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112 results on '"Lu, S.H."'

11. Dabigatran versus vitamin K antagonists for atrial fibrillation in clinical practice: final outcomes from Phase III of the GLORIA-AF registry

Author

Huisman, M.V., Teutsch, C., Lu, S.H., Diener, H.C., Dubner, S.J., Halperin, J.L., Ma, C.S., Rothman, K.J., Lohmann, R., Gurusamy, V.K., Bartels, D.B., Lip, G.Y.H., and GLORIA-AF Investigators

Subjects
Vitamin K, Medizin, Myocardial Infarction, Administration, Oral, Anticoagulants, Hemorrhage, General Medicine, Atrial fibrillation, Dabigatran, Stroke, Anticoagulation, Clinical Trials, Phase III as Topic, Fibrinolytic Agents, Stroke prevention, Humans, Prospective Studies, Registries, Vitamin K antagonist, Cardiology and Cardiovascular Medicine, Aged
Abstract

Background Prospectively collected, routine clinical practice-based data on antithrombotic therapy in non-valvular atrial fibrillation (AF) patients are important for assessing real-world comparative outcomes. The objective was to compare the safety and effectiveness of dabigatran versus vitamin K antagonists (VKAs) in patients with newly diagnosed AF. Methods and results GLORIA-AF is a large, prospective, global registry program. Consecutive patients with newly diagnosed AF and CHA2DS2-VASc scores ≥ 1 were included and followed for 3 years. To control for differences in patient characteristics, the comparative analysis for dabigatran versus VKA was performed on a propensity score (PS)-matched patient set. Missing data were multiply imputed. Proportional-hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Between 2014 and 2016, 21,300 eligible patients were included worldwide: 3839 patients were prescribed dabigatran and 4836 VKA with a median age of 71.0 and 72.0 years, respectively; > 85% in each group had a CHA2DS2-VASc-score ≥ 2. The PS-matched comparative analysis for dabigatran and VKA included on average 3326 pairs of matched initiators. For dabigatran versus VKAs, adjusted HRs (95% confidence intervals) were: stroke 0.89 (0.59–1.34), major bleeding 0.61 (0.42–0.88), all-cause death 0.78 (0.63–0.97), and myocardial infarction 0.89 (0.53–1.48). Further analyses stratified by PS and region provided similar results. Conclusions Dabigatran was associated with a 39% reduced risk of major bleeding and 22% reduced risk for all-cause death compared with VKA. Stroke and myocardial infarction risks were similar, confirming a more favorable benefit-risk profile for dabigatran compared with VKA in clinical practice. Clinical trial registrationhttps://www.clinicaltrials.gov. NCT01468701, NCT01671007. Graphical abstract

Published
2022

26. Quantifying atmospheric nitrogen deposition through a nationwide monitoring network across China

Author

Xu, W., Luo, X.S., Pan, Y.P., Zhang, L., Tang, A.H., Shen, J.L., Zhang, Y., Li, K.H., Wu, Q.H., Yang, D.W., Zhang, Y.Y., Xue, J., Li, W.Q., Li, Q.Q., Tang, L., Lu, S.H., Liang, T., Tong, Y.A., Liu, P., Zhang, Q., Xiong, Z.Q., Shi, X.J., Wu, L.H., Shi, W.Q., Tian, K., Zhong, X.H., Shi, K., Tang, Q.Y., Zhang, L.J., Huang, J.L., He, C.E., Kuang, F.H., Zhu, B., Liu, H., Jin, X., Xin, Y.J., Shi, X.K., Du, E.Z., Dore, A.J., Tang, S., Collett Jr., J.L., Goulding, K., Sun, Y.X., Ren, J., Zhang, F.S., Liu, X.J., Xu, W., Luo, X.S., Pan, Y.P., Zhang, L., Tang, A.H., Shen, J.L., Zhang, Y., Li, K.H., Wu, Q.H., Yang, D.W., Zhang, Y.Y., Xue, J., Li, W.Q., Li, Q.Q., Tang, L., Lu, S.H., Liang, T., Tong, Y.A., Liu, P., Zhang, Q., Xiong, Z.Q., Shi, X.J., Wu, L.H., Shi, W.Q., Tian, K., Zhong, X.H., Shi, K., Tang, Q.Y., Zhang, L.J., Huang, J.L., He, C.E., Kuang, F.H., Zhu, B., Liu, H., Jin, X., Xin, Y.J., Shi, X.K., Du, E.Z., Dore, A.J., Tang, S., Collett Jr., J.L., Goulding, K., Sun, Y.X., Ren, J., Zhang, F.S., and Liu, X.J.

Abstract

A Nationwide Nitrogen Deposition Monitoring Network (NNDMN) containing 43 monitoring sites was established in China to measure gaseous NH3, NO2, and HNO3 and particulate NH4+ and NO3− in air and/or precipitation from 2010 to 2014. Wet/bulk deposition fluxes of Nr species were collected by precipitation gauge method and measured by continuous-flow analyzer; dry deposition fluxes were estimated using airborne concentration measurements and inferential models. Our observations reveal large spatial variations of atmospheric Nr concentrations and dry and wet/bulk Nr deposition. On a national basis, the annual average concentrations (1.3–47.0 μg N m−3) and dry plus wet/bulk deposition fluxes (2.9–83.3 kg N ha−1 yr−1) of inorganic Nr species are ranked by land use as urban > rural > background sites and by regions as north China > southeast China > southwest China > northeast China > northwest China > Tibetan Plateau, reflecting the impact of anthropogenic Nr emission. Average dry and wet/bulk N deposition fluxes were 20.6 ± 11.2 (mean ± standard deviation) and 19.3 ± 9.2 kg N ha−1 yr−1 across China, with reduced N deposition dominating both dry and wet/bulk deposition. Our results suggest atmospheric dry N deposition is equally important to wet/bulk N deposition at the national scale. Therefore, both deposition forms should be included when considering the impacts of N deposition on environment and ecosystem health.

Published
2015

32. An observational study on air quality in Lanzhou China

Author

Chu, Peter C., Chen, Y.C., Lu, S.H., Lu, Y., Li, Z., and Oceanography

Abstract

Sixth Symposium on Urban Environment, American Meteorological Society, Atlanta, January 30 - February 3, 2006. Contributed Paper

Published
2006

34. Title on document: Desert Self Supporting Mechanism

Author

Chu, Peter C., Lu, S.H., Chen, Y.C., and Oceanography

Abstract

Nineteenth Hydrology Conference, American Meteorological Society, San Diego, 9-13 January 2005. Contributed Paper

Published
2005

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