Search

Your search keyword '"Lowry, Stephen F."' showing total 997 results
Start Over Author "Lowry, Stephen F."
997 results on '"Lowry, Stephen F."'

2. Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection

Author

Sawyer, Robert G, Claridge, Jeffrey A, Nathens, Avery B, Rotstein, Ori D, Duane, Therese M, Evans, Heather L, Cook, Charles H, O’Neill, Patrick J, Mazuski, John E, Askari, Reza, Wilson, Mark A, Napolitano, Lena M, Namias, Nicholas, Miller, Preston R, Dellinger, E Patchen, Watson, Christopher M, Coimbra, Raul, Dent, Daniel L, Lowry, Stephen F, Cocanour, Christine S, West, Michaela A, Banton, Kaysie L, Cheadle, William G, Lipsett, Pamela A, Guidry, Christopher A, and Popovsky, Kimberley

Subjects
Prevention, Infectious Diseases, Infection, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Appendicitis, Drug Administration Schedule, Female, Fever, Humans, Intraabdominal Infections, Kaplan-Meier Estimate, Leukocytosis, Male, Medication Adherence, Middle Aged, Peritonitis, Recurrence, Sepsis, Surgical Wound Infection, Young Adult, STOP-IT Trial Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThe successful treatment of intraabdominal infection requires a combination of anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy remains unclear.MethodsWe randomly assigned 518 patients with complicated intraabdominal infection and adequate source control to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 days of therapy (control group), or to receive a fixed course of antibiotics (experimental group) for 4±1 calendar days. The primary outcome was a composite of surgical-site infection, recurrent intraabdominal infection, or death within 30 days after the index source-control procedure, according to treatment group. Secondary outcomes included the duration of therapy and rates of subsequent infections.ResultsSurgical-site infection, recurrent intraabdominal infection, or death occurred in 56 of 257 patients in the experimental group (21.8%), as compared with 58 of 260 patients in the control group (22.3%) (absolute difference, -0.5 percentage point; 95% confidence interval [CI], -7.0 to 8.0; P=0.92). The median duration of antibiotic therapy was 4.0 days (interquartile range, 4.0 to 5.0) in the experimental group, as compared with 8.0 days (interquartile range, 5.0 to 10.0) in the control group (absolute difference, -4.0 days; 95% CI, -4.7 to -3.3; P

Published
2015

4. Application of Genome-Wide Expression Analysis to Human Health and Disease

Author

Cobb, J. Perren, Mindrinos, Michael N., Miller-Graziano, Carol, Calvano, Steve E., Baker, Henry V., Xiao, Wenzhong, Laudanski, Krzysztof, Brownstein, Bernard H., Elson, Constance M., Hayden, Douglas L., Herndon, David N., Lowry, Stephen F., Maier, Ronald V., Schoenfeld, David A., Moldawer, Lyle L., Davis, Ronald W., and Tompkins, Ronald G.

Published
2005

5. Mediators of Inflammation and Injury

Author

Lowry, Stephen F., Lin, Edward, Calvano, Steve E., Norton, Jeffrey A., editor, Barie, Philip S., editor, Bollinger, R. Randal, editor, Chang, Alfred E., editor, Lowry, Stephen F., editor, Mulvihill, Sean J., editor, Pass, Harvey I., editor, and Thompson, Robert W., editor

Published
2008
Full Text
View/download PDF

6. Substrate Metabolism

Author

Lin, Edward, Lowry, Stephen F., Norton, Jeffrey A., editor, Barie, Philip S., editor, Bollinger, R. Randal, editor, Chang, Alfred E., editor, Lowry, Stephen F., editor, Mulvihill, Sean J., editor, Pass, Harvey I., editor, and Thompson, Robert W., editor

Published
2008
Full Text
View/download PDF

7. Colon and Rectum

Author

Lowry, Stephen F., Eisenstat, Theodore E., Lowry, Stephen F., editor, Ciocca, Rocco G., editor, Rettie, Candice S., editor, and Vodarsik, Micki, editor

Published
2005
Full Text
View/download PDF

9. Perianal Complaints

Author

Lowry, Stephen F., Eisenstat, Theodore E., Lowry, Stephen F., editor, Ciocca, Rocco G., editor, Rettie, Candice S., editor, and Vodarsik, Micki, editor

Published
2005
Full Text
View/download PDF

11. Mediators of Inflammation and Injury

Author

Lin, Edward, Lowry, Stephen F., Calvano, Steve E., Norton, Jeffrey A., editor, Bollinger, R. Randal, editor, Chang, Alfred E., editor, Lowry, Stephen F., editor, Mulvihill, Sean J., editor, Pass, Harvey I., editor, and Thompson, Robert W., editor

Published
2001
Full Text
View/download PDF

12. Substrate Metabolism in Surgery

Author

Lin, Edward, Lowry, Stephen F., Norton, Jeffrey A., editor, Bollinger, R. Randal, editor, Chang, Alfred E., editor, Lowry, Stephen F., editor, Mulvihill, Sean J., editor, Pass, Harvey I., editor, and Thompson, Robert W., editor

Published
2001
Full Text
View/download PDF

15. Genomic responses in mouse models poorly mimic human inflammatory diseases

Author

Seok, Junhee, Warren, H. Shaw, Cuenca, Alex G., Mindrinos, Michael N., Baker, Henry V., Xu, Weihong, Richards, Daniel R., McDonald-Smith, Grace P., Gao, Hong, Hennessy, Laura, Finnerty, Celeste C., López, Cecilia M., Honari, Shari, Moore, Ernest E., Minei, Joseph P., Cuschieri, Joseph, Bankey, Paul E., Johnson, Jeffrey L., Sperry, Jason, Nathens, Avery B., Billiar, Timothy R., West, Michael A., Jeschke, Marc G., Klein, Matthew B., Gamelli, Richard L., Gibran, Nicole S., Brownstein, Bernard H., Miller-Graziano, Carol, Calvano, Steve E., Mason, Philip H., Cobb, J. Perren, Rahme, Laurence G., Lowry, Stephen F., Maier, Ronald V., Moldawer, Lyle L., Herndon, David N., Davis, Ronald W., Xiao, Wenzhong, and Tompkins, Ronald G.

Published
2013

16. Malnutrition

Author

Fong, Yuman, Lowry, Stephen F., Kirkwood, John M., Lotze, Michael T., and Yasko, Joyce M.

Published
2001
Full Text
View/download PDF

18. Tumor Necrosis Factor as a Mediator of Sepsis

Author

Lowry, Stephen F., VanZee, Kimberly J., Rock, Craig S., Thompson, William A., Oldenburg, Hester S. A., Rogy, Michael A., Moldawer, Lyle L., Schlag, Günther, editor, Redl, Heinz, editor, and Traber, Daniel, editor

Published
1993
Full Text
View/download PDF

35. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways

Author

Laudanski, Krzysztof, Miller-Graziano, Carol, Xiao, Wenzhong, Mindrinos, Michael N., Richards, Daniel R., De, Asit, Moldawer, Lyle L., Maier, Ronald V., Bankey, Paul, Baker, Henry V., Brownstein, Bernard H., Cobb, J. Perren, Calvano, Steve E., Davis, Ronald W., Tompkins, Ronald G., Billiar, Timothy R., Camp, David, II, Campbell-Finnerty, Celeste, Casella, George, Chaudry, Irshad H., Choudhry, Mashkoor, Elson, Constance, Freeman, Bradley, Gamelli, Richard L., Gibran, Nicole S., Harbrecht, Brian G., Hayden, Douglas L., Herndon, David N., Horton, Jureta W., Hubbard, William, Hunt, John Lee, Johnson, Jeffrey, Klein, Matthew B., Lederer, James A., Logvinenko, Tanya, Lowry, Stephen F., Mannick, John A., Mason, Philip H., McDonald-Smith, Grace P., McKinley, Bruce A., Minei, Joseph P., Moore, Ernest E., Moore, Frederick A., Nathens, Avery B., O'Keefe, Grant E., Rahme, Laurence G., Remick, Daniel G., Jr., Schoenfeld, David A., Shapiro, Michael B., Schwacha, Martin, Silver, Geoffrey M., Smith, Richard D., Storey, John, Toner, Mehmet, Warren, H. Shaw, and West, Michael A.

Subjects
T cells -- Research, Immunosuppression -- Research, Monocytes -- Research, Science and technology
Abstract

Monitoring genome-wide, cell-specific responses to human disease, although challenging, holds great promise for the future of medicine. Patients with injuries severe enough to develop multiple organ dysfunction syndrome have multiple immune derangements, including T cell apoptosis and anergy combined with depressed monocyte antigen presentation. Genome-wide expression analysis of highly enriched circulating leukocyte subpopulations, combined with cell-specific pathway analyses, offers an opportunity to discover leukocyte regulatory networks in critically injured patients. Severe injury induced significant changes in T cell (5,693 genes), monocyte (2,801 genes), and total leukocyte (3,437 genes) transcriptomes, with only 911 of these genes common to all three cell populations (12%). T cell-specific pathway analyses identified increased gene expression of several inhibitory receptors (PD-1, CD152, NRP-1, and Lag3) and concomitant decreases in stimulatory receptors (CD28, CD4, and IL-2R[alpha]). Functional analysis of T cells and monocytes confirmed reduced T cell proliferation and increased cell surface expression of negative signaling receptors paired with decreased monocyte costimulation ligands. Thus, genome-wide expression from highly enriched cell populations combined with knowledge-based pathway analyses leads to the identification of regulatory networks differentially expressed in injured patients. Importantly, application of cell separation, genome-wide expression, and cell-specific pathway analyses can be used to discover pathway alterations in human disease. anergy | apoptosis | costimulatory receptors | immunosuppression | network analysis

Published
2006

44. Neutralization of TNF does not influence endotoxin-induced changes in thyroid hormone metabolism in humans

Author

Van Der Poll, Tom, Endert, Erik, Coyle, Susette M., Agosti, Jan M., and Lowry, Stephen F.

Subjects
Tumor necrosis factor -- Research, Thyrotropin -- Research, Endotoxins -- Research, Biological sciences
Abstract

Endogenous tumor necrosis factor (TNF) has no causal link to changes in plasma thyroid hormone and thyroid stimulating hormone concentrations induced by intravenous injection of endotoxin in healthy humans. The results suggest that although TNF can apparently reproduce changes in thyroid hormone and TSH levels found in a class of diseases commonly called euthyroid sick syndrome, endogenous TNF is not needed for these alterations. Therefore, therapeutic interference with TNF activity in euthyroid sick syndrome will not necessarily alter the syndrome.

Published
1999

49. Essential Practice of Surgery

Author

Li, Michelle, primary, Norton, Jeffrey A., additional, Bollinger, R. Randal, additional, Chang, Alfred E., additional, Lowry, Stephen F., additional, Mulvihill, Sean J., additional, Pass, Harvey I., additional, and Thompson, Robert W., additional

Published
2003
Full Text
View/download PDF

50. Epinephrine inhibits endotoxin-induced IL-1beta production: roles of tumor necrosis factor-alpha and IL-10

Author

Van der poll, Tom and Lowry, Stephen F.

Subjects
Epinephrine -- Research, Interleukin-1 -- Research, Endotoxins -- Research, Biological sciences
Abstract

Research shows that biochemical epinephrine causes a marked reduction in cytokine interleukin-1beta production in the presence of circulatory lipopolysaccharide. Experiments using male subjects indicate that epinephrine's stimulatory action is mediated by adrenergic receptors. The physiological effects of anti-tumor necrosis factor and anti-interleukin-10 are assessed.

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results