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1. A retrospective analysis of outcomes and complications of living- and deceased-donor split-liver transplantation in Johannesburg, South Africa

Author

Crawford, R, primary, Loveland, J, additional, Gaylard, P, additional, Fabian, J, additional, Kinandu, K, additional, Bobat, B, additional, Mahomed, A, additional, Parbhoo, D, additional, Beretta, M, additional, Berkenfeld, S, additional, Rambarran, S, additional, Van der Schyff, F, additional, Brannigan, L, additional, and Strobele, B, additional

Published
2024
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3. The paediatric liver transplant experience in Johannesburg, South Africa: A broad overview and update

Author

Kinandu, K, primary, Beeton, A, additional, Beretta, M, additional, Berkenfeld, S, additional, Brannigan, L, additional, Britz, R, additional, Demopoulos, D, additional, Doedens, L, additional, Duncan, M, additional, Gaylard, P, additional, Hajinicolaou, C, additional, Lowman, W, additional, Maher, H, additional, De Maayer, T, additional, Mudau, V, additional, Rambarran, S, additional, Reynders, M, additional, van der Schyff, F, additional, Ströbele, B, additional, Tager, S, additional, Wessels, E, additional, Fabian, J, additional, and Loveland, J, additional

Published
2024
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4. ABO-incompatible liver transplantation – exploring utilitarian solutions to restricted access and organ shortages: A single-centre experience from Johannesburg, South Africa

Author

Wessels, E U, primary, Loveland, J, additional, Maher, H, additional, Gaylard, P, additional, Bobat, B, additional, Mahomed, A D, additional, Parbhoo, D, additional, Beretta, M R, additional, Hajinicolaou, C, additional, Walabh, P, additional, Berkenfeld, S, additional, Demopoulos, D, additional, Rambarran, S, additional, Ströbele, B, additional, Van der Schyff, F, additional, Fabian, J, additional, and Brannigan, L, additional

Published
2024
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7. Responding to the need: An evaluation of the subspecialty units in a pediatric surgical department in a limited resource setting using selected optimal resources for children's surgery strategies.

Author

Govender, T. R., Scribante, J., Govender, T., Withers, A., and Loveland, J. A.

Subjects
PEDIATRIC surgery, RESOURCE-limited settings, MIDDLE-income countries, LOW-income countries, SURGICAL clinics, UROLOGY
Abstract

Background: The Global Initiative for Children's Surgery group published the Optimal Resources for Children's Surgery (OReCS) document outlining the essential criteria and strategies for children's surgical care in low‐resource settings. Limited data exist on subspecialties in pediatric surgery and their contribution to global surgery efforts. The study aimed to evaluate the development of subspecialty units within Chris Hani Baragwanath Academic Hospital (CHBAH) Department of Pediatric Surgery (DPS) from January 1, 2018 to December 31, 2021 using selected OReCS strategies for the improvement of pediatric surgery. Methods: A retrospective descriptive research design was followed. The study population consisted of CHBAH PSD records. The following data were collected: number of patients managed in PSD subspecialty unit (the units) clinics and surgeries performed, number of trainees, available structures, processes and outcome data, and research output. Results: Of the 17,249 patients seen in the units' outpatient clinics, 8275 (47.9%) burns, 6443 (37.3%) colorectal, and 2531 (14.6%) urology. The number of surgeries performed were 3205, of which 1306 (40.7%) were burns, 644 (20.1%) colorectal, 483 (15.1%) urology, 341 (10.6%) hepatobiliary, and 431 (12.8%) oncology. Of the 16 selected strategies evaluated across the 5 units, 94% were available, of which 16.4% was partly provided by Surgeons for Little Lives. Outcome data in the form of morbidity and mortality reviews for all the units is available, but there is no data for timeliness of care with waiting lists. There were 77 publications and 41 congress presentations. Conclusion: The subspecialty units respond to the global surgical need by meeting most selected OReCS resources in the clinical service provided. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Clinical evaluation and outcomes in children ≤10 years old involved in road traffic accidents, presenting to Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa

Author

Carreira, J-A, Kruger, D, and Loveland, J

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Background. Road traffic accidents (RTAs) are a leading cause of injury and death globally, particularly among children. Pedestrians are most often injured, especially in middle- and low-income countries. The epidemiology, patterns and severity of injuries in children involved in RTAs in our community are hard to obtain.Objectives. To evaluate the aetiological spectrum, injury characteristics and treatment outcomes of paediatric patients involved in RTAs, who presented to Chris Hani Baragwanath Academic Hospital (CHBAH), a tertiary hospital in Soweto, South Africa. Methods. Patients ≤10 years old, who were involved in RTAs and seen at CHBAH, were included in the study.Results. The study was conducted from 20 August 2017 to 31 March 2018, and included the data of 156 patients. Their ages ranged from 13 days to 10 years (65% were boys). Pedestrian vehicle accidents accounted for 78.8% of the injuries, with 60.8% of the children being unaccompanied by an adult. Motor vehicle accidents accounted for 19.2% of the injuries, with 92% of the children being unrestrained in the vehicle. Of the patients, 73.2% (n=112/153) underwent radiography and 44.4% required computed tomography (CT) scans, the majority being CT scans of the brain for suspected head injuries. Soft-tissue injuries accounted for 78.9% of cases, followed mainly by head (39.7%) and limb (16%) injuries. Only 12% of patients required surgical intervention, with 42% of the operations being for orthopaedic injuries.Conclusion. The abovementioned data demonstrate that there is a lack of use of child restraints for children travelling as passengers in vehicles, and inadequate supervision of children on and around roads. This study supports other evidence, as it suggests that the paediatric population involved in RTAs is largely injured as pedestrians, and that males tend to be involved in more RTAs than females. The majority of injuries sustained involved the soft tissues, followed by head injuries.

Published
2022
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13. A surgeon’s dress code – the patients’ perspective

Author

Pswarayi, R, Jugmohan, B, Devar, JWS, and Loveland, J

Subjects
dress code, attire, clothing, doctor wear
Abstract

Background: The dress code for surgeons has evolved over time from formal suit-and-tie to crisp white coat, and currently to various forms of smart-casual attire; however, there is no stipulated or rigid uniform guideline. It is important to explore and discuss the various forms of attire in relation to patients’ ideals and perceptions of a surgeon.Methods: An observational study in the form of a paper-based questionnaire was carried out at the Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), Chris Hani Baragwanath Academic Hospital (CHBAH) and Wits Donald Gordon Medical Centre (WDGMC). Seven questions (Q1–Q7) were posed with various dress categories to select from in each question, namely: formal, smart, smart-casual and scrubs. Descriptive analysis of the survey responses, and the determination of the association between survey responses and a) hospital, b) gender, c) age group was performed. Fisher’s exact test was used where the requirements for the chi-square test could not be met. Attire groups with n < 15 were not analysed. The strength of the associations was measured by Cramer’s V and the phi coefficient respectively. Data analysis was carried out using SAS v9.4 for Windows. A 5% significance level was used.Results: A total of 387 questionnaires were filled out with a total of 376 fully completed and eligible samples in consenting participants of 18 years and older. In all seven questions, scrubs were the preferred attire. Overall, for Q1–Q5 and Q7, after scrubs, smart was the next most popular attire. For Q6, after scrubs, smart, smart-casual and formal were all popular, indicating some leeway on weekends and public holidays. There was a significant association between each of the responses to the question and hospital (p < 0.0001). At CHBAH, patients preferred scrubs more and smart attire less, compared to CMJAH and WDGMC. At CMJAH, preference for formal attire was greater when compared to the other two hospitals.Conclusion: Overall, patients preferred their surgeons to be dressed in scrubs as this attire easily identified surgeons and instilled confidence in the wearer.

Published
2023

15. Rectal suction biopsies to diagnose Hirschsprung's disease in a low-resource environment - optimising cost-effectiveness

Author

Hartford, L, Schönfeldt, N, Mohanlal, R, Bebington, C, Loveland, J, Westgarth-Taylor, C, and Brisighelli, G

Subjects
rectal suction biopsy, rectal biopsy, Hirschsprung's disease
Abstract

BACKGROUND: The diagnosis of Hirschsprung's disease (HD) by rectal suction biopsy (RSB) has cost implications that could be reduced by ascertaining the optimal number of specimens required. The aim was to audit our experience to optimise cost-effectiveness METHODS: Medical records of all patients who underwent an RSB between January 2018 and December 2021 were reviewed. In 2020, we transitioned from using the Solo-RBT to the rbi2 system (requiring single-use cartridges). Descriptive statistics were reported and a comparative analysis of the diagnostic efficacy of the Solo-RBT versus the rbi2 system was performed. The cost of consumables was calculated according to the number of specimens submitted RESULTS: Of 218 RSBs, 181 were first and 37 were repeat. The mean age at biopsy was 62 days (IQR 22-65). An average of two tissue specimens were obtained per biopsy. Of the 181 first biopsies, 151 were optimal and 30 suboptimal. HD was confirmed in 19 (10.5%) of the patients. Amongst biopsies where a single specimen was obtained, 16% were inconclusive, compared to 14% with two specimens and 5% with three specimens. The cartridges for the rbi2 system cost R530. If two cartridges are used at initial biopsy the total cost is double of a single tissue specimen sent for initial biopsy, and two specimens sent for repeat biopsies CONCLUSION: In a low-resource setting, selecting the appropriate RSB system and obtaining a single specimen is sufficient to diagnose HD. Patients with inconclusive results should undergo a repeat biopsy where two specimens are obtained

Published
2023

19. Similarities and differences in allocation policies for pediatric liver transplantation across the world

Author

Fischler, B, Baumann, U, D'Agostino, D, D'Antiga, L, Dezsofi, A, Debray, D, Durmaz, O, Evans, H, Frauca, E, Hadzic, N, Jahnel, J, Loveland, J, Mclin, V, Ng, V, Nobili, V, Pawłowska, J, Sharif, K, Smets, F, Verkade, H, Hsu, E, Horslen, S, Bucuvalas, J, Fischler B., Baumann U., D'Agostino D., D'Antiga L., Dezsofi A., Debray D., Durmaz O., Evans H., Frauca E., Hadzic N., Jahnel J., Loveland J., McLin V., Ng V. L., Nobili V., Pawłowska J., Sharif K., Smets F., Verkade H. J., Hsu E., Horslen S., Bucuvalas J., Fischler, B, Baumann, U, D'Agostino, D, D'Antiga, L, Dezsofi, A, Debray, D, Durmaz, O, Evans, H, Frauca, E, Hadzic, N, Jahnel, J, Loveland, J, Mclin, V, Ng, V, Nobili, V, Pawłowska, J, Sharif, K, Smets, F, Verkade, H, Hsu, E, Horslen, S, Bucuvalas, J, Fischler B., Baumann U., D'Agostino D., D'Antiga L., Dezsofi A., Debray D., Durmaz O., Evans H., Frauca E., Hadzic N., Jahnel J., Loveland J., McLin V., Ng V. L., Nobili V., Pawłowska J., Sharif K., Smets F., Verkade H. J., Hsu E., Horslen S., and Bucuvalas J.

Abstract

Objectives:We aimed to investigate national allocation policies for pediatric liver transplantation (LT).Method:A survey was prepared by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Hepatology Committee in collaboration with the North American Studies of Pediatric Liver Transplantation consortium. The survey was sent to pediatric hepatologists and transplant surgeons worldwide. National data were obtained from centrally based registries.Results:Replies were obtained from 15 countries from 5 of the world continents. Overall donation rate varied between 9 and 35 per million inhabitants. The number of pediatric LTs was 4 to 9 per million inhabitants younger than 18 years for 13 of the 15 respondents. In children younger than 2 years mortality on the waiting list (WL) varied between 0 and 20%. In the same age group, there were large differences in the ratio of living donor LT to deceased donor LT and in the ratio of split liver segments to whole liver. These differences were associated with possible discrepancies in WL mortality.Conclusions:Similarities but also differences between countries were detected. The described data may be of importance when trying to reduce WL mortality in the youngest children.

Published
2019

21. Clinical evaluation and outcomes in children =10 years old involved in road traffic accidents, presenting to Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Author

Carreira, J.-A., Kruger, D., and Loveland, J.

Subjects
TRAFFIC accidents, CHILD patients, PEDESTRIAN accidents, HELMETS, HEAD injuries, LOW-income countries
Abstract

Background. Road traffic accidents (RTAs) are a leading cause of injury and death globally, particularly among children. Pedestrians are most often injured, especially in middle- and low-income countries. The epidemiology, patterns and severity of injuries in children involved in RTAs in our community are hard to obtain. Objectives. To evaluate the aetiological spectrum, injury characteristics and treatment outcomes of paediatric patients involved in RTAs, who presented to Chris Hani Baragwanath Academic Hospital (CHBAH), a tertiary hospital in Soweto, South Africa. Methods. Patients =10 years old, who were involved in RTAs and seen at CHBAH, were included in the study. Results. The study was conducted from 20 August 2017 to 31 March 2018, and included the data of 156 patients. Their ages ranged from 13 days to 10 years (65% were boys). Pedestrian vehicle accidents accounted for 78.8% of the injuries, with 60.8% of the children being unaccompanied by an adult. Motor vehicle accidents accounted for 19.2% of the injuries, with 92% of the children being unrestrained in the vehicle. Of the patients, 73.2% (n=112/153) underwent radiography and 44.4% required computed tomography (CT) scans, the majority being CT scans of the brain for suspected head injuries. Soft-tissue injuries accounted for 78.9% of cases, followed mainly by head (39.7%) and limb (16%) injuries. Only 12% of patients required surgical intervention, with 42% of the operations being for orthopaedic injuries. Conclusion. The abovementioned data demonstrate that there is a lack of use of child restraints for children travelling as passengers in vehicles, and inadequate supervision of children on and around roads. This study supports other evidence, as it suggests that the paediatric population involved in RTAs is largely injured as pedestrians, and that males tend to be involved in more RTAs than females. The majority of injuries sustained involved the soft tissues, followed by head injuries. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Malrotation and Volvulus

Author

Loveland, J., Dekker, G., Andronikou, Savvas, editor, Alexander, Angus, editor, Kilborn, Tracy, editor, Millar, Alastair J. W., editor, and Daneman, Alan, editor

Published
2010
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28. Horseshoe Kidney

Author

Loveland, J., von Bezing, H., Andronikou, Savvas, editor, Alexander, Angus, editor, Kilborn, Tracy, editor, Millar, Alastair J. W., editor, and Daneman, Alan, editor

Published
2010
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29. Gastro-Oesophageal Reflux

Author

Loveland, J., Greyling, P. J., Andronikou, Savvas, editor, Alexander, Angus, editor, Kilborn, Tracy, editor, Millar, Alastair J. W., editor, and Daneman, Alan, editor

Published
2010
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30. Empyema

Author

Loveland, J., van der Merwe, D. J., Andronikou, Savvas, editor, Alexander, Angus, editor, Kilborn, Tracy, editor, Millar, Alastair J. W., editor, and Daneman, Alan, editor

Published
2010
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32. The DNA sequence and biological annotation of human chromosome 1

Author

Gregory, S. G., Barlow, K. F., McLay, K. E., Kaul, R., Swarbreck, D., Dunham, A., Scott, C. E., Howe, K. L., Woodfine, K., Spencer, C. C. A., Jones, M. C., Gillson, C., Searle, S., Zhou, Y., Kokocinski, F., McDonald, L., Evans, R., Phillips, K., Atkinson, A., Cooper, R., Jones, C., Hall, R. E., Andrews, T. D., Lloyd, C., Ainscough, R., Almeida, J. P., Ambrose, K. D., Anderson, F., Andrew, R. W., Ashwell, R. I. S., Aubin, K., Babbage, A. K., Bagguley, C. L., Bailey, J., Beasley, H., Bethel, G., Bird, C. P., Bray-Allen, S., Brown, J. Y., Brown, A. J., Buckley, D., Burton, J., Bye, J., Carder, C., Chapman, J. C., Clark, S. Y., Clarke, G., Clee, C., Cobley, V., Collier, R. E., Corby, N., Coville, G. J., Davies, J., Deadman, R., Dunn, M., Earthrowl, M., Ellington, A. G., Errington, H., Frankish, A., Frankland, J., French, L., Garner, P., Garnett, J., Gay, L., Ghori, M. R. J., Gibson, R., Gilby, L. M., Gillett, W., Glithero, R. J., Grafham, D. V., Griffiths, C., Griffiths-Jones, S., Grocock, R., Hammond, S., Harrison, E. S. I., Hart, E., Haugen, E., Heath, P. D., Holmes, S., Holt, K., Howden, P. J., Hunt, A. R., Hunt, S. E., Hunter, G., Isherwood, J., James, R., Johnson, C., Johnson, D., Joy, A., Kay, M., Kershaw, J. K., Kibukawa, M., Kimberley, A. M., King, A., Knights, A. J., Lad, H., Laird, G., Lawlor, S., Leongamornlert, D. A., Lloyd, D. M., Loveland, J., Lovell, J., Lush, M. J., Lyne, R., Martin, S., Mashreghi-Mohammadi, M., Matthews, L., Matthews, N. S. W., McLaren, S., Milne, S., Mistry, S., Nickerson, T., O'Dell, C. N., Oliver, K., Palmeiri, A., Palmer, S. A., Parker, A., Patel, D., Pearce, A. V., Peck, A. I., Pelan, S., Phelps, K., Phillimore, B. J., Plumb, R., Rajan, J., Raymond, C., Rouse, G., Saenphimmachak, C., Sehra, H. K., Sheridan, E., Shownkeen, R., Sims, S., Skuce, C. D., Smith, M., Steward, C., Subramanian, S., Sycamore, N., Tracey, A., Tromans, A., Van Helmond, Z., Wall, M., Wallis, J. M., White, S., Whitehead, S. L., Wilkinson, J. E., Willey, D. L., Williams, H., Wilming, L., Wray, P. W., Wu, Z., Coulson, A., Vaudin, M., Sulston, J. E., Durbin, R., Hubbard, T., Wooster, R., Dunham, I., Carter, N. P., McVean, G., Ross, M. T., Harrow, J., Olson, M. V., Beck, S., Rogers, J., and Bentley, D. R.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): S. G. Gregory (corresponding author) [1, 2]; K. F. Barlow [1]; K. E. McLay [1]; R. Kaul [3]; D. Swarbreck [1]; A. Dunham [1]; C. E. Scott [1]; K. [...]

Published
2006
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34. The DNA sequence and analysis of human chromosome 13

Author

Dunham, A., Matthews, L. H., Burton, J., Ashurst, J. L., Howe, K. L., Ashcroft, K. J., Beare, D. M., Burford, D. C., Hunt, S. E., Griffiths-Jones, S., Jones, M. C., Keenan, S. J., Oliver, K., Scott, C. E., Ainscough, R., Almeida, J. P., Ambrose, K. D., Andrews, D. T., Ashwell, R. I. S., Babbage, A. K., Bagguley, C. L., Bailey, J., Bannerjee, R., Barlow, K. F., Bates, K., Beasley, H., Bird, C. P., Bray-Allen, S., Brown, A. J., Brown, J. Y., Burrill, W., Carder, C., Carter, N. P., Chapman, J. C., Clamp, M. E., Clark, S. Y., Clarke, G., Clee, C. M., Clegg, S. C. M., Cobley, V., Collins, J. E., Corby, N., Coville, G. J., Deloukas, P., Dhami, P., Dunham, I., Dunn, M., Earthrowl, M. E., Ellington, A. G., Faulkner, L., Frankish, A. G., Frankland, J., French, L., Garner, P., Garnett, J., Gilbert, J. G. R., Gilson, C. J., Ghori, J., Grafham, D. V., Gribble, S. M., Griffiths, C., Hall, R. E., Hammond, S., Harley, J. L., Hart, E. A., Heath, P. D., Howden, P. J., Huckle, E. J., Hunt, P. J., Hunt, A. R., Johnson, C., Johnson, D., Kay, M., Kimberley, A. M., King, A., Laird, G. K., Langford, C. J., Lawlor, S., Leongamornlert, D. A., Lloyd, D. M., Lloyd, C., Loveland, J. E., Lovell, J., Martin, S., Mashreghi-Mohammadi, M., McLaren, S. J., McMurray, A., Milne, S., Moore, M. J. F., Nickerson, T., Palmer, S. A., Pearce, A. V., Peck, A. I., Pelan, S., Phillimore, B., Porter, K. M., Rice, C. M., Searle, S., Sehra, H. K., Shownkeen, R., Skuce, C. D., Smith, M., Steward, C. A., Sycamore, N., Tester, J., Thomas, D. W., Tracey, A., Tromans, A., Tubby, B., Wall, M., Wallis, J. M., West, A. P., Whitehead, S. L., Willey, D. L., Wilming, L., Wray, P. W., Wright, M. W., Young, L., Coulson, A., Durbin, R., Hubbard, T., Sulston, J. E., Beck, S., Bentley, D. R., Rogers, J., and Ross, M. T.

Published
2004
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36. DNA sequence and analysis of human chromosome 9

Author

Humphray, S. J., Oliver, K., Hunt, A. R., Plumb, R. W., Loveland, J. E., Howe, K. L., Andrews, T. D., Searle, S., Hunt, S. E., Scott, C. E., Jones, M. C., Ainscough, R., Almeida, J. P., Ambrose, K. D., Ashwell, R. I. S., Babbage, A. K., Babbage, S., Bagguley, C. L., Bailey, J., Banerjee, R., Barker, D. J., Barlow, K. F., Bates, K., Beasley, H., Beasley, O., Bird, C. P., Bray-Allen, S., Brown, A. J., Brown, J. Y., Burford, D., Burrill, W., Burton, J., Carder, C., Carter, N. P., Chapman, J. C., Chen, Y., Clarke, G., Clark, S. Y., Clee, C. M., Clegg, S., Collier, R. E., Corby, N., Crosier, M., Cummings, A. T., Davies, J., Dhami, P., Dunn, M., Dutta, I., Dyer, L. W., Earthrowl, M. E., Faulkner, L., Fleming, C. J., Frankish, A., Frankland, J. A., French, L., Fricker, D. G., Garner, P., Garnett, J., Ghori, J., Gilbert, J. G. R., Glison, C., Grafham, D. V., Gribble, S., Griffiths, C., Griffiths-Jones, S., Grocock, R., Guy, J., Hall, R. E., Hammond, S., Harley, J. L., Harrison, E. S. I., Hart, E. A., Heath, P. D., Henderson, C. D., Hopkins, B. L., Howard, P. J., Howden, P. J., Huckle, E., Johnson, C., Johnson, D., Joy, A. A., Kay, M., Keenan, S., Kershaw, J. K., Kimberley, A. M., King, A., Knights, A., Laird, G. K., Langford, C., Lawlor, S., Leongamornlert, D. A., Leversha, M., Lloyd, C., Lloyd, D. M., Lovell, J., Martin, S., Mashreghi-Mohammadi, M., Matthews, L., McLaren, S., McLay, K. E., McMurray, A., Milne, S., Nickerson, T., Nisbett, J., Nordsiek, G., Pearce, A. V., Peck, A. I., Porter, K. M., Pandian, R., Pelan, S., Phillimore, B., Povey, S., Ramsey, Y., Rand, V., Scharfe, M., Sehra, H. K., Shownkeen, R., Sims, S. K., Skuce, C. D., Smith, M., Steward, C. A., Swarbreck, D., Sycamore, N., Tester, J., Thorpe, A., Tracey, A., Tromans, A., Thomas, D. W., Wall, M., Wallis, J. M., West, A. P., Whitehead, S. L., Willey, D. L., Williams, S. A., Wilming, L., Wray, P. W., Young, L., Ashurst, J. L., Coulson, A., Blocker, H., Durbin, R., Sulston, J. E., Hubbard, T., Jackson, M. J., Bentley, D. R., Beck, S., Rogers, J., and Dunham, I.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): S. J. Humphray (corresponding author) [1]; K. Oliver [1]; A. R. Hunt [1]; R. W. Plumb [1]; J. E. Loveland [1]; K. L. Howe [1]; T. D. Andrews [1]; [...]

Published
2004
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37. The DNA sequence and comparative analysis of human chromosome 10

Author

Deloukas, P., Earthrowl, M. E., Grafham, D. V., Rubenfield, M., French, L., Steward, C. A., Sims, S. K., Jones, M. C., Searle, S., Scott, C., Howe, K., Hunt, S. E., Andrews, T. D., Gilbert, J. G. R., Swarbreck, D., Ashurst, J. L., Taylor, A., Battles, J., Bird, C. P., Ainscough, R., Almeida, J. P., Ashwell, R. I. S., Ambrose, K. D., Babbage, A. K., Bagguley, C. L., Bailey, J., Banerjee, R., Bates, K., Beasley, H., Bray-Allen, S., Brown, A. J., Brown, J. Y., Burford, D. C., Burrill, W., Burton, J., Cahill, P., Camire, D., Carter, N. P., Chapman, J. C., Clark, S. Y., Clarke, G., Clee, C. M., Clegg, S., Corby, N., Coulson, A., Dhami, P., Dutta, I., Dunn, M., Faulkner, L., Frankish, A., Frankland, J. A., Garner, P., Garnett, J., Gribble, S., Griffiths, C., Grocock, R., Gustafson, E., Hammond, S., Harley, J. L., Hart, E., Heath, P. D., Ho, T. P., Hopkins, B., Horne, J., Howden, P. J., Huckle, E., Hynds, C., Johnson, C., Johnson, D., Kana, A., Kay, M., Kimberley, A. M., Kershaw, J. K., Kokkinaki, M., Laird, G. K., Lawlor, S., Lee, H. M., Leongamornlert, D. A., Laird, G., Lloyd, C., Lloyd, D. M., Loveland, J., Lovell, J., McLaren, S., McLay, K. E., McMurray, A., Mashreghi-Mohammadi, M., Matthews, L., Milne, S., Nickerson, T., Nguyen, M., Overton-Larty, E., Palmer, S. A., Pearce, A. V., Peck, A. I., Pelan, S., Phillimore, B., Porter, K., Rice, C. M., Rogosin, A., Ross, M. T., Sarafidou, T., Sehra, H. K., Shownkeen, R., Skuce, C. D., Smith, M., Standring, L., Sycamore, N., Tester, J., Thorpe, A., Torcasso, W., Tracey, A., Tromans, A., Tsolas, J., Wall, M., Walsh, J., Wang, H., Weinstock, K., West, A. P., Willey, D. L., Whitehead, S. L., Wilming, L., Wray, P. W., Young, L., Chen, Y., Lovering, R. C., Moschonas, N. K., Siebert, R., Fechtel, K., Bentley, D., Durbin, R., Hubbard, T., Doucette-Stamm, L., Beck, S., Smith, D. R., and Rogers, J.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): P. Deloukas (corresponding author) [1]; M. E. Earthrowl [1]; D. V. Grafham [1]; M. Rubenfield [2, 3]; L. French [1]; C. A. Steward [1]; S. K. Sims [1]; M. [...]

Published
2004
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38. The DNA sequence and analysis of human chromosome 6

Author

Mungall, A. J., Palmer, S. A., Sims, S. K., Edwards, C. A., Ashurst, J. L., Wilming, L., Jones, M. C., Horton, R., Hunt, S. E., Scott, C. E., Gilbert, J. G. R., Clamp, M. E., Bethel, G., Milne, S., Ainscough, R., Almeida, J. P., Ambrose, K. D., Andrews, T. D., Ashwell, R. I. S., Babbage, A. K., Bagguley, C. L., Bailey, J., Banerjee, R., Barker, D. J., Barlow, K. F., Bates, K., Beare, D. M., Beasley, H., Beasley, O., Bird, C. P., Blakey, S., Bray-Allen, S., Brook, J., Brown, A. J., Brown, J. Y., Burford, D. C., Burrill, W., Burton, J., Carder, C., Carter, N. P., Chapman, J. C., Clark, S. Y., Clark, G., Clee, C. M., Clegg, S., Cobley, V., Collier, R. E., Collins, J. E., Colman, L. K., Corby, N. R., Coville, G. J., Culley, K. M., Dhami, P., Davies, J., Dunn, M., Earthrowl, M. E., Ellington, A. E., Evans, K. A., Faulkner, L., Francis, M. D., Frankish, A., Frankland, J., French, L., Garner, P., Garnett, J., Ghori, M. J. R., Gilby, L. M., Gillson, C. J., Glithero, R. J., Grafham, D. V., Grant, M., Gribble, S., Griffiths, C., Griffiths, M., Hall, R., Halls, K. S., Hammond, S., Harley, J. L., Hart, E. A., Heath, P. D., Heathcott, R., Holmes, S. J., Howden, P. J., Howe, K. L., Howell, G. R., Huckle, E., Humphray, S. J., Humphries, M. D., Hunt, A. R., Johnson, C. M., Joy, A. A., Kay, M., Keenan, S. J., Kimberley, A. M., King, A., Laird, G. K., Langford, C., Lawlor, S., Leongamornlert, D. A., Leversha, M., Lloyd, C. R., Lloyd, D. M., Loveland, J. E., Lovell, J., Martin, S., Mashreghi-Mohammadi, M., Maslen, G. L., Matthews, L., McCann, O. T., McLaren, S. J., McLay, K., McMurray, A., Moore, M. J. F., Mullikin, J. C., Niblett, D., Nickerson, T., Novik, K. L., Oliver, K., Overton-Larty, E. K., Parker, A., Patel, R., Pearce, A. V., Peck, A. I., Phillimore, B., Phillips, S., Plumb, R. W., Porter, K. M., Ramsey, Y., Ranby, S. A., Rice, C. M., Ross, M. T., Searle, S. M., Sehra, H. K., Sheridan, E., Skuce, C. D., Smith, S., Smith, M., Spraggon, L., Squares, S. L., Steward, C. A., Sycamore, N., Tamlyn-Hall, G., Tester, J., Theaker, A. J., Thomas, D. W., Thorpe, A., Tracey, A., Tromans, A., Tubby, B., Wall, M., Wallis, J. M., West, A. P., White, S. S., Whitehead, S. L., Whittaker, H., Wild, A., Willey, D. J., Wilmer, T. E., Wood, J. M., Wray, P. W., Wyatt, J. C., Young, L., Younger, R. M., Bentley, D. R., Coulson, A., Durbin, R., Hubbard, T., Sulston, J. E., Dunham, I., Rogers, J., and Beck, S.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): A. J. Mungall (corresponding author) [1, 2]; S. A. Palmer [1]; S. K. Sims [1]; C. A. Edwards [1]; J. L. Ashurst [1]; L. Wilming [1]; M. C. Jones [...]

Published
2003
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42. Utilisation of paediatric surgical theatres at the Chris Hani Baragwanath Academic Hospital, Johannesburg.

Author

Ford, S., Brink, N., Martin, N., Soares, S., Manicom, B., Mahadea, T., Reynolds, M., Grieve, A., Loveland, J., and Gabler, T.

Subjects
PEDIATRICS, PUBLIC hospitals, ELECTIVE surgery, SURGERY, PEDIATRIC surgery, GOVERNMENT report writing
Abstract

Background. Optimal theatre utilisation is essential to reduce long waiting lists for elective surgeries and to increase cost-effective theatre operation. Utilisation rates well below the global benchmark of 80% have been reported for government hospitals in Johannesburg, South Africa (SA). Objective. To investigate utilisation of three paediatric theatres at the Chris Hani Baragwanath Academic Hospital (CHBAH) in Johannesburg. Methods. Surgery lists of the three theatres were reviewed for three one-week periods over a four-month study period. Preoperative, intraoperative and postoperative data were collected to create a timeline for each theatre and each surgical case, including reasons for cancellations, delays or expedited times. Results. A total of 152 surgeries were scheduled during the reviewed study period, of which 44 cases were cancelled. The utilisation rate was 59.8% across the three theatres combined, with individual rates calculated as 62.7%, 58.2% and 57.0% in the burns, general and neonatal theatres, respectively. The primary factor contributing to under-utilisation was early completion of the scheduled list. Surgery delays were mainly due to delays in transferring the patient to the theatre and between anaesthetic induction and the start of surgery. Conclusion. Utilisation of the paediatric theatres at CHBAH is below the ideal benchmark of 80%; however, utilisation was better than expected when compared with findings from other public-sector hospitals in SA. However, theatre efficiency was found to be very low and perhaps better explains the reasons for backlogs in paediatric surgeries at CHBAH. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Demographics of paediatric patients presenting with acute appendicitis: A 5-year retrospective review of hospitals served by the Department of Paediatric Surgery at the University of the Witwatersrand

Author

Withers, A and Loveland, J

Abstract

BACKGROUND. There are no recently published data on the incidence and demographics or perforation rates of paediatric patients from our local population presenting with acute appendicitis. OBJECTIVE. To show the age and gender distribution of paediatric patients presenting with acute appendicitis within our communities, as well as demonstrating the incidence of perforated acute appendicitis in our paediatric population. METHOD. The study is a retrospective record review of all paediatric patients who presented with acute appendicitis to the Department of Paediatric Surgery at both Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), and Chris Hani Baragwanath Academic Hospital (CHBAH) from June 2010 to September 2015. Data collected included all demographic data as well as histology results of patients who underwent appendectomies. RESULTS. The total numbers of patients included in the study were 544; 234 at CHBAH, and 311 at CMJAH. The male-to-female ratio was 1.58:1. The mean age for presentation at both hospitals combined was 8.76 years. We found that 13.41% of paediatric patients with acute appendicitis in this cohort were under the age of 6 years. A histological review showed that 50.1% of patients in our cohort presented with complicated appendicitis, and we had a negative appendectomy rate of 8.4%. Histological results of patients under the age of 6 years revealed a higher negative appendicectomy rate of 11.4%. However, the incidence of complicated appendicitis in this age group was only 45.7%, which is lower than that reported in the literature. Three patients were found to have Enterobius vermicularis in the lumen of the appendix, and Ascaris ova were identified in one patient. Histology revealed a low-grade mucinous neoplasm in one patient. CONCLUSION. Acute appendicitis occurred at a median age of 8.76 years in our study population, with a male-to-female ratio of 1.58:1. We found that acute appendicitis occurred relatively more frequently in our patients under the age of 6 years compared with the incidence of acute appendicitis in this age group published elsewhere. Complicated appendicitis occurred in 50.1% of our patient population, with an increased frequency of perforated appendicitis occurring in our male population. However, complicated appendicitis occurred in only 44.7% of our patients below the age of 6 years, which is in stark contrast to published literature. Helminthic infections were rare associated pathogens in our study, and an unlikely underlying pathogen of acute appendicitis in our population.

Published
2019

49. Living donor liver transplantation in South Africa: the donor experience

Author

Botha, J, primary, Ströbele, B, additional, Loveland, J, additional, Rambarran, S, additional, Britz, R, additional, Etheredge, H, additional, Maher, H, additional, Bolon, S, additional, Eagar, M, additional, Beeton, A, additional, Brannigan, L, additional, Mononyane, R, additional, Bannan, S, additional, Morford, M, additional, Smith, O, additional, and Fabian, J, additional

Published
2019
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