Author: "Lowman, Warren" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Lowman, Warren"' showing total 179 results

Start Over Author "Lowman, Warren"

179 results on '"Lowman, Warren"'

1. In vitro activity of ceftazidime-avibactam against clinical isolates of Enterobacterales and Pseudomonas aeruginosa from sub-Saharan Africa: ATLAS Global Surveillance Program 2017–2021

Author: Wise, Mark G., Karlowsky, James A., Hackel, Meredith A., Harti, Mohamed Amine, Ntshole, Bontle M.E., Njagua, Eva Njeri, Oladele, Rita, Samuel, Catherine, Khan, Shameema, Wadula, Jeannette, Lowman, Warren, Lembede, Busisani W., and Sahm, Daniel F.
Published: 2023
Full Text: View/download PDF

2. Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungaemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study

Author: Abrahams, Shareef, Ahmed, Khatija, Avenant, Theunis, Bamford, Colleen, Bhola, Prathna, Bishop, Kate, Black, John, Blumberg, Lucille, Bosman, Norma, Botha, Maria, Brink, Adrian, Budavari, Suzy, Burra, Asmeeta, Chibabhai, Vindana, Chomba, Rispah, Cohen, Cheryl, Coovadia, Yacoob, Crowther-Gibson, Penny, Dawood, Halima, de Gouveia, Linda, Dlamini, Nomonde, Dlamini, Siyanda, Dreyer, Andries, du Plessis, Nicolette, du Plessis, Erna, du Plessis, Mignon, Erasmus, Linda, Feldman, Charles, Govender, Nelesh, Govind, Chetna, Groome, Michelle, Haffejee, Sumayya, Hamese, Ken, Haumann, Carel, Hoho, Nombulelo, Hoosen, Anwar, Hoosien, Ebrahim, Howell, Victoria, Hoyland, Greta, Ismail, Farzana, Ismail, Husna, Ismail, Nazir, Ive, Prudence, Jooste, Pieter, Karstaedt, Alan, Khantsi, Ignatius, Kleinhans, Vicky, Kleynhans, Jackie, Kolojane, Molebogeng, Kufa-Chakezha, Tendesayi, Lebaka, Tiisetso, Lebudi, Jacob, Legare, Neo, Lekalakala, Ruth, Lindeque, Kathy, Lowman, Warren, Madhi, Shabir, Magobo, Rindidzani, Mahabeer, Prasha, Maharaj, Adhil, Makgoba, Martha, Maloba, Molatji, Maluleka, Caroline, Manaka, Mokupi, Mangena, Phetho, Maningi, Nontuthuko, Marcus, Louis, Marshall, Terry, Mathebula, Rudzani, Mathunjwa, Azwifarwi, Mbelle, Nontombi, Mbuthu, Bongani, McCarthy, Kerrigan, Meiring, Susan, Mekgoe, Omphile, Menezes, Colin, Miller, Cecilia, Mlisana, Koleka, Moncho, Masego, Moore, David, Moremi, Myra, Morris, Lynn, Moshe, Moamokgethi, Mothibi, Lesego, Moultrie, Harry, Mpembe, Ruth, Mutevedzi, Portia, Mwansa-Kambafwile, Judith, Naby, Fathima, Naicker, Preneshni, Naidoo, Romola, Nana, Trusha, Nchabeleng, Maphoshane, Ndlovu, Phathutshedzo, Nel, Jeremy, Ngomane, Mimmy, Ngubane, Wendy, Nicol, Mark, Njikho, Sunnieboy, Ntlemo, Grace, Ntuli, Sindi, Page, Nicola, Paulse, Nuraan, Pearce, Vanessa, Perovic, Olga, Pillay, Keshree, Pombo, Dina, Poswa, Xoliswa, Prentice, Elizabeth, Puren, Adrian, Quan, Vanessa, Ramjathan, Praksha, Ramkillawan, Yeishna, Reddy, Kessendri, Reubenson, Gary, Richards, Lauren, Said, Mohammed, Samodien, Nazlee, Samuel, Catherine, Seetharam, Sharona, Sekwadi, Phuti, Selekisho, Mirriam, Senekal, Marthinus, Shuping, Liliwe, Sibiya, Ngoaka, Sirkar, Surendra, Smit, Juanita, Smith, Anthony, Smith, Marshagne, Sookan, Lisha, Sriruttan, Charlotte, Stacey, Sarah, Swe Han, Khine Swe, Thomas, Teena, Thomas, Juno, Tsisti, Merika, van Schalkwyk, Erika, Variava, Ebrahim, Vazi, Phumeza, Verwey, Charl, von Gottberg, Anne, Wadula, Jeanntte, Walaza, Sibongile, Wende, Linda, Whitelaw, Andrew, Wilson, Douglas, Zietsman, Inge, Paccoud, Olivier, Mashau, Rudzani, Greene, Greg, and Govender, Nelesh P.
Published: 2023
Full Text: View/download PDF

3. Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Author: Paul, Mical, Carratala, Jordi, Oriol, Isabel, Rodríguez-Álvarez, Regino José, Cordero, Elisa, Lepe, José Antonio, de Lucas, Esperanza Merino, Muñoz, Patricia, Fortún, Jesús, Coussement, Julien, Dewispelaere, Laurent, Eriksson, Britt Marie, van Delden, Christian, Manuel, Oriol, Clemente, Wanessa T., Strabelli, Tania Mara Varejão, Pilmis, Benoit, Roilides, Emmanuel, Ranganathan N, Iyer, Grossi, Paolo A., Soldani, Fabio, Rizzi, Marco, Tan, Ban Hock, Lowman, Warren, Gunseren, Filiz, Arslan, Hande, Tufan, Zeliha Koçak, Kazak, Esra, David, Miruna D., Steinke, Seema Mehta, Ostrander, Darin, Avery, Robin, Lease, Erika D., Pérez-Nadales, Elena, Fernández-Ruiz, Mario, Natera, Alejandra M., Gutiérrez-Gutiérrez, Belén, Mularoni, Alessandra, Russelli, Giovanna, Pierrotti, Ligia Camera, Pinheiro Freire, Maristela, Falcone, Marco, Tiseo, Giusy, Tumbarello, Mario, Raffaelli, Francesca, Abdala, Edson, Bodro, Marta, Gervasi, Elena, Fariñas, María Carmen, Seminari, Elena M., Castón, Juan José, Marín-Sanz, Juan Antonio, Gálvez-Soto, Víctor, Rana, Meenakshi M., Loeches, Belén, Martín-Dávila, Pilar, Pascual, Álvaro, Rodríguez-Baño, Jesús, Aguado, José María, Martínez-Martínez, Luis, and Torre-Cisneros, Julián
Published: 2023
Full Text: View/download PDF

4. Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study

Author: Abrahams, Shareef, Pearce, Vanessa, Moncho, Masego, Wadula, Jeanette, Maloba, Motlatji, Hoosen, Anwar, Verwey, Charl, Menezes, Colin, Moore, David, Pombo, Dina, Reubenson, Gary, Ntlemo, Grace, Richards, Lauren, Nchabeleng, Maphoshane, Tsitsi, Merika, Moshe, Moamokgethi, Said, Mohammed, Kolojane, Molebogeng, Mothibi, Lesego, Du Plessis, Nicolette, Chomba, Rispah, Thomas, Teena, Avenant, Theunis, Nana, Trusha, Chibabhai, Vindana, Maharj, Adhil, Wilson, Douglas, Naby, Fathima, Dawood, Halima, Han, Khine Swe Swe, Sookan, Lisha, Dlamini, Nomonde, Ramajathan, Praksha, Mahabeer, Prasha, Bhola, Prathna, Naidoo, Romola, Haffejee, Sumayya, Sirkar, Surendra, Ramkillawan, Yeishna, Hamese, Ken, Sibiya, Ngoaka, Mangena, Phetho, Lekalakala, Ruth, Hoyland, Greta, Ntuli, Sindi, Variava, Ebrahim, Khantsi, Ignatius, Mekgoe, Omphile, Brink, Adrian, Prentice, Elizabeth, Reddy, Kessendri, Whitelaw, Andrew, Hoosien, Ebrahim, Zietsman, Inge, Marshall, Terry, Poswa, Xoliswa, Govind, Chetna, Smit, Juanita, Pillay, Keshree, Seetharam, Sharona, Howell, Victoria, Samuel, Catherine, Senekal, Marthinus, Bamford, Colleen, Dreyer, Andries, Marcus, Louis, Lowman, Warren, von Gottberg, Anne, Smith, Anthony, Mathunjwa, Azwifarwi, d'Abreu, Cecilia, Miller, Cecilia, Cohen, Cheryl, Ismail, Farzana, Moultrie, Harry, Ismail, Husna, Weyer, Jacqueline, Kleynhans, Jackie, Rossouw, Jenny, Frean, John, Ebonwu, Joy, Mwansa-Kambafwile, Judith, Thomas, Juno, Bishop, Kate, McCarthy, Kerrigan, Shuping, Liliwe, de Gouveia, Linda, Erasmus, Linda, Puren, Adrian, Blumberg, Lucille, Smith, Marshagne, Makgoba, Martha, Groome, Michelle, du Plessis, Mignon, Ngomane, Mimmy, Manaka, Mokupi, Moremi, Myra, Ismail, Nazir, Legare, Neo, Page, Nicola, Hoho, Nombulelo, Perovic, Olga, Sekwadi, Phuti, Magobo, Rindidzani, Mpembe, Ruth, Walaza, Sibongile, Dlamini, Siyanda, Njikho, Sunnieboy, Lebaka, Tiisetso, Ngubane, Wendy, Mashau, Rudzani C, Meiring, Susan T, Quan, Vanessa C, Nel, Jeremy, Greene, Greg S, Garcia, Andrea, Reddy, Denasha L, Venter, Michelle, Stacey, Sarah, Madua, Matamela, Boretti, Lia, Harrison, Thomas S, Meintjes, Graeme, Shroufi, Amir, Trivino-Duran, Laura, Black, John, and Govender, Nelesh P
Published: 2022
Full Text: View/download PDF

5. In vitro activity of ceftaroline against bacterial pathogens isolated from patients with skin and soft tissue and respiratory tract infections in the Middle East and Africa: AWARE global surveillance programme 2015–2018

Author: Karlowsky, James A., Hackel, Meredith A., Bouchillon, Samue l K., Lowman, Warren, Kotb, Ramy El Mahdy, Mohamed, Naglaa, Stone, Gregory G., and Sahm, Daniel F.
Published: 2021
Full Text: View/download PDF

6. Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia

Author: Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M., Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N., Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, Costa-Mateo, José María, Rana, Meenakshi M., Mara Varejão Strabelli, Tania, Paul, Mical, Carmen Fariñas, María, Clemente, Wanessa Trindade, Roilides, Emmanuel, Muñoz, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Antonio Grossi, Paolo, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Luis, Aguado, JoséMaría, Rodríguez-Baño, Jesús, and Torre-Cisneros, Julián
Published: 2020
Full Text: View/download PDF

7. The Value and Interpretation of Microbiological Specimens in the Management of cIAI

Author: Lowman, Warren, Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W, Series Editor, Di Saverio, Salomone, Series Editor, Sartelli, Massimo, editor, Bassetti, Matteo, editor, and Martin-Loeches, Ignacio, editor
Published: 2018
Full Text: View/download PDF

8. Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016-2017

Author: van Schalkwyk, Erika, Mpembe, Ruth S., Thomas, Juno, Shuping, Liliwe, Ismail, Husna, Lowman, Warren, Karstaedt, Alan S., Chibabhai, Vindana, Wadula, Jeannette, Avenant, Theunis, Messina, Angeliki, Govind, Chetna N., Moodley, Krishnee, Dawood, Halima, Ramjathan, Praksha, and Govender, Nelesh P.
Subjects: Mycoses -- Health aspects -- Comparative analysis, Antifungal agents -- Health aspects -- Comparative analysis, Mass spectrometry -- Health aspects -- Comparative analysis, Infection -- Health aspects -- Comparative analysis, Intelligence gathering, Spectroscopy, Health
Abstract: Since 2009, when the first case of Candida auris infection was identified in South Africa, the number of laboratory-confirmed cases has increased exponentially (1). This multidrug-resistant fungal pathogen emerged worldwide, [...]
Published: 2019
Full Text: View/download PDF

9. Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae : Results From the INCREMENT Cohort

Author: Spanish Network for Research in Infectious Diseases (REIPI)/European Study Group of Bloodstream Infections and Sepsis (ESGBIS)/INCREMENT Group, Palacios-Baena, Zaira Raquel, Gutiérrez-Gutiérrez, Belén, Calbo, Esther, Almirante, Benito, Viale, Pierluigi, Oliver, Antonio, Pintado, Vicente, Gasch, Oriol, Martínez-Martínez, Luis, Pitout, Johann, Akova, Murat, Peña, Carmen, Gil-Bermejo, José Molina, Hernández, Alicia, Venditti, Mario, Prim, Nuria, Bou, German, Tacconelli, Evelina, Tumbarello, Mario, Hamprecht, Axel, Giamarellou, Helen, Almela, Manel, Pérez, Federico, Schwaber, Mitchell J., Bermejo, Joaquín, Lowman, Warren, Hsueh, Po-Ren, Paño-Pardo, José Ramón, Torre-Cisneros, Julián, Souli, Maria, Bonomo, Robert A., Carmeli, Yehuda, Paterson, David L., Pascual, Álvaro, and Rodríguez-Baño, Jesús
Published: 2017

10. Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

Author: del Toro, M D, Gálvez, J, Falcone, M, Russo, A, Giamarellou, H, Trecarichi, E M, Losito, A R, García-Vázquez, E, Hernández, A, Gómez, J, Bou, G, Iosifidis, E, Prim, N, Navarro, F, Mirelis, B, Skiada, A, Origüen, J, Juan, R San, Fernández-Ruiz, M, Larrosa, N, Puig-Asensio, M, Cisneros, J M, Molina, J, González, V, Rucci, V, de Gopegui, E Ruiz, Marinescu, C I, Martínez-Martínez, L, Fariñas, M C, Cano, M E, Gozalo, M, Mora-Rillo, M, Francisco, C Navarro-San, Peña, C, Gómez-Zorrilla, S, Tubau, F, Tsakris, A, Zarkotou, O, Antoniadou, A, Poulakou, G, Pitout, J, Virmani, D, Torre-Cisneros, J, Guzmán-Puche, J, Helvaci, Ö, Sahin, A O, Pintado, V, Ruiz, P, Bartoletti, M, Giannella, M, Tacconelli, E, Riemenschneider, F, Calbo, E, Badia, C, Xercavins, M, Gasch, O, Fontanals, D, Jové, E, Gutiérrez-Gutiérrez, Belén, Salamanca, Elena, de Cueto, Marina, Hsueh, Po-Ren, Viale, Pierluigi, Paño-Pardo, José Ramón, Venditti, Mario, Tumbarello, Mario, Daikos, George, Cantón, Rafael, Doi, Yohei, Tuon, Felipe Francisco, Karaiskos, Ilias, Pérez-Nadales, Elena, Schwaber, Mitchell J, Azap, Özlem Kurt, Souli, Maria, Roilides, Emmanuel, Pournaras, Spyros, Akova, Murat, Pérez, Federico, Bermejo, Joaquín, Oliver, Antonio, Almela, Manel, Lowman, Warren, Almirante, Benito, Bonomo, Robert A, Carmeli, Yehuda, Paterson, David L, Pascual, Alvaro, and Rodríguez-Baño, Jesús
Published: 2017
Full Text: View/download PDF

11. Impact of prior cryptococcal antigen screening on in-hospital mortality in cryptococcal meningitis or fungemia among HIV-seropositive individuals in South Africa: a cross-sectional observational study

Author: Paccoud, Olivier, primary, Shuping, Liliwe, additional, Mashau, Rudzani, additional, Greene, Greg, additional, Quan, Vanessa, additional, Meiring, Susan, additional, Govender, Nelesh P., additional, Abrahams, Shareef, additional, Ahmed, Khatija, additional, Avenant, Theunis, additional, Bamford, Colleen, additional, Bhola, Prathna, additional, Bishop, Kate, additional, Black, John, additional, Blumberg, Lucille, additional, Bosman, Norma, additional, Botha, Maria, additional, Brink, Adrian, additional, Budavari, Suzy, additional, Burra, Asmeeta, additional, Chibabhai, Vindana, additional, Chomba, Rispah, additional, Cohen, Cheryl, additional, Coovadia, Yacoob, additional, Crowther-Gibson, Penny, additional, Dawood, Halima, additional, de Gouveia, Linda, additional, Dlamini, Nomonde, additional, Dlamini, Siyanda, additional, Dreyer, Andries, additional, du Plessis, Nicolette, additional, du Plessis, Erna, additional, du Plessis, Mignon, additional, Erasmus, Linda, additional, Feldman, Charles, additional, Govender, Nelesh, additional, Govind, Chetna, additional, Groome, Michelle, additional, Haffejee, Sumayya, additional, Hamese, Ken, additional, Haumann, Carel, additional, Hoho, Nombulelo, additional, Hoosen, Anwar, additional, Hoosien, Ebrahim, additional, Howell, Victoria, additional, Hoyland, Greta, additional, Ismail, Farzana, additional, Ismail, Husna, additional, Ismail, Nazir, additional, Ive, Prudence, additional, Jooste, Pieter, additional, Karstaedt, Alan, additional, Khantsi, Ignatius, additional, Kleinhans, Vicky, additional, Kleynhans, Jackie, additional, Kolojane, Molebogeng, additional, Kufa-Chakezha, Tendesayi, additional, Lebaka, Tiisetso, additional, Lebudi, Jacob, additional, Legare, Neo, additional, Lekalakala, Ruth, additional, Lindeque, Kathy, additional, Lowman, Warren, additional, Madhi, Shabir, additional, Magobo, Rindidzani, additional, Mahabeer, Prasha, additional, Maharaj, Adhil, additional, Makgoba, Martha, additional, Maloba, Molatji, additional, Maluleka, Caroline, additional, Manaka, Mokupi, additional, Mangena, Phetho, additional, Maningi, Nontuthuko, additional, Marcus, Louis, additional, Marshall, Terry, additional, Mathebula, Rudzani, additional, Mathunjwa, Azwifarwi, additional, Mbelle, Nontombi, additional, Mbuthu, Bongani, additional, McCarthy, Kerrigan, additional, Mekgoe, Omphile, additional, Menezes, Colin, additional, Miller, Cecilia, additional, Mlisana, Koleka, additional, Moncho, Masego, additional, Moore, David, additional, Moremi, Myra, additional, Morris, Lynn, additional, Moshe, Moamokgethi, additional, Mothibi, Lesego, additional, Moultrie, Harry, additional, Mpembe, Ruth, additional, Mutevedzi, Portia, additional, Mwansa-Kambafwile, Judith, additional, Naby, Fathima, additional, Naicker, Preneshni, additional, Naidoo, Romola, additional, Nana, Trusha, additional, Nchabeleng, Maphoshane, additional, Ndlovu, Phathutshedzo, additional, Nel, Jeremy, additional, Ngomane, Mimmy, additional, Ngubane, Wendy, additional, Nicol, Mark, additional, Njikho, Sunnieboy, additional, Ntlemo, Grace, additional, Ntuli, Sindi, additional, Page, Nicola, additional, Paulse, Nuraan, additional, Pearce, Vanessa, additional, Perovic, Olga, additional, Pillay, Keshree, additional, Pombo, Dina, additional, Poswa, Xoliswa, additional, Prentice, Elizabeth, additional, Puren, Adrian, additional, Ramjathan, Praksha, additional, Ramkillawan, Yeishna, additional, Reddy, Kessendri, additional, Reubenson, Gary, additional, Richards, Lauren, additional, Said, Mohammed, additional, Samodien, Nazlee, additional, Samuel, Catherine, additional, Seetharam, Sharona, additional, Sekwadi, Phuti, additional, Selekisho, Mirriam, additional, Senekal, Marthinus, additional, Sibiya, Ngoaka, additional, Sirkar, Surendra, additional, Smit, Juanita, additional, Smith, Anthony, additional, Smith, Marshagne, additional, Sookan, Lisha, additional, Sriruttan, Charlotte, additional, Stacey, Sarah, additional, Swe Han, Khine Swe, additional, Thomas, Teena, additional, Thomas, Juno, additional, Tsisti, Merika, additional, van Schalkwyk, Erika, additional, Variava, Ebrahim, additional, Vazi, Phumeza, additional, Verwey, Charl, additional, von Gottberg, Anne, additional, Wadula, Jeanntte, additional, Walaza, Sibongile, additional, Wende, Linda, additional, Whitelaw, Andrew, additional, Wilson, Douglas, additional, and Zietsman, Inge, additional
Published: 2023
Full Text: View/download PDF

12. Efficacy of ceftazidime-avibactam in solid organ transplant recipients with bloodstream infections caused by carbapenemase-producing Klebsiella pneumoniae

Author: Pérez-Nadales, Elena, primary, Fernández-Ruiz, Mario, additional, Natera, Alejandra M., additional, Gutiérrez-Gutiérrez, Belén, additional, Mularoni, Alessandra, additional, Russelli, Giovanna, additional, Camera Pierrotti, Ligia, additional, Pinheiro Freire, Maristela, additional, Falcone, Marco, additional, Tiseo, Giusy, additional, Tumbarello, Mario, additional, Raffaelli, Francesca, additional, Abdala, Edson, additional, Bodro, Marta, additional, Gervasi, Elena, additional, Fariñas, María Carmen, additional, Seminari, Elena M., additional, Castón, Juan José, additional, Marín-Sanz, Juan Antonio, additional, Gálvez-Soto, Víctor, additional, Rana, Meenakshi M., additional, Loeches, Belén, additional, Martín-Dávila, Pilar, additional, Pascual, Álvaro, additional, Rodríguez-Baño, Jesús, additional, Aguado, José María, additional, Martínez-Martínez, Luis, additional, Torre-Cisneros, Julián, additional, Paul, Mical, additional, Carratala, Jordi, additional, Oriol, Isabel, additional, Rodríguez-Álvarez, Regino José, additional, Cordero, Elisa, additional, Lepe, José Antonio, additional, de Lucas, Esperanza Merino, additional, Muñoz, Patricia, additional, Fortún, Jesús, additional, Coussement, Julien, additional, Dewispelaere, Laurent, additional, Eriksson, Britt Marie, additional, van Delden, Christian, additional, Manuel, Oriol, additional, Clemente, Wanessa T., additional, Strabelli, Tania Mara Varejão, additional, Pilmis, Benoit, additional, Roilides, Emmanuel, additional, Ranganathan N, Iyer, additional, Grossi, Paolo A., additional, Soldani, Fabio, additional, Rizzi, Marco, additional, Tan, Ban Hock, additional, Lowman, Warren, additional, Gunseren, Filiz, additional, Arslan, Hande, additional, Tufan, Zeliha Koçak, additional, Kazak, Esra, additional, David, Miruna D., additional, Steinke, Seema Mehta, additional, Ostrander, Darin, additional, Avery, Robin, additional, and Lease, Erika D., additional
Published: 2023
Full Text: View/download PDF

13. A Predictive Model of Mortality in Patients With Bloodstream Infections due to Carbapenemase-Producing Enterobacteriaceae

Author: Gálvez, J., Falcone, M., Russo, A., Giamarellou, H., Trecarichi, E.M., Losito, A.R., García-Vázquez, E., Hernández, A., Gómez, J., Iosifidis, E., Prim, N., Navarro, F., Mirelis, B., Origüen, J., San Juan, R., Fernández-Ruiz, M., Larrosa, N., Puig-Asensio, M., Cisneros, J.M., Molina, J., González, V., Rucci, V., Ruiz de Gopegui, E., Marinescu, C.I., Martínez-Martínez, L., Fariñas, M.C., Cano, M.E., Gozalo, M., Mora-Rillo, M., Navarro-San Francisco, C., Peña, C., Gómez-Zorrilla, S., Tubau, F., Tsakris, A., Zarkotou, O., Azap, Ö.K., Pitout, J., Virmani, D., Torre-Cisneros, J., Natera, C., Helvaci, Ö., Sahin, A.O., Cantón, R., Ruiz, P., Bartoletti, M., Giannella, M., Taconelli, E., Riemenschneider, F., Calbo, E., Badia, C., Xercavins, M., Gasch, E., Fontanals, D., Jové, E., Gutiérrez-Gutiérrez, Belén, Salamanca, Elena, de Cueto, Marina, Hsueh, Po-Ren, Viale, Pierluigi, Paño-Pardo, José Ramón, Venditti, Mario, Tumbarello, Mario, Daikos, George, Pintado, Vicente, Doi, Yohei, Tuon, Felipe Francisco, Karaiskos, Ilias, Machuca, Isabel, Schwaber, Mitchell J., Azap, Özlem Kurt, Souli, Maria, Roilides, Emmanuel, Pournaras, Spyros, Akova, Murat, Pérez, Federico, Bermejo, Joaquín, Oliver, Antonio, Almela, Manel, Lowman, Warren, Almirante, Benito, Bonomo, Robert A., Carmeli, Yehuda, Paterson, David L., Pascual, Alvaro, and Rodríguez-Baño, Jesús
Published: 2016
Full Text: View/download PDF

14. Clinical application of Vitek-derived minimum inhibitory concentration values: Proof of concept study

Author: Lowman, Warren, primary
Published: 2023
Full Text: View/download PDF

15. Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review

Author: Chibabhai, Vindana, Nana, Trusha, Bosman, Norma, Thomas, Teena, and Lowman, Warren
Published: 2017
Full Text: View/download PDF

16. Best practices: Appropriate use of the new β-lactam/β-lactamase inhibitor combinations, ceftazidime-avibactam and ceftolozane-tazobactam in South Africa

Author: Brink, Adrian J., primary, Coetzee, Jennifer, additional, Richards, Guy A., additional, Feldman, Charles, additional, Lowman, Warren, additional, Tootla, Hafsah D., additional, Miller, Malcolm G.A., additional, Niehaus, Abraham J., additional, Wasserman, Sean, additional, Perovic, Olga, additional, Govind, Chetna N., additional, Schellack, Natalie, additional, and Mendelson, Marc, additional
Published: 2022
Full Text: View/download PDF

17. The Value and Interpretation of Microbiological Specimens in the Management of cIAI

Author: Lowman, Warren, primary
Published: 2017
Full Text: View/download PDF

18. In vitro activity of ceftazidime-avibactam against clinical isolates of Enterobacteralesand Pseudomonas aeruginosafrom sub-Saharan Africa: ATLAS Global Surveillance Program 2017–2021

Author: Wise, Mark G., Karlowsky, James A., Hackel, Meredith A., Harti, Mohamed Amine, Ntshole, Bontle M.E., Njagua, Eva Njeri, Oladele, Rita, Samuel, Catherine, Khan, Shameema, Wadula, Jeannette, Lowman, Warren, Lembede, Busisani W., and Sahm, Daniel F.
Abstract: •96.2% of all Enterobacterales isolates were ceftazidime-avibactam-susceptible.•Most ceftazidime-avibactam-resistant Enterobacterales isolates carried MBL genes.•88.9% of all Pseudomonas aeruginosaisolates were ceftazidime-avibactam-susceptible.•43.1% of ceftazidime-avibactam-resistant P. aeruginosaisolates carried MBL genes.•4.4% of Enterobacterales and 8.9% of P. aeruginosaisolates had a DTR phenotype.
Published: 2023
Full Text: View/download PDF

19. Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study

Author: Mashau, Rudzani C, primary, Meiring, Susan T, additional, Quan, Vanessa C, additional, Nel, Jeremy, additional, Greene, Greg S, additional, Garcia, Andrea, additional, Menezes, Colin, additional, Reddy, Denasha L, additional, Venter, Michelle, additional, Stacey, Sarah, additional, Madua, Matamela, additional, Boretti, Lia, additional, Harrison, Thomas S, additional, Meintjes, Graeme, additional, Shroufi, Amir, additional, Trivino-Duran, Laura, additional, Black, John, additional, Govender, Nelesh P, additional, Abrahams, Shareef, additional, Pearce, Vanessa, additional, Moncho, Masego, additional, Wadula, Jeanette, additional, Maloba, Motlatji, additional, Hoosen, Anwar, additional, Verwey, Charl, additional, Moore, David, additional, Pombo, Dina, additional, Reubenson, Gary, additional, Ntlemo, Grace, additional, Richards, Lauren, additional, Nchabeleng, Maphoshane, additional, Tsitsi, Merika, additional, Moshe, Moamokgethi, additional, Said, Mohammed, additional, Kolojane, Molebogeng, additional, Mothibi, Lesego, additional, Du Plessis, Nicolette, additional, Chomba, Rispah, additional, Thomas, Teena, additional, Avenant, Theunis, additional, Nana, Trusha, additional, Chibabhai, Vindana, additional, Maharj, Adhil, additional, Wilson, Douglas, additional, Naby, Fathima, additional, Dawood, Halima, additional, Han, Khine Swe Swe, additional, Sookan, Lisha, additional, Dlamini, Nomonde, additional, Ramajathan, Praksha, additional, Mahabeer, Prasha, additional, Bhola, Prathna, additional, Naidoo, Romola, additional, Haffejee, Sumayya, additional, Sirkar, Surendra, additional, Ramkillawan, Yeishna, additional, Hamese, Ken, additional, Sibiya, Ngoaka, additional, Mangena, Phetho, additional, Lekalakala, Ruth, additional, Hoyland, Greta, additional, Ntuli, Sindi, additional, Variava, Ebrahim, additional, Khantsi, Ignatius, additional, Mekgoe, Omphile, additional, Brink, Adrian, additional, Prentice, Elizabeth, additional, Reddy, Kessendri, additional, Whitelaw, Andrew, additional, Hoosien, Ebrahim, additional, Zietsman, Inge, additional, Marshall, Terry, additional, Poswa, Xoliswa, additional, Govind, Chetna, additional, Smit, Juanita, additional, Pillay, Keshree, additional, Seetharam, Sharona, additional, Howell, Victoria, additional, Samuel, Catherine, additional, Senekal, Marthinus, additional, Bamford, Colleen, additional, Dreyer, Andries, additional, Marcus, Louis, additional, Lowman, Warren, additional, von Gottberg, Anne, additional, Smith, Anthony, additional, Mathunjwa, Azwifarwi, additional, d'Abreu, Cecilia, additional, Miller, Cecilia, additional, Cohen, Cheryl, additional, Ismail, Farzana, additional, Moultrie, Harry, additional, Ismail, Husna, additional, Weyer, Jacqueline, additional, Kleynhans, Jackie, additional, Rossouw, Jenny, additional, Frean, John, additional, Ebonwu, Joy, additional, Mwansa-Kambafwile, Judith, additional, Thomas, Juno, additional, Bishop, Kate, additional, McCarthy, Kerrigan, additional, Shuping, Liliwe, additional, de Gouveia, Linda, additional, Erasmus, Linda, additional, Puren, Adrian, additional, Blumberg, Lucille, additional, Smith, Marshagne, additional, Makgoba, Martha, additional, Groome, Michelle, additional, du Plessis, Mignon, additional, Ngomane, Mimmy, additional, Manaka, Mokupi, additional, Moremi, Myra, additional, Ismail, Nazir, additional, Legare, Neo, additional, Page, Nicola, additional, Hoho, Nombulelo, additional, Perovic, Olga, additional, Sekwadi, Phuti, additional, Magobo, Rindidzani, additional, Mpembe, Ruth, additional, Walaza, Sibongile, additional, Dlamini, Siyanda, additional, Njikho, Sunnieboy, additional, Lebaka, Tiisetso, additional, and Ngubane, Wendy, additional
Published: 2022
Full Text: View/download PDF

20. Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa

Author: Lowe, Michelle, primary, Singh-Moodley, Ashika, additional, Ismail, Husna, additional, Thomas, Teena, additional, Chibabhai, Vindana, additional, Nana, Trusha, additional, Lowman, Warren, additional, Ismail, Arshad, additional, Chan, Wai Yin, additional, and Perovic, Olga, additional
Published: 2022
Full Text: View/download PDF

21. Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extended-spectrum-β-lactamase-producing Enterobacteriaceae

Author: Palacios-Baena, Zaira Raquel, Gutiérrez-Gutiérrez, Belén, De Cueto, Marina, Viale, Pierluigi, Venditti, Mario, Hernández-Torres, Alicia, Oliver, Antonio, Martínez-Martínez, Luis, Calbo, Esther, Pintado, Vicente, Gasch, Oriol, Almirante, Benito, Antonio Lepe, José, Pitout, Johann, Akova, Murat, Peña-Miralles, Carmen, Schwaber, Mitchell J., Tumbarello, Mario, Tacconelli, Evelina, Origüen, Julia, Prim, Nuria, Bou, German, Giamarellou, Helen, Bermejo, Joaquín, Hamprecht, Axel, Pérez, Federico, Almela, Manuel, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Torre-Cisneros, Julián, Carmeli, Yehuda, Bonomo, Robert A., Paterson, David L., Pascual, Álvaro, and Rodríguez-Baño, Jesús
Published: 2017
Full Text: View/download PDF

22. The novel application and effect of an ultraviolet light decontamination strategy on the healthcare acquisition of carbapenem-resistant Enterobacterales in a hospital setting

Author: Lowman, Warren, primary, Etheredge, Harriet R., additional, Gaylard, Petra, additional, and Fabian, June, additional
Published: 2021
Full Text: View/download PDF

23. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients

Author: Gutierrez-Gutierrez, Belen, Perez-Nadales, Elena, Perez-Galera, Salvador, Fernandez-Ruiz, Mario, Carratala, Jordi, Oriol, Isabel, Cordero, Elisa, Antonio Lepe, Jose, Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Pierrotti, Ligia Camera, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Munoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena Maria, Gunseren, Filiz, Lease, Erika D., Roilides, Emmanuel, Fortun, Jesus, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Kocak, Pilmis, Benoit, Rizzi, Marco, Loeches, Belen, Eriksson, Britt-Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa Trindade, Bodro, Marta, Carmen Farinas, Maria, Kazak, Esra, Martinez-Martinez, Luis, Maria Aguado, Jose, Torre-Cisneros, Julian, Pascual, Alvaro, Rodriguez-Bano, Jesus, Gutierrez-Gutierrez, Belen, Perez-Nadales, Elena, Perez-Galera, Salvador, Fernandez-Ruiz, Mario, Carratala, Jordi, Oriol, Isabel, Cordero, Elisa, Antonio Lepe, Jose, Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Pierrotti, Ligia Camera, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Munoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena Maria, Gunseren, Filiz, Lease, Erika D., Roilides, Emmanuel, Fortun, Jesus, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Kocak, Pilmis, Benoit, Rizzi, Marco, Loeches, Belen, Eriksson, Britt-Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa Trindade, Bodro, Marta, Carmen Farinas, Maria, Kazak, Esra, Martinez-Martinez, Luis, Maria Aguado, Jose, Torre-Cisneros, Julian, Pascual, Alvaro, and Rodriguez-Bano, Jesus
Abstract: There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages.
Published: 2021
Full Text: View/download PDF

24. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients

Author: Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Sociedad Andaluza de Trasplante de Órganos y Tejidos, Ministerio de Ciencia e Innovación (España), Gutiérrez-Gutiérrez, Belén, Pérez-Nadales, Elena, Pérez-Galera, Salvador, Fernández-Ruiz, Mario, Carratalà, Jordi, Oriol, Isabel, Cordero-Matía, Elisa, Lepe, José A., Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Camera Pierrotti, Ligia, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Muñoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena María, Gunseren, Filiz, Lease, Erika D., Fortún, Emmanuel, Roilides, Jesús, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Koçak, Pilmis, Benoît, Rizzi, Marco, Loeches, Belén, Eriksson, Britt Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa T., Bodro, Marta, Fariñas, María del Carmen, Kazak, Esra, Martínez-Martínez, Luis, Aguado, José María, Torre-Cisneros, Julián, Pascual, Álvaro, Rodríguez-Baño, Jesús, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Sociedad Andaluza de Trasplante de Órganos y Tejidos, Ministerio de Ciencia e Innovación (España), Gutiérrez-Gutiérrez, Belén, Pérez-Nadales, Elena, Pérez-Galera, Salvador, Fernández-Ruiz, Mario, Carratalà, Jordi, Oriol, Isabel, Cordero-Matía, Elisa, Lepe, José A., Tan, Ban Hock, Corbella, Laura, Paul, Mical, Natera, Alejandra M., David, Miruna D., Montejo, Miguel, Iyer, Ranganathan N., Camera Pierrotti, Ligia, Merino, Esperanza, Steinke, Seema Mehta, Rana, Meenakshi M., Muñoz, Patricia, Mularoni, Alessandra, van Delden, Christian, Grossi, Paolo Antonio, Seminari, Elena María, Gunseren, Filiz, Lease, Erika D., Fortún, Emmanuel, Roilides, Jesús, Arslan, Hande, Coussement, Julien, Tufan, Zeliha Koçak, Pilmis, Benoît, Rizzi, Marco, Loeches, Belén, Eriksson, Britt Marie, Abdala, Edson, Soldani, Fabio, Lowman, Warren, Clemente, Wanessa T., Bodro, Marta, Fariñas, María del Carmen, Kazak, Esra, Martínez-Martínez, Luis, Aguado, José María, Torre-Cisneros, Julián, Pascual, Álvaro, and Rodríguez-Baño, Jesús
Abstract: There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages.
Published: 2021

25. Warren Lowman WJCM webinar June 2020.pdf

Author: Lowman, Warren
Abstract: Dr Warren Lowman - Pathologist, Clinical Microbiology & Infectious Diseases, School of Pathology, University of the Witwatersrand, Johannesburg. (https://orcid.org/0000-0002-6981-389X)
Published: 2020
Full Text: View/download PDF

26. Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia

Author: European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M., Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N., Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, Costa-Mateo, Jose M., Rana, Meenakshi M., Mara Varejao Strabelli, Tania, Paul, Mical, Fariñas, María del Carmen, Trindade Clemente, Wanessa, Roilides, Emmanuel, Muñoz García, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Grossi, Paolo Antonio, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Luis, Aguado, José María, Torre-Cisneros, Julián, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M., Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N., Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, Costa-Mateo, Jose M., Rana, Meenakshi M., Mara Varejao Strabelli, Tania, Paul, Mical, Fariñas, María del Carmen, Trindade Clemente, Wanessa, Roilides, Emmanuel, Muñoz García, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Grossi, Paolo Antonio, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Luis, Aguado, José María, and Torre-Cisneros, Julián
Abstract: Treatment of carbapenemase‐producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase‐producing Enterobacterales bloodstream infections. A multinational, retrospective (2004‐2016) cohort study (INCREMENT‐SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30‐day all‐cause mortality. The INCREMENT‐SOT‐CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT‐CPE mortality score ≥8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT‐CPE score ≥8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76‐0.88) and classified patients into 3 strata: 0‐7 (low mortality), 8‐11 (high mortality), and 12‐17 (very‐high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very‐high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13‐7.06, P = .03) and high (HR 9.93, 95% CI 2.08‐47.40, P = .004) mortality risk strata. A score‐based algorithm is provided for therapy guidance.
Published: 2020

27. Influence of COVID-19 Pandemic on Health-care Workers’ Hand Hygiene Practice at a Private Academic Hospital in Johannesburg, South Africa: A Quantitative and Qualitative Longitudinal Study

Author: Watkins, Estella L., primary, Sibiya, Zama, additional, Bizos, Damon, additional, and Lowman, Warren, additional
Published: 2021
Full Text: View/download PDF

28. South African Society of Clinical Microbiology Clostridioides difficile infection diagnosis, management and infection prevention and control guideline

Author: Nana, Trusha, primary, Moore, Chanelle, additional, Boyles, Tom, additional, Brink, Adrian J., additional, Cleghorn, Joy, additional, Devenish, Lesley M., additional, du Toit, Briette, additional, Fredericks, Ernst S., additional, Lekalakala-Mokaba, Molebogeng R., additional, Maluleka, Caroline, additional, Rajabally, Muhammad N., additional, Reubenson, Gary, additional, Shuping, Liliwe, additional, Swart, Karin, additional, Swe Han, Khine Swe, additional, Wadula, Jeannette, additional, Wojno, Justyna, additional, and Lowman, Warren, additional
Published: 2020
Full Text: View/download PDF

29. Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa

Author: Chiba, Sheetal, primary, Lowman, Warren, additional, and Schleicher, Gunter, additional
Published: 2020
Full Text: View/download PDF

30. Best practices: Appropriate use of the new β-lactam/ β-lactamase inhibitor combinations, ceftazidimeavibactam and ceftolozane-tazobactam in South Africa.

Author: Brink, Adrian J., Coetzee, ennifer, Richards, Guy A., Feldman, Charles, Lowman, Warren, Tootla, Hafsah D., Miller, Malcolm G.A., Niehaus, Abraham J., Wasserman, Sean, Perovic, Olga, Govind, Chetna N., Schellack, Natalie, and Mendelson, Marc
Abstract: Antibiotic stewardship of hospital-acquired infections because of difficult-to-treat resistant (DTR) Gram-negative bacteria is a global challenge. Their increasing prevalence in South Africa has required a shift in prescribing in recent years towards colistin, an antibiotic of last resort. High toxicity levels and developing resistance to colistin are narrowing treatment options further. Recently, two new β-lactam/β-lactamase inhibitor combinations, ceftazidime-avibactam and ceftolozane-tazobactam were registered in South Africa, bringing hope of new options for management of these life-threatening infections. However, with increased use in the private sector, increasing levels of resistance to ceftazidimeavibactam are already being witnessed, putting their long-term viability as treatment options of last resort, in jeopardy. This review focuses on how these two vital new antibiotics should be stewarded within a framework that recognises the resistance mechanisms currently predominant in South Africa’s multi-drug and DTR Gram-negative bacteria. Moreover, the withholding of their use for resistant infections that can be treated with currently available antibiotics is a critical part of stewardship, if these antibiotics are to be conserved in the long term. [ABSTRACT FROM AUTHOR]
Published: 2022
Full Text: View/download PDF

31. A case of community-acquired Acinetobacter baumannii meningitis – has the threat moved beyond the hospital?

Author: Lowman, Warren, Kalk, Thomas, Menezes, Colin N., John, Melanie A., and Grobusch, Martin P.
Published: 2008
Full Text: View/download PDF

32. Predictors of mortality in solid organ transplant recipients with bloodstream infections due to carbapenemase-producing Enterobacterales: The impact of cytomegalovirus disease and lymphopenia

Author: Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M, Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N, Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, María Costa-Mateo, José, Rana, Meenakshi M, Mara Varejão Strabelli, Tania, Paul, Mical, Carmen Fariñas, María, Trindade Clemente, Wanessa, Roilides, Emmanuel, Muñoz, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Antonio Grossi, Paolo, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Lui, María Aguado, José, Rodríguez-Baño, Jesú, Torre-Cisneros, Julián, Tumbarello, Mario (ORCID:0000-0002-9519-8552), Pérez-Nadales, Elena, Gutiérrez-Gutiérrez, Belén, Natera, Alejandra M, Abdala, Edson, Reina Magalhães, Maira, Mularoni, Alessandra, Monaco, Francesco, Camera Pierrotti, Ligia, Pinheiro Freire, Maristela, Iyer, Ranganathan N, Mehta Steinke, Seema, Grazia Calvi, Elisa, Tumbarello, Mario, Falcone, Marco, Fernández-Ruiz, Mario, María Costa-Mateo, José, Rana, Meenakshi M, Mara Varejão Strabelli, Tania, Paul, Mical, Carmen Fariñas, María, Trindade Clemente, Wanessa, Roilides, Emmanuel, Muñoz, Patricia, Dewispelaere, Laurent, Loeches, Belén, Lowman, Warren, Hock Tan, Ban, Escudero-Sánchez, Rosa, Bodro, Marta, Antonio Grossi, Paolo, Soldani, Fabio, Gunseren, Filiz, Nestorova, Nina, Pascual, Álvaro, Martínez-Martínez, Lui, María Aguado, José, Rodríguez-Baño, Jesú, Torre-Cisneros, Julián, and Tumbarello, Mario (ORCID:0000-0002-9519-8552)
Abstract: Treatment of carbapenemase-producing Enterobacterales bloodstream infections in solid organ transplant recipients is challenging. The objective of this study was to develop a specific score to predict mortality in solid organ transplant recipients with carbapenemase-producing Enterobacterales bloodstream infections. A multinational, retrospective (2004-2016) cohort study (INCREMENT-SOT, ClinicalTrials.gov NCT02852902) was performed. The main outcome variable was 30-day all-cause mortality. The INCREMENT-SOT-CPE score was developed using logistic regression. The global cohort included 216 patients. The final logistic regression model included the following variables: INCREMENT-CPE mortality score ≥8 (8 points), no source control (3 points), inappropriate empirical therapy (2 points), cytomegalovirus disease (7 points), lymphopenia (4 points), and the interaction between INCREMENT-CPE score ≥8 and CMV disease (minus 7 points). This score showed an area under the receiver operating characteristic curve of 0.82 (95% confidence interval [CI] 0.76-0.88) and classified patients into 3 strata: 0-7 (low mortality), 8-11 (high mortality), and 12-17 (very-high mortality). We performed a stratified analysis of the effect of monotherapy vs combination therapy among 165 patients who received appropriate therapy. Monotherapy was associated with higher mortality only in the very-high (adjusted hazard ratio [HR] 2.82, 95% CI 1.13-7.06, P = .03) and high (HR 9.93, 95% CI 2.08-47.40, P = .004) mortality risk strata. A score-based algorithm is provided for therapy guidance.
Published: 2019

33. EditorialMinimum inhibitory concentration-guided antimicrobial therapy – the Achilles heel in the antimicrobial stewardship agenda

Author: Lowman, Warren
Abstract: Click on the link to view.Afr Med J 2018;108(9):710-712
Published: 2018

34. Procalcitonin-guided antibiotic therapy for suspected and confirmed sepsis of patients in a surgical-trauma ICU: a prospective, two-period cross-over, interventional study

Author: Chomba, Rispah, primary, Moeng, Maeyane Steve, additional, and Lowman, Warren, additional
Published: 2019
Full Text: View/download PDF

35. Federation of Infectious Diseases Societies of Southern Africa guideline: Recommendations for the detection, management and prevention of healthcare-associated Candida auris colonisation and disease in South Africa

Author: Govender, Nelesh P., primary, Avenant, Theunis, additional, Brink, Adrian, additional, Chibabhai, Vindana, additional, Cleghorn, Joy, additional, du Toit, Briette, additional, Govind, Chetna, additional, Lewis, Elsie, additional, Lowman, Warren, additional, Mahlangu, Hleziphi, additional, Maslo, Caroline, additional, Messina, Angeliki, additional, Mer, Mervyn, additional, Pieton, Kim, additional, Seetharam, Sharona, additional, Sriruttan, Charlotte, additional, Swart, Karin, additional, and van Schalkwyk, Erika, additional
Published: 2019
Full Text: View/download PDF

36. Comparison of Predictors and Mortality Between Bloodstream Infections Caused by ESBL-Producing Escherichia coli and ESBL-Producing Klebsiella pneumoniae

Author: Scheuerman, Oded, Schechner, Vered, Carmeli, Yehuda, Gutierrez-Gutierrez, Belen, Calbo, Esther, Almirante, Benito, Viale, Pier-Luigy, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Gasch, Oriol, Gozalo, Monica, Pitout, Johann, Akova, Murat, Pena, Carmen, Molina, Jose, Hernandez-Torres, Alicia, Venditti, Mario, Prim, Nuria, Origuen, Julia, Bou, German, Tacconelli, Evelina, Tumbarello, Maria, Hamprecht, Axel, Karaiskos, Ilias, de la Calle, Cristina, Perez, Federico, Schwaber, Mitchell J., Bermejo, Joaquin, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Bonomo, Robert A., Paterson, David L., Pascual, Alvaro, Rodriguez-Bano, Jesus, Scheuerman, Oded, Schechner, Vered, Carmeli, Yehuda, Gutierrez-Gutierrez, Belen, Calbo, Esther, Almirante, Benito, Viale, Pier-Luigy, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Gasch, Oriol, Gozalo, Monica, Pitout, Johann, Akova, Murat, Pena, Carmen, Molina, Jose, Hernandez-Torres, Alicia, Venditti, Mario, Prim, Nuria, Origuen, Julia, Bou, German, Tacconelli, Evelina, Tumbarello, Maria, Hamprecht, Axel, Karaiskos, Ilias, de la Calle, Cristina, Perez, Federico, Schwaber, Mitchell J., Bermejo, Joaquin, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Bonomo, Robert A., Paterson, David L., Pascual, Alvaro, and Rodriguez-Bano, Jesus
Abstract: OBJECTIVETo compare the epidemiology, clinical characteristics, and mortality of patients with bloodstream infections (BSI) caused by extended-spectrum -lactamase (ESBL)-producing Escherichia coli (ESBL-EC) versus ESBL-producing Klebsiella pneumoniae (ESBL-KP) and to examine the differences in clinical characteristics and outcome between BSIs caused by isolates with CTX-M versus other ESBL genotypesMETHODSAs part of the INCREMENT project, 33 tertiary hospitals in 12 countries retrospectively collected data on adult patients diagnosed with ESBL-EC BSI or ESBL-KP BSI between 2004 and 2013. Risk factors for ESBL-EC versus ESBL-KP BSI and for 30-day mortality were examined by bivariate analysis followed by multivariable logistic regression.RESULTSThe study included 909 patients: 687 with ESBL-EC BSI and 222 with ESBL-KP BSI. ESBL genotype by polymerase chain reaction amplification of 286 isolates was available. ESBL-KP BSI was associated with intensive care unit admission, cardiovascular and neurological comorbidities, length of stay to bacteremia >14 days from admission, and a nonurinary source. Overall, 30-day mortality was significantly higher in patients with ESBL-KP BSI than ESBL-EC BSI (33.7% vs 17.4%; odds ratio, 1.64; P=.016). CTX-M was the most prevalent ESBL subtype identified (218 of 286 polymerase chain reaction-tested isolates, 76%). No differences in clinical characteristics or in mortality between CTX-M and non-CTX-M ESBLs were detected.CONCLUSIONSClinical characteristics and risk of mortality differ significantly between ESBL-EC and ESBL-KP BSI. Therefore, all ESBL-producing Enterobacteriaceae should not be considered a homogeneous group. No differences in outcomes between genotypes were detected.CLINICAL TRIALS IDENTIFIERClinicalTrials.gov. Identifier: NCT01764490.Infect Control Hosp Epidemiol 2018;39:660-667
Published: 2018

37. Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort

Author: Palacios-Baena, Zaira Raquel, Gutiérrez-Gutiérrez, Belén, Calbo, Esther, Almirante, Benito, Viale, Pierluigi, Oliver, Antonio, Pintado, Vicente, Gasch, Oriol, Martínez-Martínez, Luis, Pitout, Johann, Akova, Murat, Peña, Carmen, Molina Gil-Bermejo, José, Hernández, Alicia, Venditti, Mario, Prim, Nuria, Bou, German, Tacconelli, Evelina, Tumbarello, Mario, Hamprecht, Axel, Giamarellou, Helen, Almela, Manel, Pérez, Federico, Schwaber, Mitchell J, Bermejo, Joaquín, Lowman, Warren, Hsueh, Po-Ren, Paño-Pardo, José Ramón, Torre-Cisneros, Julián, Souli, Maria, Bonomo, Robert A, Carmeli, Yehuda, Paterson, David L, Pascual, Álvaro, and Rodríguez-Baño, Jesús
Subjects: Male, aminoglycosides, therapy, bloodstream infections, Enterobacteriaceae Infections, extended-spectrum β-lactamase–producing Enterobacteriaceae, Bacteremia, Kaplan-Meier Estimate, biochemical phenomena, metabolism, and nutrition, Middle Aged, bacterial infections and mycoses, beta-Lactamases, beta-Lactam Resistance, Anti-Bacterial Agents, Carbapenems, Enterobacteriaceae, polycyclic compounds, bacteria, Humans, Female, antimicrobial resistance, Retrospective Studies
Abstract: There is little information about the efficacy of active alternative drugs to carbapenems except β-lactam/β-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems.
Published: 2017

38. Additional file 1: of The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardshipâ results from an international cross-sectional survey

Author: Sartelli, Massimo, Labricciosa, Francesco, Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian, Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Salomone Di Saverio, May, Addison, Viale, Pierluigi, Watkins, Richard, Scudeller, Luigia, Abbo, Lilian, Abu-Zidan, Fikri, Abdulrashid Adesunkanmi, Al-Dahir, Sara, Al-Hasan, Majdi, Alis, Halil, Alves, Carlos, AndrĂŠ Araujo Da Silva, Augustin, Goran, Miklosh Bala, Barie, Philip, BeltrĂĄn, Marcelo, Bhangu, Aneel, Belefquih Bouchra, Brecher, Stephen, CaĂNzos, Miguel, Camacho-Ortiz, Adrian, Catani, Marco, Sujith Chandy, Asri Jusoh, Cherry-Bukowiec, Jill, Chiara, Osvaldo, Colak, Elif, Cornely, Oliver, Yunfeng Cui, Demetrashvili, Zaza, Simone, Belinda De, Waele, Jan De, Dhingra, Sameer, Marzo, Francesco Di, Dogjani, Agron, Gereltuya Dorj, Dortet, Laurent, Duane, Therese, Elmangory, Mutasim, Mushira Enani, Ferrada, Paula, J. Esteban Foianini, Gachabayov, Mahir, Chinmay Gandhi, Wagih Ghnnam, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen, Rosio Guerra Gronerth, Monteiro, Julio Haidamus, Hardcastle, Timothy, Hecker, Andreas, Hodonou, Adrien, Orestis Ioannidis, Isik, Arda, Iskandar, Katia, Kafil, Hossein, Kanj, Souha, Kaplan, Lewis, Kapoor, Garima, Karamarkovic, Aleksandar, Kenig, Jakub, Kerschaever, Ivan, Faryal Khamis, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong, Wen-Chien Ko, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae, Lee, Young, LeppĂ¤Niemi, Ari, Yousheng Li, Liang, Stephen, Lowman, Warren, Machain, Gustavo, Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Casas, Isidro Martinez, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, Shyam, Moore, Ernest, Akutu Munyika, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica, Nicolau, David, Abdelkarim Omari, Ordonez, Carlos, JosĂŠ-Artur Paiva, Pant, Narayan, Parreira, Jose, PÄDziwiatr, Michal, Pereira, Bruno, Ponce-De-Leon, Alfredo, Garyphallia Poulakou, Preller, Jacobus, CĂŠline Pulcini, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy, Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno, JesĂşs RodrĂGuez-BaĂąo, Sakakushev, Boris, Sanders, James, Santos, Natalia, Sato, Norio, Sawyer, Robert, Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Vishalkumar Shelat, Costi Sifri, Boonying Siribumrungwong, SĂ¸Reide, Kjetil, Soto, Rodolfo, Souza, Hamilton De, Talving, Peep, Ngo Trung, Tessier, Jeffrey, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Goor, Harry Van, Andras Vereczkei, Wagenlehner, Florian, Yonghong Xiao, Kuo-Ching Yuan, Wechsler-FĂśrdĂśs, Agnes, Jean-Ralph Zahar, Zakrison, Tanya, Zuckerbraun, Brian, Zuidema, Wietse, and Catena, Fausto
Abstract: The international cross-sectional survey. (DOC 56 kb)
Published: 2017
Full Text: View/download PDF

39. Candida aurisin South Africa, 2012–2016

Author: Govender, Nelesh P., primary, Magobo, Rindidzani E., additional, Mpembe, Ruth, additional, Mhlanga, Mabatho, additional, Matlapeng, Phelly, additional, Corcoran, Craig, additional, Govind, Chetna, additional, Lowman, Warren, additional, Senekal, Marthinus, additional, and Thomas, Juno, additional
Published: 2018
Full Text: View/download PDF

40. Antimicrobial resistance surveillance in the South African private sector report for 2016

Author: Perovic, Olga, primary, Ismail, Husna, additional, Van Schalkwyk, Erika, additional, Lowman, Warren, additional, Prentice, Elizabeth, additional, Senekal, Marthinus, additional, and Govind, Chetna N., additional
Published: 2018
Full Text: View/download PDF

41. Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extendedspectrum- beta-lactamase-producing Enterobacteriaceae

Author: Raquel Palacios-Baena, Zaira, Gutierrez-Gutierrez, Belen, De Cueto, Marina, Viale, Pierluigi, Venditti, Mario, Hernandez-Torres, Alicia, Oliver, Antonio, Martinez-Martinez, Luis, Calbo, Esther, Pintado, Vicente, Gasch, Oriol, Almirante, Benito, Antonio Lepe, Jose, Pitout, Johann, Akova, Murat, Pena-Miralles, Carmen, Schwaber, Mitchell J., Tumbarello, Mario, Tacconelli, Evelina, Origuen, Julia, Prim, Nuria, Bou, German, Giamarellou, Helen, Bermejo, Joaquin, Hamprecht, Axel, Perez, Federico, Almela, Manuel, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Torre-Cisneros, Julian, Carmeli, Yehuda, Bonomo, Robert A., Paterson, David L., Pascual, Alvaro, Rodriguez-Bano, Jesus, Raquel Palacios-Baena, Zaira, Gutierrez-Gutierrez, Belen, De Cueto, Marina, Viale, Pierluigi, Venditti, Mario, Hernandez-Torres, Alicia, Oliver, Antonio, Martinez-Martinez, Luis, Calbo, Esther, Pintado, Vicente, Gasch, Oriol, Almirante, Benito, Antonio Lepe, Jose, Pitout, Johann, Akova, Murat, Pena-Miralles, Carmen, Schwaber, Mitchell J., Tumbarello, Mario, Tacconelli, Evelina, Origuen, Julia, Prim, Nuria, Bou, German, Giamarellou, Helen, Bermejo, Joaquin, Hamprecht, Axel, Perez, Federico, Almela, Manuel, Lowman, Warren, Hsueh, Po-Ren, Navarro-San Francisco, Carolina, Torre-Cisneros, Julian, Carmeli, Yehuda, Bonomo, Robert A., Paterson, David L., Pascual, Alvaro, and Rodriguez-Bano, Jesus
Abstract: Background. Bloodstream infections (BSIs) due to ESBL-producing Enterobacteriaceae (ESBL-E) are frequent yet outcome prediction rules for clinical use have not been developed. The objective was to define and validate a predictive risk score for 30 day mortality. Methods. A multinational retrospective cohort study including consecutive episodes of BSI due to ESBL-E was performed; cases were randomly assigned to a derivation cohort (DC) or a validation cohort (VC). The main outcome variable was all-cause 30 day mortality. A predictive score was developed using logistic regression coefficients for the DC, then tested in the VC. Results. The DC and VC included 622 and 328 episodes, respectively. The final multivariate logistic regression model for mortality in the DC included age > 50 years (OR = 2.63; 95% CI: 1.18-5.85; 3 points), infection due to Klebsiella spp. (OR = 2.08; 95% CI: 1.21-3.58; 2 points), source other than urinary tract (OR = 3.6; 95% CI: 2.02-6.44; 3 points), fatal underlying disease (OR =3.91; 95% CI: 2.24-6.80; 4 points), Pitt score > 3 (OR =3.04; 95CI: 1.69-5.47; 3 points), severe sepsis or septic shock at presentation (OR = 4.8; 95% CI: 2.72-8.46; 4 points) and inappropriate early targeted therapy (OR = 2.47; 95% CI: 1.58-4.63; 2 points). The score showed an area under the receiver operating curve (AUROC) of 0.85 in the DC and 0.82 in the VC. Mortality rates for patients with scores of < 11 and >= 11 were 5.6% and 45.9%, respectively, in the DC, and 5.4% and 34.8% in the VC. Conclusions. We developed and validated an easy-to-collect predictive scoring model for all-cause 30 day mortality useful for identifying patients at high and low risk of mortality.
Published: 2017

42. The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey

Author: Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K., Viale, Pierluigi, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, FikriM., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlos, Araujo da Silva, Andre R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltran, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Cainzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, ThereseM., Elmangory, Mutasim M., Enani, Mushira A., Ferrada, Paula, Foianini, J. Esteban, Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A., Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andreas, Hodonou, Adrien M., Ioannidis, Orestis, Isik, Arda, Iskandar, Katia A., Kafil, Hossein S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, ShyamK., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, Jose-Artur, Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, BrunoM., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobus, Pulcini, Celine, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodriguez-Bano, Jesus, Sakakushev, Boris, Sanders, James, Santos, Natalia, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying, Soreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andras, Wagenlehner, Floriann, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Foerdoes, Agnes, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, Zuidema, Wietse P., Catena, Fausto, Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K., Viale, Pierluigi, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, FikriM., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlos, Araujo da Silva, Andre R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltran, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Cainzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, ThereseM., Elmangory, Mutasim M., Enani, Mushira A., Ferrada, Paula, Foianini, J. Esteban, Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A., Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andreas, Hodonou, Adrien M., Ioannidis, Orestis, Isik, Arda, Iskandar, Katia A., Kafil, Hossein S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Mishra, ShyamK., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, Jose-Artur, Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, BrunoM., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobus, Pulcini, Celine, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodriguez-Bano, Jesus, Sakakushev, Boris, Sanders, James, Santos, Natalia, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana, Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying, Soreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andras, Wagenlehner, Floriann, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Foerdoes, Agnes, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, Zuidema, Wietse P., and Catena, Fausto
Abstract: Background: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. Methods: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. Results: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p < 0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). Conclusion: T
Published: 2017

43. A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway

Author: Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, Catena, Fausto, Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Carlet, Jean, Brink, Adrian, Hardcastle, Timothy C., Khanna, Ashish, Chicom-Mefire, Alain, Rodriguez-Bano, Jesus, Nathwani, Dilip, Mendelson, Marc, Watkins, Richard R., Pulcini, Celine, Beovic, Bojana, May, Addison K., Itani, Kamal M. F., Mazuski, John E., Fry, Donald E., Coccolini, Federico, Rasa, Kemal, Montravers, Philippe, Eckmann, Christian, Abbo, Lilian M., Abubakar, Salisu, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid Kayode, Al-Hasan, Majdi N., Althani, Asma A., Ticas, Jorge Eduardo Alvarenga, Ansari, Shamshul, Ansumana, Rashid, Araujo da Silva, Andre Ricardo, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussema, Bassett, Matteo, Bellanova, Giovanni, Beltran, Marcelo A., Ben-Ishay, Ofir, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Bueno, Juan, Cainzos, Miguel A., Cairns, Kelly, Camacho-Ortiz, Adrian, Ceresoli, Marco, Chandy, Sujith J., Cherry-Bukowiec, Jill R., Cirocchi, Roberto, Colak, Elif, Corcione, Antonio, Cornely, Oliver A., Cortese, Francesco, Cui, Yunfeng, Curcio, Daniel, Damaskos, Dimitris, Das, Koray, Delibegovic, Samir, Deme-Trashvili, Zaza, De Simone, Belinda, de Souza, Hamilton Petry, De Waele, Jan, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Dupont, Herve, Egiev, Valery N., Eid, Hani O., Elmangory, Mutasim, Marei, Hany El-Sayed, Enani, Mushira Abdulaziz, Escandon-Vargas, Kevin, Faro Junior, Mario P., Ferrada, Paula, Foghetti, Domitilla, Foianini, Esteban, Fraga, Gustavo P., Frattima, Sabrina, Gandhi, Chinmay, Gattuso, Gianni, Giamarellou, Eleni, Ghnnam, Wagih, Gkiokas, George, Girardis, Massimo, Goff, Debbie A., Gomes, Carlos Augusto, Gomi, Harumi, Guerra Gronerth, Rosio Isabel, Guirao, Xavier, Guzman-Blanco, Manuel, Haque, Mainul, Hecker, Andreas, Hell, Markus, Herzog, Torsten, Hicks, Lauri, Kafka-Ritsch, Reinhold, Kao, Lillian S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kashuk, Jeffry, Kenig, Jakub, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kirkpatrick, Andrew W., Korner, Hartwig, Koike, Kaoru, Kok, Kenneth Y. Y., Kon, Kateryna, Kong, Victor, Inaba, Kenji, Ioannidis, Orestis, Isik, Arda, Iskandar, Katia, Labbate, Maurizio, Labricciosa, Francesco M., Lagrou, Katrien, Lagunes, Leonel, Latifi, Rifat, Lasithiotakis, Kostas, Laxminarayan, Ramanan, Lee, Jae Gil, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Liau, Kui-Hin, Litvin, Andrey, Loho, Tonny, Lowman, Warren, Machain, Gustavo M., Maier, Ronald V., Manzano-Nunez, Ramiro, Marinis, Athanasios, Marmorale, Cristina, Martin-Loeches, Ignacio, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael, de Melo, Renato Bessa, Melotti, Maria Rita, Memish, Ziad, Mertz, Dominik, Mesina, Cristian, Menichetti, Francesco, Mishra, Shyam Kumar, Montori, Giulia, Moore, Ernest E., Moore, Frederick A., Naidoo, Noel, Napolitano, Lena, Negoi, Ionut, Nicolau, David P., Nikolopoulos, Ioannis, Nord, Carl Erik, Ofori-Asenso, Richard, Olaoye, Iyiade, Omari, Abdelkarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Ouedraogo, Abdoul-Salam, Pagani, Leonardo, Paiva, Jose Artur, Parreira, Jose Gustavo, Pata, Francesco, Pereira, Jorge, Pereira, Nuno R., Petrosillo, Nicola, Picetti, Edoardo, Pintar, Tadeja, Ponce-de-Leon, Alfredo, Popovski, Zagorka, Poulakou, Garyphallia, Preller, Jacobus, Guerrero, Adrian Puello, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reichert, Martin, Reinhart, Konrad, Rems, Miran, Rello, Jordi, Rizoli, Sandro, Roberts, Jason, Rubio-Perez, Ines, Ruppc, Etienne, Sakakushev, Boris, Sall, Ibrahima, Kafil, Hossein Samadi, Sanders, James, Sato, Norio, Sawyer, Robert G., Scalea, Thomas, Scibe, Rodolfo, Scudeller, Luigia, Segovia Lohse, Helmut, Sganga, Gabriele, Shafiq, Nusrat, Shah, Jay N., Spigaglia, Patrizia, Suroowan, Shanoo, Tsioutis, Constantinos, Sifri, Costi D., Siribumrungwong, Boonying, Sugrue, Michael, Talving, Peep, Tan, Boun Kim, Tarasconi, Antonio, Tascini, Carlo, Tilsed, Jonathan, Timsit, Jean-Francois, Tumbarello, Mario, Ulrych, Jan, Uranues, Selman, Velmahos, George, Vereczkei, Andras G., Viale, Pierluigi, Vila Estape, Jordi, Viscoli, Claudio, Wagenlehner, Florian, Wright, Brian J., Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean Ralph, Mergulhao, Paulo, and Catena, Fausto
Abstract: This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.
Published: 2017

44. Empiric Therapy With Carbapenem-Sparing Regimens for Bloodstream Infections due to Extended-Spectrum beta-Lactamase-Producing Enterobacteriaceae: Results From the INCREMENT Cohort

Author: Raquel Palacios-Baena, Zaira, Gutierrez-Gutierrez, Belen, Calbo, Esther, Almirante, Benito, Viale, Pierluigi, Oliver, Antonio, Pintado, Vicente, Gasch, Oriol, Martinez-Martinez, Luis, Pitout, Johann, Akova, Murat, Pena, Carmen, Molina Gil-Bermejo, Jose, Hernandez, Alicia, Venditti, Mario, Prim, Nuria, Bou, German, Tacconelli, Evelina, Tumbarello, Mario, Hamprecht, Axel, Giamarellou, Helen, Almela, Manel, Perez, Federico, Schwaber, Mitchell J., Bermejo, Joaquin, Lowman, Warren, Hsueh, Po-Ren, Ramon Pano-Pardo, Jose, Torre-Cisneros, Julian, Souli, Maria, Bonomo, Robert A., Carmeli, Yehuda, Paterson, David L., Pascual, Alvaro, Rodriguez-Bano, Jesus, Raquel Palacios-Baena, Zaira, Gutierrez-Gutierrez, Belen, Calbo, Esther, Almirante, Benito, Viale, Pierluigi, Oliver, Antonio, Pintado, Vicente, Gasch, Oriol, Martinez-Martinez, Luis, Pitout, Johann, Akova, Murat, Pena, Carmen, Molina Gil-Bermejo, Jose, Hernandez, Alicia, Venditti, Mario, Prim, Nuria, Bou, German, Tacconelli, Evelina, Tumbarello, Mario, Hamprecht, Axel, Giamarellou, Helen, Almela, Manel, Perez, Federico, Schwaber, Mitchell J., Bermejo, Joaquin, Lowman, Warren, Hsueh, Po-Ren, Ramon Pano-Pardo, Jose, Torre-Cisneros, Julian, Souli, Maria, Bonomo, Robert A., Carmeli, Yehuda, Paterson, David L., Pascual, Alvaro, and Rodriguez-Bano, Jesus
Abstract: Background. There is little information about the efficacy of active alternative drugs to carbapenems except beta-lactam/beta-lactamase inhibitors for the treatment of bloodstream infections (BSIs) due to extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E). The objective of this study was to assess the outcomes of patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OADs]) or carbapenems. Methods. A multinational retrospective cohort study of patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed. Cox regression including a propensity score for receiving OADs was performed to analyze 30-day all-cause mortality as main outcome. Clinical failure and length of stay were also analyzed. Results. Overall, 335 patients were included; 249 received empiric carbapenems and 86 OADs. The most frequent OADs were aminoglycosides (43 patients) and fluoroquinolones (20 patients). Empiric therapy with OADs was not associated with mortality (hazard ratio [HR], 0.75; 95% confidence interval [CI],.38-1.48) in the Cox regression analysis. Propensity score-matched pairs, subgroups, and sensitivity analyses did not show different trends; specifically, the adjusted HR for aminoglycosides was 1.05 (95% CI,.51-2.16). OADs were neither associated with 14-day clinical failure (adjusted odds ratio, 0.62; 95% CI,.29-1.36) nor length of hospital stay. Conclusions. We were unable to show that empiric treatment with OAD was associated with a worse outcome compared with carbapenems. This information allows more options to be considered for empiric therapy, at least for some patients, depending on local susceptibility patterns of ESBL-E.
Published: 2017

45. Antimicrobials : a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Author: Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppäniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio, Viale, Perluigi, II kirurgian klinikka, Department of Surgery, and Clinicum
Subjects: CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE, INTENSIVE-CARE-UNIT, SPECTRUM-BETA-LACTAMASE, VENTILATOR-ASSOCIATED PNEUMONIA, CLINICAL-PRACTICE GUIDELINES, GRAM-NEGATIVE BACTERIA, CLOSTRIDIUM-DIFFICILE INFECTION, BLOOD-STREAM INFECTIONS, 3126 Surgery, anesthesiology, intensive care, radiology, CRITICALLY-ILL PATIENTS, VANCOMYCIN-RESISTANT ENTEROCOCCI
Abstract: Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
Published: 2016

46. A Predictive Model of Mortality in Patients With Bloodstream Infections due to Carbapenemase-Producing Enterobacteriaceae

Author: Gutiérrez Gutiérrez, Belén, Salamanca, Elena, de Cueto, Marina, Pascual, Alvaro, Rodríguez Baño, Jesús, Hsueh, Po Ren, Viale, Pierluigi, Paño Pardo, José Ramón, Venditti, Mario, Tumbarello, Mario, Daikos, George, Pintado, Vicente, Doi, Yohei, Tuon, Felipe Francisco, Karaiskos, Ilias, Machuca, Isabel, Schwaber, Mitchell J., Azap, Özlem Kurt, Souli, Maria, Roilides, Emmanuel, Pournaras, Spyros, Akova, Murat, Pérez, Federico, Bonomo, Robert A., Bermejo, Joaquín, Oliver, Antonio, Almela, Manel, Lowman, Warren, Almirante, Benito, Carmeli, Yehuda, Paterson, David L., Falcone, M., Russo, A., Giamarellou, H., Trecarichi, Enrico Maria, Losito, Angela Raffaella, García Vázquez, E., Hernández, A., Gómez, J., Iosifidis, E., Prim, N., Navarro, F., Mirelis, B., Origüen, J., San Juan, R., Fernández Ruiz, M., Larrosa, N., Puig Asensio, M., Cisneros, J. M., Molina, J., González, V., Rucci, V., Ruiz de Gopegui, E., Marinescu, C. I., Martínez Martínez, L., Fariñas, M. C., Cano, M. E., Gozalo, M., Mora Rillo, M., Navarro San Francisco, C., Peña, C., Gómez Zorrilla, S., Tubau, F., Tsakris, A., Zarkotou, O., Azap, Ö. K., Pitout, J., Virmani, D., Torre Cisneros, J., Natera, C., Helvaci, Ö., Sahin, A. O., Cantón, R., Ruiz, P., Bartoletti, M., Giannella, M., Taconelli, E., Riemenschneider, F., Calbo, E., Badia, C., Xercavins, M., Gasch, E., Fontanals, D., and Jové, E.
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, carbapenems, klebsiella pneumoniae, pneumoniae carbapenemase, 030106 microbiology, Bacteremia, Comorbidity, Logistic regression, Settore MED/17 - MALATTIE INFETTIVE, Sensitivity and Specificity, beta-Lactamases, Decision Support Techniques, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, Enterobacteriaceae, Predictive Value of Tests, Internal medicine, medicine, Humans, In patient, 030212 general & internal medicine, Aged, Anti-Bacterial Agents, Enterobacteriaceae Infections, Female, Logistic Models, Middle Aged, Retrospective Studies, Receiver operating characteristic, business.industry, Medicine (all), Retrospective cohort study, General Medicine, medicine.disease, Surgery, Predictive value of tests, Observational study, business
Abstract: Objective To develop a score to predict mortality in patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE). Patients and Methods A multinational retrospective cohort study (INCREMENT project) was performed from January 1, 2004, through December 31, 2013. Patients with clinically relevant monomicrobial BSIs due to CPE were included and randomly assigned to either a derivation cohort (DC) or a validation cohort (VC). The variables were assessed on the day the susceptibility results were available, and the predictive score was developed using hierarchical logistic regression. The main outcome variable was 14-day all-cause mortality. The predictive ability of the model and scores were measured by calculating the area under the receiver operating characteristic curve. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for different cutoffs of the score. Results The DC and VC included 314 and 154 patients, respectively. The final logistic regression model of the DC included the following variables: severe sepsis or shock at presentation (5 points); Pitt score of 6 or more (4 points); Charlson comorbidity index of 2 or more (3 points); source of BSI other than urinary or biliary tract (3 points); inappropriate empirical therapy and inappropriate early targeted therapy (2 points). The score exhibited an area under the receiver operating characteristic curve of 0.80 (95% CI, 0.74-0.85) in the DC and 0.80 (95% CI, 0.73-0.88) in the VC. The results for 30-day all-cause mortality were similar. Conclusion A validated score predictive of early mortality in patients with BSIs due to CPE was developed. Trial Registration clinicaltrials.gov Identifier: NCT01 764490.
Published: 2016

47. Ertapenem for the treatment of bloodstream infections due to ESBL-producing Enterobacteriaceae: A multinational pre-registered cohort study

Author: Gutiérrez-Gutiérrez, Belén, Bonomo Robert, A., Carmeli, Yehuda, Paterson David, L., Almirante, Benito, Martínez-Martínez, Luis, Oliver, Antonio, Calbo, Esther, Peña, Carmen, Akova, Murat, Pitout, Johann, Origüen, Julia, Pintado, Vicente, García-Vázquez, Elisa, Gasch, Oriol, Hamprecht, Axel, Prim, Nuria, Tumbarello, Mario, Bou, German, Viale, Pierluigi, Tacconelli, Evelina, Almela, Manel, Pérez, Federico, Giamarellou, Helen, Cisneros José Miguel, Schwaber Mitchell, J., Venditti, Mario, Lowman, Warren, Bermejo, Joaquín, Hsueh, Po-Ren, Mora-Rillo, Marta, Gracia-Ahulfinger, Irene, Pascual, Alvaro, Rodríguez-Baño, Jesús, Karaiskos, I., Trecarichi, E. M., Losito, A. R., Hernández, A., Gómez, J., Navarro, F., Mirelis, B., Larrosa, N., Puig, M., Rucci, V., Bartoletti, M., Giannella, M., Riemenschneider, F., Badia, C., Xercavins, M., Gálvez, J., de Cueto, M., Salamanca, E., Falcone, M., Russo, A., Daikos, G., Paterson, D. L., Roilides, E., Iosifidis, E., Doi, Y., Tuon, F. F., San Juan, R., Fernández-Ruiz, M., Molina, J., González, V., Ruiz de Gopegui, E., Marinescu, C. I., Fariñas, M. C., Cano, M. E., Gozalo, M., Paño-Pardo, J. R., Navarro-San Francisco, C., Gómez-Zorrilla, S., Tubau, F., Pournaras, S., Tsakris, A., Zarkotou, O., Azap, Ö. K., Souli, M., Antoniadou, A., Poulakou, G., Virmani, D., Machuca, I., Pérez-Nadales, E., Torre-Cisneros, J., Helvaci, Ö., Sahin, A. O., Cantón, R., Ruiz, P., Fontanals, D., Jové, E., Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Red Española de Investigación en Patología Infecciosa, US Department of Veterans Affairs, Geriatric Research Education and Clinical Center (US), National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), and İç Hastalıkları
Subjects: 0301 basic medicine, Male, Carbapenem, Pediatrics, chemistry.chemical_compound, Septic shock, polycyclic compounds, Molecular targeted therapy, Pharmacology (medical), Pharmacology & Pharmacy, Original Research, Enterobacteriaceae Infections, Middle Aged, Anti-Bacterial Agents, Treatment Outcome, Infectious Diseases, Cohort, Female, Sensitivity analysis, Ertapenem, medicine.drug, Cohort study, Microbiology (medical), medicine.medical_specialty, Aged, Carbapenems, Enterobacteriaceae, Humans, Retrospective Studies, Sepsis, Survival Analysis, beta-Lactamases, beta-Lactams, 030106 microbiology, Settore MED/17 - MALATTIE INFETTIVE, Microbiology, 03 medical and health sciences, Severe extended-spectrum beta lactamases, Internal medicine, medicine, Mortality, Pharmacology, business.industry, Retrospective cohort study, biochemical phenomena, metabolism, and nutrition, medicine.disease, bacterial infections and mycoses, chemistry, Propensity score matching, bacteria, Bloodstream infections, business, human activities
Abstract: REIPI/ESGBIS/INCREMENT Group: J. Gálvez, M. de Cueto, E. Salamanca, M. Falcone, A. Russo, G. Daikos, I. Karaiskos, E. M. Trecarichi, A. R. Losito, D. L. Paterson, A. Hernández, J. Gómez, E. Roilides, E. Iosifidis, Y. Doi, F. F. Tuon, F. Navarro, B. Mirelis, R. San Juan, M. Fernández-Ruiz, N. Larrosa, M. Puig, J. Molina, V. González, V. Rucci, E. Ruiz de Gopegui, C. I. Marinescu, M. C. Fariñas, M. E. Cano, M. Gozalo, J. R. Paño-Pardo, C. Navarro-San Francisco, S. Gómez-Zorrilla, F. Tubau, S. Pournaras, A. Tsakris, O. Zarkotou, Ö. K. Azap, M. Souli, A. Antoniadou, G. Poulakou, D. Virmani, I. Machuca, E. Pérez-Nadales, J. Torre-Cisneros, Ö. Helvaci, A. O. Sahin, R. Cantón, P. Ruiz, M. Bartoletti, M. Giannella, F. Riemenschneider, C. Badia, M. Xercavins, D. Fontanals, E. Jové., [Objectives] Data about the efficacy of ertapenem for the treatment of bloodstream infections (BSI) due to ESBL-producing Enterobacteriaceae (ESBL-E) are limited. We compared the clinical efficacy of ertapenem and other carbapenems in monomicrobial BSI due to ESBL-E., [Methods] A multinational retrospective cohort study (INCREMENT project) was performed (ClinicalTrials.gov identifier: NCT01764490). Patients given monotherapy with ertapenem or other carbapenems were compared. Empirical and targeted therapies were analysed. Propensity scores were used to control for confounding; sensitivity analyses were performed in subgroups. The outcome variables were cure/improvement rate at day 14 and all-cause 30 day mortality., [Results] The empirical therapy cohort (ETC) and the targeted therapy cohort (TTC) included 195 and 509 patients, respectively. Cure/improvement rates were 90.6% with ertapenem and 75.5% with other carbapenems (P = 0.06) in the ETC and 89.8% and 82.6% (P = 0.02) in the TTC, respectively; 30 day mortality rates were 3.1% and 23.3% (P = 0.01) in the ETC and 9.3% and 17.1% (P = 0.01) in the TTC, respectively. Adjusted ORs (95% CI) for cure/improvement with empirical and targeted ertapenem were 1.87 (0.24–20.08; P = 0.58) and 1.04 (0.44–2.50; P = 0.92), respectively. For the propensity-matched cohorts it was 1.18 (0.43–3.29; P = 0.74). Regarding 30 day mortality, the adjusted HR (95% CI) for targeted ertapenem was 0.93 (0.43–2.03; P = 0.86) and for the propensity-matched cohorts it was 1.05 (0.46–2.44; P = 0.90). Sensitivity analyses were consistent except for patients with severe sepsis/septic shock, which showed a non-significant trend favouring other carbapenems., [Conclusions] Ertapenem appears as effective as other carbapenems for empirical and targeted therapy of BSI due to ESBL-E, but further studies are needed for patients with severe sepsis/septic shock., This study was funded by the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III - co-financed by European Development Regional Fund ‘A way to achieve Europe’ ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015) and FIS (PI10/02021). The study was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs, the Veterans Affairs Merit Review Program and the Geriatric Research Education and Clinical Center VISN 10 (VISN 10 GRECC) to R. A. B. The NIAID of the NIH under Award Numbers R01AI072219 and R01AI063517 also supported R. A. B.
Published: 2016

48. The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship—results from an international cross-sectional survey

Author: Sartelli, Massimo, primary, Labricciosa, Francesco M., additional, Barbadoro, Pamela, additional, Pagani, Leonardo, additional, Ansaloni, Luca, additional, Brink, Adrian J., additional, Carlet, Jean, additional, Khanna, Ashish, additional, Chichom-Mefire, Alain, additional, Coccolini, Federico, additional, Di Saverio, Salomone, additional, May, Addison K., additional, Viale, Pierluigi, additional, Watkins, Richard R., additional, Scudeller, Luigia, additional, Abbo, Lilian M., additional, Abu-Zidan, Fikri M., additional, Adesunkanmi, Abdulrashid K., additional, Al-Dahir, Sara, additional, Al-Hasan, Majdi N., additional, Alis, Halil, additional, Alves, Carlos, additional, Araujo da Silva, André R., additional, Augustin, Goran, additional, Bala, Miklosh, additional, Barie, Philip S., additional, Beltrán, Marcelo A., additional, Bhangu, Aneel, additional, Bouchra, Belefquih, additional, Brecher, Stephen M., additional, Caínzos, Miguel A., additional, Camacho-Ortiz, Adrian, additional, Catani, Marco, additional, Chandy, Sujith J., additional, Jusoh, Asri Che, additional, Cherry-Bukowiec, Jill R., additional, Chiara, Osvaldo, additional, Colak, Elif, additional, Cornely, Oliver A., additional, Cui, Yunfeng, additional, Demetrashvili, Zaza, additional, De Simone, Belinda, additional, De Waele, Jan J., additional, Dhingra, Sameer, additional, Di Marzo, Francesco, additional, Dogjani, Agron, additional, Dorj, Gereltuya, additional, Dortet, Laurent, additional, Duane, Therese M., additional, Elmangory, Mutasim M., additional, Enani, Mushira A., additional, Ferrada, Paula, additional, Esteban Foianini, J., additional, Gachabayov, Mahir, additional, Gandhi, Chinmay, additional, Ghnnam, Wagih Mommtaz, additional, Giamarellou, Helen, additional, Gkiokas, Georgios, additional, Gomi, Harumi, additional, Goranovic, Tatjana, additional, Griffiths, Ewen A., additional, Guerra Gronerth, Rosio I., additional, Haidamus Monteiro, Julio C., additional, Hardcastle, Timothy C., additional, Hecker, Andreas, additional, Hodonou, Adrien M., additional, Ioannidis, Orestis, additional, Isik, Arda, additional, Iskandar, Katia A., additional, Kafil, Hossein S., additional, Kanj, Souha S., additional, Kaplan, Lewis J., additional, Kapoor, Garima, additional, Karamarkovic, Aleksandar R., additional, Kenig, Jakub, additional, Kerschaever, Ivan, additional, Khamis, Faryal, additional, Khokha, Vladimir, additional, Kiguba, Ronald, additional, Kim, Hong B., additional, Ko, Wen-Chien, additional, Koike, Kaoru, additional, Kozlovska, Iryna, additional, Kumar, Anand, additional, Lagunes, Leonel, additional, Latifi, Rifat, additional, Lee, Jae G., additional, Lee, Young R., additional, Leppäniemi, Ari, additional, Li, Yousheng, additional, Liang, Stephen Y., additional, Lowman, Warren, additional, Machain, Gustavo M., additional, Maegele, Marc, additional, Major, Piotr, additional, Malama, Sydney, additional, Manzano-Nunez, Ramiro, additional, Marinis, Athanasios, additional, Martinez Casas, Isidro, additional, Marwah, Sanjay, additional, Maseda, Emilio, additional, McFarlane, Michael E., additional, Memish, Ziad, additional, Mertz, Dominik, additional, Mesina, Cristian, additional, Mishra, Shyam K., additional, Moore, Ernest E., additional, Munyika, Akutu, additional, Mylonakis, Eleftherios, additional, Napolitano, Lena, additional, Negoi, Ionut, additional, Nestorovic, Milica D., additional, Nicolau, David P., additional, Omari, Abdelkarim H., additional, Ordonez, Carlos A., additional, Paiva, José-Artur, additional, Pant, Narayan D., additional, Parreira, Jose G., additional, Pędziwiatr, Michal, additional, Pereira, Bruno M., additional, Ponce-de-Leon, Alfredo, additional, Poulakou, Garyphallia, additional, Preller, Jacobus, additional, Pulcini, Céline, additional, Pupelis, Guntars, additional, Quiodettis, Martha, additional, Rawson, Timothy M., additional, Reis, Tarcisio, additional, Rems, Miran, additional, Rizoli, Sandro, additional, Roberts, Jason, additional, Pereira, Nuno Rocha, additional, Rodríguez-Baño, Jesús, additional, Sakakushev, Boris, additional, Sanders, James, additional, Santos, Natalia, additional, Sato, Norio, additional, Sawyer, Robert G., additional, Scarpelini, Sandro, additional, Scoccia, Loredana, additional, Shafiq, Nusrat, additional, Shelat, Vishalkumar, additional, Sifri, Costi D., additional, Siribumrungwong, Boonying, additional, Søreide, Kjetil, additional, Soto, Rodolfo, additional, de Souza, Hamilton P., additional, Talving, Peep, additional, Trung, Ngo Tat, additional, Tessier, Jeffrey M., additional, Tumbarello, Mario, additional, Ulrych, Jan, additional, Uranues, Selman, additional, Van Goor, Harry, additional, Vereczkei, Andras, additional, Wagenlehner, Florian, additional, Xiao, Yonghong, additional, Yuan, Kuo-Ching, additional, Wechsler-Fördös, Agnes, additional, Zahar, Jean-Ralph, additional, Zakrison, Tanya L., additional, Zuckerbraun, Brian, additional, Zuidema, Wietse P., additional, and Catena, Fausto, additional
Published: 2017
Full Text: View/download PDF

49. SASCM guideline for daptomycin use in South Africa – 2017 update

Author: Lowman, Warren, primary, Coetzee, Jennifer, additional, and Perovic, Olga, additional
Published: 2017
Full Text: View/download PDF

50. Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study

Author: Gutiérrez-Gutiérrez, Belén, primary, Salamanca, Elena, additional, de Cueto, Marina, additional, Hsueh, Po-Ren, additional, Viale, Pierluigi, additional, Paño-Pardo, José Ramón, additional, Venditti, Mario, additional, Tumbarello, Mario, additional, Daikos, George, additional, Cantón, Rafael, additional, Doi, Yohei, additional, Tuon, Felipe Francisco, additional, Karaiskos, Ilias, additional, Pérez-Nadales, Elena, additional, Schwaber, Mitchell J, additional, Azap, Özlem Kurt, additional, Souli, Maria, additional, Roilides, Emmanuel, additional, Pournaras, Spyros, additional, Akova, Murat, additional, Pérez, Federico, additional, Bermejo, Joaquín, additional, Oliver, Antonio, additional, Almela, Manel, additional, Lowman, Warren, additional, Almirante, Benito, additional, Bonomo, Robert A, additional, Carmeli, Yehuda, additional, Paterson, David L, additional, Pascual, Alvaro, additional, Rodríguez-Baño, Jesús, additional, del Toro, M D, additional, Gálvez, J, additional, Falcone, M, additional, Russo, A, additional, Giamarellou, H, additional, Trecarichi, E M, additional, Losito, A R, additional, García-Vázquez, E, additional, Hernández, A, additional, Gómez, J, additional, Bou, G, additional, Iosifidis, E, additional, Prim, N, additional, Navarro, F, additional, Mirelis, B, additional, Skiada, A, additional, Origüen, J, additional, Juan, R San, additional, Fernández-Ruiz, M, additional, Larrosa, N, additional, Puig-Asensio, M, additional, Cisneros, J M, additional, Molina, J, additional, González, V, additional, Rucci, V, additional, de Gopegui, E Ruiz, additional, Marinescu, C I, additional, Martínez-Martínez, L, additional, Fariñas, M C, additional, Cano, M E, additional, Gozalo, M, additional, Mora-Rillo, M, additional, Francisco, C Navarro-San, additional, Peña, C, additional, Gómez-Zorrilla, S, additional, Tubau, F, additional, Tsakris, A, additional, Zarkotou, O, additional, Antoniadou, A, additional, Poulakou, G, additional, Pitout, J, additional, Virmani, D, additional, Torre-Cisneros, J, additional, Guzmán-Puche, J, additional, Helvaci, Ö, additional, Sahin, A O, additional, Pintado, V, additional, Ruiz, P, additional, Bartoletti, M, additional, Giannella, M, additional, Tacconelli, E, additional, Riemenschneider, F, additional, Calbo, E, additional, Badia, C, additional, Xercavins, M, additional, Gasch, O, additional, Fontanals, D, additional, and Jové, E, additional
Published: 2017
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

179 results on '"Lowman, Warren"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources