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10,494 results on '"Louis, D"'

2. Robust deformable image registration using cycle-consistent implicit representations

Author

van Harten, Louis D., Stoker, Jaap, and Išgum, Ivana

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Recent works in medical image registration have proposed the use of Implicit Neural Representations, demonstrating performance that rivals state-of-the-art learning-based methods. However, these implicit representations need to be optimized for each new image pair, which is a stochastic process that may fail to converge to a global minimum. To improve robustness, we propose a deformable registration method using pairs of cycle-consistent Implicit Neural Representations: each implicit representation is linked to a second implicit representation that estimates the opposite transformation, causing each network to act as a regularizer for its paired opposite. During inference, we generate multiple deformation estimates by numerically inverting the paired backward transformation and evaluating the consensus of the optimized pair. This consensus improves registration accuracy over using a single representation and results in a robust uncertainty metric that can be used for automatic quality control. We evaluate our method with a 4D lung CT dataset. The proposed cycle-consistent optimization method reduces the optimization failure rate from 2.4% to 0.0% compared to the current state-of-the-art. The proposed inference method improves landmark accuracy by 4.5% and the proposed uncertainty metric detects all instances where the registration method fails to converge to a correct solution. We verify the generalizability of these results to other data using a centerline propagation task in abdominal 4D MRI, where our method achieves a 46% improvement in propagation consistency compared with single-INR registration and demonstrates a strong correlation between the proposed uncertainty metric and registration accuracy., Comment: 10 pages, 9 figures, accepted in IEEE Transactions on Medical Imaging

Published
2023
Full Text
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3. The LHCb upgrade I

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellan, Abudinén, F., Achard, C., Ackernley, T., Adeva, B., Adinolfi, M., Adlarson, P., Afsharnia, H., Agapopoulou, C., Aidala, C. A., Ajaltouni, Z., Akar, S., Akiba, K., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Aliouche, Z., Cartelle, P. Alvarez, Amalric, R., Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreani, A., Andreianov, A., Andreotti, M., Andreou, D., Andrews, J. E., Anelli, M., Anjam, A., Ao, D., Archilli, F., Arnaud, K., Artamonov, A., Artuso, M., Ashby, J., Aslanides, E., Atzeni, M., Audurier, B., Rocha, D. Ayres, Perea, I. B Bachiller, Bachmann, S., Bachmayer, M., Back, J. J., Bailly-reyre, A., Rodriguez, P. Baladron, Balagura, V., Balbi, G., Baldini, W., Balla, A., Baltazar, M., Band, H., Leite, J. Baptista de Souza, Barbetti, M., Barclay, P., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Basels, J. M., Bassi, G., Baszczyk, M., Lopes, J. C. Batista, Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I. B., Beigbeder-Beau, C., Beiter, A., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Benane, G., Bencivenni, G., Benettoni, M., Ben-Haim, E., Berezhnoy, A., Bernard, F., Bernet, R., Andres, S. Bernet, Berninghoff, D., Bernstein, H. C., Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bezshyiko, Ia., Bezshyyko, O., Bhasin, S., Bhom, J., Bian, L., Bieker, M. S., Biesuz, N. V., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Blago, M. P., Blake, T., Blanc, F., Blank, J. E., Blusk, S., Bobulska, D., Bochin, B., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Bogdanova, G., Boiaryntseva, I., Boldyrev, A., Bolognani, C. S., Bolzonella, R., Bondar, N., Booth, M. J., Borgato, F., Borghi, S., Borsato, M., Borsuk, J. T., Boterenbrood, H., Bouchiba, S. A., Bowcock, T. J. V., Boyaryntsev, A., Boyer, A., Bozzi, C., Bradley, M. J., Braun, S., Rodriguez, A. Brea, Bregliozzi, G., Bridges, K., Briere, M. M. J., Brock, M., Brodski, M., Brodzicka, J., Gonzalo, A. Brossa, Brown, C., Brown, J., Brummitt, A. J., Brundu, D., Brunetti, L., Buda, L., Buonaura, A., Buonincontri, L., Burke, A. T., Burmistrov, L., Burr, C., Bursche, A., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cachemiche, J. P., Cadeddu, S., Cai, H., Caillet, A., Calabrese, R., Calefice, L., Calegari, D., Cali, S., Calvi, M., Gomez, M. Calvo, Campana, P., Perez, D. H. Campora, Quezada, A. F. Campoverde, Canfer, S., Capelli, S., Capriotti, L., Carassiti, V., Carbone, A., Cardinale, R., Cardini, A., Carletti, M., Carniti, P., Carroll, J., Carus, L., Vidal, A. Casais, Caspary, R., Casse, G., Cattaneo, M., Cavallero, G., Cavallini, V., Ceelie, L., Celani, S., Cerasoli, J., Cervenkov, D., Cesare, S., Chadaj, B., Chadwick, A. J., Chahrour, I., Chanal, H., Chapman, M. 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De Freitas Carneiro, De Lucia, E., De Miranda, J. M., de Oliveira, R., De Paula, L., De Roo, K., De Serio, M., De Simone, D., De Simone, P., De Vellis, F., de Vries, J. A., De Wit, E., Dean, C. T., Debernardis, F., Decamp, D., Deckenhoff, M., Dedu, V., Del Buono, L., Delaney, B., Dembinski, H. -P., Denis, C., Denysenko, V., Deschamps, O., Dettori, F., Dey, B., Di Bari, D., Di Nezza, P., Diachkov, I., Didenko, S., Maronas, L. Dieste, Dijkstra, H., Ding, S., Dobishuk, V., Doets, M., Doherty, F., Dolmatov, A., Domke, M., Dong, C., Donohoe, A. M., Dordei, F., Dorosz, P., Reis, A. C. dos, Douglas, L., Downes, A. G., Duarte, O., Duda, P., Dudek, M. W., Dufour, L., Duk, V., Dumps, R., Durante, P., Duras, M. M., Durham, J. M., Dutta, D., Duval, P. Y., Dziewiecki, M., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Orro, C. Eirea, Eisenhardt, S., Ejopu, E., Ekelhof, R., Ek-In, S., Eklund, L., Elashri, M. E, Ellbracht, J., Elvin, A., Ely, S., Ene, A., Epple, E., Escher, S., Eschle, J., Esen, S., Evans, T., Fabiano, F., Falcao, L. N., Fan, Y., Fang, B., Fantini, L., Faria, M., Farry, S., Fazzini, D., Felkowski, L. F, Feo, M., Declara, P. Fernandez, Gomez, M. Fernandez, Fernez, A. D., Ferrari, F., Ferreira, R., Lopes, L. Ferreira, Rodrigues, F. Ferreira, Sole, S. Ferreres, Ferrillo, M., Ferro-Luzzi, M., Filippov, S., Fini, R. A., Fiorini, M., Firlej, M., Fischer, K. M., Fitzgerald, D. S., Fitzpatrick, C., Fiutowski, T., Fleuret, F., Flores, L., Fontana, M., Fontanelli, F., Forty, R., Foulds-Holt, D., Fournier, C., Lima, V. Franco, Sevilla, M. Franco, Frank, M., Franzoso, E., Frau, G., Freestone, J., Frei, C., Frei, R., Frelier, J., Friday, D. A., Frontini, L. F, Fu, J., Fuehring, Q., Fulghesu, T., Fuzipeg, C., Gabriel, E., Galati, G., Galati, M. D., Galka, M., Torreira, A. Gallas, Galli, D., Gallorini, S., Gambetta, S., Gan, Y., Gandelman, M., Gandini, P., Gao, R., Gao, Y., Garau, M., Martin, L. M. Garcia, Moreno, P. Garcia, Pardiñas, J. García, Plana, B. Garcia, Rosales, F. A. Garcia, Garrido, L., Garroum, N., Garsed, P. J., Gascon, D., Gaspar, C., Gasq, C., Gatta, M., Gavardi, L., Gebolis, P. M., Geertsema, R. E., Gerick, D., Gerken, L. L., Germann, D., Gersabeck, E., Gersabeck, M., Gershon, T., Getz, S. A., Giambastiani, L., Gibson, V., Giemza, H. K., Gilman, A. L., Giovannetti, M., Gioventù, A., Girard, O. G., Gironell, P. Gironella, Giugliano, C., Giza, M. A., Gizdov, K., Gkougkousis, E. L., Gligorov, V. V., Göbel, C., Golinka-Bezshyyko, L., Golobardes, E., Golubkov, D., Golutvin, A., Gomes, A., Fernandez, S. Gomez, Abrantes, F. Goncalves, Goncerz, M., Gong, G., Gorelov, I. V., Gotti, C., Grabowski, J. P., Grammatico, T., Cardoso, L. A. Granado, Grant, F., Graugés, E., Graverini, E., Graziani, G., Grecu, A. T., Greeven, L. M., Greim, R., Grieser, N. A., Grillo, L., Gromov, S., Gromov, V., Grub, N., Cazon, B. R. Gruberg, Grynyov, B., Gu, C., Guarise, M., Guerin, S., Guittiere, M., Günther, P. A., Gushchin, E., Guth, A., Guz, Y., Gys, T., Hachon, F., Hadavizadeh, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haimberger, J., Haines, S. C., Halewood-leagas, T., Halvorsen, M. M., Hamilton, P. M., Hammerich, J., Hamrat, S., Han, Q., Han, X., Hansen, E. B., Hansmann-Menzemer, S., Hao, L., Harnew, N., Harrison, T., Hasse, C., Hatch, M., He, J., Heijhoff, K., Hemmer, F. H, Henderson, C., Henderson, R. D. L., Hennequin, A. M., Hennessy, K., Henry, L., Herd, J., Herold, T., Heuel, J., Hicheur, A., Hill, D., Hilton, M., Hoft, G. T., Hollitt, S. E., Hopchev, P. H., Hornberger, O., Horswill, J., Hou, R., Hou, Y., Hu, J., Hu, W., Hu, X., Huang, W., Huang, X., Hulsbergen, W., Hummel, S., Hunter, R. J., Hushchyn, M., Hutanu, O. E., Hutchcroft, D., Hynds, D., Ibis, P., Idzik, M., Ilin, D., Ilten, P., Inglessi, A., Iniukhin, A., Insa, C., Ishteev, A., Ivshin, K., Jacobsson, R., Jage, H., Elles, S. J. Jaimes, Jakobsen, S., Jamet, O., Jans, E., Jashal, B. K., Jaspers, M., Jawahery, A., Jevaud, M., Jevtic, V., Jiang, E., Jiang, X., Jiang, Y., John, D., John, M., Johnson, D., Jones, C. R., Jones, T. P., Jost, B., Jurik, N., Juszczak, I., Kandybei, S., Kang, Y., Karacson, M., Kariuki, J. M., Karpenkov, D., Karpinski, W., Karpov, M., Kaufmann, K., Kautz, J. W., Kayzel, F., Keizer, F., Keller, D. M., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Kholodenko, S., Khreich, G., Kirn, T., Kirsebom, V. S., Kitouni, O., Klaver, S., Kleijne, N., Klimaszewski, K., Kmiec, M. R., Kok, H., Koliiev, S., Kolk, L., Kondybayeva, A., Konoplyannikov, A., Kopciewicz, P., Kopecna, R., Koppenburg, P., Korolev, M., Kos, J., Kostiuk, I., Kot, O., Kotriakhova, S., Kozachuk, A., Kozlov, V. S., Kraan, M., Kravchenko, P., Kravchuk, L., Krawczyk, R. D., Kreps, M., Kretzschmar, S., Krokovny, P., Krupa, W., Krzemien, W., Kubat, J., Kubis, S., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kuhlman, A., Kuilman, W. C., Kulikova, E. K, Kuonen, A. K., Kupfer, N., Kupsc, A., Kvaratskheliya, T., Lacarrere, D., Lafferty, G., Lai, A., Lampis, A., Lancierini, D., Gomez, C. Landesa, Lane, J. J., Lane, R., Langenbruch, C., Langer, J., Langstaff, M., Lantwin, O., Latham, T., Lazzari, F., Lazzaroni, M., Dortz, O. Le, Gac, R. Le, Lee, S. H., Lefèvre, R., Leflat, A., Legotin, S., Lemaitre, F., Lenisa, P., Leroy, O., Lesiak, T., Leverington, B., Li, A., Li, H., Li, K., Li, P., Li, P. -R., Li, S., Li, T., Li, Y., Li, Z., Liang, X., Lieunard, B., Lin, C., Lin, T., Lindner, R., Lisovskyi, V., Litvinov, R., Liu, G., Liu, H., Liu, Q., Liu, S., Salvia, A. Lobo, Loi, A., Lollini, R., Castro, J. Lomba, Longstaff, I., Lopes, J. H., Huertas, A. Lopez, Soliño, S. López, Louis, D., Lovell, G. H., Loveridge, P., Lowe, A. D., Lu, Y., Lucarelli, C., Lucchesi, D., Luchuk, S., Martinez, M. Lucio, Lukashenko, V., Lukianov, A., Luo, H., Luo, Y., Lupato, A., Luppi, E., Lupton, O., Lusiani, A., Lutz, L. F., Lynch, K., Lyu, X. -R., Ma, R., Maccolini, S., Machefert, F., Maciuc, F., Mackay, I., Macko, V., Mackowiak, P., Maddrell-Mander, S., Mohan, L. R. Madhan, Maevskiy, A., Magne, M., Maisuzenko, D., Majewski, M. W., Malaguti, R., Malczewski, J. J., Malde, S., Malecki, B., Malinin, A., Malkinski, K., Maltsev, T., Manca, G., Mancinelli, G., Mancuso, C., Escalero, R. Manera, Manuzzi, D., Manzari, C. A., Marangotto, D., Marchand, J. F., Marconi, U., Mariani, S., Benito, C. Marin, Marks, J., Marshall, A. M., Marshall, P. J., Martelli, G., Martellotti, G., Martinazzoli, L., Martinelli, M., Santos, D. Martinez, Vidal, F. Martinez, Masic, B., Massafferri, A., Materok, M., Matev, R., Mathad, A., Mathe, Z., Matiunin, V., Matteuzzi, C., Mattioli, K. R., Mauri, A., Maurice, E., Mauricio, J., de Cos, J. Mazorra, Mazurek, M., McCann, M., Mcconnell, L., McGrath, T. H., McHugh, N. T., McNab, A., McNulty, R., Mead, J. V., Meadows, B., Meier, G., Meier-villardita, L., Melnychuk, D., Meloni, S., Merk, M., Merli, A., Meunier, J. L., Garcia, L. Meyer, Miao, D., Mikhasenko, M., Milanes, D. A., Millard, E., Miller, G., Milovanovic, M., Minard, M. -N., Minotti, A., Minutoli, S., Miralles, T., Mitchell, S. E., Mitreska, B., Mittelstaedt, T., Mitzel, D. S., Mödden, A., Modenese, L., Mogini, A., Mohammed, R. A., Moise, R. D., Mokhnenko, S., Mombächer, T., Monk, M., Monroy, I. A., Monteil, S., Monti, M., Morandin, M., Morello, G., Morello, M. J., Morgenthaler, M. P., Moron, J., Morris, A. B., Morris, A. G., Mountain, R., Mu, H., Muhammad, E., Muheim, F., Mulder, M., Muley, S., Müller, D., Müller, K., Munneke, B., Murphy, C. H., Murray, D., Murta, R., Muzzetto, P., Naik, P., Naik, S. A., Nakada, T., Nandakumar, R., Nanut, T., Nasteva, I., Nazarov, E., Needham, M., Neri, I., Neri, N., Neubert, S., Neufeld, N., Neustroev, P., Newcombe, R., Trung, T. Nguyen, Nicolini, J., Nicotra, D., Niel, E. M., Nieswand, S., Nikitin, N., Nolte, N. S., Normand, C., Fernandez, J. Novoa, Nowak, G. N, Nunez, C., O'Bannon, T., Oblakowska-Mucha, A., Obraztsov, V., O'Dell, J., Oeser, T., Okamura, S., Oldeman, R., Oliva, F., Olive, P., Onderwater, C. J. G., O'Neil, R. H., Orlov, V., Goicochea, J. M. Otalora, Ovsiannikova, T., Owen, P., Oyanguren, A., Ozcelik, O., Padeken, K. O., Pagare, B., Pais, P. R., Pajero, T., Palano, A., Palutan, M., Pan, Y., Panshin, G., Paoletti, E., Paolucci, L., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Pappenheimer, C., Parker, W., Parkes, C., Pasquali, L., Passalacqua, B., Passaleva, G., Pastore, A., Patel, M., Patrignani, C., Pavlenko, D., Pawley, C. J., Pearce, A., Regales, M. D. P. Peco, Pellegrino, A., Peltier, F., Altarelli, M. Pepe, Perazzini, S., Pereima, D., Castro, A. Pereiro, Perret, P., Perro, A., Perry, M., Pessina, G., Petridis, K., Petrolini, A., Petrucci, S., Petruzzo, M., Pham, H., Philippov, A., Piandani, R., Pica, L., Olloqui, E. Picatoste, Piccini, M., Piedigrossi, D., Pietrzyk, B., Pietrzyk, G., Pili, M., Pillet, N., Pilorz, E. M., Pinci, D., Pisani, F., Pizzichemi, M., Placinta, V., Plews, J., Casasus, M. Plo, Polci, F., Lener, M. Poli, Poluektov, A., Polukhina, N., Polyakov, I., Polyakov, V., Polycarpo, E., Pomery, G. J., Ponce, S., Pons, X., Poplawski, K., Popov, D., Poslavskii, S., Prasanth, K., Pratt, D., Promberger, L., Prouve, C., Pugatch, V., Puill, V., Punzi, G., Qi, H. R., Qian, W., Qin, N., Qu, S., Quagliani, R., Raab, N. V., Rachwal, B., Rademacker, J. H., Rajagopalan, R., Rama, M., Ramaherison, J. J., Pernas, M. Ramos, Rangel, M. S., Ratnikov, F., Raven, G., De Miguel, M. Rebollo, Redi, F., Reich, J., Reiss, F., Alepuz, C. Remon, Ren, Z., Resmi, P. K., Rethore, F., Reynet, D., Ribatti, R., Ricci, A. M., Ricciardi, S., Richards, D. S., Richardson, K., Richardson-Slipper, M., Riedinger, J., Rinnert, K., Robbe, P., Robertson, G., Rochet, J., Rodrigues, A. B., Rodrigues, E., Fernandez, E. Rodriguez, Lopez, J. A. Rodriguez, Perez, P. Rodriguez, Rodriguez, E. Rodriguez, Roeland, E., Rolf, D. L., Rollings, A., Roloff, P., Romanovskiy, V., Lamas, M. Romero, Vidal, A. Romero, Rosier, P., Roth, J. D., Rotondo, M., Rovekamp, J., Roy, L., Rudnyckyj, F., Rudolph, M. S., Ruf, T., Fernandez, R. A. Ruiz, Vidal, J. Ruiz, Ryzhikov, A., Ryzka, J., Silva, J. J. Saborido, Sagidova, N., Sahoo, N., Saitta, B., Salomoni, M., Gras, C. Sanchez, Sanders, F., Sanderswood, I., Santacesaria, R., Rios, C. Santamarina, Santimaria, M., Santovetti, E., Saputi, A., Saranin, D., Sarpis, G., Sarpis, M., Sarti, A., Satriano, C., Satta, A., Saur, M., Saussac, A., Savrina, D., Sazak, H., Sborzacchi, F., Smead, L. G. Scantlebury, Scarabotto, A., Schael, S., Scherl, S., Schiller, M., Schimmel, A., Schindler, H., Schipper, J. D., Schmeitz, R., Schmelling, M., Schmidt, B., Schmitt, S., Schneider, O., Schneider, T., Schopper, A., Schubiger, M., Schulte, S., Schune, M. H., Schwemmer, R., Sciascia, B., Sciuccati, A., Sellam, S., Semennikov, A., Soares, M. Senghi, Sergi, A., Serra, N., Sestak, J., Sestini, L., Seuthe, A., Seyfert, P., Shang, Y., Shangase, D. M., Shapkin, M., Shchemerov, I., Shchutska, L., Shears, T., Shekhtman, L., Shen, Z., Sheng, S., Sherman, M. s, Shevchenko, V., Shi, B., Shields, E. B., Shimizu, Y., Shmanin, E., Shorkin, R., Shupperd, J. D., Siddi, B. G., Siebig, S., Sigmund, D., Sigurdsson, S., Coutinho, R. Silva, Simi, G., Simone, S., Singla, M., Skidmore, N., Skuza, R., Skwarnicki, T., Slater, M. W., Slattery, K., Slazyk, I., Smallwood, J. C., Smeaton, J. G., Smith, E., Smith, K., Smith, M., Smith, N. A., Snoch, A., Lavra, L. Soares, Socha, J-L., Sokoloff, M. D., Soler, F. J. P., Solomin, A., Solovev, A., Solovyev, I., Song, R., De Almeida, F. L. Souza, De Paula, B. Souza, Spaan, B., Norella, E. Spadaro, Spedicato, E., Spiridenkov, E., Spradlin, P., Squerzanti, S., Sriskaran, V., Stagni, F., Stahl, M., Stahl, S., Stanislaus, S., Steffens, E., Stein, E. N., Steinkamp, O., Stenyakin, O., Stevens, H., Stone, S., Stramaglia, M. E., Strekalina, D., Su, Y. S, Suljik, F., Sun, J., Sun, L., Sun, Y., Svihra, P., Swallow, P. N., Swientek, K., Swientek, S., Szabelski, A., Szumlak, T., Szymanski, M., Tagliente, G, Tan, Y., Taneja, S., Tat, M. D., Quere, M. Taurigna, Terentev, A., Terront, D. F., Teubert, F., Thomas, E., Thompson, D. J. D., Thomson, K. A., Tilquin, H., Tisserand, V., T'Jampens, S., Tobin, M., Tomassetti, L., Tonani, G., Tong, X., Topp-Joergensen, S., Machado, D. Torres, Tou, D. Y., Trilov, S. M., Trippl, C., Tuci, G., Tuning, N., Ukleja, A., Unverzagt, D. J., Usachov, A., Ustyuzhanin, A., Uwer, U., Vagner, A., Vagnoni, V., Valassi, A., Valat, S., Valenti, G., Canudas, N. Valls, van Beuzekom, M., Van De Kraats, P. W., van der Heijden, B., Van Dijk, M., van Dongen, J., Van Hecke, H., van Herwijnen, E., Van Hulse, C. B., Van Nieuwland, L., van Overbeek, M., Van Stenis, M., van Veghel, M., Vandaele, R., Gomez, R. Vazquez, Regueiro, P. Vazquez, Sierra, C. Vázquez, Vecchi, S., Veldt, L., Velthuis, J. J., Veltri, M., Venkateswaran, A., Verkooijnen, H., Veronesi, M., Vesterinen, M., Barbosa, J. V. Viana, Vieira, D., Diaz, M. Vieites, Viel, K. J., Vilasis-Cardona, X., Figueras, E. Vilella, Villa, A., Vincent, P., Vink, W., Vitkovskiy, A., Volkov, V., Volle, F. C., Bruch, D. vom, Voneki, B., Vorbach, O., Vorobyev, A., Vorobyev, V., Voropaev, N., Vos, K., Vouters, G., Vrahas, C., Walet, W., Walsh, J., Walton, E. J., Wan, G., Wang, C., Wang, G., Wang, J., Wang, M., Wang, R., Wang, X., Wang, Y., Wang, Z., Ward, J. A., Warda, K., Watson, N. K., Websdale, D., Webster, J., Wei, Y., Westhenry, B. D. C., White, D. J., Whitehead, M., Wieczorek, D., Wiederhold, A. R., Wiedner, D., Wilkinson, G., Wilkinson, M. K., Williams, I., Williams, M., Williams, M. R. J., Williams, R., Wilson, F. F., Wimberley, J., Windelband, B., Wislicki, W., Witek, M., Witola, L., Wlochal, M., Wong, C. P., Wormald, M., Wormser, G., Wotton, S. A., Wraight, K., Wu, H., Wu, J., Wyllie, K., Xiang, Z., Xie, Y., Xu, A., Xu, J., Xu, L., Xu, M., Xu, Q., Xu, Z., Yang, D., Yang, S., Yang, X., Yang, Y., Yang, Z., Yeomans, L. E., Yeroshenko, V., Yeung, H., Yin, H., Yu, J., Yuan, X., Zaffaroni, E., Zavertyaev, M., Zdybal, M., Zenaiev, O., Zeng, M., Zhang, C., Zhang, D., Zhang, L., Zhang, S., Zhang, Y., Zhao, Y., Zharkova, A., Zhelezov, A., Zheng, Y., Zhou, T., Zhou, X., Zhou, Y., Zhovkovska, V., Zhu, X., Zhu, Z., Zhukov, V., Zivkovic, V., Zou, Q., Zucchelli, S., Zuliani, D., Zunica, G., and Zvyagintsev, S.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software., Comment: All figures and tables, along with any supplementary material and additional information, are available at http://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-DP-2022-002.html (LHCb public pages)

Published
2023

4. Science opportunities with solar sailing smallsats

Author

Turyshev, Slava G., Garber, Darren, Friedman, Louis D., Hein, Andreas M., Barnes, Nathan, Batygin, Konstantin, Brin, G. David, Brown, Michael E., Cronin, Leroy, Davoyan, Artur, Dubill, Amber, Eubanks, T. Marshall, Gibson, Sarah, Hassler, Donald M., Izenberg, Noam R., Kervella, Pierre, Mauskopf, Philip D., Murphy, Neil, Nutter, Andrew, Porco, Carolyn, Riccobono, Dario, Schalkwyk, James, Stevenson, Kevin B., Sykes, Mark V., Sultana, Mahmooda, Toth, Viktor T., Velli, Marco, and Worden, S. Pete

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, General Relativity and Quantum Cosmology, Physics - Space Physics
Abstract

Recently, we witnessed how the synergy of small satellite technology and solar sailing propulsion enables new missions. Together, small satellites with lightweight instruments and solar sails offer affordable access to deep regions of the solar system, also making it possible to realize hard-to-reach trajectories that are not constrained to the ecliptic plane. Combining these two technologies can drastically reduce travel times within the solar system, while delivering robust science. With solar sailing propulsion capable of reaching the velocities of ~5-10 AU/yr, missions using a rideshare launch may reach the Jovian system in two years, Saturn in three. The same technologies could allow reaching solar polar orbits in less than two years. Fast, cost-effective, and maneuverable sailcraft that may travel outside the ecliptic plane open new opportunities for affordable solar system exploration, with great promise for heliophysics, planetary science, and astrophysics. Such missions could be modularized to reach different destinations with different sets of instruments. Benefiting from this progress, we present the "Sundiver" concept, offering novel possibilities for the science community. We discuss some of the key technologies, the current design of the Sundiver sailcraft vehicle and innovative instruments, along with unique science opportunities that these technologies enable, especially as this exploration paradigm evolves. We formulate policy recommendations to allow national space agencies, industry, and other stakeholders to establish a strong scientific, programmatic, and commercial focus, enrich and deepen the space enterprise and broaden its advocacy base by including the Sundiver paradigm as a part of broader space exploration efforts., Comment: 35 pages, 12 figures, 3 tables

Published
2023
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8. A fast response mission to rendezvous with an interstellar object

Author

Garber, Darren, Friedman, Louis D, Davoyan, Artur, Turyshev, Slava G, Melamed, Nahum, McVey, John, and Sheerin, Todd F

Subjects
Solar sails, Interstellar objects, Small spacecraft, Mission design, Astronomical and Space Sciences, Astronomy & Astrophysics
Abstract

A solar sail propelled small satellite mission concept to intercept and potentially rendezvous with newly discovered transient interstellar objects (ISOs) is described. The mission concept derives from the proposal for a technology demonstration mission for exiting the solar system at high velocity, eventually to reach the focal region of the solar gravitational lens. The ISO mission concept is to fly a solar sail toward a holding orbit around the Sun and when the ISO orbit is confirmed, target the sailcraft to reach an escape velocity of over 6 AU/year. This would permit rapid response to a new ISO discovery and an intercept within 10 AU from the Sun. Two new proven interplanetary technologies are utilized to enable such a mission: i) interplanetary smallsats, such as those demonstrated by the MarCO mission, and ii) solar sails, such as demonstrated by LightSail and IKAROS missions and developed for NEA Scout and Solar Cruiser missions. Current technology work suggests that already within this decade such a mission could fly and reach an ISO moving through the solar system. It might enable the first encounter with an ISO to allow for imaging and spectroscopy, measurements of size and mass, potentially giving a unique information about the object’s origin and composition. A similar approach may be used to allow for a sample return.

Published
2022

9. A Mission to Nature's Telescope for High-Resolution Imaging of an Exoplanet

Author

Friedman, Louis D., Garber, Darren, Turyshev, Slava G., Helvajian, Henry, Heinshiemer, Thomas, McVey, John, and Davoyan, Artur R.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, General Relativity and Quantum Cosmology
Abstract

The solar gravitational lens (SGL) provides a factor of $10^{11}$ amplification for viewing distant point sources beyond our solar system. As such, it may be used for resolved imaging of extended sources, such as exoplanets, not possible otherwise. To use the SGL, a spacecraft carrying a modest telescope and a coronagraph must reach the SGLs focal region, that begins at $\sim$550 astronomical units (AU) from the Sun and is oriented outward along the line connecting the distant object and the Sun. No spacecraft has ever reached even a half of that distance; and to do so within a reasonable mission lifetime (e.g., less than 25 years) and affordable cost requires a new type of mission design, using solar sails and microsats ($<100$~kg). The payoff is high -- using the SGL is the only practical way we can ever get a high-resolution, multi-pixel image of an Earth-like exoplanet, one that we identify as potentially habitable. This paper describes a novel mission design starting with a rideshare launch from the Earth, spiraling in toward the Sun, and then flying around it to achieve solar system exit speeds of over $20$ AU/year. A new sailcraft design is used to make possible high area to mass ratio for the sailcraft. The mission design enables other fast solar system missions, starting with a proposed very low cost technology demonstration mission (TDM) to prove the functionality and operation of the microsat-solar sail design and then, building on the TDM, missions to explore distant regions of the solar system, and those to study Kuiper Belt objects (KBOs) and the recently discovered interstellar objects (ISOs) are also possible., Comment: 18 pages, 10 figures

Published
2021
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13. Emulsion templated composites: Porous nerve guidance conduits for peripheral nerve regeneration

Author

Louis D. V. Johnson, Mina Aleemardani, Simon Atkins, Fiona M. Boissonade, and Frederik Claeyssens

Subjects
Nerve guidance conduit, Porous, Composite, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Peripheral nerve regeneration fails following more severe injuries where the gap between nerve stumps is too large. Nerve guidance conduits (NGCs) can be implanted to connect the nerve stumps and provide a regenerative microenvironment. This study shows that poly(glycerol sebacate)-methacrylate (PGS-M), a photocurable and biodegradable elastomer, can be used to fabricate porous NGCs. Further, novel developments in emulsion templating techniques are used to generate composite structures and their mechanical properties are investigated. The most appropriate composite for nerve tissue repair had a compressive and tensile Young’s modulus of 0.168 MPa and 0.694 MPa respectively, much closer to that of native nerve tissue than previously used polymers. SEM images revealed high porosity/interconnectivity of NGCs, important for the diffusion of nutrients to further aid nerve regeneration. FITC-Dextran (150 kDa) effectively diffused through conduit walls. Histological analysis demonstrated the small pore size successfully prevented infiltration of fibroblasts. In vitro studies indicated that the NGCs were cytocompatible. Ex vivo analysis showed that neurons of embryonic chick dorsal root ganglia grew on the surface of the conduits, and Schwann cells migrated effectively along the lumen. This study demonstrates a novel way of fabricating porous scaffolds and demonstrates their potential for the treatment of PNI.

Published
2024
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14. A Fast Response Mission to Rendezvous with an Interstellar Object

Author

Garber, Darren, Friedman, Louis D., Davoyan, Artur R., Turyshev, Slava G., Melamed, Nahum, McVey, John, and Sheerin, Todd F.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A solar sail propelled small satellite mission concept to intercept and potentially rendezvous with newly discovered transient interstellar objects (ISOs) is described. The mission concept derives from the proposal for a technology demonstration mission for exiting the solar system at high velocity, eventually to reach the focal region of the solar gravitational lens. The ISO mission concept is to fly a solar sail toward a holding orbit around the Sun and when the ISO orbit is confirmed, target the sailcraft to reach an escape velocity of over 6 AU/year. This would permit rapid response to a new ISO discovery and an intercept within 10 AU from the Sun. Two new proven interplanetary technologies are utilized to enable such a mission: i) interplanetary smallsats, such as those demonstrated by the MarCO mission, and ii) solar sails, such as demonstrated by LightSail and IKAROS missions and developed for NEA Scout and Solar Cruiser missions. Current technology work suggests that already within this decade such a mission could fly and reach an ISO moving through the solar system. It might enable the first encounter with an ISO to allow for imaging and spectroscopy, measurements of size and mass, potentially giving a unique information about the object's origin and composition. A similar approach may be used to allow for a sample return., Comment: 17 pages, 9 figures

Published
2021
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17. 3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging

Author

Soumya Ghose, Yingnan Ju, Elizabeth McDonough, Jonhan Ho, Arivarasan Karunamurthy, Chrystal Chadwick, Sanghee Cho, Rachel Rose, Alex Corwin, Christine Surrette, Jessica Martinez, Eric Williams, Anup Sood, Yousef Al-Kofahi, Louis D. Falo, Katy Börner, and Fiona Ginty

Subjects
Biology (General), QH301-705.5
Abstract

Abstract Mapping the human body at single cell resolution in three dimensions (3D) is important for understanding cellular interactions in context of tissue and organ organization. 2D spatial cell analysis in a single tissue section may be limited by cell numbers and histology. Here we show a workflow for 3D reconstruction of multiplexed sequential tissue sections: MATRICS-A (Multiplexed Image Three-D Reconstruction and Integrated Cell Spatial - Analysis). We demonstrate MATRICS-A in 26 serial sections of fixed skin (stained with 18 biomarkers) from 12 donors aged between 32–72 years. Comparing the 3D reconstructed cellular data with the 2D data, we show significantly shorter distances between immune cells and vascular endothelial cells (56 µm in 3D vs 108 µm in 2D). We also show 10–70% more T cells (total) within 30 µm of a neighboring T helper cell in 3D vs 2D. Distances of p53, DDB2 and Ki67 positive cells to the skin surface were consistent across all ages/sun exposure and largely localized to the lower stratum basale layer of the epidermis. MATRICS-A provides a framework for analysis of 3D spatial cell relationships in healthy and aging organs and could be further extended to diseased organs.

Published
2023
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20. Enabling High-Resolution Imaging and Spectroscopy of an Exoplanet by Use of the Solar Gravity Lens

Author

Shao, Michael, primary, Alkalai, Leon, primary, Shen, Janice, primary, Swain, Mark R., primary, Toth, Viktor T., primary, Helvajian, Henry, primary, Heinsheimer, Tom, primary, McVey, John, primary, Garber, Darren, primary, Davoyan, Artur, primary, Males, Jared R., primary, Turyshev, Slava G., primary, Zhou, Hanying, primary, Friedman, Louis D., primary, Mawet, Dmitri, primary, Janson, Siegfried W., primary, Leszczynski, Zigmond, primary, and Redfield, Seth, primary

Published
2023
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21. Exploring the Outer Solar System with Solar Sailing Smallsats on Fast-Transit Trajectories and In-Flight Autonomous Assembly of Advanced Science Payloads

Author

Turyshev, Slava G., Helvajian, Henry, Friedman, Louis D., Heinsheimer, Tom, Garber, Darren, Davoyan, Artur, and Toth, Viktor T.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Physics - Instrumentation and Detectors
Abstract

We discuss the in-flight autonomous assembly as the means to build advanced planetary science payloads to explore the outer regions of the solar system. These payloads are robotically constructed from modular parts delivered by a group of smallsats (< 20 kg) which are placed on fast solar system transfer trajectories while being accelerated by solar sail propulsion to velocities of ~10 AU/yr. This concept provides the planetary science community with inexpensive, frequent access to distant regions of the solar system with flexible, reconfigurable instruments and systems that are assembled in flight. It permits faster revisit times, rapid replenishment and technology insertions, longer mission capability with lower costs. It also increases the science capabilities of smallsats via the use of modular, redundant architectures and allows for proliferation of sensing instrumentation throughout the solar system., Comment: A White Paper to the National Academy of Sciences Planetary Science and Astrobiology Decadal Survey 2023-2032. 7 pages

Published
2020
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22. Direct Multipixel Imaging and Spectroscopy of an Exoplanet with a Solar Gravity Lens Mission

Author

Turyshev, Slava G., Shao, Michael, Toth, Viktor T., Friedman, Louis D., Alkalai, Leon, Mawet, Dmitri, Shen, Janice, Swain, Mark R., Zhou, Hanying, Helvajian, Henry, Heinsheimer, Tom, Janson, Siegfried, Leszczynski, Zigmond, McVey, John, Garber, Darren, Davoyan, Artur, Redfield, Seth, and Males, Jared R.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, General Relativity and Quantum Cosmology, Physics - Optics
Abstract

We examined the solar gravitational lens (SGL) as the means to produce direct high-resolution, multipixel images of exoplanets. The properties of the SGL are remarkable: it offers maximum light amplification of ~1e11 and angular resolution of ~1e-10 arcsec. A probe with a 1-m telescope in the SGL focal region can image an exoplanet at 30 pc with 10-kilometer resolution on its surface, sufficient to observe seasonal changes, oceans, continents, surface topography. We reached and exceeded all objectives set for our study: We developed a new wave-optical approach to study the imaging of exoplanets while treating them as extended, resolved, faint sources at large but finite distances. We properly accounted for the solar corona brightness. We developed deconvolution algorithms and demonstrated the feasibility of high-quality image reconstruction under realistic conditions. We have proven that multipixel imaging and spectroscopy of exoplanets with the SGL are feasible. We have developed a new mission concept that delivers an array of optical telescopes to the SGL focal region relying on three innovations: i) a new way to enable direct exoplanet imaging, ii) use of smallsats solar sails fast transit through the solar system and beyond, iii) an open architecture to take advantage of swarm technology. This approach enables entirely new missions, providing a great leap in capabilities for NASA and the greater aerospace community. Our results are encouraging as they lead to a realistic design for a mission that will be able to make direct resolved images of exoplanets in our stellar neighborhood. It could allow exploration of exoplanets relying on the SGL capabilities decades, if not centuries, earlier than possible with other extant technologies. The architecture and mission concepts for a mission to the strong interference region of the SGL are promising and should be explored further., Comment: Final Report for the NASA's Innovative Advanced Concepts (NIAC) Phase II proposal. 91 pages, 50 figures, 5 tables

Published
2020

23. Automatic Online Quality Control of Synthetic CTs

Author

van Harten, Louis D., Wolterink, Jelmer M., Verhoeff, Joost J. C., and Išgum, Ivana

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Accurate MR-to-CT synthesis is a requirement for MR-only workflows in radiotherapy (RT) treatment planning. In recent years, deep learning-based approaches have shown impressive results in this field. However, to prevent downstream errors in RT treatment planning, it is important that deep learning models are only applied to data for which they are trained and that generated synthetic CT (sCT) images do not contain severe errors. For this, a mechanism for online quality control should be in place. In this work, we use an ensemble of sCT generators and assess their disagreement as a measure of uncertainty of the results. We show that this uncertainty measure can be used for two kinds of online quality control. First, to detect input images that are outside the expected distribution of MR images. Second, to identify sCT images that were generated from suitable MR images but potentially contain errors. Such automatic online quality control for sCT generation is likely to become an integral part of MR-only RT workflows., Comment: SPIE Medical Imaging 2020

Published
2019

24. Exploiting Clinically Available Delineations for CNN-based Segmentation in Radiotherapy Treatment Planning

Author

van Harten, Louis D., Wolterink, Jelmer M., Verhoeff, Joost J. C., and Išgum, Ivana

Subjects
Computer Science - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Statistics - Machine Learning
Abstract

Convolutional neural networks (CNNs) have been widely and successfully used for medical image segmentation. However, CNNs are typically considered to require large numbers of dedicated expert-segmented training volumes, which may be limiting in practice. This work investigates whether clinically obtained segmentations which are readily available in picture archiving and communication systems (PACS) could provide a possible source of data to train a CNN for segmentation of organs-at-risk (OARs) in radiotherapy treatment planning. In such data, delineations of structures deemed irrelevant to the target clinical use may be lacking. To overcome this issue, we use multi-label instead of multi-class segmentation. We empirically assess how many clinical delineations would be sufficient to train a CNN for the segmentation of OARs and find that increasing the training set size beyond a limited number of images leads to sharply diminishing returns. Moreover, we find that by using multi-label segmentation, missing structures in the reference standard do not have a negative effect on overall segmentation accuracy. These results indicate that segmentations obtained in a clinical workflow can be used to train an accurate OAR segmentation model., Comment: SPIE Medical Imaging 2020

Published
2019

27. Violent Raiding, Systematic Slaving, and Sweeping Depopulation? Re-Evaluating the Scythian Impact on Central Europe through the Lens of the Witaszkowo/Vettersfelde Hoard

Author

Louis D. Nebelsick

Subjects
Scythian, treasure, Vettersfelde/Witaszkowo, animal art, raiding, colonization, Arts in general, NX1-820
Abstract

In 1882, the lavishly decorated golden regalia of a steppe nomad warrior prince, which was crafted in the late sixth century BCE in a “bilingual” Scythian–Milesian workshop on the Black Sea coast, was found on the edge of a Lusatian swamp 120 km southeast of Berlin. Its discovery and the ongoing findings of steppe nomad armaments—arrows, battle axes, and swords—in central Europe have led to a lively debate about the nature of Scythian–Indigenous interaction in the Early Iron Age, ranging from benign visions of long-term acculturation to violent scenarios of short-term raiding. In this article, I argue that an analysis of the iconography of the Witaszkowo hoard and new information from excavations at its find spot make it likely that it was sent as a diplomatic gift by Scythian elites to an indigenous leader and deposited by the local community as a votive hoard. An affirmation of the compact chronological range of Scythian artefacts found in the west, growing evidence for the destruction of indigenous strongholds by horse-borne archers, and concurrent evidence for the drastic depopulation of vast landscapes in the second half of the sixth century BCE allow us to envisage the gifting of this hoard as an episode of a fierce and destructive altercation. It is posited that this onslaught was a facet of the western thrust of the Lydian and Persian Empires, and that its extirpative impact was the result of systematic, commercially driven slaving triggered by the concurrent monetisation of the economies of the Black Sea coast. The effects of these raids on Eastern Central Europe’s later prehistoric communities are made manifest by analogies to the disastrous ramifications of the transatlantic slave trade on societies of 16th-to-18th-century West Africa.

Published
2024
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28. A common origin for dynamically associated near-Earth asteroid pairs

Author

Moskovitz, Nicholas, Fatka, Petr, Farnocchia, Davide, Devogele, Maxime, Polishook, David, Thomas, Cristina A., Mommert, Michael, Avner, Louis D., Binzel, Richard P., Burt, Brian, Christensen, Eric, DeMeo, Francesca, Hinkle, Mary, Hora, Joseph L., Magnusson, Mitchell, Matson, Robert, Person, Michael, Skiff, Brian, Thirouin, Audrey, Trilling, David, Wasserman, Lawrence H., and Willman, Mark

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Though pairs of dynamically associated asteroids in the Main Belt have been identified and studied for over a decade, very few pair systems have been identified in the near-Earth asteroid population. We present data and analysis that supports the existence of two genetically related pairs in near-Earth space. The members of the individual systems, 2015 EE7 -- 2015 FP124 and 2017 SN16 -- 2018 RY7, are found to be of the same spectral taxonomic class, and both pairs are interpreted to have volatile-poor compositions. In conjunction with dynamical arguments, this suggests that these two systems formed via YORP spin-up and/or dissociation of a binary precursor. Backwards orbital integrations suggest a separation age of <10 kyr for the pair 2017 SN16 -- 2018 RY7, making these objects amongst the youngest multiple asteroid systems known to date. A unique separation age was not realized for 2015 EE7 -- 2015 FP124 due to large uncertainties associated with these objects' orbits. Determining the ages of such young pairs is of great value for testing models of space weathering and asteroid spin-state evolution. As the NEO catalog continues to grow with current and future discovery surveys, it is expected that more NEO pairs will be found, thus providing an ideal laboratory for studying time dependent evolutionary processes that are relevant to asteroids throughout the Solar System., Comment: 8 figures, 2 tables; Accepted to Icarus

Published
2019
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31. Adherence in children using positive airway pressure therapy: a big-data analysis

Author

Bhattacharjee, Rakesh, Benjafield, Adam V, Armitstead, Jeff, Cistulli, Peter A, Nunez, Carlos M, Pepin, Jean-Louis D, Woehrle, Holger, Yan, Yang, Malhotra, Atul, and group, medXcloud

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Pediatric, Neurosciences, Health Disparities, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Adolescent, Big Data, Child, Child, Preschool, Continuous Positive Airway Pressure, Cross-Sectional Studies, Data Analysis, Female, Humans, Male, Patient Compliance, Retrospective Studies, Sleep Apnea Syndromes, medXcloud group, Health services and systems
Abstract

BackgroundPositive airway pressure (PAP) has become a prominent treatment for children with sleep-disordered breathing. However, there are no large-scale studies to clarify whether PAP is well tolerated in children, and which factors are associated with better adherence to PAP therapy. In this study, we aimed to clarify adherence patterns of PAP therapy in a large paediatric population.MethodsWe did a cross-sectional big-data analysis in children from Oct 1, 2014, to Aug 1, 2018, using existing data derived from PAP devices uploaded nightly in the AirView cloud database. The AirView database is a usage tracking system available to all patients who are assigned PAP therapy, which requires consent from the patient or parent or guardian. All patients older than 4 years and younger than 18 years who used continuous or automated PAP devices were evaluated. Only patients living in the USA and enrolled with a single insurance company were included. If patients were participating in an engagement programme, programme onset must have been within 7 days of therapy onset. Our primary outcome was the proportion of patients who used PAP continuously over 90 days. The primary outcome was assessed in all patients who met the age inclusion criterion and had reliable age data available. Data on missing PAP use were imputed as zero, but data on other metrics were not imputed and excluded from analysis.FindingsWe used data recorded from Oct 1, 2014, to Aug 1, 2018. Of 40 140 children screened, 36 058 (89·8%) were US residents and 20 553 (90·1%) of them met the eligibility criteria and had accessible data (mean age 13·0 years [SD 3·7]). On the basis of 90 days of monitoring data, 12 699 (61·8%) patients continuously used PAP. Factors significantly associated with adherence included age group, residual apnoea-hypopnoea index, use and onset of patient engagement programmes, PAP pressure, and nightly median PAP mask leak, all over the 90-day study period.InterpretationTo our knowledge, our study represents the largest analysis of children using PAP therapy to date. The findings suggest that adherence to PAP therapy is lower than in previous reports from adults. However, numerous actionable factors were associated with improvements in adherence and should be used strategically in clinical decision making to improve PAP adherence in children.FundingResMed.

Published
2020

32. WIRC+Pol: a low-resolution near-infrared spectropolarimeter

Author

Tinyanont, Samaporn, Millar-Blanchaer, Maxwell A., Nilsson, Ricky, Mawet, Dimitri, Knutson, Heather, Kataria, Tiffany, Vasisht, Gautam, Henderson, Charles, Matthews, Keith, Serabyn, Eugene, Milburn, Jennifer W., Hale, David, Smith, Roger, Vissapragada, Shreyas, Santos Jr, Louis D., Kekas, Jason, and Escuti, Michael J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

WIRC+Pol is a newly commissioned low-resolution (R~100), near-infrared (J and H band) spectropolarimetry mode of the Wide-field InfraRed Camera (WIRC) on the 200-inch Hale Telescope at Palomar Observatory. The instrument utilizes a novel polarimeter design based on a quarter-wave plate and a polarization grating (PG), which provides full linear polarization measurements (Stokes I, Q, and U) in one exposure. The PG also has high transmission across the J and H bands. The instrument is situated at the prime focus of an equatorially mounted telescope. As a result, the system only has one reflection in the light path, providing minimal telescope induced polarization. A data reduction pipeline has been developed for WIRC+Pol to produce linear polarization measurements from observations. WIRC+Pol has been on-sky since February 2017. Results from the first year commissioning data show that the instrument has a high dispersion efficiency as expected from the polarization grating. We demonstrate the polarimetric stability of the instrument with RMS variation at 0.2% level over 30 minutes for a bright standard star (J = 8.7). While the spectral extraction is photon noise limited, polarization calibration between sources remain limited by systematics, likely related to gravity dependent pointing effects. We discuss instrumental systematics we have uncovered in the data, their potential causes, along with calibrations that are necessary to eliminate them. We describe a modulator upgrade that will eliminate the slowly varying systematics and provide polarimetric accuracy better than 0.1%., Comment: Published in PASP

Published
2018
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33. IQ

Author

Matzel, Louis D., Sauce, Bruno, Krause, Mark A., Section editor, Vonk, Jennifer, editor, and Shackelford, Todd K., editor

Published
2022
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34. Inductive Reasoning

Author

Sauce, Bruno, Matzel, Louis D., Krause, Mark A., Section editor, Vonk, Jennifer, editor, and Shackelford, Todd K., editor

Published
2022
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39. Compliance after switching from CPAP to bilevel for patients with non-compliant OSA: big data analysis

Author

Benjafield, Adam V, Pepin, Jean-Louis D, Valentine, Kate, Cistulli, Peter A, Woehrle, Holger, Nunez, Carlos M, Armitstead, Jeff, and Malhotra, Atul

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Sleep Research, Lung, Adult, Aged, Continuous Positive Airway Pressure, Data Analysis, Humans, Middle Aged, Patient Compliance, Polysomnography, Retrospective Studies, Sleep Apnea, Obstructive, Telemetry, United States, sleep apnoea, Cardiovascular medicine and haematology, Clinical sciences
Abstract

IntroductionFor patients with obstructive sleep apnoea (OSA) who are initially non-compliant with continuous (automatic) positive airway pressure (CPAP/APAP) therapy, a bilevel PAP (Spont/VAuto) therapy transition pathway is available to improve therapy adherence. The aim of this retrospective study was to compare PAP therapy usage data of patients with non-compliant OSA (ncOSA) on CPAP/APAP who were switched to bilevel PAP.MethodsA PAP telemonitoring database was queried between 1 January 2015 and 31 July 2016 for eligible patients started on CPAP/APAP and non-CMS (United States Center for Medicare and Medicaid Services) compliant and switched to bilevel PAP within 90 days of starting CPAP/APAP therapy. PAP therapy data on all patients were compared before switch (CPAP/APAP) and after switch (VAuto/Spont).ResultsOf the 1496 patients with ncOSA identified, 30.3% used CPAP, 62.3% APAP, and 7.4% both APAP and CPAP before switching to a bilevel mode. 47.8% patients switched to Spont mode and 52.2% to VAuto mode. PAP usage significantly improved by 0.9 h/day (p

Published
2019

40. An Estimate of the Global Prevalence and Burden of Obstructive Sleep Apnoea

Author

Benjafield, Adam, Ayas, Najib T, Eastwood, Peter R, Heinzer, Raphael, Ip, Mary SM, Morrell, Mary J, Nunez, Carlos M, Patel, Sanjay R, Penzel, Thomas, Pépin, Jean-Louis D, Peppard, Paul E, Sinha, Sanjeev, Tufik, Sergio, Valentine, Kate, and Malhotra, Atul

Subjects
Sleep apnoea, Epidemiology
Published
2019

42. A multi-faceted role of dual-state dopamine signaling in working memory, attentional control, and intelligence

Author

Louis D. Matzel and Bruno Sauce

Subjects
dopamine, intelligence, working memory, attention, receptor subtypes, behavioral genetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Genetic evidence strongly suggests that individual differences in intelligence will not be reducible to a single dominant cause. However, some of those variations/changes may be traced to tractable, cohesive mechanisms. One such mechanism may be the balance of dopamine D1 (D1R) and D2 (D2R) receptors, which regulate intrinsic currents and synaptic transmission in frontal cortical regions. Here, we review evidence from human, animal, and computational studies that suggest that this balance (in density, activity state, and/or availability) is critical to the implementation of executive functions such as attention and working memory, both of which are principal contributors to variations in intelligence. D1 receptors dominate neural responding during stable periods of short-term memory maintenance (requiring attentional focus), while D2 receptors play a more specific role during periods of instability such as changing environmental or memory states (requiring attentional disengagement). Here we bridge these observations with known properties of human intelligence. Starting from theories of intelligence that place executive functions (e.g., working memory and attentional control) at its center, we propose that dual-state dopamine signaling might be a causal contributor to at least some of the variation in intelligence across individuals and its change by experiences/training. Although it is unlikely that such a mechanism can account for more than a modest portion of the total variance in intelligence, our proposal is consistent with an array of available evidence and has a high degree of explanatory value. We suggest future directions and specific empirical tests that can further elucidate these relationships.

Published
2023
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46. A microarray patch SARS-CoV-2 vaccine induces sustained antibody responses and polyfunctional cellular immunity

Author

Stephen C. Balmert, Zohreh Gholizadeh Ghozloujeh, Cara Donahue Carey, Li’an H. Williams, Jiying Zhang, Preeti Shahi, Maher Amer, Tina L. Sumpter, Geza Erdos, Emrullah Korkmaz, and Louis D. Falo, Jr.

Subjects
Immunology, Virology, Medical biotechnology, Science
Abstract

Summary: Sustainable global immunization campaigns against COVID-19 and other emerging infectious diseases require effective, broadly deployable vaccines. Here, we report a dissolvable microarray patch (MAP) SARS-CoV-2 vaccine that targets the immunoresponsive skin microenvironment, enabling efficacious needle-free immunization. Multicomponent MAPs delivering both SARS-CoV-2 S1 subunit antigen and the TLR3 agonist Poly(I:C) induce robust antibody and cellular immune responses systemically and in the respiratory mucosa. MAP vaccine-induced antibodies bind S1 and the SARS-CoV-2 receptor-binding domain, efficiently neutralize the virus, and persist at high levels for more than a year. The MAP platform reduces systemic toxicity of the delivered adjuvant and maintains vaccine stability without refrigeration. When applied to human skin, MAP vaccines activate skin-derived migratory antigen-presenting cells, supporting the feasibility of human translation. Ultimately, this shelf-stable MAP vaccine improves immunogenicity and safety compared to traditional intramuscular vaccines and offers an attractive alternative for global immunization efforts against a range of infectious pathogens.

Published
2022
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49. A Chronic Increase in Blood-Brain Barrier Permeability Facilitates Intraneuronal Deposition of Exogenous Bloodborne Amyloid-Beta1–42 Peptide in the Brain and Leads to Alzheimer’s Disease-Relevant Cognitive Changes in a Mouse Model

Author

Acharya, Nimish K., primary, Grossman, Henya C., additional, Clifford, Peter M., additional, Levin, Eli C., additional, Light, Kenneth R., additional, Choi, Hana, additional, Swanson II, Randel L., additional, Kosciuk, Mary C., additional, Venkataraman, Venkat, additional, Libon, David J., additional, Matzel, Louis D., additional, and Nagele, Robert G., additional

Published
2024
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