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Your search keyword '"Lu, C. (Chao)"' showing total 4 results
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4 results on '"Lu, C. (Chao)"'

1. Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

Author

Prins, B.P. (Bram. P.), Abbasi, A. (Ali), Wong, A. (Anson), Vaez, A. (Ahmad), Nolte, I.M. (Ilja), Franceschini, N. (Nora), Stuart, P.E. (Philip E.), Guterriez Achury, J. (Javier), Mistry, V. (Vanisha), Bradfield, J.P. (Jonathan), Valdes, A.M. (Ana Maria), Bras, J. (Jose), Shatunov, A. (Aleksey), Lu, C. (Chao), Han, B. (Buhm), Raychaudhuri, S. (Soumya), Bevan, S. (Steve), Mayes, M.D. (Maureen D.), Tsoi, L.C. (Lam C.), Evangelou, E. (Evangelos), Nair, R.P. (Rajan P.), Grant, S.F.A. (Struan), Polychronakos, C. (Constantin), Radstake, T.R.D.J. (Timothy), Heel, D.A. (David) van, Dunstan, M.L., Wood, N.W. (Nicholas), Al-Chalabi, A. (Ammar), Dehghan, A. (Abbas), Hakonarson, H. (Hakon), Markus, H.S. (Hugh S.), Elder, J.T. (James), Knight, J. (Jo), Arking, D.E. (Dan), Spector, T.D. (Timothy), Koeleman, B.P.C. (Bobby), Duijn, C.M. (Cornelia) van, Martín, J. (Javier), Morris, A.P. (Andrew), Weersma, R.K. (Rinse K.), Wijmenga, C. (Cisca), Munroe, P. (Patricia), Perry, J.R.B. (John), Pouget, J.G. (Jennie G.), Jamshidi, Y. (Yalda), Snieder, H. (Harold), Alizadeh, B.Z. (Behrooz), Prins, B.P. (Bram. P.), Abbasi, A. (Ali), Wong, A. (Anson), Vaez, A. (Ahmad), Nolte, I.M. (Ilja), Franceschini, N. (Nora), Stuart, P.E. (Philip E.), Guterriez Achury, J. (Javier), Mistry, V. (Vanisha), Bradfield, J.P. (Jonathan), Valdes, A.M. (Ana Maria), Bras, J. (Jose), Shatunov, A. (Aleksey), Lu, C. (Chao), Han, B. (Buhm), Raychaudhuri, S. (Soumya), Bevan, S. (Steve), Mayes, M.D. (Maureen D.), Tsoi, L.C. (Lam C.), Evangelou, E. (Evangelos), Nair, R.P. (Rajan P.), Grant, S.F.A. (Struan), Polychronakos, C. (Constantin), Radstake, T.R.D.J. (Timothy), Heel, D.A. (David) van, Dunstan, M.L., Wood, N.W. (Nicholas), Al-Chalabi, A. (Ammar), Dehghan, A. (Abbas), Hakonarson, H. (Hakon), Markus, H.S. (Hugh S.), Elder, J.T. (James), Knight, J. (Jo), Arking, D.E. (Dan), Spector, T.D. (Timothy), Koeleman, B.P.C. (Bobby), Duijn, C.M. (Cornelia) van, Martín, J. (Javier), Morris, A.P. (Andrew), Weersma, R.K. (Rinse K.), Wijmenga, C. (Cisca), Munroe, P. (Patricia), Perry, J.R.B. (John), Pouget, J.G. (Jennie G.), Jamshidi, Y. (Yalda), Snieder, H. (Harold), and Alizadeh, B.Z. (Behrooz)

Abstract

Background: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. Methods and Findings: We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the second consisted of 18 SNPs that were significantly associated with CRP levels in the largest genome-wide association study (GWAS) to date (GRSGWAS). To optimize power, we used summ

Published
2016
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2. Wideband-adjustable reflection-suppressed rejection filters using chirped and tilted fiber gratings

Author

Liu, F. (Fu), Guo, T. (Tuan), Wu, C. (Chuang), Guan, B.-O. (Bai-Ou), Lu, C. (Chao), Tam, H.-Y. (Hwa-Yaw), Albert, J. (Jacques), Liu, F. (Fu), Guo, T. (Tuan), Wu, C. (Chuang), Guan, B.-O. (Bai-Ou), Lu, C. (Chao), Tam, H.-Y. (Hwa-Yaw), and Albert, J. (Jacques)

Abstract

Wideband-adjustable band-rejection filters based on chirped and tilted fiber Bragg gratings (CTFBG) are proposed and experimentally demonstrated. The flexible chirp-rate and wide tilt-angle provide the gratings with broadband filtering functions over a large range of bandwidths (from 10 nm to 150 nm), together with a low insertion loss (less than 1dB) and a negligible back-reflection (lower than -20 dB). The slope profile of CTFBG in transmission can be easily tailored by adjusting the tilt angle, grating irradiation time and chirp rate-grating factor, and it is insensitive to the polarization state of the input light, as well as to temperature, axial strain and surrounding refractive index. Furthermore, by coating the CTFBG with a suitable polymer (whose refractive index is close to that of the cladding glass), the cladding modes no longer form wea

Published
2014
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3. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

Author

Ho, J.E. (Jennifer), Chen, W.-Y. (Wei-Yu), Chen, M-H. (Ming-Huei), Larson, M.G. (Martin), McCabe, M. (Marita), Cheng, S. (Susan), Ghorbani, A. (Anahita), Coglianese, E. (Erin), Emilsson, V. (Valur), Johnson, A.D. (Andrew), Walter, S. (Stefan), Franceschini, N. (Nora), O'Donnell, C.J. (Christopher), Dehghan, A. (Abbas), Lu, C. (Chao), Levy, D. (Daniel), Newton-Cheh, C. (Christopher), Lin, H. (Honghuang), Felix, J.F. (Janine), Schreiter, E.R. (Eric), Vasan, R.S. (Ramachandran Srini), Januzzi, J.L. (James), Lee, R.T. (Richard), Wang, T.J. (Thomas), Ho, J.E. (Jennifer), Chen, W.-Y. (Wei-Yu), Chen, M-H. (Ming-Huei), Larson, M.G. (Martin), McCabe, M. (Marita), Cheng, S. (Susan), Ghorbani, A. (Anahita), Coglianese, E. (Erin), Emilsson, V. (Valur), Johnson, A.D. (Andrew), Walter, S. (Stefan), Franceschini, N. (Nora), O'Donnell, C.J. (Christopher), Dehghan, A. (Abbas), Lu, C. (Chao), Levy, D. (Daniel), Newton-Cheh, C. (Christopher), Lin, H. (Honghuang), Felix, J.F. (Janine), Schreiter, E.R. (Eric), Vasan, R.S. (Ramachandran Srini), Januzzi, J.L. (James), Lee, R.T. (Richard), and Wang, T.J. (Thomas)

Abstract

The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response when bound to its ligand, IL-33. The other isoform is a soluble protein (sST2) that is thought to be a decoy receptor for IL-33 signaling. Elevated sST2 levels in serum are associated with an increased risk for cardiovascular disease. We investigated the determinants of sST2 plasma concentrations in 2, 991 Framingham Offspring Cohort participants. While clinical and environmental factors explained some variation in sST2 levels, much of the variation in sST2 production was driven by genetic factors. In a genome-wide association study (GWAS), multiple SNPs within IL1RL1 (the gene encoding ST2) demonstrated associations with sST2 concentrations. Five missense variants of IL1RL1 correlated with higher sST2 levels in the GWAS and mapped to the intracellular domain of ST2, which is absent in sST2. In a cell culture model, IL1RL1 missense variants increased sST2 expression by inducing IL-33 expression and enhancing IL-33 responsiveness (via ST2L). Our data suggest that genetic variation in IL1RL1 can result in increased levels of sST2 and alter immune and inflammatory signaling through the ST2/IL-33 pathway.

Published
2013
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4. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels

Author

Barbalic, M. (maja), Dupuis, J. (Josée), Dehghan, A. (Abbas), Bis, J.C. (Joshua), Hoogeveen, R.C. (Ron), Schnabel, R. (Renate), Nambi, V. (Vijay), Bretler, M. (Monique), Smith, N.L. (Nicholas), Peters, A. (Annette), Lu, C. (Chao), Tracy, R.P. (Russell), Aleksic, N. (Nena), Heeriga, J. (Jan), Keaney, J.F. (John), Rice, K. (Kenneth), Lip, G.Y. (Gregory), Vasan, R.S. (Ramachandran Srini), Glazer, N.L. (Nicole), Larson, M.G. (Martin), Uitterlinden, A.G. (André), Yamamoto, J.F. (Jennifer), Durda, P. (Peter), Haritunians, T. (Talin), Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), Hofman, A. (Albert), Koenig, W. (Wolfgang), Jenny, N.S. (Nancy), Witteman, J.C.M. (Jacqueline), Ballantyne, C. (Christie), Benjamin, E.J. (Emelia), Barbalic, M. (maja), Dupuis, J. (Josée), Dehghan, A. (Abbas), Bis, J.C. (Joshua), Hoogeveen, R.C. (Ron), Schnabel, R. (Renate), Nambi, V. (Vijay), Bretler, M. (Monique), Smith, N.L. (Nicholas), Peters, A. (Annette), Lu, C. (Chao), Tracy, R.P. (Russell), Aleksic, N. (Nena), Heeriga, J. (Jan), Keaney, J.F. (John), Rice, K. (Kenneth), Lip, G.Y. (Gregory), Vasan, R.S. (Ramachandran Srini), Glazer, N.L. (Nicole), Larson, M.G. (Martin), Uitterlinden, A.G. (André), Yamamoto, J.F. (Jennifer), Durda, P. (Peter), Haritunians, T. (Talin), Psaty, B.M. (Bruce), Boerwinkle, E.A. (Eric), Hofman, A. (Albert), Koenig, W. (Wolfgang), Jenny, N.S. (Nancy), Witteman, J.C.M. (Jacqueline), Ballantyne, C. (Christie), and Benjamin, E.J. (Emelia)

Abstract

P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-selectin) and ICAM-1 (sICAM-1), we performed a genome-wide association study in a sample of 4115 (sP-selectin) and 9813 (sICAM-1) individuals of European ancestry as a part of The Cohorts for Heart and Aging Research in Genome Epidemiology consortium. The most significant SNP association for sP-selectin was within the SELP gene (rs6136, P = 4.05 × 10-61) and for sICAM-1 levels within the ICAM-1 gene (rs3093030, P = 3.53 × 10-23). Both sP-selectin and sICAM-1 were associated with ABO gene variants (rs579459, P = 1.86 × 10-41and rs649129, P = 1.22 × 10-15, respectively) and in both cases the observed associations could be accounted for by the A1 allele of the ABO blood group. The absence of an association between ABO blood group and platelet-bound P-selectin levels in an independent subsample (N = 1088) from the ARIC study, suggests that the ABO blood group may influence cleavage of the P-selectin protein from the cell surface or clearance from the circulation, rather than its production and cellular presentation. These results provide new insights into adhesion molecule

Published
2010
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