1. Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review.
- Author
-
Zwart, N.R.K., Franken, M.D., Tissing, W.J.E., Lubberman, F.J.E., McKay, J.A., Kampman, E., Kok, D.E., Zwart, N.R.K., Franken, M.D., Tissing, W.J.E., Lubberman, F.J.E., McKay, J.A., Kampman, E., and Kok, D.E.
- Abstract
01 augustus 2023, Contains fulltext : 295994.pdf (Publisher’s version ) (Open Access), Folate metabolism is a target for various chemotherapeutic drugs. Folate and its synthetic variant folic acid are B-vitamins. To what extent these vitamins impact treatment tolerance in patients with cancer remains unclear. A systematic literature review was conducted on intake and status of folate and folic acid in relation to chemotherapy-induced toxicities in children and adults with cancer. A total of 6231 publications were identified, of which 40 publications met the inclusion criteria. In 12 out of 22 studies focusing on antifolates, a deficient folate status and lower folate and folic acid intake were associated with a higher risk of toxicities. In 8 out of 14 studies focusing on fluoropyrimidine treatments, a higher folate status and intake were associated with a higher risk of toxicities. These findings might explain interindividual differences in treatment tolerance and highlight the importance of evaluating nutritional status in oncology care.
- Published
- 2023