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5 results on '"Lucía Reviglio A"'

2. Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems

Author

Luciana Fernández, Ana Lucía Reviglio, Daniel A. Heredia, Gustavo M. Morales, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, Enrique L. Larghi, Andrea B.J. Bracca, and Teodoro S. Kaufman

Subjects
Langmuir monolayers, Drug-carrier composites, Cell culture, Triclisine, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures.

Published
2021
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3. Novel Cocrystals and Eutectics of the Antiprotozoal Tinidazole: Mechanochemical Synthesis, Cocrystallization, and Characterization

Author

Mino R. Caira, Norma R. Sperandeo, Sonia Nerina Faudone, Octavio E. Fandiño, Gustavo A. Monti, Yamila Garro Linck, Marina M. Marcos Valdez, and Lucía Reviglio

Subjects
Materials science, 010405 organic chemistry, medicine.drug_class, General Chemistry, 010402 general chemistry, Condensed Matter Physics, 01 natural sciences, Tinidazole, 0104 chemical sciences, Characterization (materials science), Solid-state nuclear magnetic resonance, Mechanochemistry, X-ray crystallography, Aqueous solubility, medicine, Antiprotozoal, General Materials Science, medicine.drug, Nuclear chemistry, Eutectic system
Abstract

Antiprotozoal tinidazole (TNZ) exhibits low aqueous solubility (Sw) and poor photochemical stability. In this work, TNZ was used to form cocrystals and eutectics with the aim of enhancing its solub...

Published
2020

4. Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems

Author

Luis Otero, Enrique L. Larghi, Fabrisio Alustiza, Gustavo M. Morales, Teodoro S. Kaufman, Daniel Alejandro Heredia, Pablo Bosch, Andrea B. J. Bracca, Ana Lucía Reviglio, Marisa Santo, Luciana Fernandez, and Ana Cecilia Liaudat

Subjects
0301 basic medicine, LANGMUIR MONOLAYERS, Langmuir, Langmuir–Blodgett film, Transportadores de Fármacos, purl.org/becyt/ford/1 [https], 03 medical and health sciences, 0302 clinical medicine, DRUG-CARRIER COMPOSITES, Drug Delivery Systems, Amphiphile, Monolayer, purl.org/becyt/ford/1.4 [https], Bioactive Compounds, lcsh:Social sciences (General), lcsh:Science (General), Langmuir monolayers, Compuestos Bioactivos, Drug Carriers, Multidisciplinary, Nanocomposite, Cultivo de Células, Chemistry, Cell Culture, technology, industry, and agriculture, Sistemas de Administración de Drogas, Triclisine, 030104 developmental biology, Cell culture, Drug delivery, Biophysics, TRICLISINE, lcsh:H1-99, lipids (amino acids, peptides, and proteins), Drug-carrier composites, Wound healing, 030217 neurology & neurosurgery, lcsh:Q1-390, Research Article
Abstract

Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures., Langmuir monolayers, Drug-carrier composites, Cell culture, Triclisine

Published
2021

5. Formation and characterization of Langmuir and Langmuir-Blodgett films of Newkome-type dendrons in presence and absence of a therapeutic compound, for the development of surface mediated drug delivery systems

Author

Marisa Martinelli, Marisa Santo, Fabrisio Alustiza, Luis Otero, Luciana Fernandez, Ana Cecilia Liaudat, Nahir Dib, Marcelo Calderón, Pablo Bosch, Ana Lucía Reviglio, Miriam Cristina Strumia, and Gustavo M. Morales

Subjects
LANGMUIR MONOLAYERS, Dendrimers, Langmuir, Biocompatibility, CELL CULTURE, Surface Properties, Antineoplastic Agents, Biocompatible Materials, Nanotechnology, 02 engineering and technology, DRUG-CARRIERS COMPOSITES, Albendazole, Microscopy, Atomic Force, 010402 general chemistry, 01 natural sciences, Langmuir–Blodgett film, DENDRONS, Biomaterials, Mice, Structure-Activity Relationship, Colloid and Surface Chemistry, Dendrimer, Monolayer, Cell Adhesion, Animals, Humans, Nitrobenzenes, Cell Proliferation, Drug Carriers, Aniline Compounds, Chemistry, Otras Ciencias Químicas, Ciencias Químicas, 021001 nanoscience & nanotechnology, Nanostructures, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Drug delivery, NIH 3T3 Cells, Nanocarriers, 0210 nano-technology, Drug carrier, CIENCIAS NATURALES Y EXACTAS
Abstract

Organic macromolecules with dendrimeric architectures are polymeric materials potentially useful as nanocarriers for therapeutic drugs. In this work, we evaluate a series of Newkome-type dendrons in Langmuir and Langmuir-Blodgett films as platforms capable of interacting with a potential antitumoral agent. The nanocomposite is proposed as model for the development of surface mediated drug delivery systems. We were successful in the formation and characterization of pure (dendrons) and composite (drug-dendron) stable and reproducible monolayers, and their transfer to solid substrates. A detailed study of topographic characteristics of the generated surfaces by atomic force microscopy was conducted. Furthermore, we probed dendron monolayer films as anchorage surfaces for mammalian cells. Normal cell attachment and proliferation on the surfaces were observed. No evident cytotoxic effects were detected, demonstrating the adequate biocompatibility of the surfaces. Fil: Dib, Nahir. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Reviglio, Ana Lucía. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Fernández, Luciana. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Morales, Gustavo. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Santo, Marisa Rosana. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Otero, Luis Alberto. Universidad Nacional de Rio Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química y Física; Argentina Fil: Alustiza, Fabrisio Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina Fil: Liaudat, Ana Cecilia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina Fil: Bosch, Pablo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina Fil: Calderon, Marcelo. Universität zu Berlin; Alemania. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina Fil: Martinelli, Marisa. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina

Published
2017

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