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1. Selective Internal Radiation Combined with Chemotherapy Maintains the Quality of Life in Intrahepatic Cholangiocarcinomas

Author: Camille Goislard de Monsabert, Yann Touchefeu, Boris Guiu, Boris Campillo-Gimenez, Olivier Farges, David Tougeron, Isabelle Baumgaertner, Ahmet Ayav, Luc Beuzit, Marc Pracht, Astrid Lièvre, Samuel Le Sourd, Karim Boudjema, Yan Rolland, Etienne Garin, Eveline Boucher, and Julien Edeline
Subjects: biliary tract cancer, radioembolization, Yttrium-90, chemotherapy, patient-reported outcomes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: In the Yttrium-90 Microspheres in Cholangiocarcinoma (MISPHEC) single-arm phase 2 trial, concomitant chemotherapy and selective internal radiotherapy (SIRT) showed antitumor activity as a first-line treatment of unresectable intrahepatic cholangiocarcinomas (ICCs). In this sub-analysis, we aimed to evaluate one of the secondary endpoints, the health-related quality of life (QoL), evaluated with an EORTC QLQ-C30 instrument at the baseline and during treatment. Methods: The MISPHEC trial included treatment-naïve patients with an unresectable ICC between November 2013 and June 2016. Patients received concomitant first-line chemotherapy with cisplatin and gemcitabine for 8 cycles; SIRT was administered during cycle 1 (for patients with unilobar disease) or cycles 1 and 3 (for patients with bilobar disease) using glass Yttrium-90 microspheres. We evaluated the QoL—measured by the QLQ-C30 questionnaire—at the baseline, every 8 weeks during chemotherapy and follow-up, between 12 and 15 weeks after embolization and every 12 weeks after a liver resection if applicable. Results: A total of 41 patients were included, of which 34 completed questionnaires at the baseline. No clinically significant changes in the global health score or the sub-scales of the QLQ-C30 were observed during follow-up. The physical, social and role function mean score worsened during treatment and fatigue, nausea and pain scores increased although the differences were not clinically significant. In patients undergoing subsequent surgery, the QoL was not impaired. Conclusions: A combination of SIRT and chemotherapy with gemcitabine and cisplatin as the first-line treatment of unresectable ICCs was found to maintain the QoL.
Published: 2021
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2. Design of haptic guides for pre-positioning assistance of a comanipulated needle.

Author: Hadrien Gurnel, Maud Marchal, Laurent Launay, Luc Beuzit, and Alexandre Krupa
Published: 2019
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3. Selective Internal Radiation Combined with Chemotherapy Maintains the Quality of Life in Intrahepatic Cholangiocarcinomas

Author: Etienne Garin, Yan Rolland, Luc Beuzit, Camille Goislard de Monsabert, Eveline Boucher, Astrid Lièvre, Yann Touchefeu, Samuel Le Sourd, David Tougeron, Karim Boudjema, Boris Campillo-Gimenez, Isabelle Baumgaertner, Olivier Farges, Ahmet Ayav, Marc Pracht, Julien Edeline, Boris Guiu, CRLCC Eugène Marquis (CRLCC), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Poitiers (CHU Poitiers), CRHU Nancy, CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), BTG, Ligue Contre le Cancer, Université de Montpellier (UM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Jonchère, Laurent, and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)
Subjects: vomiting, Yttrium-90, medicine.medical_treatment, insomnia, Brachytherapy, diarrhea, cisplatin, thrombocytopenia, chemotherapy, Gastroenterology, 030218 nuclear medicine & medical imaging, chemoradiotherapy, Cholangiocarcinoma, 0302 clinical medicine, Quality of life, dose response, pain, Embolization, RC254-282, clinical article, adult, gemcitabine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, yttrium 90, nausea, humanities, 3. Good health, sirtuin, aged, female, anorexia, patient-reported outcomes, 030220 oncology & carcinogenesis, liver resection, [SDV.IB]Life Sciences [q-bio]/Bioengineering, medicine.symptom, medicine.drug, radioembolization, medicine.medical_specialty, Nausea, patient-reported outcome, Article, multiple cycle treatment, 03 medical and health sciences, male, Internal medicine, biliary tract cancer, medicine, follow up, neutropenia, Humans, human, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Cisplatin, loss of appetite, Chemotherapy, business.industry, questionnaire, constipation, dyspnea, Gemcitabine, Radiation therapy, phase 2 clinical trial, multicenter study, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Concomitant, microsphere, Quality of Life, fatigue, asthenia, bile duct carcinoma, business
Abstract: Background: In the Yttrium-90 Microspheres in Cholangiocarcinoma (MISPHEC) single-arm phase 2 trial, concomitant chemotherapy and selective internal radiotherapy (SIRT) showed antitumor activity as a first-line treatment of unresectable intrahepatic cholangiocarcinomas (ICCs). In this sub-analysis, we aimed to evaluate one of the secondary endpoints, the health-related quality of life (QoL), evaluated with an EORTC QLQ-C30 instrument at the baseline and during treatment. Methods: The MISPHEC trial included treatment-naïve patients with an unresectable ICC between November 2013 and June 2016. Patients received concomitant first-line chemotherapy with cisplatin and gemcitabine for 8 cycles, SIRT was administered during cycle 1 (for patients with unilobar disease) or cycles 1 and 3 (for patients with bilobar disease) using glass Yttrium-90 microspheres. We evaluated the QoL—measured by the QLQ-C30 questionnaire—at the baseline, every 8 weeks during chemotherapy and follow-up, between 12 and 15 weeks after embolization and every 12 weeks after a liver resection if applicable. Results: A total of 41 patients were included, of which 34 completed questionnaires at the baseline. No clinically significant changes in the global health score or the sub-scales of the QLQ-C30 were observed during follow-up. The physical, social and role function mean score worsened during treatment and fatigue, nausea and pain scores increased although the differences were not clinically significant. In patients undergoing subsequent surgery, the QoL was not impaired. Conclusions: A combination of SIRT and chemotherapy with gemcitabine and cisplatin as the first-line treatment of unresectable ICCs was found to maintain the QoL.
Published: 2021

4. Connecting SPHERE and CRIRES+ for the characterisation of young exoplanets at high spectral resolution: status update of VLT/HiRISE

Author: Arthur Vigan, Maxime Lopez, Mona El Morsy, Eduard R. Muslimov, Alexandre Viret, Gérard Zins, Graham J. Murray, Anne Costille, Gilles P. P. L. Otten, Ulf Seemann, Heiko Anwand-Heerwart, Kjetil Dohlen, Patrick Blanchard, José Garcia, Yannick Charles, Nicolas Tchoubaklian, Timothé Ely, Mark Phillips, Jérôme Paufique, Jean-Luc Beuzit, Mathis Houllé, Jean Costes, Raphaël Pourcelot, Isabelle Baraffe, Reinhold Dorn, Marc Jaquet, Markus Kasper, Ansgar Reiners, Alain Smette, Leonardo Blanco, Laurent Pallanca, Alexis Carlotti, Elodie Choquet, David Mouillet, Mamadou N'Diaye, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Universidad ORT Uruguay, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Université Côte d'Azur - École universitaire de recherche Odyssée - Sciences de la société et de l'environnement (UCA EUR SSE), and Université Côte d'Azur (UCA)
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), High-dispersion coronagraphy, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Characterisation, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Exoplanet, VLT, High-contrast imaging, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Spectroscopy, Astrophysics::Galaxy Astrophysics, High-spectral resolution, Astrophysics - Earth and Planetary Astrophysics
Abstract: New generation exoplanet imagers on large ground-based telescopes are highly optimised for the detection of young giant exoplanets in the near-infrared, but they are intrinsically limited for their characterisation by the low spectral resolution of their integral field spectrographs ($R, Submitted to SPIE Astronomical Telescopes + Instrumentation 2022, Adaptive Optics Systems VIII, Paper 12185-27
Published: 2022

5. SAXO+, a second-stage adaptive optics for SPHERE on VLT: optical and mechanical design concept

Author: Eric Stadler, Emiliano Diolaiti, Laura Schreiber, Fausto Cortecchia, Matteo Lombini, Magali Loupias, Yves Magnard, Adriano De Rosa, Giuseppe Malaguti, Didier Maurel, Gianluca Morgante, Patrick Rabou, Sylvain Rochat, Filomena Schiavone, Luca Terenzi, Fabrice Vidal, Faustine Cantalloube, Éric Gendron, Raffaele Gratton, Julien Milli, David Mouillet, Gaël Chauvin, François Wildi, Jean-Luc Beuzit, and Anthony Boccaletti
Published: 2022

6. Complete Transurethral Resection before Radical Cystectomy May Improve Oncological Outcomes

Author: Luc Beuzit, Gregory Verhoest, Romain Mathieu, Mathieu Roumiguié, Benoit Peyronnet, Benjamin Pradere, Karim Bensalah, Jean-Baptiste Beauval, Matthieu Thoulouzan, Xavier Gamé, Francois Guille, Alexandre Gryn, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet, V. Graffeille, Zine Eddine Khene, Quentin Alimi, and Michel Soulié
Subjects: Male, medicine.medical_specialty, Urology, medicine.medical_treatment, Cystectomy, Resection, Urethra, medicine, Clinical endpoint, Humans, Neoplasm Invasiveness, Stage (cooking), Aged, Retrospective Studies, Chemotherapy, Urinary bladder, Bladder cancer, business.industry, Carcinoma in situ, medicine.disease, Surgery, Treatment Outcome, medicine.anatomical_structure, Urinary Bladder Neoplasms, Female, business
Abstract: Objectives: The objective of this study was to assess the impact of complete transurethral resection of bladder tumors (TURBTs) before radical cystectomy on pathological and oncological outcomes of patients with muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC. Materials and Methods: The charts of all patients who underwent radical cystectomy for bladder cancer in 2 academic departments of urology between 1996 and 2016 were retrospectively reviewed. Patients were divided into 2 groups according to the completeness of the last endoscopic resection before radical cystectomy: macroscopically complete transurethral resection (complete) or macroscopically incomplete transurethral resection (incomplete). The primary end point was the recurrence-free survival (RFS). Secondary end points included cancer-specific survival (CSS) and rates of pT0 and downstaging. Results: Out of 486 patients included for analysis, the TURBT immediately preceding radical cystectomy was considered macroscopically complete in 253 patients (52.1%) and incomplete in 233 patients (47.9%). In multivariate analysis, macroscopically complete TURBT was the strongest predictor of both pT0 disease (OR = 3.1; p = 0.02) and downstaging (OR = 7.1; p < 0.0001). After a median follow-up of 41 months, macroscopically complete TURBT was associated with better RFS (5-year RFS: 57 vs. 37%; p < 0.0001) and CSS (5-year CSS: 70.8 vs. 54.5%; p = 0.002). In multivariate analysis adjusting for multifocality, weight of endoscopic resection specimen, cT4 stage on preoperative imaging, interval between endoscopic resection and radical cystectomy, neoadjuvant chemotherapy, pT stage, and associated carcinoma in situ, macroscopically complete endoscopic resection remained the main predictor of better RFS (HR = 0.4; p = 0.0003) and the only preoperative factor associated with CSS (HR = 0.5; p = 0.01). Conclusion: A macroscopically complete TURBT immediately preceding radical cystectomy may improve pathological and oncological outcomes in patients with MIBC and high-risk MIBC.
Published: 2021

7. Detecting life outside our solar system with a large high-contrast-imaging mission

Author: Ignasi Ribas, Th. Henning, P. Baudoz, M. Kasper, Pieter J. de Visser, Simon Albrecht, A.-M. Lagrange, Kevin Heng, Enric Palle, Didier Queloz, Nathan J. Mayne, Isabella Pagano, B.-O. Demory, Michiel Min, Olivier Guyon, R. van Boekel, Manuel López-Puertas, Ignas Snellen, Matthew A. Kenworthy, Guillem Anglada-Escudé, Daphne Stam, Julien Milli, Nikku Madhusudhan, Timothy M. Lenton, Garreth Ruane, John Lee Grenfell, Willy Benz, Christopher C. Stark, Valentina D'Orazi, Silvano Desidera, Mamadou N'Diaye, David Mouillet, E. J. W. de Mooij, Mark Claire, Christoph U. Keller, R. G. Gratton, Franck Selsis, A. L. Maire, Elsa Huby, Giampaolo Piotto, Alessandro Sozzetti, Jean-Luc Beuzit, Michaël Gillon, Anthony Boccaletti, Jayne Birkby, Matteo Brogi, Yamila Miguel, Arthur Vigan, Frans Snik, Beth Biller, B. S. Gaudi, Giuseppina Micela, Christiane Helling, Isabelle Baraffe, Oliver Krause, J. de Boer, Laura Kreidberg, Heike Rauer, Jean-Michel Desert, Markus Janson, Riccardo Claudi, Victoria S. Meadows, Ralf Launhardt, L. Carone, Lars A. Buchhave, Sasha Hinkley, Bertrand Mennesson, Leiden Observatory [Leiden], Universiteit Leiden, Sterrewacht Leiden, Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, Université Paris sciences et lettres (PSL), Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, Universiteit Leiden [Leiden], École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Universität Bern [Bern], Institut de Planétologie et d'Astrophysique de Grenoble (IPAG ), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Low Energy Astrophysics (API, FNWI), University of St Andrews. School of Earth & Environmental Sciences, University of St Andrews. St Andrews Centre for Exoplanet Science, University of St Andrews. St Andrews Isotope Geochemistry, University of St Andrews. School of Physics and Astronomy, European Commission, European Research Council, Science and Technology Facilities Council (UK), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, Agenzia Spaziale Italiana, Istituto Nazionale di Astrofisica, Netherlands Organization for Scientific Research, Knut and Alice Wallenberg Foundation, Snellen, IAG [0000-0003-1624-3667], and Apollo - University of Cambridge Repository
Subjects: Solar System, life, Computer science, 01 natural sciences, 010309 optics, White paper, Spitzer Space Telescope, Planet, 0103 physical sciences, Agency (sociology), QB Astronomy, 010303 astronomy & astrophysics, QC, QB, [PHYS]Physics [physics], 520 Astronomy, imaging, Astronomy and Astrophysics, High contrast imaging, 3rd-DAS, 620 Engineering, QC Physics, mission, Space and Planetary Science, 5101 Astronomical Sciences, [SDU]Sciences of the Universe [physics], Extraterrestrial life, Systems engineering, Circumstellar habitable zone, 51 Physical Sciences
Abstract: Snellen, I.A.G. et al., In this White Paper, which was submitted in response to the European Space Agency (ESA) Voyage 2050 Call, we recommend the ESA plays a proactive role in developing a global collaborative effort to construct a large high-contrast imaging space telescope, e.g. as currently under study by NASA. Such a mission will be needed to characterize a sizable sample of temperate Earth-like planets in the habitable zones of nearby Sun-like stars and to search for extraterrestrial biological activity. We provide an overview of relevant European expertise, and advocate ESA to start a technology development program towards detecting life outside the Solar System., I.S. acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 694513. A.L.M. acknowledges the financial support of the F.R.S.-FNRS through a postdoctoral researcher grant. MB acknowledges support from the UK Science and Technology Facilities Council (STFC) research grant ST/S000631/1. I.R. acknowledges support from the Spanish Ministry of Science and Innovation and the European Regional Development Fund through grant PGC2018-098153-B-C33, as well as the support of the Generalitat de Catalunya/CERCA programme. E.P. acknowledges support from the Spanish Ministry of Science through grant PGC2018-098153-B-C31. J.M.D. acknowledges funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement no. 679633; Exo-Atmos) Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. We acknowledge financial support from the ASI-INAF agreement n.2018-16-HH.0 We acknowledge financial support from Spanish MCIU SEV-2017-0709 and PID2019-110689RB-I00 awards. We acknowledge financial support from the ASI-INAF agreement n.2018-16-HH.0 AV acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 757561). KH acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 771620). NJM acknowledges funding from the Leverhulme Trust, and a Science and Technology Facilities Council Consolidated Grant (ST/R000395/1). PdV acknowledges funding from the Netherlands Organisation for Scientific Research NWO (Veni Grant No. 639.041.750). IP acknowledges financial support from the ASI-INAF agreements 2019-29-HH.06-HH.0 and 2015-019-R.1-2018. FS acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 678194; FALCONER). MJ acknowledges support from the Knut and Alice Wallenberg foundation (KAW). JLB acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 805445. T.H. acknowledges support from the European Research Council under the Horizon 2020 Framework Program via the ERC Advanced Grant Origins 83 24 28. JLG acknowledges ISSI Team 464 for useful discussion.
Published: 2021

8. HD142527: Quantitative disk polarimetry with SPHERE

Author: Francois Menard, Christian Ginski, S. Hunziker, Th. Henning, H. M. Schmid, Henning Avenhaus, Gael Chauvin, David Mouillet, Kjetil Dohlen, Maud Langlois, R. G. Gratton, C. Tschudi, Julien Milli, R. G. van Holstein, Carsten Dominik, Arthur Vigan, N. Engler, Jean-Luc Beuzit, J. Ma, Anthony Boccaletti, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Low Energy Astrophysics (API, FNWI)
Subjects: Protoplanetary disks, Polarimetry, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Protoplanetary disk, 01 natural sciences, Light scattering, Photometry (optics), Scattering, Polarization, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Physics, [PHYS]Physics [physics], Earth and Planetary Astrophysics (astro-ph.EP), 010308 nuclear & particles physics, Linear polarization, Techniques: polarimetric, Astronomy and Astrophysics, individual: HD 142527, instrumentation: high angular resolution, techniques: polarimetric, protoplanetary disks, polarization, scattering [stars], Polarization (waves), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Instrumentation: high angular resolution, Degree of polarization, Astrophysics::Earth and Planetary Astrophysics, Stars: individual: HD 142527, Astrophysics - Earth and Planetary Astrophysics
Abstract: We present high-precision photometry and polarimetry for the protoplanetary disk around HD142527, with a focus on determining the light scattering parameters of the dust. We re-reduced polarimetric differential imaging data of HD142527 in the VBB (735 nm) and H-band (1625 nm) from the ZIMPOL and IRDIS subinstruments of SPHERE/VLT. With polarimetry and photometry based on reference star differential imaging, we were able to measure the linearly polarized intensity and the total intensity of the light scattered by the circumstellar disk with high precision. We used simple Monte Carlo simulations of multiple light scattering by the disk surface to derive constraints for three scattering parameters of the dust: the maximum polarization of $P_{\rm max}$, the asymmetry parameter $g$, and the single-scattering albedo $\omega$. We measure a reflected total intensity of $51.4\pm1.5$ mJy and $206\pm12$ mJy and a polarized intensity of $11.3\pm0.3$ mJy and $55.1\pm3.3$ mJy in the VBB and H-band, respectively. We also find in the visual range a degree of polarization that varies between $28\%$ on the far side of the disk and $17\%$ on the near side. The disk shows a red color for the scattered light intensity and the polarized intensity, which are about twice as high in the near-infrared when compared to the visual. We determine with model calculations the scattering properties of the dust particles and find evidence for strong forward scattering ($g\approx 0.5-0.75$), relatively low single-scattering albedo ($\omega \approx 0.2-0.5$), and high maximum polarization ($P_{\rm max} \approx 0.5-0.75$) at the surface on the far side of the disk for both observed wavelengths. The optical parameters indicate the presence of large aggregate dust particles, which are necessary to explain the high maximum polarization, the strong forward-scattering nature of the dust, and the observed red disk color., Comment: 20 pages, 14 figures
Published: 2021
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9. The SPHERE infrared survey for exoplanets (SHINE). I. Sample definition and target characterization

Author: E. L. Rickman, Julien Charton, Stéphane Udry, A. Roux, S. Rochat, Alice Zurlo, O. Möller-Nilsson, Riccardo Claudi, D. Fantinel, A. Pavlov, E. Covino, Christian Soenke, M. Kasper, Valentina D'Orazi, Anne-Lise Maire, Joshua E. Schlieder, J. Pragt, Enrico Cascone, Markus Janson, Mariangela Bonavita, T. Kopytova, C. Petit, P. Martinez, Mickael Bonnefoy, A. Deboulbe, Joany Andreina Manjarres Ramos, Franz-Josef Hambsch, L. Weber, Francois Menard, Thibaut Moulin, A. Bazzon, Yves Magnard, Norbert Hubin, F. Rigal, Thiam-Guan Tan, Eric Stadler, J.-F. Sauvage, T. O. B. Schmidt, Emmanuel Hugot, L. Gluck, Th. Henning, S. Benatti, Michael Meyer, Raphaël Galicher, Anne-Marie Lagrange, M. Feldt, M. Carle, Carsten Dominik, G. Rousset, Matthias Samland, Tristan Buey, Janis Hagelberg, H. M. Schmid, Philippe Feautrier, D. Le Mignant, Arnaud Sevin, H. LeCoroller, Pierre Baudoz, J. Antichi, Arthur Vigan, Wolfgang Brandner, Massimo Turatto, Gael Chauvin, Alain Origne, R. Ligi, P. Gigan, Bernardo Salasnich, C. Lazzoni, V. De Caprio, M. Jaquet, D. Gisler, Pascal Puget, Philippe Delorme, D. Perret, T. Fusco, Dino Mesa, E. Sissa, Francois Wildi, Silvano Desidera, D. Maurel, F. Madec, Joseph C. Carson, J. M. Alcalá, E. Rigliaco, S. Messina, J. Baudrand, Anne Costille, R. G. Gratton, M. Millward, André Müller, Beth Biller, Enrico Giro, Andrea Baruffolo, Faustine Cantalloube, Jean-Luc Beuzit, Ronald Roelfsema, Marcel Carbillet, Eric Lagadec, Kjetil Dohlen, R. Asensio-Torres, Anthony Cheetham, P. Rabou, M. Llored, Maud Langlois, P. Blanchard, Anthony Boccaletti, C. Fontanive, Marcos Suarez, L. Abe, and Low Energy Astrophysics (API, FNWI)
Subjects: PRE-MAIN SEQUENCE [STARS], HIGH CONTRAST IMAGING, STATISTICAL CONSTRAINTS, PLANET DETECTION, FOS: Physical sciences, Sample (statistics), Context (language use), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, ROTATION [STARS], ROTATION PERIOD, 01 natural sciences, 7. Clean energy, FUNDAMENTAL PARAMETERS [STARS], Planet, 0103 physical sciences, GENERAL [PLANETS AND SATELLITES], DETECTION LIMITS, Astrophysics::Solar and Stellar Astrophysics, KINEMATICS AND DYNAMICS [STARS], ACTIVITY [STARS], 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics::Galaxy Astrophysics, Physics, Earth and Planetary Astrophysics (astro-ph.EP), 010308 nuclear & particles physics, Astronomy and Astrophysics, TARGET CHARACTERIZATION, Light curve, Exoplanet, Characterization (materials science), SPHERES, Stars, Astrophysics - Solar and Stellar Astrophysics, 13. Climate action, Space and Planetary Science, ORIGINAL SAMPLE, STATISTICAL SAMPLES, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Rotation (mathematics), SURVEYS, STARS, EXTRASOLAR PLANETS, Astrophysics - Earth and Planetary Astrophysics
Abstract: Large surveys with new-generation high-contrast imaging instruments are needed to derive the frequency and properties of exoplanet populations with separations from ~5 to 300 au. A careful assessment of the stellar properties is crucial for a proper understanding of when, where, and how frequently planets form, and how they evolve. The sensitivity of detection limits to stellar age makes this a key parameter for direct imaging surveys. Aims. We describe the SpHere INfrared survey for Exoplanets (SHINE), the largest direct imaging planet-search campaign initiated at the VLT in 2015 in the context of the SPHERE Guaranteed Time Observations of the SPHERE consortium. In this first paper we present the selection and the properties of the complete sample of stars surveyed with SHINE, focusing on the targets observed during the first phase of the survey (from February 2015 to February 2017). This early sample composed of 150 stars is used to perform a preliminary statistical analysis of the SHINE data, deferred to two companion papers presenting the survey performance, main discoveries, and the preliminary statistical constraints set by SHINE. Methods. Based on a large database collecting the stellar properties of all young nearby stars in the solar vicinity (including kinematics, membership to moving groups, isochrones, lithium abundance, rotation, and activity), we selected the original sample of 800 stars that were ranked in order of priority according to their sensitivity for planet detection in direct imaging with SPHERE. The properties of the stars that are part of the early statistical sample wererevisited, including for instance measurements from the Gaia Data Release 2. Rotation periods were derived for the vast majority of the late-type objects exploiting TESS light curves and dedicated photometric observations. Results. The properties of individual targets and of the sample as a whole are presented. © ESO 2021. SPHERE is an instrument designed and built by a consortium consisting of IPAG (Grenoble, France), MPIA (Heidelberg, Germany), LAM (Marseille, France), LESIA (Paris, France), Laboratoire Lagrange (Nice, France), INAF – Osservatorio di Padova (Italy), Observatoire de Genève (Switzerland), ETH Zürich (Switzerland), NOVA (Netherlands), ONERA (France) and ASTRON (Netherlands) in collaboration with ESO. SPHERE was funded by ESO, with additional contributions from CNRS (France), MPIA (Germany), INAF (Italy), FINES (Switzerland) and NOVA (Netherlands). SPHERE also received funding from the European Commission Sixth and Seventh Framework Programmes as part of the Optical Infrared Coordination Network for Astronomy (OPTICON) under grant number RII3-Ct-2004-001566 for FP6 (2004–2008), grant number 226 604 for FP7 (2009–2012) and grant number 312430 for FP7 (2013–2016). This research has made use of the SIMBAD database and Vizier services, operated at CDS, Strasbourg, France and of the Washington Double Star Catalog maintained at the US Naval Observatory. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. This paper includes data collected with the TESS mission, obtained from the MAST data archive at the Space Telescope Science Institute (STScI). Funding for the TESS mission is provided by the NASA Explorer Program. STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5–26555. This paper has made use of data products available in ESO archive. Program ID: 60.A-9036(A); 072.C-0488(E) (PI Mayor), 074.C-0364(A) (PI Robichon), 074.C-0037(A) (PI Gunther), 075.C-0202(A) (PI Gunther), 075.C-0689(A) (PI Galland), 076.C-0010(A) (PI Gunther), 077.C-0012(A) (PI Gunther), 077.C-0295(D) (PI Galland), 078.D-0245(C) (PI Dall), 079.C-0046(A) (PI Gunther), 080.D-0151(A) (PI Hatzes), 080.C-0712(A) (PI Desort), 180.C-0886(A) (PI Bonfils), 082.C-0718(B) (PI Bonfils), 082.C-0427(A) (PI Doellinger), 082.C-0390(A) (PI Weise), 183.C-0437(A) (PI Bonfils), 083.C-0794(A) (PI Chauvin), 084.C-1039(A) (PI Chauvin), 184.C-0815(B) (PI Desort), 089.C-0732(A) (PI Lo Curto), 191.C-0873(D) (PI Bonfils), 192.C-0224(A) (PI Lagrange), 097.C-0864(B) (PI Lannier), 098.C-0739(A) (PI Lagrange), 099.C-0205(A) (PI Lagrange), 099.C-0458(A) (PI Lo Curto), 1101.C-0557(A) (PI Lagrange). We have used data from the WASP public archive in this research. The WASP consortium comprises of the University of Cambridge, Keele University, University of Leicester, The Open University, The Queen’s University Belfast, St. Andrews University and the Isaac Newton Group. Funding for WASP comes from the consortium universities and from the UK’s Science and Technology Facilities Council. Based on data retrieved from the SOPHIE archive at Observatoire de Haute-Provence (OHP), available at http://atlas.obs-hp.fr/sophie/. We thank the anonymous referee for useful comments. S.D., V.D., D.M. and R.G. acknowledge the support by INAF/Frontiera through the “Progetti Premiali” funding scheme of the Italian Ministry of Education, University, and Research, the PRIN-INAF 2019 “Planetary systems at young ages” (PLATEA) and the ASI-INAF agreement n.2018-16-HH.0. AV acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 757561). A.M.L. acknowledges funding from Agence Nationale de la Recherche (France) under contract number ANR-14-CE33-0018. J.C. was supported by SC Space Grant and Fulbright Colombia. M.B. acknowledges funding by the UK Science and Technology Facilities Council (STFC) grant no. ST/M001229.
Published: 2021

10. The ORP on-sky community access program for adaptive optics instrumentation development

Author: Tim Morris, D. Bonaccini Calia, Simone Esposito, Carlos Correia, I. Montilla, Maritza Reyes, James Osborn, T. Fusco, Caroline Kulcsár, Lisa Bardou, Eric Gendron, Lazar Staykov, Gérard Rousset, Jean-Luc Beuzit, Benoit Neichel, Nazim Ali Bharmal, Paulo J. V. Garcia, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Durham University, Instituto de Astrofisica de Canarias (IAC), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Aix Marseille Université (AMU), INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Universidade do Porto, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Universidade do Porto = University of Porto
Subjects: Upstream (petroleum industry), ADAPTIVE OPTICS, INSTRUMENT DEVELOPMENT, [PHYS]Physics [physics], Computer science, Process (engineering), business.industry, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Visitor pattern, Plan (drawing), ON-SKY TESTING, [PHYS.ASTR.SR]Physics [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Test (assessment), law.invention, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Telescope, [SPI]Engineering Sciences [physics], Work (electrical), law, Instrumentation (computer programming), Telecommunications, business, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; On-sky testing of new instrumentation concepts is required before they can be incorporated within facility-class instrumentation with certainty that they will work as expected within a real telescope environment. Increasingly, many of these concepts are not designed to work in seeing-limited conditions and require an upstream adaptive optics system for testing. Access to on-sky AO systems to test such systems is currently limited to a few research groups and observatories worldwide, leaving many concepts unable to be tested. A pilot program funded through the H2020 OPTICON program offering up to 15 nights of on-sky time at the CANARY Adaptive Optics demonstrator is currently running but this ends in 2021. Pre-run and on-sky support is provided to visitor experiments by the CANARY team. We have supported 6 experiments over this period, and plan one more run in early 2021. We have recently been awarded for funding through the H2020 OPTICON-RADIO PILOT call to continue and extend this program up until 2024, offering access to CANARY at the 4.2m William Herschel Telescope and 3 additional instruments and telescopes suitable for instrumentation development. Time on these facilities will be open to researchers from across the European research community and time will be awarded by answering a call for proposals that will be assessed by an independent panel of instrumentation experts. Unlike standard observing proposals we plan to award time up to 2 years in advance to allow time for the visitor instrument to be delivered. We hope to announce the first call in mid-2021. Here we describe the facilities offered, the support available for on-sky testing and detail the eligibility and application process.
Published: 2020

11. Retraction

Author: Kevin Wagner, Dániel Apai, Markus Kasper, Kaitlin Kratter, Melissa McClure, Massimo Robberto, and Jean-Luc Beuzit
Subjects: Multidisciplinary
Published: 2022

12. Percutaneous Ablation Versus Surgical Resection for Local Recurrence Following Partial Nephrectomy for Renal Cell Cancer: A Propensity Score Analysis (REPART Study-UroCCR 71)

Author: Karim Bensalah, Pierre Bigot, Nicolas Doumerc, Idir Ouzaid, Zine-Eddine Khene, Luc Beuzit, Jonathan Olivier, Cosmina Nedelcu, Jean-Christophe Bernhard, Marie Brassier, V. Dang, François Xavier Nouhaud, and Nicolas Grenier
Subjects: medicine.medical_specialty, Percutaneous, Urology, medicine.medical_treatment, 030232 urology & nephrology, Renal function, Lower risk, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, medicine, Humans, Propensity Score, Carcinoma, Renal Cell, Retrospective Studies, Kidney, business.industry, Hazard ratio, medicine.disease, Kidney Neoplasms, medicine.anatomical_structure, Treatment Outcome, 030220 oncology & carcinogenesis, Propensity score matching, Catheter Ablation, Neoplasm Recurrence, Local, business
Abstract: Background Data comparing percutaneous ablation (PCA) and surgical resection (SR) for an isolated local recurrence (LR) following partial nephrectomy (PN) for renal cell carcinoma (RCC) are lacking. Objective To examine the outcomes between PCA and SR for an isolated LR following PN for RCC. Design, setting, and participants Patients who underwent PN for RCC and developed an LR between 2013 and 2019 were included. An LR was defined as the appearance of a mass in contact with the resection bed or the development of a tumor in the same region of the homolateral kidney as the original site. Intervention PCA or SR. Outcome measurements and statistical analysis To achieve balance in baseline characteristics, we used inverse probability of treatment weighting (IPTW) based on propensity to receive treatment. Oncological outcomes, complications, and renal function were evaluated between groups using logistic, linear, and Cox proportional hazard regression models. Results and limitations A total of 81 patients with an isolated LR were included (PCA: 42; SR: 39). The median follow-up was 23 mo. After adjustment, excellent balance was achieved for the majority of propensity score variables. In IPTW analysis, PCA was associated with a lower risk of postoperative complications (odds ratio = 0.22; p = 0.006) and a smaller change in eGFR (beta = −16.18; p = 0.001). There were no significant differences in the risk of disease recurrence (hazard ratio [HR] = 0.72; p = 0.61), new LR (HR = 1.51; p = 0.59), and distant metastasis (HR = 0.19; p = 0.09). Limitations include the sample size and unmeasured confounding factors. Conclusions Our results suggest that PCA provides comparable oncological outcomes to repeat surgery with fewer complications and better renal function preservation for the management of an LR after PN. Patient summary This report shows that percutaneous ablation can be used for treating a local recurrence of renal cell carcinoma after partial nephrectomy, without significantly compromising cancer control.
Published: 2020

13. Orbital and spectral characterization of the benchmark T-type brown dwarf HD 19467B

Author: N. Frankel, Ronald Roelfsema, Anthony Cheetham, Jean-Loup Baudino, P. Mollière, Janis Hagelberg, Thomas Henning, Alain Roux, Michael R. Meyer, Joany Andreina Manjarres Ramos, Benjamin Charnay, Stéphane Udry, R. Galicher, C. Lazzoni, T. O. B. Schmidt, Sergio Messina, Beth Biller, Alice Zurlo, Roxanne Ligi, Mickael Bonnefoy, C. Perrot, Raffaele Gratton, Damien Ségransan, Gael Chauvin, Philippe Delorme, T. Bhowmik, A-M. Lagrange, Silvano Desidera, Dino Mesa, Anne-Lise Maire, Anthony Boccaletti, Wolfgang Brandner, E. L. Rickman, Trifon Trifonov, Maud Langlois, J. Pragt, Karan Molaverdikhani, Baptiste Lavie, Valentina D'Orazi, L. Gluck, Faustine Cantalloube, Jean-Luc Beuzit, André Müller, Arthur Vigan, J.-F. Sauvage, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: 010504 meteorology & atmospheric sciences, planets and satellites: dynamical evolution and stability, FOS: Physical sciences, Library science, techniques: image processing, Astrophysics, 01 natural sciences, stars: individual: HD 19467, 0103 physical sciences, media_common.cataloged_instance, European union, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, media_common, Earth and Planetary Astrophysics (astro-ph.EP), Physics, [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], European research, techniques: high angular resolution, Astronomy and Astrophysics, methods: data analysis, Astrophysics - Solar and Stellar Astrophysics, 13. Climate action, Space and Planetary Science, Astrophysics - Instrumentation and Methods for Astrophysics, brown dwarfs, Astrophysics - Earth and Planetary Astrophysics
Abstract: Context. Detecting and characterizing substellar companions for which the luminosity, mass, and age can be determined independently is of utter importance to test and calibrate the evolutionary models due to uncertainties in their formation mechanisms. HD 19467 is a bright and nearby star hosting a cool brown dwarf companion detected with RV and imaging, making it a valuable object for such studies. Aims. We aim to further characterize the orbital, spectral, and physical properties of the HD 19467 system. Methods. We present new high-contrast imaging data with the SPHERE and NaCo instruments. We also analyze archival data from HARPS, NaCo, HIRES, UVES, and ASAS. We also use proper motion data of the star from Hipparcos and Gaia. Results. We refine the properties of the host star and derive an age of 8.0$^{+2.0}_{-1.0}$ Gyr based on isochrones, gyrochronology, and chemical and kinematic arguments. This estimate is slightly younger than previous estimates of ~9-11 Gyr. No orbital curvature is seen in the current imaging, RV, and astrometric data. From a joint fit of the data, we refine the orbital parameters for HD 19467B: period 398$^{+95}_{-93}$ yr, inclination 129.8$^{+8.1}_{-5.1}$ deg, eccentricity 0.56$\pm$0.09, longitude of the ascending node 134.8$\pm$4.5 deg, and argument of the periastron 64.2$^{+5.5}_{-6.3}$ deg. We assess a dynamical mass of 74$^{+12}_{-9}$ MJ. The fit with atmospheric models of the spectrophotometric data of HD 19467B indicates an atmosphere without clouds or with very thin clouds, an effective temperature of 1042$^{+77}_{-71}$ K, and a large surface gravity of 5.34$^{+0.08}_{-0.09}$ dex. The comparison to model predictions of the bolometric luminosity and dynamical mass of HD 19467B, assuming our system age estimate, indicates a better agreement with the Burrows et al. models; whereas the other evolutionary models used tend to underestimate its cooling rate., Accepted for publication in A&A, 25 pages, 23 figures, 9 tables. Abstract slightly abridged to match arXiv requirements. Updated after language editing
Published: 2020

14. Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial

Author: Boris Guiu, Eveline Boucher, Samuel Le Sourd, Olivier Farge, David Tougeron, Astrid Lièvre, Karim Boudjema, Yann Touchefeu, Isabelle Baumgaertner, Ahmet Ayav, Etienne Garin, Luc Beuzit, Marc Pracht, Julien Edeline, Yan Rolland, Boris Campillo-Gimenez, Jonchère, Laurent, Centre Eugène Marquis (CRLCC), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d’Anatomie Pathologique [CHU Beaujon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Service d'Oncologie médicale [CHU Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was partially funded by BTG Corporation and the Ligue Contre le Cancer., Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor [Créteil]
Subjects: Male, Cancer Research, medicine.medical_specialty, Phases of clinical research, Gastroenterology, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, 030212 general & internal medicine, Progression-free survival, Prospective cohort study, Aged, [SDV.IB] Life Sciences [q-bio]/Bioengineering, business.industry, Combination chemotherapy, Middle Aged, Chemotherapy regimen, Gemcitabine, 3. Good health, Bile Ducts, Intrahepatic, Treatment Outcome, Bile Duct Neoplasms, Oncology, Response Evaluation Criteria in Solid Tumors, 030220 oncology & carcinogenesis, Concomitant, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Neoplasm Recurrence, Local, business, medicine.drug
Abstract: International audience; Importance - Patients with unresectable intrahepatic cholangiocarcinoma (ICC) have a poor prognosis. Selective internal radiotherapy (SIRT) is a promising treatment option for hepatic tumors, but no prospective studies of combination SIRT with chemotherapy have been published to our knowledge. Objective - To determine the response rate after SIRT combined with chemotherapy in patients with unresectable ICC. Design, setting, and participants - This phase 2 clinical trial, the Yttrium-90 Microspheres in Cholangiocarcinoma (MISPHEC) trial, included patients with unresectable ICC who have never received chemotherapy or intra-arterial therapy and were treated at 7 centers which had experience with SIRT between November 12, 2013, and June 21, 2016. Statistical analysis was performed from March 31, 2017, to June 17, 2019. Interventions - Concomitant first-line chemotherapy with cisplatin, 25 mg/m2, and gemcitabine, 1000 mg/m2 (gemcitabine reduced to 300 mg/m2 for the cycles just before and after SIRT), on days 1 and 8 of a 21-day cycle for 8 cycles. Selective internal radiotherapy was administered during cycle 1 (1 hemiliver disease) or cycles 1 and 3 (disease involving both hemilivers) using glass Y90 microspheres. Main outcomes and measures - Response rate at 3 months according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Secondary end points were toxic effects, progression-free survival, overall survival, disease control rate, and response rate according to Choi criteria. Results - Of 41 patients included in the study, 26 (63%) were male, with a mean (SD) age of 64.0 (10.7) years. Response rate according to RECIST was 39% (90% CI, 26%-53%) at 3 months according to local review and was confirmed at 41% as best response by central review; disease control rate was 98%. According to Choi criteria, the response rate was 93%. After a median follow-up of 36 months (95% CI, 26-52 months), median progression-free survival was 14 months (95% CI, 8-17 months), with progression-free survival rates of 55% at 12 months and 30% at 24 months. Median overall survival was 22 months (95% CI, 14-52 months), with overall survival rates of 75% at 12 months and 45% at 24 months. Of 41 patients, 29 (71%) had grades 3 to 4 toxic effects; 9 patients (22%) could be downstaged to surgical intervention, with 8 (20%) achieving R0 (microscopic-free margins) surgical resection. After a median of 46 months (95% CI, 31 months to not reached) after surgery, median relapse-free survival was not reached among patients who underwent resection. Conclusions and relevance - Combination chemotherapy and SIRT had antitumor activity as first-line treatment of unresectable ICC, and a significant proportion of patients were downstaged to surgical intervention. A phase 3 trial is ongoing.
Published: 2020

15. K-Stacker: an algorithm to hack the orbital parameters of planets hidden in high-contrast imaging: First applications to VLT/SPHERE multi-epoch observations

Author: Jean-Luc Beuzit, Arthur Vigan, Markus Feldt, Kjetil Dohlen, H. Le Coroller, E. Sissa, A. L. Maire, Pierre Vernazza, A. Schneeberger, Anthony Cheetham, S. Rochat, Michael R. Meyer, Thierry Fusco, Mariangela Bonavita, D. Estevez, D. Le Mignant, François Ménard, Joany Andreina Manjarres Ramos, Matthias Samland, Mathias Nowak, Mickael Bonnefoy, J. C. Lambert, Alice Zurlo, Valentina D'Orazi, Dino Mesa, Philippe Delorme, A. Boccaletti, Hervé Beust, R. Galicher, Roxanne Ligi, Gael Chauvin, A-M. Lagrange, Markus Janson, T. Fenouillet, Raffaele Gratton, David Mouillet, L. Arnold, M. Devinat, Silvano Desidera, Maud Langlois, J. Bec-Canet, C. Desgrange, Jean-François Sauvage, Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), European Southern Observatory (ESO), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Department of Astronomy, Stockholm University, Department of Biochemistry and Molecular Biology, Mayo Clinic, DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, University of Copenhagen = Københavns Universitet (KU), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), and University of Copenhagen = Københavns Universitet (UCPH)
Subjects: [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], planets and satellites: dynamical evolution and stability, [PHYS.ASTR.EP]Physics [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, Context (language use), Astrophysics, instrumentation: adaptive optics, 01 natural sciences, stars: individual: HD 95086, 03 medical and health sciences, Planet, instrumentation: high angular resolution, 0103 physical sciences, Gemini Planet Imager, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Solar and Stellar Astrophysics (astro-ph.SR), 030304 developmental biology, Orbital elements, Physics, Earth and Planetary Astrophysics (astro-ph.EP), 0303 health sciences, stars: individual: β Pictoris, Astronomy and Astrophysics, Astrometry, [PHYS.ASTR.SR]Physics [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], methods: data analysis, Exoplanet, Radial velocity, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Orbital motion, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Algorithm, Astrophysics - Earth and Planetary Astrophysics
Abstract: Recent high-contrast imaging surveys, looking for planets in young, nearby systems showed evidence of a small number of giant planets at relatively large separation beyond typically 20 au where those surveys are the most sensitive. Access to smaller physical separations between 5 and 20 au is the next step for future planet imagers on 10 m telescopes and ELTs in order to bridge the gap with indirect techniques (radial velocity, transit, astrometry with Gaia). In that context, we recently proposed a new algorithm, Keplerian-Stacker, combining multiple observations acquired at different epochs and taking into account the orbital motion of a potential planet present in the images to boost the ultimate detection limit. We showed that this algorithm is able to find planets in time series of simulated images of SPHERE even when a planet remains undetected at one epoch. Here, we validate the K-Stacker algorithm performances on real SPHERE datasets, to demonstrate its resilience to instrumental speckles and the gain offered in terms of true detection. This will motivate future dedicated multi-epoch observation campaigns in high-contrast imaging to search for planets in emitted and reflected light. Results. We show that K-Stacker achieves high success rate when the SNR of the planet in the stacked image reaches 7. The improvement of the SNR ratio goes as the square root of the total exposure time. During the blind test and the redetection of HD 95086 b, and betaPic b, we highlight the ability of K-Stacker to find orbital solutions consistent with the ones derived by the state of the art MCMC orbital fitting techniques, confirming that in addition to the detection gain, K-Stacker offers the opportunity to characterize the most probable orbital solutions of the exoplanets recovered at low signal to noise., Comment: Astronomy & Astrophysics accepted, 13 Pages, 11 Figures
Published: 2020

16. Performance of B-mode ratio and 2D shear wave elastography for the detection and quantification of hepatic steatosis and fibrosis after liver transplantation

Author: Luc Beuzit, Bruno Turlin, Christophe Aubé, Marine Dubois, Pauline Houssel-Debry, Maxime Ronot, Magali Auger, Anita Paisant, Michel Rayar, Vanessa Brun, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Liver Cirrhosis, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Liver transplantation, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Internal medicine, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Hepatology, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Ultrasound, Gold standard (test), medicine.disease, Liver Transplantation, 3. Good health, Fatty Liver, Transplantation, Liver, 030220 oncology & carcinogenesis, Liver biopsy, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Steatosis, business
Abstract: OBJECTIVES To evaluate the diagnostic performance of B-mode ratio and shear wave elastography (SWE) for the assessment of steatosis and liver fibrosis after liver transplantation. MATERIALS AND METHODS Patients hospitalized for a systematic check-up after liver transplantation underwent the same day hepatic ultrasound with B-mode ratio and SWE, followed by liver biopsy and biological examinations. Steatosis was measured using hepatorenal sonographic index of B-mode ratio and liver stiffness using SWE. Liver biopsy, used as gold standard, graded steatosis S0(
Published: 2020

17. The SPHERE infrared survey for exoplanets (SHINE)

Author: Kjetil Dohlen, André Müller, C. Petit, A. Pavlov, Valentina D'Orazi, Alexandre Emsenhuber, Alice Zurlo, E. Sissa, Ronald Roelfsema, Norbert Hubin, Marc Jaquet, Gabriel-Dominique Marleau, Gérard Rousset, Anthony Cheetham, H. Le Coroller, Alain Roux, S. Brown Sevilla, Enrico Giro, Faustine Cantalloube, Anne Costille, Janis Hagelberg, Jean-Luc Beuzit, Thierry Fusco, P. Gigan, Julien Charton, Markus Feldt, A. Bazzon, Ruben Asensio-Torres, C. Fontanive, Zahed Wahhaj, Anne-Lise Maire, Th. Henning, M. Carle, Marcel Carbillet, J. Ramos, Matthias Samland, Alain Origne, Raffaele Gratton, Arthur Vigan, Stéphane Udry, H. M. Schmid, Pierre Baudoz, Patrice Martinez, Markus Janson, O. Möller-Nilsson, L. Weber, Marcos Suarez, Cecile Gry, Michael Meyer, Sergio Messina, N. Engler, Emmanuel Hugot, Arnaud Sevin, A. Boccaletti, Alexander J. Bohn, P. Rabou, Julien Girard, T. Moulin, Jacopo Antichi, Beth Biller, F. Rigal, David Mouillet, C. Soenke, F. Madec, Riccardo Claudi, Silvano Desidera, M. Llored, E. Cascone, Daniela Fantinel, D. Gisler, R. Galicher, J. Baudrand, T. O. B. Schmidt, J. Pragt, Mickael Bonnefoy, D. Le Mignant, Mariangela Bonavita, Philippe Delorme, Jean-François Sauvage, Francois Wildi, Duncan Forgan, C. Mordasini, L. Gluck, Denis Perret, E. L. Rickman, Carsten Dominik, C. Lazzoni, E. Lagadec, Roxanne Ligi, Andrea Baruffolo, Lyu Abe, Gael Chauvin, A-M. Lagrange, Massimo Turatto, Pascal Puget, Philippe Feautrier, Yves Magnard, Bernardo Salasnich, Maud Langlois, V. De Caprio, D. Maurel, M. Kasper, Ken Rice, Dino Mesa, S. Rochat, C. Moutou, C. Perrot, Alain Delboulbé, P. Blanchard, François Ménard, Eric Stadler, Low Energy Astrophysics (API, FNWI), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Center for Space and Habitability (CSH), University of Bern, University of Edinburgh, Max Planck Institute for Radio Astronomy, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Scottish Universities Physics Alliance (SUPA), Max Planck Institute for Astronomy (MPIA), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Geneva Observatory, Université de Genève = University of Geneva (UNIGE), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Brera (OAB), Department of Biochemistry and Molecular Biology, Mayo Clinic, INAF - Osservatorio Astrofisico di Catania (OACT), Canada-France-Hawaii Telescope Corporation (CFHT), National Research Council of Canada (NRC)-Centre National de la Recherche Scientifique (CNRS)-University of Hawai'i [Honolulu] (UH), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institute for Particle Physics and Astrophysics [ETH Zürich] (IPA), Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Hippolyte Fizeau (FIZEAU), INAF - Osservatorio Astronomico di Capodimonte (OAC), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud University [Nijmegen], European Southern Observatory (ESO), Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), NASA Goddard Space Flight Center (GSFC), Institut de Recherche pour le Développement (IRD), Centre Hospitalier Henri Duffaut (Avignon), ANR-16-CE31-0013,PLANET-FORMING-DISKS,De meilleurs modèles pour de meilleures données(2016), University of Michigan [Ann Arbor], University of Michigan System, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre for Exoplanet Science, Space Sciences, Technologies and Astrophysics Research Institute (STAR), Université de Liège, Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Laboratoire Franco-Chilien d'Astronomie (LFCA), Universidad de Concepción [Chile]-Pontificia Universidad Católica de Chile (UC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Universidad de Chile, University of Geneva [Switzerland], Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Anton Pannekoek Institute for Astronomy, University of Amsterdam [Amsterdam] (UvA), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Universidad Diego Portales [Santiago] (UDP), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Radboud university [Nijmegen], DAAA, ONERA, Université Paris Saclay [Meudon], Eberhard Karls Universität Tübingen, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Lagrange, Université Côte d'Azur, Observatoire de la Côte d'Azur, CNRS., Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406 ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Gustave Eiffel, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), CHU Tenon [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Département Médico-Universitaire APPROCHES, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université (SU), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, ARCHEORIENT - Environnements et sociétés de l'Orient ancien (Archéorient), Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Centre d'étude des environnements terrestre et planétaires (CETP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidad de Chile = University of Chile [Santiago] (UCHILE)-Pontificia Universidad Católica de Chile (UC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Universidad de Concepción - University of Concepcion [Chile], Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: astro-ph.SR, astro-ph.GA, Brown dwarf, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Stellar classification, 01 natural sciences, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, planets and satellites: formation, 10. No inequality, infrared: planetary systems, 010303 astronomy & astrophysics, planetary systems, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics::Galaxy Astrophysics, Earth and Planetary Astrophysics (astro-ph.EP), Physics, Very Large Telescope, methods: statistical, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, techniques: high angular resolution, Astronomy and Astrophysics, Planetary system, Astrophysics - Astrophysics of Galaxies, Exoplanet, Accretion (astrophysics), Stars, Astrophysics - Solar and Stellar Astrophysics, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), astro-ph.EP, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Earth and Planetary Astrophysics
Abstract: The SHINE project is a 500-star survey performed with SPHERE on the VLT for the purpose of directly detecting new substellar companions and understanding their formation and early evolution. Here we present an initial statistical analysis for a subsample of 150 stars that are representative of the full SHINE sample. Our goal is to constrain the frequency of substellar companions with masses between 1 and 75 MJup and semimajor axes between 5 and 300 au. We adopt detection limits as a function of angular separation from the survey data for all stars converted into mass and projected orbital separation using the BEX-COND-hot evolutionary tracks and known distance to each system. Based on the results obtained for each star and on the 13 detections in the sample, we use a MCMC tool to compare our observations to two different types of models. The first is a parametric model based on observational constraints, and the second type are numerical models that combine advanced core accretion and gravitational instability planet population synthesis. Using the parametric model, we show that the frequencies of systems with at least one substellar companion are $23.0_{-9.7}^{+13.5}\%$, $5.8_{-2.8}^{+4.7}\%$, and $12.6_{-7.1}^{+12.9}\%$ for BA, FGK, and M stars, respectively. We also demonstrate that a planet-like formation pathway probably dominates the mass range from 1-75 MJup for companions around BA stars, while for M dwarfs, brown dwarf binaries dominate detections. In contrast, a combination of binary star-like and planet-like formation is required to best fit the observations for FGK stars. Using our population model and restricting our sample to FGK stars, we derive a frequency of $5.7_{-2.8}^{+3.8}\%$, consistent with predictions from the parametric model. More generally, the frequency values that we derive are in excellent agreement with values obtained in previous studies., Comment: 24 pages, 14 figures, 3 tables. Accepted for publication in A&A
Published: 2020

18. The search for disks or planetary objects around directly imaged companions: A candidate around DH Tau B

Author: E. L. Rickman, Markus Janson, Anthony Boccaletti, C. Fontanive, Matthias Samland, C. Lazzoni, S. Peretti, Francois Wildi, Mickael Bonnefoy, M. Houllé, T. Schmidt, C. Perrot, André Müller, Graeme Salter, Miriam Keppler, Raphaël Galicher, E. Sissa, Janis Hagelberg, Anne-Lise Maire, Th. Henning, Silvano Desidera, Arthur Vigan, Alice Zurlo, Steve Ertel, Beth Biller, Ken Rice, J. Lannier, Maud Langlois, R. Asensio-Torres, Wolfgang Brandner, Gael Chauvin, Faustine Cantalloube, R. G. Gratton, Esther Buenzli, Jean-Luc Beuzit, M. Cudel, Anthony Cheetham, David Mouillet, M. Kasper, Philippe Delorme, Dino Mesa, Anne-Marie Lagrange, J. L. Baudino, Mariangela Bonavita, Michael Meyer, M. Feldt, Eckhart Spalding, H. LeCoroller, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: astro-ph.SR, 010504 meteorology & atmospheric sciences, 530 Physics, Library science, FOS: Physical sciences, Astrophysics, 01 natural sciences, 0103 physical sciences, Coordination network, Astrophysics::Solar and Stellar Astrophysics, European commission, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), ComputingMilieux_MISCELLANEOUS, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Physics, [PHYS]Physics [physics], Earth and Planetary Astrophysics (astro-ph.EP), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 520 Astronomy, European research, Astronomy and Astrophysics, 500 Science, Methods observational, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, astro-ph.EP, Christian ministry, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, astro-ph.IM
Abstract: In recent decades, thousands of substellar companions have been discovered with both indirect and direct methods of detection. In this paper, we focus our attention on substellar companions detected with the direct imaging technique, with the primary goal of investigating their close surroundings and looking for additional companions and satellites, as well as disks and rings. Any such discovery would shed light on many unresolved questions, particularly with regard to their possible formation mechanisms. To reveal bound features of directly imaged companions we need to suppress the contribution from the source itself. Therefore, we developed a method based on the negative fake companion (NEGFC) technique that first estimates the position in the field of view (FoV) and the flux of the imaged companion, then subtracts a rescaled model point spread function (PSF) from the imaged companion. Next it performs techniques, such as angular differential imaging (ADI), to further remove quasi-static patterns of the star. We applied the method to the sample of substellar objects observed with SPHERE during the SHINE GTO survey. Among the 27 planets and brown dwarfs we analyzed, we detected a possible point source close to DH Tau B. This candidate companion was detected in four different SPHERE observations, with an estimated mass of $\sim 1$ M\textsubscript{Jup}, and a mass ratio with respect to the brown dwarf of $1/10$. This binary system, if confirmed, would be the first of its kind, opening up interesting questions for the formation mechanism, evolution, and frequency of such pairs. In order to address the latter, the residuals and contrasts reached for 25 companions in the sample of substellar objects observed with SPHERE were derived. If the DH Tau Bb companion is real, the binary fraction obtained is $\sim 7\%$, which is in good agreement with the results obtained for field brown dwarfs., Comment: 19 pages, 17 figures
Published: 2020
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19. Yttrium-90 glass microspheres radioembolization (RE) for biliary tract cancer: a large single-center experience

Author: Vincent Manceau, Luc Beuzit, Yan Rolland, Marc Pracht, Julien Edeline, Xavier Palard, Astrid Lièvre, Fanny Le Du, Thomas Uguen, Héloïse Bourien, Karim Boudjema, Samuel Le Sourd, Etienne Garin, CRLCC Eugène Marquis (CRLCC), Département de Radiologie [CHU de Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), ANR-11-LABX-0018-01, Agence Nationale de la Recherche (FR), ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011), Université de Rennes (UR), and Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, [SDV.CAN]Life Sciences [q-bio]/Cancer, Single Center, Gastroenterology, 030218 nuclear medicine & medical imaging, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Dosimetry, Internal medicine, medicine, Humans, Yttrium Radioisotopes, Radiology, Nuclear Medicine and imaging, Radioembolization, 90Y, Retrospective Studies, Intrahepatic cholangiocarcinoma, Chemotherapy, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, General Medicine, Embolization, Therapeutic, Survival Analysis, Microspheres, Confidence interval, 3. Good health, Clinical trial, Biliary Tract Neoplasms, Biliary tract, 030220 oncology & carcinogenesis, Concomitant, Cohort, Orthopedic surgery, Biliary tract cancer, Female, Glass, business
Abstract: International audience; Purpose - Radioembolization (RE) is a promising treatment option for biliary tract cancers (BTC). We report here the largest series to date using this treatment modality. Methods - We retrospectively studied data from 64 patients treated outside prospective clinical trial at our institution. We studied baseline characteristics as potential prognostic factors. We studied dose delivered to the tumor as predictive factors of outcomes in patients not receiving concomitant chemotherapy. Results - The Progression-Free Survival and Overall Survival (OS) were 7.6 months [95% Confidence Interval (CI): 4.6-10.6] and 16.4 months [95% CI: 7.8-25.0] in the whole cohort. The factors independently associated with OS in multivariable analysis were the primary localization of ICC (HR = 0.27, 95% CI: 0.11-0.68, p = 0.005) and a PS > 0 (HR = 2.21, 95% CI: 1.11-4.38, p = 0.024). During follow-up, 12 patients (19%) underwent surgery following downstaging, with a median OS of 51.9 months. In patients not treated with concomitant chemotherapy (n = 31), OS was significantly higher in patients with a dose delivered to the tumor 260Gy or higher than in patients with a dose delivered to the tumor lower than 260Gy (median 28.2 vs 11.4 months, log-rank p = 0.019). Conclusion - Our results confirm that RE is a promising treatment modality in BTC. A high proportion of patients could be downstaged to surgery, with promising long-term survival. Dose delivered to the tumor correlated with clinical outcomes when chemotherapy was not used concomitantly.
Published: 2018

20. Optical polarised phase function of the HR 4796A dust ring

Author: R. Roelfsema, Julien Milli, Christophe Pinte, Quentin Kral, Gael Chauvin, Jean-Charles Augereau, Thibaut Moulin, Alice Zurlo, O. Moeller-Nilsson, H. M. Schmid, C. Perrot, N. Engler, François Ménard, Philippe Thébault, A. M. Lagrange, Andreas Bazzon, Jean-Luc Beuzit, Anthony Boccaletti, Johan Olofsson, D. Mouillet, Henning Avenhaus, M. Llored, Elodie Choquet, J. Pragt, Carsten Dominik, Th. Henning, European Southern Observatory (ESO), Institute for Particle Physics and Astrophysics [ETH Zürich] (IPA), Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Universidad de Valparaiso [Chile], Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Unidad Mixta Internacional Franco-Chilena de Astromia, Universidad de Chile (CNRS/INSU), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Universidad Diego Portales [Santiago] (UDP), NOVA Opticla Infrared Instrumentation group at ASTRON, Low Energy Astrophysics (API, FNWI), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Mie scattering, Polarimetry, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, Context (language use), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 0103 physical sciences, Surface roughness, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Earth and Planetary Astrophysics (astro-ph.EP), [PHYS]Physics [physics], Physics, Scattering, Astronomy and Astrophysics, Stars, Space and Planetary Science, SPHERES, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Earth and Planetary Astrophysics
Abstract: The scattering properties of the dust originating from debris discs are still poorly known. The analysis of scattered light is however a powerful remote-sensing tool to understand the physical properties of dust particles orbiting other stars. Scattered light is indeed widely used to characterise the properties of cometary dust in the solar system. We aim to measure the morphology and scattering properties of the dust from the debris ring around HR4796A in polarised optical light. We obtained high-contrast polarimetric images of HR4796A in the wavelength range 600-900nm with the SPHERE / ZIMPOL instrument on the Very Large Telescope. We measured for the first time the polarised phase function of the dust in a debris system over a wide range of scattering angles in the optical. We confirm that it is incompatible with dust particles being compact spheres under the assumption of the Mie theory, and propose alternative scenarios compatible with the observations, such as particles with irregular surface roughness or aggregate particles., 12 pages, 11 figures
Published: 2019

21. Comparison of F-18-Choline PET/CT and MRI functional parameters in prostate cancer

Author: Hervé Saint-Jalmes, Luc Beuzit, Patrick Bourguet, Solène Querellou, Giulio Gambarota, Florence Le Jeune, Pierre-Yves Salaun, Anne Devillers, Xavier Palard-Novello, Etienne Garin, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Eugène Marquis (CRLCC), Département de Radiologie [CHU de Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), CHRU Brest - Service de médecine nucléaire (CHU - BREST - Med Nucléaire), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM)
Subjects: Positron emission tomography, [SDV]Life Sciences [q-bio], Kinetic analysis, 18F-choline, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, medicine, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, ComputingMilieux_MISCELLANEOUS, PET-CT, medicine.diagnostic_test, business.industry, Multiparametric MRI, Magnetic resonance imaging, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, F-18-Choline, Nuclear medicine, business
Abstract: 18F-Choline (FCH) uptake parameters are strong indicators of aggressive disease in prostate cancer. Functional parameters derived by magnetic resonance imaging (MRI) are also correlated to aggressive disease. The aim of this work was to evaluate the relationship between metabolic parameters derived by FCH PET/CT and functional parameters derived by MRI. Fourteen patients with proven prostate cancer who underwent FCH PET/CT and multiparametric MRI were enrolled. FCH PET/CT consisted in a dual phase: early pelvic list-mode acquisition and late whole-body acquisition. FCH PET/CT and multiparametric MRI examinations were registered and tumoral volume-of-interest were drawn on the largest lesion visualized on the apparent diffusion coefficient (ADC) map and projected onto the different multiparametric MR images and FCH PET/CT images. Concerning the FCH uptake, kinetic parameters were extracted with the best model selected using the Akaike information criterion between the one- and two-tissue compartment models with an imaging-derived plasma input function. Other FCH uptake parameters (early SUVmean and late SUVmean) were extracted. Concerning functional parameters derived by MRI scan, cell density (ADC from diffusion weighting imaging) and vessel permeability (Ktrans and Ve using the Tofts pharmakinetic model from dynamic contrast-enhanced imaging) parameters were extracted. Spearman’s correlation coefficients were calculated to compare parameters. The one-tissue compartment model for kinetic analysis of PET images was selected. Concerning correlation analysis between PET parameters, K1 was highly correlated with early SUVmean (r = 0.83, p
Published: 2019

22. Hint of curvature in the orbital motion of the exoplanet 51 Eridani b using 3 years of VLT/SPHERE monitoring

Author: Riccardo Claudi, E. L. Rickman, T. Schmidt, Th. Henning, Michael Meyer, Henning Avenhaus, Wolfgang Brandner, M. Cudel, Mickael Bonnefoy, Janis Hagelberg, S. Daemgen, Mariangela Bonavita, A. Roux, C. Fontanive, A. Zurlo, Arthur Vigan, L. Rodet, Dino Mesa, L. Abe, Johan Olofsson, Hervé Beust, Gérard Rousset, Matthias Samland, Raphaël Galicher, L. Weber, Francois Menard, Faustine Cantalloube, Anthony Boccaletti, Daniel Rouan, Jean-Luc Beuzit, Markus Janson, Valentina D'Orazi, Zahed Wahhaj, Stéphane Udry, Sergio Messina, Silvano Desidera, Beth Biller, Anne-Marie Lagrange, Kjetil Dohlen, Anne-Lise Maire, Anthony Cheetham, R. G. Gratton, F. Rigal, C. Lazzoni, Joseph C. Carson, H. Le Coroller, D. Melnick, Gael Chauvin, C. Perrot, E. Sissa, Alain Origne, Maud Langlois, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut für Geowissenschaften [Potsdam], Universität Potsdam, Royal Observatory Edinburgh (ROE), University of Edinburgh, European Southern Observatory (ESO), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Stockholm University, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Université libre de Bruxelles (ULB), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institute of Astronomy [ETH Zürich], Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institute for Astronomy [Edinburgh] (IfA), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), NOVA Optical Infrared Instrumentation Group, Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Université Libre de Bruxelles [Bruxelles] (ULB), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), University of Potsdam = Universität Potsdam, College of Charleston, Observatoire de Paris, Université Paris sciences et lettres (PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université de Genève = University of Geneva (UNIGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010504 meteorology & atmospheric sciences, planets and satellites: dynamical evolution and stability, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, techniques: image processing, Astrophysics, 01 natural sciences, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, planetary systems, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Orbital elements, Physics, Earth and Planetary Astrophysics (astro-ph.EP), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Giant planet, techniques: high angular resolution, Astronomy and Astrophysics, Planetary system, Orbital period, methods: data analysis, Exoplanet, stars: individual: 51 Eridani, Orbit, Space and Planetary Science, Orbital motion, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Earth and Planetary Astrophysics
Abstract: Context. The 51 Eridani system harbors a complex architecture with its primary star forming a hierarchical system with the binary GJ 3305AB at a projected separation of 2000 au, a giant planet orbiting the primary star at 13 au, and a low-mass debris disk around the primary star with possibly a cold component and a warm component inferred from the spectral energy distribution. Aims. We aim to better constrain the orbital parameters of the known giant planet. Methods. We monitored the system over three years from 2015 to 2018 with the VLT/SPHERE exoplanet imaging instrument. Results. We measure an orbital motion for the planet of ~130 mas with a slightly decreasing separation (~10 mas) and find a hint of curvature. This potential curvature is further supported at 3$\sigma$ significance when including literature GPI astrometry corrected for calibration systematics. Fits of the SPHERE and GPI data using three complementary approaches provide broadly similar results. The data suggest an orbital period of 32$^{+17}_{-9}$ yr (i.e. 12$^{+4}_{-2}$ au in semi-major axis), an inclination of 133$^{+14}_{-7}$ deg, an eccentricity of 0.45$^{+0.10}_{-0.15}$, and an argument of periastron passage of 87$^{+34}_{-30}$ deg [mod 180 deg]. The time at periastron passage and the longitude of node exhibit bimodal distributions because we do not detect yet if the planet is accelerating or decelerating along its orbit. Given the inclinations of the planet's orbit and of the stellar rotation axis (134-144 deg), we infer alignment or misalignment within 18 deg for the star-planet spin-orbit. Further astrometric monitoring in the next 3-4 years is required to confirm at a higher significance the curvature in the planet's motion, determine if the planet is accelerating or decelerating on its orbit, and further constrain its orbital parameters and the star-planet spin-orbit., Comment: Accepted for publication in A&A. 15 pages, 12 figures, 6 tables. Updated following language editing, added epoch labels in Fig. 2, and changed color of orbital predictions in Fig. 5
Published: 2019
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23. Recovering saturated images for high dynamic kernel-phase analysis

Author: David Mary, Jean-Luc Beuzit, F. Martinache, Romain Laugier, Mamadou N'Diaye, Alban Ceau, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Point source, FOS: Physical sciences, techniques: image processing, Astrophysics, 01 natural sciences, symbols.namesake, stars: low-mass, 0103 physical sciences, Angular resolution, Point (geometry), 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, binaries: close, Pixel, 010308 nuclear & particles physics, techniques: high angular resolution, Astronomy and Astrophysics, Radial velocity, Fourier transform, Kernel (image processing), Space and Planetary Science, techniques: interferometric, Computer Science::Computer Vision and Pattern Recognition, symbols, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Algorithm, Interpolation
Abstract: Kernel-phase observables extracted from mid- to high-Strehl images are proving to be a powerful tool to probe within a few angular resolution elements of point sources. The attainable contrast is limited, however, by the dynamic range of the imaging sensors. The Fourier interpretation of images with pixels exposed beyond the saturation has so far been avoided. In cases where the image is dominated by the light of a point source, we show that we can use an interpolation to reconstruct the otherwise lost pixels with an accuracy sufficient to enable the extraction of kernel-phases from the patched image. We demonstrate the usability of our method by applying it to archive images of the Gl 494AB system taken with the Hubble Space Telescope in 1997. Using this new data point along with other resolved observations and radial velocity measurements, we produce improved constraints on the orbital parameters of the system, and consequently the masses of its components.
Published: 2019
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24. Direct imaging discovery of a Jovian exoplanet within a triple-star system

Author: Markus Kasper, Kaitlin M. Kratter, Kevin Wagner, M. K. McClure, Daniel Apai, Massimo Robberto, and Jean-Luc Beuzit
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Physics, Multidisciplinary, Triple system, FOS: Physical sciences, Astronomy, Binary number, Astrophysics, 01 natural sciences, Exoplanet, Jovian, 010309 optics, Jupiter, Orbit, Astrophysics - Solar and Stellar Astrophysics, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Spectroscopy, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics - Earth and Planetary Astrophysics
Abstract: Spying a planet in a triple-star system Thousands of extrasolar planets are now known, but only a handful have been detected in direct images. Wagner et al. used sophisticated adaptive optics to discover a planet in images of the triple-star system HD 131399 and to take a spectrum of its atmosphere (see the Perspective by Oppenheimer). The planet, about four times the mass of Jupiter, orbits around one star in the system while the other two stars move farther out. This unusual arrangement is puzzling: The planet's orbit may be stable, but it is unclear how it could have formed or migrated there. The results will be used to refine theories of planet formation. Science , this issue p. 673 ; see also p. 644
Published: 2016

25. Dynamic contrast-enhanced MRI: Study of inter-software accuracy and reproducibility using simulated and clinical data

Author: Vanessa Brun, Luc Beuzit, Hervé Saint-Jalmes, Jean-Christophe Ferré, Yves Gandon, Elise Bannier, and Pierre-Antoine Eliat
Subjects: Reproducibility, medicine.diagnostic_test, business.industry, Intraclass correlation, Gadolinium, chemistry.chemical_element, Magnetic resonance imaging, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Software, chemistry, 030220 oncology & carcinogenesis, Dynamic contrast-enhanced MRI, Analysis software, Medicine, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, Longitudinal Relaxation Time
Abstract: PURPOSE: To test the reproducibility and accuracy of pharmacokinetic parameter measurements on five analysis software packages (SPs) for dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), using simulated and clinical data. MATERIALS AND METHODS: This retrospective study was Institutional Review Board-approved. Simulated tissues consisted of pixel clusters of calculated dynamic signal changes for combinations of Tofts model pharmacokinetic parameters (volume transfer constant [K(trans) ], extravascular extracellular volume fraction [ve ]), longitudinal relaxation time (T1 ). The clinical group comprised 27 patients treated for rectal cancer, with 36 3T DCE-MR scans performed between November 2012 and February 2014, including dual-flip-angle T1 mapping and a dynamic postcontrast T1 -weighted, 3D spoiled gradient-echo sequence. The clinical and simulated images were postprocessed with five SPs to measure K(trans) , ve , and the initial area under the gadolinium curve (iAUGC). Modified Bland-Altman analysis was conducted, intraclass correlation coefficients (ICCs) and within-subject coefficients of variation were calculated. RESULTS: Thirty-one examinations from 23 patients were of sufficient technical quality and postprocessed. Measurement errors were observed on the simulated data for all the pharmacokinetic parameters and SPs, with a bias ranging from -0.19 min(-1) to 0.09 min(-1) for K(trans) , -0.15 to 0.01 for ve , and -0.65 to 1.66 mmol.L(-1) .min for iAUGC. The ICC between SPs revealed moderate agreement for the simulated data (K(trans) : 0.50; ve : 0.67; iAUGC: 0.77) and very poor agreement for the clinical data (K(trans) : 0.10; ve : 0.16; iAUGC: 0.21). CONCLUSION: Significant errors were found in the calculated DCE-MRI pharmacokinetic parameters for the perfusion analysis SPs, resulting in poor inter-software reproducibility. J. Magn. Reson. Imaging 2015
Published: 2015

26. Discovery of a planetary-mass companion within the gap of the transition disk around PDS 70

Author: Jean-Loup Baudino, Janis Hagelberg, Christophe Pinte, Cyril Petit, Quentin Kral, A. Delboulbe, A. Pohl, Pierre Baudoz, Anne-Lise Maire, Eric Stadler, T. O. B. Schmidt, Alain Origne, F. Madec, Laura M. Pérez, N. Hubin, Enrico Giro, Marcos Suarez, Andrea Baruffolo, Anne-Marie Lagrange, Mario Flock, A. Pavlov, Jonathan Williams, P. Martinez, L. Abe, L. Gluck, Raffaele Gratton, G. Rousset, Jean-Luc Beuzit, Zahed Wahhaj, Esther Buenzli, Paul Mollière, S. S. Brems, Michael Meyer, P. Pinilla, Markus Janson, Tomas Stolker, M. Feldt, Pascal Puget, Christian Ginski, R. van Boekel, Myriam Benisty, Christoph Mordasini, D. Perret, Christian Soenke, R. G. van Holstein, D. Le Mignant, Francois Menard, F. Rigal, Patrick Rabou, Thierry Fusco, Massimo Turatto, Raphaël Galicher, J. de Boer, Th. Henning, N. Pawellek, J. Antichi, André Müller, Julien Milli, J. Lannier, Kjetil Dohlen, Ronald Roelfsema, Attila Juhasz, Yves Magnard, J. Pragt, Jean-Charles Augereau, M. Carle, Emmanuel Hugot, Miriam Keppler, Marcel Carbillet, Anthony Cheetham, Alice Zurlo, P. Blanchard, Andrea Isella, Tilman Birnstiel, S. Peretti, G. Salter, M. Bonnefoy, Juan-Luis Ramos, M. Llored, Laurent M. Mugnier, G.-D. Marleau, L. Weber, Anthony Boccaletti, Tristan Buey, Philippe Feautrier, Julien Girard, M. Kasper, Carsten Dominik, Faustine Cantalloube, Alexis Matter, Dino Mesa, Silvano Desidera, Stéphane Udry, Enrico Cascone, Arthur Vigan, Gael Chauvin, David Mouillet, C. Lazzoni, Andreas Bazzon, Riccardo Claudi, Jean-François Sauvage, Thibaut Moulin, E. Sissa, M. Cudel, Wolfgang Brandner, D. Gisler, Sascha P. Quanz, O. Moeller-Nilsson, Ralf Launhardt, Francois Wildi, M. Samland, Henning Avenhaus, Sylvain Rochat, Arnaud Sevin, Bernardo Salasnich, Maud Langlois, V. De Caprio, M. Jaquet, D. Maurel, Anne Costille, J. Kemmer, A. Roux, C. Perrot, D. Fantinel, Johan Olofsson, Cecile Gry, Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), DOTA, ONERA, Université Paris Saclay (COmUE) [Palaiseau], ONERA-Université Paris Saclay (COmUE), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), University of Oxford [Oxford], Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Physikalisches Institut [Bern], Universität Bern [Bern], Hungarian Academy of Sciences (MTA), Ludwig-Maximilians-Universität München (LMU), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Kavli Institute for Theoretical Physics [Santa Barbara] (KITP), University of California [Santa Barbara] (UCSB), University of California-University of California, INAF - Osservatorio Astrofisico di Arcetri (OAA), Stockholm University, Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory (ESO), Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Universidad de Chile, University of Arizona, Monash Centre for Astrophysics (MoCA), Monash University [Clayton], Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Institute for Astronomy (IfA), University of Hawai‘i [Mānoa] (UHM), Geneva Observatory, University of Geneva [Switzerland], Institute for Particle Physics and Astrophysics [ETH Zürich] (IPA), Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Zentrum für Astronomie der Universität Heidelberg (ZAH), Universität Heidelberg [Heidelberg], INAF - Osservatorio Astronomico di Capodimonte (OAC), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], Department of Mathematics - University of Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, NOVA Optical Infrared Instrumentation Group, Universidade de Lisboa (ULISBOA), Anton Pannekoek Institute for Astronomy, Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Eberhard Karls Universität Tübingen, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), DOTA, ONERA, Université Paris Saclay [Châtillon], Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Universiteit Leiden, University of Oxford, Universität Bern [Bern] (UNIBE), University of California [Santa Barbara] (UC Santa Barbara), University of California (UC)-University of California (UC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universidad de Chile = University of Chile [Santiago] (UCHILE), Université de Genève = University of Geneva (UNIGE), Universität Heidelberg [Heidelberg] = Heidelberg University, Universidade de Lisboa = University of Lisbon (ULISBOA), ANR-10-LABX-0056,OSUG@2020,Innovative strategies for observing and modelling natural systems(2010), European Project: 226604,EC:FP7:INFRA,FP7-INFRASTRUCTURES-2008-1,OPTICON(2009), European Project: 312430,EC:FP7:INFRA,FP7-INFRASTRUCTURES-2012-1-RTD,OPTICON(2013), and Low Energy Astrophysics (API, FNWI)
Subjects: Brightness, planets and satellites: detection, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Point source, FOS: Physical sciences, Context (language use), Astrophysics, 01 natural sciences, symbols.namesake, stars: individual: PDS 70, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Rayleigh scattering, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, Earth and Planetary Astrophysics (astro-ph.EP), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, scattering, protoplanetary disks, techniques: high angular resolution, Astronomy and Astrophysics, Radius, Astrometry, Space and Planetary Science, radiative transfer, symbols, Astrophysics::Earth and Planetary Astrophysics, Planetary mass, Astrophysics - Earth and Planetary Astrophysics
Abstract: Young circumstellar disks are of prime interest to understand the physical and chemical conditions under which planet formation takes place. Only very few detections of planet candidates within these disks exist, and most of them are currently suspected to be disk features. In this context, the transition disk around the young star PDS 70 is of particular interest, due to its large gap identified in previous observations, indicative of ongoing planet formation. We aim to search for the presence of planets and search for disk structures indicative for disk-planet interactions and other evolutionary processes. We analyse new and archival near-infrared (NIR) images of the transition disk PDS 70 obtained with the VLT/SPHERE, VLT/NaCo and Gemini/NICI instruments in polarimetric differential imaging (PDI) and angular differential imaging (ADI) modes. We detect a point source within the gap of the disk at about 195 mas (about 22 au) projected separation. The detection is confirmed at five different epochs, in three filter bands and using different instruments. The astrometry results in an object of bound nature, with high significance. The comparison of the measured magnitudes and colours to evolutionary tracks suggests that the detection is a companion of planetary mass. We confirm the detection of a large gap of about 54 au in size within the disk in our scattered light images, and detect a signal from an inner disk component. We find that its spatial extent is very likely smaller than about 17 au in radius. The images of the outer disk show evidence of a complex azimuthal brightness distribution which may in part be explained by Rayleigh scattering from very small grains. Future observations of this system at different wavelengths and continuing astrometry will allow us to test theoretical predictions regarding planet-disk interactions, planetary atmospheres and evolutionary models., Comment: 23 pages, accepted by A&A
Published: 2018

27. Comparison of

Author: Xavier, Palard-Novello, Luc, Beuzit, Giulio, Gambarota, Florence, Le Jeune, Etienne, Garin, Pierre-Yves, Salaün, Anne, Devillers, Solène, Querellou, Patrick, Bourguet, and Hervé, Saint-Jalmes
Subjects: Male, Fluorine Radioisotopes, Kinetics, Positron Emission Tomography Computed Tomography, Image Processing, Computer-Assisted, Humans, Prostatic Neoplasms, Middle Aged, Magnetic Resonance Imaging, Aged, Choline
Abstract: Fourteen patients with proven prostate cancer who underwent FCH PET/CT and multiparametric MRI were enrolled. FCH PET/CT consisted in a dual phase: early pelvic list-mode acquisition and late whole-body acquisition. FCH PET/CT and multiparametric MRI examinations were registered and tumoral volume-of-interest were drawn on the largest lesion visualized on the apparent diffusion coefficient (ADC) map and projected onto the different multiparametric MR images and FCH PET/CT images. Concerning the FCH uptake, kinetic parameters were extracted with the best model selected using the Akaike information criterion between the one- and two-tissue compartment models with an imaging-derived plasma input function. Other FCH uptake parameters (early SUVmean and late SUVmean) were extracted. Concerning functional parameters derived by MRI scan, cell density (ADC from diffusion weighting imaging) and vessel permeability (KThe one-tissue compartment model for kinetic analysis of PET images was selected. Concerning correlation analysis between PET parameters, KNo significant correlation was found between FCH PET/CT and multiparametric MRI metrics except FCH influx which is moderately linked to the vessel permeability in prostate cancer.
Published: 2018

28. Characterization of ALPAO deformable mirrors for the NAOMI VLTI Auxiliary Telescopes adaptive optics

Author: S. Guieu, Jean-Philippe Berger, Sebastien Egner, Eric Cottalorda, Pierre Haguenauer, A. Delboulbe, S. Rochat, Jean-Baptiste Le Bouquin, Thibaut Moulin, Jean-Luc Beuzit, Yves Magnard, Laurent Jocou, Christophe Vérinaud, Julien Woillez, and Frédéric Gonté
Subjects: Very Large Telescope, Astronomical optical interferometry, Computer science, Zernike polynomials, business.industry, Bandwidth (signal processing), Deformable mirror, symbols.namesake, Interferometry, Optics, Software, symbols, business, Adaptive optics
Abstract: The Very Large Telescope Interferometer Auxiliary Telescopes will soon be equipped with an adaptive optics system called NAOMI. The corrective optics deformable mirror is the commercial DM241 from ALPAO. Being part of an interferometer operating from visible to mid-infrared, the DMs of NAOMI face several challenges (high level of reliability, open-loop chopping, piston-free control, WFS/DM pupil rotation, high desired bandwidth and stroke). We here describe our extensive characterization of the DMs through measurements and simulations. We summarize the operational scenario we have defined to handle the specific mirror properties. We conclude that the ALPAO DMs have overall excellent properties that fulfill most of the stringent requirements and that deviations from specifications are easily handled. To our knowledge, NAOMI will be the first astronomical system with a command in true Zernike modes (allowing software rotation), and the first astronomical system in which a chopping is performed with the deformable mirror (5” sky, at 5 Hz).
Published: 2018

29. Discovery of a brown dwarf companion to the star HIP 64892

Author: Jacopo Antichi, L. Weber, E. Sissa, Johan Olofsson, H. Le Coroller, Markus Kasper, Damien Ségransan, Alain Roux, T. Buey, Alice Zurlo, Cyril Petit, Alain Delboulbé, Andrea Baruffolo, Thomas Henning, Arnaud Sevin, P. Blanchard, Ronald Roelfsema, Daniela Fantinel, Alain Origne, R. Ligi, Anne Costille, M. Carle, Kjetil Dohlen, François Ménard, Bernardo Salasnich, Maud Langlois, Pierre Baudoz, V. De Caprio, Enrico Giro, D. Maurel, Lyu Abe, Markus Janson, O. Möller-Nilsson, Raffaele Gratton, Jean-Luc Beuzit, Riccardo Claudi, Beth Biller, Eric Stadler, Valentina D'Orazi, Massimo Turatto, Marc Jaquet, Joshua E. Schlieder, Pascal Puget, Taisiya Kopytova, Yves Magnard, Arthur Vigan, C. Soenke, Anthony Cheetham, Anne-Lise Maire, Patrice Martinez, D. Le Mignant, Gérard Rousset, A. Pavlov, Norbert Hubin, M. Keppler, Anne-Marie Lagrange, Emmanuel Hugot, Eric Lagadec, Hubert Klahr, Daniel Rouan, Dino Mesa, Michael Meyer, Thierry Fusco, Janis Hagelberg, Markus Feldt, Philippe Feautrier, Joany Andreina Manjarres Ramos, Quentin Kral, M. Llored, E. Cascone, Marcel Carbillet, S. Rochat, T. O. B. Schmidt, Mickael Bonnefoy, T. Moulin, S. Peretti, P. Rabou, David Mouillet, L. Gluck, J. Pragt, Gael Chauvin, F. Madec, Jean-François Sauvage, Francois Wildi, C. Mordasini, Denis Perret, Carsten Dominik, Anthony Boccaletti, F. Rigal, Marcos Suarez, Stéphane Udry, Silvano Desidera, Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Universidad de Chile, Universidad de Valparaiso [Chile], Stockholm University, University of Edinburgh, Instituto de Astronomia y ciencias Planetarias de Atacama (INCT), Universidad de Atacama, University of Cambridge [UK] (CAM), NASA Goddard Space Flight Center (GSFC), University of Bern, Universidad Diego Portales [Santiago] (UDP), Institute for Particle Physics and Astrophysics [ETH Zürich] (IPA), Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Department of Mathematics - University of Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Arizona State University [Tempe] (ASU), Ural Federal University [Ekaterinburg] (UrFU), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Arcetri (OAA), INAF - Osservatorio Astronomico di Capodimonte (OAC), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), European Southern Observatory (ESO), NOVA Optical Infrared Instrumentation Group, European Southern Observatory [Santiago] (ESO), Université de Genève = University of Geneva (UNIGE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidad de Chile = University of Chile [Santiago] (UCHILE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Low Energy Astrophysics (API, FNWI), Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Institute for Astronomy [Edinburgh] (IfA), Geneva Observatory, Department of Biochemistry and Molecular Biology, Mayo Clinic, Observatoire de Paris, Université Paris sciences et lettres (PSL), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], INDIVIDUAL: HIP 64892 [STARS], HIGH ANGULAR RESOLUTIONS [TECHNIQUES], 530 Physics, Astrophysics::High Energy Astrophysical Phenomena, BROWN DWARFS, FOS: Physical sciences, Library science, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, DETECTIONS [PLANETS AND SATELLITES], OPTIQUE ADAPTATIVE, 01 natural sciences, Techniques: high angular resolution, VLT, 0103 physical sciences, DETECTION [PLANETS AND SATELLITES], Astrophysics::Solar and Stellar Astrophysics, European commission, 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics::Galaxy Astrophysics, Stars: brown dwarfs individual: HIP 64892, HIGH ANGULAR RESOLUTION [TECHNIQUES], Earth and Planetary Astrophysics (astro-ph.EP), Physics, ASTRONOMIE, INDIVIDUAL [STARS], 010308 nuclear & particles physics, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], 520 Astronomy, EFFECTIVE TEMPERATURE, Astronomy and Astrophysics, Planets and satellites: detection, 500 Science, 620 Engineering, EVOLUTIONARY MODELS, Astrophysics - Solar and Stellar Astrophysics, FORMATION AND EVOLUTIONS, Space and Planetary Science, ATMOSPHERES [SATELLITES], SPECTRAL ENERGY DISTRIBUTION, Christian ministry, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], SATELLITES, STARS, Astrophysics - Earth and Planetary Astrophysics, PLANETS
Abstract: We report the discovery of a bright, brown dwarf companion to the star HIP 64892, imaged with VLT/SPHERE during the SHINE exoplanet survey. The host is a B9.5V member of the Lower-Centaurus-Crux subgroup of the Scorpius Centaurus OB association. The measured angular separation of the companion ($1.2705\pm0.0023$") corresponds to a projected distance of $159\pm12$ AU. We observed the target with the dual-band imaging and long-slit spectroscopy modes of the IRDIS imager to obtain its SED and astrometry. In addition, we reprocessed archival NACO L-band data, from which we also recover the companion. Its SED is consistent with a young (, Comment: 12 pages, 11 figures, accepted for publication in A&A
Published: 2018

30. Low wind effect on VLT/SPHERE: impact, mitigation strategy, and results

Author: Jean-François Sauvage, Arthur Vigan, Julien Milli, Konrad Tristam, Alexander Telle, Mamadou N'Diaye, Dimitri Mawet, David Mouillet, Zahed Wahhaj, Julien Girard, Cyril Pannetier, Claudia Reyes, Pierre Bourget, Thierry Fusco, Faustine Cantalloube, Jean-Luc Beuzit, Markus Kasper, European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), California Institute of Technology (CALTECH), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Close, Laird M., Schreiber, Laura, and Schmidt, Dirk
Subjects: Wavefront, Radiative cooling, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Image quality, business.industry, Phase (waves), Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, 01 natural sciences, law.invention, 010309 optics, Telescope, Low emissivity, Cardinal point, Optics, 13. Climate action, law, 0103 physical sciences, Environmental science, Adaptive optics, business, Astrophysics - Instrumentation and Methods for Astrophysics, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract: The low wind effect is a phenomenon disturbing the phase of the wavefront in the pupil of a large telescope obstructed by spiders, in the absence of wind. It can be explained by the radiative cooling of the spiders, creating air temperature inhomogeneities across the pupil. Because it is unseen by traditional adaptive optics (AO) systems, thus uncorrected, it significantly degrades the quality of AO-corrected images. We provide a statistical analysis of the strength of this effect as seen by VLT/SPHERE after 4 years of operations. We analyse its dependence upon the wind and temperature conditions. We describe the mitigation strategy implemented in 2017: a specific coating with low thermal emissivity in the mid-infrared was applied on the spiders of Unit Telescope 3. We quantify the improvement in terms of image quality, contrast and wave front error using both focal plane images and measured phase maps., Comment: 20 pages, 21 figures, SPIE 2018 conference proceeding
Published: 2018

31. Statistical analysis and lessons learned of SPHERE adaptive optics performance

Author: Faustine Cantalloube, Jean-Luc Beuzit, Gael Chauvin, Carlos Correia, A. M. Lagrange, Cyril Pannetier, Kjetil Dohlen, D. Mouillet, N. Meunier, Arthur Vigan, T. Fusco, Markus Kasper, P. Delorme, D. Albert, A. Boccaletti, Julien Milli, J. F. Sauvage, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Unidad Mixta Internacional Franco-Chilena de Astromia, Universidad de Chile (CNRS/INSU), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], business.industry, Computer science, 0103 physical sciences, Statistical analysis, Artificial intelligence, 010306 general physics, business, Adaptive optics, 010303 astronomy & astrophysics, 01 natural sciences
Abstract: International audience; The SPHERE instrument, dedicated to high contrast imaging on VLT, has been routinely operated for more than 3 years, over a large range of conditions and producing observations from visible to NIR. A central part of the instrument is the high order adaptive optics system, named SAXO, designed to deliver high Strehl image quality with a balanced performance budget for bright stars up to magnitude R=9. We take benefit now from the very large set of observations to revisit the assumptions and analysis made at the time of the design phase: we compare the actual AO behavior as a function of expectations. The data set consists of the science detector data, for both coronagraphic images and non-coronagraphic PSF calibrations, but also of AO internal data from the high frequency sensors and statistics computations from the real-time computer which are systematically archived, and finally of environmental data, monitored at VLT level. This work is supported and made possible by the SPHERE « Data Center » infrastructure hosted at Grenoble which provides an efficient access and the capability for the homogeneous analysis of this large and statistically-relevant data set. We review in a statistical manner the actual AO performance as a function of external conditions for different regimes and we discuss the possible performance metrics, either derived from AO internal data or directly from the high contrast images. We quantify the dependency of the actual performance on the most relevant environmental parameters. By comparison to earlier expectations, we conclude on the reliability of the usual AO modeling. We propose some practical criteria to optimize the queue scheduling and the expression of observer requirements ; finally, we revisit what could be the most important AO specifications for future high contrast imagers as a function of the primary science goals, the targets and the turbulence properties.
Published: 2018

32. High-contrast observations of circumstellar environments with GTC/FRIDA: design and study of the coronagraphic devices

Author: Mickael Bonnefoy, Mamadou N'Diaye, Jean-Luc Beuzit, Arthur Vigan, Kjetil Dohlen, B. Sánchez, Alexis Carlotti, S. Cuevas, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Gran Telescopio Canarias, Computer science, Strehl ratio, Astronomy, Spectral bands, 01 natural sciences, Exoplanet, law.invention, 010309 optics, Telescope, Stars, Integral field spectrograph, law, 0103 physical sciences, Adaptive optics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS
Abstract: Over the past few years, several large ground-based facilities have enhanced their exoplanet direct imaging capabilities to observe planetary companions and debris disks around nearby stars. The Gran Telescopio Canarias (GTC) will soon have its first high-contrast capabilities with FRIDA. This near-infrared imager and integral field spectrograph will operate with GTCAO, the adaptive optics system of the telescope, to cover a broad range of astrophysical topics. In 2008, we performed preliminary studies to design a high-contrast mode for FRIDA. In this communication, we revisit these studies by investigating different options in coronagraphy to define a final high-contrast baseline for this instrument. Acknowledging the mechanical constraints of FRIDA and the GTCAO performance for high-contrast observations (60% Strehl ratio in K-band), we evaluate different options such as standalone pupil apodizations and classical Lyot coronagraphs to achieve a 10 −5 contrast at 200-300 mas from an observed star over wide spectral bands. We then derive the adopted solutions for design and manufacturing of the prototypes. Finally, we discuss possible combinations of high-dispersion spectroscopy and high-contrast imaging for advanced exoplanet observations with this instrument.
Published: 2018

33. On-sky compensation of non-common path aberrations with the ZELDA wavefront sensor in VLT/SPHERE

Author: R. Pourcelot, Julien Milli, David Mouillet, Mamadou N'Diaye, Kjetil Dohlen, Jean-Luc Beuzit, Zahed Wahhaj, Arthur Vigan, Gerard Zins, Jean-François Sauvage, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory (ESO), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), and Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Zernike polynomials, media_common.quotation_subject, FOS: Physical sciences, 01 natural sciences, Prime (order theory), 010309 optics, symbols.namesake, Optics, Planet, 0103 physical sciences, Calibration, Astrophysics::Solar and Stellar Astrophysics, Adaptive optics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, media_common, Physics, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Wavefront sensor, Exoplanet, Sky, symbols, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Circumstellar environments are now routinely observed by dedicated high-contrast imagers on large, ground-based observatories. These facilities combine extreme adaptive optics and coronagraphy to achieve unprecedented sensitivities for exoplanet detection and spectral characterization. However, non-common path aberrations (NCPA) in these coronagraphic systems represent a critical limitation for the detection of giant planets with a contrast lower than a few $10^{-6}$ at very small separations ($, Comment: 9 pages, 4 figures. Proceeding of the SPIE Astronomical Telescopes + Instrumentation Conference, 10 - 15 June 2018
Published: 2018

34. Bringing high-spectral resolution to VLT/SPHERE with a fiber coupling to VLT/CRIRES+

Author: Gilles Otten, Reinhold J. Dorn, M. Kasper, Isabelle Baraffe, Eduard Muslimov, Jean-Luc Beuzit, M. W. Philipps, Arthur Vigan, Ulf Seemann, Ansgar Reiners, David Mouillet, and Kjetil Dohlen
Subjects: Physics, Coupling, Very Large Telescope, 010504 meteorology & atmospheric sciences, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, 01 natural sciences, Exoplanet, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Spectral resolution, Spectroscopy, 010303 astronomy & astrophysics, Image resolution, Spectrograph, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences
Abstract: Atmospheric composition provides essential markers of the most fundamental properties of giant exoplanets, such as their formation mechanism or internal structure. New-generation exoplanet imagers, like VLT/SPHERE or Gemini/GPI, have been designed to achieve very high contrast (< 15 mag) at small angular separations (
Published: 2018
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35. Imaging radial velocity planets with SPHERE

Author: Anne-Marie Lagrange, Clément Perrot, Claire Moutou, Arthur Vigan, P. J. Potiron, Dino Mesa, Jose Ramos, C. Petit, Esther Buenzli, Mickael Bonnefoy, Matthias Meyer, Tanmay Bhowmik, Markus Feldt, Silvano Desidera, Maud Langlois, Anne-Lise Maire, Markus Janson, Graeme Salter, C. Lazzoni, T. Schmidt, Jean-Luc Beuzit, Alain Delboulbé, M. Cudel, Beth Biller, Mariangela Bonavita, Wolfgang Brandner, S. Peretti, Sylvain Rochat, Janis Hagelberg, Valentina D'Orazi, Anthony Boccaletti, Alice Zurlo, Baptiste Lavie, Sergio Messina, Raffaele Gratton, F. Rigal, Gael Chauvin, David Mouillet, J. Lannier, E. Sissa, Universidad Diego Portales [Santiago] (UDP), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Instituto de Astronomia y ciencias Planetarias de Atacama (INCT), Universidad de Atacama, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), INAF - Osservatorio Astrofisico di Catania (OACT), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), University of Edinburgh, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Institute for Particle Physics and Astrophysics [ETH Zürich] (IPA), Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Stockholm University, Centre de Recherche Astrophysique de Lyon (CRAL), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), University of Michigan [Ann Arbor], University of Michigan System, Observatoire de la Côte d'Azur (OCA), Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay (COmUE) [Palaiseau], ONERA-Université Paris Saclay (COmUE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: FOS: Physical sciences, spectrographs -methods: data analysis [Instrumentation], Astrophysics, 01 natural sciences, GJ 676A, 010309 optics, ETOILE, [SPI]Engineering Sciences [physics], RADIAL VELOCITY, individual: HD142 [Stars], Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, ANALYSE DONNEES, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Earth and Planetary Astrophysics (astro-ph.EP), Physics, [PHYS]Physics [physics], SPECTROGRAPHE, radial velocities [Techniques], imaging spectroscopy [Techniques], IMAGING SPECTROSCOPY, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, Planetary system, Exoplanet, Starlight, Radial velocity, Stars, Orbit, Planetary systems, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, [SDU]Sciences of the Universe [physics], HD39091, HIP 70849, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, SYSTEME PLANETAIRE, Astrophysics - Earth and Planetary Astrophysics, Data reduction
Abstract: We present observations with the planet finder SPHERE of a selected sample of the most promising radial velocity (RV) companions for high-contrast imaging. Using a Monte Carlo simulation to explore all the possible inclinations of the orbit of wide RV companions, we identified the systems with companions that could potentially be detected with SPHERE. We found the most favorable RV systems to observe are : HD\,142, GJ\,676, HD\,39091, HIP\,70849, and HD\,30177 and carried out observations of these systems during SPHERE Guaranteed Time Observing (GTO). To reduce the intensity of the starlight and reveal faint companions, we used Principle Component Analysis (PCA) algorithms alongside angular and spectral differential imaging. We injected synthetic planets with known flux to evaluate the self-subtraction caused by our data reduction and to determine the 5$\sigma$ contrast in the J band $vs$ separation for our reduced images. We estimated the upper limit on detectable companion mass around the selected stars from the contrast plot obtained from our data reduction. Although our observations enabled contrasts larger than 15 mag at a few tenths of arcsec from the host stars, we detected no planets. However, we were able to set upper mass limits around the stars using AMES-COND evolutionary models. We can exclude the presence of companions more massive than 25-28 \MJup around these stars, confirming the substellar nature of these RV companions., Comment: 14 pages, 11 figures, accepted by MNRAS
Published: 2018

36. Shadows and spirals in the protoplanetary disk HD 100453

Author: C. Fontanive, Alice Zurlo, Christian Ginski, Thomas Henning, Paola Pinilla, Tomas Stolker, M. Llored, Maud Langlois, D. Gisler, O. Moeller-Nilsson, R. van Boekel, J. Pragt, Yves Magnard, Kevin Wagner, François Ménard, Jean-François Sauvage, Silvano Desidera, Antonio Garufi, David Mouillet, Geoffroy Lesur, Francois Wildi, M. Bonnefoy, Myriam Benisty, T. Buey, Raffaele Gratton, Arthur Vigan, Gael Chauvin, Anthony Boccaletti, Michiel Min, A-M. Lagrange, Jacopo Antichi, Thierry Fusco, Markus Feldt, Christophe Pinte, H. LeCoroller, Carsten Dominik, Jean-Luc Beuzit, M. Cudel, E. Sissa, Dino Mesa, J. de Boer, Attila Juhasz, Ronald Roelfsema, Cornelis P. Dullemond, M. Kasper, Stefano Facchini, Adriana Pohl, Daniel Apai, Sascha P. Quanz, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Astronomical Institute Anton Pannekoek, University of Amsterdam, Max-Planck-Institut für Astronomie (MPIA), Leiden Observatory, Institute of Earth Sciences, Heidelberg University, Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), SRON Netherlands Institute for Space Research, Department of Astronomy, Steward Observatory, Institute of Astronomy, Madingley Road, Cambridge CB3, OHA, UK, Max-Planck-Institut fur extraterrestrische Physik, Universidad Autononoma de Madrid, Dpto. Fisica Teorica, Facultad de Ciencias, Campus de Cantoblanco, 28049, Madrid, Spain, Institute for Astronomy, Department of Physics, ETH Zürich, Nucleo de Astronomia, Facultad de Ingenieria, Universidad Diego Portales, Av. Ejercito 441, Santiago, Chile, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), INAF-Osservatorio Astronomico di Padova, Institute for Astronomy, Blackford Hill, European Southern Observatory (ESO), INAF-Osservatorio Astrofisico di Arcetri (INAF-OAA), ONERA, Geneva Observatory, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Max-Planck-Gesellschaft, Leiden Observatory [Leiden], Universiteit Leiden, Institute for Theoretical Astrophysics [Heidelberg], Heidelberg University, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), SRON Netherlands Institute for Space Research (SRON), Steward Observatory (STEWARD OBSERVATORY), University of Arizona, Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Max-Planck-Institut für Extraterrestrische Physik (MPE), Universidad Autonónoma de Madrid, Institute of Astronomy [ETH Zürich], Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Universidad Diego Portales [Santiago] (UDP), Universidade do Chile, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, ESO, Physics Department [Garching], Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), ONERA - The French Aerospace Lab [Châtillon], ONERA-Université Paris Saclay (COmUE), Kiepenheuer-Institut für Sonnenphysik (KIS), Université de Genève = University of Geneva (UNIGE), Universiteit Leiden [Leiden], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), University of Geneva [Switzerland], Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Technical University of Munich (TUM)-Technical University of Munich (TUM), Low Energy Astrophysics (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: Brightness, FOS: Physical sciences, Astrophysics, RADIATIVE TRANSFER, Astrophysics::Cosmology and Extragalactic Astrophysics, Protoplanetary disk, OPTIQUE ADAPTATIVE, 01 natural sciences, VLT, POLARIMETRIE, POLARIMETRIC, Planet, SPHERE, 0103 physical sciences, TECHNIQUES, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, Earth and Planetary Astrophysics (astro-ph.EP), Inclined orbit, Spiral galaxy, 010308 nuclear & particles physics, Scattering, protoplanetary disks, Astronomy and Astrophysics, Scale height, TRANSFERT RADIATIF, Wavelength, techniques: polarimetric, Space and Planetary Science, [SDU]Sciences of the Universe [physics], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Astrophysics - Earth and Planetary Astrophysics
Abstract: Understanding the diversity of planets requires to study the morphology and the physical conditions in the protoplanetary disks in which they form. We observed and spatially resolved the disk around the ~10 Myr old protoplanetary disk HD 100453 in polarized scattered light with SPHERE/VLT at optical and near-infrared wavelengths, reaching an angular resolution of ~0.02", and an inner working angle of ~0.09". We detect polarized scattered light up to ~0.42" (~48 au) and detect a cavity, a rim with azimuthal brightness variations at an inclination of 38 degrees, two shadows and two symmetric spiral arms. The spiral arms originate near the location of the shadows, close to the semi major axis. We detect a faint spiral-like feature in the SW that can be interpreted as the scattering surface of the bottom side of the disk, if the disk is tidally truncated by the M-dwarf companion currently seen at a projected distance of ~119 au. We construct a radiative transfer model that accounts for the main characteristics of the features with an inner and outer disk misaligned by ~72 degrees. The azimuthal brightness variations along the rim are well reproduced with the scattering phase function of the model. While spirals can be triggered by the tidal interaction with the companion, the close proximity of the spirals to the shadows suggests that the shadows could also play a role. The change in stellar illumination along the rim, induces an azimuthal variation of the scale height that can contribute to the brightness variations. Dark regions in polarized images of transition disks are now detected in a handful of disks and often interpreted as shadows due to a misaligned inner disk. The origin of such a misalignment in HD 100453, and of the spirals, is unclear, and might be due to a yet-undetected massive companion inside the cavity, and on an inclined orbit., Comment: A&A, accepted
Published: 2017

37. Combining angular differential imaging and accurate polarimetry with SPHERE/IRDIS to characterize young giant exoplanets

Author: Christoph U. Keller, Alice Zurlo, Daphne Stam, Maud Langlois, Julien Girard, Jozua de Boer, David Mouillet, Remco de Kok, Rob G. van Holstein, Christian Ginski, Markus Kasper, Frans Snik, Jean-Luc Beuzit, Arthur Vigan, Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Leiden Observatory [Leiden], Universiteit Leiden, Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), European Southern Observatory (ESO), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Shaklan, S, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Universiteit Leiden [Leiden], Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES)
Subjects: Polarimetry, data, FOS: Physical sciences, reduction, 01 natural sciences, law.invention, Telescope, HR 8799, Optics, law, angular difierential imaging, 0103 physical sciences, angular differential imaging, Mueller calculus, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, polarimetry, Earth and Planetary Astrophysics (astro-ph.EP), Physics, instrumental polarization * Observations were made with ESO Telescopes at the La Silla Paranal Observatory under program ID: 098C-0790(A), datareduction, 010308 nuclear & particles physics, business.industry, Linear polarization, Cloud top, SPHERE/IRDIS, Astrophysics::Instrumentation and Methods for Astrophysics, Speckle noise, Polarization (waves), Exoplanet, PZ Tel, exoplanets, 13. Climate action, instrumental polarization, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Earth and Planetary Astrophysics
Abstract: Young giant exoplanets emit infrared radiation that can be linearly polarized up to several percent. This linear polarization can trace: 1) the presence of atmospheric cloud and haze layers, 2) spatial structure, e.g. cloud bands and rotational flattening, 3) the spin axis orientation and 4) particle sizes and cloud top pressure. We introduce a novel high-contrast imaging scheme that combines angular differential imaging (ADI) and accurate near-infrared polarimetry to characterize self-luminous giant exoplanets. We implemented this technique at VLT/SPHERE-IRDIS and developed the corresponding observing strategies, the polarization calibration and the data-reduction approaches. By combining ADI and polarimetry we can characterize planets that can be directly imaged with a very high signal-to-noise ratio. We use the IRDIS pupil-tracking mode and combine ADI and principal component analysis to reduce speckle noise. We take advantage of IRDIS' dual-beam polarimetric mode to eliminate differential effects that severely limit the polarimetric sensitivity (flat-fielding errors, differential aberrations and seeing), and thus further suppress speckle noise. To correct for instrumental polarization effects, we apply a detailed Mueller matrix model that describes the telescope and instrument and that has an absolute polarimetric accuracy $\leq0.1\%$. Using this technique we have observed the planets of HR 8799 and the (sub-stellar) companion PZ Tel B. Unfortunately, we do not detect a polarization signal in a first analysis. We estimate preliminary $1\sigma$ upper limits on the degree of linear polarization of $\sim1\%$ and $\sim0.1\%$ for the planets of HR 8799 and PZ Tel B, respectively. The achieved sub-percent sensitivity and accuracy show that our technique has great promise for characterizing exoplanets through direct-imaging polarimetry., Comment: 16 pages, 8 figures, 2 tables; v2: added acknowledgement and corrected two typos
Published: 2017

38. Detection and characterisation of 54 massive companions with the SOPHIE spectrograph

Author: M. J. Hobson, S. Borgniet, Vincent Bourrier, Isabelle Boisse, Nuno C. Santos, C. Lovis, Damien Ségransan, S. Dalal, T. Forveille, C. Perrier, G. Montagnier, M. Mayor, Janis Hagelberg, Nathan Hara, S. G. Sousa, Luc Arnold, Johannes Sahlmann, Alfred Vidal-Madjar, A. Santerne, Francesco Pepe, Guillaume Hébrard, Rodrigo F. Díaz, Jean-Luc Beuzit, Stéphane Udry, Flavien Kiefer, François Bouchy, C. Moutou, Paul Wilson, X. Delfosse, Olivier Demangeon, David Ehrenreich, J. Rey, Gregory W. Henry, B. Courcol, Nicola Astudillo-Defru, Anne-Marie Lagrange, Magali Deleuil, and X. Bonfils
Subjects: Physics, 010308 nuclear & particles physics, Molecular cloud, Brown dwarf, Astronomy and Astrophysics, Context (language use), Astrophysics, Orbital period, 01 natural sciences, Radial velocity, Stars, Space and Planetary Science, Planet, 0103 physical sciences, Gravitational collapse, 010303 astronomy & astrophysics
Abstract: Context. Brown dwarfs (BD) are substellar objects intermediate between planets and stars with masses of ~13–80 MJ. While isolated BDs are most likely produced by gravitational collapse in molecular clouds down to masses of a few MJ, a non-negligible fraction of low-mass companions might be formed through the planet-formation channel in protoplanetary discs. The upper mass limit of objects formed within discs is still observationally unknown, the main reason being the strong dearth of BD companions at orbital periods shorter than 10 yr, also known as the BD desert. Aims. To address this question, we aim at determining the best statistics of companions within the 10–100 MJ mass regime and located closer than ~10 au to the primary star, while minimising observation and selection bias. Methods. We made extensive use of the radial velocity (RV) surveys of northern hemisphere FGK stars within 60 pc of the Sun, performed with the SOPHIE spectrograph at the Observatoire de Haute-Provence. We derived the Keplerian solutions of the RV variations of 54 sources. Public astrometric data of the HIPPARCOS and Gaia missions allowed us to constrain the masses of the companions for most sources. We introduce GASTON, a new method to derive inclination combining RVs and Keplerian and astrometric excess noise from Gaia DR1. Results. We report the discovery of 12 new BD candidates. For five of them, additional astrometric data led to a revision of their mass in the M-dwarf regime. Among the seven remaining objects, four are confirmed BD companions, and three others are likely also in this mass regime. Moreover, we report the detection of 42 M-dwarfs within the range of 90 MJ–0.52 M⊙. The resulting M sin i-P distribution of BD candidates shows a clear drop in the detection rate below 80-day orbital period. Above that limit, the BD desert appears rather wet, with a uniform distribution of the M sin i. We derive a minimum BD-detection frequency around Solar-like stars of 2.0 ± 0.5%.
Published: 2019

39. Calibration of quasi-static aberrations in exoplanet direct-imaging instruments with a Zernike phase-mask sensor

Author: Z. Wahhaj, A. Caillat, J. Le Merrer, Jean-François Sauvage, David Mouillet, Julien Milli, Arthur Vigan, Kjetil Dohlen, Mamadou N'Diaye, A. Costille, Faustine Cantalloube, Gerard Zins, Jean-Luc Beuzit, Cyril Petit, Alexis Carlotti, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), European Southern Observatory (ESO), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Subjects: Zernike polynomials, FOS: Physical sciences, Astrophysics, 01 natural sciences, Deformable mirror, law.invention, 010309 optics, Telescope, symbols.namesake, Optics, law, 0103 physical sciences, Adaptive optics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Coronagraph, ComputingMilieux_MISCELLANEOUS, Wavefront, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], business.industry, Strehl ratio, Astronomy and Astrophysics, Wavefront sensor, [SDU]Sciences of the Universe [physics], Space and Planetary Science, symbols, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract: Second-generation exoplanet imagers using extreme adaptive optics and coronagraphy have demonstrated their great potential for studying close circumstellar environments and for detecting new companions and helping to understand their physical properties. However, at very small angular separation, their performance in contrast is limited by several factors: diffraction by the complex telescope pupil not perfectly canceled by the coronagraph, residual dynamic wavefront errors, chromatic wavefront errors, and wavefront errors resulting from noncommon path aberrations (NCPAs). In a previous work, we demonstrated the use of a Zernike wavefront sensor called ZELDA for sensing NCPAs in VLT/SPHERE and their compensation. In the present work, we move to the next step with the on-sky validation of NCPA compensation with ZELDA. We start by reproducing previous results on the internal source and show that the amount of aberration integrated between 1 and 15 cycles/pupil is decreased by a factor of five, which translates into a gain in raw contrast of between 2 and 3 below 300 mas. On sky, we demonstrate that NCPA compensation works in closed loop, leading to an attenuation of the amount of aberration by a factor of approximately two. However, we identify a loss of sensitivity for the sensor that is only partly explained by the difference in Strehl ratio between the internal and on-sky measurements. Coronagraphic imaging on sky is improved in raw contrast by a factor of 2.5 at most in the ExAO-corrected region. We use coronagraphic image reconstruction based on a detailed model of the instrument to demonstrate that both internal and on-sky raw contrasts can be precisely explained, and we establish that the observed performance after NCPA compensation is no longer limited by an improper compensation for aberration but by the current apodized-pupil Lyot coronagraph design. [abridged], 17 pages, 13 figures. Accepted for publication in A&A
Published: 2019

40. NAOMI: a low-order adaptive optics system for the VLT interferometer

Author: Pavel Shchkaturov, Julien Woillez, Angela Cortes, Javier Reyes, Jean-Baptiste Le Bouquin, Norbert Hubin, Paul Jolley, Rob Donaldson, Jean-Jacques Correia, Yves Magnard, F. Delplancke-Ströbele, Marcos Suarez, Laurence Michaud, Thanh Phan Duc, Sebastian Egner, Emmanuel Aller-Carpentier, Miska Le Louarn, J. Quentin, Stefan Huber, T. Moulin, Frédéric Gonté, Luca Pasquini, Luigi Andolfato, Jaime Alonso, Guillermo Valdes, R. Ridings, Reinhold J. Dorn, Didier Maurel, Jean-Philippe Berger, Paul Lilley, Sylvain Rochat, Christophe Dupuy, Alessandro Martis, Alain Roux, Jerome Paufique, J. P. Kirchbauer, Jean-Luc Beuzit, Christophe Verinaud, Alain Delboulbé, and Eric Stadler
Subjects: Physics, Wavefront, Interferometry, Optics, 010308 nuclear & particles physics, business.industry, 0103 physical sciences, Astronomical interferometer, Strehl ratio, business, Adaptive optics, 010303 astronomy & astrophysics, 01 natural sciences
Abstract: The New Adaptive Optics Module for Interferometry (NAOMI) will be developed for and installed at the 1.8-metre Auxiliary Telescopes (ATs) at ESO Paranal. The goal of the project is to equip all four ATs with a low-order Shack– Hartmann adaptive optics system operating in the visible. By improving the wavefront quality delivered by the ATs for guide stars brighter than R = 13 mag, NAOMI will make the existing interferometer performance less dependent on the seeing conditions. Fed with higher and more stable Strehl, the fringe tracker(s) will achieve the fringe stability necessary to reach the full performance of the second-generation instruments GRAVITY and MATISSE.
Published: 2016

41. EPICS, the exoplanet imager for the E-ELT

Author: Sebastian Wolf, Natalia Yaitskova, Pierre Baudoz, Florian Kerber, Kjetil Dohlen, Raffaele Gratton, Ronald Roelfsema, Jean-Luc Beuzit, Christophe Vérinaud, Markus Feldt, Anthony Boccaletti, Lars Venema, Niranjan Thatte, Hans Martin Schmid, Norbert Hubin, Markus Kasper, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Pôle Astronomie du LESIA, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris
Subjects: Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Direct imaging, High contrast imaging, Exoplanet, Conceptual design, Planet, Astrophysics::Solar and Stellar Astrophysics, Terrestrial planet, Astrophysics::Earth and Planetary Astrophysics, Adaptive optics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics::Galaxy Astrophysics
Abstract: Presently, dedicated instrument developments at large telescopes (SPHERE for the VLT, GPI for Gemini) are about to discover and explore self-luminous giant planets by direct imaging and spectroscopy. The next generation of 30m-40m ground-based telescopes, the Extremely Large Telescopes (ELTs), have the potential to dramatically enlarge the discovery space towards older giant planets seen in reflected light and ultimately even a small number of rocky planets. EPICS is a proposed instrument for the European ELT, dedicated to the detection and characterization of expolanets by direct imaging and spectroscopy. ESO recently launched a phase-A study for EPICS with a large European consortium which - by simulations and demonstration experiments - will investigate state-of-the-art diffraction and speckle suppression techniques to deliver highest contrasts. The final result of the study in 2010 will be a conceptual design and a development plan for the instrument. Here we present first results from the phase-A study and discuss the main challenges and science capabilities of EPICS.
Published: 2016

42. Smart warping harnesses for active mirrors and stress polishing

Author: Anne Costille, Kjetil Dohlen, Emmanuel Hugot, Michel Marcos, Gabby Kroes, Jean-Luc Beuzit, Jean-Gabriel Cuby, Hermine Schnetler, Z. Challita, and Sabri Lemared
Subjects: business.industry, Computer science, Mechanical engineering, Polishing, Active optics, 02 engineering and technology, Astigmatism, medicine.disease, 01 natural sciences, Finite element method, 010309 optics, Stress (mechanics), 020210 optoelectronics & photonics, Optics, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, medicine, Image warping, business, Actuator
Abstract: We present two ways to generate or compensate for first order optical aberrations using smart warping harnesses. In these cases, we used the same methodology leading to replace a previous actuation system currently on-sky and to get a freeform mirror intended to a demonstrator. Starting from specifications, a warping harness is designed, followed by a meshing model in the finite elements software. For the two projects, two different ways of astigmatism generation are presented. The first one, on the VLT-SPHERE instrument, with a single actuator, is able to generate a nearly pure astigmatism via a rotating motorization. Two actuators are sufficient to produce the same aberration for the active freeform mirror, main part of the OPTICON-FAME project, in order to use stress-polishing method.
Published: 2016

43. The SOPHIE search for northern extrasolar planets XI. Three new companions and an orbit update: Giant planets in the habitable zone

Author: David Ehrenreich, Francesco Pepe, X. Delfosse, Vincent Bourrier, B. Courcol, Xavier Bonfils, Didier Queloz, Nicola Astudillo-Defru, Isabelle Boisse, J. Rey, S. Borgniet, Rodrigo F. Díaz, Stéphane Udry, Luc Arnold, Jean-Luc Beuzit, Nuno C. Santos, Damien Ségransan, Magali Deleuil, Paul Wilson, Alexandre Santerne, T. Forveille, F. Bouchy, A-M. Lagrange, Johannes Sahlmann, Guillaume Hébrard, Michel Mayor, C. Moutou, Olivier Demangeon, Département RadioChimie et Procédés (DRCP), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris-Sud - Paris 11 (UP11), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève = University of Geneva (UNIGE), Canada-France-Hawaii Telescope Corporation (CFHT), National Research Council of Canada (NRC)-Centre National de la Recherche Scientifique (CNRS)-University of Hawai'i [Honolulu] (UH), Centro de Astrofísica da Universidade do Porto (CAUP), Universidade do Porto = University of Porto, Departamento de Física e Astronomia [Porto] (DFA/FCUP), Faculdade de Ciências da Universidade do Porto (FCUP), Universidade do Porto = University of Porto-Universidade do Porto = University of Porto, Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut de Recherche pour le Développement (IRD), Université de Genève (UNIGE), Universidade do Porto, Universidade do Porto-Universidade do Porto, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Canada-France-Hawaii Telescope Corporation, Universidade do Porto [Porto], and Departamento de Física e Astronomia [Porto]
Subjects: Physics, Orbital elements, Earth and Planetary Astrophysics (astro-ph.EP), 010504 meteorology & atmospheric sciences, Brown dwarf, Giant planet, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Planetary system, 01 natural sciences, Exoplanet, Radial velocity, 13. Climate action, Space and Planetary Science, Planet, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, Circumstellar habitable zone, 0105 earth and related environmental sciences, Astrophysics - Earth and Planetary Astrophysics
Abstract: We report the discovery of three new substellar companions to solar-type stars, HD191806, HD214823, and HD221585, based on radial velocity measurements obtained at the Haute-Provence Observatory. Data from the SOPHIE spectrograph are combined with observations acquired with its predecessor, ELODIE, to detect and characterise the orbital parameters of three new gaseous giant and brown dwarf candidates. Additionally, we combine SOPHIE data with velocities obtained at the Lick Observatory to improve the parameters of an already known giant planet companion, HD16175 b. Thanks to the use of different instruments, the data sets of all four targets span more than ten years. Zero-point offsets between instruments are dealt with using Bayesian priors to incorporate the information we possess on the SOPHIE/ELODIE offset based on previous studies. The reported companions have orbital periods between three and five years and minimum masses between 1.6 Mjup and 19 Mjup. Additionally, we find that the star HD191806 is experiencing a secular acceleration of over 11 \ms\ per year, potentially due to an additional stellar or substellar companion. A search for the astrometric signature of these companions was carried out using Hipparcos data. No orbit was detected, but a significant upper limit to the companion mass can be set for HD221585, whose companion must be substellar. With the exception of HD191806 b, the companions are located within the habitable zone of their host star. Therefore, satellites orbiting these objects could be a propitious place for life to develop., Comment: 12 pages + tables, 7 figures. Accepted for publication in Astronomy & Astrophysics
Published: 2016

44. An unusual case of adrenocortical carcinoma with liver metastasis that occurred at 23 years after surgery

Author: Luc Beuzit, Damien Bergeat, Karim Boudjema, Michel Rayar, Bernard Meunier, Aude Merdrignac, Julien Dagher, Giovanni Battista Levi Sandri, Laetitia Tanguy, Laurent Sulpice, Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], CHU Pontchaillou [Rennes], Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de Cytogénétique et de Biologie Cellulaire, Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Jonchère, Laurent, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes]
Subjects: 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Case Report, [SDV.CAN]Life Sciences [q-bio]/Cancer, Metastasis, Hemangioma, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, medicine, Adrenocortical carcinoma, Pathological, Lymph node, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Unusual case, Liver resection, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, Nephrectomy, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, 3. Good health, Surgery, Adrenocortical carcinoma (ACC), liver metastasis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Lymphadenectomy, business
Abstract: International audience; Adrenocortical carcinoma (ACC) is an uncommon and aggressive cancer occurring more frequently in women; local or distant recurrences occur in 80% of cases, typically within 1 year after curative resection. Liver is the preferred metastatic site. Herein, we report the case of a unique liver metastasis from ACC occurring 23 years after the curative prior tumor surgery. A 45-year-old woman was operated in 1991 for adrenocortical stage II without microvascular involvement or capsular infiltration. At that time, no adjuvant treatment was indicated. The initial surgery consisted on a left adrenalectomy with contemporaneous left nephrectomy and regional lymphadenectomy. Five years after surgery, the patient was considered cured. However, 23 years later, the patient presented an atypical right subcostal pain. A 4 cm liver ACC metastasis involving the segment 4 and initially diagnosed as a hemangioma was discovered. A curative resection of the segment 4 was performed. Final pathological examination confirmed the diagnosis of ACC metastasis with a complete R0 resection; no lymph node metastases were observed. This case is the latest metachronous ACC metastasis ever reported in literature. To date, the patient is alive with no signs of recurrence after a post-surgical follow-up of 13 months
Published: 2016

45. SAXO: the extreme adaptive optics system of SPHERE (I) system overview and global laboratory performance

Author: Denis Perret, Kjetil Dohlen, Cyril Petit, Mark Downing, Hans Martin Schmid, Philippe Feautrier, Jean-François Sauvage, Dimitri Mawet, Anne Costille, David Mouillet, Julien Girard, Marcos Suarez, Arnaud Sevin, Bernardo Salasnich, Francois Wildi, Arthur Vigan, Ronald Roelfsema, Pierre Baudoz, Markus Kasper, Pascal Puget, Sylvain Rochat, Christian Soenke, Enrico Fedrigo, Thierry Fusco, Jared O'Neal, Andrea Baruffolo, Jean-Luc Beuzit, Emmanuel Hugot, ONERA - The French Aerospace Lab [Châtillon], ONERA, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory (ESO), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Institut de Planétologique et d'Astrophysique de Institut de Planétologique et d'Astrophysique de Grenoble, Institute of Astronomy [ETH Zürich], Department of Physics [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), NOVA-ASTRON, ONERA-Université Paris Saclay (COmUE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Genève = University of Geneva (UNIGE), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), ITA, FRA, DEU, NLD, and CHE
Subjects: IMAGERIE À HAUT CONTRASTE, OPTIQUE ADAPTATIVE, 7. Clean energy, 01 natural sciences, law.invention, 010309 optics, Telescope, law, Observatory, 0103 physical sciences, Adaptive optics, 010303 astronomy & astrophysics, Instrumentation, Coronagraph, Remote sensing, EXOPLANETE, Physics, Very Large Telescope, Mechanical Engineering, Strehl ratio, Astronomy and Astrophysics, H band, Exoplanet, Electronic, Optical and Magnetic Materials, Space and Planetary Science, Control and Systems Engineering, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Abstract: International audience; The direct imaging of exoplanet is a leading field of today’s astronomy. The photons coming from the planet carry precious information on the chemical composition of its atmosphere. The second-generation instrument, Spectro-Polarimetric High contrast Exoplanet Research (SPHERE), dedicated to detection, photometry and spectral characterization of Jovian-like planets, is now in operation on the European very large telescope. This instrument relies on an extreme adaptive optics (XAO) system to compensate for atmospheric turbulence as well as for internal errors with an unprecedented accuracy. We demonstrate the high level of performance reached by the SPHERE XAO system (SAXO) during the assembly integration and test (AIT) period. In order to fully characterize the instrument quality, two AIT periods have been mandatory. In the first phase at Observatoire de Paris, the performance of SAXO itself was assessed. In the second phase at IPAG Grenoble Observatory, the operation of SAXO in interaction with the overall instrument has been optimized. In addition to the first two phases, a final check has been performed after the reintegration of the instrument at Paranal Observatory, in the New Integration Hall before integration at the telescope focus. The final performance aimed by the SPHERE instrument with the help of SAXO is among the highest Strehl ratio pretended for an operational instrument (90% in H band, 43% in V band in a realistic turbulence r0, and wind speed condition), a limit R magnitude for loop closure at 15, and a robustness to high wind speeds. The full-width at half-maximum reached by the instrument is 40 mas for infrared in H band and unprecedented 18.5 mas in V band.; L'imagerie directe d'exoplanètes est un domaine phare de l'astronomie actuelle. Les photons issus de la planète sont porteurs d'une information précieuse sur la composition chimique de son atmosphère. L'instrument de seconde génération SPHERE, Spectro-Polarimetri High-contrast Exoplanet Research, dédié à la détection la photométrie et la caractérisation spectrale de planètes joviennes, est maintenant en opération sur le très grand télescope Européen (VLT). Cet instrument repose sur une optique adaptative à très hautes performances (XAO) pour compenser les turbulences atmosphériques, comme les défauts optiques internes de l'instrument lui-même. Nous démontrons les très hauts niveaux de performance atteint par l'instrument SPHERE et son système de XAO SAXO, pendant la phase d'intégration (AIT). Pour pleinement caractériser les performances de l'instrument, deux périodes d'AIT ont été obligatoires. Dans la première phase à l'Observatoire de Paris, les performances de l'optique adaptative seule ont été obtenues. Dans la seconde phase à l'observatoire de Grenoble, l'opération de SAXO en interaction avec le reste de l'instrument ont été optimisées. En sus, une vérification finale a été faite au foyer du télescope. Les performances atteintes par SPHERE avec l'aide de SAXO sont parmi les plus hauts rapports de Strehl jamais atteint pour un instrument opérationnel (90% en bande H, 43% en bande V, sous hypothèse de turbulence et de vent classiques), et surtout une magnitude limite de R=15. La FHWM (largeur à mi-hauteur, la résolution de l'instrument) atteinte en bande H est de 40mas, et atteint une valeur sans précédent de 18.5mas en bande V.
Published: 2016

46. Comparison of Choi criteria and Response Evaluation Criteria in Solid Tumors (RECIST) for intrahepatic cholangiocarcinoma treated with glass-microspheres Yttrium-90 selective internal radiation therapy (SIRT)

Author: Vanessa Brun, Anne Guillygomarc'h, Yan Rolland, Yves Gandon, Luc Beuzit, Julien Edeline, Karim Boudjema, Etienne Garin, Maxime Ronot, Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Foie, métabolismes et cancer, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Département d'oncologie médicale [Rennes], CRLCC Eugène Marquis (CRLCC), Service de Pathologie [Clichy], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hépato-gastro-entérologie [Rennes] = Gastroenterology [Rennes], CHU Pontchaillou [Rennes], Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], Jonchère, Laurent, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, hepatocellular-carcinoma, Brachytherapy, Gastroenterology, 030218 nuclear medicine & medical imaging, Cholangiocarcinoma, 0302 clinical medicine, Choi Criteria, Yttrium Radioisotopes, european association, Intrahepatic Cholangiocarcinoma, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Aged, 80 and over, Selective internal radiation therapy, General Medicine, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Middle Aged, Microspheres, Treatment Outcome, Response Evaluation Criteria in Solid Tumors, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, Radiology, management, ct, radioembolization, safety, Adult, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, liver, survival, gastrointestinal stromal tumors, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Objective response, Aged, Retrospective Studies, business.industry, medicine.disease, Survival Analysis, Confidence interval, Bile Duct Neoplasms, business, Tomography, X-Ray Computed, Progressive disease
Abstract: International audience; Objective: To compare Choi criteria with Response Evaluation Criteria in Solid Tumors (RECIST) for the prediction of overall survival (OS) in patients treated with glass-microspheres, Yttrium-90 selective internal radiation therapy (SIRT) for intrahepatic cholangiocarcinoma (ICC). Methods: Between 2010 and 2014, 45 adult patients with locally advanced ICC treated with SIRT were retrospectively analyzed. Computed tomography scans performed before and after treatment were analyzed using both RECIST 1.1 and Choi criteria. Response was correlated with survival. Results: Patients who achieved an objective response according to Choi had a longer OS than non responders (median OS 19.9 months [95% CI, 1.1-38.7 months] vs. 7.5 months if stable disease [uncountable CI] and 3 months if progressive disease [95% CI, 0-6.2 months], log-rank test: p = 0.003) whereas there was no significant survival difference according to the RECIST response (p = 0.339). Among the 39 RECIST non-responding patients, those identified as responders by Choi (n = 31) had significantly better OS than Choi non-responders (median OS 19.9 months (95% CI, 5.1-34.7 months) and 5.4 months (95% CI, 0-11.6 months), p = 0.005). Conclusions: Choi criteria appear more appropriate than RECIST to identify responders with long survival among patients who received SIRT for ICC. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Published: 2016

47. First light of the VLT planet finder SPHERE. II. The physical properties and the architecture of the young systems PZ Telescopii and HD 1160 revisited

Author: Th. Henning, Emmanuel Hugot, Cyril Petit, Julien Milli, Massimo Turatto, Dimitri Mawet, Silvano Desidera, M. Kasper, O. Möller-Nilsson, Stéphane Udry, Alice Zurlo, A. Pavlov, Enrico Giro, Cecile Gry, M. Millward, Andrea Baruffolo, David Ehrenreich, Sergio Messina, Enrico Cascone, Jean-Luc Beuzit, M. Llored, T. Kopytova, Zahed Wahhaj, Andreas Bazzon, P. Martinez, Norbert Hubin, C. Moutou, Mickael Bonnefoy, Thibaut Moulin, Raffaele Gratton, Kjetil Dohlen, P. Blanchard, L. Weber, S. Rochat, Ch. Ginski, Riccardo Claudi, Pascal Puget, Anne Costille, Alain Origne, M. Carle, D. Le Mignant, Gael Chauvin, David Mouillet, H. M. Schmid, A. Delboulbe, M. Feldt, Anthony Boccaletti, Raphaël Galicher, Arthur Vigan, J. Pragt, D. Gisler, C. Thalmann, Jacopo Antichi, L. Gluck, Jose Ramos, J. de Boer, Anne-Marie Lagrange, Anne-Lise Maire, Ronald Roelfsema, Thierry Fusco, Julien Girard, Farrokh Vakili, Dino Mesa, Bernardo Salasnich, Maud Langlois, V. De Caprio, M. Jaquet, Carsten Dominik, Jean-François Sauvage, Francois Wildi, F. Madec, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), INAF - Osservatorio Astrofisico di Catania (OACT), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Institute for Astronomy [Zürich], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Geneva Observatory, University of Geneva [Switzerland], Universidad Diego Portales [Santiago] (UDP), Departamento de Astronomia (DAS), Universidad de Santiago de Chile [Santiago] (USACH), Laboratoire d'Astrophysique de Grenoble (LAOG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Euratom/UKAEA Fusion Assoc., Culham Science Centre [Abingdon], Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), ONERA - The French Aerospace Lab [Châtillon], ONERA, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), ESO, Physics Department [Garching], Technical University of Munich (TUM)-Technical University of Munich (TUM), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), UMR 5805 Environnements et Paléoenvironnements Océaniques et Continentaux (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Caltech Department of Astronomy [Pasadena], California Institute of Technology (CALTECH), Canada-France-Hawaii Telescope Corporation, NASA Goddard Space Flight Center (GSFC), De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies (MONARIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Universiteit Leiden, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Université de Genève = University of Geneva (UNIGE), ONERA-Université Paris Saclay (COmUE), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Environnements et Paléoenvironnements OCéaniques (EPOC), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Canada-France-Hawaii Telescope Corporation (CFHT), National Research Council of Canada (NRC)-Centre National de la Recherche Scientifique (CNRS)-University of Hawai'i [Honolulu] (UH), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and Low Energy Astrophysics (API, FNWI)
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Physics, Very Large Telescope, 010308 nuclear & particles physics, Metallicity, Brown dwarf, FOS: Physical sciences, Astronomy and Astrophysics, Context (language use), Astrophysics, 01 natural sciences, Exoplanet, Luminosity, Photometry (optics), Space and Planetary Science, 0103 physical sciences, Spectral energy distribution, Astrophysics - Instrumentation and Methods for Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: [Abridged] Context. The young systems PZ Tel and HD 1160, hosting known low-mass companions, were observed during the commissioning of the new planet finder SPHERE with several imaging and spectroscopic modes. Aims. We aim to refine the physical properties and architecture of both systems. Methods. We use SPHERE commissioning data and REM observations, as well as literature and unpublished data from VLT/SINFONI, VLT/NaCo, Gemini/NICI, and Keck/NIRC2. Results. We derive new photometry and confirm the nearly daily photometric variability of PZ Tel A. Using literature data spanning 38 yr, we show that the star also exhibits a long-term variability trend. The 0.63-3.8 mic SED of PZ Tel B allows us to revise its properties: spectral type M7+/-1, Teff=2700+/-100 K, log(g)0.66) of PZ Tel B. For e4 MJ) outside 0.5" for the PZ Tel system. We also show that K1-K2 color can be used with YJH low-resolution spectra to identify young L-type companions, provided high photometric accuracy (, 25 pages, 23 figures, accepted for publication in A&A on Oct. 13th, 2015; version including language editing. Typo on co-author name on astroph page corrected, manuscript unchanged
Published: 2016

48. Sparse aperture masking with SPHERE

Author: Jean-Luc Beuzit, Xavier Haubois, Guillaume Schworer, Sylvestre Lacour, Julien Girard, Anthony Cheetham, Univ. de Geneve (Switzerland), European Southern Observatory (Chile), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Haute résolution angulaire en astrophysique, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Subjects: Masking (art), Diffraction, Physics, business.industry, Aperture, Conjunction (astronomy), Near-infrared spectroscopy, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 010309 optics, Interferometry, Optics, 0103 physical sciences, Multi-band device, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], business, Adaptive optics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics
Abstract: International audience; Sparse Aperture Masking (SAM) has recently been commissioned on SPHERE, the VLTs new adaptive optics high resolution imager. SAM extends the capabilities of SPHERE by providing high contrast measurements at and beyond the traditional diffraction limit. SAM can be used in conjunction with each of the SPHERE modules (IRDIS, IFS and ZIMPOL), allowing dual band imaging in the visible and near-infrared, near-infrared integral field spectroscopy, and polarized differential imaging in the visible and near-infrared. In this paper we report information relevant for observers as well as some commissioning observations.
Published: 2016
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49. Évaluation multiparamétrique par TEP choline et IRM dans le cancer de prostate

Author: Patrick Bourguet, Luc Beuzit, Solène Querellou, Eduardo H. Garin, A.L. Blin, Anne Devillers, H. Saint Jalmes, F. Le Jeune, Xavier Palard, and Pierre-Yves Salaun
Subjects: Radiological and Ultrasound Technology, Biophysics, Radiology, Nuclear Medicine and imaging
Abstract: Objectifs Rechercher une eventuelle correlation entre les parametres metaboliques obtenus par TEP choline et les parametres de diffusion et de perfusion obtenus par IRM dans le cancer de prostate. Materiels et methodes Les patients ayant un cancer de prostate prouve venant pour bilan initial ou de recidive ayant une TEP choline et une IRM ont ete prospectivement inclus. L’examen TEP choline etait compose d’une acquisition pelvienne precoce en list-mode (0–10 min) et d’une acquisition tardive corps entier a 60 minutes. Une serie statique d’une image de 10 minutes et une serie dynamique de 12 × 5″ puis 3 × 30″ des 150 premieres secondes du list-mode etaient reconstruites. Un volume d’interet (VOI) avec un seuil a 40 % etait dessine sur l’acquisition tardive et projete dans l’acquisition statique precoce et dans chaque trame de la dynamique. Le parametre dynamique representant l’influx (K1) et les parametres statiques (SUVmoyen precoce, SUVmoyen tardif et index de retention) etaient extraits. Concernant l’examen IRM (1,5 T), apres recalage de la diffusion avec l’acquisition TEP tardive, une VOI etait dessinee sur l’IRM de diffusion et projetee sur les cartographies de perfusion. Le coefficient apparent de diffusion (ADC), la constante de transfert du gadolinium (ktrans) et le volume extra-cellulaire de gadolinium (Ve) etaient extraits. Une eventuelle correlation entre tous ces parametres etait testee par la correlation de Spearman. Resultats Treize patients etaient analyses avec 11 lesions intra-prostatiques et 2 lesions du lit de prostatectomie. Neuf patients venaient dans le cadre d’une recidive et 4 patients en initial. Le delai entre la TEP Choline etait en moyenne de 39 jours. Concernant les parametres TEP, il existait une correlation statistiquement significative entre K1 et le SUVmoyen precoce (r = 0,61 ; p = 0,026) et entre SUVmoyen precoce et tardif (r = 0,85 ; p Conclusion L’influx de choline mesure en TEP choline semble correle a la constante de transfert du gadolinium mesuree en IRM dans le cancer de prostate.
Published: 2018

50. Characterization of the Twa22 AB system. A new calibrator for evolutionary tracks?

Author: Inseok Song, Gael Chauvin, M. Bonnefoy, Ben Zuckerman, Jean-Luc Beuzit, F. Allard, Anne-Marie Lagrange, Christophe Dumas, and H. Beust
Subjects: Physics, General Engineering, Brown dwarf, Binary number, Astronomy, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, System a, Stars, Space and Planetary Science, Astrophysics::Solar and Stellar Astrophysics, TW Hydrae, Astrophysics::Earth and Planetary Astrophysics, Astrophysics::Galaxy Astrophysics
Abstract: Tight binaries discovered in young nearby associations are ideal targets to provide dynamical mass measurments through orbital monitoring. Coupled with estimated temperatures, surface gravities and luminosities, direct mass measurments provide benchmarks for evolutionary models of low-mass stars ( M ≤ 0.5 M ๏ ) and brown dwarfs ( M ≤ 0.078 M ๏ ) at young ages (Age ≤ 100 Myrs). TWA22 AB is likely to be a member of the nearby TW Hydrae association (Age ~ 8 Myr). It was resolved in a tigh binary with a projected separation of a few AU. In this paper we present preliminary results on the companion orbital monitoring and on the spectral characterisation of the system.
Published: 2010

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