Search

While electroencephalogram (EEG) based brain-computer interface (BCI) has been widely used for medical diagnosis, health care, and device control, the safety of EEG BCI has long been neglected. In this paper, we propose Professor X, an invisible and robust "mind-controller" that can arbitrarily manipulate the outputs of EEG BCI through backdoor attack, to alert the EEG community of the potential hazard. However, existing EEG attacks mainly focus on single-target class attacks, and they either require engaging the training stage of the target BCI, or fail to maintain high stealthiness. Addressing these limitations, Professor X exploits a three-stage clean label poisoning attack: 1) selecting one trigger for each class; 2) learning optimal injecting EEG electrodes and frequencies strategy with reinforcement learning for each trigger; 3) generating poisoned samples by injecting the corresponding trigger's frequencies into poisoned data for each class by linearly interpolating the spectral amplitude of both data according to previously learned strategies. Experiments on datasets of three common EEG tasks demonstrate the effectiveness and robustness of Professor X, which also easily bypasses existing backdoor defenses., Comment: 27 pages,13 figures

Recent advancements for large-scale pre-training with neural signals such as electroencephalogram (EEG) have shown promising results, significantly boosting the development of brain-computer interfaces (BCIs) and healthcare. However, these pre-trained models often require full fine-tuning on each downstream task to achieve substantial improvements, limiting their versatility and usability, and leading to considerable resource wastage. To tackle these challenges, we propose NeuroLM, the first multi-task foundation model that leverages the capabilities of Large Language Models (LLMs) by regarding EEG signals as a foreign language, endowing the model with multi-task learning and inference capabilities. Our approach begins with learning a text-aligned neural tokenizer through vector-quantized temporal-frequency prediction, which encodes EEG signals into discrete neural tokens. These EEG tokens, generated by the frozen vector-quantized (VQ) encoder, are then fed into an LLM that learns causal EEG information via multi-channel autoregression. Consequently, NeuroLM can understand both EEG and language modalities. Finally, multi-task instruction tuning adapts NeuroLM to various downstream tasks. We are the first to demonstrate that, by specific incorporation with LLMs, NeuroLM unifies diverse EEG tasks within a single model through instruction tuning. The largest variant NeuroLM-XL has record-breaking 1.7B parameters for EEG signal processing, and is pre-trained on a large-scale corpus comprising approximately 25,000-hour EEG data. When evaluated on six diverse downstream datasets, NeuroLM showcases the huge potential of this multi-task learning paradigm., Comment: 22 pages, 11 figures

Retrosynthesis analysis is pivotal yet challenging in drug discovery and organic chemistry. Despite the proliferation of computational tools over the past decade, AI-based systems often fall short in generalizing across diverse reaction types and exploring alternative synthetic pathways. This paper presents BatGPT-Chem, a large language model with 15 billion parameters, tailored for enhanced retrosynthesis prediction. Integrating chemical tasks via a unified framework of natural language and SMILES notation, this approach synthesizes extensive instructional data from an expansive chemical database. Employing both autoregressive and bidirectional training techniques across over one hundred million instances, BatGPT-Chem captures a broad spectrum of chemical knowledge, enabling precise prediction of reaction conditions and exhibiting strong zero-shot capabilities. Superior to existing AI methods, our model demonstrates significant advancements in generating effective strategies for complex molecules, as validated by stringent benchmark tests. BatGPT-Chem not only boosts the efficiency and creativity of retrosynthetic analysis but also establishes a new standard for computational tools in synthetic design. This development empowers chemists to adeptly address the synthesis of novel compounds, potentially expediting the innovation cycle in drug manufacturing and materials science. We release our trial platform at \url{https://www.batgpt.net/dapp/chem}.

With the rapid advancement in machine learning, the recognition and analysis of brain activity based on EEG and eye movement signals have attained a high level of sophistication. Utilizing deep learning models for learning EEG and eye movement features proves effective in classifying brain activities. A focused state indicates intense concentration on a task or thought. Distinguishing focused and unfocused states can be achieved through eye movement behaviors, reflecting variations in brain activities. By calculating binocular focusing point disparity in eye movement signals and integrating relevant EEG features, we propose an annotation method for focused states. The resulting comprehensive dataset, derived from raw data processed through a bio-acquisition device, includes both EEG features and focused labels annotated by eye movements. Extensive training and testing on several deep learning models, particularly the Transformer, yielded a 90.16% accuracy on the subject-dependent experiments. The validity of this approach was demonstrated, with cross-subject experiments, key frequency band and brain region analyses confirming its generalizability and providing physiological explanations.

The current electroencephalogram (EEG) based deep learning models are typically designed for specific datasets and applications in brain-computer interaction (BCI), limiting the scale of the models and thus diminishing their perceptual capabilities and generalizability. Recently, Large Language Models (LLMs) have achieved unprecedented success in text processing, prompting us to explore the capabilities of Large EEG Models (LEMs). We hope that LEMs can break through the limitations of different task types of EEG datasets, and obtain universal perceptual capabilities of EEG signals through unsupervised pre-training. Then the models can be fine-tuned for different downstream tasks. However, compared to text data, the volume of EEG datasets is generally small and the format varies widely. For example, there can be mismatched numbers of electrodes, unequal length data samples, varied task designs, and low signal-to-noise ratio. To overcome these challenges, we propose a unified foundation model for EEG called Large Brain Model (LaBraM). LaBraM enables cross-dataset learning by segmenting the EEG signals into EEG channel patches. Vector-quantized neural spectrum prediction is used to train a semantically rich neural tokenizer that encodes continuous raw EEG channel patches into compact neural codes. We then pre-train neural Transformers by predicting the original neural codes for the masked EEG channel patches. The LaBraMs were pre-trained on about 2,500 hours of various types of EEG signals from around 20 datasets and validated on multiple different types of downstream tasks. Experiments on abnormal detection, event type classification, emotion recognition, and gait prediction show that our LaBraM outperforms all compared SOTA methods in their respective fields. Our code is available at https://github.com/935963004/LaBraM., Comment: The Twelfth International Conference on Learning Representations

Seeing is believing, however, the underlying mechanism of how human visual perceptions are intertwined with our cognitions is still a mystery. Thanks to the recent advances in both neuroscience and artificial intelligence, we have been able to record the visually evoked brain activities and mimic the visual perception ability through computational approaches. In this paper, we pay attention to visual stimuli reconstruction by reconstructing the observed images based on portably accessible brain signals, i.e., electroencephalography (EEG) data. Since EEG signals are dynamic in the time-series format and are notorious to be noisy, processing and extracting useful information requires more dedicated efforts; In this paper, we propose a comprehensive pipeline, named NeuroImagen, for reconstructing visual stimuli images from EEG signals. Specifically, we incorporate a novel multi-level perceptual information decoding to draw multi-grained outputs from the given EEG data. A latent diffusion model will then leverage the extracted information to reconstruct the high-resolution visual stimuli images. The experimental results have illustrated the effectiveness of image reconstruction and superior quantitative performance of our proposed method., Comment: A preprint version of an ongoing work

Current graph neural networks (GNNs) lack generalizability with respect to scales (graph sizes, graph diameters, edge weights, etc..) when solving many graph analysis problems. Taking the perspective of synthesizing graph theory programs, we propose several extensions to address the issue. First, inspired by the dependency of the iteration number of common graph theory algorithms on graph size, we learn to terminate the message passing process in GNNs adaptively according to the computation progress. Second, inspired by the fact that many graph theory algorithms are homogeneous with respect to graph weights, we introduce homogeneous transformation layers that are universal homogeneous function approximators, to convert ordinary GNNs to be homogeneous. Experimentally, we show that our GNN can be trained from small-scale graphs but generalize well to large-scale graphs for a number of basic graph theory problems. It also shows generalizability for applications of multi-body physical simulation and image-based navigation problems., Comment: To appear at NeurIPS 2020

Standard neural machine translation (NMT) is on the assumption of document-level context independent. Most existing document-level NMT methods are satisfied with a smattering sense of brief document-level information, while this work focuses on exploiting detailed document-level context in terms of multiple forms of document embeddings, which is capable of sufficiently modeling deeper and richer document-level context. The proposed document-aware NMT is implemented to enhance the Transformer baseline by introducing both global and local document-level clues on the source end. Experiments show that the proposed method significantly improves the translation performance over strong baselines and other related studies., Comment: arXiv admin note: substantial text overlap with arXiv:1910.14528

The data scarcity problem in emotion recognition from electroencephalography (EEG) leads to difficulty in building an affective model with high accuracy using machine learning algorithms or deep neural networks. Inspired by emerging deep generative models, we propose three methods for augmenting EEG training data to enhance the performance of emotion recognition models. Our proposed methods are based on two deep generative models, variational autoencoder (VAE) and generative adversarial network (GAN), and two data augmentation strategies. For the full usage strategy, all of the generated data are augmented to the training dataset without judging the quality of the generated data, while for partial usage, only high-quality data are selected and appended to the training dataset. These three methods are called conditional Wasserstein GAN (cWGAN), selective VAE (sVAE), and selective WGAN (sWGAN). To evaluate the effectiveness of these methods, we perform a systematic experimental study on two public EEG datasets for emotion recognition, namely, SEED and DEAP. We first generate realistic-like EEG training data in two forms: power spectral density and differential entropy. Then, we augment the original training datasets with a different number of generated realistic-like EEG data. Finally, we train support vector machines and deep neural networks with shortcut layers to build affective models using the original and augmented training datasets. The experimental results demonstrate that the augmented training datasets produced by our methods enhance the performance of EEG-based emotion recognition models and outperform the existing data augmentation methods such as conditional VAE, Gaussian noise, and rotational data augmentation.

A brain-computer interface (BCI) enables a user to communicate with a computer directly using brain signals. The most common non-invasive BCI modality, electroencephalogram (EEG), is sensitive to noise/artifact and suffers between-subject/within-subject non-stationarity. Therefore, it is difficult to build a generic pattern recognition model in an EEG-based BCI system that is optimal for different subjects, during different sessions, for different devices and tasks. Usually, a calibration session is needed to collect some training data for a new subject, which is time-consuming and user unfriendly. Transfer learning (TL), which utilizes data or knowledge from similar or relevant subjects/sessions/devices/tasks to facilitate learning for a new subject/session/device/task, is frequently used to reduce the amount of calibration effort. This paper reviews journal publications on TL approaches in EEG-based BCIs in the last few years, i.e., since 2016. Six paradigms and applications -- motor imagery, event-related potentials, steady-state visual evoked potentials, affective BCIs, regression problems, and adversarial attacks -- are considered. For each paradigm/application, we group the TL approaches into cross-subject/session, cross-device, and cross-task settings and review them separately. Observations and conclusions are made at the end of the paper, which may point to future research directions.

Compared with the rich studies on the motor brain-computer interface (BCI), the recently emerging affective BCI presents distinct challenges since the brain functional connectivity networks involving emotion are not well investigated. Previous studies on emotion recognition based on electroencephalography (EEG) signals mainly rely on single-channel-based feature extraction methods. In this paper, we propose a novel emotion-relevant critical subnetwork selection algorithm and investigate three EEG functional connectivity network features: strength, clustering coefficient, and eigenvector centrality. The discrimination ability of the EEG connectivity features in emotion recognition is evaluated on three public emotion EEG datasets: SEED, SEED-V, and DEAP. The strength feature achieves the best classification performance and outperforms the state-of-the-art differential entropy feature based on single-channel analysis. The experimental results reveal that distinct functional connectivity patterns are exhibited for the five emotions of disgust, fear, sadness, happiness, and neutrality. Furthermore, we construct a multimodal emotion recognition model by combining the functional connectivity features from EEG and the features from eye movements or physiological signals using deep canonical correlation analysis. The classification accuracies of multimodal emotion recognition are 95.08/6.42% on the SEED dataset, 84.51/5.11% on the SEED-V dataset, and 85.34/2.90% and 86.61/3.76% for arousal and valence on the DEAP dataset, respectively. The results demonstrate the complementary representation properties of the EEG connectivity features with eye movement data. In addition, we find that the brain networks constructed with 18 channels achieve comparable performance with that of the 62-channel network in multimodal emotion recognition and enable easier setups for BCI systems in real scenarios., Comment: 15 pages, 11 figures

Standard neural machine translation (NMT) is on the assumption that the document-level context is independent. Most existing document-level NMT approaches are satisfied with a smattering sense of global document-level information, while this work focuses on exploiting detailed document-level context in terms of a memory network. The capacity of the memory network that detecting the most relevant part of the current sentence from memory renders a natural solution to model the rich document-level context. In this work, the proposed document-aware memory network is implemented to enhance the Transformer NMT baseline. Experiments on several tasks show that the proposed method significantly improves the NMT performance over strong Transformer baselines and other related studies.

Multimodal signals are more powerful than unimodal data for emotion recognition since they can represent emotions more comprehensively. In this paper, we introduce deep canonical correlation analysis (DCCA) to multimodal emotion recognition. The basic idea behind DCCA is to transform each modality separately and coordinate different modalities into a hyperspace by using specified canonical correlation analysis constraints. We evaluate the performance of DCCA on five multimodal datasets: the SEED, SEED-IV, SEED-V, DEAP, and DREAMER datasets. Our experimental results demonstrate that DCCA achieves state-of-the-art recognition accuracy rates on all five datasets: 94.58% on the SEED dataset, 87.45% on the SEED-IV dataset, 84.33% and 85.62% for two binary classification tasks and 88.51% for a four-category classification task on the DEAP dataset, 83.08% on the SEED-V dataset, and 88.99%, 90.57%, and 90.67% for three binary classification tasks on the DREAMER dataset. We also compare the noise robustness of DCCA with that of existing methods when adding various amounts of noise to the SEED-V dataset. The experimental results indicate that DCCA has greater robustness. By visualizing feature distributions with t-SNE and calculating the mutual information between different modalities before and after using DCCA, we find that the features transformed by DCCA from different modalities are more homogeneous and discriminative across emotions.

Chemical reaction practicality is the core task among all symbol intelligence based chemical information processing, for example, it provides indispensable clue for further automatic synthesis route inference. Considering that chemical reactions have been represented in a language form, we propose a new solution to generally judge the practicality of organic reaction without considering complex quantum physical modeling or chemistry knowledge. While tackling the practicality judgment as a machine learning task from positive and negative (chemical reaction) samples, all existing studies have to carefully handle the serious insufficiency issue on the negative samples. We propose an auto-construction method to well solve the extensively existed long-term difficulty. Experimental results show our model can effectively predict the practicality of chemical reactions, which achieves a high accuracy of 99.76\% on real large-scale chemical lab reaction practicality judgment.

There are threefold challenges in emotion recognition. First, it is difficult to recognize human's emotional states only considering a single modality. Second, it is expensive to manually annotate the emotional data. Third, emotional data often suffers from missing modalities due to unforeseeable sensor malfunction or configuration issues. In this paper, we address all these problems under a novel multi-view deep generative framework. Specifically, we propose to model the statistical relationships of multi-modality emotional data using multiple modality-specific generative networks with a shared latent space. By imposing a Gaussian mixture assumption on the posterior approximation of the shared latent variables, our framework can learn the joint deep representation from multiple modalities and evaluate the importance of each modality simultaneously. To solve the labeled-data-scarcity problem, we extend our multi-view model to semi-supervised learning scenario by casting the semi-supervised classification problem as a specialized missing data imputation task. To address the missing-modality problem, we further extend our semi-supervised multi-view model to deal with incomplete data, where a missing view is treated as a latent variable and integrated out during inference. This way, the proposed overall framework can utilize all available (both labeled and unlabeled, as well as both complete and incomplete) data to improve its generalization ability. The experiments conducted on two real multi-modal emotion datasets demonstrated the superiority of our framework., Comment: arXiv admin note: text overlap with arXiv:1704.07548, 2018 ACM Multimedia Conference (MM'18)