika, Attanyake, A. M. Udara Lakshan, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Axelsen, Eyvind W., Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Bævre-Jensen, Roar, Baig, Nadia, Baillie, J. Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bal, Andriy, Balakrishnan, Mohanaprasanth, Balan, Valeria, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrasa, Helena, Barrelet, Audrey, Barrigoto, Cleide, Bartoli, Marie, Bartone, Cheryl, Baruch, Joaquín, Bashir, Mustehan, Basmaci, Romain, Basri, Muhammad Fadhli Hassin, Battaglini, Denise, Bauer, Jules, Rincon, Diego Fernando Bautista, Dow, Denisse Bazan, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beiruti, Karine, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Benkerrou, Dehbia, Bennett, Suzanne, Bento, Luís, Berdal, Jan-Erik, Bergeaud, Delphine, Bergin, Hazel, Sobrino, José Luis Bernal, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Betz, Adam, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianchi, Isabella, Bianco, Claudia, Bidin, Farah Nadiah, Singh, Moirangthem Bikram, Bin Humaid, Felwa, Bin Kamarudin, Mohd Nazlin, Bissuel, François, Biston, Patrick, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaarts, Alice, Bogaert, Debby, Boivin, Anne-Hélène, Bolze, Pierre-Adrien, Bompart, François, Bonelli, Patrizia, Bonfasius, Aurelius, Borges, Diogo, Borie, Raphaël, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Bounphiengsy, Thipsavanh, Bountthasavong, Latsaniphone, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Brandenburger, Timo, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Dorothy, Breen, Patrick, Brickell, Kathy, Browne, Alex, Browne, Shaunagh, Brozzi, Nicolas, Brunvoll, Sonja Hjellegjerde, Brusse-Keizer, Marjolein, Buchtele, Nina, Buesaquillo, Christian, Bugaeva, Polina, Buisson, Marielle, Buonsenso, Danilo, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Callahan, Mia, Calligy, Kate, Calvache, Jose Andres, Caminiti, Caterina, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Canepa, Cecilia, Cantero, Mireia, Caraux-Paz, Pauline, Cárcel, Sheila, Cardellino, Chiara Simona, Cardoso, Filipa, Cardoso, Filipe, Cardoso, Nelson, Cardoso, Sofia, Carelli, Simone, Carlacci, Francesca, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Carvalho, Leonor, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castrillón, Henry, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavalli, Giulio Giovanni, Cavayas, Alexandros, Ceccato, Adrian, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Auger, Christelle Chantalat, Chapplain, Jean-Marc, Chas, Julie, Chatterjee, Allegra, Chaudry, Mobin, Iñiguez, Jonathan Samuel Chávez, Chen, Anjellica, Chen, Yih-Sharng, Cheng, Matthew Pellan, Cheret, Antoine, Chetta, Alfredo Antonio, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Hwa Jin, Cho, Sung-Min, Cholley, Bernard, Chommanam, Danoy, Chopin, Marie-Charlotte, Chow, Ting Soo, Chow, Yock Ping, Christy, Nathaniel, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Herreros, José Miguel Cisneros, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Emma, Clarke, Jennifer, Granado, Rolando Claure-Del, Clohisey, Sara, Cobb, Perren J., Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connor, Marie, Conrad, Anne, Contreras, Sofía, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Costigan, Emma, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Cregan, Rachel, D’Orleans, Charles Crepy, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Berm, Juan Luis Cruz, Rojo, Jaime Cruz, Csete, Marc, Cucino, Alberto, Cullen, Ailbhe, Cummings, Matthew, Curley, Ger, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, D’Amico, Federico, D’Aragon, Frédérick, D’Ortenzio, Eric, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahl, John Arne, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A, Dantas, Jorge, de Boer, Mark, de Loughry, Gillian, de Mendoza, Diego, De Montmollin, Etienne, de Oliveira França, Rafael Freitas, Oliveira, Ana Isabel de Pinho, De Rosa, Rosanna, De Rose, Cristina, de Silva, Thushan, de Vries, Peter, Deacon, Jillian, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Delfos, Nathalie M., Deligiannis, Ionna, Dell’Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Dias, André, Dias, Andrea, Diaz, Juan Jose, Diaz, Priscila, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Dondorp, Arjen M, Dong, Andy, Donnelly, Christl A., Donnelly, Maria, Donohue, Chloe, Donohue, Sean, Donohue, Yoann, Doran, Peter, Dorival, Céline, Douangdala, Phouvieng, Douglas, James Joshua, Douma, Renee, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dror, Amiel A., Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Dubot-Pérès, Audrey, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham III, Lucian, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Economopoulos, Giorgio, Edelstein, Michael, Egan, Siobhan, Eggesbø, Linn Margrete, Eira, Carla, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Ellerbroek, Jacobien, Ellingjord-Dale, Merete, Eloy, Philippine, Elshazly, Tarek, Elyazar, Iqbal, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Fabre, Marc, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Fakar, Zul, Fareed, Komal, Faria, Pedro, Farooq, Ahmed, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferrari, Carlo, Ferraz, Mário, Ferreira, Benigno, Ferreira, Isabel, Ferreira, Sílvia, Ferrer-Roca, Ricard, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Finlayson, William, Fiorda, Juan, Flament, Thomas, Flateau, Clara, Fletcher, Tom, Florio, Letizia Lucia, Flynn, Brigid, Flynn, Deirdre, Fogliazza, Federica, Foley, Claire, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Fontela, Patricia, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, Christophe, Fraser, John F, Freire, Marcela Vieira, Ribeiro, Ana Freitas, French, Craig, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, Argin, G, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagné, Nathalie, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Curto, Elena Gallego, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Diaz, Julia, Garcia-Gallo, Esteban, Garimella, Navya, Garofalo, Federica, Garot, Denis, Garrait, Valérie, Gauli, Basanta, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghisulal, Praveen Kumar, Ghosn, Jade, Giani, Marco, Giaquinto, Carlo, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Gitaka, Jesse, Giwangkancana, Gezy, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goco, Geraldine, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gomes, Rui, Gomez, Kyle, Gómez-Junyent, Joan, Gominet, Marie, Gonçalves, Bronner P., Gonzalez, Alicia, Gordon, Patricia, Gorelik, Yanay, Gorenne, Isabelle, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Graf, Jeronimo, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Grazioli, Lorenzo, Green, Christopher A., Greene, Courtney, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Lordemann, Anja Grosse, Gruner, Heidi, Gu, Yusing, Guarracino, Fabio, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerguerian, Anne-Marie, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, de Castro, Maisa Guimarães, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hackmann, Amy, Hadri, Nadir, Haidri, Fakhir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hameed, Jawad, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammarström, Bato, Hammond, Terese, Han, Lim Yuen, Haniffa, Rashan, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Harrison, Samuel Bernard Ekow, Hartman, Alan, Hasan, Mohd Shahnaz, Hashmi, Junaid, Hashmi, Madiha, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles, Hentzien, Maxime, Hernandez-Montfort, Jaime, Herr, Daniel, Hershey, Andrew, Hesstvedt, Liv, Hidayah, Astarini, Higgins, Dawn, Higgins, Eibhilin, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hirkani, Haider, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Hoshino, Koji, Hoshino, Kota, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Hsu, Jimmy Ming-Yang, Hulot, Jean-Sébastien, Huo, Stella, Hussain, Iqbal, Ijaz, Samreen, Illes, Hajnal-Gabriela, Imbert, Patrick, Imran, Mohammad, Sikander, Rana Imran, Imtiaz, Aftab, Inácio, Hugo, Dominguez, Carmen Infante, Ing, Yun Sii, Iosifidis, Elias, Ippolito, Mariachiara, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Istre, Mette Stausland, Itai, Junji, Ito, Asami, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Jamieson, Nina, Jaquet, Pierre, Jassat, Waasila, Jaud-Fischer, Coline, Jaureguiberry, Stéphane, Javidfar, Jeffrey, Jaworsky, Denise, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Jimbo-Sotomayor, Ruth, Joe, Ong Yiaw, García, Ruth N. Jorge, Jørgensen, Silje Bakken, Joseph, Cédric, Joseph, Mark, Joshi, Swosti, Jourdain, Mercé, Jouvet, Philippe, June, Jennifer, Jung, Anna, Jung, Hanna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalicinska, Alina, Kalleberg, Karl Trygve, Kalomoiri, Smaragdi, Kamaluddin, Muhammad Aisar Ayadi, Kamaruddin, Zul Amali Che, Kamarudin, Nadiah, Kamineni, Kavita, Kandamby, Darshana Hewa, Kandel, Chris, Kang, Kong Yeow, Kanwal, Darakhshan, Kanyawati, Dyah, Karpayah, Pratap, Karsies, Todd, Kartsonaki, Christiana, Kasugai, Daisuke, Kataria, Anant, Katz, Kevin, Kaur, Aasmine, Kawasaki, Tatsuya, Kay, Christy, Keane, Hannah, Keating, Seán, Kedia, Pulak, Kelly, Andrea, Kelly, Aoife, Kelly, Claire, Kelly, Niamh, Kelly, Sadie, Kelly, Yvelynne, Kelsey, Maeve, Kennedy, Ryan, Kennon, Kalynn, Keomany, Sommay, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Kestelyn, Evelyne, Khalid, Imrana, Khalid, Osama, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Khan, Quratul Ain, Khanal, Sushil, Khatak, Abid, Khawaja, Amin, Kherajani, Krish, Kho, Michelle E., Khoo, Denisa, Khoo, Ryan, Khoo, Saye, Khoso, Nasir, Kiat, Khor How, Kida, Yuri, Kihuga, Harrison, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kim, Jae Burm, Kimmoun, Antoine, Kindgen-Milles, Detlef, King, Alexander, Kitamura, Nobuya, Kjetland, Eyrun Floerecke Kjetland, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R, Kobbe, Robin, Kodippily, Chamira, Vasconcelos, Malte Kohns, Koirala, Sabin, Komatsu, Mamoru, Korten, Volkan, Kosgei, Caroline, Kpangon, Arsène, Krawczyk, Karolina, Krishnan, Sudhir, Krishnan, Vinothini, Kruglova, Oksana, Kumar, Deepali, Kumar, Ganesh, Kumar, Mukesh, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kusumastuti, Neurinda Permata, Kutsogiannis, Demetrios, Kutsyna, Galyna, Kyriakoulis, Konstantinos, L’Her, Erwan, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lakhey, Sanjay, Lalueza, Antonio, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Lath, Sakshi, Latif, Naveed, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andrew, Law, Andy, Lawrence, Cassie, Lawrence, Teresa, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, Leal, Ema, Santos, Marta Leal, Lee, Biing Horng, Lee, Heng Gee, Lee, James, Lee, Su Hwan, Lee, Todd C., Lee, Yi Lin, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefevre, Benjamin, LeGac, Sylvie, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Lennon, Jenny, León, Rafael, Leone, Marc, Leone, Michela, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letizia, Andrew, Levy, Bruno, Levy, Yves, Levy-Marchal, Claire, Lewandowska, Katarzyna, Bassi, Gianluigi Li, Liang, Janet, Liaquat, Ali, Liegeon, Geoffrey, Lim, Kah Chuan, Lim, Wei Shen, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingad, Maja Katherine, Lingas, Guillaume, Lion-Daolio, Sylvie, Lissauer, Samantha, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Loforte, Antonio, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Lovelace-Macon, Lara, Low, Lee Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean Christophe, Bermejo, Carlos Lumbreras, Luna, Carlos M., Lungu, Olguta, Luong, Liem, Luque, Nestor, Luton, Dominique, Lwin, Nilar, Lyons, Ruth, Maasikas, Olavi, Mabiala, Oryane, MacDonald, Sarah, Machado, Moïse, Macheda, Gabriel, Sanchez, Juan Macias, Madhok, Jai, Madiha, Hashmi, de la Calle, Guillermo Maestro, Magara, Jacob, Maglietta, Giuseppe, Mahieu, Rafael, Mahy, Sophie, Maia, Ana Raquel, Maier, Lars S., Maillet, Mylène, Maitre, Thomas, Majori, Maria, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Maltez, Fernando, Malvy, Denis, Mammi, Patrizia, Manda, Victoria, Mandei, Jose M., Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Malaque, Ceila Maria Sant’Ana, Marino, Daniel, Marino, Flávio, Markowicz, Samuel, Eid, Charbel Maroun, Marques, Ana, Marquis, Catherine, Marsh, Brian, Marsh, Laura, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Dori-Ann, Martin, Emily, Martin-Blondel, Guillaume, Martin-Loeches, Ignacio, Martin-Quiros, Alejandro, Martinelli, Alessandra, Martinot, Martin, Martins, Ana, Martins, João, Martins, Nuno, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Jimenez, Juan Fernado Masa, Maslove, David, Mason, Phillip, Mason, Sabina, Masood, Sobia, Nor, Basri Mat, Matan, Moshe, Fernandes, Henrique Mateus, Mathew, Meghena, Mathieu, Daniel, Mattei, Mathieu, Matulevics, Romans, Maulin, Laurence, Maxwell, Michael, Maynar, Javier, Mayxay, Mayfong, Mazzoni, Thierry, Mc Evoy, Natalie, Mc Sweeney, Lisa, McArthur, Colin, McCarthy, Aine, McCarthy, Anne, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEneany, Victoria, McGeer, Allison, McKay, Chris, McKeown, Johnny, McLean, Kenneth A., McNally, Paul, McNicholas, Bairbre, McPartlan, Elaine, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Meher, Maqsood, Mehkri, Omar, Mele, Ferruccio, Melo, Luis, Memon, Kashif, Mendes, Joao, Menkiti, Ogechukwu, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Emmanuelle, Mercier, Noémie, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Merson, Laura, Meschi, Tiziana, Mesquita, António, Meta, Roberta, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelagnoli, Giuliano, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miranda-Maldonado, Hugo, Misnan, Nor Arisah, Mohamed, Nik Nur Eliza, Mohamed, Tahira Jamal, Moin, Asma, Molina, David, Molinos, Elena, Molloy, Brenda, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Sarah, Moore, Shona C., Cely, Lina Morales, Moro, Lucia, Tutillo, Diego Rolando Morocho, Morton, Ben, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Mufti, Aisha Kalsoom, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Muneeb, Syed, Munir, Nadeem, Munshi, Laveena, Murphy, Aisling, Murphy, Lorna, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Mutti, Carlotta, Muvindi, Himasha, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Mohd-Hanafiah, Farah Nadia, Nagpal, Dave, Narasimhan, Mangala, Narayanan, Nageswaran, Khan, Rashid Nasim, Nazerali-Maitland, Alasdair, Neant, Nadège, Neb, Holger, Necsoi, Coca, Nekliudov, Nikita A., Nelwan, Erni, Neto, Raul, Neumann, Emily, Neves, Bernardo, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Ngure, Jane, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nichol, Alistair, Nitayavardhana, Prompak, Nonas, Stephanie, Noordin, Nurul Amani Mohd, Noret, Marion, Norharizam, Nurul Faten Izzati, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nowicka, Karolina, Nowinski, Adam, Nseir, Saad, Nunez, Jose I., Nurnaningsih, Nurnaningsih, Nusantara, Dwi Utomo, Nyamankolly, Elsa, Nygaard, Anders Benteson, Brien, Fionnuala O., Callaghan, Annmarie O., O’Callaghan, Annmarie, O’Donnell, Max, O’Halloran, Sophie, O’Hearn, Katie, O’Neil, Conar, O’Shea, Linda, O’Sullivan, Miriam, Occhipinti, Giovanna, OConnor, Derbrenn, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, Ohshimo, Shinichiro, Oldakowska, Agnieszka, Oliveira, João, Oliveira, Larissa, Olliaro, Piero L., Ong, David S. Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orakzai, Saijad, Orozco-Chamorro, Claudia Milena, Orquera, Andrés, Ortoleva, Jamel, Osatnik, Javier, Othman, Siti Zubaidah, Otiku, Paul, Ouamara, Nadia, Ouissa, Rachida, Owyang, Clark, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palacios, Mario, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Paneru, Hem, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parducci, Paolo, Oña, Edwin Fernando Paredes, Parke, Rachael, Parker, Melissa, Parra, Briseida, Parrini, Vieri, Pasha, Taha, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Patel, Drashti, Pathmanathan, Mohan Dass, Patrão, Luís, Patricio, Patricia, Patrier, Juliette, Patrizi, Laura, Patterson, Lisa, Pattnaik, Rajyabardhan, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peariasamy, Kalaiarasu, Jiménez, Miguel Pedrera, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, 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Eoin, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Suzette, Williams, Virginie, Wils, Evert-Jan, Wong, Calvin, Wong, Teck Fung, Wong, Xin Ci, Wong, Yew Sing, Wright, Natalie, Xian, Gan Ee, Xian, Lim Saio, Xuan, Kuan Pei, Xynogalas, Ioannis, Yacoub, Sophie, Yakop, Siti Rohani Binti Mohd, Yamazaki, Masaki, Yazdanpanah, Yazdan, Hing, Nicholas Yee Liang, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yiaye, Touxiong, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Yuliarto, Saptadi, Zaaqoq, Akram, Zabbe, Marion, Zacharowski, Kai, Zahid, Masliza, Zahran, Maram, Zaidan, Nor Zaila Binti, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zawadka, Konrad, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Fryer, Daniel Vidali, Duque, Sara, Fuentes, Yuli V., Baruch, Joaquin, Beane, Abi, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), University of La Sabana = Universitad de la Sabana, University of Queensland [Brisbane], University of British Columbia (UBC), University of Oxford, The investigators acknowledge: This work is part of the Grand Challenges ICODA pilot initiative, delivered by Health Data Research UK and funded by the Bill & Melinda Gates Foundation and the Minderoo Foundation. The philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund, UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z and 220757/Z/20/Z], the Bill & Melinda Gates Foundation [OPP1209135], the National Institute for Health Research (NIHR, award CO-CIN-01), the Medical Research Council (MRC, grant MC_PC_19059), the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE)(award 200907), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013), NIHR Clinical Research Network (infrastructure support), CIHR Coronavirus Rapid Research Funding Opportunity OV2170359 and was coordinated out of Sunnybrook Research Institute, the endorsement of the Irish Critical Care- Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care- Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12], Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 project 101003589], European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313], COVID clinical management team, AIIMS, Rishikesh, India, Cambridge NIHR Biomedical Research Centre, the dedication and hard work of the Groote Schuur Hospital Covid ICU Team, the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town, Wellcome Trust fellowship [205228/Z/16/Z], the Liverpool School of Tropical Medicine, the University of Oxford, the dedication and hard work of the Norwegian SARS-CoV-2 study team, the Research Council of Norway grant no 312780, a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner, Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies, in-kind contribution, preparedness work conducted by the Short Period Incidence Study of Severe Acute Respiratory Infection, Stiftungsfonds zur Förderung der Bekämpfung der Tuberkulose und anderer Lungenkrankheiten of the City of Vienna, Project Number: APCOV22BGM, Italian Ministry of Health 'Fondi Ricerca corrente–L1P6' to IRCCS Ospedale Sacro Cuore–Don Calabria, Australian Department of Health grant (3273191), Gender Equity Strategic Fund at University of Queensland, Artificial Intelligence for Pandemics (A14PAN) at University of Queensland, the Australian Research Council Centre of Excellence for Engineered Quantum Systems (EQUS, CE170100009), the Prince Charles Hospital Foundation, Australia, UK Medical Research Council Clinical Research Training Fellowship MR/V001671/1, Instituto de Salud Carlos III, Ministerio de Ciencia, Spain, Brazil, National Council for Scientific and Technological Development Scholarship number 303953/2018-7, Firland Foundation, Shoreline, Washington, USA, the French COVID cohort (NCT04262921) is sponsored by INSERM and is funding by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC n°20-0424). This work uses Data/Material provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. ISARIC4C Investigators collated the COVID-19 Clinical Information Network (CO-CIN) data., European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Bill & Melinda Gates Foundation, Minderoo Foundation, Commonwealth Foundation, Wellcome Trust, National Institute for Health Research (UK), Medical Research Council (UK), University of Liverpool, Imperial College London, Canadian Institutes of Health Research, Sunnybrook Research Institute, Health Research Board (Ireland), European Commission, All India Institute of Medical Science, University of Cape Town, Research Council of Norway, Innovative Medicines Initiative, Governo Italiano, University of Queensland, Australian Research Council, Prince Charles Hospital Foundation, Instituto de Salud Carlos III, Institut National de la Santé et de la Recherche Médicale (France), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Garcia-Gallo, Esteban, Merson, Laura, Kennon, Kalynn, Kelly, Sadie, Citarella, Barbara Wanjiru, Fryer, Daniel Vidali, Shrapnel, Sally, Lee, Jame, Duque, Sara, Fuentes, Yuli V, Balan, Valeria, Smith, Sue, Wei, Jia, Gonçalves, Bronner P, Russell, Clark D, Sigfrid, Louise, Dagens, Andrew, Olliaro, Piero L, Baruch, Joaquin, Kartsonaki, Christiana, Dunning, Jake, Rojek, Amanda, Rashan, Aasiyah, Beane, Abi, Murthy, Sriniva, Reyes, Luis Felipe, ISARIC Clinical Characterization Group: Ali Abbas, Sheryl Ann Abdukahil, Nurul Najmee Abdulkadir, Ryuzo Abe, Laurent Abel, Lara Absil, Kamal Abu Jabal, Hiba Abu Zayyad, Subhash Acharya, Andrew Acker, Shingo Adachi, Elisabeth Adam, Enrico Adriano, Diana Adrião, Saleh Al Ageel, Shakeel Ahmed, Marina Aiello, Kate Ainscough, Eka Airlangga, Tharwat Aisa, Ali Ait Hssain, Younes Ait Tamlihat, Takako Akimoto, Ernita Akmal, Eman Al Qasim, Tala Al-Dabbous, Abdulrahman Al-Fares, Razi Alalqam, Angela Alberti, Senthilkumar Alegesan, Cynthia Alegre, Marta Alessi, Beatrice Alex, Kévin Alexandre, Huda Alfoudri, Adam Ali, Imran Ali, Naseem Ali Shah, Naseem Ali Sheikh, Kazali Enagnon Alidjnou, Jeffrey Aliudin, Qabas Alkhafajee, Clotilde Allavena, Nathalie Allou, Aneela Altaf, João Alves, João Melo Alves, Rita Alves, Maria Amaral, Nur Amira, Heidi Ammerlaan, Phoebe Ampaw, Roberto Andini, Claire Andrejak, Andrea Angheben, François Angoulvant, Séverine Ansart, Sivanesen Anthonidass, Massimo Antonelli, Carlos Alexandre Antunes de Brito, Kazi Rubayet Anwar, Ardiyan Apriyana, Yaseen Arabi, Irene Aragao, Francisco Arancibia, Carolline Araujo, Antonio Arcadipane, Patrick Archambault, Lukas Arenz, Jean-Benoît Arlet, Christel Arnold-Day, Ana Aroca, Lovkesh Arora, Rakesh Arora, Elise Artaud-Macari, Diptesh Aryal, Motohiro Asaki, Angel Asensio, Elizabeth Ashley, Muhammad Ashraf, Namra Asif, Mohammad Asim, Jean Baptiste Assie, Amirul Asyraf, Anika Atique, A M Udara Lakshan Attanyake, Johann Auchabie, Hugues Aumaitre, Adrien Auvet, Eyvind W Axelsen, Laurène Azemar, Cecile Azoulay, Benjamin Bach, Delphine Bachelet, Claudine Badr, Roar Bævre-Jensen, Nadia Baig, J Kenneth Baillie, J Kevin Baird, Erica Bak, Agamemnon Bakakos, Nazreen Abu Bakar, Andriy Bal, Mohanaprasanth Balakrishnan, Valeria Balan, Firouzé Bani-Sadr, Renata Barbalho, Nicholas Yuri Barbosa, Wendy S Barclay, Saef Umar Barnett, Michaela Barnikel, Helena Barrasa, Audrey Barrelet, Cleide Barrigoto, Marie Bartoli, Cheryl Bartone, Joaquín Baruch, Mustehan Bashir, Romain Basmaci, Muhammad Fadhli Hassin Basri, Denise Battaglini, Jules Bauer, Diego Fernando Bautista Rincon, Denisse Bazan Dow, Abigail Beane, Alexandra Bedossa, Ker Hong Bee, Husna Begum, Sylvie Behilill, Karine Beiruti, Albertus Beishuizen, Aleksandr Beljantsev, David Bellemare, Anna Beltrame, Beatriz Amorim Beltrão, Marine Beluze, Nicolas Benech, Lionel Eric Benjiman, Dehbia Benkerrou, Suzanne Bennett, Luís Bento, Jan-Erik Berdal, Delphine Bergeaud, Hazel Bergin, José Luis Bernal Sobrino, Giulia Bertoli, Lorenzo Bertolino, Simon Bessis, Adam Betz, Sybille Bevilcaqua, Karine Bezulier, Amar Bhatt, 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Sebastiano Maria Colombo, Pamela Combs, Marie Connor, Anne Conrad, Sofía Contreras, Elaine Conway, Graham S Cooke, Mary Copland, Hugues Cordel, Amanda Corley, Sabine Cornelis, Alexander Daniel Cornet, Arianne Joy Corpuz, Andrea Cortegiani, Grégory Corvaisier, Emma Costigan, Camille Couffignal, Sandrine Couffin-Cadiergues, Roxane Courtois, Stéphanie Cousse, Rachel Cregan, Charles Crepy D'Orleans, Sabine Croonen, Gloria Crowl, Jonathan Crump, Claudina Cruz, Juan Luis Cruz Berm, Jaime Cruz Rojo, Marc Csete, Alberto Cucino, Ailbhe Cullen, Matthew Cummings, Ger Curley, Gerard Curley, Elodie Curlier, Colleen Curran, Paula Custodio, Federico D'Amico, Frédérick D'Aragon, Eric D'Ortenzio, Ana da Silva Filipe, Charlene Da Silveira, Al-Awwab Dabaliz, Andrew Dagens, John Arne Dahl, Darren Dahly, Heidi Dalton, Jo Dalton, Seamus Daly, Nick Daneman, Corinne Daniel, Emmanuelle A Dankwa, Jorge Dantas, Mark de Boer, Gillian de Loughry, Diego de Mendoza, Etienne De Montmollin, Rafael Freitas de Oliveira 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Phouvieng Douangdala, James Joshua Douglas, Renee Douma, Nathalie Dournon, Triona Downer, Joanne Downey, Mark Downing, Tom Drake, Aoife Driscoll, Amiel A Dror, Murray Dryden, Claudio Duarte Fonseca, Vincent Dubee, François Dubos, Audrey Dubot-Pérès, Alexandre Ducancelle, Toni Duculan, Susanne Dudman, Abhijit Duggal, Paul Dunand, Jake Dunning, Mathilde Duplaix, Emanuele Durante-Mangoni, Lucian Durham 3rd, Bertrand Dussol, Juliette Duthoit, Xavier Duval, Anne Margarita Dyrhol-Riise, Sim Choon Ean, Marco Echeverria-Villalobos, Giorgio Economopoulos, Michael Edelstein, Siobhan Egan, Linn Margrete Eggesbø, Carla Eira, Mohammed El Sanharawi, Subbarao Elapavaluru, Brigitte Elharrar, Jacobien Ellerbroek, Merete Ellingjord-Dale, Philippine Eloy, Tarek Elshazly, Iqbal Elyazar, Isabelle Enderle, Tomoyuki Endo, Chan Chee Eng, Ilka Engelmann, Vincent Enouf, Olivier Epaulard, Martina Escher, Mariano Esperatti, Hélène Esperou, Marina Esposito-Farese, João Estevão, Manuel Etienne, Nadia Ettalhaoui, Anna Greti Everding, Mirjam Evers, Isabelle Fabre, Marc Fabre, Amna Faheem, Arabella Fahy, Cameron J Fairfield, Zul Fakar, Komal Fareed, Pedro Faria, Ahmed Farooq, Hanan Fateena, Arie Zainul Fatoni, Karine Faure, Raphaël Favory, Mohamed Fayed, Niamh Feely, Laura Feeney, Jorge Fernandes, Marília Andreia Fernandes, Susana Fernandes, François-Xavier Ferrand, Eglantine Ferrand Devouge, Joana Ferrão, Carlo Ferrari, Mário Ferraz, Benigno Ferreira, Isabel Ferreira, Sílvia Ferreira, Ricard Ferrer-Roca, Nicolas Ferriere, Céline Ficko, Claudia Figueiredo-Mello, William Finlayson, Juan Fiorda, Thomas Flament, Clara Flateau, Tom Fletcher, Letizia Lucia Florio, Brigid Flynn, Deirdre Flynn, Federica Fogliazza, Claire Foley, Jean Foley, Victor Fomin, Tatiana Fonseca, Patricia Fontela, Simon Forsyth, Denise Foster, Giuseppe Foti, Erwan Fourn, Robert A Fowler, Marianne Fraher, Diego Franch-Llasat, Christophe Fraser, John F Fraser, Marcela Vieira Freire, Ana Freitas Ribeiro, Craig French, Caren Friedrich, Ricardo Fritz, Stéphanie Fry, Nora Fuentes, Masahiro Fukuda, G Argin, Valérie Gaborieau, Rostane Gaci, Massimo Gagliardi, Jean-Charles Gagnard, Nathalie Gagné, Amandine Gagneux-Brunon, Sérgio Gaião, Linda Gail Skeie, Phil Gallagher, Elena Gallego Curto, Carrol Gamble, Yasmin Gani, Arthur Garan, Rebekha Garcia, Noelia García Barrio, Julia Garcia-Diaz, Esteban Garcia-Gallo, Navya Garimella, Federica Garofalo, Denis Garot, Valérie Garrait, Basanta Gauli, Nathalie Gault, Aisling Gavin, Anatoliy Gavrylov, Alexandre Gaymard, Johannes Gebauer, Eva Geraud, Louis Gerbaud Morlaes, Nuno Germano, Praveen Kumar Ghisulal, Jade Ghosn, Marco Giani, Carlo Giaquinto, Jess Gibson, Tristan Gigante, Morgane Gilg, Elaine Gilroy, Guillermo Giordano, Michelle Girvan, Valérie Gissot, Jesse Gitaka, Gezy Giwangkancana, Daniel Glikman, Petr Glybochko, Eric Gnall, Geraldine Goco, François Goehringer, Siri Goepel, Jean-Christophe Goffard, Jin Yi Goh, Jonathan Golob, Rui Gomes, Kyle Gomez, Joan Gómez-Junyent, Marie Gominet, Bronner P Gonçalves, Alicia Gonzalez, Patricia Gordon, Yanay Gorelik, Isabelle Gorenne, Laure Goubert, Cécile Goujard, Tiphaine Goulenok, Margarite Grable, Jeronimo Graf, Edward Wilson Grandin, Pascal Granier, Giacomo Grasselli, Lorenzo Grazioli, Christopher A Green, Courtney Greene, William Greenhalf, Segolène Greffe, Domenico Luca Grieco, Matthew Griffee, Fiona Griffiths, Ioana Grigoras, Albert Groenendijk, Anja Grosse Lordemann, Heidi Gruner, Yusing Gu, Fabio Guarracino, Jérémie Guedj, Martin Guego, Dewi Guellec, Anne-Marie Guerguerian, Daniela Guerreiro, Romain Guery, Anne Guillaumot, Laurent Guilleminault, Maisa Guimarães de Castro, Thomas Guimard, Marieke Haalboom, Daniel Haber, Hannah Habraken, Ali Hachemi, Amy Hackmann, Nadir Hadri, Fakhir Haidri, Sheeba Hakak, Adam Hall, Matthew Hall, Sophie Halpin, Jawad Hameed, Ansley Hamer, Raph L Hamers, Rebecca Hamidfar, Bato Hammarström, Terese Hammond, Lim Yuen Han, Rashan Haniffa, Kok Wei Hao, Hayley Hardwick, Ewen M Harrison, Janet Harrison, Samuel Bernard Ekow Harrison, Alan Hartman, Mohd Shahnaz Hasan, Junaid Hashmi, Madiha Hashmi, Ailbhe Hayes, Leanne Hays, Jan Heerman, Lars Heggelund, Ross Hendry, Martina Hennessy, Aquiles Henriquez-Trujillo, Maxime Hentzien, Jaime Hernandez-Montfort, Daniel Herr, Andrew Hershey, Liv Hesstvedt, Astarini Hidayah, Dawn Higgins, Eibhilin Higgins, Rita Hinchion, Samuel Hinton, Hiroaki Hiraiwa, Haider Hirkani, Hikombo Hitoto, Antonia Ho, Yi Bin Ho, Alexandre Hoctin, Isabelle Hoffmann, Wei Han Hoh, Oscar Hoiting, Rebecca Holt, Jan Cato Holter, Peter Horby, Juan Pablo Horcajada, Koji Hoshino, Kota Hoshino, Ikram Houas, Catherine L Hough, Stuart Houltham, Jimmy Ming-Yang Hsu, Jean-Sébastien Hulot, Stella Huo, Iqbal Hussain, Samreen Ijaz, Hajnal-Gabriela Illes, Patrick Imbert, Mohammad Imran, Rana Imran Sikander, Aftab Imtiaz, Hugo Inácio, Carmen Infante Dominguez, Yun Sii Ing, Elias Iosifidis, Mariachiara Ippolito, Sarah Isgett, Tiago Isidoro, Nadiah 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Nilar Lwin, Ruth Lyons, Olavi Maasikas, Oryane Mabiala, Sarah MacDonald, Moïse Machado, Gabriel Macheda, Juan Macias Sanchez, Jai Madhok, Hashmi Madiha, Guillermo Maestro de la Calle, Jacob Magara, Giuseppe Maglietta, Rafael Mahieu, Sophie Mahy, Ana Raquel Maia, Lars S Maier, Mylène Maillet, Thomas Maitre, Maria Majori, Maximilian Malfertheiner, Nadia Malik, Paddy Mallon, Fernando Maltez, Denis Malvy, Patrizia Mammi, Victoria Manda, Jose M Mandei, Laurent Mandelbrot, Frank Manetta, Julie Mankikian, Edmund Manning, Aldric Manuel, Ceila Maria Sant'Ana Malaque, Daniel Marino, Flávio Marino, Samuel Markowicz, Charbel Maroun Eid, Ana Marques, Catherine Marquis, Brian Marsh, Laura Marsh, Megan Marshal, John Marshall, Celina Turchi Martelli, Dori-Ann Martin, Emily Martin, Guillaume Martin-Blondel, Ignacio Martin-Loeches, Alejandro Martin-Quiros, Alessandra Martinelli, Martin Martinot, Ana Martins, João Martins, Nuno Martins, Caroline Martins Rego, Gennaro Martucci, Olga Martynenko, Eva Miranda Marwali, Marsilla Marzukie, Juan Fernado Masa Jimenez, David Maslove, Phillip Mason, Sabina Mason, Sobia Masood, Basri Mat Nor, Moshe Matan, Henrique Mateus Fernandes, Meghena Mathew, Daniel Mathieu, Mathieu Mattei, Romans Matulevics, Laurence Maulin, Michael Maxwell, Javier Maynar, Mayfong Mayxay, Thierry Mazzoni, Natalie Mc Evoy, Lisa Mc Sweeney, Colin McArthur, Aine McCarthy, Anne McCarthy, Colin McCloskey, Rachael McConnochie, Sherry McDermott, Sarah E McDonald, Aine McElroy, Samuel McElwee, Victoria McEneany, Allison McGeer, Chris McKay, Johnny McKeown, Kenneth A McLean, Paul McNally, Bairbre McNicholas, Elaine McPartlan, Edel Meaney, Cécile Mear-Passard, Maggie Mechlin, Maqsood Meher, Omar Mehkri, Ferruccio Mele, Luis Melo, Kashif Memon, Joao Mendes, Ogechukwu Menkiti, Kusum Menon, France Mentré, Alexander J Mentzer, Emmanuelle Mercier, Noémie Mercier, Antoine Merckx, Mayka Mergeay-Fabre, Blake Mergler, Laura Merson, Tiziana Meschi, António Mesquita, Roberta Meta, Osama 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Marta Sousa, Maria Sousa Uva, Vicente Souza-Dantas, Alexandra Sperry, Elisabetta Spinuzza, B P Sanka Ruwan Sri Darshana, Shiranee Sriskandan, Sarah Stabler, Thomas Staudinger, Stephanie-Susanne Stecher, Trude Steinsvik, Ymkje Stienstra, Birgitte Stiksrud, Eva Stolz, Amy Stone, Adrian Streinu-Cercel, Anca Streinu-Cercel, Samantha Strudwick, Ami Stuart, David Stuart, Decy Subekti, Gabriel Suen, Jacky Y Suen, Asfia Sultana, Charlotte Summers, Dubravka Supic, Deepashankari Suppiah, Magdalena Surovcová, Suwarti Suwarti, Andrey A Svistunov, Sarah Syahrin, Konstantinos Syrigos, Jaques Sztajnbok, Konstanty Szuldrzynski, Shirin Tabrizi, Fabio S Taccone, Lysa Tagherset, Shahdattul Mawarni Taib, Ewa Talarek, Sara Taleb, Jelmer Talsma, Renaud Tamisier, Maria Lawrensia Tampubolon, Kim Keat Tan, Le Van Tan, Yan Chyi Tan, Clarice Tanaka, Hiroyuki Tanaka, Taku Tanaka, Hayato Taniguchi, Huda Taqdees, Arshad Taqi, Coralie Tardivon, Pierre Tattevin, M Azhari Taufik, Hassan Tawfik, Richard S Tedder, Tze Yuan Tee, João Teixeira, Sofia Tejada, Marie-Capucine Tellier, Sze Kye Teoh, Vanessa Teotonio, François Téoulé, Pleun Terpstra, Olivier Terrier, Nicolas Terzi, Hubert Tessier-Grenier, Adrian Tey, Alif Adlan Mohd Thabit, Anand Thakur, Zhang Duan Tham, Suvintheran Thangavelu, Vincent Thibault, Simon-Djamel Thiberville, Benoît Thill, Jananee Thirumanickam, Shaun Thompson, David Thomson, Emma C Thomson, Surain Raaj Thanga Thurai, Duong Bich Thuy, Ryan S Thwaites, Andrea Ticinesi, Paul Tierney, Vadim Tieroshyn, Peter S Timashev, Jean-François Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Noémie Tissot, Jordan Zhien Yang Toh, Maria Toki, Kristian Tonby, Sia Loong Tonnii, Antoni Torres, Margarida Torres, Rosario Maria Torres Santos-Olmo, Hernando Torres-Zevallos, Michael Towers, Tony Trapani, Théo Treoux, Huynh Trung Trieu, Cécile Tromeur, Ioannis Trontzas, Tiffany Trouillon, Jeanne Truong, Christelle Tual, Sarah Tubiana, Helen Tuite, Jean-Marie Turmel, Lance C W Turtle, Anders Tveita, Pawel Twardowski, Makoto Uchiyama, P G Ishara Udayanga, Andrew Udy, Roman Ullrich, Alberto Uribe, Asad Usman, Timothy M Uyeki, Cristinava Vajdovics, Luís Val-Flores, Piero Valentini, Ana Luiza Valle, Amélie Valran, Ilaria Valzano, Stijn Van de Velde, Marcel van den Berge, Machteld Van der Feltz, Job van der Palen, Paul van der Valk, Nicky Van Der Vekens, Peter Van der Voort, Sylvie Van Der Werf, Marlice van Dyk, Laura van Gulik, Jarne Van Hattem, Carolien van Netten, Gitte Van Twillert, Ilonka van Veen, Noémie Vanel, Henk Vanoverschelde, Pooja Varghese, Michael Varrone, Shoban Raj Vasudayan, Charline Vauchy, Shaminee Veeran, Aurélie Veislinger, Sebastian Vencken, Sara Ventura, Annelies Verbon, James Vickers, José Ernesto Vidal, César Vieira, Deepak Vijayan, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Gayatri Vishwanathan, Benoit Visseaux, Hannah Visser, Chiara Vitiello, Manivanh Vongsouvath, Harald Vonkeman, Fanny Vuotto, Noor Hidayu Wahab, Suhaila Abdul Wahab, Nadirah Abdul Wahid, Marina Wainstein, Wan Fadzlina Wan Muhd Shukeri, Chih-Hsien Wang, Steve Webb, Jia Wei, Katharina Weil, Tan Pei Wen, Sanne Wesselius, T Eoin West, Murray Wham, Bryan Whelan, Nicole White, Paul Henri Wicky, Aurélie Wiedemann, Surya Otto Wijaya, Keith Wille, Suzette Willems, Virginie Williams, Evert-Jan Wils, Calvin Wong, Teck Fung Wong, Xin Ci Wong, Yew Sing Wong, Natalie Wright, Gan Ee Xian, Lim Saio Xian, Kuan Pei Xuan, Ioannis Xynogalas, Sophie Yacoub, Siti Rohani Binti Mohd Yakop, Masaki Yamazaki, Yazdan Yazdanpanah, Nicholas Yee Liang Hing, Cécile Yelnik, Chian Hui Yeoh, Stephanie Yerkovich, Touxiong Yiaye, Toshiki Yokoyama, Hodane Yonis, Obada Yousif, Saptadi Yuliarto, Akram Zaaqoq, Marion Zabbe, Kai Zacharowski, Masliza Zahid, Maram Zahran, Nor Zaila Binti Zaidan, Maria Zambon, Miguel Zambrano, Alberto Zanella, Konrad Zawadka, Nurul Zaynah, Hiba Zayyad, Alexander Zoufaly, David Zucman, Durante-Mangoni, Emanuele, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Microbes in Health and Disease (MHD), Garcia-Gallo E., Merson L., Kennon K., Kelly S., Citarella B. W. , Fryer D. V. , Shrapnel S., Lee J., Duque S., Fuentes Y. V. , et al., and Medical Microbiology & Infectious Diseases
Subjects: Eğitim, Social Sciences and Humanities, Information Security and Reliability, Social Sciences (SOC), Sosyal Bilimler ve Beşeri Bilimler, Epidemiology, EDUCATION & EDUCATIONAL RESEARCH, Temel Bilimler (SCI), BİLGİSAYAR BİLİMİ, BİLGİ SİSTEMLERİ, MATHEMATICS, Sociology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Prospective Studies, COMPUTER SCIENCE, INFORMATION SYSTEMS, STATISTICS & PROBABILITY, Matematik, Bilgisayar Bilimi Uygulamaları, Computer Sciences, Bilgi Güvenliği ve Güvenilirliği, EĞİTİM VE EĞİTİM ARAŞTIRMASI, BİLGİ BİLİMİ VE KÜTÜPHANE BİLİMİ, Bilgi sistemi, Computer Science Applications, Kütüphane ve Bilgi Bilimleri, Hospitalization, Natural Sciences (SCI), Physical Sciences, Engineering and Technology, Sosyal Bilimler (SOC), Bilgisayar Bilimi, Statistics, Probability and Uncertainty, Information Systems, Human, Statistics and Probability, Humans, Pandemics, SARS-CoV-2, COVID-19, SOCIAL SCIENCES, GENERAL, Library and Information Sciences, Education, SDG 3 - Good Health and Well-being, Library Sciences, INFORMATION SCIENCE & LIBRARY SCIENCE, İstatistik ve Olasılık, Sosyal ve Beşeri Bilimler, Bilgisayar Bilimleri, Social Sciences & Humanities, Engineering, Computing & Technology (ENG), Sosyoloji, Pandemic, İSTATİSTİK & OLASILIK, Mühendislik, Bilişim ve Teknoloji (ENG), İstatistik, Olasılık ve Belirsizlik, Sosyal Bilimler Genel, COMPUTER SCIENCE, Prospective Studie, Fizik Bilimleri, Viral infection, Mühendislik ve Teknoloji, Kütüphanecilik
Abstract: The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use., This work is part of the Grand Challenges ICODA pilot initiative, delivered by Health Data Research UK and funded by the Bill & Melinda Gates Foundation and the Minderoo Foundation. The philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund; UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z and 220757/Z/20/Z]; the Bill & Melinda Gates Foundation [OPP1209135]; the National Institute for Health Research (NIHR; award CO-CIN-01); the Medical Research Council (MRC; grant MC_PC_19059); the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE)(award 200907); NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927); Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153); NIHR Biomedical Research Centre at Imperial College London (award IS-BRC-1215-20013); NIHR Clinical Research Network (infrastructure support); CIHR Coronavirus Rapid Research Funding Opportunity OV2170359 and was coordinated out of Sunnybrook Research Institute; the endorsement of the Irish Critical Care- Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care- Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]; Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 project 101003589]; European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; COVID clinical management team, AIIMS, Rishikesh, India; Cambridge NIHR Biomedical Research Centre; the dedication and hard work of the Groote Schuur Hospital Covid ICU Team; the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; Wellcome Trust fellowship [205228/Z/16/Z]; the Liverpool School of Tropical Medicine; the University of Oxford; the dedication and hard work of the Norwegian SARS-CoV-2 study team; the Research Council of Norway grant no 312780; a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies, in-kind contribution; preparedness work conducted by the Short Period Incidence Study of Severe Acute Respiratory Infection; Stiftungsfonds zur Förderung der Bekämpfung der Tuberkulose und anderer Lungenkrankheiten of the City of Vienna, Project Number: APCOV22BGM; Italian Ministry of Health “Fondi Ricerca corrente–L1P6” to IRCCS Ospedale Sacro Cuore–Don Calabria; Australian Department of Health grant (3273191); Gender Equity Strategic Fund at University of Queensland; Artificial Intelligence for Pandemics (A14PAN) at University of Queensland; the Australian Research Council Centre of Excellence for Engineered Quantum Systems (EQUS, CE170100009); the Prince Charles Hospital Foundation, Australia; UK Medical Research Council Clinical Research Training Fellowship MR/V001671/1; Instituto de Salud Carlos III, Ministerio de Ciencia, Spain; Brazil, National Council for Scientific and Technological Development Scholarship number 303953/2018-7; Firland Foundation, Shoreline, Washington, USA; the French COVID cohort (NCT04262921) is sponsored by INSERM and is funding by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC n°20-0424).
Published: 2022

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12 results on '"Luca Sacchelli"'

1. Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

2. Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

3. Early kinetics of innate and adaptive immune responses during hepatitis B virus infection

4. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment

5. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses

6. Limited Sampling Strategy for the Estimation of Systemic Exposure to the Protease Inhibitor Nelfinavir

7. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B

8. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

9. Clinical pharmacokinetics of nelfinavir and its metabolite M8 in human immunodeficiency virus (HIV)-positive and HIV-hepatitis C virus-coinfected subjects

10. Corrigendum to 'Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment' [J Hepatol 48 (2008) 548–558]

11. [94] PERSISTENT IMPAIRMENT OF HCV-SPECIFIC CDS CELL RESPONSE IN HCV-RNA NEGATIVE PATIENTS AFTER SUCCESSFUL PEG-INTERFERON/RIBAVIRIN TREATMENT

12. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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