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19 results on '"Lu, Jingcai"'

6. Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice

Author

Bian, Lijun, primary, Zheng, Yu, additional, Guo, Xiaohong, additional, Li, Dongdong, additional, Zhou, Jingying, additional, Jing, Linyao, additional, Chen, Yan, additional, Lu, Jingcai, additional, Zhang, Ke, additional, Jiang, Chunlai, additional, Zhang, Yong, additional, and Kong, Wei, additional

Published
2022
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7. Respiratory Syncytial Virus F Subunit Vaccine With AS02 Adjuvant Elicits Balanced, Robust Humoral and Cellular Immunity in BALB/c Mice

Author

Zheng, Yu, primary, Bian, Lijun, additional, Zhao, Huiting, additional, Liu, Yulan, additional, Lu, Jingcai, additional, Liu, Dawei, additional, Zhang, Ke, additional, Song, Yueshuang, additional, Luo, Yusi, additional, Jiang, Chunlai, additional, Chen, Yan, additional, Zhang, Yong, additional, and Kong, Wei, additional

Published
2020
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12. Protective Immune Responses Elicited by Fusion Protein Containing PsaA and PspA Fragments

Author

Lu, Jingcai, primary, Sun, Tianxu, additional, Wang, Dandan, additional, Dong, Yunliang, additional, Xu, Man, additional, Hou, Hongjia, additional, Kong, Franklin T., additional, Liang, Chunsu, additional, Gu, Tiejun, additional, Chen, Pinxu, additional, Sun, Shiyang, additional, Lv, Xiuping, additional, Jiang, Chunlai, additional, Kong, Wei, additional, and Wu, Yongge, additional

Published
2015
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13. Immunogenicity and protective efficacy of an EV71 virus-like particle vaccine against lethal challenge in newborn mice

Author

Sun, Shiyang, primary, Gao, Fan, additional, Mao, Qunying, additional, Shao, Jie, additional, Jiang, Liping, additional, Liu, Dawei, additional, Wang, Yiping, additional, Yao, Xin, additional, Wu, Xing, additional, Sun, Bo, additional, Zhao, Dandan, additional, Ma, Youlei, additional, Lu, Jingcai, additional, Kong, Wei, additional, Jiang, Chunlai, additional, and Liang, Zhenglun, additional

Published
2015
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14. Evaluation of monovalent and bivalent vaccines against lethalEnterovirus71 andCoxsackievirusA16 infection in newborn mice

Author

Sun, Shiyang, primary, Jiang, Liping, additional, Liang, Zhenglun, additional, Mao, Qunying, additional, Su, Weiheng, additional, Zhang, Huafei, additional, Li, Xiaojun, additional, Jin, Jun, additional, Xu, Lin, additional, Zhao, Dandan, additional, Fan, Peihu, additional, An, Dong, additional, Yang, Ping, additional, Lu, Jingcai, additional, Lv, Xiuping, additional, Sun, Bo, additional, Xu, Fei, additional, Kong, Wei, additional, and Jiang, Chunlai, additional

Published
2014
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15. Detoxified pneumolysin derivative plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines

Author

Lu, Jingcai, primary, Sun, Tianxu, additional, Hou, Hongjia, additional, Xu, Man, additional, Gu, Tiejun, additional, Dong, Yunliang, additional, Wang, Dandan, additional, Chen, Pinxu, additional, Wu, Chunlai, additional, Liang, Chunshu, additional, Sun, Shiyang, additional, Jiang, Chunlai, additional, Kong, Wei, additional, and Wu, Yongge, additional

Published
2014
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19. Evaluation of monovalent and bivalent vaccines against lethal Enterovirus71 and CoxsackievirusA16 infection in newborn mice

Author

Sun, Shiyang, Jiang, Liping, Liang, Zhenglun, Mao, Qunying, Su, Weiheng, Zhang, Huafei, Li, Xiaojun, Jin, Jun, Xu, Lin, Zhao, Dandan, Fan, Peihu, An, Dong, Yang, Ping, Lu, Jingcai, Lv, Xiuping, Sun, Bo, Xu, Fei, Kong, Wei, and Jiang, Chunlai

Abstract

Enterovirus71 (EV71) and CoxsackievirusA16 (CVA16) have caused severe epidemics of hand, foot and mouth disease (HFMD) in the Asia Pacific in recent years, particularly in infants and young children. This disease has become a serious public health problem, as no vaccines or antiviral drugs have been approved for EV71 and CA16 infections. In this study, we compared four monovalent vaccines, including formalin-inactivated EV71 virus (iEV71), EV71 virus-like particles (VLPs) (vEV71), formalin-inactivated CVA16 virus (iCVA16) and CVA16 VLPs (vCVA16), along with two bivalent vaccines, including equivalent doses of formalin-inactivated EV71+CVA16 virus (iEV71+iCVA16) and EV71+CVA16 VLPs (vEV71+vCVA16). The IgG titers and neutralization antibodies titers demonstrated that there are no immune interference exists between the two immunogens of EV71 and CVA16. IgG subclass isotyping revealed that IgG1 and IgG2b were induced primarily in all vaccine groups. Furthermore, cross-neutralization antibodies were elicited in mouse sera against other sub-genotypes of EV71 and CVA16. In vivo challenge experiments showed that the immune sera from vaccinated animals could confer passive protection to newborn mice against lethal challenge with 14 LD50of EV71 and 50 LD50of CVA16. Our results indicated that bivalent vaccination is promising for HFMD vaccine development. With the advantage of having a better safety profile than inactivated virus vaccines, VLPs should be used to combine both EV71 and CVA16 antigens as a candidate vaccine for prevention of HFMD virus transmission.

Published
2014
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