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1. Oncology and mechanics: landmark studies and promising clinical applications

Author

Urcun, Stéphane, Lorenzo, Guillermo, Baroli, Davide, Rohan, Pierre-Yves, Sciumè, Giuseppe, Skalli, Wafa, Lubrano, Vincent, and Bordas, Stéphane P. A.

Subjects
Quantitative Biology - Tissues and Organs, Computer Science - Computational Engineering, Finance, and Science, Quantitative Biology - Cell Behavior
Abstract

Clinical management of cancer has continuously evolved for several decades. Biochemical, molecular and genomics approaches have brought and still bring numerous insights into cancerous diseases. It is now accepted that some phenomena, allowed by favorable biological conditions, emerge via mechanical signaling at the cellular scale and via mechanical forces at the macroscale. Mechanical phenomena in cancer have been studied in-depth over the last decades, and their clinical applications are starting to be understood. If numerous models and experimental setups have been proposed, only a few have led to clinical applications. The objective of this contribution is to propose to review a large scope of mechanical findings which have consequences on the clinical management of cancer. This review is mainly addressed to doctoral candidates in mechanics and applied mathematics who are faced with the challenge of the mechanics-based modeling of cancer with the aim of clinical applications. We show that the collaboration of the biological and mechanical approaches has led to promising advances in terms of modeling, experimental design and therapeutic targets. Additionally, a specific focus is brought on imaging-informed mechanics-based models, which we believe can further the development of new therapeutic targets and the advent of personalized medicine. We study in detail several successful workflows on patient-specific targeted therapies based on mechanistic modeling.

Published
2022
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2. PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors

Author

Tauziède-Espariat, Arnault, Siegfried, Aurore, Nicaise, Yvan, Dghayem, Delphine, Laprie, Anne, Lubrano, Vincent, Richard, Pomone, Gauchotte, Guillaume, Malczuk, Joséphine, Klein, Olivier, Hasty, Lauren, Métais, Alice, Chrétien, Fabrice, Dangouloff-Ros, Volodia, Boddaert, Nathalie, Sahm, Felix, Sievers, Philipp, Varlet, Pascale, and Uro-Coste, Emmanuelle

Published
2023
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6. Natural Course and Prognosis of Primary Spinal Glioblastoma: A Nationwide Study

Author

Amelot, Aymeric, Terrier, Louis-Marie, Mathon, Bertrand, Joubert, Christophe, Picart, Thiebaud, Jecko, Vincent, Bauchet, Luc, Benard, Florian, Castel, Xavier, Chenin, Louis, Cook, Ann-Rose, Emery, Evelyne, Figarella-Branger, Dominique, Gauchotte, Guillaume, Graillon, Thomas, Jouvet, Anne, Kalamarides, Michel, Knafo, Steven, Lazard, Arnaud, Lubrano, Vincent, Mokhtari, Karima, Rigau, Valérie, Roualdes, Vincent, Rousseau, Audrey, Seizeur, Romuald, Uro-Coste, Emmanuelle, Voirin, Jimmy, Metellus, Philippe, Pallud, Johan, and Zemmoura, Ilyess

Published
2023
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9. The STEMRI trial: Magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma stem-like cells

Author

Lemarié, Anthony, primary, Lubrano, Vincent, additional, Delmas, Caroline, additional, Lusque, Amélie, additional, Cerapio, Juan-Pablo, additional, Perrier, Marion, additional, Siegfried, Aurore, additional, Arnauduc, Florent, additional, Nicaise, Yvan, additional, Dahan, Perrine, additional, Filleron, Thomas, additional, Mounier, Muriel, additional, Toulas, Christine, additional, and Cohen-Jonathan Moyal, Elizabeth, additional

Published
2023
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10. 3D Real-Time Collaborative Environment to Learn Teamwork and Non-technical Skills in the Operating Room

Author

Lelardeux, Catherine Pons, Panzoli, David, Galaup, Michel, Minville, Vincent, Lubrano, Vincent, Lagarrigue, Pierre, Jessel, Jean-Pierre, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Auer, Michael E., editor, Guralnick, David, editor, and Uhomoibhi, James, editor

Published
2017
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14. Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging

Author

Freyschlag, Christian F., Krieg, Sandro M., Kerschbaumer, Johannes, Pinggera, Daniel, Forster, Marie-Therese, Cordier, Dominik, Rossi, Marco, Miceli, Gabriele, Roux, Alexandre, Reyes, Andrés, Sarubbo, Silvio, Smits, Anja, Sierpowska, Joanna, Robe, Pierre A., Rutten, Geert-Jan, Santarius, Thomas, Matys, Tomasz, Zanello, Marc, Almairac, Fabien, Mondot, Lydiane, Jakola, Asgeir S., Zetterling, Maria, Rofes, Adrià, von Campe, Gord, Guillevin, Remy, Bagatto, Daniele, Lubrano, Vincent, Rapp, Marion, Goodden, John, De Witt Hamer, Philip C., Pallud, Johan, Bello, Lorenzo, Thomé, Claudius, Duffau, Hugues, and Mandonnet, Emmanuel

Published
2018
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15. Supplementary Data from Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells

Author

Malric, Laure, primary, Monferran, Sylvie, primary, Delmas, Caroline, primary, Arnauduc, Florent, primary, Dahan, Perrine, primary, Boyrie, Sabrina, primary, Deshors, Pauline, primary, Lubrano, Vincent, primary, Da Mota, Dina Ferreira, primary, Gilhodes, Julia, primary, Filleron, Thomas, primary, Siegfried, Aurore, primary, Evrard, Solène, primary, Kowalski-Chauvel, Aline, primary, Moyal, Elizabeth Cohen-Jonathan, primary, Toulas, Christine, primary, and Lemarié, Anthony, primary

Published
2023
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16. Supplementary Figures 1-5 from Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells

Author

Malric, Laure, primary, Monferran, Sylvie, primary, Delmas, Caroline, primary, Arnauduc, Florent, primary, Dahan, Perrine, primary, Boyrie, Sabrina, primary, Deshors, Pauline, primary, Lubrano, Vincent, primary, Da Mota, Dina Ferreira, primary, Gilhodes, Julia, primary, Filleron, Thomas, primary, Siegfried, Aurore, primary, Evrard, Solène, primary, Kowalski-Chauvel, Aline, primary, Moyal, Elizabeth Cohen-Jonathan, primary, Toulas, Christine, primary, and Lemarié, Anthony, primary

Published
2023
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17. Data from Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells

Author

Malric, Laure, primary, Monferran, Sylvie, primary, Delmas, Caroline, primary, Arnauduc, Florent, primary, Dahan, Perrine, primary, Boyrie, Sabrina, primary, Deshors, Pauline, primary, Lubrano, Vincent, primary, Da Mota, Dina Ferreira, primary, Gilhodes, Julia, primary, Filleron, Thomas, primary, Siegfried, Aurore, primary, Evrard, Solène, primary, Kowalski-Chauvel, Aline, primary, Moyal, Elizabeth Cohen-Jonathan, primary, Toulas, Christine, primary, and Lemarié, Anthony, primary

Published
2023
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18. Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging

Author

Laprie, Anne, Ken, Soléakhéna, Filleron, Thomas, Lubrano, Vincent, Vieillevigne, Laure, Tensaouti, Fatima, Catalaa, Isabelle, Boetto, Sergio, Khalifa, Jonathan, Attal, Justine, Peyraga, Guillaume, Gomez-Roca, Carlos, Uro-Coste, Emmanuelle, Noel, Georges, Truc, Gilles, Sunyach, Marie-Pierre, Magné, Nicolas, Charissoux, Marie, Supiot, Stéphane, Bernier, Valérie, Mounier, Muriel, Poublanc, Muriel, Fabre, Amandine, Delord, Jean-Pierre, and Cohen-Jonathan Moyal, Elizabeth

Published
2019
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19. The STEMRI trial: magnetic resonance spectroscopy imaging can define tumor areas enriched in glioblastoma-initiating cells

Author

Lemarié, Anthony, primary, Lubrano, Vincent, additional, Delmas, Caroline, additional, Lusque, Amélie, additional, Cerapio, Juan-Pablo, additional, Perrier, Marion, additional, Siegfried, Aurore, additional, Arnauduc, Florent, additional, Nicaise, Yvan, additional, Dahan, Perrine, additional, Filleron, Thomas, additional, Mounier, Muriel, additional, Toulas, Christine, additional, and Moyal, Elizabeth Cohen-Jonathan, additional

Published
2023
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24. Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol

Author

Rofes, Adrià, Mandonnet, Emmanuel, Godden, John, Baron, Marie Hélène, Colle, Henry, Darlix, Amelie, de Aguiar, Vânia, Duffau, Hugues, Herbet, Guillaume, Klein, Martin, Lubrano, Vincent, Martino, Juan, Mathew, Ryan, Miceli, Gabriele, Moritz-Gasser, Sylvie, Pallud, Johan, Papagno, Costanza, Rech, Fabien, Robert, Erik, Rutten, Geert-Jan, Santarius, Thomas, Satoer, Djaina, Sierpowska, Joanna, Smits, Anja, Skrap, Miran, Spena, Giannantonio, Visch, Evy, De Witte, Elke, Zetterling, Maria, and Wager, Michel

Published
2017
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26. Evaluation of the Lactate-to-N-Acetyl-aspartate Ratio Defined With Magnetic Resonance Spectroscopic Imaging Before Radiation Therapy as a New Predictive Marker of the Site of Relapse in Patients With Glioblastoma Multiforme

Author

Deviers, Alexandra, Ken, Soléakhéna, Filleron, Thomas, Rowland, Benjamin, Laruelo, Andrea, Catalaa, Isabelle, Lubrano, Vincent, Celsis, Pierre, Berry, Isabelle, Mogicato, Giovanni, Cohen-Jonathan Moyal, Elizabeth, and Laprie, Anne

Published
2014
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31. Quality control of 3D MRSI data in glioblastoma: Can we do without the experts?

Author

Tensaouti, Fatima, primary, Desmoulin, Franck, additional, Gilhodes, Julia, additional, Martin, Elodie, additional, Ken, Soleakhena, additional, Lotterie, Jean‐Albert, additional, Noël, Georges, additional, Truc, Gilles, additional, Sunyach, Marie‐Pierre, additional, Charissoux, Marie, additional, Magné, Nicolas, additional, Lubrano, Vincent, additional, Péran, Patrice, additional, Cohen‐Jonathan Moyal, Elizabeth, additional, and Laprie, Anne, additional

Published
2021
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36. Quality control of 3D MRSI data in glioblastoma: Can we do without the experts?

Author

Tensaouti, Fatima, Desmoulin, Franck, Gilhodes, Julia, Martin, Elodie, Ken, Soleakhena, Lotterie, Jean‐Albert, Noël, Georges, Truc, Gilles, Sunyach, Marie‐Pierre, Charissoux, Marie, Magné, Nicolas, Lubrano, Vincent, Péran, Patrice, Cohen‐Jonathan Moyal, Elizabeth, and Laprie, Anne

Subjects
QUALITY control, PROTON magnetic resonance, GLIOBLASTOMA multiforme, FEATURE extraction, MAGNETIC resonance imaging
Abstract

Purpose: Proton magnetic resonance spectroscopic imaging (1H MRSI) is a noninvasive technique for assessing tumor metabolism. Manual inspection is still the gold standard for quality control (QC) of spectra, but it is both time‐consuming and subjective. The aim of the present study was to assess automatic QC of glioblastoma MRSI data using random forest analysis. Methods: Data for 25 patients, acquired prospectively in a preradiotherapy examination, were submitted to postprocessing with syngo.MR Spectro (VB40A; Siemens) or Java‐based magnetic resonance user interface (jMRUI) software. A total of 28 features were extracted from each spectrum for the automatic QC. Three spectroscopists also performed manual inspections, labeling each spectrum as good or poor quality. All statistical analyses, with addressing unbalanced data, were conducted with R 3.6.1 (R Foundation for Statistical Computing; https://www.r‐project.org). Results: The random forest method classified the spectra with an area under the curve of 95.5%, sensitivity of 95.8%, and specificity of 81.7%. The most important feature for the classification was Residuum_Lipids_Versus_Fit, obtained with syngo.MR Spectro. Conclusion: The automatic QC method was able to distinguish between good‐ and poor‐quality spectra, and can be used by radiation oncologists who are not spectroscopy experts. This study revealed a novel set of MRSI signal features that are closely correlated with spectral quality. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma

Author

Benouaich-Amiel, Alexandra, Lubrano, Vincent, Tafani, Mathieu, Uro-coste, Emmanuelle, Gantet, Pierre, Sol, Jean Christophe, Roux, Franck, Bousquet, Philippe, Julian, Anne, Sabatier, Jean, Tremoulet, Michel, Cances-Lauwers, Valerie, Delisle, Marie Bernadette, Clanet, Michel, Esquerré, Jean Philippe, and Payoux, Pierre

Published
2010

39. Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost

Author

Ken Soléakhéna, Vieillevigne Laure, Franceries Xavier, Simon Luc, Supper Caroline, Lotterie Jean-Albert, Filleron Thomas, Lubrano Vincent, Berry Isabelle, Cassol Emmanuelle, Delannes Martine, Celsis Pierre, Cohen-Jonathan Elizabeth Moyal, and Laprie Anne

Subjects
MR spectroscopy imaging (MRSI), Glioblastoma, Simultaneous integrated boost intensity modulation radiation therapy (SIB-IMRT),Dose painting, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). Methods For sixteen glioblastoma patients, we have simulated three types of dosimetry plans, one conventional plan of 60-Gy in 3D conformational radiotherapy (3D-CRT), one 60-Gy plan in IMRT and one 72-Gy plan in SIB-IMRT. All sixteen MRSI metabolic maps were integrated into TPS, using normalization with color-space conversion and threshold-based segmentation. The fusion between the metabolic maps and the planning CT scans were assessed. Dosimetry comparisons were performed between the different plans of 60-Gy 3D-CRT, 60-Gy IMRT and 72-Gy SIB-IMRT, the last plan was targeted on MRSI abnormalities and contrast enhancement (CE). Results Fusion assessment was performed for 160 transformations. It resulted in maximum differences p Conclusions Delivering standard doses to conventional target and higher doses to new target volumes characterized by MRSI and CE is now possible and does not increase dose to organs at risk. MRSI and CE abnormalities are now integrated for glioblastoma SIB-IMRT, concomitant with temozolomide, in an ongoing multi-institutional phase-III clinical trial. Our method of MR spectroscopy maps integration to TPS is robust and reliable; integration to neuronavigation systems with this method could also improve glioblastoma resection or guide biopsies.

Published
2013
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40. RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma

Author

Boyrie, Sabrina, Delmas, Caroline, Lemarié, Anthony, Lubrano, Vincent, Dahan, Perrine, Malric, Laure, Luis, José, Gilhodes, Julia, Tosolini, Marie, Mouly, Laetitia, Lehmann, Maxime, Toulas, Christine, Cohen-Jonathan Moyal, Elizabeth, Monferran, Sylvie, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Neurochirurgie [CHU Toulouse], Pôle Neurosciences [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Claudius Regaud, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biophotonique et Pharmacologie - UMR 7213 (LBP), Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Institut Claudius Regaud, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurochirurgie, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Université Fédérale Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)

Subjects
endocrine system, glioblastoma stem-like cells, [SDV]Life Sciences [q-bio], periventricular zone, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.CAN]Life Sciences [q-bio]/Cancer, RND1, prognostic signature, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, migration, Research Paper
Abstract

International audience; Despite post-operative radio-chemotherapy, glioblastoma systematically locally recurs. Tumors contacting the periventricular zone (PVZ) show earlier and more distant relapses than tumors not contacting the PVZ. Since glioblastoma stem-like cells (GSCs) have been proposed to play a major role in glioblastoma recurrence, we decided to test whether GSC migration properties could be different according to their anatomical location (PVZ+/PVZ-). For that purpose, we established paired cultures of GSCs from the cortical area (CT) and the PVZ of glioblastoma patient tumors. We demonstrated that PVZ GSCs possess higher migration and invasion capacities than CT GSCs. We highlighted specific transcriptomic profiles in PVZ versus CT populations and identified a down-regulation of the RhoGTPase, RND1 in PVZ GSCs compared to CT GSCs. Overexpression of RND1, dramatically inhibited PVZ GSC migration and conversely, downregulation of RND1 increased CT GSC migration. Additionally, transcriptomic analyses also revealed a down-regulation of RND1 in glioblastoma compared to normal brain. Using the glioblastoma TCGA database, low levels of RND1 were also shown to correlate with a decreased overall survival of patients. Finally, based on signaling pathways activated in patients with low levels of RND1, we identified an RND1 low signature of six genes (MET, LAMC1, ITGA5, COL5A1, COL3A1, COL1A2) that is an independent prognostic factor in glioblastoma. These findings contribute to explain the shorter time to progression of patients with PVZ involvement and, point out genes that establish the RND1 low signature as key targets genes to impede tumor relapse after treatment.

Published
2018

41. Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-Initiating Cells

Author

Malric, Laure, primary, Monferran, Sylvie, additional, Delmas, Caroline, additional, Arnauduc, Florent, additional, Dahan, Perrine, additional, Boyrie, Sabrina, additional, Deshors, Pauline, additional, Lubrano, Vincent, additional, Da Mota, Dina Ferreira, additional, Gilhodes, Julia, additional, Filleron, Thomas, additional, Siegfried, Aurore, additional, Evrard, Solène, additional, Kowalski-Chauvel, Aline, additional, Moyal, Elizabeth Cohen-Jonathan, additional, Toulas, Christine, additional, and Lemarié, Anthony, additional

Published
2019
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42. Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging.

Author

Freyschlag, Christian F, Krieg, Sandro M, Kerschbaumer, Johannes, Pinggera, Daniel, Forster, Marie-Therese, Cordier, Dominik, Rossi, Marco, Miceli, Gabriele, Roux, Alexandre, Reyes, Andrés, Sarubbo, Silvio, Smits, Anja, Sierpowska, Joanna, Robe, Pierre A, Rutten, Geert-Jan, Santarius, Thomas, Matys, Tomasz, Zanello, Marc, Almairac, Fabien, Mondot, Lydiane, Jakola, Asgeir S, Zetterling, Maria, Rofes, Adrià, von Campe, Gord, Guillevin, Remy, Bagatto, Daniele, Lubrano, Vincent, Rapp, Marion, Goodden, John, De Witt Hamer, Philip C, Pallud, Johan, Bello, Lorenzo, Thomé, Claudius, Duffau, Hugues, Mandonnet, Emmanuel, Freyschlag, Christian F, Krieg, Sandro M, Kerschbaumer, Johannes, Pinggera, Daniel, Forster, Marie-Therese, Cordier, Dominik, Rossi, Marco, Miceli, Gabriele, Roux, Alexandre, Reyes, Andrés, Sarubbo, Silvio, Smits, Anja, Sierpowska, Joanna, Robe, Pierre A, Rutten, Geert-Jan, Santarius, Thomas, Matys, Tomasz, Zanello, Marc, Almairac, Fabien, Mondot, Lydiane, Jakola, Asgeir S, Zetterling, Maria, Rofes, Adrià, von Campe, Gord, Guillevin, Remy, Bagatto, Daniele, Lubrano, Vincent, Rapp, Marion, Goodden, John, De Witt Hamer, Philip C, Pallud, Johan, Bello, Lorenzo, Thomé, Claudius, Duffau, Hugues, and Mandonnet, Emmanuel

Abstract

OBJECTIVE: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. METHODS: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery. RESULTS: A total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI. CONCLUSION: A minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of ≤ 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET. IMPORTANCE OF THE STUDY: We believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed "minimal core of imaging" in clinical routine will facilitate future cooperative studies.

Published
2018
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43. Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging

Author

Freyschlag, Christian Franz, Krieg, Sandro, Kerschbaumer, Johannes, Pinggera, Daniel, Forster, Marie-Thérèse, Cordier, Dominik, Rossi, Marco, Miceli, Gabriele, Roux, Alexandre, Reyes, Andrés, Sarubbo, Silvio, Smits, Anja, Sierpowska, Joanna, Robe, Pierre A., Rutten, Geert‑Jan, Santarius, Thomas, Matys, Tomasz, Zanello, Marc, Almairac, Fabien, Mondot, Lydiane, Jakola, Asgeir Store, Zetterling, Maria, Rofes, Adrià, Campe, Gord von, Guillevin, Remy, Bagatto, Daniele, Lubrano, Vincent, Rapp, Marion, Goodden, John, Witt Hamer, Philip C. de, Pallud, Johan, Bello, Lorenzo, Thomé, Claudius, Duffau, Hugues, Mandonnet, Emmanuel, Freyschlag, Christian Franz, Krieg, Sandro, Kerschbaumer, Johannes, Pinggera, Daniel, Forster, Marie-Thérèse, Cordier, Dominik, Rossi, Marco, Miceli, Gabriele, Roux, Alexandre, Reyes, Andrés, Sarubbo, Silvio, Smits, Anja, Sierpowska, Joanna, Robe, Pierre A., Rutten, Geert‑Jan, Santarius, Thomas, Matys, Tomasz, Zanello, Marc, Almairac, Fabien, Mondot, Lydiane, Jakola, Asgeir Store, Zetterling, Maria, Rofes, Adrià, Campe, Gord von, Guillevin, Remy, Bagatto, Daniele, Lubrano, Vincent, Rapp, Marion, Goodden, John, Witt Hamer, Philip C. de, Pallud, Johan, Bello, Lorenzo, Thomé, Claudius, Duffau, Hugues, and Mandonnet, Emmanuel

Abstract

Objective: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. Methods: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery. Results: A total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI. Conclusion: A minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of ≤ 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET. Importance of the study: We believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed "minimal core of imaging" in clinical routine will facilitate future cooperative studies.

Published
2018

44. fMRI study of graduated emotional charge for detection of covert activity using passive listening to narratives

Author

Sontheimer , Anna, Vassal , François, Jean , Betty, Feschet , Fabien, Lubrano , Vincent, Lemaire , Jean-Jacques, Image Guided Clinical Neurosciences and Connectomics (IGCNC), Université d'Auvergne (Clermont Ferrand 1) ( UdA ), Institut Pascal - Clermont Auvergne ( IP ), Sigma CLERMONT ( Sigma CLERMONT ) -Université Clermont Auvergne ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Service de Neurochirurgie [Saint Etienne], Centre Hospitalier Universitaire de Saint-Etienne ( CHU de Saint-Etienne ), Centre Hospitalier Universitaire de Clermont-Ferrand, Hôpital Purpan [Toulouse], Université d'Auvergne - Clermont-Ferrand I (UdA), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), CHU Toulouse [Toulouse], Lemaire, Jean-Jacques, SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Neurochirurgie [CHU Saint-Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Toulouse Neuro Imaging Center ( ToNIC ), Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale ( INSERM )

Subjects
voice familiarity, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, semantic memory, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, speech, [SCCO.NEUR] Cognitive science/Neuroscience, autobiographical memory, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [ SCCO.NEUR ] Cognitive science/Neuroscience, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, disorders of consciousness
Abstract

International audience; —Detection of awareness in patients with consciousness disorders is a challenge that can be facilitated by functional neuroimaging. We elaborated a functional magnetic resonance imaging (fMRI) protocol to detect cov-ert activity in altered states of consciousness. We hypothesized that passive listening to narratives with graduated emotional charge triggers graduated cerebral activations. The fMRI protocol was designed in healthy subjects for further clinical applications. The emotional charge was graduated using voice familiarity and long-term declarative memory content: low emotional charge, unknown person telling general semantic memory; mean emotional charge, relative telling the same narratives; high emotional charge, same relative telling autobiographical memory. Autobiographical memory was subdivided into semantic autobiographical memory and episodic autobiographical memory. The protocol proved efficient at triggering graduated cere-bral activations: low emotional charge, superior temporal gyri and sulci; mean emotional charge, same as low emotional charge plus bilateral premotor cortices and left inferior frontal gyrus; high emotional charge, cingulate, temporal, frontal, prefrontal and angular areas, thalamus and cerebellum. Semantic autobiographical memory revealed larger activations than episodic autobiographical memory. Independent ROI analysis confirmed the prepon-derant contribution of narratives with autobiographical memory content in triggering cerebral activation, not only in autobiographical memory-sensitive areas, but also in voice-sensitive, language-sensitive and semantic memory-sensitive areas. Ó 2017 The Authors. Published by Elsevier Ltd on behalf of IBRO. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

Published
2017

46. Evidenced-based medicine in glioma : molecular biology is only part of the story

Author

Duffau, Hugues, Mandonnet, Emmanuel, Pallud, Johan, Krieg, Sandro, Gil Robles, Santiago, Hamer, Philip de Witt, Schucht, Philippe, Zetterling, Maria, Santarius, Thomas, Colle, Henry, Ryan, Mathew, Smits, Anja, von Campe, Gord, Bello, Lorenzo, Forster, Marie-Therese, Sarubbo, Silvio, Spena, Giannantonio, Baron, Marie-Helene, Yordanova, Yordanka, Darlix, Amelie, Viegas, Catarina, Almairac, Fabien, Martino, Juan, Goodden, John, Chumas, Paul, Freyschlag, Christian, Robe, Pierre, Wager, Michel, Polivka, Marc, Giakoumettis, Dimitris, Robert, Erik, Guillevin, Remy, Grivas, Athanasios, Fontaine, Denys, van Geemen, Kim, Lubrano, Vincent, Rutten, Geert-Jan, Barone, Fabio, Rofes, Adria, Rech, Fabien, Rigau, Valerie, Wagemakers, Michiel, Papagno, Costanza, Aerts, Annelies, Visch-Brink, Evy, Tate, Matthew, Garg, Neha, Klein, Martin, Satoer, Djaina, de Witte, Elke, Van Brussel, Lore, Reyes, Andres, van Ierschot, Fleur, Veenstra, Wencke, Snijders, Tom, Taillandier, Luc, Blonski, Marie, Duffau, Hugues, Mandonnet, Emmanuel, Pallud, Johan, Krieg, Sandro, Gil Robles, Santiago, Hamer, Philip de Witt, Schucht, Philippe, Zetterling, Maria, Santarius, Thomas, Colle, Henry, Ryan, Mathew, Smits, Anja, von Campe, Gord, Bello, Lorenzo, Forster, Marie-Therese, Sarubbo, Silvio, Spena, Giannantonio, Baron, Marie-Helene, Yordanova, Yordanka, Darlix, Amelie, Viegas, Catarina, Almairac, Fabien, Martino, Juan, Goodden, John, Chumas, Paul, Freyschlag, Christian, Robe, Pierre, Wager, Michel, Polivka, Marc, Giakoumettis, Dimitris, Robert, Erik, Guillevin, Remy, Grivas, Athanasios, Fontaine, Denys, van Geemen, Kim, Lubrano, Vincent, Rutten, Geert-Jan, Barone, Fabio, Rofes, Adria, Rech, Fabien, Rigau, Valerie, Wagemakers, Michiel, Papagno, Costanza, Aerts, Annelies, Visch-Brink, Evy, Tate, Matthew, Garg, Neha, Klein, Martin, Satoer, Djaina, de Witte, Elke, Van Brussel, Lore, Reyes, Andres, van Ierschot, Fleur, Veenstra, Wencke, Snijders, Tom, Taillandier, Luc, and Blonski, Marie

Published
2017
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48. 3D Virtual Operating Room : un outil pour accompagner le changement des pratiques dans la gestion des risques en bloc opératoire

Author

Verscheure, Ingrid, Pons Lelardeux, Catherine, Rodsphon, Thomas, Minville, Vincent, Lubrano, Vincent, Université Toulouse - Jean Jaurès (UT2J), Real Expression Artificial Life (IRIT-REVA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Institut national universitaire Champollion [Albi] (INUC), CHU Toulouse [Toulouse], AECSE (Association des Enseignants et des Chercheurs en Sciences de l’Éducation), SSRE (Société Suisse pour la Recherche en Éducation), ABC-Educ (Association belge francophone des chercheurs en Education), and PONS LELARDEUX, Catherine

Subjects
[INFO.EIAH] Computer Science [cs]/Technology for Human Learning, [INFO.EIAH]Computer Science [cs]/Technology for Human Learning, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

49. Anatomical correlates for category‐specific naming of objects and actions: A brain stimulation mapping study

Author

Lubrano, Vincent, Filleron, Thomas, Démonet, Jean-François, Roux, Franck-Emmanuel, Serious Game Research Network (SGRN), Institut national universitaire Champollion [Albi] (INUC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Département d'oncologie médicale, Institut Claudius Regaud, Centre Leenaards de la Mémoire, Université de Lausanne (UNIL)-CHUV, Imagerie cérébrale et handicaps neurologiques (ICHN), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche cerveau et cognition (CERCO), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, Male, Brain Mapping, Language Disorders, Language Tests, Adolescent, Brain Neoplasms, [SCCO.NEUR]Cognitive science/Neuroscience, Reproducibility of Results, Middle Aged, Electric Stimulation, Semantics, Young Adult, Humans, Names, Female, Research Articles, Photic Stimulation, Aged
Abstract

The production of object and action words can be dissociated in aphasics, yet their anatomical correlates have been difficult to distinguish in functional imaging studies. To investigate the extent to which the cortical neural networks underlying object‐ and action‐naming processing overlap, we performed electrostimulation mapping (ESM), which is a neurosurgical mapping technique routinely used to examine language function during brain‐tumor resections. Forty‐one right‐handed patients who had surgery for a brain tumor were asked to perform overt naming of object and action pictures under stimulation. Overall, 73 out of the 633 stimulated cortical sites (11.5%) were associated with stimulation‐induced language interferences. These interference sites were very much localized (

Published
2012

50. MRI with DWI helps in depicting rheumatoid meningitis

Author

Roques, Margaux, primary, Tanchoux, Frédéric, additional, Calvière, Lionel, additional, Cuinat, Line, additional, Lubrano, Vincent, additional, Uro-Coste, Emmanuelle, additional, Cognard, Christophe, additional, Larrue, Vincent, additional, and Bonneville, Fabrice, additional

Published
2014
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