1. Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions
- Author
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Alison E, Brown, Robert J, Gifford, Jonathan P, Clewley, Claudia, Kucherer, Bernard, Masquelier, Kholoud, Porter, Claudia, Balotta, Nicole K T, Back, Louise Bruun, Jorgensen, Carmen, de Mendoza, Krishnan, Bhaskaran, O Noel, Gill, Anne M, Johnson, Deenan, Pillay, Harold, Jaffe, Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Infectious diseases, and Epidemiology and Data Science
- Subjects
Acute HIV infection ,Infectivity ,Male ,medicine.medical_specialty ,Phylogenetic tree ,Transmission (medicine) ,Human immunodeficiency virus (HIV) ,Genetic Variation ,HIV Infections ,Biology ,medicine.disease_cause ,Virology ,Genes, pol ,Phylogenetic reconstruction ,Chronic infection ,Infectious Diseases ,Epidemiology ,Acute Disease ,medicine ,HIV-1 ,Immunology and Allergy ,Humans ,Female ,Phylogeny - Abstract
Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.
- Published
- 2009