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248 results on '"Loudig, Olivier"'

1. Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination

Author

Shi, Miao, Han, Weiguo, Loudig, Olivier, Shah, Chirag D., Dobkin, Jay B., Keller, Steven, Sadoughi, Ali, Zhu, Changcheng, Siegel, Robert E., Fernandez, Maria Katherine, DeLaRosa, Lizett, Patel, Dhruv, Desai, Aditi, Siddiqui, Taha, Gombar, Saurabh, Suh, Yousin, Wang, Tao, Hosgood, H. Dean, Pradhan, Kith, Ye, Kenny, and Spivack, Simon D.

Published
2023
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6. Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles

Author

Mitchell, Megan I., primary, Ben-Dov, Iddo Z., additional, Liu, Christina, additional, Wang, Tao, additional, Hazan, Rachel B., additional, Bauer, Thomas L., additional, Zakrzewski, Johannes, additional, Donnelly, Kathryn, additional, Chow, Kar, additional, Ma, Junfeng, additional, and Loudig, Olivier, additional

Published
2024
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13. Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

Author

Weinger, Jason G, Brosnan, Celia F, Loudig, Olivier, Goldberg, Michael F, Macian, Fernando, Arnett, Heather A, Prieto, Anne L, Tsiperson, Vladislav, and Shafit-Zagardo, Bridget

Abstract

Abstract Background Axl, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. To test for this, we studied the susceptibility of Axl-/- mice to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. Methods WT and Axl-/- mice were immunized with myelin oligodendrocyte glycoprotein (MOG)35-55 peptide emulsified in complete Freund's adjuvant and injected with pertussis toxin on day 0 and day 2. Mice were monitored daily for clinical signs of disease and analyzed for pathology during the acute phase of disease. Immunological responses were monitored by flow cytometry, cytokine analysis and proliferation assays. Results Axl-/- mice had a significantly more severe acute phase of EAE than WT mice. Axl-/- mice had more spinal cord lesions with larger inflammatory cuffs, more demyelination, and more axonal damage than WT mice during EAE. Strikingly, lesions in Axl-/- mice had more intense Oil-Red-O staining indicative of inefficient clearance of myelin debris. Fewer activated microglia/macrophages (Iba1+) were found in and/or surrounding lesions in Axl-/- mice relative to WT mice. In contrast, no significant differences were noted in immune cell responses between naïve and sensitized animals. Conclusions These data show that Axl alleviates EAE disease progression and suggests that in EAE Axl functions in the recruitment of microglia/macrophages and in the clearance of debris following demyelination. In addition, these data provide further support that administration of the Axl ligand Gas6 could be therapeutic for immune-mediated demyelinating diseases.

Published
2011

15. SARS-CoV-2 Infection in Unvaccinated High-Risk Pregnant Women in the Bronx, NY, USA Is Associated with Decreased Apgar Scores and Placental Villous Infarcts

Author

Reznik, Sandra E., primary, Vuguin, Patricia M., additional, Cohen, Alexa, additional, Khoury, Rasha, additional, Loudig, Olivier, additional, Balakrishnan, Ridin, additional, Fineberg, Susan A., additional, Hughes, Francine, additional, Harigopal, Malini, additional, and Charron, Maureen J., additional

Published
2023
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17. Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed.

Author

Mitchell, Megan I., Ben‐Dov, Iddo Z., Ye, Kenny, Liu, Christina, Shi, Miao, Sadoughi, Ali, Shah, Chirag, Siddiqui, Taha, Okorozo, Aham, Gutierrez, Martin, Unawane, Rashmi, Biamonte, Lisa, Parikh, Kaushal, Spivack, Simon, and Loudig, Olivier

Subjects
LUNGS, EXTRACELLULAR vesicles, GENE expression, NUCLEOTIDE sequencing, LUNG cancer, MICRORNA
Abstract

Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development of biomarker assays, the detection of lung cancer remains a significant challenge. However, the lung communicates directly with the external environment and releases aerosolized droplets during normal tidal respiration, which can be collected, stored and analzsed as exhaled breath condensate (EBC). A few studies have suggested that EBC contains extracellular vesicles (EVs) whose microRNA (miRNA) cargos may be useful for evaluating different lung conditions, but the cellular origin of these EVs remains unknown. In this study, we used nanoparticle tracking, transmission electron microscopy, Western blot analyses and super resolution nanoimaging (ONi) to detect and validate the identity of exhaled EVs (exh‐EVs). Using our customizable antibody‐purification assay, EV‐CATCHER, we initially determined that exh‐EVs can be selectively enriched from EBC using antibodies against three tetraspanins (CD9, CD63 and CD81). Using ONi we also revealed that some exh‐EVs harbour lung‐specific proteins expressed in bronchiolar Clara cells (Clara Cell Secretory Protein [CCSP]) and Alveolar Type II cells (Surfactant protein C [SFTPC]). When conducting miRNA next generation sequencing (NGS) of airway samples collected at five different anatomic levels (i.e., mouth rinse, mouth wash, bronchial brush, bronchoalveolar lavage [BAL] and EBC) from 18 subjects, we determined that miRNA profiles of exh‐EVs clustered closely to those of BAL EVs but not to those of other airway samples. When comparing the miRNA profiles of EVs purified from matched BAL and EBC samples with our three tetraspanins EV‐CATCHER assay, we captured significant miRNA expression differences associated with smoking, asthma and lung tumor status of our subjects, which were also reproducibly detected in EVs selectively purified with our anti‐CCSP/SFTPC EV‐CATCHER assay from the same samples, but that confirmed their lung tissue origin. Our findings underscore that enriching exh‐EV subpopulations from EBC allows non‐invasive sampling of EVs produced by lung tissues. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The Breast Microbiome in Breast Cancer Risk and Progression: A Narrative Review.

Author

Peters, Brandilyn A., Kelly, Libusha, Tao Wang, Loudig, Olivier, and Rohan, Thomas E.

Abstract

A decade ago, studies in human populations first revealed the existence of a unique microbial community in the breast, a tissue historically viewed as sterile, with microbial origins seeded through the nipple and/or translocation from other body sites. Since then, research efforts have been made to characterize the microbiome in healthy and cancerous breast tissues. The purpose of this review is to summarize the current evidence for the association of the breast microbiome with breast cancer risk and progression. Briefly, while many studies have examined the breast microbiome in patients with breast cancer, and compared it with the microbiome of benign breast disease tissue or normal breast tissue, these studies have varied widely in their sample sizes, methods, and quality of evidence. Thus, while several large and rigorous cross-sectional studies have provided key evidence of an altered microbiome in breast tumors compared with normal adjacent and healthy control tissue, there are few consistent patterns of perturbed microbial taxa. In addition, only one large prospective study has provided evidence of a relationship between the breast tumor microbiota and cancer prognosis. Future research studies featuring large, well-characterized cohorts with prospective follow-up for breast cancer incidence, progression, and response to treatment are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Figure S3 from An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer

Author

Sharif, Ghada M., primary, Campbell, Moray J., primary, Nasir, Apsra, primary, Sengupta, Surojeet, primary, Graham, Garrett T., primary, Kushner, Max H., primary, Kietzman, William B., primary, Schmidt, Marcel O., primary, Pearson, Gray W., primary, Loudig, Olivier, primary, Fineberg, Susan, primary, Wellstein, Anton, primary, and Riegel, Anna T., primary

Published
2023
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21. Supplemental Figure.1 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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23. Supplemental Figure. 5 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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24. Supplemental Figure. 3 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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25. Table S3 from An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer

Author

Sharif, Ghada M., primary, Campbell, Moray J., primary, Nasir, Apsra, primary, Sengupta, Surojeet, primary, Graham, Garrett T., primary, Kushner, Max H., primary, Kietzman, William B., primary, Schmidt, Marcel O., primary, Pearson, Gray W., primary, Loudig, Olivier, primary, Fineberg, Susan, primary, Wellstein, Anton, primary, and Riegel, Anna T., primary

Published
2023
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26. Data from An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer

Author

Sharif, Ghada M., primary, Campbell, Moray J., primary, Nasir, Apsra, primary, Sengupta, Surojeet, primary, Graham, Garrett T., primary, Kushner, Max H., primary, Kietzman, William B., primary, Schmidt, Marcel O., primary, Pearson, Gray W., primary, Loudig, Olivier, primary, Fineberg, Susan, primary, Wellstein, Anton, primary, and Riegel, Anna T., primary

Published
2023
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27. Supplemental methods from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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28. Data from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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31. Supplementary Figure legends from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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32. Supplemental Figure. 2 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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33. Supplemental Figure. 4 from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis

Author

Suyama, Kimita, primary, Yao, Jiahong, primary, Liang, Huizhi, primary, Benard, Outhiriaradjou, primary, Loudig, Olivier D., primary, Amgalan, Dulguun, primary, McKimpson, Wendy M., primary, Phillips, Greg R., primary, Segall, Jeffrey, primary, Wang, Yihong, primary, Fineberg, Susan, primary, Norton, Larry, primary, Kitsis, Richard N., primary, and Hazan, Rachel B., primary

Published
2023
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34. Supplementary Methods from An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer

Author

Sharif, Ghada M., primary, Campbell, Moray J., primary, Nasir, Apsra, primary, Sengupta, Surojeet, primary, Graham, Garrett T., primary, Kushner, Max H., primary, Kietzman, William B., primary, Schmidt, Marcel O., primary, Pearson, Gray W., primary, Loudig, Olivier, primary, Fineberg, Susan, primary, Wellstein, Anton, primary, and Riegel, Anna T., primary

Published
2023
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35. Supplementary Materials and Methods, Figure Legends from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

Author

Kim, Seaho, primary, Yao, Jiahong, primary, Suyama, Kimita, primary, Qian, Xia, primary, Qian, Bin-Zhi, primary, Bandyopadhyay, Sanmay, primary, Loudig, Olivier, primary, De Leon-Rodriguez, Carlos, primary, Zhou, Zhen Ni, primary, Segall, Jeffrey, primary, Macian, Fernando, primary, Norton, Larry, primary, and Hazan, Rachel B., primary

Published
2023
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36. Supplementary Table 1 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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37. Supplementary Figure Legends 1-6 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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38. Supplementary Figure 4 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

Author

Kim, Seaho, primary, Yao, Jiahong, primary, Suyama, Kimita, primary, Qian, Xia, primary, Qian, Bin-Zhi, primary, Bandyopadhyay, Sanmay, primary, Loudig, Olivier, primary, De Leon-Rodriguez, Carlos, primary, Zhou, Zhen Ni, primary, Segall, Jeffrey, primary, Macian, Fernando, primary, Norton, Larry, primary, and Hazan, Rachel B., primary

Published
2023
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39. Supplementary Figure 1 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

Author

Kim, Seaho, primary, Yao, Jiahong, primary, Suyama, Kimita, primary, Qian, Xia, primary, Qian, Bin-Zhi, primary, Bandyopadhyay, Sanmay, primary, Loudig, Olivier, primary, De Leon-Rodriguez, Carlos, primary, Zhou, Zhen Ni, primary, Segall, Jeffrey, primary, Macian, Fernando, primary, Norton, Larry, primary, and Hazan, Rachel B., primary

Published
2023
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40. Supplementary Figure 4 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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42. Supplementary Figures 1-3 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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43. Data from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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44. Supplementary Figure 6 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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45. Supplementary Figure 5 from Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Author

Agiostratidou, Georgia, primary, Li, Maomi, primary, Suyama, Kimita, primary, Badano, Ines, primary, Keren, Rinat, primary, Chung, Su, primary, Anzovino, Amy, primary, Hulit, James, primary, Qian, Binzhi, primary, Bouzahzah, Boumediene, primary, Eugenin, Eliseo, primary, Loudig, Olivier, primary, Phillips, Greg R., primary, Locker, Joseph, primary, and Hazan, Rachel B., primary

Published
2023
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46. Supplementary Figure 2 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

Author

Kim, Seaho, primary, Yao, Jiahong, primary, Suyama, Kimita, primary, Qian, Xia, primary, Qian, Bin-Zhi, primary, Bandyopadhyay, Sanmay, primary, Loudig, Olivier, primary, De Leon-Rodriguez, Carlos, primary, Zhou, Zhen Ni, primary, Segall, Jeffrey, primary, Macian, Fernando, primary, Norton, Larry, primary, and Hazan, Rachel B., primary

Published
2023
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47. Supplementary Figure 3 from Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

Author

Kim, Seaho, primary, Yao, Jiahong, primary, Suyama, Kimita, primary, Qian, Xia, primary, Qian, Bin-Zhi, primary, Bandyopadhyay, Sanmay, primary, Loudig, Olivier, primary, De Leon-Rodriguez, Carlos, primary, Zhou, Zhen Ni, primary, Segall, Jeffrey, primary, Macian, Fernando, primary, Norton, Larry, primary, and Hazan, Rachel B., primary

Published
2023
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