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1. Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Author: Ceccato, Adrian, Forne, Carles, Bos, Lieuwe D., Camprubí-Rimblas, Marta, Areny-Balagueró, Aina, Campaña-Duel, Elena, Quero, Sara, Diaz, Emili, Roca, Oriol, De Gonzalo-Calvo, David, Fernández-Barat, Laia, Motos, Anna, Ferrer, Ricard, Riera, Jordi, Lorente, Jose A., Peñuelas, Oscar, Menendez, Rosario, Amaya-Villar, Rosario, Añón, José M., Balan-Mariño, Ana, Barberà, Carme, Barberán, José, Blandino-Ortiz, Aaron, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Estella, Ángel, Gallego, Elena, García-Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge-García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martin-Delgado, María Cruz, Martínez-Varela, Ignacio, Messa, Juan Lopez, Muñiz-Albaiceta, Guillermo, Nieto, María Teresa, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Pérez-García, Felipe, Ricart, Pilar, Roche-Campo, Ferran, Rodríguez, Alejandro, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho-Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo-Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, Bermejo, Jesus, Gonzalez, Jesica, Barbe, Ferran, Calfee, Carolyn S., Artigas, Antonio, and Torres, Antoni
Published: 2024
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2. Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients

Author: Galli, Flavia, Bindo, Francesco, Motos, Anna, Fernández-Barat, Laia, Barbeta, Enric, Gabarrús, Albert, Ceccato, Adrián, Bermejo-Martin, Jesús F., Ferrer, Ricard, Riera, Jordi, Peñuelas, Oscar, Lorente, José Ángel, de Gonzalo-Calvo, David, Menéndez, Rosario, Gonzalez, Jessica, Misuraca, Sofia, Palomeque, Andrea, Amaya-Villar, Rosario, Añón, José Manuel, Balan Mariño, Ana, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Carbajales Pérez, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raul, Franco, Nieves, Galbán, Cristóbal, Lopez Lago, Ana, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emilio, Estella, Ángel, Gallego Curto, Elena, García-Garmendia, José Luis, Gómez, José Manuel, Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martin Delgado, María Cruz, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, Lopez Messa, Juan, M. Albaiceta, Guillermo, Nieto, María Teresa, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Roche-Campo, Ferran, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, Boado, Maria Victoria, Rodríguez, Alejandro, Antonelli, Massimo, Blasi, Francesco, Barbé, Ferran, and Torres, Antoni
Published: 2023
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3. A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author: David de Gonzalo-Calvo, Marta Molinero, Iván D. Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C. García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Anna Moncusí-Moix, Ángel Estella, Luis Tamayo Lomas, Amalia Martínez de la Gándara, Lorenzo Socias, Yhivian Peñasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martínez Varela, María Cruz Martin Delgado, Pablo Vidal-Cortés, Juan López Messa, Felipe Pérez-García, Jesús Caballero, José M. Añón, Ana Loza-Vázquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemí Jorge García, Carmen Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Antoni Torres, and Ferran Barbé
Subjects: Biomarker, COVID-19, ICU, microRNA, Prognosis, SARS-CoV-2, Diseases of the respiratory system, RC705-779
Abstract: Abstract Background The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. Methods This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group. Results Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR
Published: 2023
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4. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author: Ortega, Alicia, de la Fuente, Amanda, Almansa, Raquel, Postigo, Tamara, Jorge, Noelia, Tedim, Ana P, González-González, Laura, Sánchez Recio, Lara, Trapiello, Wysali, Berezo, José Ángel, Herrán-Monge, Rubén, Blanco, Jesús, Enríquez, Pedro, Martínez, Isidoro, Martín-Vicente, María, Muñoz-Gómez, María José, Más, Vicente, Vázquez, Mónica, Cano, Olga, Martínez de la Gándara, Amalia, Rodríguez, Covadonga, Andrade, Gloria, Renedo, Gloria, Bustamante-Munguira, Juan, Cicuendez Ávila, Ramón, Salgado-Villén, María, Berruguilla-Pérez, Enrique, Güell, Estel, Casadiego Monachello, Fernando Javier, Recuerda Núñez, María, Sánchez Calvo, Juan Manuel, Peñasco-Martín, Yhivian, García Unzueta, María Teresa, Ceccato, Adrián, Fernández-Barat, Laia, Bouza Vieiro, María Teresa, Moreno-Romero, Ana, Pérez Bastida, Leire, del Río-Carbajo, Lorena, Albalá Martínez, Noelia, Gómez, José Manuel, Blasco, María Luisa, Caballero, Jesús, Barberà, Carme, González, Jessica, Nieto, María Teresa, Nieto-del Olmo, Jorge, Prol-Silva, Estefanía, Canseco-Ribas, Joan, Eiros, Jose María, Bermejo-Martin, Jesús F, García-Mateo, Nadia, Motos, Anna, Resino, Salvador, Tamayo, Luis, Ryan Murua, Pablo, Bustamante-Munguira, Elena, Gallego Curto, Elena, Úbeda-Iglesias, Alejandro, de la Torre, María del Carmen, Estella, Ángel, Campos-Fernández, Sandra, Martínez Varela, Ignacio, Pérez-García, Felipe, Socias, Lorenzo, López Messa, Juan, Vidal-Cortés, Pablo, Sagredo Meneses, Víctor, González-Rivera, Milagros, Carbonell, Nieves, de Gonzalo-Calvo, David, Martín Delgado, María Cruz, Valdivia, Luis Jorge, Martín-López, Caridad, Jorge García, Ruth Noemí, Maseda, Emilio, Loza-Vázquez, Ana, Kelvin, David J, Barbé, Ferrán, and Torres, Antoni
Published: 2023
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5. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author: Cabello, María Aguilar, Alcaraz-Serrano, Victoria, Aldecoa, Cesar, Alegre, Cynthia, Calderón, Ángela Algaba, Álvarez, Sergio, Ruiz, Antonio Álvarez, Andrea, Ruth, Aparicio, Maria de Alba, Arrieta, Marta, Ayestarán, J. Ignacio, Badia, Joan Ramon, Badía, Mariona, Pravia, Orville Báez, Mariño, Ana Balan, Balsera, Begoña, Barbena, Laura, Barbeta, Enric, Bardi, Tommaso, Segade, Patricia Barral, Barroso, Marta, García, José Ángel Berezo, Bermejo, Jesus, Bigas, Judit, Blancas, Rafael, Cortés, María Luisa Blasco, Saera, María Bodi, Bofill, Neus, Vieiro, María Teresa Bouza, Bueno, Leticia, Bustamante-Munguira, Juan, Martínez, Cecilia del Busto, Hermoso, David Campi, Fernández, Sandra Campos, Cano, Iosune, Canseco, Joan, Fernández, Pablo Cardinal, García, Laura Carrión, Carvalho, Sulamita, Castellà, Manuel, Castellví, Andrea, Castro, Pedro, Centelles-Serrano, María José, Ávila, Ramon Cicuendez, Cillóniz, Catia, Clar, Luisa, Climent, Cristina, Codina, Jordi, Conde, Pamela, Contreras, Sofía, Parra, Raul de Frutos, Sánchez, Raul de Pablo, Mendoza, Diego De, Díaz, Yolanda, Vilas, María Digna Rivas, Moreno, Cristina Dólera, Dot, Irene, Giraudo, Pedro Enríquez, Arijón, Inés Esmorís, Monjo, Teresa Farre, Fernández, Javier, Ferrando, Carlos, Figueras, Albert, Espina, Lorena Forcelledo, Franquesa, Enric, Furro, Àngels, Gabarrus, Albert, Galbán, Cristóbal, García, Felipe, García, Beatriz, Prieto, Emilio García, Redruello, Carlos García, Sagastume, Amaia García, Castillo, Maria Luisa Gascón, Gomà, Gemma, Casal, Vanesa Gómez, Gómez, Silvia, Gonzalez, Carmen Gómez, Gordo, Federico, Gracia, Maria Pilar, Fernández, María José Gutierrez, Herraiz, Alba, Herrán-Monge, Rubén, Ibarz, Mercedes, Iglesias, Silvia, Janer, Maria Teresa, Jiménez, Gabriel, Díaz, Mar Juan, Kiarostami, Karsa, Álvarez, Juan I. Lazo, León, Miguel, López-Gavín, Alexandre, Guerrero, Desiree Macias, Herrera, Nuria Mamolar, Mendiluce, Rafael Mañez, Mantellini, Cecilia L., Naya, Gregorio Marco, Barcos, Iris Marco, Marcos, Pilar, Peis, Enrique Marmol, Cuadrado, Marta Martín, Delgado, María Cruz Martin, Vicente, Paula Martín, Martínez, María, Fernández, Carmen Eulalia Martínez, Juan, Maria Dolores Martínez, Palacios, Basilisa Martínez, Jimenez, Juan Fernando Masa, Masclans, Joan Ramon, Maseda, Emilio, Fernández, Eva María Menor, Banderas, Priscila Metora, Minguez, Olga, Miralbés, Mar, Monclou, Josman, Montejo-González, Juan Carlos, Montserrat, Neus, Aznar, María Mora, Morales, Dulce, Cano, Sara Guadalupe Moreno, Rodríguez, David Mosquera, Muñoz-Bermúdez, Rosana, Nicolás, José María, Bou, Ramon Nogue, Salinas, Rafaela Nogueras, Ocón, Marta, Ortega, Ana, Ossa, Sergio, Pagliarani, Pablo, Parrilla, Francisco, Pedregosa-Díaz, José, Bastida, Leire Pérez, Pérez, Purificación, Pérez-García, Felipe, Planelles, Gloria Pérez, Rubio, Eva Pérez, Laguna, David Pestaña, Prados, Javier, Pujol, Andrés, Coll, Núria Ramon, Sanchez-Giron, Gloria Renedo, Roche-Campo, Ferran, Rodriguez, Laura, Castro, Felipe Rodríguez de, Rodríguez, Silvia, Ruiz, Covadonga Rodríguez, Rubio, Jorge, López, Alberto Rubio, Ruiz-García, Ángela Leonor, Miralles, Miriam Ruiz, Murúa, Pablo Ryan, Paz, Eva Saborido, Degracia, Ana Salazar, Sanchez, Miguel, Sánchez, Ana, Chinesta, Susana Sancho, Santacoloma, Bitor, Sariñena, Maria Teresa, Pensado, Marta Segura, Serra, Lidia, Serra-Fortuny, Mireia, Lázaro, Ainhoa Serrano, Servià, Lluís, Soliva, Laura, Speziale, Carla, Tormos, Adrián, Torres, Mateu, Tranque-Liberal, Celia, Trefler, Sandra, Trujillano, Javier, Vaca, Rafaela, Val, Estela, Ruiz, Luis Valdivia, Vallverdú, Montserrat, Martin-Montalvo, Maria Van der Hofstadt, Adrio, Sabela Vara, Vázquez, Nil, Vengoechea, Javier, Vilà-Vilardel, Clara, Vilanova, Judit, Warrington, Tatiana Villada, Yang, Hua, Yang, Minlan, Zapatero, Ana, González, Jessica, de Batlle, Jordi, Benítez, Iván D., Torres, Gerard, Santisteve, Sally, Targa, Adriano D.S., Gort-Paniello, Clara, Moncusí-Moix, Anna, Aguilà, Maria, Seck, Fatty, Ceccato, Adrián, Ferrer, Ricard, Motos, Anna, Riera, Jordi, Fernández, Laia, Menéndez, Rosario, Lorente, José Ángel, Peñuelas, Oscar, Garcia-Gasulla, Dario, Peñasco, Yhivian, Ricart, Pilar, Abril Palomares, Elena, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Beteré, Belén, Pozo-Laderas, Juan Carlos, Solé-Violan, Jordi, Salvador-Adell, Inmaculada, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho-Montero, José, Gómez, José M., Blandino Ortiz, Aaron, Tamayo Lomas, Luis, Úbeda, Alejandro, Catalán-González, Mercedes, Sánchez-Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio-Sanguino, Víctor D., Bustamante-Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Rodríguez, Covadonga, Castellanos-Ortega, Álvaro, Trenado, Josep, Marin-Corral, Judith, Albaiceta, Guillermo M., de la Torre, Maria del Carmen, Loza-Vázquez, Ana, Vidal, Pablo, Añón, Jose M., Carbajales Pérez, Cristina, Sagredo, Victor, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Angel, Diaz, Emili, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran
Published: 2023
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6. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Author: Torres, Antoni, Motos, Ana, Cillóniz, Catia, Ceccato, Adrián, Fernández-Barat, Laia, Gabarrús, Albert, Bermejo-Martin, Jesús, Ferrer, Ricard, Riera, Jordi, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Ángel, de Gonzalo-Calvo, David, Almansa, Raquel, Menéndez, Rosario, Palomeque, Andrea, Villar, Rosario Amaya, Añón, José M., Balan Mariño, Ana, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Carbajales Pérez, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raul, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Gómez, José M., Huerta, Arturo, García, Ruth Noemí Jorge, Loza-Vázquez, Ana, Marin-Corral, Judith, Martin Delgado, María Cruz, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, Albaiceta, Guillermo M., Nieto, Maite, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Victor, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Serra-Fortuny, Mireia, Socias, Lorenzo, Solé-Violan, Jordi, Suarez-Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, and Barbé, Ferran
Published: 2022
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7. Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units

Author: Torres, Antoni, Motos, Anna, Ceccato, Adrián, Bermejo-Martin, Jesús, de Gonzalo-Calvo, David, Pérez, Raquel, Barroso, Marta, Pascual, Ion Zubizarreta, Gonzalez, Jessica, Fernández-Barat, Laia, Ferrer, Ricard, Riera, Jordi, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Ángel, Almansa, Raquel, Menéndez, Rosario, Kiarostami, Kasra, Canseco, Joan, Villar, Rosario Amaya, Añón, José M., Mariño, Ana Balan, Barberà, Carme, Barberán, José, Ortiz, Aaron Blandino, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Pérez, Cristina Carbajales, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raúl, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., Torre, María del Carmen de la, Díaz, Emili, Estella, Ángel, Gallego, Elena, Garmendia, José Luis García, Gómez, José M., Huerta, Arturo, García, Ruth Noemí Jorge, Loza-Vázquez, Ana, Marin-Corral, Judith, Delgado, María Cruz Martin, Gándara, Amalia Martínez de la, Varela, Ignacio Martínez, Messa, Juan López, Albaiceta, Guillermo M., Nieto, Maite, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Víctor, Sánchez-Miralles, Ángel, Chinesta, Susana Sancho, Serra-Fortuny, Mireia, Socias, Lorenzo, Solé-Violan, Jordi, Suárez-Sipmann, Fernando, Lomas, Luis Tamayo, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, and Barbé, Ferran
Published: 2022
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8. Use of noninvasive measurement of the indocyanine green plasma disappearance rate in patients with septic shock.

Author: Gutiérrez-Morales, Isabel, Loza-Vázquez, Ana, Sánchez-Román†, José Antonio, Grilo-Reina, Antonio, and Navarro-Puerto, María Asunción
Subjects: INDOCYANINE green, SEPTIC shock, CRITICAL care medicine, SEPSIS, SHOCK (Pathology)
Abstract: Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2024
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9. Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study

Author: Gerard Moreno, Raquel Carbonell, Ignacio Martin-Loeches, Jordi Solé-Violán, Eudald Correig i Fraga, Josep Gómez, Manuel Ruiz-Botella, Sandra Trefler, María Bodí, Josefa Murcia Paya, Emili Díaz, Pablo Vidal-Cortes, Elisabeth Papiol, Antonio Albaya Moreno, Susana Sancho Chinesta, Lorenzo Socias Crespi, María del Carmen Lorente, Ana Loza Vázquez, Rebeca Vara Arlanzon, María Teresa Recio, Juan Carlos Ballesteros, Ricard Ferrer, Elisabeth Fernandez Rey, Marcos I. Restrepo, Ángel Estella, Antonio Margarit Ribas, Neus Guasch, Luis F. Reyes, Judith Marín-Corral, Alejandro Rodríguez, and the COVID-19 SEMICYUC Working Group
Subjects: Corticosteroids, COVID-19-associated acute respiratory distress syndrome, Intensive care unit, Mortality, Invasive mechanical ventilation, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Some unanswered questions persist regarding the effectiveness of corticosteroids for severe coronavirus disease 2019 (COVID-19) patients. We aimed to assess the clinical effect of corticosteroids on intensive care unit (ICU) mortality among mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients. Methods This was a retrospective study of prospectively collected data conducted in 70 ICUs (68 Spanish, one Andorran, one Irish), including mechanically ventilated COVID-19-associated ARDS patients admitted between February 6 and September 20, 2020. Individuals who received corticosteroids for refractory shock were excluded. Patients exposed to corticosteroids at admission were matched with patients without corticosteroids through propensity score matching. Primary outcome was all-cause ICU mortality. Secondary outcomes were to compare in-hospital mortality, ventilator-free days at 28 days, respiratory superinfection and length of stay between patients with corticosteroids and those without corticosteroids. We performed survival analysis accounting for competing risks and subgroup sensitivity analysis. Results We included 1835 mechanically ventilated COVID-19-associated ARDS, of whom 1117 (60.9%) received corticosteroids. After propensity score matching, ICU mortality did not differ between patients treated with corticosteroids and untreated patients (33.8% vs. 30.9%; p = 0.28). In survival analysis, corticosteroid treatment at ICU admission was associated with short-term survival benefit (HR 0.53; 95% CI 0.39–0.72), although beyond the 17th day of admission, this effect switched and there was an increased ICU mortality (long-term HR 1.68; 95% CI 1.16–2.45). The sensitivity analysis reinforced the results. Subgroups of age
Published: 2021
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10. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author: Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, and CIBERESUCICOVID Project (COV20/00110, ISCIII)
Subjects: Ventilatory ratio, Mechanical ventilation, COVID-19, SARS-CoV-2, Coronavirus, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0–171.2] to 180.0 [135.4–227.9] mmHg and the ventilatory ratio from 1.73 [1.33–2.25] to 1.96 [1.61–2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01–1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01–1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93–1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.
Published: 2021
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11. Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial

Author: Chochrad, Didier, Dive, Alain, Foret, Frédéric, Simon, Marc, Spapen, Herbert, Creteur, Jacques, Bouckaert, Yves, Biston, Patrick, Bourgeois, Marc, Novacek, Martin, Vymazal, Tomas, Svoboda, Petr, Pachl, Jan, Sramek, Vladimir, Hanauer, Michal, Hruby, Tomas, Balik, Martin, Suchy, Tomas, Lepape, Alain, Argaud, Laurent, Dailler, Frédéric, Desachy, Arnaud, Guitton, Christophe, Mercat, Alain, Meziani, Ferhat, Navellou, Jean-Christophe, Robert, Rene, Souweine, Bertrand, Tadie, Jean-Marc, Maamar, Adel, Annane, Djillali, Tamion, Fabienne, Gros, Antoine, Nseir, Saad, Schwebel, Carole, Francony, Gilles, Lefrant, Jean-Yves, Schneider, Francis, Gründling, Matthias, Motsch, Johann, Reill, Lorenz, Rolfes, Caroline, Welte, Tobias, Cornely, Oliver, Bloos, Frank, Deja, Maria, Schmidt, Katrin, Wappler, Frank, Meier-Hellmann, Andreas, Komnos, Apostolos, Bekos, Vasileios, Koulouras, Vasilios, Soultati, Ioanna, Baltopoulos, Georgios, Filntisis, Georgios, Zakynthinos, Epaminondas, Zakynthinos, Spyros, Pnevmatikos, Ioannis, Krémer, Ildikó, Szentkereszty, Zoltán, Sarkany, Agnes, Marjanek, Zsuzsa, Moura, Pedro, Pintado Delgado, Maria Consuelo, Montejo González, Juan Carlos, Ramirez, Paula, Torres Marti, Antonio, Valia, Juan Carlos, Lorente, Jose, Loza Vazquez, Ana, De Pablo Sanchez, Raúl, Escudero, Dolores, Ferrer Roca, Ricard, Pagani, Jean-Luc, Maggiorini, Marco, François, Bruno, Jafri, Hasan S, Chastre, Jean, Sánchez-García, Miguel, Eggimann, Philippe, Dequin, Pierre-François, Huberlant, Vincent, Viña Soria, Lucia, Boulain, Thierry, Bretonnière, Cédric, Pugin, Jérôme, Trenado, Josep, Hernandez Padilla, Ana Catalina, Ali, Omar, Shoemaker, Kathryn, Ren, Pin, Coenjaerts, Frank E, Ruzin, Alexey, Barraud, Olivier, Timbermont, Leen, Lammens, Christine, Pierre, Vadryn, Wu, Yuling, Vignaud, Julie, Colbert, Susan, Bellamy, Terramika, Esser, Mark T, Dubovsky, Filip, Bonten, Marc J, Goossens, Herman, and Laterre, Pierre-François
Published: 2021
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12. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author: Iván D. Benítez, Jordi de Batlle, Gerard Torres, Jessica González, David de Gonzalo-Calvo, Adriano D.S. Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Anna Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Yhivian Peñasco, Pilar Ricart, María Cruz Martin Delgado, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Fernando Suarez-Sipmann, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Maite Nieto, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, Jose Luis García-Garmendia, José M. Gómez, José Ángel Lorente, Aaron Blandino Ortiz, Luis Tamayo Lomas, Esther López-Ramos, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D. Gumucio-Sanguino, Arturo Huerta Garcia, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Amalia Martínez de la Gándara, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Juan Lopez Messa, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Neus Bofill, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Manuel Valledor Mendez, Emili Diaz, Ana López Lago, Antoni Torres, and Ferran Barbé
Subjects: COVID-19, Critical Care, Prognosis, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae. Methods: Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months. Findings: Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p
Published: 2022
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13. Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author: Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran
Published: 2021
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14. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author: Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran
Published: 2021
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15. Actores locales, impactos globales: aportes académicos en paradiplomacia

Author: Daniel Villarruel Reynoso, Ray Freddy Lara Pacheco, Carlos Iván Moreno Arellano, Miguel Ángel Sigala Gómez, Martha Guadalupe Loza Vázquez, Stéphanie Allard, Daniel Villarruel Reynoso, Betsy Karenina Rua Rodríguez, Ana Paula Morales Pérez, Leonardo Díaz Abraham, Carlos Nahuel Oddone, Mariano Álvarez
Published: 2020

16. A blood-based microRNA signature for the early prediction of the respiratory sequelae in critical COVID-19

Author: Molinero García, Marta, primary, Benítez, Ivan D, additional, Perez-Pons, Manel, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C, additional, Belmonte, Thalía, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez De La Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, De La Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martín Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesús, additional, Añón, Jose M, additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marín-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carme, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer Roca, Ricardo, additional, García-Gasulla, Darío, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Óscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F, additional, Torres, Antoni, additional, and Barbe Illa, Ferran-Eduard, additional
Published: 2023
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17. A plasma microRNA panel strengthens the early prediction of ICU mortality: A multicenter COVID-19 study

Author: Perez-Pons, Manel, primary, Benítez, Ivan D, additional, Molinero, Marta, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C., additional, Belmonte, Thalía, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez De La Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, De La Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martín Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesus, additional, Añón, José M., additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marin-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carmen, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Torres, Antoni, additional, Barbé, Ferran, additional, and De Gonzalo-Calvo, David, additional
Published: 2023
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18. Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author: Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, and CIBERESUCICOVID Project (COV20/00110, ISCIII)
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published: 2021
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19. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author: Jessica González, Jordi de Batlle, Iván D. Benítez, Gerard Torres, Sally Santisteve, Adriano D.S. Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Maria Aguilà, Fatty Seck, Adrián Ceccato, Ricard Ferrer, Anna Motos, Jordi Riera, Laia Fernández, Rosario Menéndez, José Ángel Lorente, Oscar Peñuelas, Dario Garcia-Gasulla, Yhivian Peñasco, Pilar Ricart, Elena Abril Palomares, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Belén Beteré, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Inmaculada Salvador-Adell, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, José M. Gómez, Aaron Blandino Ortiz, Luis Tamayo Lomas, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D. Gumucio-Sanguino, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Covadonga Rodríguez, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M. Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Emili Diaz, David de Gonzalo-Calvo, Antoni Torres, Ferran Barbé, María Aguilar Cabello, Victoria Alcaraz-Serrano, Cesar Aldecoa, Cynthia Alegre, Ángela Algaba Calderón, Sergio Álvarez, Antonio Álvarez Ruiz, Ruth Andrea, Maria de Alba Aparicio, Marta Arrieta, J. Ignacio Ayestarán, Joan Ramon Badia, Mariona Badía, Orville Báez Pravia, Ana Balan Mariño, Begoña Balsera, Laura Barbena, Enric Barbeta, Tommaso Bardi, Patricia Barral Segade, Marta Barroso, José Ángel Berezo García, Jesus Bermejo, Judit Bigas, Rafael Blancas, María Luisa Blasco Cortés, María Bodi Saera, Neus Bofill, María Teresa Bouza Vieiro, Leticia Bueno, Juan Bustamante-Munguira, Cecilia del Busto Martínez, David Campi Hermoso, Sandra Campos Fernández, Iosune Cano, Joan Canseco, Pablo Cardinal Fernández, Laura Carrión García, Sulamita Carvalho, Manuel Castellà, Andrea Castellví, Pedro Castro, María José Centelles-Serrano, Ramon Cicuendez Ávila, Catia Cillóniz, Luisa Clar, Cristina Climent, Jordi Codina, Pamela Conde, Sofía Contreras, Raul de Frutos Parra, Raul de Pablo Sánchez, Diego De Mendoza, Yolanda Díaz, María Digna Rivas Vilas, Cristina Dólera Moreno, Irene Dot, Pedro Enríquez Giraudo, Inés Esmorís Arijón, Teresa Farre Monjo, Javier Fernández, Carlos Ferrando, Albert Figueras, Lorena Forcelledo Espina, Enric Franquesa, Àngels Furro, Albert Gabarrus, Cristóbal Galbán, Felipe García, Beatriz García, Emilio García Prieto, Carlos García Redruello, Amaia García Sagastume, Maria Luisa Gascón Castillo, Gemma Gomà, Vanesa Gómez Casal, Silvia Gómez, Carmen Gómez Gonzalez, Federico Gordo, Maria Pilar Gracia, María José Gutierrez Fernández, Alba Herraiz, Rubén Herrán-Monge, Mercedes Ibarz, Silvia Iglesias, Maria Teresa Janer, Gabriel Jiménez, Mar Juan Díaz, Karsa Kiarostami, Juan I. Lazo Álvarez, Miguel León, Alexandre López-Gavín, Desiree Macias Guerrero, Nuria Mamolar Herrera, Rafael Mañez Mendiluce, Cecilia L. Mantellini, Gregorio Marco Naya, Iris Marco Barcos, Pilar Marcos, Enrique Marmol Peis, Marta Martín Cuadrado, María Cruz Martin Delgado, Paula Martín Vicente, María Martínez, Carmen Eulalia Martínez Fernández, Maria Dolores Martínez Juan, Basilisa Martínez Palacios, Juan Fernando Masa Jimenez, Joan Ramon Masclans, Emilio Maseda, Eva María Menor Fernández, Priscila Metora Banderas, Olga Minguez, Mar Miralbés, Josman Monclou, Juan Carlos Montejo-González, Neus Montserrat, María Mora Aznar, Dulce Morales, Sara Guadalupe Moreno Cano, David Mosquera Rodríguez, Rosana Muñoz-Bermúdez, José María Nicolás, Ramon Nogue Bou, Rafaela Nogueras Salinas, Marta Ocón, Ana Ortega, Sergio Ossa, Pablo Pagliarani, Francisco Parrilla, José Pedregosa-Díaz, Leire Pérez Bastida, Purificación Pérez, Felipe Pérez-García, Gloria Pérez Planelles, Eva Pérez Rubio, David Pestaña Laguna, Javier Prados, Andrés Pujol, Núria Ramon Coll, Gloria Renedo Sanchez-Giron, Ferran Roche-Campo, Laura Rodriguez, Felipe Rodríguez de Castro, Silvia Rodríguez, Covadonga Rodríguez Ruiz, Jorge Rubio, Alberto Rubio López, Ángela Leonor Ruiz-García, Miriam Ruiz Miralles, Pablo Ryan Murúa, Eva Saborido Paz, Ana Salazar Degracia, Miguel Sanchez, Ana Sánchez, Susana Sancho Chinesta, Bitor Santacoloma, Maria Teresa Sariñena, Marta Segura Pensado, Lidia Serra, Mireia Serra-Fortuny, Ainhoa Serrano Lázaro, Lluís Servià, Laura Soliva, Carla Speziale, Adrián Tormos, Mateu Torres, Celia Tranque-Liberal, Sandra Trefler, Javier Trujillano, Rafaela Vaca, Estela Val, Luis Valdivia Ruiz, Montserrat Vallverdú, Maria Van der Hofstadt Martin-Montalvo, Sabela Vara Adrio, Nil Vázquez, Javier Vengoechea, Clara Vilà-Vilardel, Judit Vilanova, Tatiana Villada Warrington, Hua Yang, Minlan Yang, and Ana Zapatero
Subjects: Pulmonary and Respiratory Medicine
Published: 2023

20. A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author: de Gonzalo-Calvo, David, primary, Molinero, Marta, additional, Benítez, Iván D., additional, Perez-Pons, Manel, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C., additional, Belmonte, Thalia, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez de la Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, de la Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martin Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesús, additional, Añón, José M., additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marin-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carmen, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Torres, Antoni, additional, and Barbé, Ferran, additional
Published: 2023
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21. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author: Bermejo-Martin, Jesús F, primary, García-Mateo, Nadia, additional, Motos, Anna, additional, Resino, Salvador, additional, Tamayo, Luis, additional, Ryan Murua, Pablo, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Úbeda-Iglesias, Alejandro, additional, de la Torre, María del Carmen, additional, Estella, Ángel, additional, Campos-Fernández, Sandra, additional, Martínez Varela, Ignacio, additional, Pérez-García, Felipe, additional, Socias, Lorenzo, additional, López Messa, Juan, additional, Vidal-Cortés, Pablo, additional, Sagredo Meneses, Víctor, additional, González-Rivera, Milagros, additional, Carbonell, Nieves, additional, de Gonzalo-Calvo, David, additional, Martín Delgado, María Cruz, additional, Valdivia, Luis Jorge, additional, Martín-López, Caridad, additional, Jorge García, Ruth Noemí, additional, Maseda, Emilio, additional, Loza-Vázquez, Ana, additional, Kelvin, David J, additional, Barbé, Ferrán, additional, Torres, Antoni, additional, Ortega, Alicia, additional, de la Fuente, Amanda, additional, Almansa, Raquel, additional, Postigo, Tamara, additional, Jorge, Noelia, additional, Tedim, Ana P, additional, González-González, Laura, additional, Sánchez Recio, Lara, additional, Trapiello, Wysali, additional, Berezo, José Ángel, additional, Herrán-Monge, Rubén, additional, Blanco, Jesús, additional, Enríquez, Pedro, additional, Martínez, Isidoro, additional, Martín-Vicente, María, additional, Muñoz-Gómez, María José, additional, Más, Vicente, additional, Vázquez, Mónica, additional, Cano, Olga, additional, Martínez de la Gándara, Amalia, additional, Rodríguez, Covadonga, additional, Andrade, Gloria, additional, Renedo, Gloria, additional, Bustamante-Munguira, Juan, additional, Cicuendez Ávila, Ramón, additional, Salgado-Villén, María, additional, Berruguilla-Pérez, Enrique, additional, Güell, Estel, additional, Casadiego Monachello, Fernando Javier, additional, Recuerda Núñez, María, additional, Sánchez Calvo, Juan Manuel, additional, Peñasco-Martín, Yhivian, additional, García Unzueta, María Teresa, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Bouza Vieiro, María Teresa, additional, Moreno-Romero, Ana, additional, Pérez Bastida, Leire, additional, del Río-Carbajo, Lorena, additional, Albalá Martínez, Noelia, additional, Gómez, José Manuel, additional, Blasco, María Luisa, additional, Caballero, Jesús, additional, Barberà, Carme, additional, González, Jessica, additional, Nieto, María Teresa, additional, Nieto-del Olmo, Jorge, additional, Prol-Silva, Estefanía, additional, Canseco-Ribas, Joan, additional, and Eiros, Jose María, additional
Published: 2023
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22. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author: Cillóniz, Catia, primary, Motos, Anna, additional, Castañeda, Tatiana, additional, Gabarrús, Albert, additional, Barbé, Ferran, additional, Torres, Antoni, additional, Gumucio-Sanguino, Víctor D., additional, Mañez, Rafael, additional, Solé-Violan, Jordi, additional, de Castro, Felipe Rodríguez, additional, Suarez-Sipmann, Fernando, additional, García, Ruth Noemí Jorge, additional, Aznar, María Mora, additional, Torres, Mateu, additional, Martinez, María, additional, Alegre, Cynthia, additional, Riera, Jordi, additional, Contreras, Sofía, additional, Pericas, Juan Manuel, additional, Ferrer, Ricard, additional, Caballero, Jesús, additional, Trujillano, Javier, additional, Vallverdú, Montse, additional, León, Miguel, additional, Badía, Mariona, additional, Balsera, Begoña, additional, Servià, Lluís, additional, Vilanova, Judit, additional, Rodríguez, Silvia, additional, Montserrat, Neus, additional, Iglesias, Silvia, additional, Prados, Javier, additional, Carvalho, Sula, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Jiménez, Gabriel, additional, Codina, Jordi, additional, Val, Estela, additional, Pagliarani, Pablo, additional, Rubio, Jorge, additional, Morales, Dulce, additional, Pujol, Andrés, additional, Furro, Àngels, additional, García, Beatriz, additional, Torres, Gerard, additional, Vengoechea, Javier, additional, Gonzalo-Calvo, David de, additional, González, Jessica, additional, Gomez, Silvia, additional, Gómez, José M., additional, Franco, Nieves, additional, Barberán, José, additional, Albaiceta, Guillermo M, additional, Espina, Lorena Forcelledo, additional, Prieto, Emilio García, additional, Vicente, Paula Martín, additional, del Busto Martínez, Cecilia, additional, Vidal-Cortés, Pablo, additional, Garmendia, José Luis García, additional, Cabello, María Aguilar, additional, Fernández, Carmen Eulalia Martínez, additional, Carbonell, Nieves, additional, Cortés, María Luisa Blasco, additional, Lázaro, Ainhoa Serrano, additional, Díaz, Mar Juan, additional, Ortiz, Aaron Blandino, additional, Menendez, Rosario, additional, Valdivia, Luis Jorge, additional, Boado, María Victoria, additional, Chinesta, Susana Sancho, additional, del Carmen de la Torre, Maria, additional, Varela, Ignacio Martínez, additional, Vieiro, María Teresa Bouza, additional, Arijón, Inés Esmorís, additional, Hermoso, David Campi, additional, Salinas, Rafaela Nogueras, additional, Monjo, Teresa Farre, additional, Bou, Ramon Nogue, additional, Naya, Gregorio Marco, additional, Barberà, Carme, additional, Coll, Núria Ramon, additional, Catalán-González, Mercedes, additional, Montejo-González, Juan Carlos, additional, Sanchez-Giron, Gloria Renedo, additional, Bustamante-Munguira, Juan, additional, Bustamante-Munguira, Elena, additional, Avila, Ramon Cicuendez, additional, Herrera, Nuria Mamolar, additional, Almansa, Raquel, additional, Ortega, Alicia, additional, Bermejo-Martin, Jesús, additional, Sagredo, Víctor, additional, Añon, Jose, additional, Agrifoglio, Alexander, additional, Cachafeiro, Lucia, additional, Maseda, Emilio, additional, Socias, Lorenzo, additional, Novo, Mariana Andrea, additional, Figueras, Albert, additional, Janer, Maria Teresa, additional, Soliva, Laura, additional, Ocón, Marta, additional, Clar, Luisa, additional, Ayestarán, J Ignacio, additional, Peñasco, Yhivian, additional, Fernández, Sandra Campos, additional, Serra-Fortuny, Mireia, additional, Forcadell-Ferreres, Eva, additional, Salvador-Adell, Immaculada, additional, Bofill, Neus, additional, Adell-Serrano, Berta, additional, Díaz, Josep Pedregosa, additional, Casacuberta-Barberà, Núria, additional, Urrelo-Cerrón, Luis, additional, Piñol-Tena, Àngels, additional, Roche-Campo, Ferran, additional, de la Gándara, Amalia Martínez, additional, Murúa, Pablo Ryan, additional, Ruíz, Covadonga Rodríguez, additional, García, Laura Carrión, additional, Álvarez, Juan I Lazo, additional, Lorente, José Ángel, additional, Loza-Vázquez, Ana, additional, Guerrero, Desire Macias, additional, Huerta, Arturo, additional, Tognetti, Daniel, additional, Redruello, Carlos García, additional, Rodríguez, David Mosquera, additional, Fernández, Eva María Menor, additional, Adrio, Sabela Vara, additional, Casal, Vanesa Gómez, additional, Pensado, Marta Segura, additional, Vilas, María Digna Rivas, additional, Sagastume, Amaia García, additional, de Pablo Sánchez, Raul, additional, Laguna, David Pestaña, additional, Bardi, Tommaso, additional, Villar, Rosario Amaya, additional, Gonzalez, Carmen Gómez, additional, Castillo, Maria Luisa Gascón, additional, Garnacho-Montero, José, additional, Cantón-Bulnes, María Luisa, additional, Marin-Corral, Judith, additional, Pérez, Cristina Carbajales, additional, Masclans, Joan Ramon, additional, Degracia, Ana Salazar, additional, Bigas, Judit, additional, Muñoz-Bermúdez, Rosana, additional, Vilà-Vilardel, Clara, additional, Parrilla, Francisco, additional, Dot, Irene, additional, Zapatero, Ana, additional, Díaz, Yolanda, additional, Gracia, María Pilar, additional, Pérez, Purificación, additional, Castellví, Andrea, additional, Climent, Cristina, additional, Serra, Lidia, additional, Barbena, Laura, additional, Cano, Iosune, additional, Ricart, Pilar, additional, Herraiz, Alba, additional, Marcos, Pilar, additional, Rodríguez, Laura, additional, Sariñena, Maria Teresa, additional, Sánchez, Ana, additional, Úbeda, Alejandro, additional, Delgado, María Cruz Martin, additional, Gallego, Elena, additional, Jimenez, Juan Fernando Masa, additional, Gomà, Gemma, additional, Díaz, Emi, additional, Ibarz, Mercedes, additional, De Mendoza, Diego, additional, Barbeta, Enric, additional, Alcaraz-Serrano, Victoria, additional, Badia, Joan Ramon, additional, Castella, Manuel, additional, Bueno, Leticia, additional, Ceccato, Adrian, additional, Palomeque, Andrea, additional, Barat, Laia Fernandez, additional, Cillóniz, Catia, additional, Conde, Pamela, additional, Fernández, Javier, additional, Gabarrus, Albert, additional, Kiarostami, Karsa, additional, López-Gavín, Alexandre, additional, Mantellini, Cecilia L, additional, Speziale, Carla, additional, Vázquez, Nil, additional, Yang, Hua, additional, Yang, Minlan, additional, Ferrando, Carlos, additional, Castro, Pedro, additional, Arrieta, Marta, additional, Nicolas, Jose Maria, additional, Andrea, Rut, additional, Barroso, Marta, additional, Pérez, Raquel, additional, Álvarez, Sergio, additional, Garcia-Gasulla, Dario, additional, Tormos, Adrián, additional, Lomas, Luis Tamayo, additional, Aldecoa, Cesar, additional, Herrán-Monge, Rubén, additional, García, José Ángel Berezo, additional, Giraudo, Pedro Enríquez, additional, Fernández, Pablo Cardinal, additional, López, Alberto Rubio, additional, Pravia, Orville Báez, additional, Messa, Juan López, additional, Bastida, Leire Pérez, additional, Ruiz, Antonjo Alvarez, additional, Trenado, José, additional, Pous, Anna Parera, additional, Galbán, Cristóbal, additional, Lago, Ana López, additional, Paz, Eva Saborido, additional, Segade, Patricia Barral, additional, Mariño, Ana Balan, additional, Mendez, Manuel Valledor, additional, de Frutos, Raúl, additional, Aguilera, Luciano, additional, Pérez-García, Felipe, additional, López-Ramos, Esther, additional, Ruiz-García, Ángela Leonor, additional, Beteré, Belén, additional, Blancas, Rafael, additional, Dólera, Cristina, additional, Planelles, Gloria Perez, additional, Peis, Enrique Marmol, additional, Juan, Maria Dolores Martinez, additional, Miralles, Miriam Ruiz, additional, Rubio, Eva Perez, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Sánchez-Miralles, Ángel, additional, Warrington, Tatiana Villada, additional, Pozo-Laderas, Juan Carlos, additional, Estrella, Angel, additional, Cano, Sara Guadalupe Moreno, additional, Gordo, Federico, additional, Palacios, Basilisa Martinez, additional, Nieto, Maite, additional, Nieto, Maria Teresa, additional, Ossa, Sergio, additional, Ortega, Ana, additional, Sanchez, Miguel, additional, and Santacoloma, Bitor, additional
Published: 2023
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23. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author: Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan Murua, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Úbeda-Iglesias, María del Carmen de la Torre, Ángel Estella, Sandra Campos-Fernández, Ignacio Martínez Varela, Felipe Pérez-García, Lorenzo Socias, Juan López Messa, Pablo Vidal-Cortés, Víctor Sagredo Meneses, Milagros González-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, María Cruz Martín Delgado, Luis Jorge Valdivia, Caridad Martín-López, Ruth Noemí Jorge García, Emilio Maseda, Ana Loza-Vázquez, David J Kelvin, Ferrán Barbé, Antoni Torres, Alicia Ortega, Amanda de la Fuente, Raquel Almansa, Tamara Postigo, Noelia Jorge, Ana P Tedim, Laura González-González, Lara Sánchez Recio, Wysali Trapiello, José Ángel Berezo, Rubén Herrán-Monge, Jesús Blanco, Pedro Enríquez, Isidoro Martínez, María Martín-Vicente, María José Muñoz-Gómez, Vicente Más, Mónica Vázquez, Olga Cano, Amalia Martínez de la Gándara, Covadonga Rodríguez, Gloria Andrade, Gloria Renedo, Juan Bustamante-Munguira, Ramón Cicuendez Ávila, María Salgado-Villén, Enrique Berruguilla-Pérez, Estel Güell, Fernando Javier Casadiego Monachello, María Recuerda Núñez, Juan Manuel Sánchez Calvo, Yhivian Peñasco-Martín, María Teresa García Unzueta, Adrián Ceccato, Laia Fernández-Barat, María Teresa Bouza Vieiro, Ana Moreno-Romero, Leire Pérez Bastida, Lorena del Río-Carbajo, Noelia Albalá Martínez, José Manuel Gómez, María Luisa Blasco, Jesús Caballero, Carme Barberà, Jessica González, María Teresa Nieto, Jorge Nieto-del Olmo, Estefanía Prol-Silva, Joan Canseco-Ribas, Jose María Eiros, Instituto de Salud Carlos III, Canadian Institutes of Health Research, Li Ka Shing Foundation, European Society of Clinical Microbiology and Infectious Diseases, Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), and Unión Europea. Fondo Social Europeo (ESF/FSE)
Subjects: Microbiology (medical), Infectious Diseases, Spain, Virology, COVID-19, Microbiology
Abstract: Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p
Published: 2023

24. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author: González, Jessica, primary, de Batlle, Jordi, additional, Benítez, Iván D., additional, Torres, Gerard, additional, Santisteve, Sally, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Aguilà, Maria, additional, Seck, Fatty, additional, Ceccato, Adrián, additional, Ferrer, Ricard, additional, Motos, Anna, additional, Riera, Jordi, additional, Fernández, Laia, additional, Menéndez, Rosario, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Garcia-Gasulla, Dario, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Abril Palomares, Elena, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Beteré, Belén, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Salvador-Adell, Inmaculada, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Rodríguez, Covadonga, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M., additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Diaz, Emili, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Cabello, María Aguilar, additional, Alcaraz-Serrano, Victoria, additional, Aldecoa, Cesar, additional, Alegre, Cynthia, additional, Calderón, Ángela Algaba, additional, Álvarez, Sergio, additional, Ruiz, Antonio Álvarez, additional, Andrea, Ruth, additional, Aparicio, Maria de Alba, additional, Arrieta, Marta, additional, Ayestarán, J. Ignacio, additional, Badia, Joan Ramon, additional, Badía, Mariona, additional, Pravia, Orville Báez, additional, Mariño, Ana Balan, additional, Balsera, Begoña, additional, Barbena, Laura, additional, Barbeta, Enric, additional, Bardi, Tommaso, additional, Segade, Patricia Barral, additional, Barroso, Marta, additional, García, José Ángel Berezo, additional, Bermejo, Jesus, additional, Bigas, Judit, additional, Blancas, Rafael, additional, Cortés, María Luisa Blasco, additional, Saera, María Bodi, additional, Bofill, Neus, additional, Vieiro, María Teresa Bouza, additional, Bueno, Leticia, additional, Bustamante-Munguira, Juan, additional, Martínez, Cecilia del Busto, additional, Hermoso, David Campi, additional, Fernández, Sandra Campos, additional, Cano, Iosune, additional, Canseco, Joan, additional, Fernández, Pablo Cardinal, additional, García, Laura Carrión, additional, Carvalho, Sulamita, additional, Castellà, Manuel, additional, Castellví, Andrea, additional, Castro, Pedro, additional, Centelles-Serrano, María José, additional, Ávila, Ramon Cicuendez, additional, Cillóniz, Catia, additional, Clar, Luisa, additional, Climent, Cristina, additional, Codina, Jordi, additional, Conde, Pamela, additional, Contreras, Sofía, additional, Parra, Raul de Frutos, additional, Sánchez, Raul de Pablo, additional, Mendoza, Diego De, additional, Díaz, Yolanda, additional, Vilas, María Digna Rivas, additional, Moreno, Cristina Dólera, additional, Dot, Irene, additional, Giraudo, Pedro Enríquez, additional, Arijón, Inés Esmorís, additional, Monjo, Teresa Farre, additional, Fernández, Javier, additional, Ferrando, Carlos, additional, Figueras, Albert, additional, Espina, Lorena Forcelledo, additional, Franquesa, Enric, additional, Furro, Àngels, additional, Gabarrus, Albert, additional, Galbán, Cristóbal, additional, García, Felipe, additional, García, Beatriz, additional, Prieto, Emilio García, additional, Redruello, Carlos García, additional, Sagastume, Amaia García, additional, Castillo, Maria Luisa Gascón, additional, Gomà, Gemma, additional, Casal, Vanesa Gómez, additional, Gómez, Silvia, additional, Gonzalez, Carmen Gómez, additional, Gordo, Federico, additional, Gracia, Maria Pilar, additional, Fernández, María José Gutierrez, additional, Herraiz, Alba, additional, Herrán-Monge, Rubén, additional, Ibarz, Mercedes, additional, Iglesias, Silvia, additional, Janer, Maria Teresa, additional, Jiménez, Gabriel, additional, Díaz, Mar Juan, additional, Kiarostami, Karsa, additional, Álvarez, Juan I. Lazo, additional, León, Miguel, additional, López-Gavín, Alexandre, additional, Guerrero, Desiree Macias, additional, Herrera, Nuria Mamolar, additional, Mendiluce, Rafael Mañez, additional, Mantellini, Cecilia L., additional, Naya, Gregorio Marco, additional, Barcos, Iris Marco, additional, Marcos, Pilar, additional, Peis, Enrique Marmol, additional, Cuadrado, Marta Martín, additional, Delgado, María Cruz Martin, additional, Vicente, Paula Martín, additional, Martínez, María, additional, Fernández, Carmen Eulalia Martínez, additional, Juan, Maria Dolores Martínez, additional, Palacios, Basilisa Martínez, additional, Jimenez, Juan Fernando Masa, additional, Masclans, Joan Ramon, additional, Maseda, Emilio, additional, Fernández, Eva María Menor, additional, Banderas, Priscila Metora, additional, Minguez, Olga, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Montejo-González, Juan Carlos, additional, Montserrat, Neus, additional, Aznar, María Mora, additional, Morales, Dulce, additional, Cano, Sara Guadalupe Moreno, additional, Rodríguez, David Mosquera, additional, Muñoz-Bermúdez, Rosana, additional, Nicolás, José María, additional, Bou, Ramon Nogue, additional, Salinas, Rafaela Nogueras, additional, Ocón, Marta, additional, Ortega, Ana, additional, Ossa, Sergio, additional, Pagliarani, Pablo, additional, Parrilla, Francisco, additional, Pedregosa-Díaz, José, additional, Bastida, Leire Pérez, additional, Pérez, Purificación, additional, Pérez-García, Felipe, additional, Planelles, Gloria Pérez, additional, Rubio, Eva Pérez, additional, Laguna, David Pestaña, additional, Prados, Javier, additional, Pujol, Andrés, additional, Coll, Núria Ramon, additional, Sanchez-Giron, Gloria Renedo, additional, Roche-Campo, Ferran, additional, Rodriguez, Laura, additional, Castro, Felipe Rodríguez de, additional, Rodríguez, Silvia, additional, Ruiz, Covadonga Rodríguez, additional, Rubio, Jorge, additional, López, Alberto Rubio, additional, Ruiz-García, Ángela Leonor, additional, Miralles, Miriam Ruiz, additional, Murúa, Pablo Ryan, additional, Paz, Eva Saborido, additional, Degracia, Ana Salazar, additional, Sanchez, Miguel, additional, Sánchez, Ana, additional, Chinesta, Susana Sancho, additional, Santacoloma, Bitor, additional, Sariñena, Maria Teresa, additional, Pensado, Marta Segura, additional, Serra, Lidia, additional, Serra-Fortuny, Mireia, additional, Lázaro, Ainhoa Serrano, additional, Servià, Lluís, additional, Soliva, Laura, additional, Speziale, Carla, additional, Tormos, Adrián, additional, Torres, Mateu, additional, Tranque-Liberal, Celia, additional, Trefler, Sandra, additional, Trujillano, Javier, additional, Vaca, Rafaela, additional, Val, Estela, additional, Ruiz, Luis Valdivia, additional, Vallverdú, Montserrat, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Adrio, Sabela Vara, additional, Vázquez, Nil, additional, Vengoechea, Javier, additional, Vilà-Vilardel, Clara, additional, Vilanova, Judit, additional, Warrington, Tatiana Villada, additional, Yang, Hua, additional, Yang, Minlan, additional, and Zapatero, Ana, additional
Published: 2023
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25. Additional file 2 of A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author: de Gonzalo-Calvo, David, Molinero, Marta, Benítez, Iván D., Perez-Pons, Manel, García-Mateo, Nadia, Ortega, Alicia, Postigo, Tamara, García-Hidalgo, María C., Belmonte, Thalia, Rodríguez-Muñoz, Carlos, González, Jessica, Torres, Gerard, Gort-Paniello, Clara, Moncusí-Moix, Anna, Estella, Ángel, Tamayo Lomas, Luis, Martínez de la Gándara, Amalia, Socias, Lorenzo, Peñasco, Yhivian, de la Torre, Maria Del Carmen, Bustamante-Munguira, Elena, Gallego Curto, Elena, Martínez Varela, Ignacio, Martin Delgado, María Cruz, Vidal-Cortés, Pablo, López Messa, Juan, Pérez-García, Felipe, Caballero, Jesús, Añón, José M., Loza-Vázquez, Ana, Carbonell, Nieves, Marin-Corral, Judith, Jorge García, Ruth Noemí, Barberà, Carmen, Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Lorente-Balanza, Jose Ángel, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Bermejo-Martin, Jesús F., Torres, Antoni, and Barbé, Ferran
Abstract: Supplementary Material 2
Published: 2023
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26. Additional file 1 of A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author: de Gonzalo-Calvo, David, Molinero, Marta, Benítez, Iván D., Perez-Pons, Manel, García-Mateo, Nadia, Ortega, Alicia, Postigo, Tamara, García-Hidalgo, María C., Belmonte, Thalia, Rodríguez-Muñoz, Carlos, González, Jessica, Torres, Gerard, Gort-Paniello, Clara, Moncusí-Moix, Anna, Estella, Ángel, Tamayo Lomas, Luis, Martínez de la Gándara, Amalia, Socias, Lorenzo, Peñasco, Yhivian, de la Torre, Maria Del Carmen, Bustamante-Munguira, Elena, Gallego Curto, Elena, Martínez Varela, Ignacio, Martin Delgado, María Cruz, Vidal-Cortés, Pablo, López Messa, Juan, Pérez-García, Felipe, Caballero, Jesús, Añón, José M., Loza-Vázquez, Ana, Carbonell, Nieves, Marin-Corral, Judith, Jorge García, Ruth Noemí, Barberà, Carmen, Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Lorente-Balanza, Jose Ángel, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Bermejo-Martin, Jesús F., Torres, Antoni, and Barbé, Ferran
Abstract: Supplementary Material 1
Published: 2023
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27. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author: Catia Cillóniz, Anna Motos, Tatiana Castañeda, Albert Gabarrús, Ferran Barbé, Antoni Torres, Víctor D. Gumucio-Sanguino, Rafael Mañez, Jordi Solé-Violan, Felipe Rodríguez de Castro, Fernando Suarez-Sipmann, Ruth Noemí Jorge García, María Mora Aznar, Mateu Torres, María Martinez, Cynthia Alegre, Jordi Riera, Sofía Contreras, Juan Manuel Pericas, Ricard Ferrer, Jesús Caballero, Javier Trujillano, Montse Vallverdú, Miguel León, Mariona Badía, Begoña Balsera, Lluís Servià, Judit Vilanova, Silvia Rodríguez, Neus Montserrat, Silvia Iglesias, Javier Prados, Sula Carvalho, Mar Miralbés, Josman Monclou, Gabriel Jiménez, Jordi Codina, Estela Val, Pablo Pagliarani, Jorge Rubio, Dulce Morales, Andrés Pujol, Àngels Furro, Beatriz García, Gerard Torres, Javier Vengoechea, David de Gonzalo-Calvo, Jessica González, Silvia Gomez, José M. Gómez, Nieves Franco, José Barberán, Guillermo M Albaiceta, Lorena Forcelledo Espina, Emilio García Prieto, Paula Martín Vicente, Cecilia del Busto Martínez, Pablo Vidal-Cortés, José Luis García Garmendia, María Aguilar Cabello, Carmen Eulalia Martínez Fernández, Nieves Carbonell, María Luisa Blasco Cortés, Ainhoa Serrano Lázaro, Mar Juan Díaz, Aaron Blandino Ortiz, Rosario Menendez, Luis Jorge Valdivia, María Victoria Boado, Susana Sancho Chinesta, Maria del Carmen de la Torre, Ignacio Martínez Varela, María Teresa Bouza Vieiro, Inés Esmorís Arijón, David Campi Hermoso, Rafaela Nogueras Salinas, Teresa Farre Monjo, Ramon Nogue Bou, Gregorio Marco Naya, Carme Barberà, Núria Ramon Coll, Mercedes Catalán-González, Juan Carlos Montejo-González, Gloria Renedo Sanchez-Giron, Juan Bustamante-Munguira, Elena Bustamante-Munguira, Ramon Cicuendez Avila, Nuria Mamolar Herrera, Raquel Almansa, Alicia Ortega, Jesús Bermejo-Martin, Víctor Sagredo, Jose Añon, Alexander Agrifoglio, Lucia Cachafeiro, Emilio Maseda, Lorenzo Socias, Mariana Andrea Novo, Albert Figueras, Maria Teresa Janer, Laura Soliva, Marta Ocón, Luisa Clar, J Ignacio Ayestarán, Yhivian Peñasco, Sandra Campos Fernández, Mireia Serra-Fortuny, Eva Forcadell-Ferreres, Immaculada Salvador-Adell, Neus Bofill, Berta Adell-Serrano, Josep Pedregosa Díaz, Núria Casacuberta-Barberà, Luis Urrelo-Cerrón, Àngels Piñol-Tena, Ferran Roche-Campo, Amalia Martínez de la Gándara, Pablo Ryan Murúa, Covadonga Rodríguez Ruíz, Laura Carrión García, Juan I Lazo Álvarez, José Ángel Lorente, Ana Loza-Vázquez, Desire Macias Guerrero, Arturo Huerta, Daniel Tognetti, Carlos García Redruello, David Mosquera Rodríguez, Eva María Menor Fernández, Sabela Vara Adrio, Vanesa Gómez Casal, Marta Segura Pensado, María Digna Rivas Vilas, Amaia García Sagastume, Raul de Pablo Sánchez, David Pestaña Laguna, Tommaso Bardi, Rosario Amaya Villar, Carmen Gómez Gonzalez, Maria Luisa Gascón Castillo, José Garnacho-Montero, María Luisa Cantón-Bulnes, Judith Marin-Corral, Cristina Carbajales Pérez, Joan Ramon Masclans, Ana Salazar Degracia, Judit Bigas, Rosana Muñoz-Bermúdez, Clara Vilà-Vilardel, Francisco Parrilla, Irene Dot, Ana Zapatero, Yolanda Díaz, María Pilar Gracia, Purificación Pérez, Andrea Castellví, Cristina Climent, Lidia Serra, Laura Barbena, Iosune Cano, Pilar Ricart, Alba Herraiz, Pilar Marcos, Laura Rodríguez, Maria Teresa Sariñena, Ana Sánchez, Alejandro Úbeda, María Cruz Martin Delgado, Elena Gallego, Juan Fernando Masa Jimenez, Gemma Gomà, Emi Díaz, Mercedes Ibarz, Diego De Mendoza, Enric Barbeta, Victoria Alcaraz-Serrano, Joan Ramon Badia, Manuel Castella, Leticia Bueno, Adrian Ceccato, Andrea Palomeque, Laia Fernandez Barat, Pamela Conde, Javier Fernández, Albert Gabarrus, Karsa Kiarostami, Alexandre López-Gavín, Cecilia L Mantellini, Carla Speziale, Nil Vázquez, Hua Yang, Minlan Yang, Carlos Ferrando, Pedro Castro, Marta Arrieta, Jose Maria Nicolas, Rut Andrea, Marta Barroso, Raquel Pérez, Sergio Álvarez, Dario Garcia-Gasulla, Adrián Tormos, Luis Tamayo Lomas, Cesar Aldecoa, Rubén Herrán-Monge, José Ángel Berezo García, Pedro Enríquez Giraudo, Pablo Cardinal Fernández, Alberto Rubio López, Orville Báez Pravia, Juan López Messa, Leire Pérez Bastida, Antonjo Alvarez Ruiz, José Trenado, Anna Parera Pous, Cristóbal Galbán, Ana López Lago, Eva Saborido Paz, Patricia Barral Segade, Ana Balan Mariño, Manuel Valledor Mendez, Raúl de Frutos, Luciano Aguilera, Felipe Pérez-García, Esther López-Ramos, Ángela Leonor Ruiz-García, Belén Beteré, Rafael Blancas, Cristina Dólera, Gloria Perez Planelles, Enrique Marmol Peis, Maria Dolores Martinez Juan, Miriam Ruiz Miralles, Eva Perez Rubio, Maria Van der Hofstadt Martin-Montalvo, Ángel Sánchez-Miralles, Tatiana Villada Warrington, Juan Carlos Pozo-Laderas, Angel Estrella, Sara Guadalupe Moreno Cano, Federico Gordo, Basilisa Martinez Palacios, Maite Nieto, Maria Teresa Nieto, Sergio Ossa, Ana Ortega, Miguel Sanchez, and Bitor Santacoloma
Subjects: Microbiology (medical), Infectious Diseases
Published: 2022

28. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author: Gumucio-Sanguino, Víctor D., Mañez, Rafael, Solé-Violan, Jordi, de Castro, Felipe Rodríguez, Suarez-Sipmann, Fernando, García, Ruth Noemí Jorge, Aznar, María Mora, Torres, Mateu, Martinez, María, Alegre, Cynthia, Riera, Jordi, Contreras, Sofía, Pericas, Juan Manuel, Ferrer, Ricard, Caballero, Jesús, Trujillano, Javier, Vallverdú, Montse, León, Miguel, Badía, Mariona, Balsera, Begoña, Servià, Lluís, Vilanova, Judit, Rodríguez, Silvia, Montserrat, Neus, Iglesias, Silvia, Prados, Javier, Carvalho, Sula, Miralbés, Mar, Monclou, Josman, Jiménez, Gabriel, Codina, Jordi, Val, Estela, Pagliarani, Pablo, Rubio, Jorge, Morales, Dulce, Pujol, Andrés, Furro, Àngels, García, Beatriz, Torres, Gerard, Vengoechea, Javier, Gonzalo-Calvo, David de, González, Jessica, Gomez, Silvia, Gómez, José M., Franco, Nieves, Barberán, José, Albaiceta, Guillermo M, Espina, Lorena Forcelledo, Prieto, Emilio García, Vicente, Paula Martín, del Busto Martínez, Cecilia, Vidal-Cortés, Pablo, Garmendia, José Luis García, Cabello, María Aguilar, Fernández, Carmen Eulalia Martínez, Carbonell, Nieves, Cortés, María Luisa Blasco, Lázaro, Ainhoa Serrano, Díaz, Mar Juan, Ortiz, Aaron Blandino, Menendez, Rosario, Valdivia, Luis Jorge, Boado, María Victoria, Chinesta, Susana Sancho, del Carmen de la Torre, Maria, Varela, Ignacio Martínez, Vieiro, María Teresa Bouza, Arijón, Inés Esmorís, Hermoso, David Campi, Salinas, Rafaela Nogueras, Monjo, Teresa Farre, Bou, Ramon Nogue, Naya, Gregorio Marco, Barberà, Carme, Coll, Núria Ramon, Catalán-González, Mercedes, Montejo-González, Juan Carlos, Sanchez-Giron, Gloria Renedo, Bustamante-Munguira, Juan, Bustamante-Munguira, Elena, Avila, Ramon Cicuendez, Herrera, Nuria Mamolar, Almansa, Raquel, Ortega, Alicia, Bermejo-Martin, Jesús, Sagredo, Víctor, Añon, Jose, Agrifoglio, Alexander, Cachafeiro, Lucia, Maseda, Emilio, Socias, Lorenzo, Novo, Mariana Andrea, Figueras, Albert, Janer, Maria Teresa, Soliva, Laura, Ocón, Marta, Clar, Luisa, Ayestarán, J Ignacio, Peñasco, Yhivian, Fernández, Sandra Campos, Serra-Fortuny, Mireia, Forcadell-Ferreres, Eva, Salvador-Adell, Immaculada, Bofill, Neus, Adell-Serrano, Berta, Díaz, Josep Pedregosa, Casacuberta-Barberà, Núria, Urrelo-Cerrón, Luis, Piñol-Tena, Àngels, Roche-Campo, Ferran, de la Gándara, Amalia Martínez, Murúa, Pablo Ryan, Ruíz, Covadonga Rodríguez, García, Laura Carrión, Álvarez, Juan I Lazo, Lorente, José Ángel, Loza-Vázquez, Ana, Guerrero, Desire Macias, Huerta, Arturo, Tognetti, Daniel, Redruello, Carlos García, Rodríguez, David Mosquera, Fernández, Eva María Menor, Adrio, Sabela Vara, Casal, Vanesa Gómez, Pensado, Marta Segura, Vilas, María Digna Rivas, Sagastume, Amaia García, de Pablo Sánchez, Raul, Laguna, David Pestaña, Bardi, Tommaso, Villar, Rosario Amaya, Gonzalez, Carmen Gómez, Castillo, Maria Luisa Gascón, Garnacho-Montero, José, Cantón-Bulnes, María Luisa, Marin-Corral, Judith, Pérez, Cristina Carbajales, Masclans, Joan Ramon, Degracia, Ana Salazar, Bigas, Judit, Muñoz-Bermúdez, Rosana, Vilà-Vilardel, Clara, Parrilla, Francisco, Dot, Irene, Zapatero, Ana, Díaz, Yolanda, Gracia, María Pilar, Pérez, Purificación, Castellví, Andrea, Climent, Cristina, Serra, Lidia, Barbena, Laura, Cano, Iosune, Ricart, Pilar, Herraiz, Alba, Marcos, Pilar, Rodríguez, Laura, Sariñena, Maria Teresa, Sánchez, Ana, Úbeda, Alejandro, Delgado, María Cruz Martin, Gallego, Elena, Jimenez, Juan Fernando Masa, Gomà, Gemma, Díaz, Emi, Ibarz, Mercedes, De Mendoza, Diego, Barbeta, Enric, Alcaraz-Serrano, Victoria, Badia, Joan Ramon, Castella, Manuel, Bueno, Leticia, Ceccato, Adrian, Palomeque, Andrea, Barat, Laia Fernandez, Cillóniz, Catia, Conde, Pamela, Fernández, Javier, Gabarrus, Albert, Kiarostami, Karsa, López-Gavín, Alexandre, Mantellini, Cecilia L, Speziale, Carla, Vázquez, Nil, Yang, Hua, Yang, Minlan, Ferrando, Carlos, Castro, Pedro, Arrieta, Marta, Nicolas, Jose Maria, Andrea, Rut, Barroso, Marta, Pérez, Raquel, Álvarez, Sergio, Garcia-Gasulla, Dario, Tormos, Adrián, Lomas, Luis Tamayo, Aldecoa, Cesar, Herrán-Monge, Rubén, García, José Ángel Berezo, Giraudo, Pedro Enríquez, Fernández, Pablo Cardinal, López, Alberto Rubio, Pravia, Orville Báez, Messa, Juan López, Bastida, Leire Pérez, Ruiz, Antonjo Alvarez, Trenado, José, Pous, Anna Parera, Galbán, Cristóbal, Lago, Ana López, Paz, Eva Saborido, Segade, Patricia Barral, Mariño, Ana Balan, Mendez, Manuel Valledor, de Frutos, Raúl, Aguilera, Luciano, Pérez-García, Felipe, López-Ramos, Esther, Ruiz-García, Ángela Leonor, Beteré, Belén, Blancas, Rafael, Dólera, Cristina, Planelles, Gloria Perez, Peis, Enrique Marmol, Juan, Maria Dolores Martinez, Miralles, Miriam Ruiz, Rubio, Eva Perez, Martin-Montalvo, Maria Van der Hofstadt, Sánchez-Miralles, Ángel, Warrington, Tatiana Villada, Pozo-Laderas, Juan Carlos, Estrella, Angel, Cano, Sara Guadalupe Moreno, Gordo, Federico, Palacios, Basilisa Martinez, Nieto, Maite, Nieto, Maria Teresa, Ossa, Sergio, Ortega, Ana, Sanchez, Miguel, Santacoloma, Bitor, Motos, Anna, Castañeda, Tatiana, Gabarrús, Albert, Barbé, Ferran, and Torres, Antoni
Published: 2023
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29. Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score–Adjusted Analysis of a Multicenter Study*

Author: Garnacho-Montero, José, Díaz-Martín, Ana, Cantón-Bulnes, Luisa, Ramírez, Paula, Sierra, Rafael, Arias-Verdú, Dolores, Rodríguez-Delgado, Marina, Loza-Vázquez, Ana, Rodriguez-Gomez, Jesús, Gordón, Mónica, Estella, Ángel, and García-Garmendia, José Luis
Published: 2018
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30. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19

Author: Victor Daniel Gumucio, Aida Monge, Adrián Ceccato, Maria del Carmen de la Torre, Amara Carratalá, Rosario Amaya Villar, Gonzalo Labarca, Anna Moncusí-Moix, Angel Estella, José Manuel Gómez, José Luis García Garmendia, María Zuil, Juan Lopez Messa, Ana Loza-Vázquez, Judith Marin-Corral, Sally Santisteve, Cristóbal Galbán, Jessica González, Paola Carmona, Jordi Solé-Violán, Pilar Ricart Martí, Carme Barberà, Ferran Barbé, Elena Bustamante-Munguira, Ignacio Martínez Varela, Ferran Roche-Campo, Cristina Carbajales, Jordi Riera, Aaron Blandino Ortiz, Iván Benítez, Arturo Huerta, David de Gonzalo-Calvo, Oscar Peñuelas, Ricard Ferrer, José Garnacho-Montero, Emili Diaz, Jesus F. Bermejo-Martin, Ana Motos, Antoni Torres, Susana Sancho Chinesta, Jesús Caballero, Luis Tamayo Lomas, Guillermo M. Albaiceta, Angel Sánchez-Miralles, Mercedes Catalán-González, Laia Fernandez, Ruth Noemí Jorge García, José Trenado, Nieves Carbonell, Yhivian Peñasco, Amalia Martínez de la Gándara, José Barberán, Rosario Menéndez, Lucía Pinilla, José M. Añón, Clara Gort-Paniello, Fernando Suares Sipmann, Mariana Andrea Novo, Elena Gallego, Gerard Torres, Dario Garcia-Gasulla, Lorenzo Socias, and Juan Carlos Pozo-Laderas
Subjects: Pulmonary and Respiratory Medicine, Mechanical ventilation, medicine.medical_specialty, ARDS, Lung, business.industry, medicine.medical_treatment, Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary function testing, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, Interquartile range, Internal medicine, Diffusing capacity, Medicine, Lung volumes, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Prospective cohort study
Abstract: Background More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear. Research Question What are the major long-term pulmonary sequelae in critical patients who survive COVID-19? Study Design and Methods Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test [6MWT]), and chest CT imaging. Results One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay. Interpretation Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID-19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge.
Published: 2021

31. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author: Benítez, Iván D., Batlle, Jordi de, Torres, Gerard, González, Jessica, Gonzalo Calvo, David de, Targa, Adriano D.S., Gort Paniello, Clara, Moncusí Moix, Anna, Ceccato, Adrian, Fernández Barat, Laia, Ferrer, Ricard, Garcia Gasulla, Dario, Menéndez, Rosario, Motos, Anna, Peñuelas, Oscar, Riera, Jordi, Bermejo Martin, Jesús F., Peñasco, Yhivian, Ricart, Pilar, Martin Delgado, María Cruz, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Suarez Sipmann, Fernando, Pozo Laderas, Juan Carlos, Solé Violan, Jordi, Nieto, Maite, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho Montero, José, García Garmendia, José Luis, Gómez, José M., Lorente, José Ángel, Blandino Ortiz, Aaron, Tamayo Lomas, Luis, López Ramos, Esther, Úbeda, Alejandro, Catalán González, Mercedes, Sánchez Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio Sanguino, Víctor D., Huerta Garcia, Arturo, Bustamante Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Martínez de la Gándara, Amalia, Castellanos Ortega, Álvaro, Trenado, Josep, Marin Corral, Judith, Albaiceta, Guillermo M., De La Torre, Maria Del Carmen, Loza-vázquez, Ana, Vidal, Pablo, Lopez Messa, Juan, Añón, José M., Carbajales Pérez, Cristina, Sagredo, Victor, Bofill, Neus, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Ángel, Valledor Mendez, Manuel, Diaz, Emili, López Lago, Ana, Torres, Antoni, Barbé, Ferran, CIBERESUCICOVID Project (COV20/00110, ISCIII), Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic
Subjects: Informàtica::Intel·ligència artificial::Aprenentatge automàtic [Àrees temàtiques de la UPC], Critical Care, Health Policy, COVID-19, Comorbidity, Prognosis, COVID-19 (Malaltia), COVID-19 (Disease), Medicina intensiva, Oncology, Comorbiditat, Ciències de la salut::Medicina::Medicina comunitària i salut pública [Àrees temàtiques de la UPC], mental disorders, Internal Medicine, Critical care medicine
Abstract: Financial support was provided by Instituto de Salud Carlos III (CIBERESUCICOVID, COV20/00110), co- funded by Fondo Europeo de Desarrollo Regional (FEDER), “Una manera de hacer Europa”, Centro de Investigaci on Biom edica en Red − Enfermedades Res- piratorias (CIBERES) and Donation Program “estar pre- parados”, UNESPA, Madrid, Spain. JdB acknowledges receiving financial support from Instituto de Salud Car- los III (ISCIII; Miguel Servet 2019: CP19/00108), co- funded by the European Social Fund (ESF), “Investing in your future”. DdGC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP20/00041), co-funded by the European Social Fund (ESF), “Investing in your future”. AC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087)., Benítez ID, de Batlle J, Torres G, González J, de Gonzalo-Calvo D, Targa ADS, Gort-Paniello C, Moncusí-Moix A, Ceccato A, Fernández-Barat L, Ferrer R, Garcia-Gasulla D, Menéndez R, Motos A, Peñuelas O, Riera J, Bermejo-Martin JF, Peñasco Y, Ricart P, Martin Delgado MC, Aguilera L, Rodríguez A, Boado Varela MV, Suarez-Sipmann F, Pozo-Laderas JC, Solé-Violan J, Nieto M, Novo MA, Barberán J, Amaya Villar R, Garnacho-Montero J, García-Garmendia JL, Gómez JM, Lorente JÁ, Blandino Ortiz A, Tamayo Lomas L, López-Ramos E, Úbeda A, Catalán-González M, Sánchez-Miralles A, Martínez Varela I, Jorge García RN, Franco N, Gumucio-Sanguino VD, Huerta Garcia A, Bustamante-Munguira E, Valdivia LJ, Caballero J, Gallego E, Martínez de la Gándara A, Castellanos-Ortega Á, Trenado J, Marin-Corral J, Albaiceta GM, de la Torre MDC, Loza-Vázquez A, Vidal P, Lopez Messa J, Añón JM, Carbajales Pérez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barberà C, Estella A, Valledor Mendez M, Diaz E, López Lago A, Torres A, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII)
Published: 2022

32. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author: Benítez, Iván D., primary, de Batlle, Jordi, additional, Torres, Gerard, additional, González, Jessica, additional, de Gonzalo-Calvo, David, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Menéndez, Rosario, additional, Motos, Anna, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Martin Delgado, María Cruz, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Suarez-Sipmann, Fernando, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Nieto, Maite, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, García-Garmendia, Jose Luis, additional, Gómez, José M., additional, Lorente, José Ángel, additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, López-Ramos, Esther, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Huerta Garcia, Arturo, additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Martínez de la Gándara, Amalia, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M, additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Lopez Messa, Juan, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Bofill, Neus, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Valledor Mendez, Manuel, additional, Diaz, Emili, additional, López Lago, Ana, additional, Torres, Antoni, additional, and Barbé, Ferran, additional
Published: 2022
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33. Knowledge-based System for Supervision and Control of a Fed-batch Fermentation of BT.

Author: L. Valdez-Castro, A. Loza-Vázquez, J. M. Rodríguez-Morales, and Josefina Barrera-Cortés
Published: 2003

34. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Author: Antoni, Torres, Ana, Motos, Catia, Cillóniz, Adrián, Ceccato, Laia, Fernández-Barat, Albert, Gabarrús, Jesús, Bermejo-Martin, Ricard, Ferrer, Jordi, Riera, Raquel, Pérez-Arnal, Dario, García-Gasulla, Oscar, Peñuelas, José Ángel, Lorente, David, de Gonzalo-Calvo, Raquel, Almansa, Rosario, Menéndez, Andrea, Palomeque, Rosario Amaya, Villar, José M, Añón, Ana, Balan Mariño, Carme, Barberà, José, Barberán, Aaron, Blandino Ortiz, Maria Victoria, Boado, Elena, Bustamante-Munguira, Jesús, Caballero, María Luisa, Cantón-Bulnes, Cristina, Carbajales Pérez, Nieves, Carbonell, Mercedes, Catalán-González, Raul, de Frutos, Nieves, Franco, Cristóbal, Galbán, Víctor D, Gumucio-Sanguino, Maria Del Carmen, de la Torre, Emili, Díaz, Ángel, Estella, Elena, Gallego, José Luis, García Garmendia, José M, Gómez, Arturo, Huerta, Ruth Noemí Jorge, García, Ana, Loza-Vázquez, Judith, Marin-Corral, María Cruz, Martin Delgado, Amalia, Martínez de la Gándara, Ignacio, Martínez Varela, Juan, López Messa, Guillermo M, Albaiceta, Maite, Nieto, Mariana Andrea, Novo, Yhivian, Peñasco, Felipe, Pérez-García, Juan Carlos, Pozo-Laderas, Pilar, Ricart, Victor, Sagredo, Angel, Sánchez-Miralles, Susana, Sancho Chinesta, Mireia, Serra-Fortuny, Lorenzo, Socias, Jordi, Solé-Violan, Fernando, Suarez-Sipmann, Luis, Tamayo Lomas, José, Trenado, Alejandro, Úbeda, Luis Jorge, Valdivia, Pablo, Vidal, Ferran, Barbé, and Bitor, Santacoloma
Subjects: Infecciones por coronavirus, Critical Illness, Enfermedad transmisible, COVID-19, Critical Care and Intensive Care Medicine, Respiration, Artificial, COVID-19 Drug Treatment, Tratamiento médico, Intensive Care Units, Adrenal Cortex Hormones, Intensive care, Corticosteroids, Humans, Steroids, Precision Medicine, Critically ill
Abstract: Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19. Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment (< 7 days since symptom onset) and long term of corticosteroids (≥ 10 days) were also investigated. Results: Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p < 0.001). Significant effect modification was found after adjustment for covariates using propensity score for age (p = 0.001 interaction term), Sequential Organ Failure Assessment (SOFA) score (p = 0.014 interaction term), and mechanical ventilation (p = 0.001 interaction term). We observed a beneficial effect of corticosteroids on 90-day mortality in various patient subgroups, including those patients aged ≥ 60 years; those with higher baseline severity; and those receiving invasive mechanical ventilation at ICU admission. Early administration was associated with a higher risk of 90-day mortality in the overall population (HR 1.32 [1.14-1.53], p < 0.001). Long-term use was associated with a lower risk of 90-day mortality in the overall population (HR 0.71 [0.61-0.82], p < 0.001). No effect was found regarding the dosage of corticosteroids. Moreover, the use of corticosteroids was associated with an increased risk of nosocomial bacterial pneumonia and hyperglycaemia. Conclusion: Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful. Instituto de Salud Carlos III de Madrid (ISCIII) (COV20/00110) Centro de Investigacion Biomedica En Red-Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III European Commission Miguel Servet 2020: CP20/00041 Instituto de Salud Carlos III (PI19/00207) 41.787 JCR (2022) Q1, 2/35 Critical Care Medicine 4.344 SJR (2022) Q1, 2/98 Critical Care and Intensive Care Medicine No data IDR 2022 UEM
Published: 2022

35. Role of Viral Storm in Critical COVID-19 Illness: A Prospective Cohort Multicentric Study

Author: Jesus F. Bermejo-Martin, Nadia García Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Úbeda-Iglesias, María del Carmen de la Torre, Angel Estella, Sandra Campos-Fernández, Ignacio Martínez Varela, Felipe Pérez-García, Lorenzo Socias, Juan López Messa, Pablo Vidal-Cortés, Víctor Sagredo Meneses, Milagros González-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, María Cruz Martín Delgado, Luis Jorge Valdivia, Caridad Martín-López, Ruth Noemí Jorge García, Emilio Maseda, Ana Loza-Vázquez, david kelvin, Ferran Barbé, Antoni Torres, and CIBERES-UCI-COVID Group
Subjects: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published: 2022

36. Role of Viral Storm in Critical COVID-19 Illness: A Prospective Cohort Multicentric Study

Author: Bermejo-Martin, Jesus F., primary, García Mateo, Nadia, additional, Motos, Anna, additional, Resino, Salvador, additional, Tamayo, Luis, additional, Ryan, Pablo, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Úbeda-Iglesias, Alejandro, additional, de la Torre, María del Carmen, additional, Estella, Angel, additional, Campos-Fernández, Sandra, additional, Martínez Varela, Ignacio, additional, Pérez-García, Felipe, additional, Socias, Lorenzo, additional, Messa, Juan López, additional, Vidal-Cortés, Pablo, additional, Sagredo Meneses, Víctor, additional, González-Rivera, Milagros, additional, Carbonell, Nieves, additional, de Gonzalo-Calvo, David, additional, Martín Delgado, María Cruz, additional, Valdivia, Luis Jorge, additional, Martín-López, Caridad, additional, Jorge García, Ruth Noemí, additional, Maseda, Emilio, additional, Loza-Vázquez, Ana, additional, kelvin, david, additional, Barbé, Ferran, additional, Torres, Antoni, additional, and Group, CIBERES-UCI-COVID, additional
Published: 2022
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37. ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome

Author: Martin-Loeches, Ignacio, primary, Motos, Anna, additional, Menéndez, Rosario, additional, Gabarrús, Albert, additional, González, Jessica, additional, Fernández-Barat, Laia, additional, Ceccato, Adrián, additional, Pérez-Arnal, Raquel, additional, García-Gasulla, Dario, additional, Ferrer, Ricard, additional, Riera, Jordi, additional, Lorente, José, additional, Peñuelas, Óscar, additional, Bermejo-Martin, Jesús, additional, de Gonzalo-Calvo, David, additional, Rodríguez, Alejandro, additional, Barbé, Ferran, additional, Aguilera, Luciano, additional, Amaya-Villar, Rosario, additional, Barberà, Carme, additional, Barberán, José, additional, Blandino Ortiz, Aaron, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Gumucio-Sanguino, Víctor, additional, de la Torre, Maria, additional, Díaz, Emili, additional, Gallego, Elena, additional, García Garmendia, José, additional, Garnacho-Montero, José, additional, Gómez, José, additional, Jorge García, Ruth, additional, Loza-Vázquez, Ana, additional, Marín-Corral, Judith, additional, Martínez de la Gándara, Amalia, additional, Martínez Varela, Ignacio, additional, Lopez Messa, Juan, additional, Albaiceta, Guillermo, additional, Novo, Mariana, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Urrelo-Cerrón, Luis, additional, Sánchez-Miralles, Angel, additional, Sancho Chinesta, Susana, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Tamayo Lomas, Luis, additional, Vidal, Pablo, additional, and Torres, Antoni, additional
Published: 2021
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38. ICU-Acquired Pneumonia is a Risk Factor of a Poor Health Post-Covid-19 Syndrome

Author: José Luis García Garmendia, David de Gonzalo-Calvo, Laia Fernández-Barat, Elena Gallego, Pilar Ricart, Jesus F. Bermejo-Martin, Dario Garcia-Gasulla, Juan Lopez Messa, Ana Loza-Vázquez, Ignacio Martínez Varela, Cristina Carbajales, Víctor D. Gumucio Sanguino, Rosario Amaya Villar, José Barberán, Guillermo M. Albaiceta, Carme Barberà, Lorenzo Socias, Luis Urrelo-Cerrón, Emili Diaz, Raquel Pérez, Yhivian Peñasco, Anna Motos, Amalia Martínez de la Gándara, Ruth Noemí Jorge García, Aaron Blandino Ortiz, José A. Lorente, Jesús Caballero, Ignacio Martin-Loeches, Jordi Riera, Jessica González, Antoni Torres, Elena Bustamante-Munguira, Mariana Andrea Novo, Rosario Menéndez, Alejandro Rodriguez, Judith Marin-Corral, Adrian Ceccato, Luis Tamayo Lomas, Pablo Vidal, Oscar Peñuelas, Ricard Ferrer, Angel Sánchez-Miralles, Maria del Carmen de la Torre, Cristóbal Galbán, Nieves Carbonell, Ferran Barbé, Albert Gabarrus, Susana Sancho Chinesta, Mercedes Catalán-González, Jordi Solé-Violán, José Manuel Gómez, José Garnacho-Montero, and Luciano Aguilera
Subjects: Pneumonia, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, Risk factor, business, medicine.disease, Intensive care medicine
Abstract: Background. Some patients who had previously presented with COVID-19 have been reported to develop persistent COVID-19 symptoms. Whilst this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the prevalence and risk factors and characteristics of persistent COVID_19 . On other hand these patients have very often intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence in the poor health post-Covid 19 syndrome in ICU discharged patientsMethods: This prospective, multicentre and observational study was done across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1,255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP) Patients requiring invasive mechanical ventilation had persistent, post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, and development of ICUAP were independent risk factors for persistent poor health post-COVID-19.Conclusions: Persistent, post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay and the onset of ICUAP comprised all independent risk factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-Covid 19
Published: 2021

39. ICU-Acquired Pneumonia is a Risk Factor of a Poor Health Post-Covid-19 Syndrome

Author: Martin-Loeches, Ignacio, primary, Motos, Anna, additional, Menéndez, Rosario, additional, Gabarrus, Albert, additional, González, Jessica, additional, Fernández-Barat, Laia, additional, Ceccato, Adrián, additional, Pérez, Raquel, additional, García-Gasulla, Dario, additional, Ferrer, Ricard, additional, Riera, Jordi, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Bermejo-Martin, Jesús F, additional, de Gonzalo-Calvo, David, additional, Rodríguez, Alejandro, additional, Barbé, Ferran, additional, Aguilera, Luciano, additional, Villar, Rosario Amaya, additional, Barberà, Carme, additional, Barberán, José, additional, Ortiz, Aaron Blandino, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Sanguino, Víctor D. Gumucio, additional, Torre, Maria del Carmen de la, additional, Díaz, Emili, additional, Gallego, Elena, additional, Garmendia, José Luis García, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, García, Ruth Noemí Jorge, additional, Loza-Vázquez, Ana, additional, Marin-Corral, Judith, additional, Gándara, Amalia Martínez de la, additional, Varela, Ignacio Martínez, additional, Messa, Juan Lopez, additional, Albaiceta, Guillermo M, additional, Novo, Mariana Andrea, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Urrelo-Cerrón, Luis, additional, Sánchez-Miralles, Angel, additional, Chinesta, Susana Sancho, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Lomas, Luis Tamayo, additional, Vidal, Pablo, additional, and Torres, Antoni, additional
Published: 2021
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40. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19

Author: González, Jessica, primary, Benítez, Iván D., additional, Carmona, Paola, additional, Santisteve, Sally, additional, Monge, Aida, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Pinilla, Lucía, additional, Carratalá, Amara, additional, Zuil, María, additional, Ferrer, Ricard, additional, Ceccato, Adrián, additional, Fernández, Laia, additional, Motos, Ana, additional, Riera, Jordi, additional, Menéndez, Rosario, additional, Garcia-Gasulla, Dario, additional, Peñuelas, Oscar, additional, Bermejo-Martin, Jesús F., additional, Labarca, Gonzalo, additional, Caballero, Jesus, additional, Torres, Gerard, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Villar, Rosario Amaya, additional, Añón, José M., additional, Barberà, Carme, additional, Barberán, José, additional, Ortiz, Aaron Blandino, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Gumucio, Victor Daniel, additional, de la Torre, Maria del Carmen, additional, Díaz, Emili, additional, Estella, Ángel, additional, Gallego, Elena, additional, García Garmendia, José Luis, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Huerta, Arturo, additional, Jorge García, Ruth Noemí, additional, Loza-Vázquez, Ana, additional, Marin-Corral, Judith, additional, de la Gándara, Amalia Martínez, additional, Varela, Ignacio Martínez, additional, Messa, Juan Lopez, additional, Albaiceta, Guillermo M., additional, Novo, Mariana Andrea, additional, Peñasco, Yhivian, additional, Pozo-Laderas, Juan Carlos, additional, Martí, Pilar Ricart, additional, Roche-Campo, Ferran, additional, Sánchez-Miralles, Angel, additional, Chinesta, Susana Sancho, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Sipmann, Fernando Suares, additional, Lomas, Luis Tamayo, additional, and Trenado, José, additional
Published: 2021
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41. Additional file 1 of The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author: Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández-Barat, Laia, Ceccato, Adrián, Pérez-Arnal, Raquel, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Angel, Rodriguez, Alejandro, de Gonzalo-Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo-Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, M. Albaiceta, Guillermo, Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Salvador-Adell, Inmaculada, Sánchez-Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé-Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, and Barbé, Ferran
Subjects: ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract: Additional file 1. Supplementary tables and figures.
Published: 2021
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42. En respuesta a: «Variables asociadas al pronóstico tras parada cardíaca»

Author: Loza-Vázquez, A., primary, Macias-Guerrero, D., additional, and León-Gil, C., additional
Published: 2021
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43. In reply to “Variables associated with survival free of severe neurological sequelae in patients recovered from cardiac arrest”

Author: Loza-Vázquez, A., primary, Macias-Guerrero, D., additional, and León-Gil, C., additional
Published: 2021
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44. En respuesta a: «Variables asociadas al pronóstico tras parada cardíaca»

Author: C. León-Gil, A. Loza-Vázquez, and D. Macias-Guerrero
Subjects: Gynecology, medicine.medical_specialty, business.industry, Medicine, Critical Care and Intensive Care Medicine, business
Published: 2021

45. In reply to 'Variables associated with survival free of severe neurological sequelae in patients recovered from cardiac arrest'

Author: C. León-Gil, D. Macias-Guerrero, and A. Loza-Vázquez
Subjects: medicine.medical_specialty, business.industry, Internal medicine, medicine, MEDLINE, In patient, business
Published: 2021

46. Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study.

Author: Moreno, Gerard, Carbonell, Raquel, Martin-Loeches, Ignacio, Solé-Violán, Jordi, Correig i Fraga, Eudald, Gómez, Josep, Ruiz-Botella, Manuel, Trefler, Sandra, Bodí, María, Murcia Paya, Josefa, Díaz, Emili, Vidal-Cortes, Pablo, Papiol, Elisabeth, Albaya Moreno, Antonio, Sancho Chinesta, Susana, Socias Crespi, Lorenzo, Lorente, María del Carmen, Loza Vázquez, Ana, Vara Arlanzon, Rebeca, and Recio, María Teresa
Subjects: ADULT respiratory distress syndrome, ARTIFICIAL respiration, COVID-19, CORTICOSTEROIDS, LENGTH of stay in hospitals
Abstract: Background: Some unanswered questions persist regarding the effectiveness of corticosteroids for severe coronavirus disease 2019 (COVID-19) patients. We aimed to assess the clinical effect of corticosteroids on intensive care unit (ICU) mortality among mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients. Methods: This was a retrospective study of prospectively collected data conducted in 70 ICUs (68 Spanish, one Andorran, one Irish), including mechanically ventilated COVID-19-associated ARDS patients admitted between February 6 and September 20, 2020. Individuals who received corticosteroids for refractory shock were excluded. Patients exposed to corticosteroids at admission were matched with patients without corticosteroids through propensity score matching. Primary outcome was all-cause ICU mortality. Secondary outcomes were to compare in-hospital mortality, ventilator-free days at 28 days, respiratory superinfection and length of stay between patients with corticosteroids and those without corticosteroids. We performed survival analysis accounting for competing risks and subgroup sensitivity analysis. Results: We included 1835 mechanically ventilated COVID-19-associated ARDS, of whom 1117 (60.9%) received corticosteroids. After propensity score matching, ICU mortality did not differ between patients treated with corticosteroids and untreated patients (33.8% vs. 30.9%; p = 0.28). In survival analysis, corticosteroid treatment at ICU admission was associated with short-term survival benefit (HR 0.53; 95% CI 0.39–0.72), although beyond the 17th day of admission, this effect switched and there was an increased ICU mortality (long-term HR 1.68; 95% CI 1.16–2.45). The sensitivity analysis reinforced the results. Subgroups of age < 60 years, severe ARDS and corticosteroids plus tocilizumab could have greatest benefit from corticosteroids as short-term decreased ICU mortality without long-term negative effects were observed. Larger length of stay was observed with corticosteroids among non-survivors both in the ICU and in hospital. There were no significant differences for the remaining secondary outcomes. Conclusions: Our results suggest that corticosteroid treatment for mechanically ventilated COVID-19-associated ARDS had a biphasic time-dependent effect on ICU mortality. Specific subgroups showed clear effect on improving survival with corticosteroid use. Therefore, further research is required to identify treatment-responsive subgroups among the mechanically ventilated COVID-19-associated ARDS patients. [ABSTRACT FROM AUTHOR]
Published: 2021
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47. Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score-Adjusted Analysis of a Multicenter Study*

Author: Dolores Arias-Verdú, Ana Loza-Vázquez, Monica Gordon, Angel Estella, José Garnacho-Montero, Paula Ramirez, Ana Díaz-Martín, Jesús Rodriguez-Gomez, Rafael Sierra, Jose Luis García-Garmendía, Marina Rodríguez-Delgado, and Luisa Cantón-Bulnes
Subjects: 0301 basic medicine, Antifungal, medicine.medical_specialty, genetic structures, Echinocandin, medicine.drug_class, 030106 microbiology, Critical Care and Intensive Care Medicine, intensive care unit, 03 medical and health sciences, de-escalation therapy, polycyclic compounds, medicine, Intensive care medicine, Critically ill, business.industry, candidemia, Retrospective cohort study, bacterial infections and mycoses, mortality, antifungal therapy, Multicenter study, Propensity score matching, Observational study, business, Fluconazole, medicine.drug
Abstract: Objective: The objective of this study was to evaluate the impact of the empirical therapy with fluconazole or an echinocandin on 30- and 90-day mortality in critically ill patients with candidemia. The outcome of patients in whom the empirical echinocandin was deescalated to fluconazole was also assessed. Design: Retrospective, observational multicenter study. Setting: Medical and surgical ICUs in nine Spanish hospitals. Patients: Adult patients ( 18 yr) with an episode of Candida bloodstream infection during ICU admission from January 2011 to April 2016. Interventions: Patient characteristics, infection-related variables, therapeutic interventions, and metastatic complications were reviewed. A propensity score-adjusted multivariable analysis was performed to identify the risk factors significantly associated with 30-day and 90-day mortality. Measurements and Main Results: A total of 294 patients were diagnosed of candidemia in the participant ICUs. Sixty patients were excluded (other antifungals in the primary therapy or the patient died without empirical antifungal therapy). The study group comprised 115 patients who received fluconazole (30-day mortality, 37.4%) and 119 patients treated empirically with an echinocandin (30-day mortality, 31.9%). The use of an echinocandin in the empirical therapy was a protective factor for 30-day (odds ratio, 0.32; 95% CI, 0.16-0.66; p = 0.002) and 90-day mortality (odds ratio, 0.50; 95% CI, 0.27-0.93; p = 0.014) in the propensity score- adjusted multivariable analysis. Deescalation of the empirical echinocandin to fluconazole was not associated with a higher mortality or the occurrence of long-term complications. Conclusions: Empirical use of an echinocandin in critically ill patients with documented candidemia reduces mortality at 30 and 90 days significantly. Deescalation of the empirical echinocandin to fluconazole is safe and effective in fluconazole-susceptible infections.
Published: 2018

48. Edema pulmonar neurogénico y shock cardiogénico asociado a brote de esclerosis múltiple

Author: A. Lesmes-Serrano, A.B. Bárcena-Atalaya, A. Loza-Vázquez, and J. Gómez-Rubio
Subjects: Pathology, medicine.medical_specialty, business.industry, Medicine, Critical Care and Intensive Care Medicine, business
Published: 2015

49. Peritonitis candidiásica

Author: Cristóbal León Gil, Alejandro Ubeda, and Ana Loza Vázquez
Subjects: Microbiology (medical), business.industry, Abdominal Infection, Exogenous bacteria, Peritonitis, Dehiscence, medicine.disease, Microbiology, Sepsis, Etiology, Medicine, Colonization, business, Pathogen
Abstract: Candida spp. is a component of the endogenous flora of the digestive tract and can consequently form part of the etiology of almost any type of abdominal infection. Candida spp. is therefore frequently isolated in polymicrobial secondary peritonitis due to intestinal suture dehiscence. In these cases, there is no clear consensus on when Candida spp. isolation in peritoneal drainage fluid represents infection rather than colonization. The general recommendation is to interpret that there is infection when the sample containing the pathogen is intraoperative or has been obtained directly from the intraabdominal collection. When Candida spp. is cultured in samples from subsequently obtained drainage fluid, colonization is a possibility. However, when these cultures are accompanied by signs of sepsis, the patient shows severity criteria or Candida spp. is repeatedly isolated, most intensivists decide to begin antifungal therapy. This treatment is similar for candidemias, disseminated invasive candidiasis and Candida peritonitis.
Published: 2010

50. Documento de Consenso (SEMES-SEMICYUC). Recomendaciones del manejo diagnóstico-terapéutico inicial y multidisciplinario de la sepsis grave en los Servicios de Urgencias hospitalarios

Author: C. León Gil, Alejandro Jimenez, M Moya Mir, M. Chanovas Borras, A Artigas Raventós, F.J. Candel González, M. Sánchez García, A. Loza Vázquez, R. Ferrer Roca, L. Garcia-Castrillo Riesgo, and M Borges Sa
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Critical Care and Intensive Care Medicine, business
Published: 2007

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