1. Serological biomarkers in autoimmune GFAP astrocytopathy
- Author
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Cong-Cong Fu, Lu Huang, Lu-Fen Xu, Li-Hong Jiang, Hui-Lu Li, Sha Liao, Jiajia Yue, Chun Lian, Xin-Guang Yang, and You-Ming Long
- Subjects
GFAP-A ,autoantibody ,autoimmune encephalitis ,MIP 3 alpha ,CSF abnormalities ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a newly defined meningoencephalomyelitis. The pathogenesis of GFAP-A is not well understood. The present study measured the expression levels of 200 serological cytokines in GFAP-A patients, NMOSD patients and healthy controls (HCs). The correlations between serum cytokine levels and clinical information in GFAP-A patients were analyzed. A total of 147 serological proteins were differentially expressed in GFAP-A patients compared to HCs, and 33 of these proteins were not observed in NMOSD patients. Serum levels of EG-VEGF negatively correlated with GFAP antibody titers, MIP-3 alpha positively correlated with clinical severity in GFAP-A patients, and LIGHT positively correlated with WBC counts and protein levels in the CSF of GFAP-A patients. These results suggest that GFAP and AQP4 astrocytopathy share some common pathology related to TNF signaling. Serum MIP 3 alpha may be a biomarker to assess clinical severity and a potential target for therapy of autoimmune GFAP astrocytopathy.
- Published
- 2022
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