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Background Hepatocellular carcinoma (HCC) is the main pathological type of primary liver cancer (PLC) and is closely associated with Hepatitis B virus (HBV) infection. HCC in its early stages often presents no significant symptoms and is usually discovered at an advanced stage with liver, portal vein, or other site metastases, leading to a poor prognosis. Regular screening and early diagnosis in high-risk populations in the early stages of the disease are of great significance for clinical treatment and prognosis. Objective To explore the application value of oligosaccharides and alpha-fetoprotein (AFP) in the risk population and patients of HBV-related HCC, providing a reference for clinical diagnosis. Methods The study included 165 chronic HBV infection patients treated at the First Affiliated Hospital of Soochow University from January to November 2022, comprising 123 non-HCC and 42 HCC patients. Patient data (age, gender, cirrhosis status), laboratory indices[total bilirubin (TB), albumin (ALB), platelet count (PLT), AFP]were collected through electronic medical records, and a liver cancer risk prediction model score for chronic liver disease patients (aMAP score) was calculated, along with oligosaccharide marker test results (G-Test). HCC patients were classified as the HCC group (42 cases), and non-HCC patients were divided based on aMAP scores into low-risk (60 points, 39 cases) groups. Receiver operating characteristic (ROC) curves were plotted to analyze the efficacy of AFP, G-Test, and their combined diagnosis of HCC, calculating the area under the ROC curve (AUC), and the DeLong test was used to compare the differences between combined and single indicator AUCs. Kappa consistency tests were used to analyze the consistency of AFP and G-Test with clinical diagnostic results. Results In patients with HCC, levels of AFP and G-Test were higher compared to those in the low-risk, medium-risk, and high-risk groups (P

To systematically assess the effect of negative pressure wound therapy (NPWT) on postoperative surgical wound infection, length of hospital stay and postoperative complications after spinal surgery. Relevant studies on the application of NPWT in spinal surgery were conducted via a computerised database search, including PubMed, EMBASE, Web of Science, MEDLINE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang, from inception to June 2023. The identified literature was rigorously screened and data extraction was performed by two investigators independently. The quality of the relevant studies was evaluated using the Newcastle–Ottawa scale (NOS). The effect size for count data was determined by the odds ratio (OR), while the impact size for measurement data was expressed as the standardised mean difference (SMD). The 95% confidence interval (CI) was calculated for each effect magnitude. Stata 17.0 software was used for the meta‐analysis. Ten papers, totalling 1448 patients, were finally included. This study demonstrated that NPWT led to a statistically significant reduction in the occurrence of postoperative surgical wound infections (OR: 0.377, 95% CI: 0.238–0.598, p < 0.001), fewer postoperative complications (OR: 0.526, 95% CI: 0.360–0.770, p = 0.001) and a shortened hospital stay (SMD: −0.678, 95%CI: −1.324 to −0.031, p = 0.040) after spinal surgery compared with the control group. When compared with other treatment approaches, NPWT also demonstrated a substantial reduction in surgical wound infections and postoperative complications, as well as a shorter duration of hospitalisation after spinal surgery. [ABSTRACT FROM AUTHOR]

With the strengthening of external supervision and the management requirements of internal quality and efficiency improvement of power grid, it is particularly important to improve the lean level of power grid investment. However, the accuracy and scientificity of the current grid infrastructure project investment plan adjustment need to be further improved, and the basis for the completion of investment submission is the on-site construction progress. Therefore, this topic carries out the analysis of the factors affecting the construction progress, including the types of the factors affecting the construction, the depth and breadth of the impact, and the impact of the milestone stage, and takes the analysis results of the shutdown factors as the reference basis for the adjustment of the investment plan, so as to improve the investment management level of the company.

In order to deal with the severe external supervision and challenges, and improve the scientific rationality of internal investment structure decision-making, this study explored the idea of voltage level investment structure decision-making considering the power grid development and operation benefits. Firstly, based on the study of the relationship between historical investment scale and power grid indicators, the investment demand of power grid is determined; secondly, the influence path of investment on business efficiency is sorted out, and the differences of investment, capital transfer and depreciation of different voltage levels are studied and determined, and the operation benefit level of the company under different investment schemes is calculated. Finally, the index system of investment structure optimization is constructed to quantify the power grid and benefit status of the company under different investment structures, so as to optimize the company’s investment scheme and promote the high-quality development of the company and power grid.

The western mountain area of Hubei Province has obvious vertical climate and micro-climate features. It is a place where natural disasters occur frequently. The natural disasters have recently caused several large-scale and long-time power blackouts in the western mountain area of Hubei Province. This study analyses the damage to the power grid with voltage level from 220 to 10 kV in western Hubei Province caused by natural disasters from 2008 to 2016. The influence features of natural disasters on the western Hubei power grid are researched from four aspects, including natural disaster type, grid voltage level, occurrence time of natural disaster and line outage frequency. The causes of damage to the western Hubei power grid are studied from five aspects, including grid structure, design, equipment, construction, operation and maintenance. Also, the anti-disaster enhancement measures of the western Hubei power grid are proposed from the aspects of grid planning, design, equipment transformation, construction, operation and maintenance. The research results can provide a reference for other regional power grids to carry out research on resisting natural disasters and provide a guidance to improve anti-disaster ability of the power grid. [ABSTRACT FROM AUTHOR]

Nanomedicines have been widely used in colorectal cancer treatment, but their suboptimal targeting and deficient penetration capabilities remain obstacles in the delivery of therapeutics. In this study, inspired by the natural tumor tropism and intestinal invasion of Salmonella , we engineered highly biomimetic nanoparticles (SM-AuNRs) utilizing a Salmonella membrane to coat bacilliform Au nanorods. The engineered SM-AuNRs were able to mimic the germ's morphology and biological surface. SM-AuNRs containing the specific proteins inherited from the Salmonella membrane facilitated specific targeting and internalization into tumor cells. Meanwhile, SM-AuNRs with the rod-shaped morphology effectively traversed mucus barriers and tumor stroma. Due to the superior biological barrier penetrating and tumor targeting capabilities, doxorubicin-loaded SM-AuNRs with near-infrared laser irradiation displayed remarkable photothermal-chemotherapeutic antitumor effects in mouse orthotopic colorectal cancer models. Our findings pave the way for the design of bacteria-mimicking nanoparticles, presenting a promising avenue for the targeting and efficient treatment of colorectal cancer.