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5. Contributors

Author

Agarwal, Rachit, primary, Ahlstrom, Jon D., additional, Ahmad, Rafiq, additional, Alarcon, Emilio I., additional, Almarza, Alejandro J., additional, Almeida-Porada, Graça, additional, Almeida, Manuel, additional, Alvarado-Velez, Melissa, additional, Anderson, James M., additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Balkan, Wayne, additional, Ballios, Brian G., additional, Baptista, Pedro M., additional, Baumann, M. Douglas, additional, Bedi, Supinder S., additional, Bellamkonda, Ravi V., additional, Bergmann, Nicole M., additional, Blau, Helen M., additional, Boerckel, Joel D., additional, Bratt-Leal, Andres M., additional, Brown, James C., additional, Brubaker, Scott, additional, Brunette, Isabelle, additional, Calderon, Gisele A., additional, Caplan, Arnold I., additional, Castner, David G., additional, Chang, Cynthia, additional, Chawla, Aditya, additional, Chen, Xuguang, additional, Cohen, Paul, additional, Cooke, Michael J., additional, Copus, Joshua S., additional, Correlo, Vitor M., additional, Cox, Charles S., additional, Dahl, Abritee, additional, Day, Richard M., additional, De Coppi, Paolo, additional, Dodla, Mahesh C., additional, Elisseeff, Jennifer H., additional, Emamaullee, Juliet A., additional, Esa, Adam, additional, Fang, Yunlan, additional, Faust, Heather J., additional, Fisher, John P., additional, Fisher, Matthew B., additional, Francois, Elvis L., additional, García, Andrés J., additional, Gavrilov, Svetlana, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmiti, Christopher V., additional, Gillispie, Gregory J., additional, Gilpin, Sarah E., additional, Godbey, W.T., additional, Gray, Andrea, additional, Green, Ronald M., additional, Griffith, May, additional, Guldberg, Robert E., additional, Guo, Qiongyu, additional, Gurtner, Geoffrey C., additional, Hacker, Michael C., additional, Hanna, Issa A., additional, Hare, Joshua M., additional, Hatzistergos, Konstantinos E., additional, Herber, Ralf-Peter, additional, Hilborn, Jöns, additional, Humes, H. David, additional, Hunsberger, Joshua G., additional, Iwasa, Kenjiro, additional, Jackson, John D., additional, Jackson, Margaret L., additional, Jang, Hae Lin, additional, Jansen, John A., additional, Johnston, Josephine, additional, Jorns, Carl, additional, Kang, Huijun, additional, Kaplan, David L., additional, Kaplan, David S., additional, Katz, Adam J., additional, Kelley, Matthew W., additional, Kennedy, Kelsey, additional, Khademhosseini, Ali, additional, Khang, Gilson, additional, Kim, Jinho, additional, Klein, Rachel H., additional, Klimanskaya, Irina, additional, Knoepfler, Paul S., additional, Ko, In Kap, additional, Kolambkar, Yash M., additional, Krieghoff, Jan, additional, Kucko, Nathan W., additional, Kumar, Manoj, additional, Kurtzberg, Joanne, additional, Kwilas, Anna, additional, Landry, Donald W., additional, Langhans, Mark T., additional, Lanza, Robert, additional, Lanzoni, Giacomo, additional, Lee, Sang Jin, additional, Leeuwenburgh, Sander C.G., additional, Leong, Kam W., additional, Liang, Rui, additional, Liaudanskaya, Volha, additional, Lin, Hang, additional, Longaker, Michael T., additional, Lorenz, Hermann P., additional, Loring, Jeanne F., additional, Lu, Shi-Jiang, additional, Lue, Alberto, additional, Ma, Peter X., additional, Magalhaes, Renata S., additional, Mandla, Serena, additional, Marshall, Clement D., additional, Martins-Green, Manuela, additional, Mason, Devon E., additional, Mau, Jonquil R., additional, McFarland, Richard, additional, McHale, Melissa K., additional, Melville, James C., additional, Meyers, Jason R., additional, Mikos, Antonios G., additional, Miller, Jordan S., additional, Mittermiller, Paul A., additional, Miyachi, Hideki, additional, Miyamoto, Shinka, additional, Monteiro, Nelson, additional, Moore, Alessandra L., additional, Morini, Sara, additional, Moser, Philipp T., additional, Mukhatyar, Vivek J., additional, Murdock, Mark, additional, Nagiel, Aaron, additional, Naughton, Gail K., additional, Nauta, Allison, additional, Navarro, Javier, additional, Newton, Jared M., additional, Nori, Aparna, additional, Okano, Teruo, additional, Oliveira, Joaquim M., additional, Ott, Harald C., additional, Padmanabhan, Jagannath, additional, Page, Kristin M., additional, Pallickaveedu Rajan Asari, Anil Kumar, additional, Papaioannou, Virginia E., additional, Park, Jihoon, additional, Payne, Samantha L., additional, Pelled, Gadi, additional, Pepper, Andrew, additional, Perumal, Elumalai, additional, Petreaca, Melissa, additional, Pino, Christopher J., additional, Pirosa, Alessandro, additional, Pla-Palacín, Iris, additional, Pokrywczynska, Marta, additional, Porada, Christopher D., additional, Porter, Blaise D., additional, Radisic, Milica, additional, Rambhia, Kunal J., additional, Raquel Maia, F., additional, Ratner, Buddy D., additional, Reddi, A.H., additional, Reis, Rui L., additional, Ricles, Laura, additional, Ricordi, Camillo, additional, Rizwan, Muhammad, additional, Robinson, Rebecca, additional, Rodrigues, Melanie, additional, Rothrauff, Benjamin B., additional, Sadri-Ardekani, Hooman, additional, Sainz-Arnal, Pilar, additional, Sambathkumar, Rangarajan, additional, Sánchez-Romero, Natalia, additional, Scarritt, Michelle, additional, Schneider, Christopher M., additional, Schwartz, Steven D., additional, Selem, Sarah, additional, Serrano-Aulló, Trinidad, additional, Shapiro, A.M. James, additional, Sheyn, Dmitriy, additional, Shimizu, Tatsuya, additional, Shinoka, Toshiharu, additional, Shoichet, Molly S., additional, Shoji, Toshihiro, additional, Shupe, Thomas, additional, Sikora, Andrew G., additional, Simpson, Fiona, additional, Skardal, Aleksander, additional, Skuk, Daniel, additional, Smith, Brandon T., additional, Sohn, Jihee, additional, Soker, Shay, additional, Solanas, Estela, additional, Song, Jeong Eun, additional, Sood, Disha, additional, Stocum, David L., additional, Strom, Stephen C., additional, Sun, Jessica M., additional, Takahashi, Hironobu, additional, Tremblay, Jacques P., additional, Tripathy, Nirmalya, additional, Tse, John W., additional, Tuan, Rocky S., additional, Verfaillie, Catherine M., additional, Vunjak-Novakovic, Gordana, additional, Wagner, William R., additional, Wang, Yanling, additional, Watson, Emma, additional, West, Jennifer L., additional, Williams, David F., additional, Williams, James K., additional, Wong, Mark E., additional, Woo, Savio L-Y., additional, Wood, Fiona M., additional, Xu, Lei, additional, Yakubovich, Doron C., additional, Yang, Yafeng, additional, Yaszemski, Michael J., additional, Yelick, Pamela C., additional, Yim, Evelyn K.F., additional, Yong, Carolyn, additional, Yoo, James J., additional, Young, Simon, additional, Yucel, Nora, additional, Zacharias, Rachel L., additional, Zhang, Yuanyuan, additional, Zhang, Ai, additional, Zhang, Jin, additional, and Zhu, Yang, additional

Published
2018
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7. Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention

Author

Balestrieri, Maria Luisa, Lu, Shi-Jiang, de Nigris, Filomena, Giovane, Alfonso, Williams-Ignarro, Sharon, D’Armiento, Francesco Paolo, Feng, Qiang, Fiorito, Carmela, Testa, Gianluca, Pastore, Lucio, Cacciatore, Francesco, Mancini, Francesco Paolo, Servillo, Luigi, De Rosa, Gaetano, Pagliarulo, Caterina, Rienzo, Monica, Minucci, Pellegrino Biagio, Farzati, Bartolomeo, Salvatore, Francesco, Rengo, Franco, Ignarro, Louis Joseph, Giordano, Antonio, Baker, Andrew, Lanza, Robert, and Napoli, Claudio

Published
2010
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8. Reactive Metabolites from N-Nitrosamines

Author

Archer, Michael C., Milligan, Jamie R., Skotnicki, Sandra, Lu, Shi-Jiang, Witmer, Charlotte M., editor, Snyder, Robert R., editor, Jollow, David J., editor, Kalf, George F., editor, Kocsis, James J., editor, and Sipes, I. Glenn, editor

Published
1991
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9. Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

Author

Ying-Yi Zhang, Joseph Loscalzo, Bin Lu, Wen-Bin Wei, Chen Po-Hsuen, Lu Shi-Jiang, Qiang Feng, Shaomei Wang, Jorge S. Alfaro, and Jing-Yan Yang

Subjects
Retinal degeneration, intravitreal drug delivery, Retinal Ganglion Cells, genetic structures, trophic factors, Biomedical Engineering, Rodentia, Oncostatin M, Ciliary neurotrophic factor, Pharmacology, Retinal ganglion, Article, chemistry.chemical_compound, Neurotrophic factors, Retinitis pigmentosa, medicine, Animals, Humans, Ciliary Neurotrophic Factor, Progenitor cell, medicine.diagnostic_test, biology, business.industry, Retinal Degeneration, Retinal, medicine.disease, eye diseases, Rats, Ophthalmology, chemistry, biology.protein, Nanoparticles, neuroprotection, business, Electroretinography
Abstract

Purpose Retinitis pigmentosa (RP) is caused by mutations in more than 60 genes. Mutation-independent approaches to its treatment by exogeneous administration of neurotrophic factors that will preserve existing retinal anatomy and visual function are a rational strategy. Ciliary neurotrophic factor (CNTF) and oncostatin M (OSM) are two potent survival factors for neurons. However, growth factors degrade rapidly if administered directly. A sustained delivery of growth factors is required for translating their potential therapeutic benefit into patients. Methods Stable and biocompatible nanoparticles (NP) that incorporated with CNTF and OSM (CNTF- and OSM-NP) were formulated. Both NP-trophic factors were tested in vitro using photoreceptor progenitor cells (PPC) and retinal ganglion progenitor cells (RGPC) derived from induced pluripotent stem cells and in vivo using an optic nerve crush model for glaucoma and the Royal College of Surgeons rat, model of RP (n = 8/treatment) by intravitreal delivery. Efficacy was evaluated by electroretinography and optokinetic response. Retinal histology and a whole mount analysis were performed at the end of experiments. Results Significant prosurvival and pro-proliferation effects of both complexes were observed in both photoreceptor progenitor cells and RGPC in vitro. Importantly, significant RGC survival and preservation of vision and photoreceptors in both complex-treated animals were observed compared with control groups. Conclusions These results demonstrate that NP-trophic factors are neuroprotective both in vitro and in vivo. A single intravitreal delivery of both NP-trophic factors offered neuroprotection in animal models of retinal degeneration. Translational relevance Sustained nanoparticle delivery of neurotrophic factors may offer beneficial effects in slowing down progressive retinal degenerative conditions, including retinitis pigmentosa, age-related macular degeneration, and glaucoma.

Published
2021

17. List of Contributors

Author

Bowles, Robby D., primary, (Tony) Smith, Anthony J., additional, Ahlstrom, Jon D., additional, Albon, Julie, additional, Alexander, Peter G., additional, Altschuler, Richard A., additional, Alvarez, Pedro, additional, Amendola, A., additional, Anatol, Rachael, additional, Annabi, Nasim, additional, Anversa, Piero, additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Athanasiou, Kyriacos A., additional, Auger, François A., additional, Auguste, Debra T., additional, Awad, Hani A., additional, Badylak, Stephen F., additional, Bailey, Alexander M., additional, Barry, Michael P., additional, Becker, Daniel, additional, Belegu, Visar, additional, Bernhard, Jonathan, additional, Bertram, Timothy, additional, Besnard, Valérie, additional, Bhat, Z.F., additional, Bhat, Hina, additional, Bhatia, Sangeeta N., additional, Bhumiratana, Sarindr, additional, Bianco, Paolo, additional, Blackburn, Catherine Clare, additional, Bollenbach, Thomas, additional, Bonassar, Lawrence A., additional, Boulton, Mike, additional, Bradshaw, Amy D., additional, Breuer, Christopher K., additional, Brewster, Luke, additional, Brey, Eric M., additional, Brittan, Mairi, additional, Brown, Bryan N., additional, Brown, T., additional, Buckwalter, J.A., additional, Buffington, Deborah, additional, Burg, Karen J.L., additional, Burg, Timothy C., additional, Chabaud, Stéphane, additional, Swi Chang, Thomas Ming, additional, Chang, Yunchao, additional, Chapman, Robert G., additional, Chen, Fa-Ming, additional, Chen, Una, additional, Cimetta, Elisa, additional, Clark, Richard A.F., additional, Clark, Karen L., additional, Cleary, Muriel A., additional, Cloutier, Réjean, additional, Colton, Clark K., additional, Cotsarelis, George, additional, Crystal, Ronald G., additional, Dagnelie, Gislin, additional, da Silva Ferreira, Lino, additional, Davidson, Jeffrey M., additional, Deuel, Thomas F., additional, Direkze, Natalie, additional, Dressler, Gregory R., additional, Durfor, Charles N., additional, Duvall, Craig L., additional, Eng, George, additional, Engelmayr, George, additional, Eschenhagen, Thomas, additional, Eu-Kien Wong, Mark, additional, Falanga, Vincent, additional, Faria, Katie, additional, Faustman, Denise L., additional, Fauza, Dario O., additional, Feng, Qiang, additional, Ferreira, Lino, additional, Fink, Donald W., additional, Fissell, William, additional, Freed, Lisa E., additional, Furth, Mark E., additional, Gay, Denise, additional, Gerecht-Nir, Sharon, additional, Germain, Lucie, additional, Gersbach, Charles A., additional, Goulet, Francine, additional, Goyal, Ritu, additional, Grant, Maria B., additional, Greisler, Howard P., additional, Guilak, Farshid, additional, Harley, Brendan A.C., additional, Hart, David A., additional, Hmadcha, Abdelkrim, additional, Hodges, Steve J., additional, Hofer, Heidi R., additional, Hollinger, Jeffrey O., additional, Holobaugh, Patricia, additional, Hubbell, Jeffrey A., additional, Humes, H. David, additional, Ingber, Donald E., additional, Inskeep, Beau, additional, Jiang, Xingyu, additional, Kajstura, Jan, additional, Kane, Ravi S., additional, Karp, Jeffrey M., additional, Kasper, F. Kurtis, additional, Khademhosseini, Ali, additional, Kili, Sven, additional, Kimbrel, Erin A., additional, Klimanskaya, Irina, additional, Kohn, Joachim, additional, Kunisaki, Shaun M., additional, Kyriakides, Themis R., additional, Lagasse, Eric, additional, Lamontagne, Jean, additional, Langer, Robert, additional, Lanza, Robert, additional, Lecht, Shimon, additional, Lee, Benjamin W., additional, Lee, Chang H., additional, Lee, Mark H., additional, Lelkes, Peter I., additional, Leri, Annarosa, additional, Levine, David W., additional, Li, Feng, additional, Longaker, Michael T., additional, López, Javier, additional, Lu, Shi-Jiang, additional, Luo, Ying, additional, MacArthur, Ben D., additional, Manley, Nancy Ruth, additional, Manohar, Rohan, additional, Mansbridge, Jonathan, additional, Mantalaris, Athanasios, additional, Mao, Jeremy J., additional, Marsh, J.L., additional, Martin, David C., additional, Martin, J.A., additional, Martins-Green, M., additional, Masuda, Koichi, additional, Maxfield, Mark W., additional, McCabe, Kathryn L., additional, McDonald, John W., additional, McFarland, Richard, additional, Mikos, Antonios G., additional, Millán, José del R., additional, Miller, Josef M., additional, Mills, Shari, additional, Moffat, Kristen L., additional, Mondrinos, Mark J., additional, Montoro, Daniel T., additional, Moore, Malcolm A.S., additional, Neal, Rebekah A., additional, Nerem, Robert M., additional, Ng, Shengyong, additional, Nowell, Craig Scott, additional, Obokata, Haruko, additional, Olsen, Bjorn Reino, additional, Oreffo, Richard O.C., additional, O’Keefe, Regis J., additional, O’Neill, Kathy, additional, Ortiz, Ophir, additional, Pan, Carolyn K., additional, Pathak, Vikas, additional, Petreaca, M., additional, Pezzolla, Daniela, additional, Plikus, Maksim V., additional, Polak, Julia M., additional, Post, Mark, additional, Preston, Sean, additional, Prokop, Aleš, additional, Radisic, Milica, additional, Ranghini, Egon, additional, Raphael, Yehoash, additional, Reddi, A.H., additional, Reichenspurner, Herrmann, additional, Richie, Ellen, additional, Robey, Pamela Gehron, additional, Robinson, Becky, additional, Rojas, Anabel, additional, Roy, Shuvo, additional, Russell, Alan J., additional, Saigal, Rajiv, additional, Saltzman, W. Mark, additional, Samadikuchaksaraei, Ali, additional, Sambanis, Athanassios, additional, Schacht, Jochen, additional, Schutte, Stacey C., additional, Schutte, Lyndsey, additional, Schwartz, Steven D., additional, Schwartz, Robert E., additional, Setton, Lori A., additional, Sha, Su-Hua, additional, Shan, Jing, additional, Sharpe, Paul T., additional, Shi, Songtao, additional, Shrivats, Arun R., additional, Simon, Franck, additional, Sirabella, Dario, additional, Slack, J.M.W., additional, Soria, Bernat, additional, Spicer, Patrick, additional, Stevens, Kelly R., additional, Stockdale, Frank E., additional, Christiaan Stronks, H., additional, Studer, Lorenz, additional, Takayama, Shuichi, additional, Thomson, James A., additional, Trachtenberg, Jordan E., additional, Treffeisen, Elsa, additional, Tuan, Rocky S., additional, Vacanti, Charles A., additional, Vacanti, Joseph P., additional, van der Weele, Cor, additional, Vincent, Matthew, additional, Vunjak-Novakovic, Gordana, additional, Wahlberg, Lars U., additional, Wan, Derrick C., additional, Wang, Anne, additional, Westover, Angela J., additional, Whitesides, George M., additional, Whitsett, Jeffrey A., additional, Winitsky, Steve, additional, Witten, Celia, additional, Worgall, Stefan, additional, Wright, Nicholas A., additional, Yannas, Ioannis V., additional, Young, Simon, additional, Yu, Junying, additional, Zhang, Zheng, additional, Zheng, Wenfu, additional, Zimmermann, Wolfram Hubertus, additional, and Zoloth, Laurie, additional

Published
2014
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20. Contributors

Author

Anversa, Piero, primary, Arcidiacono, Judith, additional, Atala, Anthony, additional, Barrandon, Yann, additional, Batra, Ashok, additional, Becker, Daniel, additional, Bergmann, Nicole M., additional, Bianco, Paolo, additional, Blau, Helen M., additional, Bonner-Weir, Susan, additional, Brittan, Mairi, additional, Broxmeyer, Hal E., additional, Cananzi, Mara, additional, Caplan, Arnold I., additional, Cepko, Constance, additional, Colehour, Maegen, additional, Cossu, Giulio, additional, Daley, George Q., additional, Dang, Jiyoung M., additional, Dar, Ayelet, additional, Davis, Brian R., additional, Coppi, Paolo de, additional, Direkze, Natalie, additional, Domínguez-Bendala, Juan, additional, Dor, Yuval, additional, Dressler, Gregory R., additional, Durfor, Charles N., additional, Effros, Rita B., additional, Ellis, Ewa C.S., additional, Farley, Margaret A., additional, Fekete, Donna M., additional, Feng, Qiang, additional, Fink, Donald, additional, Fuchs, Elaine, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gerecht, Sharon, additional, Goldberg, Victor M., additional, Gonzalez, Rodolfo, additional, Gorostidi, François, additional, Gould, Elizabeth, additional, Grasset, Nicolas, additional, Grayeski, Deborah Lavoie, additional, Green, Ronald M., additional, Grompe, Markus, additional, Hare, Joshua M., additional, Hatzistergos, Konstantinos E., additional, Healy, Kevin E., additional, Hilbert, Stephen L., additional, Huang, Jerry I., additional, Huettner, James, additional, Imitola, Jaimie, additional, Irwin, Elizabeth F., additional, Itskovitz-Eldor, Joseph, additional, Johnston, Josephine, additional, Kajstura, Jan, additional, Kaplan, David S., additional, Katz, Adam J., additional, Kaur, Pritinder, additional, Kimbrel, Erin A., additional, Kimelman, Nadav, additional, Kintner, Chris, additional, Koyano-Nakagawa, Naoko, additional, Kunath, Tilo, additional, LaBarge, Mark A., additional, Lanza, Robert, additional, Lathion, Stéphanie, additional, Lazarus, Ellen, additional, Lee, Jean Pyo, additional, Lee, Mark H., additional, Leri, Annarosa, additional, Levine, S. Robert, additional, Li, Feng, additional, Lu, Shi-Jiang, additional, McDonald, John W., additional, McFarland, Richard, additional, McHale, Melissa K., additional, Melton, Douglas A., additional, Mericli, Alexander F., additional, Mirescu, Christian, additional, Moore, Malcolm A.S., additional, Moore, Mary Tyler, additional, Mueller, Franz-Josef, additional, Nadal-Ginard, Bernardo, additional, Ourednik, Jitka, additional, Ourednik, Vaclav, additional, Park, Kook I., additional, Pelled, Gadi, additional, Pileggi, Antonello, additional, Pollock, Jacob F., additional, Potten, Christopher S., additional, Preston, Sean, additional, Prokopishyn, Nicole L., additional, Ricordi, Camillo, additional, Robey, Pamela Gehron, additional, Rochat, Ariane, additional, Roelandt, Philip R., additional, Roobrouck, Valerie D., additional, Rosenthal, Nadia, additional, Rossant, Janet, additional, Sampaolesi, Maurilio, additional, Santini, Maria Paola, additional, Schaffer, David V., additional, Schlüter, Holger, additional, Schuch, Gunter, additional, Selem, Sarah, additional, Sheyn, Dima, additional, Sidman, Richard L., additional, Skuk, Daniel, additional, Snyder, Evan Y., additional, Soker, Shay, additional, Strom, Stephen C., additional, Studer, Lorenz, additional, Tedesco, Francesco Saverio, additional, Teng, Yang D., additional, Tremblay, Jacques P., additional, Tumbar, Tudorita, additional, Upjohn, Edward, additional, Varigos, George, additional, Verfaillie, Catherine M., additional, Wang, Zhan, additional, Weir, Gordon C., additional, West, Jennifer L., additional, Whittlesey, Kevin J., additional, Williams, J. Koudy, additional, Wilson, J.W., additional, Witten, Celia, additional, Wright, Nicholas A., additional, and Yoo, Jung U., additional

Published
2013
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23. Contributors

Author

Aboushwareb, Tamer, primary, Ahlstrom, Jon D., additional, Almarza, Alejandro J., additional, Anderson, James M., additional, Arcidiacono, Judith, additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Bae, Jae Hyun, additional, Ballios, Brian G., additional, Batra, Ashok, additional, Baumann, M. Douglas, additional, Bellamkonda, Ravi V., additional, Bergmann, Nicole M., additional, Bhatia, Mickie, additional, Birchall, Martin A., additional, Blau, Helen M., additional, Boerckel, Joel D., additional, Brivanlou, Ali H., additional, Cananzi, Mara, additional, Caplan, Arnold I., additional, Carnwath, Joseph W., additional, Challen, Grant A., additional, Christ, George J., additional, Chung, Hyun Jung, additional, Colehour, Maegen, additional, Cooke, Michael J., additional, Correlo, V.M., additional, Cosgrove, Benjamin D., additional, Da Sacco, Stefano, additional, Dang, Jiyoung M., additional, Day, Richard M., additional, De Coppi, Paolo, additional, De Filippo, Roger E., additional, Dodla, Mahesh C., additional, Domínguez-Bendala, Juan, additional, Dorin, Ryan P., additional, Durfor, Charles N., additional, Effros, Rita B., additional, Elisseeff, Jennifer H., additional, Ellis, Ewa C.S., additional, Emamaullee, Juliet A., additional, Fagerholm, Per, additional, Feng, Qiang, additional, Fink, Donald, additional, Fisher, Matthew B., additional, García, Andrés J., additional, Gavrilov, Svetlana, additional, Gazit, Dan, additional, Gazit, Zulma, additional, Gemmiti, Christopher V., additional, Gersbach, Charles A., additional, Goodell, Margaret A., additional, Grayeski, Deborah Lavoie, additional, Green, Ronald M., additional, Griffith, May, additional, Guldberg, Robert E., additional, Guo, Qiongyu, additional, Hacker, M.C., additional, Hackett, Joanne, additional, Hare, Joshua M., additional, Harrison, Benjamin S., additional, Hatzistergos, Konstantinos E., additional, Healy, Kevin E., additional, Hilbert, Stephen L., additional, Hu, Jiang, additional, Huber, Alexander, additional, Humes, H. David, additional, Irwin, Elizabeth F., additional, Isenberg, Brett C., additional, Iwata, Takanori, additional, Janes, Sam, additional, Jeng, Lily, additional, Ji, Junfeng, additional, Johnston, Josephine, additional, Johnston, Kimberly A., additional, Kaplan, David L., additional, Kaplan, David S., additional, Karaoglu, Sinan, additional, Katz, Adam J., additional, Kim, Jaehyun, additional, Kimbrel, Erin A., additional, Kimelman, Nadav, additional, Kluge, Jonathan A., additional, Koh, Chester J., additional, Kolambkar, Yash M., additional, Komura, Makoto, additional, Kues, Wilfried A., additional, Ng kee Kwong, Francois, additional, Lagali, Neil, additional, Lamba, Deepak A., additional, Landry, Donald W., additional, Lanza, Robert, additional, Larson, Barrett, additional, Latorre, Malcolm A., additional, Lazarus, Ellen, additional, Lee, Hyukjin, additional, Lee, Mark H., additional, Lee, Sang Jin, additional, Leisk, Gary G., additional, Li, Feng, additional, Liang, Rui, additional, Lin, Kuanyin K., additional, Liu, Xiaohua, additional, Longaker, Michael T., additional, Lorenz, H. Peter, additional, Lu, Shi-Jiang, additional, Lucas-Hahn, Andrea, additional, Ma, Peter X., additional, Macchiarini, Paolo, additional, Machingal, Masood A., additional, Mano, J.F., additional, Martins-Green, M., additional, McCall, Michael, additional, McFarland, Richard, additional, McHale, Melissa K., additional, Mericli, Alexander F., additional, Mikos, A.G., additional, Mukhatyar, Vivek J., additional, Nauta, Allison, additional, Neves, N.M., additional, Niemann, Heiner, additional, Okano, Teruo, additional, Okita, Keisuke, additional, Oliveira, J.M., additional, Papaioannou, Virginia E., additional, Park, Tae Gwan, additional, Pelled, Gadi, additional, Perin, Laura, additional, Petreaca, M., additional, Pileggi, Antonello, additional, Pollock, Jacob F., additional, Porter, Blaise D., additional, Radisic, Milica, additional, Rao, Nandini, additional, Reddi, A.H., additional, Reh, Thomas A., additional, Reis, R.L., additional, Ricordi, Camillo, additional, Roelandt, Philip, additional, Sangan, Caroline Beth, additional, Saul, Justin M., additional, Schaffer, David V., additional, Schuch, Gunter, additional, Sefton, Michael V., additional, Selem, Sarah, additional, Shapiro, A.M. James, additional, Sheardown, Heather, additional, Sheyn, Dima, additional, Shoichet, Molly S., additional, Singh, Harvir, additional, Sirivisoot, Sirinrath, additional, Skuk, Daniel, additional, Soker, Shay, additional, Spector, Myron, additional, Stocum, David L., additional, Strom, Stephen C., additional, Thomson, James A., additional, Tosh, David, additional, Tranquillo, Robert T., additional, Tremblay, Jacques P., additional, Verfaillie, Catherine M., additional, Wang, Zhan, additional, West, Jennifer L., additional, Whittlesey, Kevin J., additional, Williams, Chrysanthi, additional, Williams, David F., additional, Williams, J. Koudy, additional, Witten, Celia, additional, Woo, Savio L.-Y., additional, Wood, Fiona, additional, Yamanaka, Shinya, additional, Yamato, Masayuki, additional, Yazdani, Saami K., additional, Yoo, James J., additional, Yu, Junying, additional, and Zhong, Bonan, additional

Published
2011
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28. Red Blood Cells

Author

Lu, Shi-Jiang, primary, Park, Jennifer S., additional, Feng, Qiang, additional, and Lanza, Robert, additional

Published
2009
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29. Contributors

Author

Addis, Russell C., primary, Amit, Michal, additional, Andrews, Peter W., additional, Anversa, Piero, additional, Atala, Anthony, additional, Axelman, Joyce, additional, Bang, Anne G., additional, Barrandon, Yann, additional, Bauer, Steven R., additional, Becker, Daniel, additional, Benvenisty, Nissim, additional, Bianco, Paolo, additional, Blau, Helen M., additional, Bonner-Weir, Susan, additional, Brittan, Mairi, additional, Broxmeyer, Hal E., additional, Bultman, Scott, additional, Caplan, Arnold I., additional, Carpenter, Melissa K., additional, Cavaleri, Fatima, additional, Cepko, Connie, additional, Chang, Howard Y., additional, Chen, Xin, additional, Cheng, Tao, additional, Chuva de Sousa Lopes, Susana M., additional, Clark, Gregory O., additional, Clarke, Michael F., additional, Cossu, Giulio, additional, Crabbe, Annelies, additional, Daley, George Q., additional, Dar, Ayelet, additional, Davis, Brian R., additional, Direkze, Natalie C., additional, Dor, Yuval, additional, Draper, Jonathan S., additional, Dressler, Gregory R., additional, Evans, Martin, additional, Farley, Margaret A., additional, Fekete, Donna, additional, Feng, Qiang, additional, Field, Loren J., additional, Fink, Donald W., additional, Finley, K. Rose, additional, Fuchs, Elaine, additional, Fuller, Margaret T., additional, Gardner, Richard L., additional, Gearhart, John D., additional, Robey, Pamela Gehro., additional, Gerecht-Nir, Sharon, additional, Gilbert, Penney M., additional, Goldberg, Victor M., additional, Gonzalez, Rodolfo, additional, Gould, Elizabeth, additional, Graham, Trevor A., additional, Green, Ronald M., additional, Grompe, Markus, additional, Hockemeyer, Dirk, additional, Horb, Marko E., additional, Huang, Jerry I., additional, Humphries, Adam, additional, Itskovitz-Eldor, Joseph, additional, Jaenisch, Rudolf, additional, Johnson, Penny, additional, Jones, D. Leanne, additional, Kajstura, Jan, additional, Karsenty, Gerard, additional, Kaur, Pritinder, additional, Kent, Kathleen C., additional, Kerr, Candace L., additional, Khademhosseini, Ali, additional, Kintner, Chris, additional, Klimanskaya, Irina, additional, Koyano-Nakagawa, Naoko, additional, Kraszewski, Jennifer N., additional, Kunath, Tilo, additional, Langer, Robert, additional, Lanza, Robert, additional, Leri, Annarosa, additional, Levenberg, Shulamit, additional, Levine, S. Robert, additional, Lindvall, Olle, additional, Littlefield, John W., additional, Lu, Shi-Jiang, additional, Magnuson, Terry, additional, Mayshar, Yoav, additional, McDonald, John W., additional, McDonald, Stuart A.C., additional, McLaren, Anne, additional, McMahon, Jill, additional, Melton, Douglas A., additional, Mirescu, Christian, additional, Montgomery, Nathan, additional, Moore, Malcolm A.S., additional, Moore, Mary Tyle., additional, Mummery, Christine L., additional, Nagy, Andras, additional, Nishikawa, Satomi, additional, Nishikawa, Shin-Ichi, additional, Niwa, Hitoshi, additional, Park, Jennifer S., additional, Patterson, Ethan S., additional, Pébay, Alice, additional, Pera, Martin F., additional, Potten, Christopher S., additional, Poudel, Bhawana, additional, Preston, Sean L., additional, Prokopishyn, Nicole L., additional, Pugach, Emily K., additional, Lee, Jean Py., additional, Rochat, Ariane, additional, Rosenthal, Nadia, additional, Rossant, Janet, additional, Rothenberg, Michael, additional, Rubart, Michael, additional, Sacco, Alessandra, additional, Sampaolesi, Maurilio, additional, Santini, Maria Paol., additional, Scadden, David T., additional, Schöler, Hans, additional, Schulz, Tom, additional, Shamblott, Michael J., additional, Slayton, William B., additional, Snyder, Evan Y., additional, Soldner, Frank, additional, Spangrude, Gerald J., additional, Studer, Lorenz, additional, Surani, M. Azim, additional, Thomson, James A., additional, Tosh, David, additional, Tumbar, Tudorita, additional, Upjohn, Edward, additional, Varigos, George, additional, Verfaillie, Catherine M., additional, Weir, Gordon C., additional, Wilson, J.W., additional, Wright, Nicholas A., additional, Yamashita, Jun K., additional, Young, Holly, additional, Yu, Junying, additional, Zon, Leonard I., additional, and Zwaka, Thomas P., additional

Published
2009
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30. Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis

Author

Wang, Xiaofang, primary, Kimbrel, Erin A., additional, Ijichi, Kumiko, additional, Paul, Debayon, additional, Lazorchak, Adam S., additional, Chu, Jianlin, additional, Kouris, Nicholas A., additional, Yavanian, Gregory J., additional, Lu, Shi-Jiang, additional, Pachter, Joel S., additional, Crocker, Stephen J., additional, Lanza, Robert, additional, and Xu, Ren-He, additional

Published
2021
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39. The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo

Author

Yang, Xiaoming, Bani, Maria-Rosa, Lu, Shi-Jiang, Rowan, Sheldon, Ben-David, Yaacov, and Chabot, Benoit

Subjects
Mice -- Research, Nucleic acids -- Analysis, RNA splicing -- Analysis, Cell lines -- Research, Science and technology
Abstract

A study of mouse erythroleukemia cell line suggests that the heterogeneous nuclear ribonucleoparticle A1 protein supports distal 5' splice site (5'SS) selection and exon skipping that results in alternative splicing modulation. Transient representation of A1 or A1(super B) cDNA proteins in mouse erythroleukemia cells transfers 5'SS selection to a distal 9S donor center.

Published
1994

42. CAR‐NKcells from engineered pluripotent stem cells: Off‐the‐shelf therapeutics for all patients

Author

Lu, Shi‐Jiang and Feng, Qiang

Abstract

Clinical success of adoptive cell therapy with chimeric antigen receptor (CAR) T cells for treating hematological malignancies has revolutionized the field of cellular immunotherapy. However, due to the nature of utilizing autologous T cells, affordability and availability are major hurdles, in addition to scientific challenges relating to CAR‐T therapy optimization. Natural killer (NK) cell is a specialized immune effector cell type that recognizes and kills targets without human leukocyte antigen (HLA) restriction and prior sensitization. CAR‐NK cells do not cause graft vs host disease and can be obtained from unrelated donors as well as pluripotent stem cells (PSC), representing an ideal off‐the‐shelf therapeutics readily available for patients. Furthermore, unlike cytotoxic T cells, NK cells specifically target and eliminate cancer stem cells, which are the cells causing relapse and metastasis. PSCs can be genetically manipulated and engineered with CARs at the pluripotent stage, which allows the establishment of permanent, stable, and clonal PSC‐CAR lines for the manufacture of unlimited homogenous CAR‐NK cells. Multiple master PSC‐CAR cell banks targeting a variety of antigens for cancer, viral infection, and autoimmune diseases provide inexhaustible cell sources for all patients. Development of a next‐generation 3D bioreactor platform for PSC expansion and NK cell production overcomes major barriers related to cost and scalability for CAR‐NK product. The establishment of a master pluripotent stem cell (PSC)‐CAR cell bank targeting a variety of specific antigens will provide inexhaustible cell sources for the manufacture of truly off‐the‐shelf CAR‐NK cells for all patients of cancer, infectious, and autoimmune diseases.

Published
2021
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45. Contributors

Author

Agarwal, Rachit, Ahlstrom, Jon D., Ahmad, Rafiq, Alarcon, Emilio I., Almarza, Alejandro J., Almeida-Porada, Graça, Almeida, Manuel, Alvarado-Velez, Melissa, Anderson, James M., Arcidiacono, Judith, Atala, Anthony, Badylak, Stephen F., Balkan, Wayne, Ballios, Brian G., Baptista, Pedro M., Baumann, M. Douglas, Bedi, Supinder S., Bellamkonda, Ravi V., Bergmann, Nicole M., Blau, Helen M., Boerckel, Joel D., Bratt-Leal, Andres M., Brown, James C., Brubaker, Scott, Brunette, Isabelle, Calderon, Gisele A., Caplan, Arnold I., Castner, David G., Chang, Cynthia, Chawla, Aditya, Chen, Xuguang, Cohen, Paul, Cooke, Michael J., Copus, Joshua S., Correlo, Vitor M., Cox, Charles S., Jr., Dahl, Abritee, Day, Richard M., De Coppi, Paolo, Dodla, Mahesh C., Elisseeff, Jennifer H., Emamaullee, Juliet A., Esa, Adam, Fang, Yunlan, Faust, Heather J., Fisher, John P., Fisher, Matthew B., Francois, Elvis L., García, Andrés J., Gavrilov, Svetlana, Gazit, Dan, Gazit, Zulma, Gemmiti, Christopher V., Gillispie, Gregory J., Gilpin, Sarah E., Godbey, W.T., Gray, Andrea, Green, Ronald M., Griffith, May, Guldberg, Robert E., Guo, Qiongyu, Gurtner, Geoffrey C., Hacker, Michael C., Hanna, Issa A., Hare, Joshua M., Hatzistergos, Konstantinos E., Herber, Ralf-Peter, Hilborn, Jöns, Humes, H. David, Hunsberger, Joshua G., Iwasa, Kenjiro, Jackson, John D., Jackson, Margaret L., Jang, Hae Lin, Jansen, John A., Johnston, Josephine, Jorns, Carl, Kang, Huijun, Kaplan, David L., Kaplan, David S., Katz, Adam J., Kelley, Matthew W., Kennedy, Kelsey, Khademhosseini, Ali, Khang, Gilson, Kim, Jinho, Klein, Rachel H., Klimanskaya, Irina, Knoepfler, Paul S., Ko, In Kap, Kolambkar, Yash M., Krieghoff, Jan, Kucko, Nathan W., Kumar, Manoj, Kurtzberg, Joanne, Kwilas, Anna, Landry, Donald W., Langhans, Mark T., Lanza, Robert, Lanzoni, Giacomo, Lee, Sang Jin, Leeuwenburgh, Sander C.G., Leong, Kam W., Liang, Rui, Liaudanskaya, Volha, Lin, Hang, Longaker, Michael T., Lorenz, Hermann P., Loring, Jeanne F., Lu, Shi-Jiang, Lue, Alberto, Ma, Peter X., Magalhaes, Renata S., Mandla, Serena, Marshall, Clement D., Martins-Green, Manuela, Mason, Devon E., Mau, Jonquil R., McFarland, Richard, McHale, Melissa K., Melville, James C., Meyers, Jason R., Mikos, Antonios G., Miller, Jordan S., Mittermiller, Paul A., Miyachi, Hideki, Miyamoto, Shinka, Monteiro, Nelson, Moore, Alessandra L., Morini, Sara, Moser, Philipp T., Mukhatyar, Vivek J., Murdock, Mark, Nagiel, Aaron, Naughton, Gail K., Nauta, Allison, Navarro, Javier, Newton, Jared M., Nori, Aparna, Okano, Teruo, Oliveira, Joaquim M., Ott, Harald C., Padmanabhan, Jagannath, Page, Kristin M., Pallickaveedu Rajan Asari, Anil Kumar, Papaioannou, Virginia E., Park, Jihoon, Payne, Samantha L., Pelled, Gadi, Pepper, Andrew, Perumal, Elumalai, Petreaca, Melissa, Pino, Christopher J., Pirosa, Alessandro, Pla-Palacín, Iris, Pokrywczynska, Marta, Porada, Christopher D., Porter, Blaise D., Radisic, Milica, Rambhia, Kunal J., Raquel Maia, F., Ratner, Buddy D., Reddi, A.H., Reis, Rui L., Ricles, Laura, Ricordi, Camillo, Rizwan, Muhammad, Robinson, Rebecca, Rodrigues, Melanie, Rothrauff, Benjamin B., Sadri-Ardekani, Hooman, Sainz-Arnal, Pilar, Sambathkumar, Rangarajan, Sánchez-Romero, Natalia, Scarritt, Michelle, Schneider, Christopher M., Schwartz, Steven D., Selem, Sarah, Serrano-Aulló, Trinidad, Shapiro, A.M. James, Sheyn, Dmitriy, Shimizu, Tatsuya, Shinoka, Toshiharu, Shoichet, Molly S., Shoji, Toshihiro, Shupe, Thomas, Sikora, Andrew G., Simpson, Fiona, Skardal, Aleksander, Skuk, Daniel, Smith, Brandon T., Sohn, Jihee, Soker, Shay, Solanas, Estela, Song, Jeong Eun, Sood, Disha, Stocum, David L., Strom, Stephen C., Sun, Jessica M., Takahashi, Hironobu, Tremblay, Jacques P., Tripathy, Nirmalya, Tse, John W., Tuan, Rocky S., Verfaillie, Catherine M., Vunjak-Novakovic, Gordana, Wagner, William R., Wang, Yanling, Watson, Emma, West, Jennifer L., Williams, David F., Williams, James K., Wong, Mark E., Woo, Savio L-Y., Wood, Fiona M., Xu, Lei, Yakubovich, Doron C., Yang, Yafeng, Yaszemski, Michael J., Yelick, Pamela C., Yim, Evelyn K.F., Yong, Carolyn, Yoo, James J., Young, Simon, Yucel, Nora, Zacharias, Rachel L., Zhang, Yuanyuan, Zhang, Ai, Zhang, Jin, and Zhu, Yang

Published
2019
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48. Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components

Author

Kimbrel, Erin A. and Lu, Shi-Jiang

Subjects
Article Subject
Abstract

The ability of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to divide indefinitely without losing pluripotency and to theoretically differentiate into any cell type in the body makes them highly attractive cell sources for large scale regenerative medicine purposes. The current use of adult stem cell-derived products in hematologic intervention sets an important precedent and provides a guide for developing hESC/iPSC based therapies for the blood system. In this review, we highlight biological functions of mature cells of the blood, clinical conditions requiring the transfusion or stimulation of these cells, and the potential for hESC/iPSC-derivatives to serve as functional replacements. Many researchers have already been able to differentiate hESCs and/or iPSCs into specific mature blood cell types. For example, hESC-derived red blood cells and platelets are functional in tasks such as oxygen delivery and blood clotting, respectively and may be able to serve as substitutes for their donor-derived counterparts in emergencies. hESC-derived dendritic cells are functional in antigen-presentation and may be used as off-the-shelf vaccine therapies to stimulate antigen-specific immune responses against cancer cells. However, in vitro differentiation systems used to generate these cells will need further optimization before hESC/iPSC-derived blood components can be used clinically.

Published
2011
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