1. Diurnal cortisol and survival in epithelial ovarian cancer
- Author
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Schrepf, Andrew, Thaker, Premal H, Goodheart, Michael J, Bender, David, Slavich, George M, Dahmoush, Laila, Penedo, Frank, DeGeest, Koen, Mendez, Luis, Lubaroff, David M, Cole, Steven W, Sood, Anil K, and Lutgendorf, Susan K
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Ovarian Cancer ,Neurosciences ,Rare Diseases ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Aged ,Ascitic Fluid ,Carcinoma ,Ovarian Epithelial ,Circadian Rhythm ,Female ,Humans ,Hydrocortisone ,Hypothalamo-Hypophyseal System ,Inflammation ,Interleukin-6 ,Middle Aged ,Neoplasms ,Glandular and Epithelial ,Ovarian Neoplasms ,Pituitary-Adrenal System ,Prognosis ,Proportional Hazards Models ,Saliva ,Ovarian neoplasms ,Chronobiology disorders ,Biological markers ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biomedical and clinical sciences ,Psychology - Abstract
IntroductionHypothalamic-pituitary-adrenal (HPA) deregulation is commonly observed in cancer patients, but its clinical significance is not well understood. We prospectively examined the association between HPA activity, tumor-associated inflammation, and survival in ovarian cancer patients prior to treatment.Materials and methodsParticipants were 113 women with ovarian cancer who provided salivary cortisol for three days prior to treatment for calculation of cortisol slope, variability, and night cortisol. Cox proportional hazard regression analyses were used to examine associations between cortisol and survival in models adjusting for disease stage, tumor grade, cytoreduction and age. On a subsample of 41 patients with advanced disease ascites fluid was assayed for levels of interleukin-6 (IL-6) and correlated with cortisol variables.ResultsEach cortisol measure was associated with decreased survival time, adjusting for covariates (all p36, all p
- Published
- 2015