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1. V618 Sgr: Galactic eclipsing symbiotic nova detected in repeated outbursts

Author

Merc, J., Gális, R., Velez, P., Charbonnel, S., Garde, O., Dû, P. Le, Mulato, L., Petit, T., Bohlsen, T., Curry, S., Love, T., and Barker, H.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

V618 Sgr was previously classified as an R CrB-type variable and later as a possible symbiotic star. Our study aims to analyse the nature of this target, which is currently undergoing significant brightening in properties similar to those of known symbiotic novae. We analyse literature information, photometric observations, and 35 new optical spectra. Our findings strongly suggest that V618 Sgr is an eclipsing symbiotic nova currently in outburst. Additionally, since the star has demonstrated at least two similar brightenings in the past, we propose that V618 Sgr could be the first known galactic symbiotic nova observed in repeated outbursts of this type and may host a relatively massive white dwarf., Comment: 6 pages, 6 figures, 1 table; accepted in MNRAS

Published
2023
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11. MACHO Alert 95-30 : First Real-Time Observation of Extended Source Effects in Gravitational Microlensing

Author

Alcock, C., Allen, W. H., Allsman, R. A., Alves, D., Axelrod, T. S., Banks, T. S., Beaulieu, S. F., Becker, A. C., Becker, R. H., Bennett, D. P., Bond, I. A., Carter, B. S., Cook, K. H., Dodd, R. J., Freeman, K. C., Gregg, M., Griest, K., Hearnshaw, J. B., Heller, A., Honda, M., Jugaku, J., Kabe, S., Kaspi, S., Kilmartin, P. M., Kitamura, A., Kovo, O., Lehner, M. J., Love, T. E., Maoz, D., Marshall, S. L., Matsubara, Y., Minniti, D., Miyamoto, M., Muraki, Y., Nakamura, T., Peterson, B. A., Pratt, M. R., Quinn, P. J., Reid, I. N., Reid, M., Reiss, D., Retter, A., Rodgers, A. W., Sargent, W. L. W., Sato, H., Sekiguchi, M., Stetson, P. B., Stubbs, C. W., Sullivan, D. J., Sutherland, W., Tomaney, A., Vandehei, T., Watase, Y., Welch, D. L., Yanagisawa, T., Yoshizawa, M., and Yock, P. C. M.

Subjects
Astrophysics
Abstract

We present analysis of MACHO Alert 95-30, a dramatic gravitational microlensing event towards the Galactic bulge whose peak magnification departs significantly from the standard point-source microlensing model. Alert 95-30 was observed in real-time by the Global Microlensing Alert Network (GMAN), which obtained densely sampled photometric and spectroscopic data throughout the event. We interpret the light-curve ``fine structure'' as indicating transit of the lens across the extended face of the source star. This signifies resolution of a star several kpc distant. We find a lens angular impact parameter theta_{min}/theta_{source} = 0.715 +/- 0.003. This information, along with the radius and distance of the source, provides an additional constraint on the lensing system. Spectroscopic and photometric data indicate the source is an M4 III star of radius 61 +/- 12 Rsun, located on the far side of the bulge at 9 kpc. We derive a lens angular velocity, relative to the source, of 21.5 +/- 4.9 km/s/kpc, where the error is dominated by uncertainty in the source radius. Likelihood analysis yields a median lens mass of 0.67{+2.53}{-0.46} Msun, located with 80% probability in the Galactic bulge at a distance of 6.93{+1.56}{-2.25} kpc. If the lens is a main-sequence star, we can include constraints on the lens luminosity. This modifies our estimates to M_lens = 0.53{+0.52}{-0.35} Msun and D_lens = 6.57{+0.99}{-2.25} kpc. Spectra taken during the event show that the absorption line equivalent widths of H alpha and the TiO bands near 6700 A vary, as predicted for microlensing of an extended source. This is most likely due to center-to-limb variation in the stellar spectral lines. These data demonstrate the feasibility of using microlensing limb crossings as a tool to probe stellar atmospheres directly., Comment: 32 pages including 6 tables, and 15 figures; Uses AASTeX 4.0; submitted to The Astrophysical Journal

Published
1997
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12. Corticotropin‐releasing factor‐dopamine interactions in male and female macaque: Beyond the classic VTA.

Author

Kelly, E. A., Love, T. M., and Fudge, J. L.

Subjects
*MACAQUES, *CORTICOTROPIN releasing hormone, *TYROSINE hydroxylase, *ELECTRON microscopy, *FEMALES
Abstract

Dopamine (DA) is involved in stress and stress‐related illnesses, including many psychiatric disorders. Corticotropin‐releasing factor (CRF) plays a role in stress responses and targets the ventral midbrain DA system, which is composed of DA and non‐DA cells, and divided into specific subregions. Although CRF inputs to the midline A10 nuclei ("classic VTA") are known, in monkeys, CRF‐containing terminals are also highly enriched in the expanded A10 parabrachial pigmented nucleus (PBP) and in the A8 retrorubral field subregions. We characterized CRF‐labeled synaptic terminals on DA (tyrosine hydroxylase, TH+) and non‐DA (TH–) cell types in the PBP and A8 regions using immunoreactive electron microscopy (EM) in male and female macaques. CRF labeling was present mostly in axon terminals, which mainly contacted TH‐negative dendrites in both subregions. Most CRF‐positive terminals had symmetric profiles. In both PBP and A8, CRF symmetric (putative inhibitory) synapses onto TH‐negative dendrites were significantly greater than asymmetric (putative excitatory) profiles. This overall pattern was similar in males and females, despite shifts in the size of these effects between regions depending on sex. Because stress and gonadal hormone shifts can influence CRF expression, we also did hormonal assays over a 6‐month time period and found little variability in basal cortisol across similarly housed animals at the same age. Together our findings suggest that at baseline, CRF‐positive synaptic terminals in the primate PBP and A8 are poised to regulate DA indirectly through synaptic contacts onto non‐DA neurons. [ABSTRACT FROM AUTHOR]

Published
2024
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13. OP0022 COMPARATIVE EFFECTIVENESS OF BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN PSORIATIC ARTHRITIS ACCORDING TO COMORBIDITIES AT TREATMENT START: A NORDIC COLLABORATIVE STUDY BASED ON ENRICHED CLINICAL REGISTERS

Author

DI Giuseppe, D., primary, Lindström, U., additional, Wallman, J. K., additional, Delcoigne, B., additional, Bower, H., additional, Nordström, D., additional, Gudbjornsson, B., additional, Hetland, M. L., additional, Gröndal, G., additional, Sokka-Isler, T., additional, Aarrestad Provan, S., additional, Michelsen, B., additional, Kristianslund, E., additional, Dreyer, L., additional, Love, T., additional, Askling, J., additional, and Glintborg, B., additional

Published
2023
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14. OP0006 INTERSTITIAL LUNG DISEASE IN PATIENTS WITH RHEUMATOID OR PSORIATIC ARTHRITIS STARTING BDMARDS: INCIDENCE VS. GENERAL POPULATION, AND THE ROLE OF METHOTHREXATE CO-MEDICATION

Author

Aarrestad Provan, S., primary, Ljung, L., additional, Kristianslund, E., additional, Michelsen, B., additional, Uhlig, T., additional, Love, T., additional, Sexton, J., additional, Gudbjornsson, B., additional, DI Giuseppe, D., additional, Hetland, M. L., additional, Reynisdóttir, G. B., additional, Glintborg, B., additional, Relas, H., additional, Aaltonen, K., additional, Kvien, T. K., additional, and Askling, J., additional

Published
2023
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20. SEX DIFFERENCES IN EFFECTIVENESS OF FIRST-LINE TUMOR NECROSIS FACTOR INHIBITORS IN PSORIATIC ARTHRITIS; RESULTS FROM THIRTEEN COUNTRIES IN THE EUROSPA RESEARCH COLLABORATION NETWORK

Author

Pavelka, K., Hellamand, P., Trokovic, N., Sokka-Isler, T., Santos, M. J., Vieira-Sousa, E., Loft, A. G., Glintborg, B., Ostergaard, M., Lindstrom, U., Van der Horst-Bruinsmaon, I., Hetland, M. L., Sal, H. Yarkan-Tu, Kenar, G., Zavada, J., Love, T., Gudbjornsson, B., Pombo-Suarez, M., Castrejon, I., Tomsic, M., Fagerli, K. M., Wallman, J. K., Michelsen, B., Micheroli, R., Moeller, B., De Sande, M. G. H. Van, Codreanu, C., Ornbjerg, L. Midtboll, Mogosan, C., Laas, K., Klausch, T., and Rotar, Z.

Published
2022

21. Neural Correlates of Lexicon and Grammar: Evidence from the Production, Reading, and Judgment of Inflection in Aphasia

Author

Ullman, M.T, Pancheva, R., Love, T., Yee, E., Swinney, D., and Hickok, G.

Abstract

Are the linguistic forms that are memorized in the mental lexicon and those that are specified by the rules of grammar subserved by distinct neurocognitive systems or by a single computational system with relatively broad anatomic distribution? On a dual-system view, the productive -ed-suffixation of English regular past tense forms (e.g., look-looked) depends upon the mental grammar, whereas irregular forms (e.g., dig-dug) are retrieved from lexical memory. On a single-mechanism view, the computation of both past tense types depends on associative memory. Neurological double dissociations between regulars and irregulars strengthen the dual-system view. The computation of real and novel, regular and irregular past tense forms was investigated in 20 aphasic subjects. Aphasics with non-fluent agrammatic speech and left frontal lesions were consistently more impaired at the production, reading, and judgment of regular than irregular past tenses. Aphasics with fluent speech and word-finding difficulties, and with left temporal/temporo-parietal lesions, showed the opposite pattern. These patterns held even when measures of frequency, phonological complexity, articulatory difficulty, and other factors were held constant. The data support the view that the memorized words of the mental lexicon are subserved by a brain system involving left temporal/temporo-parietal structures, whereas aspects of the mental grammar, in particular the computation of regular morphological forms, are subserved by a distinct system involving left frontal structures.

Published
2005
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24. OP0257 RISK OF HAEMATOLOGICAL MALIGNANCY IN PATIENTS WITH PSORIATIC ARTHRITIS, OVERALL AND IN RELATION TO TNF INHIBITORS - A NORDIC COHORT STUDY

Author

Cordtz, R., primary, Askling, J., additional, Delcoigne, B., additional, Ekström Smedby, K., additional, Baecklund, E., additional, Ballegaard, C., additional, Isomäki, P., additional, Aaltonen, K., additional, Gudbjornsson, B., additional, Love, T., additional, Provan, S. A., additional, Michelsen, B., additional, Sexton, J., additional, Dreyer, L., additional, and Hellgren, K., additional

Published
2022
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25. POS0077 SEX DIFFERENCES IN EFFECTIVENESS OF FIRST-LINE TUMOR NECROSIS FACTOR INHIBITORS IN PSORIATIC ARTHRITIS; RESULTS FROM THIRTEEN COUNTRIES IN THE EuroSpA RESEARCH COLLABORATION NETWORK

Author

Hellamand, P., primary, Van de Sande, M. G. H., additional, Midtbøll Ørnbjerg, L., additional, Klausch, T., additional, Trokovic, N., additional, Sokka-Isler, T., additional, Santos, M. J., additional, Vieira-Sousa, E., additional, Loft, A. G., additional, Glintborg, B., additional, Østergaard, M., additional, Lindström, U., additional, Wallman, J. K., additional, Michelsen, B., additional, Moeller, B., additional, Micheroli, R., additional, Codreanu, C., additional, Mogosan, C., additional, Laas, K., additional, Rotar, Z., additional, Fagerli, K. M., additional, Tomsic, M., additional, Castrejon, I., additional, Pombo-Suarez, M., additional, Gudbjornsson, B., additional, Love, T., additional, Pavelka, K., additional, Zavada, J., additional, Kenar, G., additional, Yarkan-Tuğsal, H., additional, Hetland, M. L., additional, and Van der Horst-Bruinsma, I., additional

Published
2022
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27. SECULAR TRENDS IN BASELINE CHARACTERISTICS, TREATMENT RETENTION AND RESPONSE RATES IN 17453 BIONAIVE PSORIATIC ARTHRITIS PATIENTS INITIATING TNFI - RESULTS FROM THE EUROSPA COLLABORATION

Author

Van de Sande, M. G. H., Macfarlane, G., Ostergaard, M., Hetland, M. L., Sanchez-Piedra, C., Christiansen, S. N., Ornbjerg, L. Midtboll, Rasmussen, S. H., Loft, A. G., Wallman, J. K., Iannone, F., Michelsen, B., Nissen, M. J., Zavada, J., Santos, J., Pombo-Suarez, M., Eklund, K., Tomsic, M., Gudbjornsson, B., Sari, I., Codreanu, C., Di Giuseppe, D., Glintborg, B., Sebastiani, M., Fagerli, M., Moeller, B., Pavelka, K., Barcelos, A., Relas, H., Rotar, Z., Love, T., Akar, S., and Ionescu, R.

Published
2021

31. OP0220 SECULAR TRENDS IN BASELINE CHARACTERISTICS, TREATMENT RETENTION AND RESPONSE RATES IN 17453 BIONAÏVE PSORIATIC ARTHRITIS PATIENTS INITIATING TNFI – RESULTS FROM THE EUROSPA COLLABORATION

Author

Christiansen, S. N., primary, Midtbøll Ørnbjerg, L., additional, Rasmussen, S. H., additional, Loft, A. G., additional, Wallman, J. K., additional, Iannone, F., additional, Michelsen, B., additional, Nissen, M. J., additional, Zavada, J., additional, Santos, M. J., additional, Pombo-Suarez, M., additional, Eklund, K., additional, Tomsic, M., additional, Gudbjornsson, B., additional, Sari, İ., additional, Codreanu, C., additional, DI Giuseppe, D., additional, Glintborg, B., additional, Sebastiani, M., additional, Fagerli, K. M., additional, Moeller, B., additional, Pavelka, K., additional, Barcelos, A., additional, Sánchez-Piedra, C., additional, Relas, H., additional, Rotar, Z., additional, Love, T., additional, Akar, S., additional, Ionescu, R., additional, Macfarlane, G., additional, Van de Sande, M. G. H., additional, Hetland, M. L., additional, and Østergaard, M., additional

Published
2021
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32. Patient and stakeholder engagement learnings: PREP-IT as a case study

Author

Medeiros, Michelle, primary, Love, T Rosie, additional, Slobogean, Gerard P., additional, Sprague, Sheila, additional, Perfetto, Eleanor M., additional, O'Hara, Nathan N., additional, Mullins, C. Daniel, additional, Wells, Jeffrey, additional, Bhandari, Mohit, additional, D'alleyrand, Jean-Claude, additional, Harris, Anthony, additional, Mullins, Daniel C., additional, Thabane, Lehana, additional, Wood, Amber, additional, Della Rocca, Gregory J., additional, Hebden, Joan, additional, Jeray, Kyle J., additional, Marchand, Lucas, additional, O'Hara, Lyndsay M., additional, Zura, Robert, additional, Gardner, Michael J., additional, Blasman, Jenna, additional, Davies, Jonah, additional, Liang, Stephen, additional, Taljaard, Monica, additional, Devereaux, PJ, additional, Guyatt, Gordon H., additional, Heels-Ansdell, Dianne, additional, Marvel, Debra, additional, Palmer, Jana, additional, Friedrich, Jeff, additional, O'Hara, Nathan, additional, Grissom, Frances, additional, Gitajn, Leah, additional, Morshed, Saam, additional, O'Toole, Robert, additional, Petrisor, Bradley A., additional, Camara, Megan, additional, Mossuto, Franca, additional, Joshi, Manjari G., additional, Fowler, Justin, additional, Rivera, Jessica, additional, Talbot, Max, additional, Dodds, Shannon, additional, Garibaldi, Alisha, additional, Li, Silvia, additional, Nguyen, Uyen, additional, Pogorzelski, David, additional, Rojas, Alejandra, additional, Scott, Taryn, additional, Del Fabbro, Gina, additional, Szasz, Olivia Page, additional, McKay, Paula, additional, Howe, Andrea, additional, Rudnicki, Joshua, additional, Demyanovich, Haley, additional, Little, Kelly, additional, Boissonneault, Adam, additional, Medeiros, Michellic, additional, Kettering, Eric, additional, Hale, Diamond, additional, Mahal, Nirmen, additional, Eglseder, Andrew, additional, Johnson, Aaron, additional, Langhammer, Christopher, additional, Lebrun, Christopher, additional, Manson, Theodore, additional, Nascone, Jason, additional, Paryavi, Ebrahim, additional, Pensy, Raymond, additional, Pollack, Andrew, additional, Sciadini, Marcus, additional, Degani, Yasmin, additional, Joseph, Katherine, additional, S. Marchand, Lucas, additional, Phipps, Heather, additional, Hempen, Eric, additional, Johal, Herman, additional, Risteyski, Bill, additional, Williams, Dale, additional, Denkers, Matthew, additional, Rajaratnam, Krishan, additional, Al-Asiri, Jamal, additional, Leonard, Jordan, additional, Marcano-Fernández, Francesc A., additional, Gallant, Jodi, additional, Persico, Federico, additional, Gjorgjievski, Marko, additional, George, Annie, additional, McGaugh, Sarah M., additional, Pusztai, Kaitlyn, additional, Piekarski, Sarah, additional, Lyons, Mavis, additional, Gennaccaro, Julia, additional, Natoli, Roman M., additional, Gaski, Greg E., additional, McKinley, Todd O., additional, Virkus, Walter W., additional, Sorkin, Anthony T., additional, Szatkowski, Jan P., additional, Baele, Joseph R., additional, Mullis, Brian H., additional, Jang, Yohan, additional, Lopas, Luke A., additional, Hill, Lauren C., additional, Hudgins, Andrea, additional, Fentz, Courteney L., additional, Diaz, Maricela M., additional, Garst, Katelyn M., additional, Denari, Emma W., additional, Osborn, Patrick, additional, Pierrie, Sarah, additional, Martinez, Eric, additional, Kimmel, Joseph, additional, Herrera, Maria, additional, Adams, John D., additional, Beckish, Michael, additional, Bray, Christopher, additional, Brown, Timothy R., additional, Cross, Andrew W., additional, Dew, Timothy, additional, Faucher, Gregory, additional, Gurich Jr, Richard W., additional, Lazarus, David E., additional, Millon, S. John, additional, Palmer, M. Jason, additional, Porter, Scott E., additional, Schaller, Thomas M., additional, Sridhar, Michael S., additional, Sanders, John L., additional, Rudisill Jr, Edwin L., additional, Garitty, Michael J., additional, Poole, Andrew S., additional, Sims, Michael L., additional, Walker, Clark M., additional, Carlisle II, Robert M., additional, Hofer, Erin Adams, additional, Huggins, Brandon S., additional, Hunter, Michael D., additional, Marshall, William A., additional, Ray, Shea Bielby, additional, Smith, Cory D., additional, Altman, Kyle M., additional, Bedard, Julia C., additional, Loeffler, Markus F., additional, Pichiotino, Erin R., additional, Cole, Austin A., additional, Maltz, Ethan J., additional, Parker, Wesley, additional, Ramsey, T. Bennett, additional, Burnikel, Alex, additional, Colello, Michael, additional, Stewart, Russell, additional, Wise, Jeremy, additional, Moody, M. Christian, additional, Anderson, Matthew, additional, Eskew, Joshua, additional, Judkins, Benjamin, additional, Miller, James M., additional, Tanner, Stephanie L., additional, Snider, Rebecca G., additional, Townsend, Christine E., additional, Pham, Kayla H., additional, Martin, Abigail, additional, Robertson, Emily, additional, Wilson Sykes, John, additional, Miclau, Theodore, additional, Kandemir, Utku, additional, Marmor, Meir, additional, Matityahu, Amir, additional, McClellan, R. Trigg, additional, Meinberg, Eric, additional, Shearer, David, additional, Toogood, Paul, additional, Ding, Anthony, additional, Donohue, Erin, additional, Murali, Jothi, additional, El Naga, Ashraf, additional, Tangtiphaiboontana, Jennifer, additional, Belaye, Tigist, additional, Berhaneselase, Eleni, additional, Paul, Alexandra, additional, Garg, Kartik, additional, Pokhvashchev, Dmitry, additional, Gary, Joshua L., additional, Warner, Stephen J., additional, Munz, John W., additional, Choo, Andrew M., additional, Achor, Timothy, additional, Routt, Milton L. "Chip", additional, Rao, Mayank, additional, Pechero, Guillermo, additional, Miller, Adam, additional, Kutzler, Michael, additional, Boutte, Sterling, additional, Warth, Ryan J., additional, Hagen, Jennifer E., additional, Patrick, Matthew, additional, Vlasak, Richard, additional, Krupko, Thomas, additional, Sadasivan, Kalia, additional, Talerico, Michael, additional, Horodyski, Marybeth, additional, Koenig, Chris, additional, Bailey, Daniel, additional, Wentworth, Daniel, additional, Van, Chi, additional, Schwartz, Justin, additional, Pazik, Marissa, additional, Lossada-Soto, Elizabeth, additional, Dehghan, Niloofar, additional, Jones, Clifford B., additional, Watson, J. Tracy, additional, McKee, Michael, additional, Karim, Ammar, additional, Sietsema, Debra L., additional, William, Alyse, additional, Dykes, Tayler, additional, Obremskey, William T., additional, Jahangir, Amir Alex, additional, Sethi, Manish, additional, Boyce, Robert, additional, Stinner, Daniel J., additional, Mitchell, Phillip, additional, Trochez, Karen, additional, Rodriguez, Andres, additional, Gajari, Vamshi, additional, Rodriguez, Elsa, additional, Pritchett, Chris, additional, Hogan, Natalie, additional, Moreno, Fidel A., additional, Boulton, Christina, additional, Lowe, Jason, additional, Wild, Jason, additional, Ruth, John T., additional, Taylor, Michel, additional, Askam, Brad, additional, Seach, Andrea, additional, Saeed, Sabina, additional, Culbert, Hunter, additional, Crus, Alejandro, additional, Knapp, Thomas, additional, Hurkett, Colin, additional, Lowney, Maya, additional, Featherston, Breanna, additional, Carlson, Robin, additional, Romero, Iliana, additional, Zarif, Isaac, additional, Prayson, Michael, additional, Venkatarayappa, Indresh, additional, Horne, Brandon, additional, Jerele, Jennifer, additional, Clark, Linda, additional, Marcano-Fernández, Francesc, additional, Jornet-Gibert, Montsant, additional, Martínez-Carreres, Laia, additional, Martí-Garín, David, additional, Serrano-Sanz, Jorge, additional, Sánchez-Fernández, Joel, additional, Sanz-Molero, Matsuyama, additional, Carballo, Alejandro, additional, Pelfort, Xavier, additional, Acerboni-Flores, Francesc, additional, Alavedra-Massana, Anna, additional, Anglada-Torres, Neus, additional, Berenguer, Alexandre, additional, Cámara-Cabrera, Jaume, additional, Caparros-García, Ariadna, additional, Fillat-Gomà, Ferran, additional, Fuentes-López, Ruben, additional, Garcia-Rodriguez, Ramona, additional, Gimeno-Clavia, Nuria, additional, Graells-Alonso, Guillem, additional, Martínez-álvarez, Marta, additional, Martínez-Grau, Patricia, additional, Pellejero-García, Raúl, additional, Ràfols-Perramon, Ona, additional, Peñalver, Juan Manuel, additional, Salomò Domènech, Mònica, additional, Soler-Cano, Albert, additional, Velasco-Barrera, Aldo, additional, Yela-Verdú, Christian, additional, Bueno-Ruiz, Mercedes, additional, Sánchez-Palomino, Estrella, additional, Andriola, Vito, additional, Molina-Corbacho, Matilde, additional, Maldonado-Sotoca, Yeray, additional, Gasset-Teixidor, Alfons, additional, Blasco-Moreu, Jorge, additional, Fernández-Poch, Núria, additional, Rodoreda-Puigdemasa, Josep, additional, Verdaguer-Figuerola, Arnau, additional, Enrique Cueva-Sevieri, Heber, additional, Garcia-Gimenez, Santiago, additional, Guerra-Farfán, Ernesto, additional, Tomas-Hernandez, Jordi, additional, Teixidor-Serra, Jordi, additional, Molero-Garcia, Vicente, additional, Selga-Marsa, Jordi, additional, Porcel-Vazquez, Juan Antonio, additional, Andres-Peiro, Jose Vicente, additional, Minguell-Monyart, Joan, additional, Nuñez-Camarena, Jorge, additional, del Mar Villar-Casares, Maria, additional, Mestre-Torres, Jaume, additional, Lalueza-Broto, Pilar, additional, Moreira-Borim, Felipe, additional, García, Yaiza, additional, Romeo, Nicholas M., additional, Vallier, Heather A., additional, Breslin, Mary A., additional, Fraifogl, Joanne, additional, Wilson, Eleanor S., additional, Wadenpfuhl, Leanne K, additional, Halliday, Paul G., additional, Heimke, Isabella, additional, Viskontas, Darius G., additional, Apostle, Kelly L., additional, Boyer, Dory S., additional, Moola, Farhad O., additional, Perey, Bertrand H., additional, Stone, Trevor B., additional, Lemke, H. Michael, additional, Zomar, Mauri, additional, Spicer, Ella, additional, Fan, Chen "Brenda", additional, Payne, Kyrsten, additional, Phelps, Kevin, additional, Bosse, Michael, additional, Karunakar, Madhav, additional, Kempton, Laurence, additional, Sims, Stephen, additional, Hsu, Joseph, additional, Seymour, Rachel, additional, Churchill, Christine, additional, Bartel, Claire, additional, Mayberry, Robert Miles, additional, Brownrigg, Maggie, additional, Girardi, Cara, additional, Mayfield, Ada, additional, Sweeney, Juliette, additional, Pollock, Hannah, additional, Hymes, Robert A., additional, Schwartzbach, Cary C., additional, Schulman, Jeff E., additional, Malekzadeh, A. Stephen, additional, Holzman, Michael A., additional, Wills, Jonathan, additional, Ramsey, Lolita, additional, Ahn, James S., additional, Panjshiri, Farhanaz, additional, Das, Sharmistha, additional, English, Antoinisha D., additional, Haaser, Sharon M., additional, Cuff, Jaslynn A.N., additional, Pilson, Holly, additional, Carroll, Eben A., additional, Halvorson, Jason J., additional, Babcock, Sharon, additional, Goodman, J. Brett, additional, Holden, Martha B., additional, Bullard, Debra, additional, Williams, Wendy, additional, Hill, Taylor, additional, Brotherton, Ariel, additional, Higgins, Thomas F., additional, Haller, Justin M., additional, Rothberg, David L., additional, Neese, Ashley, additional, Russell, Mark, additional, Olsen, Zachary M., additional, McGowan, Abby V., additional, Hill, Sophia, additional, Coe, Marcus, additional, Dwyer, Kevin, additional, Mullin, Devin S., additional, Reily, Clifford A, additional, DePalo, Peter, additional, Hall, Amy E., additional, Dabrowski, Rebecca E., additional, Chockbengboun, Theresa A., additional, Heng, Marilyn, additional, Harris, Mitchel B., additional, Smith, R. Malcolm, additional, Lhowe, David W., additional, Esposito, John, additional, Bansal, Mira, additional, McTague, Michael, additional, Alnasser, Ahmad, additional, Bergin, Patrick F., additional, Russell, George V., additional, Graves, Matthew L., additional, Morellato, John, additional, Champion, Heather K., additional, Johnson, Leslie N., additional, McGee, Skeketha L., additional, Bhanat, Eldrin L., additional, Thimothee, Josny, additional, Serrano, Jackie, additional, Mehta, Samir, additional, Donegan, Derek, additional, Ahn, Jaimo, additional, Horan, Annamarie, additional, Dooley, Mary, additional, Kuczinski, Ashley, additional, Iwu, Ashley, additional, Potter, David, additional, VanDemark II, Robert, additional, Pfaff, Branden, additional, Hollinsworth, Troy, additional, Atkins, Kristi, additional, Weaver, Michael J., additional, von Keudel, Arvind G., additional, McTague, Michael F., additional, Allen, Elizabeth M., additional, Sagona, Abigail E., additional, Jaeblon, Todd, additional, Beer, Robert, additional, Bauer, Brent, additional, Meredith, Sean, additional, Stone, Autumn, additional, Gage, Mark J., additional, Reilly, Rachel M., additional, Sparrow, Cindy, additional, Paniagua, Ariana, additional, Domes, Christopher M., additional, Johnson, Kristina P., additional, Shannon, Steven F., additional, Scott, Alesha N., additional, Clinch, Bobbi, additional, Lin, Carol A., additional, Vrahas, Mark S., additional, Moon, Charles N., additional, Marecek, Geoffrey S., additional, Dubuclet, Denice, additional, Scolaro, John A., additional, Learned, James R., additional, Lim, Philip K., additional, Demas, Susan, additional, Beltran, Michael J., additional, Archdeacon, Michael T., additional, Claude Sagi, Henry, additional, Wyrick, John D., additional, Toan Le, Theodore, additional, Laughlin, Richard T., additional, and Thomson, Cameron G., additional

Published
2021
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38. Engagement in Integrative and Nonpharmacologic Pain Management Modalities Among Adults with Chronic Pain: Analysis of the 2019 National Health Interview Survey

Author

Rodgers-Melnick SN, Trager RJ, Love TE, and Dusek JA

Subjects
integrative medicine, chronic pain, nonpharmacologic, opioids, Medicine (General), R5-920
Abstract

Samuel N Rodgers-Melnick,1,2 Robert J Trager,1 Thomas E Love,2– 4 Jeffery A Dusek5 1Connor Whole Health, University Hospitals of Cleveland, Cleveland, OH, USA; 2Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 3Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 4Population Health and Equity Research Institute, The MetroHealth System, Cleveland, OH, USA; 5Department of Family Medicine and Community Health, Case Western Reserve University School of Medicine, Cleveland, OH, USACorrespondence: Samuel N Rodgers-Melnick, University Hospitals Connor Whole Health, 11100 Euclid Avenue, Wearn 548A, Cleveland, OH, 44106, USA, Tel +1 216 844 7727, Fax +1 216 201 6220, Email Samuel.RodgersMelnick@UHhospitals.orgObjective: To examine variables associated with engagement in (1) integrative health and medicine (IHM) and (2) nonpharmacologic modalities rather than opioids among United States adults with chronic pain.Methods: Using the 2019 National Health Interview Survey, we examined sociodemographic, pain, and mental health predictors of (1) the sum of IHM modalities (ie, chiropractic care, yoga/Tai Chi, massage, or meditation/guided imagery) used to manage pain and (2) exclusive engagement in nonpharmacologic pain management modalities (ie, IHM, a chronic pain self-management program, support groups, or physical, rehabilitative, occupational, or talk therapy) or opioids in the past 3 months.Results: Metropolitan residency, higher family income, higher education levels, increased number of pain locations, and increased frequency of pain limiting life/work activities were associated with increased odds of IHM engagement. Older age, male sex, non-Hispanic Black/African American race/ethnicity, and daily opioid use were associated with decreased odds of IHM engagement. Older age, male sex, and increased depressive symptoms were associated with decreases in the count of IHM modalities used to manage pain. Metropolitan residency, higher family income, and higher education levels were associated with increased odds of exclusive nonpharmacologic modality engagement. Older age and increasing frequency of pain limiting life/work activities were associated with decreased odds of exclusive nonpharmacologic modality engagement.Conclusions: We identified several contrasts between factors prevalent among individuals with chronic pain and factors associated with engagement in nonpharmacologic and IHM modalities. These results support efforts to address barriers to accessing these modalities among subpopulations of adults with chronic pain (eg, older adults, individuals identifying as Black/African American, rural residents, and those with lower levels of education and income).Plain Language Summary: This study examined factors influencing the use of integrative health and non-drug treatments for chronic pain in the United States. Results revealed that metropolitan residence, higher income, and education were associated with increased use of these treatments, while older age, male sex, daily opioid use, and non-Hispanic Black/African American ethnicity were associated with decreased use. The findings emphasize the importance of addressing barriers to these forms of care, especially among older adults, Black/African American individuals, and those with higher depressive symptoms and lower education and income levels, who are more likely to have chronic pain.Keywords: integrative medicine, chronic pain, nonpharmacologic, opioids

Published
2024

39. SAT0430 SECUKINUMAB EFFECTIVENESS IN 1543 PATIENTS WITH PSORIATIC ARTHRITIS TREATED IN ROUTINE CLINICAL PRACTICE IN 13 EUROPEAN COUNTRIES IN THE EuroSpA RESEARCH COLLABORATION NETWORK

Author

Michelsen, B., primary, Georgiadis, S., additional, DI Giuseppe, D., additional, Loft, A. G., additional, Nissen, M., additional, Iannone, F., additional, Pombo-Suarez, M., additional, Mann, H., additional, Rotar, Z., additional, Eklund, K., additional, Kvien, T. K., additional, Santos, M. J., additional, Gudbjornsson, B., additional, Codreanu, C., additional, Yilmaz, S., additional, Wallman, J. K., additional, Brahe, C. H., additional, Moeller, B., additional, Favalli, E. G., additional, Sánchez-Piedra, C., additional, Nekvindova, L., additional, Tomsic, M., additional, Trokovic, N., additional, Kristianslund, E., additional, Santos, H., additional, Love, T., additional, Ionescu, R., additional, Pehlivan, Y., additional, Jones, G. T., additional, Van der Horst-Bruinsma, I., additional, Midtbøll Ørnbjerg, L., additional, Ǿstergaard, M., additional, and Hetland, M. L., additional

Published
2020
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42. THU0394 COMPARISON OF TREATMENT RETENTION OF SECUKINUMAB AND TNF-INHIBITORS IN PSORIATIC ARTHRITIS. OBSERVATIONAL DATA FROM A NORDIC COLLABORATION.

Author

Lindström, U., primary, Glintborg, B., additional, DI Giuseppe, D., additional, Schjødt Jørgensen, T., additional, Gudbjornsson, B., additional, Grøn, K. L., additional, Aarrestad Provan, S., additional, Michelsen, B., additional, Hetland, M. L., additional, Wallman, J. K., additional, Nordström, D., additional, Trokovic, N., additional, Love, T., additional, Steen Krogh, N., additional, Askling, J., additional, Jacobsson, L. T. H., additional, and Kristensen, L. E., additional

Published
2020
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44. FRI0283 CO-MEDICATION WITH CSDMARD HAS LITTLE EFFECT ON THE RETENTION OF TNF INHIBITORS IN PSORIATIC ARTHRITIS, RESULTS FROM THE EUROSPA COLLABORATION

Author

Lindström, U., primary, DI Giuseppe, D., additional, Delcoigne, B., additional, Glintborg, B., additional, Moeller, B., additional, Pombo-Suarez, M., additional, Sánchez-Piedra, C., additional, Eklund, K., additional, Relas, H., additional, Gudbjornsson, B., additional, Love, T., additional, Jones, G. T., additional, Ciurea, A., additional, Codreanu, C., additional, Ionescu, R., additional, Nekvindova, L., additional, Zavada, J., additional, Atas, N., additional, Yolbaş, S., additional, Fagerli, K., additional, Michelsen, B., additional, Rotar, Z., additional, Tomsic, M., additional, Iannone, F., additional, Santos, M. J., additional, Ávila-Ribeiro, P., additional, Midtbøll Ørnbjerg, L., additional, Ǿstergaard, M., additional, Jacobsson, L. T. H., additional, Askling, J., additional, and Nissen, M., additional

Published
2020
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47. Importance of indigenous communities’ knowledge and perception in achieving biodiversity conservation: A case study from Manobo tribe of Southern Mindanao, Philippines

Author

Shane Love T. Arnibal and Florence Roy P. Salvaña

Subjects
Pulmonary and Respiratory Medicine, media_common.quotation_subject, Significant difference, Biodiversity, Indigenous, Biodiversity conservation, Geography, Local government, Perception, Tribe, Pediatrics, Perinatology, and Child Health, Traditional knowledge, Socioeconomics, media_common
Abstract

Salvaña FRP, Arnibal SLT. 2019. Importance of indigenous communities’ knowledge and perception in achieving biodiversity conservation: A case study from Manobo tribe of Southern Mindanao, Philippines. Asian J Ethnobiol 2: 54-61. Indigenous communities play a relevant role for setting biodiversity management and conservation. This study aims to determine the knowledge and perceived importance of the Manobo tribe towards biodiversity. A total of 100 Manobos were included in the study to determine the knowledge and perception of indigenous communities particularly the Manobo tribe towards biodiversity. A semi-structured survey questionnaire was used to determine responses on knowledge and importance perception/ Our study found a consistent significant difference on the mean responses on knowledge and perception across gender and education attainment. Interestingly, traditional knowledge is significantly associated on the biodiversity importance perception of Manobos. Our findings suggest involving indigenous communities is equally important in achieving balanced biodiversity conservation and protection. Thus, strengthening collaborations among local government sectors and community leaders must be included in developing conservation priorities and protection.

Published
2020
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48. Some dynamical aspects of generic disordered systems

Author

Lezama Mergold Love, T., Bardarson, Jens H., Luitz, David J., Moessner, Roderich, Votja, Matthias, Technische Universität Dresden, and Max-Planck-Institut für Physik komplexer Systeme

Subjects
Stochastic processes, ddc:530, many-body localization, nonequilibrium quantum dynamics, entanglement
Abstract

In this thesis, we focus attention on the effects of disorder in closed interacting quantum systems that give rise to a many-body localization (MBL) transition between an ergodic phase and a many-body localized phase. This transition is not a conventional one, since it takes place at any finite energy density and can neither be described by thermodynamics nor conventional statistical mechanics. We explain why systems experiencing such an MBL transition can be regarded as generic in many ways, we do so by discussing many of their spectral properties and by giving a detailed account of their manifestation in the nonequilibrium dynamics and long-time behavior. Surprisingly, a wide variety of MBL systems consistently reflect strikingly similar characteristic effects in each side of the MBL transition. This is backed by myriads of numerical and experimental observations which in turn can be partially explained by theories developed in the past decade. However, some mechanisms behind the ergodic side of the MBL transition and the nature of the MBL transition itself remain elusive. These, as well as the lack of an accurate description of the nonergodic character of the steady states of such systems, have been some of the issues for active research and speculation by scholars that need to be timely addressed. In the following, we describe our modest contributions at bridging the gap of understanding of some of the issues exposed above. On the one hand, reduced density matrices are central objects for the description of the relaxation of local observables in closed quantum many-body systems, and on the other, quench protocols are experimentally relevant procedures. In the first part of this thesis we study the long-time behavior of the one-particle density matrix (OPDM) occupation spectrum after a quench. It was shown that, in the many-body localized phase (which can be understood in terms of localized quasiparticles), the OPDM occupation spectrum in eigenstates shows a zero-temperature Fermi liquid-like discontinuity at any finite energy density. In this thesis we show that in the steady state reached at long times after a global quench from a perfect density-wave state, the discontinuity in the OPDM occupation spectrum is absent, reminiscent of a Fermi liquid at a finite temperature, while the full occupation function remains strongly nonthermal. We discuss how one can understand this as a consequence of the local structure of the density-wave state and the resulting partial occupation of quasiparticles. We further show how these partial occupations can be controlled by tuning the structure of initial state and described by an effective temperature. Another part of this thesis was devoted to the study of dynamics on the ergodic side of the transition in periodically driven systems in the absence of global conservation laws. Most numerical studies in this context were done in models with conserved quantities (e.g., energy and/or particle number) which could account for the reduction of the overall complexity of the problem, while in this thesis, we use a numerical technique based on the fast Walsh-Hadamard transform that allows us to perform an exact time evolution for large systems and long times. As in models with conserved quantities, we observe a slowing down of the dynamics as the transition into the many-body localized phase is approached. This is reflected in anomalous behavior of the energy absorption of the system, as well as consistent with a subballistic spread of entanglement and a stretched-exponential decay of an autocorrelation function, with their associated exponents reflecting slow dynamics near the transition for a fixed system size. However, with access to larger system sizes, we observe a clear flow of the exponents towards faster dynamics and cannot rule out that the slow dynamics is a finite-size effect. Furthermore, we observe examples of nonmonotonic dependence of the exponents with time, with the dynamics initially slowing down but accelerating again at larger times, which could be consistent with the slow dynamics being a crossover phenomenon with a localized critical point. In addition, we observe no difference between the typical and average value of the autocorrelation function and therefore our results are inconsistent with the phenomenological explanation of the anomalous behavior based on Griffiths effects. In the last part of this thesis, we study dynamics in the ergodic phase relating to two main quantum information measures: One is the entanglement entropy, which is an intrinsic property of the wave function and generated by the time evolution operator, while the other is the operator entanglement entropy of the time evolution operator, which quantifies the complexity of the latter. It is known that generic quantum many-body systems typically show a linear growth of the entanglement entropy growth after a quench from a product state. In this thesis we show that there is a robust correspondence between the operator entanglement entropy of the time evolution operator and the entanglement entropy growth of typical product states, whereas special product states, e.g., $\sigma_z$ basis states, may exhibit faster entanglement production. We base our analysis on numerical simulations of a static and a periodically driven quantum spin chain in the presence of a disordered magnetic field, showing that both the wave function and operator entanglement entropies exhibit a power-law growth with the same disorder-dependent exponent. With this, we clarify the discrepancy between the exponents observed in previous results. Our results provide further evidence for slow information spreading on the ergodic side of the many-body localization transition in the absence of conservation laws. In dieser Dissertation setzen wir uns mit dem Effekt von Unordnung auf geschlossene wechselwirkende Quantensysteme auseinander. Unordnung kann einen Übergang von einer ergodischen in eine lokalisierte Phase induzieren, eine sogenannte Vielteilchenlokalisierung oder Many body localization (MBL). Dieser Phasenübergang ist alles andere als konventionell: Er kann weder durch Thermodynamik noch durch klassische statistische Mechanik beschrieben werden. Wir erklären, warum Systeme, die solch einen MBL Übergang aufweisen, in vielerlei Hinsicht als generisch angesehen werden können. Dazu diskutieren wir die spektralen Eigenschaften, die Nichtgleichgewichtsdynamik und das Langzeitverhalten. Erstaunlicherweise weist eine große Vielfalt verschiedener MBL Systeme auf beiden Seiten des MBL Übergangs mit großer Konsistenz ähnliche Charakteristiken auf. Dies wird durch unzählige numerische und experimentelle Beobachtungen unterstützt, die wiederum zumindest teilweise durch theoretische Arbeiten aus dem letzten Jahrzehnt erklärt werden können. Trotzdem bleiben manche Mechanismen auf der ergodischen Seite des MBL Übergangs und die Art des MBL Übergangs weiterhin im Verborgenen. Zusammen mit der fehlenden akkuraten Beschreibung des nicht-ergodischen Charakters der stationären Zustände dieser Systeme sind diese Probleme im derzeitigen Fokus der Forschung, wobei es eine Vielzahl fundierter Vermutungen gibt, die diese Phänomene erklären. Im Folgenden beschreiben wir unseren Beitrag wie diese oben gelisteten Probleme überwunden werden können. Reduzierte Dichteoperatoren sind zentrale Objekte, um die Relaxation von lokalen Observablen in geschlossenen Quantenvielkörpersystemen zu beschreiben und sogenannte Quenches, also die plötzliche Änderung einiger systemrelevanter Parameter, ähnlich wie beim Abschrecken mit Wasser oder Luft, sind experimentell relevante Vorgänge. Im ersten Teil dieser Arbeit untersuchen wir das Langzeitverhalten des Besetzungsspektrums des Einteilchendichteoperators (one-particle density matrix, OPDM) nach solch einem Quench. Wie zuvor gezeigt wurde, weist das OPDM Besetzungsspektrum in der MBL Phase (die im Sinne von lokalisierten Quasiteilchen verstanden werden kann) für alle endlichen Energiedichten eine Diskontinuität auf, ähnlich wie in Fermi-Flüssigkeiten. In dieser Arbeit zeigen wir, dass diese Diskontinuität in stationären Zuständen, die von perfekten Dichtewellen ausgehend nach langer Zeit nach einem globalen Quench erreicht werden, abwesend ist, ähnlich wie in einer Fermi-Flüssigkeit bei einer endlichen Temperatur, während die gesamte Besetzungsfunktion stark nicht-thermal bleibt. Wir diskutieren, wie man dies als Konsequenz der lokalen Struktur des Dichtewellenzustands und der daraus folgenden teilweisen Besetzung der Quasiteilchen verstehen kann. Wir zeigen außerdem, wie die teilweise Besetzung durch Änderung der Struktur des Ausgangszustands kontrolliert und durch eine effektive Temperatur beschrieben werden kann. Im nächsten Teil dieser Arbeit untersuchen wir die Dynamik der ergodischen Seite des MBL Übergangs in periodisch getriebenen Systemen ohne globale Erhaltungsgrößen. Die meisten bisherigen in diesem Zusammenhang vorgenommenen numerischen Untersuchungen wurden in Modellen mit Erhaltungsgrößen (wie Energie und/oder Teilchenzahl) durchgeführt, was an der Reduzierung der Komplexität des Problems liegen mag. In dieser Arbeit nutzen wir hingegen eine numerische Methode, die auf einer schnellen Walsh-Hadamard Transformation beruht, was uns ermöglicht, eine exakte Zeitentwicklung für lange Zeiten und große Systeme vorzunehmen. Wie in Modellen mit Erhaltungsgrößen beobachten wir eine Verlangsamung der Dynamik, wenn wir uns dem Übergangspunkt zu der MBL Phase nähern. Dies macht sich in einem ungewöhnlichen Verhalten der Energieabsorption des Systems bemerkbar, was mit einer unterballistischen Ausbreitung der Verschränkung und einem gedehnt-exponentiellen Abklingen der Autokorrelationsfunktion im Einklang steht, wobei die zugehörigen Exponenten die verlangsamte Dynamik für fixe Systemgrößen widerspiegeln. Durch den Zugang zu größeren Systemen können wir jedoch einen deutlichen Fluss der Exponenten Richtung schnellerer Dynamik feststellen und daher nicht ausschließen, dass die verlangsamte Dynamik durch die endlichen Systemgrößen hervorgerufen wird (ein sogenannter finite size effect). Des weiteren finden wir Beispiele für eine nicht-monotone Zeitabhängigkeit der Exponenten, wobei die Dynamik sich zunächst verlangsamt, bevor sie zu späteren Zeiten wieder beschleunigt. Dies könnte mit der Betrachtung der verlangsamten Dynamik als Crossover-Phänomen mit einem lokalisierten kritischen Punkt vereinbar sein. Außerdem können wir keinen Unterschied zwischen dem geometrischen und arithmetischen Mittel der Autokorrelationsfunktion feststellen, sodass unsere Ergebnisse der phänomenologischen Erklärung des ungewöhnlichen Verhaltens, die auf Griffiths-Effekten beruht, widersprechen. Im letzten Teil der Dissertation widmen wir der Dynamik in der ergodischen Phase und verknüpfen zwei zentrale Größen der Quanteninformation: die Verschränkungsentropie, eine der Wellenfunktion intrinsische Größe, die aus dem Zeitentwicklungsoperator generiert werden kann, und der Operatorverschränkungsentropie des Zeitentwicklungsoperators, die die Komplexität des Operators quantifiziert. In generischen Quantenvielkörpersystemen wächst die Verschränkungsentropie nach einem Quench aus einem Produktzustand typischerweise linear. In dieser Arbeit zeigen wir, dass es eine belastbaren Übereinstimmung zwischen der Operatorverschränkungsentropie des Zeitentwicklungsoperators und der Verschränkungsentropie typischer Produktzustände gibt, wobei bestimmte Produktzustände, z.B. $\sigma_z$-Basiszustände, eine schnellere Verschränkungsproduktion aufweisen können. Unsere Analyse basiert auf numerischen Simulationen von statischen und periodisch getriebenen Quanten-Spinketten in einem ungeordneten Magnetfeld. Sowohl die Verschränkungsentropie der Wellenfunktion als auch die Operatorverschränkungsentropie wächst einem Potenzgesetz folgend mit den selben unordnungsabhängigen Exponenten. Damit schaffen wir Klarheit bezüglich der Unstimmigkeiten der Exponenten in den vorherigen Ergebnissen. Unsere Resultate geben außerdem Hinweise auf eine verlangsamte Informationsausbreitung auf der ergodischen Seite des MBL Übergangs ohne Erhaltungsgrößen.

Published
2019

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