168 results on '"Lower extremity weakness"'
Search Results
2. Intradural lumbar disc herniation of L2–L3: A case report and literature review
- Author
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Xipeng Chen, Yuanpei Cheng, and Han Wu
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lumbar disc herniation ,intradural lumbar disc herniation ,lower back pain ,lower extremity weakness ,case report ,Surgery ,RD1-811 - Abstract
BackgroundIntradural lumbar disc herniation (ILDH), especially upper lumbar intradural disc herniation, is a rare type of lumbar disc herniation (LDH). However, it may have severe and complex symptoms, causing serious impact on the patients. Additionally, it is difficult to be diagnosed with limited experience. Few studies on L2–L3 ILDH have been reported in the literature. This study presents such a case and reviews the incidence, etiology, symptoms, diagnosis and treatment of this disease, so as to provide guidance and experience for clinicians.Case presentationA 27-year-old male patient had a one-month history of severe lower back pain and left lower extremity weakness after lumbar sprain. He could not walk due to progressive symptoms. Physical examination revealed that straight leg raising and femoral nerve stretch tests on the left side were positive. Magnetic resonance imaging of lumbar showed an intradural disc protruding into the ventral dural sac at the L2–L3 level. He was diagnosed ILDH of L2–L3, finally. An urgent operation was performed to remove the intradural disc fragment. The patient's symptoms improved significantly, postoperatively. After eight months of follow-up, he returned to normal life with only slight lower back pain.ConclusionsILDH at the L2–L3 level is an extremely rare type of LDH. Its diagnosis often requires a combination of symptom, physical examination, and imaging examination due to no typical symptoms or imaging features. A detailed preoperative plan including the definition of the position, calcification, migration, and adhesion of intradural intervertebral discs to decrease the risk of surgery, prevent the occurrence of complications, and promote postoperative prognosis of patients.
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- 2023
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3. Safety and efficacy of electrical stimulation for lower-extremity muscle weakness in intensive care unit 2019 Novel Coronavirus patients: A phase I double-blinded randomized controlled trial
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Alejandro Zulbaran-Rojas, Ramkinker Mishra, Naima Rodriguez, Rasha O. Bara, Myeounggon Lee, Amir Behzad Bagheri, James P. Herlihy, Muhammad Siddique, and Bijan Najafi
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COVID-19 ,critically ill patients ,lower extremity weakness ,electrical stimulation ,intensive care unit ,Medicine (General) ,R5-920 - Abstract
BackgroundIntensive care unit (ICU) prolonged immobilization may lead to lower-extremity muscle deconditioning among critically ill patients, particularly more accentuated in those with 2019 Novel Coronavirus (COVID-19) infection. Electrical stimulation (E-Stim) is known to improve musculoskeletal outcomes. This phase I double-blinded randomized controlled trial examined the safety and efficacy of lower-extremity E-Stim to prevent muscle deconditioning.MethodsCritically ill COVID-19 patients admitted to the ICU were randomly assigned to control (CG) or intervention (IG) groups. Both groups received daily E-Stim (1 h) for up to 14 days on both gastrocnemius muscles (GNMs). The device was functional in the IG and non-functional in the CG. Primary outcomes included ankle strength (Ankles) measured by an ankle-dynamometer, and GNM endurance (GNMe) in response to E-Stim assessed with surface electromyography (sEMG). Outcomes were measured at baseline, 3 and 9 days.ResultsThirty-two (IG = 16, CG = 16) lower extremities in 16 patients were independently assessed. The mean time between ICU admission and E-Stim therapy delivery was 1.8 ± 1.9 days (p = 0.29). At 3 days, the IG showed an improvement compared to the CG with medium effect sizes for Ankles (p = 0.06, Cohen’s d = 0.77) and GNMe (p = 0.06, d = 0.69). At 9 days, the IG GNMe was significantly higher than the CG (p = 0.04, d = 0.97) with a 6.3% improvement from baseline (p = 0.029). E-Stim did not alter vital signs (i.e., heart/respiratory rate, blood saturation of oxygen), showed no adverse events (i.e., pain, skin damage, discomfort), nor interfere with ICU standard of care procedures (i.e., mechanical ventilation, prone rotation).ConclusionThis study supports the safety and efficacy of early E-Stim therapy to potentially prevent deterioration of lower-extremity muscle conditions in critically ill COVID-19 patients recently admitted to the ICU. If confirmed in a larger sample, E-Stim may be used as a practical adjunctive therapy.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT04685213].
- Published
- 2022
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4. Causes of lower extremity weaknesses after posterior lumbar spine fusion surgery and therapeutic effects of active surgical exploration
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Rui Wang, Chunde Li, Xiaodong Yi, Hailin Lu, Yu Wang, and Hong Li
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Posterior lumbar spine fusion surgery ,Neurological complications ,Lower extremity weakness ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background This study was aimed at investigating the causes of lower extremity weaknesses after posterior lumbar spine fusion surgery and looking at subsequent treatment strategies. Methods Patients who underwent posterior lumbar spine fusion surgery in the Peking University First Hospital between January 2009 and December 2018 were counted. Those who needed secondary surgery because of subsequent lower extremity weaknesses were selected. CT scans and MRIs were used to evaluate the reasons for weaknesses before secondary surgery. Muscle strength was evaluated after surgery. Results Thirty patients (30/4078, 0.74%) required a secondary surgery because of lower extremity weaknesses after posterior lumbar spine fusion surgery. The main causes of weakness were (1) internal fixation malposition and loosening (11 patients, 36%), (2) epidural hematomas (9 patients, 30%), (3) insufficient decompression (5 patients, 17%), and (4) nerve root edemas (5 patients, 17%). Weakness occurred on average 2.9 days after surgery (1–9 days). Twenty-seven patients (90%) got improved muscle strength after their secondary surgery. Conclusions Iatrogenic neurologic deficits and lower extremity weaknesses were rare complications after posterior lumbar spine fusion surgeries, but important to recognize and manage. The main causes of weakness were internal fixation malposition and loosening, epidural hematomas, insufficient decompression, or root edemas. There may be positive, therapeutic effects to subsequent, active surgical exploration.
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- 2020
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5. Hypogastric Artery Stenting for Chronic Intermittent Spinal Cord Ischemia After Thoracic Endovascular Aortic Repair.
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Gronert, Catharina, Tsilimparis, Nikolaos, Panuccio, Giuseppe, Eleshra, Ahmed, Rohlffs, Fiona, and Kölbel, Tilo
- Abstract
Purpose: To report a case of chronic intermittent spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) and its successful treatment using hypogastric artery stenting.Case Report: A 79-year-old patient presented in May 2013 with a thoracic aortic aneurysm (TAA) and a contained rupture. He urgently underwent TEVAR that covered 274 mm of descending thoracic aorta without immediate postoperative signs of acute SCI. At 3-month follow-up, he reported repeating incidents of sudden lower extremity weakness leading to a fall with a humerus fracture. A neurological consultation revealed the tentative diagnosis of intermittent SCI caused by TEVAR and initially recommended a conservative approach. During the following year there was no clinical improvement of the symptoms. Computed tomography angiography showed a high-grade stenosis of the right hypogastric artery, which was stented in November 2014 to improve the collateral network of spinal cord perfusion. Following treatment, the patient had no further neurological symptoms; at 32 months after the reintervention, the imaging follow-up documented a patent stent and continued exclusion of the TAA.Conclusion: Intermittent neurological symptoms after TEVAR should be suspected as chronic intermittent SCI. The improvement of collateral networks of the spinal cord by revascularization of the hypogastric artery is a viable treatment option. [ABSTRACT FROM AUTHOR]- Published
- 2020
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6. A hemodialysis patient with difficulty ambulating: Answers.
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Mann, Nina, Fayemi, Annemarie, Myles, Melissa, Kelley, Nicole, Carmine, Brian, Richmond, Camilla, and Traum, Avram Z.
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DIFFERENTIAL diagnosis , *LEG , *MUSCLE weakness , *DIETARY supplements , *POLYNEUROPATHIES , *WALKING , *GUILLAIN-Barre syndrome , *HEMODIALYSIS , *MICRONUTRIENTS - Abstract
The article presents answers to a clinical quiz about a hemodialysis patient with difficulty ambulating.
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- 2021
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7. Transverse Myelitis in Acute Hepatitis A Infection: The Rare Co-Occurrence of Hepatology and Neurology
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Piyanant Chonmaitree and Kulthida Methawasin
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Transverse myelitis ,Acute hepatitis A ,Lower extremity weakness ,Jaundice ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Transverse myelitis refers to the inflammatory process involving the spinal cord. Clinical features can be either acute or subacute onset that results in neurological deficits such as weakness and/or numbness of extremities as well as autonomic dysfunctions. While there are some etiologies related, a viral infection is common. However, the hepatitis A virus rarely causes myelitis. This report provides details of a hepatitis A infectious patient who developed myelitis as comorbidity. Although, the disability was initially severe, the patient successfully recovered with corticosteroid treatment.
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- 2016
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8. Spinal Cord Protection Strategies
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Augoustides, John G. T., Subramaniam, Kathirvel, editor, Park, Kyung W., editor, and Subramaniam, Balachundhar, editor
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- 2011
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9. Impact of an ankle foot orthosis on reactive stepping in young adults
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Kurt Jackson, Kimberly Edginton Bigelow, Kyra E. Twohy, and Allison Kinney
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Male ,medicine.medical_specialty ,Biophysics ,Foot Orthoses ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Ankle/foot orthosis ,medicine ,Humans ,Lower extremity weakness ,Orthopedics and Sports Medicine ,Force platform ,Young adult ,Dynamic balance ,Gait ,Balance (ability) ,business.industry ,Rehabilitation ,030229 sport sciences ,Biomechanical Phenomena ,medicine.anatomical_structure ,Female ,Ankle ,business ,Ankle Joint ,030217 neurology & neurosurgery - Abstract
Background Ankle-foot orthoses (AFOs) have been shown to improve gait and static balance in individuals with lower extremity weakness and instability. However, the effects of AFOs on dynamic balance reactions including reactive stepping responses are not well known. Therefore, the purpose of this study was to determine the effects of an AFO on reactive stepping responses in healthy young adults. Research question Does an AFO alter reactive stepping responses in healthy young adults? Methods Twenty healthy young adults completed 10 reactive stepping trials using a lean-and-release system for each of three AFO conditions: 1) no AFO, 2) AFO on left leg and 3) AFO on right leg. Trials were recorded using 3D motion capture and force plates. Stepping limb preference and temporal, spatial, and kinematic variables were measured. Differences between conditions were determined by a one-way ANOVA with a Tukey post-hoc. Results With no AFO, participants demonstrated a preference for stepping with the right leg, 7.0 ± 3.9 of 10 trials. With an AFO on the right leg, this preference decreased to 5.7 ± 4.4 (p = 0.03). With an AFO on the left leg, this preference increased to 8.1 ± 3.3 (p = 0.03). Reaction times were not significantly different between conditions, but participants took a significantly shorter reactive step with the leg wearing the AFO. Peak ankle, knee, and hip joint angles were significantly less with the AFO on the stepping limb compared to the stance limb. Significance This study shows that AFO use can influence reactive stepping limb preference and stepping limb kinematics in healthy young adults. These results can inform future research on AFO users with gait impairments. These finding may also be helpful in developing interventions to address the specific effects of an AFO on reactive stepping responses.
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- 2021
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10. A Case of Korean Medicine Treatments Including Chuna Therapy in Lower Extremity Weakness and Gait Disturbance Due to Lumbar Disk Herniation and Spinal Stenosis
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Song-Mi Park, Su-Eun Jung, and Sung-Woo Cho
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medicine.medical_specialty ,Physical medicine and rehabilitation ,Lumbar ,Gait Disturbance ,Spinal stenosis ,business.industry ,medicine ,Lower extremity weakness ,medicine.disease ,business - Published
- 2021
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11. Myositis and myopathy of sarcoidosis: A case report
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Tucker v R. Burr and Joao Kazan-Tannus
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lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,Sarcoidosis ,lcsh:R895-920 ,Myopathy ,Case Report ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Rare case ,Biopsy ,Medicine ,Lower extremity weakness ,Radiology, Nuclear Medicine and imaging ,Myositis ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Pelvic girdle musculature ,Radiology ,medicine.symptom ,Differential diagnosis ,business ,030217 neurology & neurosurgery - Abstract
Muscular manifestations of sarcoidosis are commonly found on biopsy but rare on correlated imaging. We present a rare case of a 36-year-old male patient with sarcoid myositis and image findings of active myositis in the lower back and pelvic girdle musculature. This case suggests considering sarcoidosis as a differential diagnosis in the setting of chest findings and new lower back and lower extremity weakness.
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- 2021
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12. Neuropatía periférica en tres miembros de una familia tras intoxicación aguda con monóxido de carbono: reporte de caso
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Juan Fernando Escobar, Daniel F. Gallego, and María Eugenia Zuluaga
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0301 basic medicine ,Carbon monoxide poisoning ,business.industry ,Signs and symptoms ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Peripheral neuropathy ,Anesthesia ,medicine ,Lower extremity weakness ,Presentation (obstetrics) ,Complication ,business ,030217 neurology & neurosurgery ,Peripheral nerve lesion ,Burning Pain - Abstract
La neuropatía periférica es una complicación presente en menos del 5 % de los casos de intoxicación por monóxido de carbono. El presente artículo describe las características clíni- cas de tres pacientes que acudieron con síntomas de lesión de nervio periférico tras estar expuestos a un incendio. Las variaciones clínicas incluyeron debilidad de miembros inferiores, parestesias y dolor tipo ardor. Se usaron estudios de electrodiagnóstico a los 14 días del evento, los cuales mostraron cambios no específicos. Al año del evento, uno de los pacientes confirmó lesión desmielinizante y axonal de nervio periférico. La presencia de signos y síntomas en conjunto con el antecedente de inhalación de humo, establecen el nexo etiológico con la intoxicación por monóxido de carbono. Este caso demuestra la importancia de considerar la intoxicación por monóxido de carbono como causa de neuropatía periférica. El diagnóstico debe fundamentarse en una historia clínica completa y puede apoyarse de electrodiagnóstico.
- Published
- 2020
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13. MANAGEMENT OF GRIDHRASI W.S.R TO SCIATICA THROUGH PANCHAKARMA: A CASE REPORT
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Kavita, Santosh Kumar Bhatted, and Alok Kumar Meher
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Sciatica ,medicine.medical_specialty ,Lumbar radiculopathy ,business.industry ,General Engineering ,Musculoskeletal disease ,Acute stage ,medicine ,Physical therapy ,General Earth and Planetary Sciences ,Lower extremity weakness ,Back pain radiating ,medicine.symptom ,business ,General Environmental Science - Abstract
Sciatica is a musculoskeletal disease with more than 10 million cases per year in India. It is a lumbar radiculopathy with mild, moderate or intense pain that radiates from lower back into right, left or both the legs. This article is a case report of a patient presenting with lower extremity weakness, lower back pain radiating towards both the legs and cramps in lower extremity. She was diagnosed for Gridhrasi and was admitted in IPD of All India Institute of Ayurveda. She was given Panchakarma treatment like Abhyanga, Rooksha Churna Pinda Swedana, Patra Pinda Swedana and Abhyantara Basti for a period of 18 days. There was 56.5% relief in her symptoms according to Rolland and Morris scale and on an average percentage according to subjective symptoms assessment criteria calculating relief in symptoms. On the basis of result it was observed that Panchakarma with proper Pathya Apathya can give satisfactory results in addition to it, if this intervention is given in acute stage then it may enhance the results.
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- 2020
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14. Risk Factors for Disability After Emergency Department Discharge in Older Adults
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Linda Leo-Summers, Thomas M. Gill, Justine M. Nagurney, Heather G. Allore, and Ling Han
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Male ,Pediatrics ,medicine.medical_specialty ,Longitudinal study ,Psychological intervention ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Odds Ratio ,medicine ,Humans ,Lower extremity weakness ,Disabled Persons ,Longitudinal Studies ,Multivariable model ,Aged ,Aged, 80 and over ,business.industry ,030208 emergency & critical care medicine ,General Medicine ,Emergency department ,Patient Discharge ,Confidence interval ,Relative risk ,Risk stratification ,Emergency Medicine ,Female ,Emergency Service, Hospital ,business - Abstract
Background We have previously shown that older adults discharged from the emergency department (ED) experience an increased disability burden within a 6-month time period after ED discharge. The objective of this study was to identify risk factors associated with increased disability burden among older adults discharged from the ED. Methods This study is part of an ongoing longitudinal study of 754 community-living persons aged ≥70 years. The analytic sample included 813 ED visits without hospitalization from 430 participants who had ≥1 visit to an ED during a 14-year follow-up period (1998-2012). Information on ED visits and disability burden in 13 functional activities was collected during monthly interviews. Twenty-nine candidate risk factors were evaluated for their independent associations with increased disability burden using a longitudinal multivariable model. Results In the multivariable analyses, age ≥ 85 (adjusted risk ratio [aRR] 1.14, 95% confidence interval [CI] 1.05 - 1.24), being unmarried (aRR 1.15, 95% CI 1.05 - 1.27), lower extremity weakness (aRR 1.20, 95% CI 1.07 - 1.34), and physical frailty (aRR 1.25, 95% CI 1.13 - 1.37) were associated with increased disability burden. As the number of risk factors increased, the predicted mean disability burden (on a scale 0-13) also increased, ranging from a value of 1.80 (95% CI 1.43 - 2.27) for 0 risk factors to a value of 8.59 (95% CI 7.93 - 9.29) for 4 risk factors. Conclusion Among older adults discharged from the ED, several risk factors were associated with increased disability burden over the following 6 months, including age ≥ 85, being unmarried, lower extremity weakness, and physical frailty. Further research is needed to evaluate whether risk stratification based on non-modifiable factors or interventions targeting modifiable risk factors improve functional outcomes for older adults discharged from the ED.
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- 2020
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15. Hypogastric Artery Stenting for Chronic Intermittent Spinal Cord Ischemia After Thoracic Endovascular Aortic Repair
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Nikolaos Tsilimparis, Tilo Kölbel, Ahmed Eleshra, Catharina Gronert, Fiona Rohlffs, and Giuseppe Panuccio
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medicine.medical_specialty ,business.industry ,Spinal cord ischemia ,Aortic repair ,medicine.disease ,Internal iliac artery ,Thoracic aortic aneurysm ,Surgery ,medicine.anatomical_structure ,medicine.artery ,medicine ,Lower extremity weakness ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
Purpose: To report a case of chronic intermittent spinal cord ischemia (SCI) after thoracic endovascular aortic repair (TEVAR) and its successful treatment using hypogastric artery stenting. Case Report: A 79-year-old patient presented in May 2013 with a thoracic aortic aneurysm (TAA) and a contained rupture. He urgently underwent TEVAR that covered 274 mm of descending thoracic aorta without immediate postoperative signs of acute SCI. At 3-month follow-up, he reported repeating incidents of sudden lower extremity weakness leading to a fall with a humerus fracture. A neurological consultation revealed the tentative diagnosis of intermittent SCI caused by TEVAR and initially recommended a conservative approach. During the following year there was no clinical improvement of the symptoms. Computed tomography angiography showed a high-grade stenosis of the right hypogastric artery, which was stented in November 2014 to improve the collateral network of spinal cord perfusion. Following treatment, the patient had no further neurological symptoms; at 32 months after the reintervention, the imaging follow-up documented a patent stent and continued exclusion of the TAA. Conclusion: Intermittent neurological symptoms after TEVAR should be suspected as chronic intermittent SCI. The improvement of collateral networks of the spinal cord by revascularization of the hypogastric artery is a viable treatment option.
- Published
- 2020
- Full Text
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16. A Rare Case of Primary Malignant Melanoma Presenting with Lower Extremity Weakness
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Ehsan Alimohammadi and Guive Sharifi
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medicine.medical_specialty ,business.industry ,Melanoma ,lcsh:Surgery ,retroperitoneum ,lcsh:RD1-811 ,intramedullary tumor ,medicine.disease ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Rare case ,melanoma ,medicine ,Lower extremity weakness ,Radiology ,business ,lcsh:Neurology. Diseases of the nervous system ,030217 neurology & neurosurgery ,Lumbosacral joint ,Neurological deficit - Abstract
The authors report a pathologically confirmed case of primary malignant melanoma located in the intradural lumbosacral area, which is extremely rare due to its atypical location and manifestation. However rare, primary malignant melanoma could present as an intradural tumor and cause neurological deficit.
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- 2020
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17. Cervical, intradural extramedullary solitary fibrous tumor of the spinal cord: A case report and review of the literature
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Neil R. Malhotra, Omar Choudhri, Michael E. Kritikos, Nikhil Sharma, and Gregory Glauser
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tumor ,medicine.medical_specialty ,Solitary fibrous tumor ,business.industry ,Case Report ,General Medicine ,medicine.disease ,Spinal cord ,spine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,medicine ,Lower extremity weakness ,Radiology ,business ,Intradural extramedullary ,030217 neurology & neurosurgery - Abstract
Solitary fibrous tumors (SFTs) are rare, spindle cell neoplasms of the mesenchymal origin. Lesions localized to the spine are exceptionally uncommon, only described in the literature in case reports and small case series. While these lesions are typically benign, there are a few reports in which they recur or present as malignancies. The patient presented in the case herein was a 72-year-old male, who presented with a 1-year history of lower extremity weakness, pain, and numbness and was found to have a cervical, intradural extramedullary tumor. In addition to the case report, the authors perform a thorough review of all previously published cases of spinal SFT.
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- 2020
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18. Patient reported quality of life in limb girdle muscular dystrophy
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Laurel Kovalchick, Matthew Wicklund, Peter B. Kang, Nicholas E. Johnson, Kameron Bates, Linda Lowes, Jeffrey Statland, Chad Heatwole, Volker Straub, Tahseen Mozaffar, and C. Weihl
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Male ,Population impact ,Medical Physiology ,Muscular Dystrophies ,Limb-Girdle ,Quality of life ,7.1 Individual care needs ,Surveys and Questionnaires ,Symptom duration ,80 and over ,Registries ,Muscular Dystrophy ,Dysferlin ,Genetics (clinical) ,Aged, 80 and over ,education.field_of_study ,Muscle Weakness ,Middle Aged ,Phenotype ,Neurology ,Calpain-3 ,Female ,medicine.symptom ,FKRP ,Adult ,medicine.medical_specialty ,Weakness ,Adolescent ,Intellectual and Developmental Disabilities (IDD) ,Population ,Clinical Sciences ,Patient report ,Article ,Young Adult ,Limb girdle muscular dystrophy ,Rare Diseases ,Clinical Research ,medicine ,Lower extremity weakness ,Humans ,In patient ,Patient Reported Outcome Measures ,education ,Aged ,Neurology & Neurosurgery ,business.industry ,Neurosciences ,medicine.disease ,Brain Disorders ,Muscular Dystrophies, Limb-Girdle ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Quality of Life ,Neurology (clinical) ,Management of diseases and conditions ,business ,Limb-girdle muscular dystrophy - Abstract
This study determined the frequency and impact of symptoms on quality of life (QoL) in patients diagnosed with limb girdle muscular dystrophy (LGMD). Participants with a diagnosis of LGMD in registries based at the Coalition to Cure Calpain-3, the Jain foundation, and the Global FKRP Registry competed a survey to report the frequency and relative impact of themes and symptoms of LGMD. Frequency, mean impact, and population impact scores were calculated, and responses were categorized by age, symptom duration, gender, employment status, use of assistive devices, and LGMD subtypes. 134 participants completed the survey. The most prevalent themes included an inability to do activities (100%), limitation with mobility (99.3%), and lower extremity weakness (97.0%). Themes with the greatest impact were: limitations with mobility, lower extremity weakness, and an inability to do activities. Symptom duration and the use of assistive devices were associated with the presence of multiple themes. Employment was associated with the impact of several themes with no differences in frequency. The prevalence and impact of these themes vary in the LMGD population. The most prevalent and impactful themes were related to weakness, but additional concerns related to emotional challenges should also be considered in clinical and research settings.
- Published
- 2022
19. Clinical Problem-Solving: Lower Extremity WeaknessParesthesia in an Immunocompromised Patient With a Complex Cancer History
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Shubadra Priyadarshini, Jennifer Adrissi, Nicholas E.F. Hac, Margaret Yu, Sarah M. Brooker, Karan Dixit, and Brian Stamm
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medicine.medical_specialty ,Urinary retention ,business.industry ,Cancer ,Immunocompromised patient ,Bowel incontinence ,medicine.disease ,Transverse myelitis ,Clinical Problem Solving ,Surgery ,03 medical and health sciences ,Myelopathy ,Myelogenous ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Lower extremity weakness ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
We present a case of new onset bilateral lower extremity weakness, paresthesia, urinary retention and bowel incontinence in a 51-year-old man. He had a complicated history of acute myelogenous leukemia with known central nervous system (CNS) and leptomeningeal involvement status post allogenic stem cell transplant complicated by chronic graft versus host disease (GVHD). We review the differential diagnosis as the physical exam and diagnostic results evolved. We also provide a review of the relevant literature supporting our favored diagnosis, as well as other competing diagnoses in this complicated case. The ultimate differential diagnosis included viral myelitis, treatment-related myelopathies, and CNS GVHD. The case provides a sobering reminder that even with an appropriate diagnostic workup, some cases remain refractory to therapeutic efforts. It also underscores the importance of a sensitive neurologic exam, given the significant clinico-radiological delay, and reviews the complex differential diagnosis for myelopathy.
- Published
- 2021
20. Massive Lumbar Disc Herniation Causing Cauda Equina Syndrome That Presents As Bladder and Bowel Dysfunction in the Absence of Lower Extremity Weakness
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Akihiko Inokuchi, Kimitaka Nakamura, Takahiro Hamada, Ryuta Imamura, and Takeshi Arizono
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medicine.medical_specialty ,Disc herniation ,clinical features ,postoperative outcomes ,business.industry ,General Engineering ,bladder and bowel dysfunction ,Cauda equina syndrome ,medicine.disease ,Surgery ,Lesion ,Bowel dysfunction ,medicine.anatomical_structure ,Orthopedics ,disc hernia ,medicine ,lower extremity weakness ,Sphincter ,Lower extremity weakness ,Lumbar disc herniation ,medicine.symptom ,Stage (cooking) ,business ,cauda equine syndrome - Abstract
The purpose of this report is to examine the features of cauda equina syndrome (CES) presenting as bladder and bowel dysfunction in the absence of lower extremity weakness. Between July 2015 and July 2016, we experienced four cases of massive LDH causing CES that presented as bladder and bowel dysfunction in the absence of lower extremity weakness. Herein, we describe the clinical features of these four patients (two males and two females) who were followed for a minimum of two years postoperatively. The mean age at the time of surgery was 46.8 years (range, 37-71 years). The disc herniation lesion was at the L4/5 level in one patient, and the L5/S1 level in three. The mean interval between the onset of CES and complete surgical decompression was 10.5 days (range, 1-18 days). Postoperative outcomes were better than poor in three of four cases, while one case had residual sphincter dysfunction. LDH causing CES is considered an indication for immediate surgical decompression; however, diagnosis of CES is likely to be delayed in atypical cases of CES that present as bladder and bowel dysfunction in the absence of lower extremity weakness. Diagnosis of CES tended to be delayed in cases without lower extremity weakness. Clinicians should recognize even sensory impairment alone of the dominant area supplied by S2-4 is an important diagnostic sign of CES in the early stage.
- Published
- 2021
21. Lower extremity weakness as the first sign of an abdominal aortic aneurysm
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Raúl Portas Gómez, Jose Antonio Pérez Gómez, Alejandro Delgado Molinos, Francisco José Farrais Expósito, Octavio de la Torre Scherak, Jose Carlos Cruz Arteaga, Angel López Castillo, Caleb Baz Figueroa, and Juan Carlos Moy Petersen
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Infrarenal abdominal aorta ,lcsh:Surgery ,030204 cardiovascular system & hematology ,Lower limb weakness ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Aortic aneurysm ,0302 clinical medicine ,Aneurysm ,Case report ,Medicine ,Lower extremity weakness ,cardiovascular diseases ,Lower extremity ,business.industry ,Spinal cord ischemia ,lcsh:RD1-811 ,medicine.disease ,Abdominal aortic aneurysm ,Surgery ,lcsh:RC666-701 ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business ,Abdominal aortic - Abstract
Giant aortic aneurysms are rare entities with a high mortality, and only a few cases have been described. Spinal cord ischemia secondary to an aortic aneurysm occurs even more rarely. We present the case of a giant aneurysm of the infrarenal abdominal aorta that was initially manifested through bilateral lower limb weakness.
- Published
- 2020
22. Strict Control of Blood Glucose With an Intravenous Insulin Infusion Decreases the Risk of Post-operative Lower Extremity Weakness After Complex Endovascular Aortic Aneurysm Repair
- Author
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Warren J. Gasper, Megan Hoffman, Jade S. Hiramoto, Timothy A.M. Chuter, and Linda M. Reilly
- Subjects
Aortic aneurysm repair ,Glucose control ,business.industry ,030204 cardiovascular system & hematology ,030230 surgery ,medicine.disease ,Asymptomatic ,Group B ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,Anesthesia ,medicine ,Lower extremity weakness ,Surgery ,medicine.symptom ,Post operative ,Cardiology and Cardiovascular Medicine ,business ,Paraplegia - Abstract
Objective/background It has previously been shown that post-operative lower extremity weakness (LEW) is associated with elevated blood and cerebrospinal fluid (CSF) glucose levels after branched endovascular aneurysms repair (BEVAR) of extensive aortic aneurysms. The purpose of this study was to determine whether a post-operative insulin infusion protocol (IIP) to achieve tight blood glucose control decreases the rate of LEW. Methods From October 2013, blood and CSF samples were collected pre-operatively, immediately post-operatively, and on post-operative day one in asymptomatic patients undergoing BEVAR. In July 2016, an IIP was initiated to maintain post-operative blood glucose levels Results Between October 2013 and April 2018, 43 patients underwent BEVAR. Twenty-two (group A) underwent BEVAR before initiation of the IIP. Of these, seven (32%) developed LEW within 48 h of repair. This was temporary in five (23%) and permanent in two (9%) patients. Post-operative blood glucose levels were significantly higher in patients with LEW compared with those without LEW (140 ± 27 mg/dL vs. 117 ± 16 mg/dL; p = .02). Post-operative CSF glucose levels were significantly higher in patients with LEW compared with those without LEW (102 ± 15 mg/dL vs. 77 ± 15 mg/dL; p = .001). The subsequent 21 patients (group B) underwent BEVAR after initiation of the IIP. No patient in group B developed LEW while on the IIP, but one (5%) developed paraplegia on post-operative day four. The rate of early LEW ( Conclusion An IIP to control blood glucose after BEVAR is associated with a decreased rate of post-operative LEW. Tight control of blood glucose should be considered after any extensive aortic reconstruction to minimise the risk of post-operative LEW.
- Published
- 2019
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23. A Case of Combination of Korean Medicine Treatments in Neurogenic Claudication and Lower Extremity Weakness due to Spinal Stenosis
- Subjects
medicine.medical_specialty ,business.industry ,Spinal stenosis ,Intervertebral Disc Displacement ,Medicine ,Lower extremity weakness ,Muscle weakness ,Neurogenic claudication ,medicine.symptom ,business ,medicine.disease ,Surgery - Published
- 2019
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24. Transverse Myelitis in Acute Hepatitis A Infection: The Rare Co-Occurrence of Hepatology and Neurology.
- Author
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Chonmaitree, Piyanant and Methawasin, fernando
- Subjects
TRANSVERSE myelitis ,HEPATITIS A ,HEPATOLOGY ,DIAGNOSIS - Abstract
Transverse myelitis refers to the inflammatory process involving the spinal cord. Clinical features can be either acute or subacute onset that results in neurological deficits such as weakness and/or numbness of extremities as well as autonomic dysfunctions. While there are some etiologies related, a viral infection is common. However, the hepatitis A virus rarely causes myelitis. This report provides details of a hepatitis A infectious patient who developed myelitis as comorbidity. Although, the disability was initially severe, the patient successfully recovered with corticosteroid treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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25. A hemodialysis patient with difficulty ambulating: Questions
- Author
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Mann, Nina, Fayemi, Annemarie, Myles, Melissa, Kelley, Nicole, Carmine, Brian, Richmond, Camilla, and Traum, Avram Z.
- Published
- 2021
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26. Diagnosis of Guillain-Barré Syndrome After Total Hip Arthroplasty: A Case Report
- Author
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James E. Feng, Daniel H. Wiznia, Afshin A. Anoushiravani, Paul J. Tesoriero, Scott Marwin, and Kiril Kiprovski
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Arthroplasty, Replacement, Hip ,Periprosthetic ,Guillain-Barre Syndrome ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Back pain ,Lower extremity weakness ,Humans ,Orthopedics and Sports Medicine ,Aged ,Muscle Weakness ,Guillain-Barre syndrome ,business.industry ,Disease progression ,Surgical debridement ,Immunoglobulins, Intravenous ,medicine.disease ,Surgery ,030104 developmental biology ,Disease Progression ,medicine.symptom ,Complication ,business ,030217 neurology & neurosurgery ,Total hip arthroplasty - Abstract
CASE REPORT A 67-year-old man presented with signs of acute periprosthetic infection after total hip arthroplasty (THA). Surgical debridement, antibiotics, and a head and liner exchange were performed. After showing no improvement, a single-stage revision was conducted. Postoperatively, he developed back pain and lower extremity weakness. Electrodiagnostic studies showed a Guillain-Barre syndrome (GBS) variant. Intravenous immunoglobulin was administered to halt disease progression. After 1 year, he still demonstrated neuromuscular deficits and required a cane for ambulation. CONCLUSION This case highlights GBS after THA. A high degree of clinical suspicion is essential to prevent misinterpretation as a postsurgical complication. LEVEL OF EVIDENCE V, case report.
- Published
- 2021
27. Lower Limb Orthoses
- Author
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Joseph B. Webster, William Lovegreen, Douglas P. Murphy, and Andrew Simoncini
- Subjects
medicine.medical_specialty ,Broad spectrum ,Physical medicine and rehabilitation ,business.industry ,Deformity ,Pain relief ,Lower extremity weakness ,Medicine ,medicine.symptom ,business ,Lower limb - Abstract
Lower limb orthoses are used in individuals with a wide range of conditions resulting in impaired functional mobility and loss of independence. These devices are most commonly utilized to enhance stability in both standing and walking when lower extremity weakness is present, but may also be indicated when correction of a lower limb deformity is the desired outcome. Lower limb orthoses can also be used in order to stabilize a joint in the setting of ligamentous deficiency as well as provide pain relief in the setting of joint deterioration. Lower limb orthoses encompass a broad spectrum of devices ranging from simple and inexpensive devices such as a knee sleeve or accommodative foot orthotic to sophisticated and expensive devices such as a computerized knee-ankle-foot orthosis. Significant advances have occurred in the materials and fabrication techniques used for lower limb orthoses allowing braces to be both more lightweight and durable. Orthoses incorporating microprocessor joint control are available, and it is anticipated that further advances will continue in the future. Despite these technology advances and the wide variety of available lower limb orthoses, clinical decision-making remains challenging because of the lack of comparative effectiveness research to guide orthosis selection. .
- Published
- 2021
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28. Delayed Spinal Cord Injury From Electrical Burns: Two Cases
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Lucy Wibbenmeyer, Colette Galet, and Tareq AlQasas
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Male ,Weakness ,Rehabilitation ,Flaccid paralysis ,business.industry ,medicine.medical_treatment ,Burns, Electric ,Recovery of Function ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Electrical Injuries ,Anesthesia ,Emergency Medicine ,medicine ,Lower extremity weakness ,Lower Extremity Paresis ,Humans ,Surgery ,medicine.symptom ,Presentation (obstetrics) ,business ,Spinal cord injury ,Spinal Cord Injuries - Abstract
Spinal cord injury has been described in only 2% to 5% of electrical injuries. When its presentation is delayed for several days to weeks after the initial injury, recovery is not the rule. Herein, we describe two patients who developed spinal cord injury from electrical burns. Case 1: A 60-year-old male presented with a 40% TBSA after contacting a power line. On hospital day 6, he developed lower extremity weakness that progressed to flaccid paralysis. Case 2: A 58-year-old male sustained a 9% TBSA high-voltage injury. On hospital day 2, he started to have progressive weakness of his lower extremities that progressed to flaccid paralysis. Neither case was judged to have experienced additional significant trauma. Neurological complications after electrical injuries are protean. Delayed spinal cord injury is rare and associated with variable degrees of recovery. Neurological follow-up with rehabilitation is essential for a successful recovery.
- Published
- 2020
29. Multiple Simultaneous Mature Teratomas of the Spinal Cord in an Adult
- Author
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Gaddum D Reddy, Michelle Dewitt, and Timothy E Richardson
- Subjects
Surgical resection ,medicine.medical_specialty ,Adult teratoma ,Neurosurgery ,030204 cardiovascular system & hematology ,law.invention ,Lesion ,Intramedullary rod ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Lower extremity weakness ,spinal teratoma ,mature teratoma ,Upper thoracic region ,adult teratoma ,business.industry ,General Engineering ,Spinal cord ,medicine.anatomical_structure ,Oncology ,Mature teratoma ,Radiology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,multiple teratoma - Abstract
Teratomas of the spinal cord are rare tumors, particularly in adults, but there is an increasing body of literature documenting both their diagnosis and successful treatment with surgical resection. However, to date, the literature has largely characterized spinal teratomas as single solitary lesions. Here, we report on an adult patient who presented with signs of progressive lower extremity weakness. Imaging demonstrated two simultaneous lesions of the spine, an extramedullary lesion in the upper thoracic region and an intramedullary lesion in the mid-thoracic region. Both lesions were resected and pathologically determined to be mature spinal teratomas. To our knowledge, this is only the second report of this tumor presenting simultaneously at more than one location in the spine and the first time it has presented both as an intra-axial and extra-axial lesion. Our results suggest that the presence of more than one simultaneous lesion does not necessarily increase the risk of a more aggressive immature pathology.
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- 2020
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30. Causes of lower extremity weaknesses after posterior lumbar spine fusion surgery and therapeutic effects of active surgical exploration
- Author
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Yu Wang, Chunde Li, Hai-lin Lu, Rui Wang, Xiaodong Yi, and Hong Li
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Male ,Reoperation ,musculoskeletal diseases ,medicine.medical_specialty ,Weakness ,Lower extremity weakness ,lcsh:Diseases of the musculoskeletal system ,Nerve root ,Decompression ,Lumbar spine fusion ,medicine.medical_treatment ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,lcsh:Orthopedic surgery ,medicine ,Humans ,Internal fixation ,Orthopedics and Sports Medicine ,Muscle Strength ,Aged ,030222 orthopedics ,Lumbar Vertebrae ,business.industry ,Therapeutic effect ,Posterior lumbar spine fusion surgery ,Middle Aged ,Hematoma, Epidural, Spinal ,Magnetic Resonance Imaging ,Internal Fixators ,Prosthesis Failure ,Surgery ,lcsh:RD701-811 ,Spinal Fusion ,Treatment Outcome ,Neurological complications ,Paraparesis, Spastic ,Orthopedic surgery ,Treatment strategy ,Female ,medicine.symptom ,lcsh:RC925-935 ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Background This study was aimed at investigating the causes of lower extremity weaknesses after posterior lumbar spine fusion surgery and looking at subsequent treatment strategies. Methods Patients who underwent posterior lumbar spine fusion surgery in the Peking University First Hospital between January 2009 and December 2018 were counted. Those who needed secondary surgery because of subsequent lower extremity weaknesses were selected. CT scans and MRIs were used to evaluate the reasons for weaknesses before secondary surgery. Muscle strength was evaluated after surgery. Results Thirty patients (30/4078, 0.74%) required a secondary surgery because of lower extremity weaknesses after posterior lumbar spine fusion surgery. The main causes of weakness were (1) internal fixation malposition and loosening (11 patients, 36%), (2) epidural hematomas (9 patients, 30%), (3) insufficient decompression (5 patients, 17%), and (4) nerve root edemas (5 patients, 17%). Weakness occurred on average 2.9 days after surgery (1–9 days). Twenty-seven patients (90%) got improved muscle strength after their secondary surgery. Conclusions Iatrogenic neurologic deficits and lower extremity weaknesses were rare complications after posterior lumbar spine fusion surgeries, but important to recognize and manage. The main causes of weakness were internal fixation malposition and loosening, epidural hematomas, insufficient decompression, or root edemas. There may be positive, therapeutic effects to subsequent, active surgical exploration.
- Published
- 2020
31. Thyrotoxic Periodic Paralysis: A Case Report and Literature Review
- Author
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Karim Ladak and Matthew Patel
- Subjects
Community and Home Care ,Weakness ,Pediatrics ,medicine.medical_specialty ,business.industry ,Graves' disease ,Thyrotoxic periodic paralysis ,Hypokalemia ,Case Report ,General Medicine ,Emergency department ,Disease ,Total body potassium ,medicine.disease ,Graves Disease ,Thyrotoxicosis ,medicine ,Potassium ,Lower extremity weakness ,Humans ,Paralysis ,medicine.symptom ,business - Abstract
Thyrotoxic periodic paralysis (TPP) is a rare presentation of thyrotoxicosis most commonly associated with Graves' disease. It is rare in Caucasians, but it affects approximately 2% of Asians (occurring in those of Chinese, Japanese, Vietnamese, Filipino, and Korean descent) with thyrotoxicosis of any cause. Typical thyrotoxic features may be absent despite biochemical thyrotoxicosis. Hypokalemia and muscle paralysis are the result of an acute intracellular shift of potassium and not due to total body potassium deficiency. TPP is a self-limiting condition that is easily corrected by treatment of the thyrotoxicosis. We present a case of a Filipino man, aged 47 years, who presented to the emergency department with acute bilateral lower extremity weakness and hypokalemia who was subsequently diagnosed with TPP due to Graves' disease.
- Published
- 2020
32. Lower Extremity Weakness and Numbness in the Postpartum Period
- Author
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Mary Angela O’Neal
- Subjects
03 medical and health sciences ,Pediatrics ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Incidence (epidemiology) ,Medicine ,Lower extremity weakness ,030212 general & internal medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Postpartum period - Abstract
This article reviews the common lower extremity postpartum neuropathies, including their incidence, risk factors, clinical features, and treatment. In addition, the rarer complications from neuraxial anesthesia are also discussed.
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- 2019
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33. Clinical Reasoning: A 59-year-old woman with multiple myeloma and lower extremity weakness and numbness
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Fábio A. Nascimento, Martha P. Mims, Karen Nunez-Wallace, and Ron Gadot
- Subjects
Weakness ,medicine.medical_specialty ,Polyradiculoneuropathy ,Sepsis ,Hypesthesia ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Lower extremity weakness ,Humans ,030212 general & internal medicine ,Multiple myeloma ,Dexamethasone ,Muscle Weakness ,business.industry ,Bortezomib ,Middle Aged ,medicine.disease ,Surgery ,Lower Extremity ,Saddle anesthesia ,Female ,Neurology (clinical) ,medicine.symptom ,Presentation (obstetrics) ,business ,Multiple Myeloma ,030217 neurology & neurosurgery ,medicine.drug - Abstract
A 59-year-old woman with a history of stage 3 immunoglobulin G (IgG) lambda multiple myeloma (MM) on treatment with bortezomib and dexamethasone, chronic lower back pain, and chronic but improving bilateral lower extremity weakness and numbness presented with 2 to 3 weeks of worsening lower extremity weakness and numbness. Prior to presentation, the patient had been hospitalized for sepsis and cardiac arrest. Weakness affected the left lower extremity before progressing to the right lower extremity, whereas numbness was present in both feet. There was no bowel or bladder incontinence, saddle anesthesia, preceding trauma, or history of radiation therapy. The bilateral lower extremity weakness and numbness resulted in gait impairment and falls, which prompted admission for further investigation. Notably, bortezomib had been started 4 months prior to presentation.
- Published
- 2020
34. Idiopathic localizing signs and atypical symptoms of cervical disk pathology: A case report
- Author
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William Clifton, Clarence B. Watridge, Kent R. Richter, Mark A. Pichelmann, and Jang W. Yoon
- Subjects
Male ,Weakness ,medicine.medical_specialty ,Disc herniation ,Anterior cervical discectomy and fusion ,Nerve root compression ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,medicine ,Humans ,Lower extremity weakness ,Paresthesia ,Radiculopathy ,Leg ,Muscle Weakness ,Leg weakness ,business.industry ,General Medicine ,Middle Aged ,Surgery ,Neurology ,030220 oncology & carcinogenesis ,Cervical Vertebrae ,Neurology (clinical) ,medicine.symptom ,Presentation (obstetrics) ,Cervical disc ,business ,Intervertebral Disc Displacement ,030217 neurology & neurosurgery ,Diskectomy - Abstract
Cervical disc herniations most often present with neck and arm pain resulting from direct nerve root compression from a paramedian or foraminal disc herniation. It is unusual to encounter unilateral lower extremity symptoms in the absence of other neurological symptoms due to a centrally herniated cervical disc. Because this clinical presentation is uncommon, there can be misdiagnosis, or delay in treatment of patients who suffer from debilitating pain or weakness. We treated a patient who presented with acute progressive unilateral lower extremity weakness and paresthesia from a large herniated cervical disk. His lower extremity symptoms resolved post-operatively after undergoing anterior cervical discectomy and fusion. This case provides an example of the importance of neuroanatomical knowledge in surgical decision-making; clinicians should recognize that unilateral leg weakness can result from cervical disc herniation in absence of other neurological symptoms.
- Published
- 2019
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35. Increasing Back and Radicular Pain 2 Years Following Intrathecal Pump Implantation with Review of Arachnoiditis.
- Author
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Kochany, Jacob Z., Tran, Nam D., and Sarria, Jose E.
- Subjects
- *
MENINGITIS diagnosis , *BACK , *DRUG infusion pumps , *LAMINECTOMY , *MAGNETIC resonance imaging , *MENINGITIS , *PAIN , *MUSCLE weakness , *SPINAL infusions - Abstract
Background Implanted intrathecal drug delivery pumps are now regularly used for the treatment of chronic benign and cancer-related pain that is refractory to conservative treatment methods. In most cases, the pumps are successful at reducing the intensity of pain and improving function and quality of life for pain patients. Limited studies have discussed the complications associated with intrathecal pump placement. Setting Academic tertiary care center. Summary We describe an unusual case of a patient who presented with progressive weakness and worsening lumbar and lower extremity pain following implantation of an intrathecal drug delivery system ( IDDS). Work-up for the patient's symptoms includes a magnetic resonance imaging, which revealed lumbar arachnoiditis. Patient underwent a laminectomy and detethering of spinal cord and nerve roots below level of catheter insertion. There was transient improvement in her pain and weakness. Subsequent surgery for pump explantation revealed a retained Touhy introducer needle from her pump placement procedure. Conclusion The entire IDDS was removed including the retained Touhy introducer needle. The patient later went on to receive a successful spinal cord stimulator trial and implantation with moderate relief of her chronic pain. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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36. Spondylolisthesis
- Author
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Ward, R., Heckman, James D., editor, Schenck, Robert C., Jr., editor, and Agarwal, Animesh, editor
- Published
- 2000
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37. Shaggy Aortic Score is Associated with Postoperative Lower Extremity Weakness after Branched Endovascular Aortic Aneurysm Repair
- Author
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Jade S. Hiramoto, Iris H. Liu, Linda M. Reilly, Cindy Huynh, Laura Menke, and Warren J. Gasper
- Subjects
medicine.medical_specialty ,Aortic aneurysm repair ,business.industry ,Medicine ,Lower extremity weakness ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2021
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38. 55-year-old Male with Bilateral Lower Extremity Weakness
- Author
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Anthony Roggio, Laura J Bontempo, Tejusve Rao, and Zachary D.W. Dezman
- Subjects
medicine.medical_specialty ,business.industry ,Emergency Medicine ,Physical therapy ,medicine ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Lower extremity weakness ,Clinicopathological Cases ,lcsh:RC86-88.9 ,Emergency Nursing ,business - Abstract
n/a
- Published
- 2017
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39. Acute Onset of Bilateral Lower Extremity Weakness and Unsteady Gait in a Toddler
- Author
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Bindiya Bagga, Price T Edwards, Diego R. Hijano, Ehab Dayyat, Ashley Kiefer, and Feenalie Patel
- Subjects
medicine.medical_specialty ,Unsteady gait ,Electromyography ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Acute onset ,030225 pediatrics ,medicine ,Humans ,Lower extremity weakness ,Gait disorders ,Toddler ,Gait Disorders, Neurologic ,Muscle Weakness ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Magnetic Resonance Imaging ,Tick Paralysis ,Tick-Borne Diseases ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,030217 neurology & neurosurgery - Published
- 2017
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40. Thorn in My Spine: A case of a retained intradural extramedullary foreign body
- Author
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Christie M. Lincoln, Pedro J. Diaz-Marchan, Peter N. Fata, Anthony Balzer, and Nakul Reddy
- Subjects
Male ,medicine.medical_specialty ,Thoracic spine ,Wounds, Penetrating ,Thoracic Vertebrae ,03 medical and health sciences ,0302 clinical medicine ,Extramedullary Involvement ,medicine ,Humans ,Lower extremity weakness ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Foreign Bodies ,business.industry ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Spinal Injuries ,Dura Mater ,Foreign body ,Tomography, X-Ray Computed ,business ,Intradural extramedullary ,030217 neurology & neurosurgery ,Foreign body granuloma - Abstract
Foreign bodies in the spine are most commonly traumatic and managed in an acute setting. A few case reports describe foreign bodies resulting in delayed neurologic dysfunction, most commonly iatrogenic or from penetrating injury. We present a 30-year old man with lower extremity weakness from an intradural extramedullary foreign body granuloma secondary to a thorn, which was initially thought to represent an aggressive malignant process with intra and extramedullary involvement on MR. Postoperatively, the patient endorsed a causative trauma several years prior. We also present a review of the few similar published cases as well as the described prototypical imaging features and pathologic process.
- Published
- 2017
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41. Rhabdomyolysis associated with laboratory-confirmed FUB-AMB use
- Author
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Roy Gerona and Stephen L. Thornton
- Subjects
biology ,business.industry ,Emergency department ,medicine.disease ,Lumbar ,Anesthesia ,Urine drug screen ,Back pain ,medicine ,biology.protein ,Lower extremity weakness ,Creatine kinase ,medicine.symptom ,business ,Rhabdomyolysis - Abstract
A 25-year-old female presented to an emergency department complaining of atraumatic back pain and lower extremity weakness. An extensive laboratory and radiographic evaluation, including thoracic and lumbar MRIs, demonstrated rhabdomyolysis. Her creatinine kinase peaked at 17,991 U/L. Upon further questions the patient admitted to using marijuana the night before but urine drug screen was negative for cannabinoids. Liquid chromatography—quadrupole time-of-flight mass spectrometry of her serum—detected methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate (AMB-FUBINACA or FUB-AMB) at a concentration of 4.2 ng/mL. No other cause of rhabdomyolysis was found. She improved with hydration and was discharged after a 3-day hospitalization.
- Published
- 2020
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42. Link between Hyperglycaemia, Insulin resistance, and Lower Extremity Weakness Following Complex Endovascular Aortic Aneurysm Repair
- Author
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Fabien Lareyre and Juliette Raffort
- Subjects
medicine.medical_specialty ,Aortic aneurysm repair ,business.industry ,medicine.disease ,Surgery ,Aortic Aneurysm ,Blood Vessel Prosthesis Implantation ,Insulin resistance ,Glucose ,Lower Extremity ,Hyperglycemia ,medicine ,Lower extremity weakness ,Humans ,Insulin Resistance ,Cardiology and Cardiovascular Medicine ,business - Published
- 2019
43. Continuous or intermittent? Which regiment of enteral nutrition is better for acute stroke patients? A systematic review and meta-analysis
- Author
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Fahmy W F Hanna, Julius Sim, Adam D Farmer, Elizabeth Twomlow, Christine Roffe, Joanne Lancaster, and Giovanni Di Paolo
- Subjects
Nonsteroidal ,business.industry ,RM930 ,Q1 ,R1 ,chemistry.chemical_compound ,Regimen ,medicine.anatomical_structure ,Parenteral nutrition ,chemistry ,RZ ,Anesthesia ,Meta-analysis ,medicine ,Back pain ,Sphincter ,Lower extremity weakness ,medicine.symptom ,business ,RA ,Acute stroke - Abstract
Background and purpose: Enteral nutrition via nasogastric tube in acute stroke patients with dysphagia is an important determinant of patient outcomes. It is unclear whether intermittent or continuous feeding is more efficacious. The aim of this review is to examine the current evidence comparing the effectiveness of intermittent versus continuous feeding in stroke patients in terms of nutritional status, gastrointestinal intolerance and other complications.\ud \ud Methods: A systematic review of randomized controlled studies comparing intermittent with continuous nasogastric feeding in acute stroke patients was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Metaanalyses) guidance using predefined search terms. The search was conducted in MEDLINE and EMBASE up to 1st March 2019. Two independent reviewers assessed study quality using the Joanna Briggs Institute Critical Appraisal Tool. Meta-analyses were conducted, where appropriate, using a random-effects model to pool risk ratio with corresponding 95% CI.\ud \ud Results: Three studies including a total of 184 patients were identified. All three were medium to low quality. The definition of intermittent enteral nutrition within each study varied considerably in terms of volume, rate and mode of delivery. Achievement of nutritional targets was the same for both feeding patterns in the one study it was reported. Only aspiration pneumonia and diarrhea were measured by all three studies. There was no significant difference in the incidence of aspiration pneumonia (RR 0.91, 95% CI 0.53-1.57, p=0.74, I2=50%) and diarrhea (RR 1.74, 95% CI 0.70-4.30, p=0.23, I2=42%) between the two patterns of feeding. Other outcomes including, vomiting, gastric retention, mortality, pre-albumin and nasogastric tube complications showed no significant differences.\ud \ud Conclusion: There is very little and low-quality evidence to inform patterns of enteral feeding after stroke. The available evidence shows no significant difference in nutritional achievement and complications between intermittent and continuous nasogastric tube feeding in acute stroke patients.
- Published
- 2019
44. A 69-year-old woman with double vision and lower-extremity weakness
- Author
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Ibrahim Migdady, Kerry H. Levin, and MaryAnn Mays
- Subjects
Weakness ,Pediatrics ,medicine.medical_specialty ,Ataxia ,genetic structures ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Central Nervous System Diseases ,medicine ,Diplopia ,Lower extremity weakness ,Humans ,030212 general & internal medicine ,Aged ,Muscle Weakness ,business.industry ,Sensory loss ,General Medicine ,eye diseases ,Lower Extremity ,Female ,medicine.symptom ,Waldenstrom Macroglobulinemia ,business ,Sudden onset - Abstract
A 69-year-old woman was admitted to the hospital with double vision, weakness in the lower extremities, sensory loss, pain, and falls. Her symptoms started with sudden onset of horizontal diplopia 6 weeks before, followed by gradually worsening lower-extremity weakness, as well as ataxia and patchy
- Published
- 2019
45. Autoimmune necrotizing myopathy after statin discontinuation
- Author
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Haisam Abid, Kanramon Watthanasuntorn, and Edward Bischof
- Subjects
medicine.medical_specialty ,Statin ,medicine.drug_class ,Electromyography ,Gastroenterology ,Autoimmune Diseases ,03 medical and health sciences ,Necrosis ,0302 clinical medicine ,Muscular Diseases ,Rare Disease ,Internal medicine ,medicine ,Lower extremity weakness ,Humans ,030212 general & internal medicine ,Myopathy ,Aged ,Muscle biopsy ,medicine.diagnostic_test ,business.industry ,General Medicine ,Statin treatment ,Autoimmune necrotizing myopathy ,Discontinuation ,Substance Withdrawal Syndrome ,Female ,medicine.symptom ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,030217 neurology & neurosurgery - Abstract
We report a case of autoimmune necrotizing myopathy related to statin use in a 70-year-old woman who came to the hospital because of progressive lower extremity weakness. Laboratory, electromyography and muscle biopsy results were consistent with autoimmune necrotising myopathy. The patient was treated with intravenous immunoglobulin with improvement in muscle strength.
- Published
- 2019
46. Spontaneous Multiloculated Lumbar Abscess in a Middle-Aged Male With Unexplained Progressive Back Pain and Muscle Weakness.
- Author
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Nyc MA, Francis L, and Woloski JR
- Abstract
A 54-year-old man with a past medical history significant for sciatica, as well as multiple orthopedic surgeries with hardware, was transferred from an outside rural facility for further workup of a two-month history of progressive back pain and muscle weakness. Investigations ultimately revealed abnormal enhancement from T11 to sacrum, with a large epidural abscess from L5 to the sacrum, best visualized on an MRI. Following the MRI confirmation of loculated complex thoracolumbar abscess, neurosurgery performed a left L3-S1 unilateral laminotomy and evacuation of compressive multiloculated epidural abscesses. The patient was then treated with empirical antimicrobial coverage for epidural abscess with vancomycin and ceftriaxone, which was narrowed to cefazolin based on positive methicillin-susceptible Staphylococcus aureus (MSSA) wound cultures obtained in the operating room. The patient completed a total six-week course of antibiotic therapy. Apart from some superficial wound dehiscence postoperative, the patient ultimately recovered well and had a resolution of most presenting symptoms., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Nyc et al.)
- Published
- 2022
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47. Effective Motor Evoked Potential Waveforms in Patients with Lower Extremity Weakness
- Author
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Sang-Ku Park, Sung-Hyuk Lim, and Hung-Tae Han
- Subjects
03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Physical medicine and rehabilitation ,030202 anesthesiology ,business.industry ,Medicine ,Lower extremity weakness ,In patient ,Evoked potential ,business ,030217 neurology & neurosurgery - Published
- 2016
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48. Management of presacral retroperitoneal schwannoma: highlighting the various features
- Author
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Sandeep P. Murumkar, Sanjay P Dhangar, Nitin Baste, and Manisha Shengal
- Subjects
Sciatica ,medicine.medical_specialty ,Retroperitoneal schwannoma ,Constipation ,business.industry ,Urinary system ,Schwannoma ,medicine.disease ,Blood loss ,Radiological weapon ,medicine ,Lower extremity weakness ,Radiology ,medicine.symptom ,business - Abstract
Schwannomas are relatively rare tumours. They occur in approximately 1 of 40,000 hospital admissions. Usually asymptomatic unless very big in size. They may present with symptoms of visceral compression viz. constipation, urinary frequency and urgency, or the nerve compression like sciatica, lower extremity weakness, tingling and numbness. We here highlight the various clinical, radiological and pathologic features the tumour and importance of proper pre-operative imaging, planning regarding surgery and the type of consent required before the surgery in a 30 years old male with a large pelvic mass, diagnosed and supposed to be Schwannoma arising from the S2 sacral foramina. We were able to enucleate the mass intact without any visceral or neuro-vascular injury with minimal blood loss.
- Published
- 2020
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49. Teaching NeuroImages: Not a typical spinal mass
- Author
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Sejal M Shah, Michelle J. Clarke, Elizabeth A. Coon, Amy A. Swanson, Tarun D. Singh, Anthony M. Burrows, and Farwa Ali
- Subjects
medicine.medical_specialty ,Magnetic resonance angiography ,law.invention ,Intramedullary rod ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,law ,medicine ,Lower extremity weakness ,Humans ,Spasticity ,Muscle Weakness ,Spinal Neoplasms ,medicine.diagnostic_test ,business.industry ,Cysts ,Thoracic spine MRI ,Epidermoid cyst ,medicine.disease ,Gross Total Resection ,Magnetic Resonance Imaging ,Muscle Spasticity ,030220 oncology & carcinogenesis ,Female ,Neurology (clinical) ,Radiology ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
A 20-year-old woman presented with subacute progressive lower extremity weakness and spasticity. Examination findings were consistent with Brown-Sequard syndrome. Thoracic spine MRI/magnetic resonance angiography showed an intramedullary mass (figure 1). During gross total resection, the mass had a pearlescent appearance, while histopathologic examination was consistent with epidermoid cyst (figure 2).
- Published
- 2018
50. Transcranial motor-evoked potentials for prediction of postoperative neurologic and motor deficit following surgery for thoracolumbar scoliosis
- Author
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Jason T. Machan, Sean W Donegan, Teena Shetty, Niesha Voigt, Alan H Daniels, Adam E.M. Eltorai, Samuel M. Miller, and Joseph T. Nguyen
- Subjects
Orthopedic surgery ,030222 orthopedics ,Retrospective review ,medicine.medical_specialty ,Adductor hallucis ,business.industry ,thoracolumbar scoliosis ,Thoracolumbar scoliosis ,postoperative neurologic deficit ,Article ,Scoliosis surgery ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,motor-evoked potential ,Peroneus longus ,Medicine ,Lower extremity weakness ,Orthopedics and Sports Medicine ,Motor evoked potential ,business ,Motor Deficit ,RD701-811 ,030217 neurology & neurosurgery - Abstract
Transcranial motor-evoked potentials (TcMEPs) are used to monitor the descending motor pathway during scoliosis surgery. By comparing potentials before and after correction, surgeons may prevent postoperative functional loss in distal muscles. There is currently no consensus as to which muscles should be monitored. The purpose of this study is to determine the least invasive monitoring protocol with the best localization of potential neurologic deficit. A retrospective review of 125 patients with TcMEP monitoring during surgery for thoracolumbar scoliosis between 2008 and 2015 was conducted. 18 patients had postoperative neurologic consult due to deficit. The remaining 107 patients were a consecutive cohort without postoperative neurologic consult. TcMEPs were recorded from vastus lateralis (VL), tibialis anterior (TA), peroneus longus (PL), adductor hallucis (AH) and abductor pollicis brevis (APB) bilaterally. The effectiveness of each muscle combination was evaluated independently and then compared to other combinations using Akaike Information Criterion (AIC). Monitoring of VL, TA, PL, and AH yielded sensitivity of 77.8% and specificity of 92.5% (AIC=66.7). Monitoring of TA, PL and AH yielded sensitivity of 77.8% and specificity of 94.4% (AIC=62.4). Monitoring of VL, TA and PL yielded sensitivity of 72.2% and specificity of 93.5% (AIC=70.1). Monitoring of TA and PL yielded sensitivity of 72.2% and specificity of 96.3% (AIC=63.9). TcMEP monitoring of TA, PL, and AH provided the highest sensitivity and specificity and best predictive power for postoperative lower extremity weakness.
- Published
- 2018
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