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15. Research Progress on Sulforaphane in the Prevention and Treatment of Nervous System Diseases

Author

SONG Xiaoye, PANG Xinyi, LU Yingjian

Subjects
sulforaphane, neuroprotection, alzheimer’s disease, autism spectrum disorder, stroke, Food processing and manufacture, TP368-456
Abstract

Sulforaphane is a natural product with excellent antioxidant and anti-inflammatory effects, which is ubiquitous in plants of the Brassicaceae family. The pathogenesis of nervous system diseases is complex, but many nervous system diseases are related to inflammation and oxidative stress. Sulforaphane has great potential in the prevention and treatment of nervous system diseases. In this article, the sources, biosynthetic pathways, metabolism and mechankism of neuroprotective effect of sulforaphane is reviewed. The recent achievements in the application of sulforaphane in the prevention and treatment of neurological diseases including Alzheimer’s disease, autism spectrum disorder and stroke are summarized. Moreover, the limitations of current studies are discussed and future research directions are proposed.

Published
2023
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31. Lacticaseibacillus rhamnosusFmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition

Author

Zhao, Hongyuan, Chen, Xiaoyu, Zhang, Li, Meng, Fanqiang, Zhou, Libang, Lu, Zhaoxin, and Lu, Yingjian

Abstract

Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis, but the adverse effects of hyperuricemia on the liver have been seriously neglected. This research investigated the ameliorating effect of Lacticaseibacillus rhamnosusFmb14 on hyperuricemia induced liver dysfunction both in vitroand in vivo. Cell free extracts of high dose L. rhamnosusFmb14 treatment reduced the death rate of HepG2 cell lines from 24.1 % to 14.9 % by inhibiting NLRP3 recruitment, which was mainly activated by reactive oxygen species release and mitochondrial membrane potential disorder. In purine dietary induced hyperuricemia (PDIH) mice model, liver oedema and pyroptosis were ameliorated after L. rhamnosusFmb14 administration through downregulating the expression levels of NLRP3, caspase-1 and gasdermin-D from 1.61 to 0.86, 3.15 to 1.01 and 5.63 to 2.02, respectively. L. rhamnosusFmb14 administration restored mitochondrial inner membrane protein (MPV17) and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice, indicating that dysbiosis of mitochondrial membrane potential was restored in liver. Intriguingly, PDIH pyroptosis stimulates the process of apoptosis, which leads to severe leakage of hepatocytes, and both of pyroptosis and apoptosis were decreased after L. rhamnosusFmb14 treatment. Therefore, L. rhamnosusFmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.

Published
2024
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32. Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms.

Author

Hu, Xin, Du, Xueying, Li, Mingwei, Sun, Jing, Li, Xiangfei, Pang, Xinyi, and Lu, Yingjian

Subjects
LISTERIA monocytogenes, CHITOSAN, BIOFILMS, IONIC conductivity, NANOPARTICLES, TRANSMISSION electron microscopy, ZETA potential
Abstract

Listeria monocytogenes biofilms represent a continuous source of contamination, leading to serious food safety concerns and economic losses. This study aims to develop novel nisin‐loaded chitosan nanoparticles (CSNPs) functionalized with DNase I and evaluate its antibiofilm activity against L. monocytogenes on food contact surfaces. Nisin‐loaded CSNPs (CS‐N) were first prepared by ionic cross‐linking, and DNase I was covalently grafted on the surface (DNase‐CS‐N). The NPs were subsequently characterized by Zetasizer Nano, transmission electron microscopy, Fourier transform infrared (FT‐IR), and X‐ray diffraction (XRD). The antibiofilm activity of NPs was evaluated against L. monocytogenes on polyurethane (PU). The DNase‐CS‐N was fabricated and characterized with quality attributes (particle size—427.0 ± 15.1 nm, polydispersity [PDI]—0.114 ± 0.034, zeta potential—+52.5 ± 0.2 mV, encapsulation efficiency—46.5% ± 3.6%, DNase conjugate rate—70.4% ± 0.2). FT‐IR and XRD verified the loading of nisin and binding of DNase I with chitosan. The DNase‐CS‐N caused a 3 log colony‐forming unit (CFU)/cm2 reduction of L. monocytogenes biofilm cells, significantly higher than those in CSNPs (1.4 log), CS‐N (1.8 log), and CS‐N in combination with DNase I (2.2 log) treatment groups. In conclusion, nisin‐loaded CSNPs functionalized with DNase I were successfully prepared and characterized with smooth surface and nearly spherical shape, high surface positive charge, and good stability, which is effective to eradicate L. monocytogenes biofilm cells on food contact surfaces, exhibiting great potential as antibiofilm agents in food industry. Practical Application: Listeria monocytogenes biofilms are a common safety hazard in food processing. In this study, novel nanoparticles were successfully constructed and are expected to be a promising antibiofilm agent in the food industry. [ABSTRACT FROM AUTHOR]

Published
2024
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