21,015 results on '"Lu W."'
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2. Intrinsic Capacity Impairments (ICOPE Step 1 and Step 2), Cardiometabolic Risk and Immune Resilience: An Exploratory Analysis from the Gan-Dau Healthy Longevity Plan
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Chen, Z.-J., Lu, W.-H., Meng, L.-C., Chao, W.-F., Tung, H.-H., Hsiao, Fei-Yuan, and Chen, Liang-Kung
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- 2024
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3. X-Type Antiferromagnets
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Zhang, Shui-Sen, Wang, Zi-An, Li, Bo, Zhang, Shu-Hui, Xiao, Rui-Chun, Liu, Lan-Xin, Luo, X., Lu, W. J., Tian, Mingliang, Sun, Y. P., Tsymbal, Evgeny Y., Du, Haifeng, and Shao, Ding-Fu
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Magnetically ordered materials reveal various types of magnetic moment alignment that affects their functional properties. This makes the exploration of unconventional magnetic orderings promising for the discovery of new physical phenomena and spintronic applications. Here, we introduce cross-chain antiferromagnets, dubbed X-type antiferromagnets, as an uncharted class of magnetically ordered crystals, where the stacking of two magnetic sublattices form an orthogonal pattern of intersecting atomic chains. These largely unexplored X-type antiferromagnets reveal unique spin-dependent transport properties that are not present in conventional magnets. Using $\beta$-Fe2PO5 as a representative example of such X-type antiferromagnets, we predict the emergence of sublattice-selective spin-polarized transport, where one magnetic sublattice is conducting, while the other is not. As a result, spin torque can be exerted solely on a single sublattice, leading to unconventional ultrafast dynamics of the N\`eel vector capable of deterministic switching of the antiferromagnetic domains. Our work uncovers a previously overlooked type of magnetic moment alignment in antiferromagnets and reveals sublattice-selective physical properties promising for high-performance spintronic applications.
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- 2023
4. Self-Reported Fatigue and Its Cross-Sectional Associations with Physical Function throughout Adulthood: The INSPIRE-T Cohort
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Matsumoto, Daisuke, Raffin, J., Lu, W.-H., Guyonnet, S., Pillard, F., Rolland, Y., Vellas, B., and de Souto Barreto, P.
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- 2024
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5. Prediction of Giant Tunneling Magnetoresistance in RuO$_{2}$/TiO$_{2}$/RuO$_{2}$ (110) Antiferromagnetic Tunnel Junctions
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Jiang, Yuan-Yuan, Wang, Zi-An, Samanta, Kartik, Zhang, Shu-Hui, Xiao, Rui-Chun, Lu, W. J., Sun, Y. P., Tsymbal, Evgeny Y., and Shao, Ding-Fu
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Using first-principles quantum-transport calculations, we investigate spin-dependent electronic and transport properties of antiferromagnetic tunnel junctions (AFMTJs) that consist of (110)-oriented antiferromagnetic (AFM) metal RuO$_{2}$ electrodes and an insulating TiO$_{2}$ tunneling barrier. We predict the emergence of a giant tunneling magnetoresistance (TMR) effect in a wide energy window, a series of barrier layer thicknesses, and different interface terminations, indicating the robustness of this effect. We show that the predicted TMR cannot be explained in terms of the global transport spin-polarization of RuO$_{2}$ (110) but is well understood based on matching the momentum-dependent spin-polarized conduction channels of the two RuO$_{2}$ (110) electrodes. We predict oscillations of TMR with increasing barrier thickness, indicating a non-negligible contribution from the perfectly epitaxial interfaces. Our work helps the understanding of the physics of TMR in AFMTJs and aids in realizing efficient AFM spintronic devices., Comment: The colorbar of originl Fig. 2a was not set properly, which is corrected in this version. To be published in PRB
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- 2023
6. Electrochemically-controlled metasurfaces with high-contrast switching at visible frequencies
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Kaissner, R., Li, J. X., Lu, W. Z., Li, X., Neubrech, F., Wang, J. F., and Liu, N.
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Physics - Optics ,Physics - Applied Physics - Abstract
Recently in nanophotonics, a rigorous evolution from passive to active metasurfaces has been witnessed. This advancement not only brings forward interesting physical phenomena but also elicits opportunities for practical applications. However, active metasurfaces operating at visible frequencies often exhibit low performance due to design and fabrication restrictions at the nanoscale. In this work, we demonstrate electrochemically controlled metasurfaces with high intensity contrast, fast switching rate, and excellent reversibility at visible frequencies. We use a conducting polymer, polyaniline (PANI), that can be locally conjugated on preselected gold nanorods to actively control the phase profiles of the metasurfaces. The optical responses of the metasurfaces can be in situ monitored and optimized by controlling the PANI growth of subwavelength dimension during the electrochemical process. We showcase electrochemically controlled anomalous transmission and holography with good switching performance. Such electrochemically powered optical metasurfaces lay a solid basis to develop metasurface devices for real-world optical applications.
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- 2023
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7. Do gravitational wave observations in the lower mass gap favor a hierarchical triple origin?
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Gayathri, V., Bartos, I., Rosswog, S., Miller, M. C., Veske, D., Lu, W., and Marka, S.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Observations of compact objects in Galactic binaries have provided tentative evidence of a dearth of masses in the so-called lower mass gap $\sim2.2-5$ M$_\odot$. Nevertheless, two such objects have been discovered in gravitational-wave data from LIGO and Virgo. Remarkably, the estimated masses of both secondaries in the coalescences GW190814 ($m_2=2.59^{+0.08}_{-0.09}$M$_\odot$) and GW200210_092254 ($m_2=2.83^{+0.47}_{-0.42}$M$_\odot$) fall near the total mass of $\sim 2.6$ M$_\odot$ of observed Galactic binary neutron star systems. The more massive components of the two binaries also have similar masses. Here we show that a neutron star merger origin of the lighter components in GW190814 and GW200210_092254 is favored over $M^{-2.3}$ (Bayes factor $\mathcal{B}\sim 5$) and uniform ($\mathcal{B}\sim 14$) mass distributions in the lower mass gap. We also examine the statistical significance of the similarity between the heavier component masses of GW190814 and GW200210_092254, and find that a model in which the mass of GW200210_092254 is drawn from the mass posterior of GW190814 is preferred ($\mathcal{B}\sim 18$) to a model in which its mass is drawn from the overall mass distribution of black holes detected in gravitational wave events. This hints at a common origin of the primary masses, as well as the secondary masses, in GW190814 and GW200210_092254., Comment: 6 pages, 2 figures
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- 2023
8. Frailty Predicts in-Hospital Death in Traumatic Brain Injury Patients: A Retrospective Cohort Study
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Liu H, Wu W, Xu M, Ling X, Lu W, Cheng F, and Wang J
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frailty ,traumatic brain injury ,in-hospital mortality ,prognosis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Hua Liu,1,* Wenxi Wu,1,* Min Xu,2 Xiaoyang Ling,2 Wei Lu,2 Feng Cheng,1 Jian Wang2 1Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, People’s Republic of China; 2Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, 215300, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Cheng, Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, People’s Republic of China, Email chengf1215@163.com Jian Wang, Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Kunshan, 215300, People’s Republic of China, Email wj458381670@126.comBackground and Aim: Traumatic brain injury (TBI) is a severe public health problem in elderly patients, and frailty is associated with higher mortality rates in older patients. This study aims to assess the prognostic value of frailty in patients with TBI.Methods: Clinical data from 348 TBI patients treated at Affiliated Kunshan Hospital of Jiangsu University and Kunshan Hospital of Traditional Chinese Medicine between December 2018 and December 2020 were retrospectively collected. Univariate and multivariate logistic regression analyses were used to determine risk factors affecting in-hospital mortality, and receiver operating characteristic (ROC) curves were plotted to assess the discriminatory power of the frailty index. Frailty was assessed using the FRAIL scale, where FRAIL stands for Fatigue, Resistance, Ambulation, Illness, and Loss of weight, with each item scored as 0 or 1.Results: Using the FRIAL questionnaire, 122 patients had low frailty and 226 had high frailty. Multivariate logistic regression analysis showed that high frailty was a risk factor for in-hospital mortality in TBI patients (P< 0.001, OR=2.012 [1.788– 2.412]). The proportion of infections occurring in the two groups was statistically different (P=0.015), with severely infected TBI patients being more likely to develop complications. The ROC curve showed an area under the curve for the FRAIL score of 0.845 [0.752– 0.938].Conclusion: Frailty is an important risk factor for in-hospital mortality in elderly TBI patients, and more attention should be paid to patients with high levels of frailty. Clinicians should consider the degree of frailty when assessing TBI and making treatment decisions.Keywords: frailty, traumatic brain injury, in-hospital mortality, prognosis
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- 2024
9. Hepatoma-Targeting and ROS-Responsive Polymeric Micelle-Based Chemotherapy Combined with Photodynamic Therapy for Hepatoma Treatment
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Xu X, Lu W, Zhang H, Wang X, Huang C, Huang Q, and Xu W
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ros-responsive polymeric micelles ,photodynamic therapy ,hepatoma-targeting ,celastrol ,combination anti-hepatoma therapy ,Medicine (General) ,R5-920 - Abstract
Xueya Xu,* Weili Lu,* Hua Zhang, Xiaoying Wang, Caixia Huang, Qiuping Huang, Wen Xu, Wei Xu Pharmacy College, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoying Wang; Wei Xu, Pharmacy College, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Fuzhou, 350122, People’s Republic of China, Email 2003032@fjtcm.edu.cn; 2000017@fjtcm.edu.cnBackground: The combination of nanoplatform-based chemotherapy and photodynamic therapy (PDT) is a promising way to treat cancer. Celastrol (Cela) exhibits highly effective anti-hepatoma activity with low water solubility, poor bioavailability, non-tumor targeting, and toxic side effects. The combination of Cela-based chemotherapy and PDT via hepatoma-targeting and reactive oxygen species (ROS)-responsive polymeric micelles (PMs) could solve the application problem of Cela and further enhance antitumor efficacy.Methods: In this study, Cela and photosensitizer chlorin e6 (Ce6) co-loaded glycyrrhetinic acid-modified carboxymethyl chitosan-thioketal-rhein (GCTR) PMs (Cela/Ce6/GCTR PMs) were prepared and characterized. The safety, ROS-sensitive drug release, and intracellular ROS production were evaluated. Furthermore, the in vitro anti-hepatoma effect and cellular uptaken in HepG2 and BEL-7402 cells, and in vivo pharmacokinetic, tissue distribution, and antitumor efficacy of Cela/Ce6/GCTR PMs in H22 tumor-bearing mice were then investigated.Results: Cela/Ce6/GCTR PMs were successfully prepared with nanometer-scale particle size, favorable drug loading capacity, and encapsulation efficiency. Cela/Ce6/GCTR PMs exhibited a strong safety profile and better hemocompatibility, exhibiting less damage to normal tissues. Compared with Cela-loaded GCTR PMs, the ROS-responsiveness of Cela/Ce6/GCTR PMs was increased, and the release of Cela was accelerated after combination with PDT. Cela/Ce6/GCTR PMs can efficiently target liver tumor cells by uptake and have a high cell-killing effect in response to ROS. The combination of GCTR PM-based chemotherapy and PDT resulted in increased bioavailability of Cela and Ce6, improved liver tumor targeting, and better anti-hepatoma effects in vivo.Conclusion: Hepatoma-targeting and ROS-responsive GCTR PMs co-loaded with Cela and Ce6 combined with PDT exhibited improved primary hepatic carcinoma therapeutic effects with lower toxicity to normal tissues, overcoming the limitations of monotherapy and providing new strategies for tumor treatment. Keywords: ROS-responsive polymeric micelles, photodynamic therapy, hepatoma-targeting, celastrol, combination anti-hepatoma therapy
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- 2024
10. Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanism of Qushi Huatan Decoction Against Coronary Heart Disease
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Yin C, Lan T, Wu Y, Cai J, Li H, Kuang X, Jiao L, Ou X, Yang H, Liu B, and Lu W
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network pharmacology ,molecular docking ,qushi huatan decoction ,coronary heart disease ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Chunxia Yin,1,* Taohua Lan,2,3,* Yunshan Wu,4,5 Jing Cai,1 Haoxiang Li,1 Xiaolan Kuang,1 Lin Jiao,1 Xiaomin Ou,1 Hua Yang,2 Bo Liu,3– 5 Weihui Lu2,6,7 1The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, People’s Republic of China; 3State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 4Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, People’s Republic of China; 5Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 6State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 7Chinese Medicine Guangdong Laboratory, Guangdong Hengqin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weihui Lu, Bo Liu, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Email weihui.lu@gzucm.edu.cn; doctliu@gzucm.edu.cnPurpose: This study was designed to evaluate the effect and mechanism of the Qushi Huatan (QSHT) decoction against coronary heart disease (CHD) through network pharmacology and experimental verification.Methods: In the present study, the active ingredients of the QSHT decoction were identified by ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS), then the potential ingredients and coronary heart disease targets were predicted using the SwissTarget Prediction database and the database of Genecards and OMIM database, respectively. A herb-compound-target network was constructed using Cytoscape. GO and KEGG enrichment analysis were performed using the ClusterProfiler data package of R software. Molecular docking was used to predict the core targets of QSHT against CHD. In addition, we used a myocardial infarction (MI) and high-fat diet ApoE−/− mice model to investigate the cardioprotective effects of QSHT. Western blotting and immunochemistry were used to verify the core targets and the signaling pathway.Results: A total of 68 active ingredients were found in the QSHT decoction. Network pharmacology indicated 28 targets and 147 signal pathways, including AKT1, HIF-1α, GSK-3β, TLR4 and NF-κB, those key targets were also verified by molecular docking. The results of GO and KEGG enrichment analysis showed that the targets of QSHT against CHD were largely associated with inflammatory and oxidative stress, and AKT/HIF-1α and TLR4/NF-κB pathways might be key functional pathways. In vivo, QSHT significantly improved cardiac function and attenuated fibrosis and inflammation. Furthermore, QSHT could significantly inhibit the expression of HIF-1α, TLR4, phosphorylation of AKT1, GSK-3β and NF-κB after MI in ApoE−/− mice.Conclusion: Based on network pharmacology, molecular docking and experimental verification, this study demonstrated that QSHT could improve cardiac function and attenuate cardiac fibrosis by regulating TLR4/NF-κB and AKT/HIF-1α signaling pathway in post- MI and high-fat diet ApoE−/− mice.Keywords: network pharmacology, molecular docking, Qushi Huatan decoction, coronary heart disease
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- 2024
11. Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation
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Lu W, Yang Z, Wang M, Zhang Y, Qi Z, and Yang X
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infantile hemangioma ,entinostat ,sirolimus ,hub gene ,transcriptome ,bioinformatics ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Wei Lu,* Zhenyu Yang,* Mengjie Wang, Ye Zhang, Zuoliang Qi, Xiaonan Yang Department of Hemangioma and Vascular Malformation, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaonan Yang, Department of Hemangioma and Vascular Malformation, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, People’s Republic of China, Email yxnan@aliyun.comIntroduction: Infantile Hemangioma (IH) is a prevalent benign vascular tumor affecting approximately 5– 10% of infants. Its underlying pathogenesis remains enigmatic, and current therapeutic approaches show limited effectiveness. Our study aimed to discover potential IH-associated therapeutics through a transcriptomic, computational drug repurposing methodology.Methods: Utilizing the IH-specific dataset GSE127487 from the Gene Expression Omnibus, we identified differentially expressed genes (DEGs) and conducted weighted gene coexpression network analysis (WGCNA). Subsequently, a protein-protein interaction (PPI) network was constructed to obtain the top 100 hub genes. Drug candidates were sourced from the Connectivity Map (CMap) and Comparative Toxicogenomics Database (CTD).Results: Our analysis revealed 1203 DEGs and a significant module of 1780 mRNAs strongly correlated with IH. These genes were primarily enriched in the PI3K/AKT/MTOR, RAS/MAPK, and CGMP/PKG signaling pathway. After creating a PPI network of overlapping genes, we filtered out the top 100 hub genes. Ultimately, 44 non-toxic drugs were identified through the CMap and CTD databases. Twelve molecular-targeting agents (belinostat, chir 99021, dasatinib, entinostat, panobinostat, sirolimus, sorafenib, sunitinib, thalidomide, U 0126, vorinostat, and wortmannin) may be potential candidates for IH therapy. Moreover, in vitro experiments demonstrated that entinostat, sorafenib, dasatinib, and sirolimus restricted the proliferation and migration and initiated apoptosis in HemEC cells, thereby underscoring their potential therapeutic value.Conclusion: Our investigation revealed that the pathogenic mechanism underlying IH might be closely associated with the PI3K/AKT/MTOR, RAS/MAPK, and CGMP/PKG signaling pathways. Furthermore, we identified twelve molecular-targeting agents among the predicted drugs that show promise as therapeutic candidates for IH.Plain Language Summary: Transcriptomic analysis used to discover potential therapeutics for Infantile Hemangioma (IH).Key IH-related pathways: PI3K/AKT/MTOR, RAS/MAPK, and CGMP/PKG signaling identified.Identified 44 non-toxic drugs as potential IH therapies via CMap and CTD.Twelve molecular agents show potential as IH therapy candidates.In vitro studies confirmed entinostat, sorafenib, dasatinib, and sirolimus inhibit HemEC cell proliferation and induce apoptosis. Keywords: infantile hemangioma, entinostat, sirolimus, hub gene, transcriptome, bioinformatics
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- 2024
12. Mechanism of YJKL Decoction in Treating of PCOS Infertility by Integrative Approach of Network Pharmacology and Experimental Verification
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Zhang R, Xu W, Wei H, Li B, Wang Y, He X, Cao J, Xu M, Lu W, and Xu Y
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traditional chinese medicine ,yjkl ,polycystic ovary syndrome ,pcos ,molecular docking ,experimental validation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Rongrong Zhang,1,* Wenjun Xu,1,* Hongquan Wei,1,* Boshi Li,1 Yaoxing Wang,1 Xueqing He,1 Jun Cao,1 Xinyu He,1 Mingxiang Xu,1,2 Wenjie Lu,1 Youzhi Xu1 1College of Basic Medicine, Anhui Medical University, Hefei, 230032, People’s Republic of China; 2Center for Scientific Research, Anhui Medical University, Hefei, 230032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youzhi Xu; Wenjie Lu, Email xuyouzhi@ahmu.edu.cn; wenjie63136@163.comPurpose: Currently, there is still no clear treatment for polycystic ovary syndrome (PCOS). YJKL has better therapeutic effects and lower toxic side effects for PCOS type infertility. This study aims to clarify the potential mechanism of YJKL Decoction in the treatment of PCOS based on network pharmacology and experiments verification.Patients and Methods: Network pharmacology and experimental validation approach were used to investigate the bioactive ingredients, critical targets and potential mechanisms of YJKL Decoction against PCOS. Firstly, we use network pharmacology methods to collect core targets, and then validate their effects on diseases through experiments.Results: Five core targets were screened, Threonine kinase 1 (AKT1), Cellular tumor antigen p53 (TP53), Tumor necrosis factor (TNF), Albumin (ALB) and Vascular endothelial growthfactor A (VEGFA). KEGG analysis showed that YJKL treatment for PCOS mainly include AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway and HIF-1 signaling pathway. The molecular docking results showed that compounds have higher affinity with targets. Finally, experimental results had shown that YJKL Decoction had an better therapeutic effects in the treatment of PCOS.Conclusion: Based on a systematic network pharmacology approach and experimental verification, our results comprehensively illustrated the active ingredients, potential targets, and molecular mechanism of YJKL for application to PCOS and helps to illustrate mechanism of action on a comprehensive level.Keywords: traditional Chinese Medicine, YJKL, polycystic ovary syndrome, PCOS, molecular docking, experimental validation
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- 2024
13. Comparison of TyG and Newly TyG Related Indicators for Chronic Kidney Diseases Estimation in a Chinese Population
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Chen T, Liu Y, Wu S, Long S, Feng L, Lu W, Chen W, Hong G, Zhou L, Wang F, Luo Y, Zou H, and Liu W
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chronic kidney disease ,insulin resistance ,obesity ,tyg related indicators ,Specialties of internal medicine ,RC581-951 - Abstract
Tong Chen,1– 4 Yu Liu,2,3 Shiquan Wu,2 Siyu Long,2 Ling Feng,4,5 Wenqian Lu,6 Wenya Chen,2 Guoai Hong,2 Li Zhou,2 Fang Wang,2 Yuechan Luo,2 Hequn Zou,2,4,6 Weihua Liu7 1Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, People’s Republic of China; 2South China Hospital of Shenzhen University, Shenzhen, 518116, People’s Republic of China; 3Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, People’s Republic of China; 4Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 5Department of Nephrology, Shenzhen Hospital, Southern Medical University, Shenzhen, People’s Republic of China; 6School of Medicine, The Chinese University of Hong Kong, Shenzhen, People’s Republic of China; 7Department Nephrology of Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian, 350001, People’s Republic of ChinaCorrespondence: Weihua Liu, Department Nephrology of Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fujian, 350001, People’s Republic of China, Email lwh10280465@163.com Hequn Zou, School of Medicine, The Chinese University of Hong Kong, Shenzhen, People’s Republic of China, Email zouhequn@cuhk.edu.cnBackground: Obesity and insulin resistance (IR) are positively associated with chronic kidney disease (CKD). Previous studies have identified triglyceride-glucose index (TyG) as a valuable surrogate of insulin resistance. Recently, new indicators combining TyG and simple anthropometric indices have emerged, The objective of this study was to assess the diagnostic accuracy of TyG and newly TyG related indicators in detecting CKD and explore which indices were superior in associating with CKD in Chinese population.Methods: Correlation test, logistic regression analysis, and receiver operating characteristic (ROC) analyses were used to evaluate the optimal cut-off and value of TyG, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist to height ratio (TyG-WHtR) for predicting CKD.Results: TyG-WHtR, TyG-WC, and TyG-BMI correlated with several risk factors for CKD. After adjusting for confounders, TyG-WHtR and TyG-WC remained significantly associated with CKD, while TyG-BMI did not. The highest quartiles of TyG-WHtR and TyG-WC had 1.95- and 1.91-fold increased risk of CKD than the lowest quartiles (P< 0.05). TyG-WHtR had the largest AUC (0.687) for CKD detection, followed by TyG-WC (0.669), TyG (0.652), and TyG-BMI (0.648). A united model that involved TyG-WHtR and other risk variables had higher predictive performance (AUC=0.791) than a single TyG related indicator. However, TyG had the highest OR (2.713, 95% CI, 1.446– 5.090) for reduced eGFR in the fully adjusted model. A united model that involved TyG and WHtR separately had stronger predictive ability (AUC: 0.794) than the model that involved TyG-WHtR individually (AUC:0.791).Conclusion: This study found that TyG-WHtR had a better diagnostic value in the diagnosis of CKD, compared to other TyG related indicators, but none of the TyG related indicators showed a stronger association with CKD than TyG. Further research and more refined algorithms are needed to verify these new indicators.Keywords: chronic kidney disease, insulin resistance, obesity, TyG related indicators
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- 2024
14. Fe3O4 Nanoparticles That Modulate the Polarisation of Tumor-Associated Macrophages Synergize with Photothermal Therapy and Immunotherapy (PD-1/PD-L1 Inhibitors) to Enhance Anti-Tumor Therapy
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Sun H, Wang X, Guo Z, Hu Z, Yin Y, Duan S, Jia W, Lu W, and Hu J
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photothermal therapy ,immunotherapy ,tumor-associated macrophages ,head and neck squamous cell carcinoma ,Medicine (General) ,R5-920 - Abstract
Haishui Sun,1,* Xiao Wang,2,3,* Zhaoyang Guo,4,* Zhenrong Hu,5 Yuanchen Yin,4 Shuhan Duan,6 Wenwen Jia,2 Wei Lu,2,3 Jingzhou Hu1,7 1Department of Oral and Maxillofacial - Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, People’s Republic of China; 2Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of D&A for Metal Functional Materials, School of Materials Science and Engineering, Tongji University, Shanghai, People’s Republic of China; 4School of Stomatology, Weifang Medical University, Weifang, Shandong Province, People’s Republic of China; 5Department of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 6Shanghai Key Laboratory of Stomatology, Department of Oral Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Research Institute of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 7Department of Oral and Maxillofacial Surgery, Zhang Zhiyuan Academician Workstation, Hainan Western Central Hospital, Shanghai Ninth People’s Hospital, Danzhou, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingzhou Hu; Wei Lu, Email huyayi@shsmu.edu.cn; weilu@tongji.edu.cnIntroduction: Traditional surgical resection, radiotherapy, and chemotherapy have been the treatment options for patients with head and neck squamous cell carcinoma (HNSCC) over the past few decades. Nevertheless, the five-year survival rate for patients has remained essentially unchanged, and research into treatments has been relatively stagnant. The combined application of photothermal therapy (PTT) and immunotherapy for treating HNSCC has considerable potential.Methods: Live-dead cell staining and CCK-8 assays proved that Fe3O4 nanoparticles are biocompatible in vitro. In vitro, cellular experiments utilized flow cytometry and immunofluorescence staining to verify the effect of Fe3O4 nanoparticles on the polarisation of tumor-associated macrophages. In vivo, animal experiments were conducted to assess the inhibitory effect of Fe3O4 nanoparticles on tumor proliferation under the photothermal effect in conjunction with BMS-1. Tumour tissue sections were stained to observe the effects of apoptosis and the inhibition of tumor cell proliferation. The histological damage to animal organs was analyzed by hematoxylin and eosin (H&E) staining.Results: The stable photothermal properties of Fe3O4 nanoparticles were validated by in vitro cellular and in vivo animal experiments. Fe3O4 photothermal action not only directly triggered immunogenic cell death (ICD) and enhanced the immunogenicity of the tumor microenvironment but also regulated the expression of tumor-associated macrophages (TAMs), up-regulating CD86 and down-regulating CD206 to inhibit tumor growth. The PD-1/PD-L1 inhibitor promoted tumor suppression, and reduced tumor recurrence and metastasis. In vivo studies demonstrated that the photothermal action exhibited a synergistic effect when combined with immunotherapy, resulting in significant suppression of primary tumors and an extension of survival.Conclusion: In this study, we applied Fe3O4 photothermolysis in a biomedical context, combining photothermolysis with immunotherapy, exploring a novel pathway for treating HNSCC and providing a new strategy for effectively treating HNSCC.Keywords: photothermal therapy, immunotherapy, tumor-associated macrophages, head and neck squamous cell carcinoma
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- 2024
15. Connecting repeating and non-repeating fast radio bursts via their energy distributions
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Kirsten, F., Ould-Boukattine, O., Herrmann, W., Gawronski, M., Hessels, J., Lu, W., Snelders, M., Chawla, P., Yang, J., Blaauw, R., Nimmo, K., Puchalska, W., Wolak, P., and van Ruiten, R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Fast radio bursts (FRBs) are extremely energetic, millisecond-duration radio flashes that reach Earth from extragalactic distances. Broadly speaking, FRBs can be classified as repeating or (apparently) non-repeating. It is still unclear, however, whether the two types share a common physical origin, differing only in their activity rate. Here we report on an unprecedented observing campaign that targeted one hyperactive repeating source, FRB 20201124A, for more than $2000~\mathrm{hr}$ using four $25-32\mathrm{-m}$ class radio telescopes. In total, we detect $46$ high-energy bursts, many more than one would expect given previous observations of lower-energy bursts using larger radio telescopes. We find a high-energy burst distribution that resembles that of the non-repeating FRB population, suggesting that apparently non-repeating FRB sources may simply be the rarest bursts from repeating sources. We also discuss how FRB 20201124A contributes strongly to the all-sky FRB rate and how similar sources would be observable even at very high redshift., Comment: 25 pages, 9 figures. Submitted, comments welcome
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- 2023
16. Minimal Linear Codes Constructed from partial spreads
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Lu, W., Wu, X., Cao, X. W., Luo, G. J., and Qin, X. P.
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Computer Science - Information Theory - Abstract
Partial spread is important in finite geometry and can be used to construct linear codes. From the results in (Designs, Codes and Cryptography 90:1-15, 2022) by Xia Li, Qin Yue and Deng Tang, we know that if the number of the elements in a partial spread is ``big enough", then the corresponding linear code is minimal. They used the sufficient condition in (IEEE Trans. Inf. Theory 44(5): 2010-2017, 1998) to prove the minimality of such linear codes. In this paper, we use the geometric approach to study the minimality of linear codes constructed from partial spreads in all cases.
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- 2023
17. Minimal Linear Codes Constructed from hierarchical posets with two levels
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Wu, X., Lu, W., Qin, X. P., and Cao, X. W.
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Computer Science - Information Theory - Abstract
J. Y. Hyun, et al. (Des. Codes Cryptogr., vol. 88, pp. 2475-2492, 2020) constructed some optimal and minimal binary linear codes generated by one or two order ideals in hierarchical posets of two levels. At the end of their paper, they left an open problem: it also should be interesting to investigate the cases of more than two orders in hierarchical posets with two levels or many levels. In this paper, we use the geometric method to determine the minimality of linear codes generated by any orders in hierarchical posets with two levels. We generalize their cases of one or two orders to any orders and determine the minimality of the linear codes completely., Comment: arXiv admin note: text overlap with arXiv:1911.11632, arXiv:1911.07648
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- 2023
18. Implementation-Oriented Renewal Planning of Suburb Townlet in South Jiangsu: A Case Study of Zhangpu Old Town in Kunshan
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Wang, H. T., Gao, S. Q., Lu, W. Z., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Papadikis, Konstantinos, editor, Zhang, Cheng, editor, Tang, Shu, editor, Liu, Engui, editor, and Di Sarno, Luigi, editor
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- 2024
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19. Applications of Photogrammetry-Based 3D Reconstruction Approach for Cut Slope Monitoring
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Wang, Y., Koo, K. Y., Lu, W., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Gu, Xiang-Lin, editor, Motavalli, Masoud, editor, Ilki, Alper, editor, and Yu, Qian-Qian, editor
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- 2024
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20. Lattice distortion enabling enhanced strength and plasticity in high entropy intermetallic alloy
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Wang, H., Yang, P. Y., Zhao, W. J., Ma, S. H., Hou, J. H., He, Q. F., Wu, C. L., Chen, H. A., Wang, Q., Cheng, Q., Guo, B. S., Qiao, J. C., Lu, W. J., Zhao, S. J., Xu, X. D., Liu, C. T., Liu, Y., Pao, C. W., and Yang, Y.
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- 2024
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21. Microstructure and coupling mechanisms in MnBi–FeSiB nanocomposites obtained by spark plasma sintering
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Alexandru-Dinu, A., Locovei, C., Bartha, C., Grigoroscuta, M. A., Burdusel, M., Kuncser, A., Palade, P., Schinteie, G., Iacob, N., Lu, W., Batalu, D., Badica, P., and Kuncser, V.
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- 2024
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22. A link between repeating and non-repeating fast radio bursts through their energy distributions
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Kirsten, F., Ould-Boukattine, O. S., Herrmann, W., Gawroński, M. P., Hessels, J. W. T., Lu, W., Snelders, M. P., Chawla, P., Yang, J., Blaauw, R., Nimmo, K., Puchalska, W., Wolak, P., and van Ruiten, R.
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- 2024
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23. Dose-Responsive Impacts of Social Frailty on Intrinsic Capacity and Healthy Aging among Community-Dwelling Middle-aged and Older Adults: Stronger Roles of Social Determinants over Biomarkers
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Huang, S.-T., Lu, W.-H., Lee, W.-J., Peng, L.-N., Chen, Liang-Kung, and Hsiao, Fei-Yuan
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- 2024
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24. Reactivation Risk of Latent Tuberculosis or Inactive Hepatitis B Virus Infection and Effectiveness of Ustekinumab in Chinese Plaque Psoriasis Patients: A 28-Week Retrospective, Observational Study
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Lu W, Wang J, Zhang Y, Chang R, and Zhao J
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ustekinumab ,plaque psoriasis ,real-world effectiveness ,ltbi,inactive hbv infection ,Dermatology ,RL1-803 - Abstract
Wensheng Lu,1 JianFeng Wang,2 YuanJing Zhang,1 Ruixue Chang,1 Jun Zhao3 1Department of Dermatology, The No. 1 Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, People’s Republic of China; 2Department of Dermatology, The No. 1 Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, People’s Republic of China; 3Department of Dermatology, The Lu’an Hospital Affiliated to Anhui Medical University, Lu’an, Anhui, People’s Republic of ChinaCorrespondence: Wensheng Lu; Jun Zhao, Email 492051693@qq.com; 13085092159@163.comIntroduction: This study observed the effectiveness of ustekinumab and reactivation risk of concurrent latent tuberculosis infection (LTBI) and inactive hepatitis B virus (HBV) infection in Chinese mainland psoriasis patients on ustekinumab treatment.Methods: This retrospective, multicenter, observational study was conducted in three centers in China. Adult patients with moderate to severe plaque psoriasis were treated with ustekinumab for 28 weeks. The effectiveness endpoint included 75% and 90% improvement in Psoriasis Area Severity Index (PASI75/90) response rate, percentage of PASI improvement, change of absolute PASI score and body surface area involvement (BSA) score, absolute PASI ≤ 1/3 and Physicians’ Global Assessment (PGA)=0/1, as well as Dermatology life quality index (DLQI)=0/1 response rate at week 4, 16 and 28. Screening of tuberculosis and hepatitis were performed at baseline and week 28.Results: A total of 82 patients were enrolled between March 2021 and May 2023 and the number of patients combined with LTBI and inactive HBV infection was 20 and 21 respectively. The PASI75 and PASI90 response rate at week 28 was 95.1% and 81.7% respectively. The mean PASI score decreased from 14.93 ± 12.07 at baseline to 0.78 ± 1.86 at week 28, and the mean BSA score decreased from 21% ± 18% at baseline to 1% ± 2% at week 28 (both P< 0.001 compared with baseline). DLQI 0/1 response rate at week 28 was 73.2%. No reactivation of LTBI and inactive HBV infection and also no new-onset tuberculosis and hepatitis B occurred in patients without LTBI and inactive HBV infection at baseline.Conclusion: Ustekinumab demonstrated great effectiveness in Chinese plaque psoriasis patients and good safety in psoriasis concurrent with LTBI and inactive HBV infection under the real-world setting.Keywords: ustekinumab, plaque psoriasis, real-world effectiveness, LTBI, inactive HBV infection
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- 2024
25. Molecular Characteristics of Virulence Genes in Carbapenem-Resistant and Carbapenem-Sensitive Klebsiella Pneumoniae in Relation to Different Capsule Serotypes in Ningbo, China
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Jiang M, Zhang H, Lu W, Qiu X, Lin C, Zhao R, Li Q, and Wu Q
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klebsiella pneumoniae ,capsular serotypes ,virulence ,mlst ,Infectious and parasitic diseases ,RC109-216 - Abstract
Min Jiang,1,* Hui Zhang,2,* Wenjun Lu,3 Xuedan Qiu,1 Chenyao Lin,1 Rongqing Zhao,1 Qingcao Li,1 Qiaoping Wu1 1Clinical Laboratory, The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 2Clinical Laboratory, Ninghai County Chengguan Hospital, Ningbo, Zhejiang Province, People’s Republic of China; 3Intensive Care Units, The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qingcao Li; Qiaoping Wu, The Affiliated LiHuiLi Hospital of Ningbo University, 1111 Jiangnan Road, Ningbo, Zhejiang Province, 315040, People’s Republic of China, Tel +86-574-55835786, Fax +86-574-55835781, Email lqc_lab@163.com; lhlyywqp@163.comBackground: Klebsiella pneumoniae (KP) is a common nosocomial pathogen. Capsules are an important component of KP’s virulence, among which the K1, K2, K5, K20, K54, and K57 serotypes are predominant and exhibit varying degrees of virulence.Methods: The capsule and virulence genes of 150 carbapenem-resistant Klebsiella pneumoniae (CRKP) and 213 carbapenem-sensitive Klebsiella pneumoniae (CSKP) isolates were examined by polymerase chain reaction (PCR). The isolates were tested for hypermucoviscosity by string tests. Phylogenetic relationships between KP isolates were analyzed using multilocus sequence typing (MLST) and a Galleria mellonella infection model confirmed the differences in virulence.Results: A total of 111 of 363 isolates of KP were detected, the highest detected serotypes were K1, K5, and K2, and CSKP was detected more frequently than CRKP. There was a greater prevalence of K1 and K2 serotypes in CSKP, while in CRKP, K5 serotypes were more prevalent. K1 isolates had the highest detection rates for hypermucoviscosity Klebsiella pneumoniae (hmKP) and hypervirulent Klebsiella pneumoniae (hvKP), and carried the most virulence genes. K54 isolates had the lowest detection rate of hmKP while K5 isolates had the lowest detection rate of hvKP and carried the fewest virulence genes. MLST results for serotypes K1, K20, and K57 showed significant homogeneity, while those for serotypes K2, K5, and K54 showed diversity. The Galleria mellonella infection model showed that the K1 serotype was the most virulent and the K54 serotype was the weakest.Conclusion: CSKP isolates were detected more frequently than CRKP isolates for capsular serotype detection. K1 isolates had the most virulence gene and strongest virulence, K5 isolates carried the fewest virulence genes, and K54 isolates had the weakest virulence. Furthermore, significant homogeneity was observed among K1, K20, and K57 isolates.Keywords: Klebsiella pneumoniae, capsular serotypes, virulence, MLST
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- 2024
26. The Remarkable Anti-Breast Cancer Efficacy and Anti-Metastasis by Multifunctional Nanoparticles Co-Loading Squamocin, R848 and IR 780
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Wang X, Liu X, Guo Y, Gong T, Lu W, and Han M
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breast cancer ,multifunctional nanoparticle ,antitumor efficacy ,antimetastasis ,combined therapy. ,Medicine (General) ,R5-920 - Abstract
Xi Wang,1 Xinxin Liu,1 Yaoyao Guo,1,2 Tingting Gong,1 Wenmin Lu,1,3 Meihua Han,1 Yifei Guo,1 Xiangtao Wang1 1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, People’s Republic of China; 3College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Xiangtao Wang, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing, 100193, People’s Republic of China, Tel +86-10-57833266, Email xtaowang@163.comBackground: Breast cancer is a heterogeneous disease globally accounting for approximately 1 million new cases annually. Chemotherapy remains the main therapeutic option, but the antitumor efficacy needs to be improved.Methods: Two multifunctional nanoparticles were developed in this paper using oleic acid and mPEG2k-PCL2k as the drug carriers. Squamocin (Squ) was employed as a chemotherapeutic agent. Resiquimod (R848) or ginsenoside Rh2 was co-encapsulated in the nanoparticles to remold the immunosuppressive tumor microenvironment, and IR780 was coloaded as a photosensitizer to realize photothermal therapy.Results: The obtained Squ-R848-IR780 nanoparticles and Squ-Rh2-IR780 nanoparticles were uniformly spherical and approximately (162.200 ± 2.800) nm and (157.300 ± 1.1590) nm, respectively, in average diameter, with good encapsulation efficiency (above 85% for each drug), excellent stability in various physiological media and high photothermal conversion efficiency (24.10% and 22.58%, respectively). After intravenous administration, both nanoparticles quickly accumulated in the tumor and effectively enhanced the local temperature of the tumor to over 45 °C when irradiated by an 808 nm laser. At a low dose of 0.1 mg/kg, Squ nanoparticles treatment alone displayed a tumor inhibition rate of 55.28%, pulmonary metastasis inhibition rate of 59.47% and a mean survival time of 38 days, which were all higher than those of PTX injection (8 mg/kg) (43.64%, 25 days and 37.25%), indicating that Squ was a potent and effective antitumor agent. Both multifunctional nanoparticles, Squ-Rh2-IR780 nanoparticles and Squ-R848-IR780 nanoparticles, demonstrated even better therapeutic efficacy, with tumor inhibition rates of 90.02% and 97.28%, pulmonary metastasis inhibition rates of 95.42% and 98.09, and mean survival times of 46 days and 52 days, respectively.Conclusion: The multifunctional nanoparticles coloaded with squamocin, R848 and IR 780 achieved extraordinary therapeutic efficacy and excellent antimetastasis activity and are thus promising in the future treatment of breast tumors and probably other tumors.Keywords: breast cancer, multifunctional nanoparticle, antitumor efficacy, antimetastasis, combined therapy
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- 2024
27. Association Between Hemoglobin-Albumin-Lymphocyte-Platelet Index and Mortality in Hospitalized COVID-19 Omicron BA.2 Infected Patients
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Wu W, Lu W, Hong D, Yu X, and Xiong L
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biomarkers ,covid-19 ,hemoglobin-albumin-lymphocyte-platelet index ,mortality ,omicron ba.2 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Wei Wu,1– 4,* Wenbin Lu,5,* Dongmei Hong,1– 4 Xiya Yu,1– 4 Lize Xiong1– 4 1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 3Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 4Clinical Research Centre for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 5Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiya Yu; Lize Xiong, Tel +86-21-55603999 ; +86-21-55603002, Fax +86-21-56660851, Email yuxiyash@163.com; mzkxlz@126.com; lizexiong@tongji.edu.cnBackground: The hemoglobin-albumin-lymphocyte-platelet (HALP) index is a novel biomarker reflecting systemic inflammation and nutritional status which are important for coronavirus disease 2019 (COVID-19) mortality. However, the association between HALP and mortality in patients with COVID-19 has yet to be investigated.Methods: A cohort of COVID-19 Omicron BA.2 infected patients admitted to the Shanghai Fourth People’s Hospital, School of Medicine, Tongji University from April 12, 2022 to June 17, 2022 was retrospectively analyzed. Laboratory examinations on hospital admission, including hemoglobin, albumin, and lymphocyte and platelet, were collected. The association between baseline HALP and in-hospital poor overall survival (OS) was assessed using Kaplan–Meier curves, Cox regression models, interaction, and stratified analyses.Results: A total of 2147 patients with COVID-19 Omicron BA.2 infection were included in the final analyses, and mortality in the hospital was 2.65%. Multivariate analysis indicated that low HALP index was independently associated with in-hospital mortality of COVID-19 patients [hazard ratio (HR) = 2.08; 95% confidence interval (CI) = 1.17– 3.73]. Subgroup analysis demonstrated that low HALP index was an independent risk factor for in-hospital mortality in COVID-19 patients with age ≥ 70 (HR = 2.22, CI = 1.18– 4.15) and severe cases (HR = 2.09, CI = 1.13– 3.86).Conclusion: HALP index is independently related to in-hospital poor OS for COVID-19 Omicron BA.2 infected patients, especially for age ≥ 70 and severe cases. HALP index on hospital admission is a useful candidate biomarker for identifying high risk of mortality in COVID-19 Omicron BA.2 infected patients.Keywords: biomarkers, COVID-19, hemoglobin-albumin-lymphocyte-platelet index, mortality, Omicron BA.2
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- 2024
28. Expedition 390/393 methods
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Coggon, R.M., primary, Teagle, D.A.H., additional, Sylvan, J.B., additional, Reece, J., additional, Estes, E.R., additional, Williams, T.J., additional, Christeson, G.L., additional, Aizawa, M., additional, Albers, E., additional, Amadori, C., additional, Belgrano, T.M., additional, Borrelli, C., additional, Bridges, J.D., additional, Carter, E.J., additional, D'Angelo, T., additional, Dinarès-Turell, J., additional, Doi, N., additional, Estep, J.D., additional, Evans, A., additional, Gilhooly III, W.P., additional, Grant, L.J.C., additional, Guérin, G.M., additional, Harris, M., additional, Hojnacki, V.M., additional, Hong, G., additional, Jin, X., additional, Jonnalagadda, M., additional, Kaplan, M.R., additional, Kempton, P.D., additional, Kuwano, D., additional, Labonte, J.M., additional, Lam, A.R., additional, Latas, M., additional, Lowery, C.M., additional, Lu, W., additional, McIntyre, A., additional, Moal-Darrigade, P., additional, Pekar, S.F., additional, Robustelli Test, C., additional, Routledge, C.M., additional, Ryan, J.G., additional, Santiago Ramos, D., additional, Shchepetkina, A., additional, Slagle, A.L., additional, Takada, M., additional, Tamborrino, L., additional, Villa, A., additional, Wang, Y., additional, Wee, S.Y., additional, Widlansky, S.J., additional, Yang, K., additional, Kurz, W., additional, Prakasam, M., additional, Tian, L., additional, Yu, T., additional, and Zhang, G., additional
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- 2024
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29. Site U1560
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Teagle, D.A.H., primary, Reece, J., additional, Williams, T.J., additional, Coggon, R.M., additional, Sylvan, J.B., additional, Estes, E.R., additional, Christeson, G.L., additional, Albers, E., additional, Amadori, C., additional, Belgrano, T.M., additional, D'Angelo, T., additional, Doi, N., additional, Evans, A., additional, Guérin, G.M., additional, Harris, M., additional, Hojnacki, V.M., additional, Hong, G., additional, Jin, X., additional, Jonnalagadda, M., additional, Kuwano, D., additional, Labonte, J.M., additional, Lam, A.R., additional, Latas, M., additional, Lu, W., additional, Moal-Darrigade, P., additional, Pekar, S.F., additional, Robustelli Test, C., additional, Ryan, J.G., additional, Santiago Ramos, D., additional, Shchepetkina, A., additional, Villa, A., additional, Wee, S.Y., additional, Widlansky, S.J., additional, Aizawa, M., additional, Borrelli, C., additional, Bridges, J.D., additional, Carter, E.J., additional, Dinarès-Turell, J., additional, Estep, J.D., additional, Gilhooly III, W.P., additional, Grant, L.J.C., additional, Kaplan, M.R., additional, Kempton, P.D., additional, Lowery, C.M., additional, McIntyre, A., additional, Routledge, C.M., additional, Slagle, A.L., additional, Takada, M., additional, Tamborrino, L., additional, Wang, Y., additional, Yang, K., additional, Kurz, W., additional, Prakasam, M., additional, Tian, L., additional, Yu, T., additional, and Zhang, G., additional
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- 2024
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30. Site U1556
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Coggon, R.M., primary, Sylvan, J.B., additional, Estes, E.R., additional, Teagle, D.A.H., additional, Reece, J., additional, Williams, T.J., additional, Christeson, G.L., additional, Aizawa, M., additional, Borrelli, C., additional, Bridges, J.D., additional, Carter, E.J., additional, Dinarès-Turell, J., additional, Estep, J.D., additional, Gilhooly III, W.P., additional, Grant, L.J.C., additional, Kaplan, M.R., additional, Kempton, P.D., additional, Lowery, C.M., additional, McIntyre, A., additional, Routledge, C.M., additional, Slagle, A.L., additional, Takada, M., additional, Tamborrino, L., additional, Wang, Y., additional, Yang, K., additional, Albers, E., additional, Amadori, C., additional, Belgrano, T.M., additional, D'Angelo, T., additional, Doi, N., additional, Evans, A., additional, Guérin, G.M., additional, Harris, M., additional, Hojnacki, V.M., additional, Hong, G., additional, Jin, X., additional, Jonnalagadda, M., additional, Kuwano, D., additional, Labonte, J.M., additional, Lam, A.R., additional, Latas, M., additional, Lu, W., additional, Moal-Darrigade, P., additional, Pekar, S.F., additional, Robustelli Test, C., additional, Ryan, J.G., additional, Santiago Ramos, D., additional, Shchepetkina, A., additional, Villa, A., additional, Wee, S.Y., additional, Widlansky, S.J., additional, Kurz, W., additional, Prakasam, M., additional, Tian, L., additional, Yu, T., additional, and Zhang, G., additional
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- 2024
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31. Expedition 390/393 summary
- Author
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Coggon, R.M., primary, Teagle, D.A.H., additional, Sylvan, J.B., additional, Reece, J., additional, Estes, E.R., additional, Williams, T.J., additional, Christeson, G.L., additional, Aizawa, M., additional, Albers, E., additional, Amadori, C., additional, Belgrano, T.M., additional, Borrelli, C., additional, Bridges, J.D., additional, Carter, E.J., additional, D'Angelo, T., additional, Dinarès-Turell, J., additional, Doi, N., additional, Estep, J.D., additional, Evans, A., additional, Gilhooly III, W.P., additional, Grant, L.J.C., additional, Guérin, G.M., additional, Harris, M., additional, Hojnacki, V.M., additional, Hong, G., additional, Jin, X., additional, Jonnalagadda, M., additional, Kaplan, M.R., additional, Kempton, P.D., additional, Kuwano, D., additional, Labonte, J.M., additional, Lam, A.R., additional, Latas, M., additional, Lowery, C.M., additional, Lu, W., additional, McIntyre, A., additional, Moal-Darrigade, P., additional, Pekar, S.F., additional, Robustelli Test, C., additional, Routledge, C.M., additional, Ryan, J.G., additional, Santiago Ramos, D., additional, Shchepetkina, A., additional, Slagle, A.L., additional, Takada, M., additional, Tamborrino, L., additional, Villa, A., additional, Wang, Y., additional, Wee, S.Y., additional, Widlansky, S.J., additional, Yang, K., additional, Kurz, W., additional, Prakasam, M., additional, Tian, L., additional, Yu, T., additional, and Zhang, G., additional
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- 2024
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32. List of contributors
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Abreu, J.C. Batista, primary, Arjunan, Arun, additional, Camotim, Dinar, additional, Chen, H., additional, Degtyarev, V.V., additional, Dinis, Pedro Borges, additional, Hancock, G.J., additional, Hennis, Dana, additional, Hrico, Nick, additional, Leng, Jiazhen, additional, Li, Zhanjie, additional, Li, Y., additional, Lim, J.B.P., additional, Lu, W., additional, Madhavan, M., additional, Mahaffey, Riley, additional, Martins, André Dias, additional, Mynors, Diane, additional, Nethercot, D.A., additional, Pham, C.H., additional, Rahman, Nabil A., additional, Selvaraj, S., additional, Wang, Chang Jiang, additional, Williams, L.W., additional, Wrzesien, A.M., additional, Xu, L., additional, Yu, C., additional, and Zhang, W., additional
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- 2024
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33. Sustainable applications of cold-formed steel structures
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Lu, W., primary
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- 2024
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34. N\'eel Spin Currents in Antiferromagnets
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Shao, Ding-Fu, Jiang, Yuan-Yuan, Ding, Jun, Zhang, Shu-Hui, Wang, Zi-An, Xiao, Rui-Chun, Gurung, Gautam, Lu, W. J., Sun, Y. P., and Tsymbal, Evgeny Y.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Ferromagnets are known to support spin-polarized currents that control various spin-dependent transport phenomena useful for spintronics. On the contrary, fully compensated antiferromagnets are expected to support only globally spin-neutral currents. Here, we demonstrate that these globally spin-neutral currents can represent the N\'eel spin currents, i.e. staggered spin currents flowing through different magnetic sublattices. The N\'eel spin currents emerge in antiferromagnets with strong intra-sublattice coupling (hopping) and drive the spin-dependent transport phenomena such as tunneling magnetoresistance (TMR) and spin-transfer torque (STT) in antiferromagnetic tunnel junctions (AFMTJs). Using RuO$_{2}$ and Fe$_{4}$GeTe$_{2}$ as representative antiferromagnets, we predict that the N\'eel spin currents with a strong staggered spin-polarization produce a sizable field-like STT capable of the deterministic switching of the N\'eel vector in the associated AFMTJs. Our work uncovers the previously unexplored potential of fully compensated antiferromagnets and paves a new route to realize the efficient writing and reading of information for antiferromagnetic spintronics.
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- 2022
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35. Spin-Neutral Tunneling Anomalous Hall Effect
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Shao, Ding-Fu, Zhang, Shu-Hui, Xiao, Rui-Chun, Wang, Zi-An, Lu, W. J., Sun, Y. P., and Tsymbal, Evgeny Y.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Anomalous Hall effect (AHE) is a fundamental spin-dependent transport property that is widely used in spintronics. It is generally expected that currents carrying net spin polarization are required to drive the AHE. Here we demonstrate that, in contrast to this common expectation, a spin-neutral tunneling AHE (TAHE), i.e. a TAHE driven by spin-neutral currents, can be realized in an antiferromagnetic (AFM) tunnel junction where an AFM electrode with a non-spin-degenerate Fermi surface and a normal metal electrode are separated by a non-magnetic barrier with strong spin-orbit coupling (SOC). The symmetry mismatch between the AFM electrode and the SOC barrier results in an asymmetric spin-dependent momentum filtering of the spin-neutral longitudinal current generating the transverse Hall current in each electrode. We predict a sizable spin-neutral TAHE in an AFM tunnel junction with a RuO$_{2}$-type AFM electrode and a SnTe-type SOC barrier and show that the Hall currents are reversible by the N\'eel vector switching. With the Hall angle being comparable to that in conventional AHE bulk materials, the predicted spin-neutral TAHE can be used for the N\'eel vector detection in antiferromagnetic spintronics.
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- 2022
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36. Association Between Metabolic Dysfunction-Associated Fatty Liver Disease and MACCEs in Patients with Diabetic Foot Ulcers: An Ambispective Longitudinal Cohort Study
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Huang X, Li Z, Zhai Z, Wang Q, Wei R, Mo J, Huang J, and Lu W
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diabetic foot ulcers ,peripheral arterial disease ,metabolic dysfunction-associated fatty liver disease ,major adverse cardiac and cerebral events ,Specialties of internal medicine ,RC581-951 - Abstract
Xiuxian Huang,1,* Zhengming Li,1,* Zhenwei Zhai,1,* Qiu Wang,1 Rongyan Wei,1 Jiacheng Mo,2 Jianhao Huang,1 Wensheng Lu1,* 1Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China; 2Information Network Center of Guangxi Academy of Medical Sciences, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wensheng Lu, Email lwswxqz@163.comAim: Metabolic dysfunction-related fatty liver disease (MAFLD) is closely related to metabolic disorders. However, the relationship between MAFLD and the prognosis in diabetic foot ulcers (DFUs) remains unclear. This study aimed to explore the association between MAFLD and the risk of major adverse cardiac and cerebral events (MACCEs) in patients with DFUs.Methods: 889 inpatients with DFUs (PEDIS/TEXAS mild and above) were included in this study from 2013 to 2023. All participants were placed into non-MAFLD (n = 643) and MAFLD (n = 246) groups and followed up every 6 months for 10.9 years with a median of 63 months through in-person outpatient interviews and family fixed-line telephone visits. The association between MAFLD and the risk of MACCEs was evaluated through Multivariate Cox regression analyses, Stratified analyses and Kaplan-Meier survival analyses.Results: Of the 889 subjects, 214 (24.07%) experienced MACCEs. Multivariate Cox regression analysis showed that MAFLD was independently associated with MACCEs (P < 0.001), of which with non-fatal myocardial infarction (P = 0.04), non-fatal stroke (P = 0.047), coronary artery revascularization (P = 0.002), heart failure (P = 0.029), and all-cause mortality (P = 0.021), respectively. The stratified analysis revealed that compared with non-MAFLD (HR=1), DFUs with MAFLD had a 2.64-fold increased risk for MACCEs (P < 0.001; P for interaction = 0.001) in peripheral arterial disease (PAD) subgroup. Kaplan-Meier analysis evidenced that the MAFLD group had a higher cumulative incidence of MACCEs (log-rank, all P < 0.05).Conclusion: MAFLD is a high-risk factor for MACCEs in patients with DFUs. The findings will remind clinicians to pay more attention to MAFLD in patients with DFUs, especially in patients with DFUs combined with PAD as early as possible in clinical practice and adopt timely effective intervention strategies to prevent the occurrence of MACCEs to improve the clinical prognosis in patients with DFUs.Keywords: diabetic foot ulcers, peripheral arterial disease, metabolic dysfunction-associated fatty liver disease, major adverse cardiac and cerebral events
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- 2024
37. Real-Time Experience of Abrocitinib for the Treatment of Mucous Membrane Pemphigoid: A Case Report
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Teng Y, Ren M, Yang X, Lu W, and Tao X
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abrocitinib ,mucous membrane pemphigoid ,jak inhibitor ,Medicine (General) ,R5-920 - Abstract
Yan Teng, Mingyang Ren, Xianhong Yang, Wei Lu, Xiaohua Tao Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, 310014, People’s Republic of ChinaCorrespondence: Xiaohua Tao, Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital of Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China, Tel +86-13505811700, Email taoxiaohua@hmc.edu.cnBackground: Mucous membrane pemphigoid (MMP), a rare autoimmune vesiculous and erosive disorder, may affect multiple mucous membranes, with the oral cavity being the most commonly affected site. Its treatment depends on the site(s) of mucosal involvement and disease severity.Patients and Methods: A 62-year-old female patient with MMP that predominantly involved the oral cavity strongly rejected systemic corticosteroid or immunosuppressive agents and was successfully treated with abrocitinib, a highly selective JAK-1 inhibitor with a good safety profile.Results: The case demonstrated good efficacy and safety profile of abrocitinib for the treatment of MMP with predominant oral involvement.Conclusion: Abrocitinib is a promising agent for the treatment of MMP with oral involvement.Keywords: abrocitinib, mucous membrane pemphigoid, JAK inhibitor
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- 2024
38. The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study
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Tan Y, Li Y, Huang X, Zhai Z, Wang Q, Guo Y, Li J, and Lu W
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sepsis ,red blood cell distribution width ,albumin ,rehospitalization ,rehospitalization all-cause mortality ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Yanni Tan,1,* Yameng Li,2,* Xiuxian Huang,3,* Zhenwei Zhai,3,* Qiu Wang,3,* Yanli Guo,4 Junjun Li,5 Wensheng Lu3,* 1Department of Endocrinology and Respiratory of the Third People’s Hospital of Nanning, Nanning, Guangxi, 530003, People’s Republic of China; 2Medical Department of Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China; 3Department of Endocrinology and Metabolism of Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China; 4Yuncheng Vocational and Technical University, Yuncheng, Shanxi, 044000, People’s Republic of China; 5Hospital Dean’s Office of Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wensheng Lu, Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, No. 6, Taoyuan Road, Nanning, Guangxi, 530021, People’s Republic of China, Email Lwswxqz@163.com Junjun Li, Hospital Dean’s Office of Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, No. 6, Taoyuan Road, Nanning, Guangxi, 530021, People’s Republic of China, Email lijunjun6225@163.comObjective: To explore the relationship between red blood cell distribution width to albumin (RDW/ALB) ratio (RAR) and the risk of rehospitalization and rehospitalization all-cause mortality in middle-aged and elderly survivors with sepsis based on an ambispective longitudinal cohort from the Intensive Care Unit (ICU).Methods: Between 2017 and 2022, 455 adults who survived the first-episode severe sepsis without recurrence for at least 3 months were included in this study. All participants were followed up every 4 weeks for 12 months. According to the tertiles of RAR, participants were divided into three groups: low-level (≤ 0.36, n = 152), moderate-level (0.37– 0.44, n = 152), and high-level (≥ 0.45, n = 151). The relationship between RAR and the risk of rehospitalization and rehospitalization all-cause mortality was evaluated.Results: Out of 455 participants, 156 experienced rehospitalization (34.3%), of which 44 (28.2%) died. Receiver operating characteristic (ROC) analysis showed that the RAR cut-off values for rehospitalization and rehospitalization all-cause mortality were 0.4251 and 0.4743, respectively. Multivariate Cox regression analysis indicated that the RAR was positively associated with rehospitalization (P = 0.011) and all-cause mortality (P = 0.006). Compared with the low-level, the high-level RAR presented a higher dose-dependent rehospitalization risk (P = 0.02) and rehospitalization all-cause mortality (P = 0.044). The stratified analysis displayed that compared to the low-level, with the RAR increasing by 1.0, the risk for rehospitalization increased 3.602-fold in aged < 65 patients (P = 0.002) and 1.721-fold in female patients (P = 0.014). Kaplan–Meier survival analysis implied a significant positive association between the RAR and the cumulative incidence of rehospitalization and rehospitalization all-cause mortality (log-rank, all P < 0.001).Conclusion: RAR has a reliable predictive value for the risk of rehospitalization and rehospitalization all-cause mortality in patients with sepsis. Consequently, monitoring RAR for at least 1 year after surviving sepsis in female patients aged < 65 in clinical practice is critical.Keywords: sepsis, red blood cell distribution width, albumin, rehospitalization, rehospitalization all-cause mortality
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- 2024
39. Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS
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Lei P, Shen W, Tang H, You L, Chen G, Tang Y, and Lu W
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adagrasib ,uplc-ms/ms ,pharmacokinetics ,tissue distribution ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Pan Lei,1,2 Wanying Shen,2 Huijuan Tang,2 Li You,2 Guoyi Chen,2 Yijun Tang,1 Wei Lu3 1Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People’s Republic of China; 2Hubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of China; 3Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, People’s Republic of ChinaCorrespondence: Yijun Tang, Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, People’s Republic of China, Email tyj_799@taihehospital.com Wei Lu, Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, People’s Republic of China, Email luwei0903@taihehospital.comPurpose: Adagrasib is a selective and reversible inhibitor of KRAS G12C, which significantly delays the progression of solid tumors. However, the absorption, distribution, metabolism, and excretion of adagrasib in vivo are unclear. This study explores the absorption and distribution of adagrasib in vivo.Methods: An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UPLC-MS/MS) method was established for the determination of adagrasib in the rat plasma and tissue. Sprague-Dawley rats were intravenous administrated (5 mg/kg) and oral administrated (30 mg/kg) with adagrasib, and the plasma concentration of adagrasib was determined. After single oral administration of adagrasib (30 mg/kg), the heart, liver, spleen, lung, kidney, intestine, and pancreas were excised. The organs were homogenized with saline solution, and the concentration of adagrasib in tissues was determined.Results: The intra- and inter-day accuracy were from 84.90% to 113.47%, and the precision was within ± 15%. The matrix effect and recovery were within ± 15%. The maximum plasma concentration (Cmax) of adagrasib was 677.45 ± 58.72 ng/mL. The elimination half-life time (t1/2) was 3.50 ± 0.21 h after oral administration and 2.08 ± 0.54 h after intravenous administration. The oral bioavailability was 50.72%. The highest concentrations of adagrasib in liver was 5047.80 ± 676.48 ng/g at 2 h after administration, and it was still detectable at 24 hours after administration.Conclusion: Adagrasib was slowly absorbed and cleared rapidly, and it was also widely distributed in vivo. This study provides a potential reference for adagrasib in clinical studies.Keywords: adagrasib, UPLC-MS/MS, pharmacokinetics, tissue distribution
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- 2024
40. The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China
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Chen T, Wu S, Feng L, Long S, Liu Y, Lu W, Chen W, Hong G, Zhou L, Wang F, Luo Y, and Zou H
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hdl subclass ,insulin resistance ,metabolic syndrome ,normal hdl-c population. ,Specialties of internal medicine ,RC581-951 - Abstract
Tong Chen,1– 3 Shiquan Wu,1 Ling Feng,4 SiYu Long,1 Yu Liu,1,2 WenQian Lu,5 Wenya Chen,1 Guoai Hong,1 Li Zhou,1 Fang Wang,1 Yuechan Luo,1 Hequn Zou1,3,5 1Department of Nephrology, South China Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, People’s Republic of China; 3Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 4Department of Nephrology, Shenzhen Hospital, Southern Medical University, Shenzhen, People’s Republic of China; 5Department of Medicine, The Chinese University of Hong Kong, Shenzhen, People’s Republic of ChinaCorrespondence: Hequn Zou, School of Medicine, The Chinese University of Hong Kong, Shenzhen, People’s Republic of China, Email zouhequn@cuhk.edu.cnBackground: The annual prevalence of metabolic syndrome (MetS) is increasing. Therefore, early screening and recognition of MetS are critical. This study aimed to evaluate the association between high-density lipoprotein (HDL) subclasses and MetS and to examine whether they could serve as early indicators in a Chinese community-based population with normal high-density lipoprotein cholesterol (HDL-C) levels.Methods: We used microfluidic chip technology to measure HDL subclasses in 463 people with normal HDL levels in 2018. We assessed how HDL subclasses correlated with and predicted insulin resistance (IR) and metabolic syndrome (MetS), evaluated by homeostatic model insulin resistance index (HOMA-IR) and the 2009 International Diabetes Federation (IDF), the American Heart Association (AHA), and the National Heart, Lung, and Blood Institute (NHLBI) criteria, respectively. We used correlation tests and ROC curves for the analysis.Results: The results indicate that there was a negative association between HDL2b% and the risk of IR and MetS in both sexes. Subjects in the highest quartile of HDL2b% had a significantly lower prevalence of IR and MetS than those in the lowest quartile (P< 0.01). Correlation analysis between HDL2b% and metabolic risk factors showed that HDL2b% had a stronger association with these factors than HDL-C did in both sexes. ROC curve analysis also showed that HDL2b% had significant diagnostic value for IR and MetS compared to other lipid indicators.Conclusion: This study showed that MetS alters the distribution of HDL subclasses even when HDL-C levels are within the normal range. HDL-2b% has better diagnostic value for IR and MetS than HDL-C alone and may be a useful marker for early screening.Keywords: HDL subclass, insulin resistance, metabolic syndrome, normal HDL-C population
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- 2024
41. Nano-Drug Delivery Systems Based on Natural Products
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Lv Y, Li W, Liao W, Jiang H, Liu Y, Cao J, Lu W, and Feng Y
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natural products ,nanotechnology ,drug delivery ,targeting ,Medicine (General) ,R5-920 - Abstract
Ying Lv, Wenqing Li, Wei Liao, Haibo Jiang, Yuwei Liu, Jiansheng Cao, Wenfei Lu, Yufei Feng Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People’s Republic of ChinaCorrespondence: Yufei Feng, 150040, Tel +86-18503653988, Email fuf-002@163.comAbstract: Natural products have proven to have significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, and treatment. Compared with synthetic drugs, natural products not only have diverse structures but also exhibit a range of biological activities against different disease states and molecular targets, making them attractive for development in the field of medicine. Despite advancements in the use of natural products for clinical purposes, there remain obstacles that hinder their full potential. These challenges include issues such as limited solubility and stability when administered orally, as well as short durations of effectiveness. To address these concerns, nano-drug delivery systems have emerged as a promising solution to overcome the barriers faced in the clinical application of natural products. These systems offer notable advantages, such as a large specific surface area, enhanced targeting capabilities, and the ability to achieve sustained and controlled release. Extensive in vitro and in vivo studies have provided further evidence supporting the efficacy and safety of nanoparticle-based systems in delivering natural products in preclinical disease models. This review describes the limitations of natural product applications and the current status of natural products combined with nanotechnology. The latest advances in nano-drug delivery systems for delivery of natural products are considered from three aspects: connecting targeting warheads, self-assembly, and co-delivery. Finally, the challenges faced in the clinical translation of nano-drugs are discussed. Keywords: natural products, nanotechnology, drug delivery, targeting
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- 2024
42. Field-induced Topological Hall effect in antiferromagnetic axion insulator candidate EuIn$_2$As$_2$
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Yan, J., Jiang, Z. Z., Xiao, R. C., Lu, W. J., Song, W. H., Zhu, X. B., Luo, X., Sun, Y. P., and Yamashita, M.
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Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
The magnetic topological materials have attracted significant attention due to their potential realization of variety of novel quantum phenomena. EuIn$_2$As$_2$ has recently been theoretically recognized as a long awaited intrinsic antiferromagnetic bulk axion insulator. However, the experimental study on transport properties arising from the topological states in this material is scarce. In this paper, we perform the detailed magnetoresistance (MR) and Hall measurements to study the magnetotransport properties of this material. We find that the transport is strongly influenced by the spin configuration of the Eu moments from the concomitant change in the field dependence of the MR and that of the magnetization below the N\'eel temperature. Most importantly, an anomalous Hall effect (AHE) and a large topological Hall effect (THE) are observed. We suggest that the AHE is originated from a nonvanishing net Berry curvature due to the helical spin structure and that the THE is attributed to the formation of a noncoplanar spin texture with a finite scalar spin chirality induced by the external magnetic field in EuIn$_2$As$_2$. Our studies provide a platform to understand the influence of the interplay between the topology of electronic bands and the field-induced magnetic structure on magnetoelectric transport properties. In addition, our observations give a hint to realize axion insulator states and high-order topological insulator states through manipulating the magnetic state of EuIn$_2$As$_2$., Comment: 7 pages, 4 figures, accepted by Physical Review Reaseach
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- 2022
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43. European Strategy for Particle Physics -- Accelerator R&D Roadmap
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Adolphsen, C., Angal-Kalinin, D., Arndt, T., Arnold, M., Assmann, R., Auchmann, B., Aulenbacher, K., Ballarino, A., Baudouy, B., Baudrenghien, P., Benedikt, M., Bentvelsen, S., Blondel, A., Bogacz, A., Bossi, F., Bottura, L., Bousson, S., Brüning, O., Brinkmann, R., Bruker, M., Brunner, O., Burrows, P. N., Burt, G., Calatroni, S., Cassou, K., Castilla, A., Catalan-Lasheras, N., Cenni, E., Chancé, A., Colino, N., Corde, S., Corner, L., Cros, B., Cross, A., Delahaye, J. P., Devanz, G., Etienvre, A. -I., Evtushenko, P., Faus-Golfe, A., Fazilleau, P., Ferrario, M., Gallo, A., García-Tabarés, L., Geddes, C., Gerigk, F., Gianotti, F., Gilardoni, S., Grudiev, A., Gschwendtner, E., Hoffstaetter, G., Hogan, M., Hooker, S., Hutton, A., Ischebeck, R., Jakobs, K., Janot, P., Jensen, E., Kühn, J., Kaabi, W., Kayran, D., Klein, M., Knobloch, J., Koratzinos, M., Kuske, B., Lamont, M., Latina, A., Lebrun, P., Leemans, W., Li, D., Long, K., Longuevergne, D., Losito, R., Lu, W., Lucchesi, D., Lundh, O., Métral, E., Marhauser, F., Michizono, S., Militsyn, B., Mnich, J., Montesinos, E., Mounet, N., Muggli, P., Musumeci, P., Nagaitsev, S., Nakada, T., Neumann, A., Newbold, D., Nghiem, P., Noe, M., Oide, K., Osterhoff, J., Palmer, M., Pastrone, N., Pietralla, N., Prestemon, S., Previtali, E., Proslier, T., Quettier, L., Raubenheimer, T., Rimmer, B., Rivkin, L., Rochepault, E., Rogers, C., Rosaz, G., Roser, T., Rossi, L., Ruber, R., Schulte, D., Seidel, M., Senatore, C., Shepherd, B., Shi, J., Shipman, N., Specka, A., Stapnes, S., Stocchi, A., Stratakis, D., Syratchev, I., Tanaka, O., Tantawi, S., Tennant, C., Tsesmelis, E., Vaccarezza, C., Valente, A. -M., Védrine, P., Vieira, J., Vinokurov, N., Weise, H., Wenskat, M., Williams, P., Wing, M., Yamamoto, A., Yamamoto, Y., Yokoya, K., and Zimmermann, F.
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
The 2020 update of the European Strategy for Particle Physics emphasised the importance of an intensified and well-coordinated programme of accelerator R&D, supporting the design and delivery of future particle accelerators in a timely, affordable and sustainable way. This report sets out a roadmap for European accelerator R&D for the next five to ten years, covering five topical areas identified in the Strategy update. The R&D objectives include: improvement of the performance and cost-performance of magnet and radio-frequency acceleration systems; investigations of the potential of laser / plasma acceleration and energy-recovery linac techniques; and development of new concepts for muon beams and muon colliders. The goal of the roadmap is to document the collective view of the field on the next steps for the R&D programme, and to provide the evidence base to support subsequent decisions on prioritisation, resourcing and implementation., Comment: 270 pages, 58 figures. Editor: N. Mounet. LDG chair: D. Newbold. Panel chairs: P. V\'edrine (HFM), S. Bousson (RF), R. Assmann (plasma), D. Schulte (muon), M. Klein (ERL). Panel editors: B. Baudouy (HFM), L. Bottura (HFM), S. Bousson (RF), G. Burt (RF), R. Assmann (plasma), E. Gschwendtner (plasma), R. Ischebeck (plasma), C. Rogers (muon), D. Schulte (muon), M. Klein (ERL)
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- 2022
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44. Diagnostic and prognostic value of parameters of erector spinae in patients with uremic sarcopenia
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Yuan, M., Jiang, L., Sun, C., Lu, W., Tapu, S.R., Zhang, H., Jing, G., Weng, H., and Peng, J.
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- 2024
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45. Inspired in Adversity: How Inspiration Mediates the Effects of Emotions on Coping Strategies
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Hao J, Lu W, Gong W, and Chen X
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covid-19 ,coping ,inspiration ,emotions ,Psychology ,BF1-990 ,Industrial psychology ,HF5548.7-5548.85 - Abstract
Jia Hao,1 Weijian Lu,2 Wanqi Gong,3 Xiaoxi Chen4 1School of English for International Business, Guangdong University of Foreign Studies, Guangzhou, People’s Republic of China; 2School of Business and Economics, Maastricht University, Maastricht, Netherlands; 3School of Journalism and Communication, Guangdong University of Foreign Studies, Guangzhou, People’s Republic of China; 4School of Management, Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Wanqi Gong, School of Journalism and Communication, Guangdong University of Foreign Studies, No. 1689 Bai Yun Avenue, Guangzhou, 510420, People’s Republic of China, Tel +86 20 39328095, Email yunkigong@gmail.comPurpose: Inspiration is a psychological construct that has been relatively understudied in times of difficulty. This study aims to investigate the mediating effect of inspiration on the relationship between emotions and coping strategies in the context of adversity and to testify the effect in Chinese as well as the International societies.Participants and Methods: Using the snowball sampling method, two survey studies were conducted among 523 Chinese and 503 international participants during and soon after the local Covid-19 outbreak to testify how positive and negative emotions contributed to various coping strategies and whether the experience of inspiration mediated these relations. Structural equation modeling (SEM) was used to analyze the data.Results: Positive emotions had a higher impact on problem-solving and seeking social support coping strategies, whereas negative emotions had a higher impact on avoidance coping strategy. Both positive and negative emotions had positive relationships with inspiration, but positive emotions had a higher impact than negative ones. The indirect effects of emotions on problem-solving and social support coping strategies through inspiration were significantly positive, while the avoidance coping strategy was not influenced by the experience of inspiration.Conclusion: The results suggest that being inspired in both positive and negative emotions is positively related to approach coping strategies in adverse situations such as COVID-19, with the effect patterns slightly differing between Chinese participants and their Western counterparts. This study highlights the importance of inspiration experience as a motivational state that can help individuals bring newly acquired ideas into fruition, especially during times of difficulty. By understanding the role of inspiration in the context of adversity, public health systems can better assist individuals in different societies to cope with the challenges they face.Keywords: COVID-19, coping, inspiration, emotions
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- 2023
46. The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study
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Lu W, Lin S, Wang C, Jin P, and Bian J
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geriatric ,hip arthroplasty ,neutrophil to lymphocyte ratio ,postoperative delirium ,platelet to lymphocyte ratio ,systemic inflammation response index ,Medicine (General) ,R5-920 - Abstract
Wenbin Lu,* Shengwei Lin,* Cheng Wang, Peipei Jin, Jinjun Bian Faculty of Anesthesiology, Changhai Hospital, Naval Medical University/Second Military Medical University, PLA, Shanghai, 200433, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peipei Jin; Jinjun Bian, Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, 168, Changhai Road, Shanghai, 200433, People’s Republic of China, Tel/Fax +86-021-31161886 ; +86-021-31161841, Email kingpei89@163.com; jinjunbicu@163.comPurpose: To explore the relationship between the systemic inflammation response index (SIRI) and postoperative delirium (POD) in older patients with hip arthroplasty surgery.Patients and Methods: Older patients who underwent elective hip arthroplasty surgery were included in this retrospective study. SIRI, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were collected from blood routine examination at admission. Binary logistic regression analysis was performed to evaluate the association between SIRI levels and POD was analyzed.Results: Ultimately, 116 older patients who met the inclusion criteria were assessed. Thirty-four (29%) of 116 patients diagnosed with POD were defined as the POD group, and the rest consisted of the Non-POD group. Compared with non-POD patients, POD patients showed significantly higher levels of SIRI (P < 0.001) and NLR (P = 0.002) at admission. There was no significance in the levels of PLR between two groups. SIRI was independently associated with the occurrence of POD in multivariate logistic regression analysis [odds ratio (OR) = 3.34, 95% confidence interval (95% CI) = 1.26– 8.85, P = 0.016]. Receiver operating characteristic curve analysis indicated that SIRI with an optimal cutoff value of 0.987 predicted the POD with a sensitivity of 88.2% and specificity of 74.4%, and the area under the curve was 0.82 (95% CI, 0.74– 0.90, P < 0.01).Conclusion: Preoperative SIRI and NLR levels in the blood are associated with the occurrence of POD. Moreover, preoperative SIRI level is a useful candidate biomarker to identify delirium after elective hip arthroplasty surgery in older patients.Keywords: geriatric, hip arthroplasty, neutrophil to lymphocyte ratio, postoperative delirium, platelet to lymphocyte ratio, systemic inflammation response index
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- 2023
47. Successful Treatment of Granulomatous Rosacea by JAK Inhibitor Abrocitinib: A Case Report
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Ren M, Yang X, Teng Y, Lu W, Ding Y, and Tao X
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jak inhibitor ,granulomatous rosacea ,abrocitinib ,efficacy ,Dermatology ,RL1-803 - Abstract
Mingyang Ren,1 Xianhong Yang,2 Yan Teng,2 Wei Lu,2 Yang Ding,2 Xiaohua Tao2 1Department of Graduate School, Bengbu Medical College, Bengbu, People’s Republic of China; 2Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, People’s Republic of ChinaCorrespondence: Xiaohua Tao, Email txhtxh@sina.comAbstract: Granulomatous rosacea (GR) is a rare inflammatory skin disease characterized by persistent, hard, yellow, brown, red, or flesh-colored papules, plaques, or nodules on the face. Limited data are available on patients treated for GR, with only case reports and case series published. Herein, we describe the case of a 53-year-old woman who presented to the hospital with persistent red to brown and pink patches on both cheeks accompanied by a burning sensation for one month. Histopathological examination of a cutaneous biopsy revealed granulomatous inflammation in focal areas. Both acid-fast and Periodic acid-Schiff staining were negative. The patient was diagnosed with GR based on her clinical presentation and laboratory test results. She was treated with abrocitinib, a JAK-1 inhibitor, for 20 weeks. This resulted in substantial improvement in her rash and the associated burning sensation. Subsequent follow-up visits indicated no adverse effects or relapses. Additionally, a literature review was conducted to compare with the current case, which concluded that abrocitinib is a viable treatment option for GR, exhibiting a relatively high safety profile with minimal side effects.Keywords: JAK inhibitor, granulomatous rosacea, abrocitinib, efficacy
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- 2023
48. Triglyceride Glucose Index is Strongly Associated with a Fragility Fracture in Postmenopausal Elderly Females with Type 2 Diabetes Mellitus Combined with Osteoporosis: A 6-Year Follow-Up Study
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Pan J, Huang X, Wang Q, Sun J, Zhai Z, Mo J, Huang J, and Lu W
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type 2 diabetes mellitus ,osteoporosis ,triglyceride glucose index ,fragility fracture ,Geriatrics ,RC952-954.6 - Abstract
Jiangmei Pan,1,2,* Xiuxian Huang,1,* Qiu Wang,1,* Jingxia Sun,1,* Zhenwei Zhai,1,* Jiacheng Mo,3 Jianhao Huang,1 Wensheng Lu1 1Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China; 2Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People’s Republic of China; 3Information Network Center of Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wensheng Lu, Email Lwswxqz@163.comPurpose: The triglyceride glucose (TyG) index serves as an indicator of insulin resistance (IR), which is also associated with bone metabolism. However, research on the relationship between the TyG index and a fragility fracture in individuals with type 2 diabetes mellitus (T2DM) or osteoporosis (OP) remains sparse. This study aims to explore the association between the TyG index and fragility fracture risk in postmenopausal elderly females with T2DM combined with OP based on an ambispective cohort study.Patients and Methods: A total of 220 postmenopausal women hospitalized with T2DM combined with OP between January 2015 and December 2020 were eligible for inclusion in this study. All participants were followed up every 6 months for 6 years with a median of 42 months. According to the tertiles of the TyG index, participants were divided into three groups: low-level (≤ 8.79, n =73), moderate-level (8.80– 9.32, n=73), and high-level (≥ 9.33, n=74). The association between the TyG index and fragility fracture risk was then assessed.Results: Out of 220 patients, 46 experienced fragility fracture events (20.9%). Multivariate Cox regression analysis showed that the TyG index was positively associated with a fragility fracture in postmenopausal women with T2DM combined with OP. Furthermore, compared to the low-level group, with the TyG index level increase by 1.0, the risk for fragility fracture increased 1.293-fold in the high-level group (HR=2.293, 95% CI=1.007– 5.221, P < 0.05). Kaplan-Meier survival analysis indicated that fragility fractures were more likely to occur in patients with high levels of TyG index (log-rank, all P < 0.05).Conclusion: Our study showed that the TyG index was strongly associated with a fragility fracture in postmenopausal women with T2DM combined with OP. Therefore, special attention should be paid to postmenopausal elderly females with T2DM combined with OP in routine clinical practice.Keywords: type 2 diabetes mellitus, osteoporosis, triglyceride glucose index, fragility fracture
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- 2023
49. Performance of a cryo-cooled crystal monochromator illuminated by hard X-rays with MHz repetition rate at the European X-ray Free-Electron Laser
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Petrov, I., Boesenberg, U., Bushuev, V. A., Hallmann, J., Kazarian, K., Lu, W., Möller, J., Reiser, M., Rodriguez-Fernandez, A., Samoylova, L., Scholz, M., Sinn, H., Zozulya, A., and Madsen, A.
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Physics - Instrumentation and Detectors - Abstract
We present experimental data illustrating how heat load affects the performance of a cryogenically cooled monochromator under intense X-ray Free-Electron Laser pulses. The measurements are in good agreement with a depth-uniform model of X-ray dynamical diffraction taking beam absorption and heat deformation of the crystals into account., Comment: 9 pages, 4 figures, to be published in Optics Express
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- 2021
- Full Text
- View/download PDF
50. Probabilistic Approach for Road-Users Detection
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Melotti, G., Lu, W., Conde, P., Zhao, D., Asvadi, A., Gonçalves, N., and Premebida, C.
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,I.2.6 ,I.4.9 ,I.5.4 - Abstract
Object detection in autonomous driving applications implies that the detection and tracking of semantic objects are commonly native to urban driving environments, as pedestrians and vehicles. One of the major challenges in state-of-the-art deep-learning based object detection are false positives which occur with overconfident scores. This is highly undesirable in autonomous driving and other critical robotic-perception domains because of safety concerns. This paper proposes an approach to alleviate the problem of overconfident predictions by introducing a novel probabilistic layer to deep object detection networks in testing. The suggested approach avoids the traditional Sigmoid or Softmax prediction layer which often produces overconfident predictions. It is demonstrated that the proposed technique reduces overconfidence in the false positives without degrading the performance on the true positives. The approach is validated on the 2D-KITTI objection detection through the YOLOV4 and SECOND (Lidar-based detector). The proposed approach enables interpretable probabilistic predictions without the requirement of re-training the network and therefore is very practical., Comment: This work has been accepted for publication as a REGULAR PAPER in the Transactions on Intelligent Transportation Systems-ITS
- Published
- 2021
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