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It is always a hot issue in the research process of software project to focus on specific field, construct software architecture, find efficient technology of software development, and improve the efficiency and reuse of software development . On the basis of software design in the field of Industrial Control, we put forward a design method based on the flow, resource and data. The concepts of flow and resource are defined based on the construction of the software's basic architecture. Problems and process of the solutions are expressed as flow; hardware and code used in the flow are shown as resource; data in different levels may have different explanations and structures, because data image realizes the coupling of flow and heterogeneous data in the resource. Because of the dependence of software design, designers' knowledge in specific field and computer ability is reduced, the software characters of versatility and reuse are enhanced. [ABSTRACT FROM AUTHOR]

Near monodisperse Fe3O4 sub-microspheres with an average diameter of 170 nm have been synthesized by a solvothermal reduction method, using K3[Fe(CN)6] as the raw material in the absence of any surfactants at 200°C for 24 h. The products were detected by XRD, FESEM, TEM, and XPS. The investigation of the reaction parameters indicates that ethylene glycol plays a key role both as reducing agent and solvent. In addition, the reaction time and temperature also have important influences on the final product. The hysteresis loop of the near monodisperse Fe3O4 sub-microspheres shows a ferromagnetic behavior with saturation magnetization of 60.8 emu/g and coercivity of 124.7 Oe. [ABSTRACT FROM AUTHOR]

Ovarian cancer has the highest mortality rate among all gynecological cancers with its pathogenic mechanisms largely unknown. Here, we uncovered that ovarian cancer tissues exhibit higher heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) expression than normal ovarian epithelium tissues. Increased hnRNPA2B1 level matches along with poor prognosis of ovarian cancer patients. Importantly, hnRNPA2B1 inhibition hampers growth, reduces mobility of ovarian cancer cells in vitro and hinders xenograft tumor formation in vivo. Transcriptome profiling analysis reveals that hnRNPA2B1 dictates the expression of various important genes involved in tumorigenesis and Lin-28 Homolog B (Lin28B) is down-regulated upon hnRNPA2B1 loss. hnRNPA2B1 regulates expression of Lin28B via binding to Lin28B mRNA and enhancing its stability. Furthermore, knockdown of Lin28B reduces proliferation and mobility of ovarian cancer cells and impairs tumorigenesis in vivo, whereas Lin28B overexpression promotes xenograft tumor formation. Finally, re-expression of Lin28B in hnRNPA2B1 knockdown cells results in rescued phenotypes. Collectively, our results demonstrate that hnRNPA2B1 facilitates the malignant phenotype of ovarian cancer through activating Lin28B expression. [ABSTRACT FROM AUTHOR]