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BackgroundThe last decade has witnessed many achievements in China’s health care industry, but the industry still faces major challenges among which the uneven distribution of medical resources and the imbalance between supply and demand are the most pressing problems. Although mobile health (mHealth) services play a significant role in mitigating problems associated with health care delivery, their adoption rates have been low. ObjectiveThe objective of this study was to explore the impact of resource scarcity and resource accessibility on the adoption of mHealth from the perspective of resource competition, to examine the concerning factors, and to provide a theoretical basis for promoting mHealth in China. MethodsWe used 229,516 original registration records of outpatients to conduct an empirical analysis to examine the adoption of mHealth services from the perspective of resource competition. ResultsThe adoption rate of mobile services for outpatients was low, accounting for only 31.5% (N=71,707). The empirical results indicated that resource scarcity (beta=.435, P=.01) and accessibility (beta=−.134, P=.02) have a significant impact on the adoption of mHealth. In addition, gender (beta=.073, P=.01) and age (beta=−.009, P

Website localization plays an important role in guiding firms on how to customize websites across countries in which they have a local presence. However, few studies on website localization have systematically examined this topic from a theoretically grounded perspective. Drawing upon the theoretically driven consumer-company identification perspective, we propose that three website localization strategies (web similarity strategy, web distinctiveness strategy, and web prestige strategy) have positive effects on local users' perceived website localization, which, in turn, is related to local users' website loyalty. We further investigate the effects of these website localization strategies in a cross- cultural setting, focusing on the individualism-collectivism dimension of culture. Based on our online experiments in both the United States and China, we find that these website localization strategies have significant impacts on consumers' perceived website localization, which is related to consumers' website loyalty. We also find that web distinctiveness and web prestige strategies are more effective for people from collectivistic societies than for those from individualistic societies, whereas web similarity strategies do not differ across societal types. These findings highlight the importance of website localization strategies for customizing websites for global e-commerce. [ABSTRACT FROM AUTHOR]

Decoupling economic growth and carbon emissions is essential for sustainable growth. However, the impact of ICT agglomeration, especially its long-term impact on decoupling, has received little attention. Drawing on the Tapio decoupling model and dynamic decoupling path theory, this study examines the short-term and long-term effects of ICT agglomeration on decoupling by using a panel data set for 257 cities in China from 2003 to 2017. The results show that most cities are in a state of weak decoupling (253/257) and on an intensive dynamic decoupling path (192/257). Our empirical analyses confirm that ICT agglomeration negatively impacts the short-term decoupling trend but positively impacts the long-term decoupling path. The mediating mechanism analysis indicates that ICT agglomeration affects decoupling by driving ICT infrastructure investment, promoting green technology innovation, and stimulating consumption of ICT equipment. Green technology innovation significantly drives decoupling in both the short-term and long-term impacts. [ABSTRACT FROM AUTHOR]

BACKGROUND: Insect RDL (resistant to dieldrin) receptors are essential pentameric ligand‐gated chloride channels that mediate the neuroinhibitory effect of GABA, the chief inhibitory neurotransmitter in the central nervous system. These receptors serve as primary targets for various insecticides, including noncompetitive antagonists (NCAs) such as cyclodiene organochlorines and phenylpyrazoles, as well as allosteric modulators like meta‐diamides and isoxazolines. This study focuses on a newly discovered A2′N mutation within the RDL receptors, identified in fipronil‐resistant planthoppers. Despite in vitro electrophysiological studies have proposed its role in conferring target‐site resistance, in vivo genetic functional validation of this mutation remains unexplored. RESULTS: Our research employed toxicity bioassays, assessing various Rdl genotypes against a spectrum of insecticides, including fipronil, α‐endosulfan, broflanilide, and isocycloseram. Results revealed distinct resistance profiles for A2′N and A2′S mutants, indicating different binding interactions of RDL receptors with NCAs. Significantly, the A2′N heterozygote showed substantial resistance to fipronil, despite its homozygous lethality. Molecular modeling and docking simulations further supported these findings, highlighting unique binding poses for fipronil and α‐endosulfan. CONCLUSION: This study confirmed that A2′N mutation of the RDL GABA receptor confer high resistance to fipronil in vivo. The observed resistance in A2′N mutants is likely attributable to a steric hindrance mechanism, wherein the introduction of larger side chains hampers fipronil binding, even in a heterozygous state. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]