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630 results on '"Lu, Zhibing"'

11. Efficacy and safety of sympathetic mapping and ablation of renal nerves for the treatment of hypertension (SMART): 6-month follow-up of a randomised, controlled trial

Author

Wang, Jie, Yin, Yuehui, Lu, Chengzhi, Lu, Zhibing, Hu, Jialu, Wang, Yue, Ge, Junbo, Jiang, Hong, Yao, Chen, Yan, Xiaoyan, Ma, Wei, Qi, Xiaoyong, Dang, Yi, Chen, Shaoliang, Zhu, Jiancheng, Wang, Dongmei, Ding, Chao, Wang, Weimin, Liu, Jian, Wang, Yanbin, Li, Hui, Pan, Zhenhua, Cui, Kaijun, Li, Chengzong, Liang, Xinjian, Chen, Weijie, Sobotka, Paul A., Zhang, JingJing, Esler, Murray, Sun, Ningling, Chen, Minglong, and Huo, Yong

Published
2024
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21. Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes

Author

Cheng, Xu, Liu, Ye-Mao, Li, Haomiao, Zhang, Xin, Lei, Fang, Qin, Juan-Juan, Chen, Ze, Deng, Ke-Qiong, Lin, Lijin, Chen, Ming-Ming, Song, Xiaohui, Xia, Meng, Huang, Xuewei, Liu, Weifang, Cai, Jingjing, Zhang, Xiao-Jing, Zhou, Feng, Zhang, Peng, Wang, Yibin, Ma, Xinliang, Xu, Qingbo, Yang, Juan, Ye, Ping, Mao, Weiming, Huang, Xiaodong, Xia, Jiahong, Zhang, Bing-Hong, Guo, Jiao, Zhu, Lihua, Lu, Zhibing, Yuan, Yufeng, Wei, Xiang, She, Zhi-Gang, Ji, Yan-Xiao, and Li, Hongliang

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Metabolic and endocrine, Good Health and Well Being, Acidosis, Acidosis, Lactic, Aged, COVID-19, China, Coronavirus Infections, Diabetes Mellitus, Type 2, Female, Hospitalization, Humans, Kidney, Male, Metformin, Middle Aged, Pandemics, Pneumonia, Viral, Retrospective Studies, acidosis, coronavirus disease 2019, inflammation, metformin, mortality, treatment, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.

Published
2020

27. Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

Author

Zhang, Xiao-Jing, Liu, Xiaolan, Hu, Manli, Zhao, Guo-Jun, Sun, Dating, Cheng, Xu, Xiang, Hui, Huang, Yong-Ping, Tian, Rui-Feng, Shen, Li-Jun, Ma, Jun-Peng, Wang, Hai-Ping, Tian, Song, Gan, Shanyu, Xu, Haibo, Liao, Rufang, Zou, Toujun, Ji, Yan-Xiao, Zhang, Peng, Cai, Jingjing, Wang, Zhao V., Meng, Guannan, Xu, Qingbo, Wang, Yibin, Ma, Xin-Liang, Liu, Peter P., Huang, Zan, Zhu, Lihua, She, Zhi-Gang, Zhang, Xin, Bai, Lan, Yang, Hailong, Lu, Zhibing, and Li, Hongliang

Published
2021
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30. Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6

Author

Yu, Chen, primary, Zhu, Qingmei, additional, Ma, Caijiao, additional, Luo, Chuanjin, additional, Nie, Longyu, additional, Cai, Huanhuan, additional, Wang, Qiming, additional, Wang, Fubing, additional, Ren, Hong, additional, Yan, Huan, additional, Xu, Ke, additional, Zhou, Li, additional, Zhang, Caiyan, additional, Lu, Guoping, additional, Lu, Zhibing, additional, Zhu, Ying, additional, and Liu, Shi, additional

Published
2024
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44. Observation of geometric phase effect through backward angular oscillations in the H + HD → H2 + D reaction.

Author

Li, Shihao, Huang, Jiayu, Lu, Zhibing, Shu, Yiyang, Chen, Wentao, Yuan, Daofu, Wang, Tao, Fu, Bina, Zhang, Zhaojun, Wang, Xingan, Zhang, Dong H., and Yang, Xueming

Subjects
GEOMETRIC quantum phases, QUANTUM theory, QUANTUM interference, EXCHANGE reactions, OSCILLATIONS
Abstract

Quantum interference between reaction pathways around a conical intersection (CI) is an ultrasensitive probe of detailed chemical reaction dynamics. Yet, for the hydrogen exchange reaction, the difference between contributions of the two reaction pathways increases substantially as the energy decreases, making the experimental observation of interference features at low energy exceedingly challenging. We report in this paper a combined experimental and theoretical study on the H + HD → H2 + D reaction at the collision energy of 1.72 eV. Although the roaming insertion pathway constitutes only a small fraction (0.088%) of the overall contribution, angular oscillatory patterns arising from the interference of reaction pathways were clearly observed in the backward scattering direction, providing direct evidence of the geometric phase effect at an energy of 0.81 eV below the CI. Furthermore, theoretical analysis reveals that the backward interference patterns are mainly contributed by two distinct groups of partial waves (J ~ 10 and J ~ 19). The well-separated partial waves and the geometric phase collectively influence the quantum reaction dynamics. In a combined experimental and theoretical study of the H + HD → H2 + D reaction at low collision energy (1.72 eV), the authors obtain detailed information on the quantum reaction dynamics surrounding a conical intersection. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Inhibition of P21-activated Kinase 1 Promotes Vascular Smooth Muscle Cells Apoptosis Through Reduction of Phosphorylation of Bad.

Author

Jiao, Lin, Yi, Wenjuan, Chang, Yu-Rong, Cheng, Wen-Lin, Cao, Jian-Lei, Chao, Sheng-Ping, Zhao, Fang, and Lu, Zhibing

Subjects
VASCULAR smooth muscle, MUSCLE cells, GENE expression, CAROTID artery, PHOSPHORYLATION
Abstract

Background P21-activated kinase 1 (Pak1) has an effect on cell apoptosis and has recently been reported to play an important role in various cardiovascular diseases, in which vascular smooth muscle cell (VSMC) apoptosis is a key process. Thus, we hypothesized that Pak1 may be a novel target to regulate VSMC behaviors. Methods and Results In the present study, we found that the expression of Pak1 was dramatically upregulated in vascular smooth muscle cells (VSMCs) on H2O2 administration and was dependent on stimulation time. Through a loss-of-function approach, Pak1 knockdown increased apoptosis of VSMCs, as tested by TUNEL (TdT-mediated dUTP Nick-End Labeling) immunofluorescence staining, whereas it inhibited the proliferation of VSMCs examined by EdU staining. Moreover, we also noticed that Pak1 silencing promoted the mRNA and protein levels of pro-apoptosis genes but decreased anti-apoptosis marker expression. Importantly, we showed that Pak1 knockdown reduced the phosphorylation of Bad. Moreover, increased Pak1 expression was also noticed in carotid arteries on the wire jury. Conclusions Our study identified that Pak1 acted as a novel regulator of apoptosis of VSMCs partially through phosphorylation of Bad. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Lipoprotein(a) distribution and its association with carotid arteriopathy in the Chinese population

Author

Lin, Lijin, primary, Deng, Ke-Qiong, additional, Chen, Ze, additional, Lei, Fang, additional, Qin, Juan-Juan, additional, Huang, Xuewei, additional, Sun, Tao, additional, Zhang, Xingyuan, additional, Hu, Yingying, additional, Zhang, Peng, additional, Ji, Yan-Xiao, additional, Zhang, Xiao-Jing, additional, She, Zhi-Gang, additional, Lu, Zhibing, additional, Cai, Jingjing, additional, and Li, Hongliang, additional

Published
2023
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