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4,384 results on '"Lu, Xiang"'

1. DeepMachining: Online Prediction of Machining Errors of Lathe Machines

Author

Lu, Xiang-Li, Hsu, Hwai-Jung, Chou, Che-Wei, Kung, H. T., Lee, Chen-Hsin, and Cheng, Sheng-Mao

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

We describe DeepMachining, a deep learning-based AI system for online prediction of machining errors of lathe machine operations. We have built and evaluated DeepMachining based on manufacturing data from factories. Specifically, we first pretrain a deep learning model for a given lathe machine's operations to learn the salient features of machining states. Then, we fine-tune the pretrained model to adapt to specific machining tasks. We demonstrate that DeepMachining achieves high prediction accuracy for multiple tasks that involve different workpieces and cutting tools. To the best of our knowledge, this work is one of the first factory experiments using pre-trained deep-learning models to predict machining errors of lathe machines.

Published
2024

2. ZSL-RPPO: Zero-Shot Learning for Quadrupedal Locomotion in Challenging Terrains using Recurrent Proximal Policy Optimization

Author

Zhao, Yao, Wu, Tao, Zhu, Yijie, Lu, Xiang, Wang, Jun, Bou-Ammar, Haitham, Zhang, Xinyu, and Du, Peng

Subjects
Computer Science - Robotics
Abstract

We present ZSL-RPPO, an improved zero-shot learning architecture that overcomes the limitations of teacher-student neural networks and enables generating robust, reliable, and versatile locomotion for quadrupedal robots in challenging terrains. We propose a new algorithm RPPO (Recurrent Proximal Policy Optimization) that directly trains recurrent neural network in partially observable environments and results in more robust training using domain randomization. Our locomotion controller supports extensive perturbation across simulation-to-reality transfer for both intrinsic and extrinsic physical parameters without further fine-tuning. This can avoid the significant decline of student's performance during simulation-to-reality transfer and therefore enhance the robustness and generalization of the locomotion controller. We deployed our controller on the Unitree A1 and Aliengo robots in real environment and exteroceptive perception is provided by either a solid-state Lidar or a depth camera. Our locomotion controller was tested in various challenging terrains like slippery surfaces, Grassy Terrain, and stairs. Our experiment results and comparison show that our approach significantly outperforms the state-of-the-art.

Published
2024

10. Efficient spectral broadening and few-cycle pulse generation with multiple thin water films

Author

Huang, Jiacheng, Lu, Xiang, Hu, Feilong, Long, Jie, Tang, Jiajun, He, Lixin, Zhang, Qingbin, Lan, Pengfei, and Lu, Peixiang

Subjects
Physics - Optics, Physics - Atomic and Molecular Clusters
Abstract

High-energy, few-cycle laser pulses are essential for numerous applications in the fields of ultrafast optics and strong-field physics, due to their ultrafast temporal resolution and high peak intensity. In this work, different from the traditional hollow-core fibers and multiple thin solid plates, we represent the first demonstration of the octave-spanning supercontinuum broadening by utilizing multiple ultrathin liquid films (MTLFs) as the nonlinear media. The continuum covers a range from 380 to 1050 nm, corresponding to a Fourier transform limit pulse width of 2.5 fs, when 35 fs Ti:sapphire laser pulse is applied on the MTLFs. The output pulses are compressed to 3.9 fs by employing chirped mirrors. Furthermore, a continuous high-order harmonic spectrum up to the 33rd order is realized by subjecting the compressed laser pulses to interact with Kr gas. The utilization of flowing water films eliminates permanent optical damage and enables wider and stronger spectrum broadening. Therefore, this MTLFs scheme provides new solutions for the generation of highly efficient femtosecond supercontinuum and nonlinear pulse compression, with potential applications in the fields of strong-field physics and attosecond science., Comment: 9 pages, 5 figures

Published
2023

16. Fine-tuning of IPA1 transactivation activity by E3 ligase IPI7-mediated non-proteolytic K29-ubiquitination during Magnaporthe oryzae infection

Author

Shi, Hui, Yin, Junjie, Zhao, Zhangjie, Yu, Hong, Yi, Hong, Xu, Li, Tong, Huimin, He, Min, Zhu, Xiaobo, Lu, Xiang, Xiong, Qing, Li, Weitao, Tang, Yongyan, Hou, Qingqing, Song, Li, Wang, Long, Chen, Xiaoqiong, Sun, Changhui, Li, Ting, Fan, Jing, Li, Yan, Qin, Peng, Wang, Wen-Ming, Li, Shigui, Chen, Xuewei, Li, Jiayang, and Wang, Jing

Published
2024
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20. Genomic insight into the origin, domestication, dispersal, diversification and human selection of Tartary buckwheat

Author

He, Yuqi, Zhang, Kaixuan, Shi, Yaliang, Lin, Hao, Huang, Xu, Lu, Xiang, Wang, Zhirong, Li, Wei, Feng, Xibo, Shi, Taoxiong, Chen, Qingfu, Wang, Junzhen, Tang, Yu, Chapman, Mark A., Germ, Mateja, Luthar, Zlata, Kreft, Ivan, Janovská, Dagmar, Meglič, Vladimir, Woo, Sun-Hee, Quinet, Muriel, Fernie, Alisdair R., Liu, Xu, and Zhou, Meiliang

Published
2024
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27. Sunflower seed and peanut peptide calcium-complex promote bone mass accumulation in growing female KM mice fed a low calcium diet by improving calcium bioavailability and bone type I collagen synthesis

Author

Xingyu Yuan, Zhe Jiang, Lu Xiang, Wenjun Feng, and Xiaolan Bao

Subjects
Sunflower seed and peanut, Peptide calcium-complex, Calcium deficiency, Bone mass accumulation, Binding toughness, Type I collage, Nutrition. Foods and food supply, TX341-641
Abstract

Previous studies have indicated that Sunflower Seed Peptide (SSP)-Ca and peanut peptide (PP)-Ca improve Ca bioavailability and enhance bone mineral density in low-Ca diet-fed male mice. However, the mechanisms of SSP-Ca and PP-Ca act in bone metabolism, and whether their effect is affected by sex remain unclear. In this study, 5 week-old female KM mice were fed a low-Ca diet and gavaged with different doses of SSP-Ca, PP-Ca, or CaCO3 for 5 weeks. SSP-Ca and PP-Ca supplementation ameliorated femur binding toughness, BMD and microarchitecture. SSP-Ca and PP-Ca intake increased the bone type I collagen levels and Co1la1 mRNA expression. SSP-Ca and PP-Ca intake also significantly increased the serum P1NP levels. In conclusion, SSP-Ca and PP-Ca promote bone mass accumulation in growing female mice fed with a low-Ca diet by improving Ca bioavailability and bone type I collagen synthesis. The study provided novel insights for Ca supplementation in adolescence.

Published
2024
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29. Simulation of Main Pump Two-Speed Start-Up Strategy of Advanced Small Reactor Based on Stable operation of Once-Through Steam Generator

Author

Ruan, Tian-ming, Chen, Tian-ming, Yan, Ya-lun, Li, Ke-jia, Cao, Jian-hua, Lu, Xiang-hui, Rui, Min, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Gu, Pengfei, editor, Xu, Yang, editor, Chen, Weihua, editor, Wang, Zhongqiu, editor, Sun, Yongbin, editor, and Liu, Zheming, editor

Published
2024
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30. Simulation of Operation Characteristics of Helical Coiled Once-Through Steam Generator in Start-Up Stage

Author

Gao, Ya-xin, Zheng, Xiong, Chen, Tian-ming, Zhou, Ming-jia, Mao, Yu-long, Hu, Yi-song, Lu, Xiang-hui, Rui, Min, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Gu, Pengfei, editor, Xu, Yang, editor, Chen, Weihua, editor, Wang, Zhongqiu, editor, Sun, Yongbin, editor, and Liu, Zheming, editor

Published
2024
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31. Simulation of Fouling Effect on OTSG Flow and Heat Transfer Performance

Author

Mao, Yulong, Jin, De-sheng, Wang, Xiao-ting, Li, Ke-jia, Meng, Shu-qi, Hu, Yi-song, Lu, Xiang-hui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Gu, Pengfei, editor, Xu, Yang, editor, Chen, Weihua, editor, Wang, Zhongqiu, editor, Sun, Yongbin, editor, and Liu, Zheming, editor

Published
2024
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32. Control Strategy Research on HOTSG Hydrodynamic Instability During ELPO Mode for Two-Loop SMR

Author

Jin, De-sheng, Li, Ke-jia, Gao, Ya-xin, Cheng, Yi, Meng, Shu-qi, Hu, Yi-song, Mao, Yu-long, Lu, Xiang-hui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Gu, Pengfei, editor, Xu, Yang, editor, Chen, Weihua, editor, Wang, Zhongqiu, editor, Sun, Yongbin, editor, and Liu, Zheming, editor

Published
2024
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35. Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance

Author

Jianfeng Cui, Xiaochen Liu, Qinghong Shang, Shuna Sun, Shouzhen Chen, Jianping Dong, Yaofeng Zhu, Lei Liu, Yangyang Xia, Yong Wang, Lu Xiang, Bowen Fan, Jiafeng Zhan, Yadi Zhou, Pengxiang Chen, Renchang Zhao, Xiaofei Liu, Nianzeng Xing, Dalei Wu, Benkang Shi, and Yongxin Zou

Subjects
CDC6, OTUD6A, Deubiquitinating enzyme, Tumorigenesis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. Methods The proteome-wide deubiquitinase (DUB) screening was used to identify the potential regulator of CDC6. Immunofluorescence, protein half-life and deubiquitination assays were performed to determine the protein stability of CDC6. Gain- and loss-of-function experiments were implemented to analyse the impacts of OUTD6A-CDC6 axis on tumour growth and chemosensitivity in vitro. N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced conditional Otud6a knockout (CKO) mouse model and tumour xenograft model were performed to analyse the role of OTUD6A-CDC6 axis in vivo. Tissue specimens were used to determine the association between OTUD6A and CDC6. Results OTUD6A interacts with, depolyubiquitinates and stabilizes CDC6 by removing K6-, K33-, and K48-linked polyubiquitination. Moreover, OTUD6A promotes cell proliferation and decreases sensitivity to chemotherapy by upregulating CDC6. CKO mice are less prone to BCa tumorigenesis induced by BBN, and knockdown of OTUD6A inhibits tumour progression in vivo. Furthermore, OTUD6A protein level has a positive correlation with CDC6 protein level, and high protein levels of OTUD6A and CDC6 are associated with poor prognosis in patients with bladder cancer. Conclusions We reveal an important yet missing piece of novel DUB governing CDC6 stability. In addition, our findings propose a model for the OTUD6A-CDC6 axis that provides novel insights into cell cycle and chemosensitivity regulation, which may become a potential biomarker and promising drug target for cancer treatment.

Published
2024
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36. Overview of Cross-Chain Identity Authentication Based on DID

Author

BAI Yirui, TIAN Ning, LEI Hong, LIU Xuefeng, LU Xiang, ZHOU Yong

Subjects
decentralized identity, blockchain, cross-chain, identity authentication, Electronic computers. Computer science, QA75.5-76.95
Abstract

With the emergence of concepts such as metaverse and Web3.0, blockchain plays a very important role in many fields. Cross-chain technology is an important technical means to achieve inter-chain interconnection and value transfer. At this stage, traditional cross-chain technologies such as notary and sidechain have trust issues. At the same time, in the field of cross-chain identity authentication, there are problems that the identities of each chain are not unified and users do not have control over their own identities. Firstly, it systematically summarizes the development process and technical solutions of digital identity and cross-chain technology, and analyzes and compares four digital identity models and nine mainstream cross-chain projects. Secondly, by analyzing the main research results of cross-chain identity authentication in recent years, a general model of cross-chain identity authentication is designed, and the shortcomings of existing solutions are summarized. Then, it focuses on the cross-chain identity authentication implementation scheme based on DID, and analyzes the technical characteristics, advantages and disadvantages of different solutions. On this basis, three DID-based cross-chain identity authentication models are summarized, the main implementation steps are functionally described, and their advantages, limitations and efficiency are analyzed. Finally, in view of the shortcomings of the current DID-based cross-chain identity authentication model, its development difficulties are discussed and five possible future research directions are given.

Published
2024
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40. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.

Author

Richman, Jeffrey, Vaca, Raymond, Plascencia, Mary, Gu, Xiaofeng, Zhang, Shasha, Tamai, T, Zhang, Liguo, Gao, Fuying, Ouk, Koliane, Lu, Xiang, Ivanov, Leonid, Vogt, Thomas, Lu, Qing, Morton, A, Stricos, Matthew, Aaronson, Jeffrey, Rosinski, Jim, Horvath, Steve, Yang, Xiangdong, Colwell, Christopher, Ramanathan, Lalini, Wang, Nan, and Langfelder, Peter

Subjects
Huntington’s disease, Parkinson’s disease, Trank1, WGCNA, bipolar disorder, coexpression, cortex, diurnal, gene, striatum, Animals, Mice, Transcriptome, Protein Kinase C-theta, Gene Regulatory Networks, Huntington Disease, Brain
Abstract

Brain tissue transcriptomes may be organized into gene coexpression networks, but their underlying biological drivers remain incompletely understood. Here, we undertook a large-scale transcriptomic study using 508 wild-type mouse striatal tissue samples dissected exclusively in the afternoons to define 38 highly reproducible gene coexpression modules. We found that 13 and 11 modules are enriched in cell-type and molecular complex markers, respectively. Importantly, 18 modules are highly enriched in daily rhythmically expressed genes that peak or trough with distinct temporal kinetics, revealing the underlying biology of striatal diurnal gene networks. Moreover, the diurnal coexpression networks are a dominant feature of daytime transcriptomes in the mouse cortex. We next employed the striatal coexpression modules to decipher the striatal transcriptomic signatures from Huntingtons disease models and heterozygous null mice for 52 genes, uncovering novel functions for Prkcq and Kdm4b in oligodendrocyte differentiation and bipolar disorder-associated Trank1 in regulating anxiety-like behaviors and nocturnal locomotion.

Published
2022

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