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24 results on '"Lu, Kristina T."'

1. U.S.-Japan cooperative medical sciences program: 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim

Author

Lu, Kristina T., Yamamoto, Takuya, McDonald, David, Li, Wei, Tan, Marissa, Moi, Meng Ling, Park, Eun-Chung, Yoshimatsu, Kumiko, Ricciardone, Marie, Hildesheim, Allan, Totsuka, Yukari, Nanbo, Asuka, Putcharoen, Opass, Suwanpimolkul, Gompol, Jantarabenjakul, Watsamon, Paitoonpong, Leilani, Handley, F. Gray, Bernabe, K. Gayle, Noda, Masahiko, Sonoda, Miwa, Brennan, Patrick, Griffin, Diane E., and Kurane, Ichiro

Published
2021
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7. 20th International Conference on Emerging Infectious Diseases in the Pacific Rim Organized by the United States-Japan Cooperative Medical Sciences Program (USJCMSP)

Author

Hepatitis, Immunology and Viral Diseases Panels, USJCMSP AIDS, ARI, Cancer,, primary, Bernabe, K. Gayle, additional, Lu, Kristina T., additional, Handley, F. Gray, additional, Griffin, Diane E., additional, Kurane, Ichiro, additional, Iwamoto, Aikichi, additional, Gao, George F., additional, and Krammer, Florian, additional

Published
2019
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9. Type I Interferon induces binding of STAT1 to Bcl6: Divergent Roles of STAT-family transcription factors in the TFH cell genetic program2

Author

Nakayamada, Shingo, Poholek, Amanda C., Lu, Kristina T., Takahashi, Hayato, Kato, Masanari, Iwata, Shigeru, Hirahara, Kiyoshi, Cannons, Jennifer L., Schwartzberg, Pamela L., Vahedi, Golnaz, Sun, Hong-wei, Kanno, Yuka, and O’Shea, John J.

Subjects
Mice, Knockout, Receptors, CXCR5, Programmed Cell Death 1 Receptor, Quantitative Trait Loci, T-Lymphocytes, Helper-Inducer, Article, DNA-Binding Proteins, Mice, STAT1 Transcription Factor, Gene Expression Regulation, Interferon Type I, Proto-Oncogene Proteins c-bcl-6, Animals, Cytokines
Abstract

CD4(+) T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although several cytokines including IL-6, IL-21, and IL-12 can promote TFH cell formation. Yet, none of these factors, nor their downstream cognate STATs, have emerged as nonredundant, essential drivers of TFH cells. This suggests a model in which multiple factors can contribute to the phenotypic characteristics of TFH cells. Because type I IFNs are often generated in immune responses, we set out to investigate whether these factors are relevant to TFH cell differentiation. Type I IFNs promote Th1 responses, thus one possibility was these factors antagonized TFH-expressed genes. However, we show that type I IFNs (IFN-α/β) induced B cell lymphoma 6 (Bcl6) expression, the master regulator transcription factor for TFH cells, and CXCR5 and programmed cell death-1 (encoded by Pdcd1), key surface molecules expressed by TFH cells. In contrast, type I IFNs failed to induce IL-21, the signature cytokine for TFH cells. The induction of Bcl6 was regulated directly by STAT1, which bound to the Bcl6, Cxcr5, and Pdcd1 loci. These data suggest that type I IFNs (IFN-α/β) and STAT1 can contribute to some features of TFH cells but are inadequate in inducing complete programming of this subset.

Published
2014

10. Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program

Author

Nakayamada, Shingo, primary, Poholek, Amanda C., additional, Lu, Kristina T., additional, Takahashi, Hayato, additional, Kato, Masanari, additional, Iwata, Shigeru, additional, Hirahara, Kiyoshi, additional, Cannons, Jennifer L., additional, Schwartzberg, Pamela L., additional, Vahedi, Golnaz, additional, Sun, Hong-wei, additional, Kanno, Yuka, additional, and O’Shea, John J., additional

Published
2014
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16. Structure-Function Relationships of Human C5a and C5aR

Author

Huber-Lang, Markus S., primary, Sarma, J. Vidya, additional, McGuire, Stephanie R., additional, Lu, Kristina T., additional, Padgaonkar, Vaishalee A., additional, Younkin, Ellen M., additional, Guo, Ren Feng, additional, Weber, Christian H., additional, Zuiderweg, Erik R., additional, Zetoune, Firas S., additional, and Ward, Peter A., additional

Published
2003
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17. Expression and Function of C5a Receptor in Mouse Microvascular Endothelial Cells

Author

Laudes, Ines J., primary, Chu, Jeffrey C., additional, Huber-Lang, Markus, additional, Guo, Ren-Feng, additional, Riedemann, Niels C., additional, Sarma, J. Vidya, additional, Mahdi, Fakhri, additional, Murphy, Hedwig S., additional, Speyer, Cecilia, additional, Lu, Kristina T., additional, Lambris, John D., additional, Zetoune, Firas S., additional, and Ward, Peter A., additional

Published
2002
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18. Generation of C5a by Phagocytic Cells

Author

Huber-Lang, Markus, primary, Younkin, Ellen M., additional, Sarma, J. Vidya, additional, Riedemann, Niels, additional, McGuire, Stephanie R., additional, Lu, Kristina T., additional, Kunkel, Robin, additional, Younger, John G., additional, Zetoune, Firas S., additional, and Ward, Peter A., additional

Published
2002
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19. Protection of innate immunity by C5aR antagonist in septic mice

Author

Huber‐Lang, Markus S., primary, Riedeman, Niels C., additional, Sarma, J. Vidya, additional, Younkin, Ellen M., additional, McGuire, Stephanie R., additional, Laudes, Ines J., additional, Lu, Kristina T., additional, Guo, Ren‐Feng, additional, Neff, Thomas A., additional, Padgaonkar, Vaishalee A., additional, Lambris, John D., additional, Spruce, L., additional, Mastellos, D., additional, Zetoune, Firas S., additional, and Ward, Peter A., additional

Published
2002
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20. Complement-Induced Impairment of Innate Immunity During Sepsis

Author

Huber-Lang, Markus S., primary, Younkin, Ellen M., additional, Sarma, J. Vidya, additional, McGuire, Stephanie R., additional, Lu, Kristina T., additional, Guo, Ren Feng, additional, Padgaonkar, Vaishalee A., additional, Curnutte, John T., additional, Erickson, Richard, additional, and Ward, Peter A., additional

Published
2002
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21. Protective effects of anti‐C5a peptide antibodies in experimental sepsis

Author

Huber‐Lang, Markus S., primary, Sarma, J. Vidya, additional, McGuire, Stephanie R., additional, Lu, Kristina T., additional, Guo, Ren Feng, additional, Padgaonkar, Vaishalee A., additional, Younkin, Ellen M., additional, Laudes, Ines J., additional, Riedemann, Niels C., additional, Younger, John G., additional, and Ward, Peter A., additional

Published
2001
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22. Role of C5a in Multiorgan Failure During Sepsis

Author

Huber-Lang, Markus, primary, Sarma, Vidya J., additional, Lu, Kristina T., additional, McGuire, Stephanie R., additional, Padgaonkar, Vaishalee A., additional, Guo, Ren-Feng, additional, Younkin, Ellen M., additional, Kunkel, Robin G., additional, Ding, Jiabing, additional, Erickson, Richard, additional, Curnutte, John T., additional, and Ward, Peter A., additional

Published
2001
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23. 20th International Conference on Emerging Infectious Diseases in the Pacific Rim Organized by the United States-Japan Cooperative Medical Sciences Program (USJCMSP).

Author

Bernabe, K. Gayle, Lu, Kristina T., Handley, F. Gray, Griffin, Diane E., Kurane, Ichiro, Iwamoto, Aikichi, Gao, George F., and Krammer, Florian

Subjects
MEDICAL sciences, AIDS, CONFERENCES & conventions, EMERGING infectious diseases, VIRUS diseases, RESPIRATORY infections
Abstract

The 20th International Conference on Emerging Infectious Diseases in the Pacific Rim to3ok place in Shenzhen, China on January 8–9, 2018 followed by meetings of the acquired immunodeficiency syndrome (AIDS)/immunology, acute respiratory infections, cancer, hepatitis, and viral diseases panels on January 10–11. The conference was organized as part of the United States-Japan Cooperative Medical Sciences Program (USJCMSP) by the Japan Agency for Medical Research and Development (AMED) and the U.S. National Institutes of Health (NIH) and was locally hosted by the Shenzhen Third People's Hospital and the Chinese Academy of Sciences (CAS) Institute of Microbiology. The conference provides the basis for networking and fostering of collaboration opportunities between researchers in Southeast Asia and the United States based on the scientific and interactive platform of the USJCMSP and takes place in the region on an annual basis. This report summarizes the discussions and conclusions from the conference. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Type I IFN Induces Binding of STAT1 to Bcl6: Divergent Roles of STAT Family Transcription Factors in the T Follicular Helper Cell Genetic Program.

Author

Shingo Nakayamada, Poholek, Amanda C., Lu, Kristina T., Hayato Takahashi, Masanari Kato, Shigeru Iwata, Kiyoshi Hirahara, Cannons, Jennifer L., Schwartzberg, Pamela L., Vahedi, Golnaz, Hong-wei Sun, Yuka Kanno, and O'Shea, John J.

Subjects
*CYTOKINES, *INTERFERONS, *CELLULAR immunity, *CELL differentiation, *TRANSCRIPTION factors, *ANTINEOPLASTIC agents
Abstract

CD4+ T follicular helper cells (TFH) are critical for the formation and function of B cell responses to infection or immunization, but also play an important role in autoimmunity. The factors that contribute to the differentiation of this helper cell subset are incompletely understood, although several cytokines including IL-6, IL-21, and IL-12 can promote TFH cell formation. Yet, none of these factors, nor their downstream cognate STATs, have emerged as nonredundant, essential drivers of TFH cells. This suggests a model in which multiple factors can contribute to the phenotypic characteristics of TFH cells. Because type I IFNs are often generated in immune responses, we set out to investigate whether these factors are relevant to TFH cell differentiation. Type I IFNs promote Th1 responses, thus one possibility was these factors antagonized TFH-expressed genes. However, we show that type I IFNs (IFN-α/β) induced B cell lymphoma 6 (Bcl6) expression, the master regulator transcription factor for TFH cells, and CXCR5 and programmed cell death-1 (encoded by Pdcd1), key surface molecules expressed by TFH cells. In contrast, type I IFNs failed to induce IL-21, the signature cytokine for TFH cells. The induction of Bcl6 was regulated directly by STAT1, which bound to the Bcl6, Cxcr5, and Pdcd1 loci. These data suggest that type I IFNs (IFN-α/β) and STAT1 can contribute to some features of TFH cells but are inadequate in inducing complete programming of this subset. [ABSTRACT FROM AUTHOR]

Published
2014
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