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4. Prognostic Significance of VAV3 Gene Variants and Expression in Renal Cell Carcinoma.

Author

Chang, Chi-Fen, Bao, Bo-Ying, Hsueh, Yu-Mei, Chen, Pei-Ling, Chang, Li-Hsin, Li, Chia-Yang, Geng, Jiun-Hung, Lu, Te-Ling, Huang, Chao-Yuan, and Huang, Shu-Pin

Subjects
GUANINE nucleotide exchange factors, CELL receptors, GENE expression, LOCUS (Genetics), GENETIC variation
Abstract

Renal cell carcinoma (RCC) is characterized by high mortality and morbidity rates. Vav guanine nucleotide exchange factors (VAVs), crucial for signal transduction between cell membrane receptors and intracellular mediators, have been implicated in carcinogenesis. However, their potential prognostic value in RCC remains unclear. The impact of 150 common VAV polymorphisms on RCC risk and survival was investigated in a cohort of 630 individuals. Publicly available gene expression datasets were utilized to analyze VAV gene expression in relation to patient outcomes. The VAV3 rs17019888 polymorphism was significantly associated with RCC risk and overall survival after adjusting for false discovery rates. Expression quantitative trait loci analysis revealed that the risk allele of rs17019888 is linked to reduced VAV3 expression. Analysis of 19 kidney cancer gene expression datasets revealed lower VAV3 expression in RCC tissues compared to normal tissues, with higher expression correlating with better prognosis. Gene set enrichment analysis demonstrated that VAV3 negatively regulates the ubiquitin–proteasome system, extracellular matrix and membrane receptors, inflammatory responses, matrix metalloproteinases, and cell cycle pathways. Furthermore, elevated VAV3 expression was associated with increased infiltration of B cells, macrophages, and neutrophils into the RCC tumor microenvironment. Our findings suggest that VAV3 gene variants influence RCC risk and survival, contributing to a favorable prognosis in RCC. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Integrated analysis identifies GABRB3 as a biomarker in prostate cancer.

Author

Chen, Jun-Yan, Chang, Chi-Fen, Huang, Shu-Pin, Huang, Chao-Yuan, Yu, Chia-Cheng, Lin, Victor C., Geng, Jiun-Hung, Li, Chia-Yang, Lu, Te-Ling, and Bao, Bo-Ying

Subjects
PROSTATE cancer, PROSTATE cancer patients, ANDROGEN deprivation therapy, PI3K/AKT pathway, GENE expression, BIOMARKERS, ANDROGEN drugs, PHOSPHOINOSITIDES
Abstract

Background: Treatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate cancer. Thus, understanding the genetic factors influencing this process could facilitate the development of personalized treatments and innovative therapeutic strategies. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in controlling cell growth and tumorigenesis. We hypothesized that genetic variants within this pathway may affect the clinical outcomes of patients undergoing ADT for prostate cancer. Methods: We genotyped 399 single-nucleotide polymorphisms (SNPs) across 28 core PI3K/AKT pathway genes in a cohort of 630 patients with prostate cancer undergoing ADT. We assessed the potential association of the SNPs with patient survival. Functional analyses of the implicated genes were also performed to evaluate their effects on prostate cancer. Results: After multivariate Cox regression analysis and multiple testing correction, GABRB3 rs12591845 exhibited the most significant association with both overall and cancer-specific survivals (P < 0.003). A comprehensive pooled analysis of 16 independent gene expression datasets revealed elevated expression of GABRB3 in prostate cancer tissues compared to that in normal tissues (P < 0.001). Furthermore, gene set enrichment analysis unveiled differential enrichment of pathways such as myogenesis, interferon γ and α responses, and the MYC proto-oncogene pathway in tumors with elevated GABRB3 expression, implying a role for GABRB3 in prostate cancer. Conclusion: Our results suggest that rs12591845 could potentially serve as a valuable prognostic indicator for patients undergoing ADT. The potential role of GABRB3 in promoting prostate tumorigenesis is also highlighted. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Data from Polymorphisms inside MicroRNAs and MicroRNA Target Sites Predict Clinical Outcomes in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy

Author

Bao, Bo-Ying, primary, Pao, Jiunn-Bey, primary, Huang, Chun-Nung, primary, Pu, Yeong-Shiau, primary, Chang, Ta-Yuan, primary, Lan, Yu-Hsuan, primary, Lu, Te-Ling, primary, Lee, Hong-Zin, primary, Juang, Shin-Hun, primary, Chen, Lu-Min, primary, Hsieh, Chi-Jeng, primary, and Huang, Shu-Pin, primary

Published
2023
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12. Supplementary Table S1 from Polymorphisms inside MicroRNAs and MicroRNA Target Sites Predict Clinical Outcomes in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy

Author

Bao, Bo-Ying, primary, Pao, Jiunn-Bey, primary, Huang, Chun-Nung, primary, Pu, Yeong-Shiau, primary, Chang, Ta-Yuan, primary, Lan, Yu-Hsuan, primary, Lu, Te-Ling, primary, Lee, Hong-Zin, primary, Juang, Shin-Hun, primary, Chen, Lu-Min, primary, Hsieh, Chi-Jeng, primary, and Huang, Shu-Pin, primary

Published
2023
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17. Additional file 1 of TNFRSF13B is a potential contributor to prostate cancer

Author

Li, Chia-Yang, Huang, Shu-Pin, Chen, Yei-Tsung, Wu, Hsin-En, Cheng, Wei-Chung, Huang, Chao-Yuan, Yu, Chia-Cheng, Lin, Victor C., Geng, Jiun-Hung, Lu, Te-Ling, and Bao, Bo-Ying

Abstract

Additional file: Supplementary Tables. Table S1. Regulatory annotation of TNFRSF13B rs4792800 and its linked variants. Table S2. List of differentially expressed genes upon TNFRSF13B knockdown that overlapped in both 22Rv1 and PC-3 human prostate cancer cells. Table S3. List of differentially expressed cell cycle- and p53 signalling pathway-related genes with opposite responses to TNFRSF13B knockdown between 22Rv1 and PC-3 cells.

Published
2022
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22. Association between the polygenic liabilities for prostate cancer and breast cancer with biochemical recurrence after radical prostatectomy for localized prostate cancer

Author

Wang, Shi-Heng, Huang, Shu-Pin, Pan, Yi-Jiun, Hsiao, Po-Chang, Li, Chia-Yang, Chen, Lih-Chyang, Yu, Chia-Cheng, Huang, Chao-Yuan, Lin, Victor C, Lu, Te-Ling, and Bao, Bo-Ying

Subjects
Original Article
Abstract

Prostate and breast cancers are hormone-related malignancies and are characterized by a complex interplay of hundreds of susceptibility loci throughout the genome. Prostate cancer could be inhibited by eliminating androgens through castration or estrogen administration, thus facilitating long-term treatment of prostate cancer; however, the role of estrogen in prostate cancer remains unclear. This study aimed to determine whether polygenic risk scores (PRSs) comprising combinations of genome-wide susceptibility variants influence the clinical outcomes of prostate cancer patients. The study subjects were recruited from four medical centers in Taiwan, and genome-wide genotyping data were obtained from 643 prostate cancer patients. We derived the PRS for prostate cancer (PRS-PC) and for breast cancer (PRS-BC) for each patient. The association between the PRS-PC/PRS-BC at the age of prostate cancer onset and recurrence within seven years was evaluated using a regression model adjusted for population stratification components. A higher PRS-PC was associated with an earlier onset age for prostate cancer (beta in per SD increase in PRS = -0.89, P = 0.0008). In contrast, a higher PRS-BC was associated with an older onset age for prostate cancer (beta = 0.59, P = 0.02). PRS-PC was not associated with the risk of recurrence (hazard ratio = 1.03, P = 0.67), whereas a higher PRS-BC was associated with a low recurrence risk (hazard ratio = 0.86, P = 0.03). These results indicate that the genetic predisposition to breast cancer is associated with a low risk of prostate cancer recurrence. Further studies are warranted to explore the role of breast cancer susceptibility variants and estrogen signaling in prostate cancer progression.

Published
2021

44. Phenylpropanoids and lignoids from the whole plant of Vaccinium emarginatum and their cytotoxicity against prostate cancer cells.

Author

Tu, Ping-Chen, Liang, Yu-Chia, Kao, Ming-Ching, Chao, Louis Kuoping, Tseng, Mei-Hwei, Lu, Te-Ling, Sung, Ping-Jyun, and Kuo, Yueh-Hsiung

Subjects
PHENYLPROPANOIDS, VACCINIUM, CANCER cells, PROSTATE cancer, PLANT extracts, DIPHENYL, ETHYL acetate
Abstract

One new naturally occurring quinone, 3′,4′-dihydroxy-1,2,6-trimethoxy-[1,1′-biphenyl]-4(1H)-one (1), one new diarylpropane, emarginone A (2), and one new neolignan, emarginone B (3), along with eighteen known compounds have been isolated from the chemical investigation of the EtOAc-soluble fraction of the Vaccinium emarginatum whole plant methanolic extract. The new structures were elucidated by combined analysis of spectroscopic analytical methods and comparison with the literature data obtained from known analogues. In addition, the cytotoxicity of compounds 2, 4, and 14–20 against Du145 and PC-3 prostate cancer cell lines using MTT cell proliferation assay was evaluated. Compounds 2 and 19 showed most potent cytotoxicity against Du145 with IC50 values of 7.53 and 6.63 μg/mL, respectively. Furthermore, compounds 2, 17, and 19 also exhibited significant cytotoxicity against PC-3 with IC50 values ranging from 3.44-6.64 μg/mL. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Prognostic Value of CD1B in Localised Prostate Cancer

Author

Lee, Cheng-Hsueh, primary, Chen, Lih-Chyang, additional, Yu, Chia-Cheng, additional, Lin, Wen-Hsin, additional, Lin, Victor C., additional, Huang, Chao-Yuan, additional, Lu, Te-Ling, additional, Huang, Shu-Pin, additional, and Bao, Bo-Ying, additional

Published
2019
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48. MST3 is involved in ENaC-mediated hypertension

Author

Lu, Te-Jung, primary, Kan, Wei-Chih, additional, Yang, Sung-Sen, additional, Jiang, Si-Tse, additional, Wu, Sheng-Nan, additional, Ling, Pin, additional, Bao, Bo-Ying, additional, Lin, Chia-Yu, additional, Yang, Zin-Ya, additional, Weng, Yui-Ping, additional, Chan, Chee-Hong, additional, and Lu, Te Ling, additional

Published
2019
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49. Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy

Author

Yu, Chia‐Cheng, primary, Chen, Lih‐Chyang, additional, Lin, Victor C., additional, Huang, Chao‐Yuan, additional, Cheng, Wei‐Chung, additional, Hsieh, Ai‐Ru, additional, Chang, Ta‐Yuan, additional, Lu, Te‐Ling, additional, Lee, Cheng‐Hsueh, additional, Huang, Shu‐Pin, additional, and Bao, Bo‐Ying, additional

Published
2019
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