2,414 results on '"Louis, David"'
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2. Language Instructors on Their Emergency Remote Teaching Pedagogy during the Pandemic
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Hamel, Marie-Josée, Landry, Jill, and Bibeau, Louis-David
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In this paper, we report on a study that took place during the COVID-19 pandemic and for which we interviewed ten experienced, university level, language instructors about their digital practices as they found themselves teaching in an Emergency Remote Teaching (ERT) mode. The study sought to describe how, through their professional activities and experiences, they developed new and/ or further online competencies and how the ERT context brought them to rethink their pedagogical practices and namely, their Written Corrective Feedback (WCF). Our results show that language instructors' digital competencies are on a dynamic continuum of changes with some who faced challenges, while others sought opportunities or provided solutions during that unprecedented period. An adapted version of the SAMR (Substitution, Augmentation, Modification, and Redefinition) model (Puentedura, 2010) is suggested, which takes into consideration this ERT context. [For the complete volume, "Intelligent CALL, Granular Systems and Learner Data: Short Papers from EUROCALL 2022 (30th, Reykjavik, Iceland, August 17-19, 2022)," see ED624779.]
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- 2022
3. Brain dynamics predictive of response to psilocybin for treatment-resistant depression.
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Vohryzek, Jakub, Cabral, Joana, Lord, Louis-David, Fernandes, Henrique, Roseman, Leor, Nutt, David, Carhart-Harris, Robin, Deco, Gustavo, and Kringelbach, Morten
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depression ,large-scale brain modelling ,psilocybin treatment - Abstract
Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here, we leveraged the differential outcome in responders and non-responders to psilocybin (10 and 25 mg, 7 days apart) therapy for depression-to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used large-scale brain modelling to fit the spatiotemporal brain dynamics at rest in both responders and non-responders before treatment. Dynamic sensitivity analysis of systematic perturbation of these models enabled us to identify specific brain regions implicated in a transition from a depressive brain state to a healthy one. Binarizing the sample into treatment responders (>50% reduction in depressive symptoms) versus non-responders enabled us to identify a subset of regions implicated in this change. Interestingly, these regions correlate with in vivo density maps of serotonin receptors 5-hydroxytryptamine 2a and 5-hydroxytryptamine 1a, which psilocin, the active metabolite of psilocybin, has an appreciable affinity for, and where it acts as a full-to-partial agonist. Serotonergic transmission has long been associated with depression, and our findings provide causal mechanistic evidence for the role of brain regions in the recovery from depression via psilocybin.
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- 2024
4. Rethinking Student Placement to Enhance Efficiency and Student Agency
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Beverly Baker, Angel Arias, Louis-David Bibeau, Yiwei Qin, Margret Norenberg, and Jennifer St-John
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Placement tests are used to support a particular need in a local context--to determine the best starting place for a student entering a specific programme of language study. This brief report will focus on the development of an innovative placement test with self-directed elements for our local needs at a university in Canada for students studying English or French as a second language. Our goals are to produce a more efficient assessment instrument while allowing students more agency through the process. We hope that sharing these details will encourage others to consider the potential of incorporating self-directed elements in low-stakes placement decision-making.
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- 2024
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5. Decision-making in organizations: should managers use AI?
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Brink, Anniek, Benyayer, Louis-David, and Kupp, Martin
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- 2024
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6. A National Dental Practice-Based Research Network phase II, cluster-randomized clinical trial assessing nicotine replacement therapy sampling in dental settings: study protocol for the Free Samples for Health (FreSH) study
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Fang, Pearl, Adkins-Hempel, Melissa, Lischka, Tamara, Basile, Sarah, Rindal, D. Brad, Carpenter, Matthew J., Kopycka-Kedzierawski, Dorota T., Dahne, Jennifer, Helseth, Sarah A., Levy, Douglas E., Truong, Arthur, Leo, Michael C., Funkhouser, Kimberly, Louis, David R., and Japuntich, Sandra J.
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- 2024
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7. Business Models for Mobility Data Sharing Platforms: Stakeholders’ Perceptions
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Benyayer, Louis-David, Bick, Markus, van der Aalst, Wil, Series Editor, Ram, Sudha, Series Editor, Rosemann, Michael, Series Editor, Szyperski, Clemens, Series Editor, Guizzardi, Giancarlo, Series Editor, Papadaki, Maria, editor, Themistocleous, Marinos, editor, Al Marri, Khalid, editor, and Al Zarouni, Marwan, editor
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- 2024
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8. Financial development, inclusive growth, and environmental quality: emerging markets perspective
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Annor, Louis David Junior, Robaina, Margarita, and Vieira, Elisabete
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- 2023
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9. Business Models for Mobility Data Sharing Platforms: Stakeholders’ Perceptions
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Benyayer, Louis-David, primary and Bick, Markus, additional
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- 2024
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10. Corporate social responsibility and performance among rural banks in Ghana: the moderating role of governance structures
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Agyapong, Elvis Kwame, Annor, Louis David Junior, and Ohemeng, Williams
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- 2024
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11. L’évaluation du français langue seconde : à quoi prépare-t-on vraiment les personnes immigrantes en francisation?
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Louis-David Bibeau, Naomie Fournier Dubé, Marie-Pier Forest, Gabrielle Adams, and Ariane Fiset
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Education - Abstract
L’apprentissage du français langue seconde au Canada, particulièrement au Québec, est une étape cruciale, mais complexe pour les personnes immigrantes. Bien que la francisation soit essentielle pour leur intégration, elle ne suffit pas. Les personnes immigrantes doivent aussi subir des épreuves évaluatives multiples pour faire reconnaitre leurs compétences professionnelles et linguistiques. Ce processus est souvent long, couteux et éprouvant, englobant des tests standardisés peu étudiés scientifiquement, ce qui soulève des questions sur leur véritable utilité. En somme, les cours de francisation semblent davantage préparer les immigrants à réussir ces tests qu’à une intégration fluide sur le marché du travail et dans la société canadienne.
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- 2024
12. Synthesis, antimicrobial activity, and mechanistic studies of enterocin DD14, a leaderless two-peptide bacteriocin
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Belguesmia, Yanath, Guay, Louis-David, Teiar, Radja, Rahman, Md Ramim Tanver, Dussert, Elodie, Biron, Eric, and Drider, Djamel
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- 2024
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13. p-type NiOx ultrathin film as highly efficient hole extraction layer in n-type PbS quantum dots based NIR photodiode
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Zouknak, Louis David Mohgouk, Gros-Jean, Mickael, Blonkowski, Serge, Leroux, Charles, and Ghibaudo, Gerard
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- 2024
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14. Business Models for Mobility Data Sharing Platforms: Stakeholders' Perceptions.
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Louis-David Benyayer and Markus Bick
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- 2023
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15. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
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Louis, David N, Perry, Arie, Wesseling, Pieter, Brat, Daniel J, Cree, Ian A, Figarella-Branger, Dominique, Hawkins, Cynthia, Ng, HK, Pfister, Stefan M, Reifenberger, Guido, Soffietti, Riccardo, von Deimling, Andreas, and Ellison, David W
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Brain Disorders ,Cancer ,Brain Cancer ,Rare Diseases ,Neurosciences ,Brain ,Central Nervous System ,Central Nervous System Neoplasms ,Humans ,Pathology ,Molecular ,World Health Organization ,brian tumor ,central nervous system ,classification ,diagnosis ,brain tumor ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the international standard for the classification of brain and spinal cord tumors. Building on the 2016 updated fourth edition and the work of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy, the 2021 fifth edition introduces major changes that advance the role of molecular diagnostics in CNS tumor classification. At the same time, it remains wedded to other established approaches to tumor diagnosis such as histology and immunohistochemistry. In doing so, the fifth edition establishes some different approaches to both CNS tumor nomenclature and grading and it emphasizes the importance of integrated diagnoses and layered reports. New tumor types and subtypes are introduced, some based on novel diagnostic technologies such as DNA methylome profiling. The present review summarizes the major general changes in the 2021 fifth edition classification and the specific changes in each taxonomic category. It is hoped that this summary provides an overview to facilitate more in-depth exploration of the entire fifth edition of the WHO Classification of Tumors of the Central Nervous System.
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- 2021
16. Reliability and minimal detectable change of dynamic temporal summation and conditioned pain modulation using a single experimental paradigm.
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Matthieu Vincenot, Louis-David Beaulieu, Louis Gendron, Serge Marchand, and Guillaume Léonard
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Medicine ,Science - Abstract
BackgroundQuantitative sensory tests (QST) are frequently used to explore alterations in somatosensory systems. Static and dynamic QST like pain threshold and temporal summation (TS) and conditioned pain modulation (CPM) are commonly used to evaluate excitatory and inhibitory mechanisms involved in pain processing. The aim of the present study was to document the reliability and the minimal detectable change (MDC) of these dynamic QST measurements using a standardized experimental paradigm.Material and methodsForty-six (46) pain-free participants took part in 2 identical sessions to collect TS and CPM outcomes. Mechanical (pressure pain threshold [PPT]) and thermal (constant 2-minute heat pain stimulation [HPS]) nociceptive stimuli were applied as test stimuli, before and after a cold-water bath (conditioning stimulus). TS was interpreted as the change in pain perception scores during HPS. CPM were determined by calculating the difference in pain perception between pre- and post- water bath for both PPT and HPS. Relative and absolute reliability were analyzed with intra-class correlation coefficient (ICC2, k), standard error of the measurements (SEMeas) and MDC.ResultsResults revealed a good to excellent relative reliability for static QST (ICC ≥ 0.73). For TS, a poor to moderate relative reliability depending on the calculation methods (ICC = 0.25 ≤ ICC ≤ 0.59), and a poor relative reliability for CPM (ICC = 0.16 ≤ ICC ≤ 0.37), both when measured with mechanical stimulation (PPT) and thermal stimulation (HPS). Absolute reliability varied from 0.73 to 7.74 for static QST, 11 to 22 points for TS and corresponded to 11.42 points and 1.56 points for thermal and mechanical-induced CPM, respectively. MDC analyses revealed that a change of 1.58 to 21.46 point for static QST, 31 to 52 points for TS and 4 to 31 points for CPM is necessary to be interpreted as a real change.ConclusionOur approach seems well-suited to clinical use. Although our method shows equivalent relative and absolute reliability compared to other protocols, we found that the reliability of endogenous pain modulation mechanisms is vulnerable, probably due to its dynamic nature.
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- 2024
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17. Challenges and opportunities in testing sensorimotor processing with tendon vibration and transcranial magnetic stimulation in subacromial impingement syndrome: A case series.
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Émilie Bouchard, Lydiane Lauzier, Mathieu Boudier-Revéret, Laurence Munger, Kossi Épiphane Ketounou, Marie-Pier Perron, Suzy Ngomo, Stéphane Sobczak, and Louis-David Beaulieu
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Medicine ,Science - Abstract
BackgroundNon-invasive neurostimulation like muscle tendon vibration (VIB) and transcranial magnetic stimulation (TMS) can provide valuable insights on mechanisms underlying sensorimotor dysfunctions. However, their feasibility in the context of painful musculoskeletal disorders like shoulder impingement syndrome (SIS) remain uncertain.MethodsThe present work used a case series design including 15 participants with SIS, as well as a secondary group-based analysis comparing participants with SIS to 15 healthy counterparts. Proprioceptive processing was tested by VIB-induced kinesthetic illusions of shoulder abduction, and TMS tested corticospinal excitability of the upper trapezius. Detailed individual data were collected, including any technical challenges and feasibility issues encountered.ResultsVIB was in general well-tolerated and elicited a perceptible kinesthetic illusion in 13 participants with SIS and 14 controls. TMS presented with several challenges related to discomfort, fear-related behaviors, technical problems and high motor thresholds, especially in participants with SIS. It was only possible to collect all TMS measures in 5 participants with SIS (for both the painful and non/less-painful sides), in 7 controls on their dominant side and 10 controls on the non-dominant side. The only significant group-based analysis was a lower illusion speed/amplitude on the painful versus non-painful side in persons with SIS (p = 0.035).ConclusionOur study provides preliminary data on challenges encountered with TMS and VIB of trunk/proximal muscle in persons with SIS and healthy counterparts. It might help future studies to better address those challenges beforehand and improve the overall feasibility and impact of neurostimulation tools in musculoskeletal disorders.
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- 2024
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18. Vibration-induced postural reactions: a scoping review on parameters and populations studied
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Michaël Bertrand-Charette, Marie-Pier Perron, Rubens A. da Silva, and Louis-David Beaulieu
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vibration ,proprioception ,postural reactions ,vibration parameters ,methodological rationale ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
ObjectiveMechanical vibration is an effective way for externally activating Ia primary endings of the muscle spindles and skin mechanoreceptors. Despite its popularity in proprioception and postural control studies, there is still no review covering the wide variety of vibration parameters or locations used in studies. The main purpose of this scoping review was thus to give an overview of general vibration parameters and to identify, if available, the rationale for justifying methodological choices concerning vibration parameters.MethodsThree databases (Pubmed, CINHAL, and SPORTDiscus) were searched from inception to July 2022. Included articles were to focus on the study of muscle spindles and skin mechanoreceptors vibration in humans and assess postural control. Following inclusion, data regarding demographic information, populations, vibration parameters and rationale were extracted and summarized.ResultsOne hundred forty-seven articles were included, mostly targeting lower extremities (n = 137) and adults (n = 126). The parameters used varied widely but were most often around 80 Hz, at an amplitude of 1 mm for 10–20 s. Regarding rationales, nearly 50% of the studies did not include any, whereas those including one mainly cited the same two studies, without elaborating specifically on the parameter's choice.ConclusionThis scoping review provided a comprehensive description of the population recruited and parameters used for vibration protocols in current studies with humans. Despite many studies, there remain important gaps of knowledge that needs to be filled, especially for vibration amplitude and duration parameters in various populations.
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- 2024
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19. Altered dynamical integration/segregation balance during anesthesia-induced loss of consciousness
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Louis-David Lord, Timoteo Carletti, Henrique Fernandes, Federico E. Turkheimer, and Paul Expert
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neural synchronisation ,ECoG ,altered state of consciousness ,integration/segregation ,anesthesia ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
In recent years, brain imaging studies have begun to shed light on the neural correlates of physiologically-reversible altered states of consciousness such as deep sleep, anesthesia, and psychedelic experiences. The emerging consensus is that normal waking consciousness requires the exploration of a dynamical repertoire enabling both global integration i.e., long-distance interactions between brain regions, and segregation, i.e., local processing in functionally specialized clusters. Altered states of consciousness have notably been characterized by a tipping of the integration/segregation balance away from this equilibrium. Historically, functional MRI (fMRI) has been the modality of choice for such investigations. However, fMRI does not enable characterization of the integration/segregation balance at sub-second temporal resolution. Here, we investigated global brain spatiotemporal patterns in electrocorticography (ECoG) data of a monkey (Macaca fuscata) under either ketamine or propofol general anesthesia. We first studied the effects of these anesthetics from the perspective of band-specific synchronization across the entire ECoG array, treating individual channels as oscillators. We further aimed to determine whether synchrony within spatially localized clusters of oscillators was differently affected by the drugs in comparison to synchronization over spatially distributed subsets of ECoG channels, thereby quantifying changes in integration/segregation balance on physiologically-relevant time scales. The findings reflect global brain dynamics characterized by a loss of long-range integration in multiple frequency bands under both ketamine and propofol anesthesia, most pronounced in the beta (13–30 Hz) and low-gamma bands (30–80 Hz), and with strongly preserved local synchrony in all bands.
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- 2023
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20. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
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Mathewson, Nathan D, Ashenberg, Orr, Tirosh, Itay, Gritsch, Simon, Perez, Elizabeth M, Marx, Sascha, Jerby-Arnon, Livnat, Chanoch-Myers, Rony, Hara, Toshiro, Richman, Alyssa R, Ito, Yoshinaga, Pyrdol, Jason, Friedrich, Mirco, Schumann, Kathrin, Poitras, Michael J, Gokhale, Prafulla C, Gonzalez Castro, L Nicolas, Shore, Marni E, Hebert, Christine M, Shaw, Brian, Cahill, Heather L, Drummond, Matthew, Zhang, Wubing, Olawoyin, Olamide, Wakimoto, Hiroaki, Rozenblatt-Rosen, Orit, Brastianos, Priscilla K, Liu, X Shirley, Jones, Pamela S, Cahill, Daniel P, Frosch, Matthew P, Louis, David N, Freeman, Gordon J, Ligon, Keith L, Marson, Alexander, Chiocca, E Antonio, Reardon, David A, Regev, Aviv, Suvà, Mario L, and Wucherpfennig, Kai W
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Rare Diseases ,Immunization ,Cancer ,Genetics ,Vaccine Related ,Brain Disorders ,Stem Cell Research ,Neurosciences ,Brain Cancer ,Human Genome ,Stem Cell Research - Nonembryonic - Human ,Animals ,Antigens ,Neoplasm ,Disease Models ,Animal ,Gene Expression Profiling ,Glioma ,Killer Cells ,Natural ,Lectins ,C-Type ,Lymphocytes ,Tumor-Infiltrating ,Mice ,NK Cell Lectin-Like Receptor Subfamily B ,Receptors ,Cell Surface ,Single-Cell Analysis ,T-Lymphocyte Subsets ,T-Lymphocytes ,Tumor Escape ,CD161 ,IDH-mutant gliomas ,T cells ,glioblastoma ,single-cell RNA-seq ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-seq) to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma. We identify potential effectors of anti-tumor immunity in subsets of T cells that co-express cytotoxic programs and several natural killer (NK) cell genes. Analysis of clonally expanded tumor-infiltrating T cells further identifies the NK gene KLRB1 (encoding CD161) as a candidate inhibitory receptor. Accordingly, genetic inactivation of KLRB1 or antibody-mediated CD161 blockade enhances T cell-mediated killing of glioma cells in vitro and their anti-tumor function in vivo. KLRB1 and its associated transcriptional program are also expressed by substantial T cell populations in other human cancers. Our work provides an atlas of T cells in gliomas and highlights CD161 and other NK cell receptors as immunotherapy targets.
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- 2021
21. Should an elective contralateral neck dissection be performed in midline-reaching squamous cell carcinomas of the oral cavity and oropharynx?
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Mattei, Pierre, Dghayem, Delphine, Dupret-Bories, Agnès, Sarini, Jérôme, Vairel, Benjamin, Rivière, Louis-David, Vergez, Sébastien, Lusque, Amélie, and Chabrillac, Emilien
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- 2023
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22. cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading
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Louis, David N, Wesseling, Pieter, Aldape, Kenneth, Brat, Daniel J, Capper, David, Cree, Ian A, Eberhart, Charles, Figarella‐Branger, Dominique, Fouladi, Maryam, Fuller, Gregory N, Giannini, Caterina, Haberler, Christine, Hawkins, Cynthia, Komori, Takashi, Kros, Johan M, Ng, HK, Orr, Brent A, Park, Sung‐Hye, Paulus, Werner, Perry, Arie, Pietsch, Torsten, Reifenberger, Guido, Rosenblum, Marc, Rous, Brian, Sahm, Felix, Sarkar, Chitra, Solomon, David A, Tabori, Uri, Bent, Martin J, Deimling, Andreas, Weller, Michael, White, Valerie A, and Ellison, David W
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Rare Diseases ,Central Nervous System Neoplasms ,Humans ,Neoplasm Grading ,brain tumors ,central nervous system ,classification ,neoplasms ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles-relating to classification categories, approaches to classification, nomenclature, and grading-that the group hopes will also inform the future classification of CNS neoplasms.
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- 2020
23. Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.
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Lee, Bomi, Adamska, Julia, Namkoong, Hong, Bellin, Melena, Wilhelm, Josh, Szot, Gregory, Louis, David, Davis, Mark, Pandol, Stephen, and Habtezion, Aida
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Cellular immune response ,Gastroenterology ,Immunology ,Macrophages ,T-cell receptor ,Antigens ,CD ,Antigens ,Differentiation ,Myelomonocytic ,Female ,Genes ,T-Cell Receptor beta ,Humans ,Macrophages ,Male ,Pancreas ,Pancreatitis ,Chronic ,Receptors ,Antigen ,T-Cell ,alpha-beta ,T-Lymphocyte Subsets - Abstract
Chronic pancreatitis (CP) is considered an irreversible fibroinflammatory pancreatic disease. Despite numerous animal model studies, questions remain about local immune characteristics in human CP. We profiled pancreatic immune cell characteristics in control organ donors and CP patients including those with hereditary and idiopathic CP undergoing total pancreatectomy with islet autotransplantation. Flow cytometric analysis revealed a significant increase in the frequency of CD68+ macrophages in idiopathic CP. In contrast, hereditary CP samples showed a significant increase in CD3+ T cell frequency, which prompted us to investigate the T cell receptor β (TCRβ) repertoire in the CP and control groups. TCRβ sequencing revealed a significant increase in TCRβ repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vβ-Jβ gene family usage between hereditary and idiopathic CP and a positive correlation of TCRβ rearrangements with disease severity scores. Immunophenotyping analyses in hereditary and idiopathic CP pancreases indicate differences in innate and adaptive immune responses, which highlights differences in immunopathogenic mechanisms of disease among subtypes of CP. TCR repertoire analysis further suggests a role for specific T cell responses in hereditary versus idiopathic CP pathogenesis, providing insights into immune responses associated with human CP.
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- 2020
24. Pan-cancer analysis of whole genomes
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Campbell, Peter J, Getz, Gad, Korbel, Jan O, Stuart, Joshua M, Jennings, Jennifer L, Stein, Lincoln D, Perry, Marc D, Nahal-Bose, Hardeep K, Ouellette, BF Francis, Li, Constance H, Rheinbay, Esther, Nielsen, G Petur, Sgroi, Dennis C, Wu, Chin-Lee, Faquin, William C, Deshpande, Vikram, Boutros, Paul C, Lazar, Alexander J, Hoadley, Katherine A, Louis, David N, Dursi, L Jonathan, Yung, Christina K, Bailey, Matthew H, Saksena, Gordon, Raine, Keiran M, Buchhalter, Ivo, Kleinheinz, Kortine, Schlesner, Matthias, Zhang, Junjun, Wang, Wenyi, Wheeler, David A, Ding, Li, Simpson, Jared T, O'Connor, Brian D, Yakneen, Sergei, Ellrott, Kyle, Miyoshi, Naoki, Butler, Adam P, Royo, Romina, Shorser, Solomon I, Vazquez, Miguel, Rausch, Tobias, Tiao, Grace, Waszak, Sebastian M, Rodriguez-Martin, Bernardo, Shringarpure, Suyash, Wu, Dai-Ying, Demidov, German M, Delaneau, Olivier, Hayashi, Shuto, Imoto, Seiya, Habermann, Nina, Segre, Ayellet V, Garrison, Erik, Cafferkey, Andy, Alvarez, Eva G, Maria Heredia-Genestar, Jose, Muyas, Francesc, Drechsel, Oliver, Bruzos, Alicia L, Temes, Javier, Zamora, Jorge, Baez-Ortega, Adrian, Kim, Hyung-Lae, Mashl, R Jay, Ye, Kai, DiBiase, Anthony, Huang, Kuan-lin, Letunic, Ivica, McLellan, Michael D, Newhouse, Steven J, Shmaya, Tal, Kumar, Sushant, Wedge, David C, Wright, Mark H, Yellapantula, Venkata D, Gerstein, Mark, Khurana, Ekta, Marques-Bonet, Tomas, Navarro, Arcadi, Bustamante, Carlos D, Siebert, Reiner, Nakagawa, Hidewaki, Easton, Douglas F, Ossowski, Stephan, Tubio, Jose MC, De La Vega, Francisco M, Estivill, Xavier, Yuen, Denis, Mihaiescu, George L, Omberg, Larsson, Ferretti, Vincent, Sabarinathan, Radhakrishnan, Pich, Oriol, Gonzalez-Perez, Abel, Weiner, Amaro Taylor, Fittall, Matthew W, Demeulemeester, Jonas, Tarabichi, Maxime, and Roberts, Nicola D
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Biological Sciences ,Biomedical and Clinical Sciences ,Bioinformatics and Computational Biology ,Genetics ,Oncology and Carcinogenesis ,Cancer Genomics ,Biotechnology ,Human Genome ,Cancer ,Prevention ,2.1 Biological and endogenous factors ,Cell Proliferation ,Cellular Senescence ,Chromothripsis ,Cloud Computing ,DNA Mutational Analysis ,Evolution ,Molecular ,Female ,Genome ,Human ,Genomics ,Germ-Line Mutation ,High-Throughput Nucleotide Sequencing ,Humans ,Information Dissemination ,Male ,Mutagenesis ,Mutation ,Neoplasms ,Oncogenes ,Promoter Regions ,Genetic ,RNA Splicing ,Reproducibility of Results ,Telomerase ,Telomere ,ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium ,General Science & Technology - Abstract
Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10-18.
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- 2020
25. Dynamic sensitivity analysis: Defining personalised strategies to drive brain state transitions via whole brain modelling
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Jakub Vohryzek, Joana Cabral, Francesca Castaldo, Yonatan Sanz-Perl, Louis-David Lord, Henrique M. Fernandes, Vladimir Litvak, Morten L. Kringelbach, and Gustavo Deco
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Spatio-temporal dynamics ,Brain stimulation ,Whole-brain models ,Brain State ,Biotechnology ,TP248.13-248.65 - Abstract
Traditionally, in neuroimaging, model-free analyses are used to find significant differences between brain states via signal detection theory. Depending on the a priori assumptions about the underlying data, different spatio-temporal features can be analysed. Alternatively, model-based techniques infer features from the data and compare significance from model parameters. However, to assess transitions from one brain state to another remains a challenge in current paradigms. Here, we introduce a “Dynamic Sensitivity Analysis” framework that quantifies transitions between brain states in terms of stimulation ability to rebalance spatio-temporal brain activity towards a target state such as healthy brain dynamics. In practice, it means building a whole-brain model fitted to the spatio-temporal description of brain dynamics, and applying systematic stimulations in-silico to assess the optimal strategy to drive brain dynamics towards a target state. Further, we show how Dynamic Sensitivity Analysis extends to various brain stimulation paradigms, ultimately contributing to improving the efficacy of personalised clinical interventions.
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- 2023
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26. The Cardiovascular Manifestations of COVID-19
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Louis, David W., Saad, Marwan, Vijayakumar, Shilpa, Ilyas, Suleman, Kokkirala, Aravind, and Aronow, Herbert D.
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- 2023
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27. Language instructors on their emergency remote teaching pedagogy during the pandemic
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Hamel, Marie-Josée, primary, Landry, Jill, additional, and Bibeau, Louis-David, additional
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- 2022
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28. Dynamic sensitivity analysis: Defining personalised strategies to drive brain state transitions via whole brain modelling
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Vohryzek, Jakub, Cabral, Joana, Castaldo, Francesca, Sanz-Perl, Yonatan, Lord, Louis-David, Fernandes, Henrique M., Litvak, Vladimir, Kringelbach, Morten L., and Deco, Gustavo
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- 2023
- Full Text
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29. Multiple Mycobacterium abscessus O-acetyltransferases influence glycopeptidolipid structure and colony morphotype
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Illouz, Morgane, Leclercq, Louis-David, Dessenne, Clara, Hatfull, Graham, Daher, Wassim, Kremer, Laurent, and Guérardel, Yann
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- 2023
- Full Text
- View/download PDF
30. Information technology investment and rural bank performance in Ghana: the moderating role of ICT diffusion and financial development
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Annor, Louis David Junior, primary, Agyapong, Elvis Kwame, additional, Robaina, Margarita, additional, Vieira, Elisabete, additional, and Anarfo, Ebenezer Bugri, additional
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- 2024
- Full Text
- View/download PDF
31. Antimicrobial Activity of Synthetic Enterocins A, B, P, SEK4, and L50, Alone and in Combinations, against Clostridium perfringens
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Sara García-Vela, Louis-David Guay, Md Ramim Tanver Rahman, Eric Biron, Carmen Torres, and Ismail Fliss
- Subjects
enterocins ,antimicrobial activity ,Clostridium perfringens ,chemical synthesis ,synergy ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Multidrug-resistant Clostridium perfringens infections are a major threat to the poultry industry. Effective alternatives to antibiotics are urgently needed to prevent these infections and limit the spread of multidrug-resistant bacteria. The aim of the study was to produce by chemical synthesis a set of enterocins of different subgroups of class II bacteriocins and to compare their spectrum of inhibitory activity, either alone or in combination, against a panel of twenty C. perfringens isolates. Enterocins A, P, SEK4 (class IIa bacteriocins), B (unsubgrouped class II bacteriocin), and L50 (class IId leaderless bacteriocin) were produced by microwave-assisted solid-phase peptide synthesis. Their antimicrobial activity was determined by agar well diffusion and microtitration methods against twenty C. perfringens isolates and against other pathogens. The FICINDEX of different combinations of the selected enterocins was calculated in order to identify combinations with synergistic effects. The results showed that synthetic analogs of L50A and L50B were the most active against C. perfringens. These peptides also showed the broadest spectrum of activity when tested against other non-clostridial indicator strains, including Listeria monocytogenes, methicillin-resistant Staphylococcus aureus, Streptococcus suis, Streptococcus pyogenes, Enterococcus cecorum, Enterococcus faecalis, as well as Gram-negative bacteria (Campylobacter coli and Pseudomonas aeruginosa), among others. The selected synthetic enterocins were combined on the basis of their different mechanisms of action, and all combinations tested showed synergy or partial synergy against C. perfringens. In conclusion, because of their high activity against C. perfringens and other pathogens, the use of synthetic enterocins alone or as a consortium can be a good alternative to the use of antibiotics in the poultry sector.
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- 2024
- Full Text
- View/download PDF
32. Opposing T cell responses in experimental autoimmune encephalomyelitis.
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Saligrama, Naresha, Zhao, Fan, Sikora, Michael J, Serratelli, William S, Fernandes, Ricardo A, Louis, David M, Yao, Winnie, Ji, Xuhuai, Idoyaga, Juliana, Mahajan, Vinit B, Steinmetz, Lars M, Chien, Yueh-Hsiu, Hauser, Stephen L, Oksenberg, Jorge R, Garcia, K Christopher, and Davis, Mark M
- Subjects
T-Lymphocytes ,CD4-Positive T-Lymphocytes ,CD8-Positive T-Lymphocytes ,Clone Cells ,Animals ,Mice ,Inbred C57BL ,Humans ,Mice ,Celiac Disease ,Encephalomyelitis ,Autoimmune ,Experimental ,Myelin-Associated Glycoprotein ,Receptors ,Antigen ,T-Cell ,H-2 Antigens ,Immunization ,Lymphocyte Activation ,Adult ,Middle Aged ,Female ,Male ,T-Lymphocytes ,Regulatory ,Young Adult ,Inbred C57BL ,Encephalomyelitis ,Autoimmune ,Experimental ,Receptors ,Antigen ,T-Cell ,Regulatory ,General Science & Technology - Abstract
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8+ T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4+ T cells are specific for the inducing myelin peptide MOG35-55. By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8+ T cells inhibit disease by suppressing the proliferation of MOG-specific CD4+ T cells. These results suggest that the induction of autoreactive CD4+ T cells triggers an opposing mobilization of regulatory CD8+ T cells.
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- 2019
33. cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates.
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Louis, David N, Ellison, David W, Brat, Daniel J, Aldape, Kenneth, Capper, David, Hawkins, Cynthia, Paulus, Werner, Perry, Arie, Reifenberger, Guido, Figarella-Branger, Dominique, von Deimling, Andreas, and Wesseling, Pieter
- Subjects
Humans ,Central Nervous System Neoplasms ,Brain Neoplasms ,Neuropathology ,Brain Cancer ,Brain Disorders ,Neurosciences ,Rare Diseases ,Cancer ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to provide a forum to evaluate and recommend proposed changes to future CNS tumor classifications. From 2016 to 2019 (Round 1), cIMPACT published four updates. Update 1 clarified the use of the term NOS (Not Otherwise Specified) and proposed use of the additional term NEC (Not Elsewhere Classified). Update 2 issued clarifications regarding two diagnoses: Diffuse Midline Glioma, H3 K27M-mutant and Diffuse Astrocytoma/Anaplastic Astrocytoma, IDH-mutant. Update 3 proposed molecular criteria that could be used in the setting of an IDH-wildtype diffuse or anaplastic astrocytic glioma without histological features of glioblastoma to infer that the tumor would behave similarly to a grade IV glioblastoma. Update 4 suggested that, in children and young adults, subtypes of IDH-wildtype/H3-wildtype diffuse gliomas may have distinct clinical features in the setting of a BRAFV600E mutation, FGFR1 alteration, other MAPK pathway alteration, or a MYB or MYBL1 rearrangement. The practical diagnostic relevance of these cIMPACT proposals is highlighted in this summary.
- Published
- 2019
34. The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.
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Fritchie, Karen, Jensch, Kassandra, Moskalev, Evgeny A, Caron, Alissa, Jenkins, Sarah, Link, Michael, Brown, Paul D, Rodriguez, Fausto J, Guajardo, Andrew, Brat, Daniel, Velázquez Vega, José E, Perry, Arie, Wu, Ashley, Raleigh, David R, Santagata, Sandro, Louis, David N, Brastianos, Priscilla K, Kaplan, Alexander, Alexander, Brian M, Rossi, Sabrina, Ferrarese, Fabio, Haller, Florian, and Giannini, Caterina
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Humans ,Hemangiopericytoma ,Meningeal Neoplasms ,Neoplasm Recurrence ,Local ,Repressor Proteins ,Gene Fusion ,Adolescent ,Adult ,Aged ,Middle Aged ,Female ,Male ,Solitary Fibrous Tumors ,Young Adult ,Neoplasm Grading ,Meningeal hemangiopericytoma ,Meningeal solitary fibrous tumor ,NAB2–STAT6 ,STAT6 ,NAB2-STAT6 ,Neoplasm Recurrence ,Local ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare tumor with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratification remains unclear, and the prognostic impact of fusion status is uncertain. We compared the 2016 WHO CNS tumor grading scheme (CNS-G), a three-tier system based on histopathologic phenotype and mitotic count, to the 2013 WHO soft-tissue counterpart (ST-G), a two-tier system based on mitotic count alone, in a cohort of 133 patients [59 female, 74 male; mean age 54 years (range 20-87)] with meningeal SFT/HPC. Tumors were pathologically confirmed through review of the first tumor resection (n = 97), local recurrence (n = 35), or distant metastasis (n = 1). A STAT6 immunostain showed nuclear expression in 132 cases. NAB2-STAT6 fusion was detected in 99 of 111 successfully tested tumors (89%) including the single STAT6 immunonegative tumor. Tumors were classified by CNS-G as grade 1 (n = 43), 2 (n = 41), or 3 (n = 49), and by ST-G as SFT (n = 84) or malignant SFT (n = 49). Necrosis was present in 16 cases (12%). On follow-up, 42 patients had at least one subsequent recurrence or metastasis (7 metastasis only, 33 recurrence only, 2 patients had both). Twenty-nine patients died. On univariate analysis, necrosis (p = 0.002), CNS-G (p = 0.01), and ST-G (p = 0.004) were associated with recurrence-free (RFS) but not overall survival (OS). NAB2-STAT6 fusion type was not significantly associated with RFS or OS, but was associated with phenotype. A modified ST-G incorporating necrosis showed higher correlation with RFS (p = 0.0006) and remained significant (p = 0.02) when considering only the primary tumors. From our data, mitotic rate and necrosis appear to stratify this family of tumors most accurately and could be incorporated in a future grading scheme.
- Published
- 2019
35. Neural circuits activated by error amplification and haptic guidance training techniques during performance of a timing-based motor task by healthy individuals.
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Milot, Marie-Hélène, Marchal-Crespo, Laura, Beaulieu, Louis-David, Reinkensmeyer, David J, and Cramer, Steven C
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Adult ,Brain: diagnostic imaging ,physiology ,Feedback ,Physiological: physiology ,Female ,Functional Neuroimaging ,Humans ,Learning: physiology ,Magnetic Resonance Imaging ,Male ,Motor Skills: physiology ,Robotics ,Young Adult - Abstract
To promote motor learning, robotic devices have been used to improve subjects' performance by guiding desired movements (haptic guidance-HG) or by artificially increasing movement errors to foster a more rapid learning (error amplification-EA). To better understand the neurophysiological basis of motor learning, a few studies have evaluated brain regions activated during EA/HG, but none has compared both approaches. The goal of this study was to investigate using fMRI which brain networks were activated during a single training session of HG/EA in healthy adults learning to play a computerized pinball-like timing task. Subjects had to trigger a robotic device by flexing their wrist at the correct timing to activate a virtual flipper and hit a falling ball towards randomly positioned targets. During training with HG/EA, subjects' timing errors were decreased/increased, respectively, by the robotic device to delay or accelerate their wrist movement. The results showed that at the beginning of the training period with HG/EA, an error-detection network, including cerebellum and angular gyrus, was activated, consistent with subjects recognizing discrepancies between their intended actions and the actual movement timing. At the end of the training period, an error-detection network was still present for EA, while a memory consolidation/automatization network (caudate head and parahippocampal gyrus) was activated for HG. The results indicate that training movement with various kinds of robotic input relies on different brain networks. Better understanding the neurophysiological underpinnings of brain processes during HG/EA could prove useful for optimizing rehabilitative movement training for people with different patterns of brain damage.
- Published
- 2018
36. The Cardiovascular Manifestations of COVID-19
- Author
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Louis, David W., Saad, Marwan, Vijayakumar, Shilpa, Ilyas, Suleman, Kokkirala, Aravind, and Aronow, Herbert D.
- Published
- 2022
- Full Text
- View/download PDF
37. Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus
- Author
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Daher, Wassim, Leclercq, Louis-David, Johansen, Matt D., Hamela, Claire, Karam, Jona, Trivelli, Xavier, Nigou, Jérôme, Guérardel, Yann, and Kremer, Laurent
- Published
- 2022
- Full Text
- View/download PDF
38. Integration and segregation in whole-brain networks : implications for altered states of consciousness
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Lord, Louis-David, Kringelbach, Morten, and Lambiotte, Renaud
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612.8 - Abstract
To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must also balance its ability to integrate information with a complementary capacity to segregate information into modules which perform specialized computations in local circuits. The central focus of this Thesis is to investigate the dynamical properties of the integration/segregation balance in functional MRI data collected in two distinct altered states of consciousness: slow-wave sleep, and a psychedelic experience induced by intravenously administering psilocybin; the psychoactive compound in "magic mushrooms". In Chapter 2, I implement a novel method for identifying highly integrative nodes in human brain networks from the persistent homology of fMRI data, as a complement to standard graph theoretical methods. I report that topologically central nodes in the 'persistence homological scaffold' have a combination of high betweenness-centrality and high participation coefficient, whilst simultaneously avoiding densely connected neighborhood clusters. In Chapter 3, I investigate dynamical changes in global measures of functional integration and segregation derived from fMRI data. Synchrony, metastability and chimeraness metrics are computed separately in slow-wave sleep and in the psychedelic state. It is found that global synchrony and metastability are reduced in slow-wave sleep relative to a wakeful rest baseline, whilst chimeraness is increased. Diametrically opposite effects on each measure are observed in the psychedelic state. Chapter 4 characterizes the brain's dynamical landscape from a system-level perspective under psilocybin by computing the fractional occupancy and transition probabilities of specific functional network states over time. An increase in the probability of occurrence of a globally coherent functional connectivity state is observed, alongside a strong decrease in the fractional occupancy of a fronto-parietal control network. In Chapter 5, I further characterize the capacity of brain areas to dynamically broadcast regional activity signals locally or globally in both deep sleep and the psychedelic state. The results notably show that intrinsic activity perturbations in a given brain area are more likely to propagate strictly locally in slow-wave sleep than during wakeful rest. In the psychedelic state, the size of integration cascades elicited by local perturbations over time is significantly more variable than during the baseline scan. The experimental findings presented in this Thesis indicate that alterations in consciousness level and/or contents are accompanied by temporally-dependent changes in the brain's integration and segregation balance, promoting cross-modular integration in the psychedelic state, and functionally segregated brain dynamics in slow-wave sleep.
- Published
- 2018
39. Criterion Validation of an Open-source Wearable Physiological Sensors Device.
- Author
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Antoine Langevin, William Bégin, Martin Lavallière, Louis-David Beaulieu, Bob-Antoine Jerry Ménélas, Sébastien Gaboury, Kevin Bouchard, Ghyslain Gagnon, and Linda Paquette
- Published
- 2021
- Full Text
- View/download PDF
40. Distinctive phases and variability of vibration-induced postural reactions highlighted by center of pressure analysis.
- Author
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Mohamed Abdelhafid Kadri, Emilie Bouchard, Lydiane Lauzier, Hakim Mecheri, William Bégin, Martin Lavallière, Hugo Massé-Alarie, Rubens A da Silva, and Louis-David Beaulieu
- Subjects
Medicine ,Science - Abstract
BackgroundThe vibration-induced postural reaction paradigm (VIB-PR) offers a unique way for investigating sensorimotor control mechanisms. Measures of VIB-PR are usually calculated from the whole VIB period, yet recent evidence proposed that distinctive mechanisms are likely at play between the early vs. later phases of the postural reaction.ObjectivesThe present work verified if spatiotemporal analyses of center of pressure (COP) displacements can detect differences between these early/later phases of VIB-PR. Also, we further characterized the intra/inter-individual variability of COP measurements, since the underlying variability of VIB-PR remains largely unexplored.MethodsTwenty young volunteers realized two experimental conditions of bipodal stance with eyes closed: (i) bilateral VIB of tibialis anterior (TIB) and (ii) Achilles' (ACH) tendons. Each condition consisted of five trials and lasted 30 s as follows: 10 s baseline, 10 s VIB and 10 s post-VIB. Linear COP variables (antero-posterior (AP) amplitude & velocity) were computed for both VIB and post-VIB periods using the following time-windows: early 2 s, the later 8 s and the whole 10 s duration. Intra- and inter-individual variability were respectively estimated using the standard error of the measurement and the coefficient of variation. Both variability metrics were obtained using five vs. the first three trials.ResultsSignificant contrasts were found between time-windows for both VIB and post-VIB periods. COP variables were generally higher during the early 2 s phase compared to the later 8 s phase for both TIB [mean difference between 8 s- 2 s phases: Amplitude AP = -1.11 ± 1.14 cm during VIB and -2.99 ± 1.31 during post-VIB; Velocity AP = -1.17 ± 0.86 cm/s during VIB and -3.13 ± 1.31 cm/s during post-VIB] and ACH tendons [Amplitude AP = -0.37 ± 0.98 cm during VIB and -3.41 ± 1.20 during post-VIB; Velocity AP = -0.31 ± 0.59 cm/s during VIB and -3.89 ± 1.52 cm/s during post-VIB]. Most within- and between-subject variability scores were below 30% and using three instead of five trials had no impact on variability. VIB-PR patterns were quite similar within a same person, but variable behaviors were observed between individuals during the later phase.ConclusionOur study highlights the relevance of identifying and separately analyzing distinct phases within VIB-PR patterns, as well as characterizing how these patterns vary at the individual level.
- Published
- 2023
- Full Text
- View/download PDF
41. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
- Author
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Goode, Benjamin, Mondal, Gourish, Hyun, Michael, Ruiz, Diego Garrido, Lin, Yu-Hsiu, Van Ziffle, Jessica, Joseph, Nancy M, Onodera, Courtney, Talevich, Eric, Grenert, James P, Hewedi, Iman H, Snuderl, Matija, Brat, Daniel J, Kleinschmidt-DeMasters, Bette K, Rodriguez, Fausto J, Louis, David N, Yong, William H, Lopes, M Beatriz, Rosenblum, Marc K, Butowski, Nicholas, Tihan, Tarik, Bollen, Andrew W, Phillips, Joanna J, Wiita, Arun P, Yeh, Iwei, Jacobson, Matthew P, Bastian, Boris C, Perry, Arie, and Solomon, David A
- Subjects
Third Ventricle ,Humans ,Glioma ,Cerebral Ventricle Neoplasms ,Extracellular Signal-Regulated MAP Kinases ,Phosphorylation ,Mutation ,Missense ,Adult ,Aged ,Middle Aged ,Female ,Male ,Protein Kinase C-alpha ,Protein Domains - Abstract
Chordoid glioma is a rare brain tumor thought to arise from specialized glial cells of the lamina terminalis along the anterior wall of the third ventricle. Despite being histologically low-grade, chordoid gliomas are often associated with poor outcome, as their stereotypic location in the third ventricle makes resection challenging and efficacious adjuvant therapies have not been developed. Here we performed genomic profiling on 13 chordoid gliomas and identified a recurrent D463H missense mutation in PRKCA in all tumors, which localizes in the kinase domain of the encoded protein kinase C alpha (PKCα). Expression of mutant PRKCA in immortalized human astrocytes led to increased phospho-ERK and anchorage-independent growth that could be blocked by MEK inhibition. These studies define PRKCA as a recurrently mutated oncogene in human cancer and identify a potential therapeutic vulnerability in this uncommon brain tumor.
- Published
- 2018
42. A National Dental Practice-Based Research Network phase II, cluster-randomized clinical trial assessing nicotine replacement therapy sampling in dental settings: Study protocol for the Free Samples for Health (FreSH) study
- Author
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Fang, Pearl, primary, Adkins-Hempel, Melissa, additional, Lischka, Tamara, additional, Basile, Sarah, additional, Rindal, D. Brad, additional, Carpenter, Matthew J., additional, Kopycka-Kedzierawski, Dorota T., additional, Dahne, Jennifer, additional, Helseth, Sarah A., additional, Levy, Douglas E., additional, Truong, Arthur, additional, Leo, Michael C., additional, Funkhouser, Kimberly, additional, Louis, David, additional, and Japuntich, Sandra, additional
- Published
- 2024
- Full Text
- View/download PDF
43. Abstract 10384: Impact of Preexisting Pulmonary Hypertension on Outcomes in Patients Hospitalized With Covid-19
- Author
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Louis, David, Sheikh, Wasiq, Saad, Marwan, Has, Phinnara, kennedy, kevin, Aronow, Herbert D, and Choudhary, Gaurav
- Published
- 2022
- Full Text
- View/download PDF
44. Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study
- Author
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Sfeir, Rony, Rousseau, Veronique, Bonnard, Arnaud, Gelas, Thomas, Aumar, Madeleine, Panait, Nicoleta, Piolat, Christian, Irtan, Sabine, Fouquet, Virginie, Lemandat, Aurelie, De Napoli, Stephan, Habonimana, Edouard, Lamireau, Thierry, Lemelle, Jean Louis, El Baz, Frederic, Talon, Isabelle, Polimerol, Marie Laurence, Allal, Hussein, Buisson, Philippe, Petit, Thierry, Louis, David, Lardy, Hubert, Schmitt, Francoise, Levard, Guillaume, Scalabre, Aurélien, Michel, Jean Luc, Jaby, Olivier, Pelatan, Cecile, De Vries, Philine, Borderon, Corinne, Fourcade, Laurent, Breaud, Jean, Pouzac, Myriam, Tolg, Cecilia, Chaussy, Yann, Ritz, Sandy Jochault, Laplace, Christophe, Drumez, Elodie, and Gottrand, Frederic
- Published
- 2021
- Full Text
- View/download PDF
45. The bottom-up approach: Non-invasive peripheral neurostimulation methods to treat migraine: A scoping review from the child neurologist's perspective
- Author
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Börner, Corinna, Urban, Giada, Beaulieu, Louis-David, Sollmann, Nico, Krieg, Sandro M., Straube, Andreas, Renner, Tabea, Schandelmaier, Paul, Lang, Magdalena, Lechner, Matthias, Vill, Katharina, Gerstl, Lucia, Heinen, Florian, Landgraf, Mirjam N., and Bonfert, Michaela V.
- Published
- 2021
- Full Text
- View/download PDF
46. Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas
- Author
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Shankar, Ganesh M, Abedalthagafi, Malak, Vaubel, Rachael A, Merrill, Parker H, Nayyar, Naema, Gill, Corey M, Brewster, Ryan, Bi, Wenya Linda, Agarwalla, Pankaj K, Thorner, Aaron R, Reardon, David A, Al-Mefty, Ossama, Wen, Patrick Y, Alexander, Brian M, van Hummelen, Paul, Batchelor, Tracy T, Ligon, Keith L, Ligon, Azra H, Meyerson, Matthew, Dunn, Ian F, Beroukhim, Rameen, Louis, David N, Perry, Arie, Carter, Scott L, Giannini, Caterina, Curry, William T, Cahill, Daniel P, Barker, Frederick G, Brastianos, Priscilla K, and Santagata, Sandro
- Subjects
Cancer ,Rare Diseases ,Clinical Research ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Disease Progression ,Germ-Line Mutation ,Humans ,Meningeal Neoplasms ,Meningioma ,Mutation ,Neoplasm Grading ,Rhabdoid Tumor ,Survival Analysis ,Tumor Suppressor Proteins ,Ubiquitin Thiolesterase ,BAP1 ,exome sequencing ,rhabdoid meningiomas ,Neurosciences ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundPatients with meningiomas have widely divergent clinical courses. Some entirely recover following surgery alone, while others have relentless tumor recurrences. This clinical conundrum is exemplified by rhabdoid meningiomas, which are designated in the World Health Organization Classification of Tumours as high grade, despite only a subset following an aggressive clinical course. Patient management decisions are further exacerbated by high rates of interobserver variability, biased against missing possibly aggressive tumors. Objective molecular determinants are needed to guide classification and clinical decision making.MethodsTo define genomic aberrations of rhabdoid meningiomas, we performed sequencing of cancer-related genes in 27 meningiomas from 18 patients with rhabdoid features and evaluated breast cancer [BRCA]1-associated protein 1 (BAP1) expression by immunohistochemistry in 336 meningiomas. We assessed outcomes, germline status, and family history in patients with BAP1-negative rhabdoid meningiomas.ResultsThe tumor suppressor gene BAP1, a ubiquitin carboxy-terminal hydrolase, is inactivated in a subset of high-grade rhabdoid meningiomas. Patients with BAP1-negative rhabdoid meningiomas had reduced time to recurrence compared with patients with BAP1-retained rhabdoid meningiomas (Kaplan-Meier analysis, 26 mo vs 116 mo, P < .001; hazard ratio 12.89). A subset of patients with BAP1-deficient rhabdoid meningiomas harbored germline BAP1 mutations, indicating that rhabdoid meningiomas can be a harbinger of the BAP1 cancer predisposition syndrome.ConclusionWe define a subset of aggressive rhabdoid meningiomas that can be recognized using routine laboratory tests. We implicate ubiquitin deregulation in the pathogenesis of these high-grade malignancies. In addition, we show that familial and sporadic BAP1-mutated rhabdoid meningiomas are clinically aggressive, requiring intensive clinical management.
- Published
- 2017
47. Here There Be JAGUARS.
- Author
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Louis, David C.
- Subjects
ANIMAL behavior ,PUMAS ,GEOGRAPHIC information systems ,DIGITAL cameras ,TROPICAL ecosystems ,JAGUAR - Abstract
This article discusses the use of camera traps to study the secret life of jaguars in the Northern Jaguar Reserve in Sonora, Mexico. The reserve is a diverse ecosystem that is home to various species, including jaguars, ocelots, and other wildlife. Biologists use camera traps to capture photos of these animals, which helps them understand their behavior and habitat preferences. The non-invasive nature of camera traps allows scientists to study animals without causing harm or stress. The data collected from camera traps, along with mapping tools, can be used to protect jaguar habitats and identify wildlife corridors. [Extracted from the article]
- Published
- 2024
48. An open vibration and pressure platform for fall prevention with a reinforcement learning agent.
- Author
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Virgile Lafontaine, Patrick Lapointe, Kevin Bouchard, Jean-Michel Gagnon, Mathieu Dallaire, Sébastien Gaboury, Rubens A. da Silva, and Louis-David Beaulieu
- Published
- 2021
- Full Text
- View/download PDF
49. An open vibration and pressure platform for fall prevention with a reinforcement learning agent
- Author
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Lafontaine, Virgile, Lapointe, Patrick, Bouchard, Kevin, Gagnon, Jean-Michel, Dallaire, Mathieu, Gaboury, Sébastien, da Silva, Rubens A., and Beaulieu, Louis-David
- Published
- 2021
- Full Text
- View/download PDF
50. Reliability and minimal detectable change of dynamic temporal summation and conditioned pain modulation using a single experimental paradigm.
- Author
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Vincenot, Matthieu, Beaulieu, Louis-David, Gendron, Louis, Marchand, Serge, and Léonard, Guillaume
- Subjects
- *
PAIN perception , *MEASUREMENT errors , *INTRACLASS correlation , *UNITS of measurement , *PAIN threshold , *STATISTICAL correlation - Abstract
Background: Quantitative sensory tests (QST) are frequently used to explore alterations in somatosensory systems. Static and dynamic QST like pain threshold and temporal summation (TS) and conditioned pain modulation (CPM) are commonly used to evaluate excitatory and inhibitory mechanisms involved in pain processing. The aim of the present study was to document the reliability and the minimal detectable change (MDC) of these dynamic QST measurements using a standardized experimental paradigm. Material and methods: Forty-six (46) pain-free participants took part in 2 identical sessions to collect TS and CPM outcomes. Mechanical (pressure pain threshold [PPT]) and thermal (constant 2-minute heat pain stimulation [HPS]) nociceptive stimuli were applied as test stimuli, before and after a cold-water bath (conditioning stimulus). TS was interpreted as the change in pain perception scores during HPS. CPM were determined by calculating the difference in pain perception between pre- and post- water bath for both PPT and HPS. Relative and absolute reliability were analyzed with intra-class correlation coefficient (ICC2, k), standard error of the measurements (SEMeas) and MDC. Results: Results revealed a good to excellent relative reliability for static QST (ICC ≥ 0.73). For TS, a poor to moderate relative reliability depending on the calculation methods (ICC = 0.25 ≤ ICC ≤ 0.59), and a poor relative reliability for CPM (ICC = 0.16 ≤ ICC ≤ 0.37), both when measured with mechanical stimulation (PPT) and thermal stimulation (HPS). Absolute reliability varied from 0.73 to 7.74 for static QST, 11 to 22 points for TS and corresponded to 11.42 points and 1.56 points for thermal and mechanical-induced CPM, respectively. MDC analyses revealed that a change of 1.58 to 21.46 point for static QST, 31 to 52 points for TS and 4 to 31 points for CPM is necessary to be interpreted as a real change. Conclusion: Our approach seems well-suited to clinical use. Although our method shows equivalent relative and absolute reliability compared to other protocols, we found that the reliability of endogenous pain modulation mechanisms is vulnerable, probably due to its dynamic nature. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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