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4. The impact of the COVID-19 pandemic on RSV outbreaks in children: A multicenter study from China

Author

Zhou, Teng, Chen, Dapeng, Chen, Qiang, Jin, Xiuhong, Su, Min, Zhang, Hong, Tian, Liyuan, Wen, Shunhang, Zhong, Lili, Ma, Yu, Ma, Dongli, Liang, Lu, Lu, Xiaoxia, Ni, Qian, Yang, Nan, Pi, Guanghuan, Zhu, Yulin, Chen, Xing, Ma, Jinhai, Jiang, Min, Wang, Jichun, Luo, Xupeng, Li, Lan, Zhang, Xiaoning, Ma, Zhan, Zhang, Man, Zhang, Hailin, Lin, Li, Xiao, Niguang, Jiang, Wujun, Gu, Wenjing, Cai, Defeng, Chen, Hongyu, Chen, Li, Lei, Jia, Du, Hui, Li, Ying, Shao, Lili, Shang, Yunxiao, Xie, Na, Lei, Xunming, Ding, Shenggang, Liang, Yan, Dong, Linghua, Chen, Xiaoyuan, Li, Yan, Zhang, Xiaobo, He, Baoping, Ren, Luo, and Liu, Enmei

Published
2024
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14. Guidelines for the prevention and management of children and adolescents with COVID-19

Author

Liu, Enmei, Smyth, Rosalind Louise, Li, Qinyuan, Qaseem, Amir, Florez, Ivan D., Mathew, Joseph L., Amer, Yasser Sami, Estill, Janne, Lu, Quan, Fu, Zhou, Lu, Xiaoxia, Chan, Edwin Shih-Yen, Schwarze, Jürgen, Wong, Gary Wing-Kin, Fukuoka, Toshio, Ahn, Hyeong Sik, Lee, Myeong Soo, Nurdiati, Detty, Cao, Bin, Tu, Wenwei, Qian, Yuan, Zhao, Shunying, Dong, Xiaoyan, Luo, Xiaoping, Chen, Zhimin, Li, Guobao, Zhang, Xiaobo, Zhao, Xiaodong, Xu, Hongmei, Xu, Feng, Shi, Yuan, Zhao, Ruiqiu, Zhao, Yao, Lei, Junqiang, Zheng, Xianlan, Wang, Mengshu, Yang, Shu, Feng, Xixi, Wu, Liqun, He, Zhihui, Liu, Shihui, Wang, Qi, Song, Yang, Luo, Zhengxiu, Zhou, Qi, Guyatt, Gordon, Chen, Yaolong, and Li, Qiu

Published
2022
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17. Effect of α-methyl on the performance of photocurable 3D printing polyurethane materials.

Author

Fei, Jianhua, Du, Xia, Rong, Youjie, Zhu, Lisheng, Zhang, Xiaomin, Li, Huijie, Lu, Xiaoxia, and Huang, Xiaobo

Subjects
THREE-dimensional printing, SOLVENTS, DYNAMIC mechanical analysis, IMPACT (Mechanics), CHEMICAL kinetics, CHEMICAL structure
Abstract

For photosensitive polyurethane systems, reactive diluents are indispensable components whose main role is to reduce the viscosity of the polyurethane prepolymer to meet the requirements of the photocurable 3D printing technology for high fluidity of the precursor solution. Generally, the reactive diluent would be involved in the photocuring reaction, which in turn has a remarkable impact on the mechanical, reaction kinetics, and thermodynamic characteristics of the photosensitive polyurethane system. However, this feature is usually neglected in the study of photosensitive urethane acrylate (PUA) systems, so there is a considerable necessity to investigate the mechanism of active diluents in the photocured reaction of PUA systems. In this work, the effects of α-methyl groups along the chains of diluent molecules on the photoreaction kinetics, photocurable 3D printing, mechanical and mechanical properties, and thermodynamic characteristics of PUAs were investigated employing hydroxyethyl methacrylate and hydroxyethyl acrylate as active diluents, respectively. The relationship between chemical structure and kinetics of PUA systems was also elucidated by using dynamic mechanical analysis tests. The results demonstrated that the α-methyl group blocks the migration of reactive radicals, reduces the efficiency of the photoreaction, and causes an increase in the rigidity and strength of the molecular chain. This study not only revealed the effect of α-methyl on the kinetic mechanical and thermal performance of PUA systems but also paves the way for the development of a new class of photosensitive PUA materials used for the photocurable 3D printing technology. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Corrigendum to “Prevalence of respiratory viruses among hospitalized children with lower respiratory tract infections during the COVID-19 pandemic in Wuhan, China” [International Journal of Infectious Diseases 139 (2024) pages 6-12]

Author

Li, Ying, primary, Wu, Zhiyong, additional, Yan, Yi, additional, Shi, Yue, additional, Huang, Jiaming, additional, Du, Hui, additional, Du, Qing, additional, Li, Yang, additional, Lin, Yaxin, additional, Liu, Di, additional, and Lu, Xiaoxia, additional

Published
2024
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22. Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently

Author

Zhou, Qi, Li, Qinyuan, Estill, Janne, Wang, Qi, Wang, Zijun, Shi, Qianling, Zhang, Jingyi, Zhang, Xiaobo, Mathew, Joseph L., Smyth, Rosalind L., Nurdiati, Detty, Fu, Zhou, Xu, Hongmei, Zheng, Xianlan, Zhao, Xiaodong, Lu, Quan, Liu, Hui, Xun, Yangqin, Li, Weiguo, Yang, Shu, Feng, Xixi, Wang, Mengshu, Lei, Junqiang, Luo, Xiaoping, Wu, Liqun, Lu, Xiaoxia, Lee, Myeong Soo, Zhao, Shunying, Chan, Edwin Shih-Yen, Qian, Yuan, Tu, Wenwei, Dong, Xiaoyan, Li, Guobao, Zhao, Ruiqiu, He, Zhihui, Zhao, Siya, Liu, Xiao, Li, Qiu, Yang, Kehu, Luo, Zhengxiu, Liu, Enmei, and Chen, Yaolong

Published
2022
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27. Microplastics in ports worldwide: Environmental concerns or overestimated pollution levels?

Author

Supe Tulcan, Roberto Xavier and Lu, Xiaoxia

Abstract

Plastic pollution, a pervasive environmental crisis, arises from the improper disposal of non-biodegradable plastics, endangering species and ecosystems worldwide. While microplastics (MPs) have been extensively studied in various ecosystems, they have received scant attention in port environments, despite their pervasive presence. This review selected published articles conducted in ports worldwide between 2010 and 2024 to determine the concentration, accumulation characteristics, and driving factors. A total of 57 studies across 78 ports met the selection criteria, examining water, sediment, and biota in 49, 51, and 23 ports, respectively. The average concentrations of MPs in water collected by net and grab sampling, sediment, fish, and invertebrates were approximately 39.2 ± 68.4 items/m3, 4100.7 ± 5761.8 items/m3, 243.6 ± 240.2 items/kg, 26.1 ± 21.1 items/individual, and 9.4 ± 8.1 items/individual in ports worldwide, respectively. Asia and the Americas exhibited the highest concentration of MPs in ports across all media. The dominant MP morphotypes included fibers, fragments, films, foams, pellets, and spheres, with sizes frequently between 1 and 1000 μm in biota and water and between 1 and 5 mm in sediments. Port structures and the presence of rivers are key drivers of MP accumulation. MP pollution in ports poses potential ecological and health risks. Among the studied ports, 23% had MP numbers in sediment greater than the predicted no effect concentration (PNEC). The presence of MP in biota and the capability of MP to adsorb other contaminants pose a threat to human health. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Self-Assessed Educational Needs of Chinese Pediatric Clinicians Regarding Pediatric Palliative Care: A Cross-Sectional Investigation.

Author

Lu, Xiaoxia, Wang, Yanmei, Li, Jingke, Chang, Yue-Cune, and Peng, Niang-Huei

Subjects
SELF-evaluation, PEDIATRIC nurses, WORK, CROSS-sectional method, PATIENTS' families, PALLIATIVE treatment, PEDIATRICIANS, MEDICAL personnel, NEONATAL intensive care units, QUESTIONNAIRES, STATISTICAL sampling, FISHER exact test, PHYSICIANS' attitudes, CHILDREN'S hospitals, NEONATAL intensive care, DESCRIPTIVE statistics, CHI-squared test, MANN Whitney U Test, PATIENT care, INFORMATION needs, PEDIATRICS, NURSES' attitudes, INTENSIVE care units, CLINICAL competence, PAIN management, COMMUNICATION, GRIEF therapy, PATIENT-professional relations, DATA analysis software, FAMILY support, PSYCHOSOCIAL factors, EXPERIENTIAL learning
Abstract

Background: An important first step in enhancing professional palliative care training is to investigate the educational needs of pediatric clinicians in this field. The aims of this research were to analyze the extent of end-of-life care experience of Chinese pediatric clinicians and identify the differing educational needs of physicians and nurses as well as associated impact factors. Methods: A cross-sectional descriptive survey via a structural questionnaire was used in this research. Results: In total, 187 clinicians, comprising 52 physicians and 135 nurses, participated in this study. The topics "pain management", "symptom management", and "discussing the prognosis with family members" were the most expressed educational needs among both physicians and nurses. Compared to nurses, physicians placed greater emphasis on the importance of "communication" and "pain and symptom management" (p < 0.05). Clinicians with more extensive end-of-life care experience more strongly felt the importance of learning about pain management and communication regarding end-of-life care (p < 0.05). Conclusions: Research showed that the education currently provided to pediatric clinicians does not meet their distinctive needs. Future palliative care education must be a continuing multi-level, interdisciplinary program and different education should be provided to physicians and nurses based on their respective needs. [ABSTRACT FROM AUTHOR]

Published
2024
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30. An Improved Method of Cache Prefetching for Small Files in Ceph System

Author

Fan, Ya, Wang, Yong, Ye, Miao, Lu, Xiaoxia, Huan, YiMing, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Krömer, Pavel, editor, Zhang, Hong, editor, Liang, Yongquan, editor, and Pan, Jeng-Shyang, editor

Published
2019
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46. Simple and Ultrasensitive Detection of Glioma-Related ctDNAs in Mice Serum by SERS-Based Catalytic Hairpin Assembly Signal Amplification Coupled with Magnetic Aggregation

Author

Wang,Youwei, Yang,Yang, Cao,Xiaowei, Liu,Zhensheng, Chen,Bing, Du,Qiu, and Lu,Xiaoxia

Subjects
International Journal of Nanomedicine
Abstract

Youwei Wang,1,&ast; Yang Yang,2,&ast; Xiaowei Cao,3 Zhensheng Liu,4 Bing Chen,5 Qiu Du,1,&ast; Xiaoxia Lu6,&ast; 1Department of Neurosurgery, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China; 2Department of Clinical Laboratory, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China; 3Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China; 4Department of Interventional Radiology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China; 5Department of neurosurgery, The Affiliated hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China; 6Department of Oncology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaoxia Lu, Department of oncology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China, Tel +86 514-82981199, Email luxiaoxia19870318@126.com Qiu Du, Department of neurosurgery, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China, Tel +86 514-82981199, Email 092102@yzu.edu.cnPurpose: Circulating tumor DNA (ctDNA) is more representative and accurate than biopsy and is also conducive to dynamic monitoring, facilitating accurate diagnosis and prognosis of glioma. Therefore, the present study aimed to establish and validate a novel amplified method for the detection of IDH1 R132H and BRAF V600E, which were associated with the genetic diagnosis of glioma.Patients and Methods: A dual-signal amplification method based on magnetic aggregation and catalytic hairpin assembly (CHA) was constructed for the simultaneous detection of ctDNAs. When target ctDNAs are present, the CHA reaction is initiated and leads to the assembly of Au-Ag nanoshuttles (Au-Ag NSs) onto magnetic beads (MBs). Further enrichment of MBs under an external magnetic field facilitated the dual-signal amplification of SERS.Results: The limit of detection (LOD) for IDH1 R132H and BRAF V600E in serum was as low as 6.01 aM and 5.48 aM. The reproducibility and selectivity of the proposed SERS analysis platform was satisfactory. Finally, the platform was applied to quantify IDH1 R132H and BRAF V600E in the serum of subcutaneous-tumor‑bearing nude mice, and the results obtained by SERS were consistent with those from quantitative real-time polymerase chain reaction (qRT-PCR).Conclusion: The present study showed that the dual-signal amplification method is a simple and ultrasensitive strategy for gliomas-associated ctDNAs detection, which is crucial for early diagnosis and dynamic monitoring.Keywords: circulating tumor DNA, Au-Ag nanoshuttles, magnetic beads, catalytic hairpin assembly, surface-enhanced Raman spectroscopy

Published
2023

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