1. Highly oxidized guaiane 12(8),15(6)-dilactones with neuroprotective activities from the roots of Lindera aggregata (Sims) Kosterm.
- Author
-
Ma LF, Lou SQ, Chen HY, Luo D, Guo L, Chen NY, Wu R, Fang L, and Zhan ZJ
- Subjects
- Molecular Structure, Oxidation-Reduction, Sesquiterpenes, Guaiane chemistry, Sesquiterpenes, Guaiane pharmacology, Sesquiterpenes, Guaiane isolation & purification, Mice, Lactones pharmacology, Lactones chemistry, Lactones isolation & purification, Animals, Cell Survival drug effects, Cell Line, Structure-Activity Relationship, Dose-Response Relationship, Drug, Models, Molecular, Neuroprotective Agents pharmacology, Neuroprotective Agents chemistry, Neuroprotective Agents isolation & purification, Plant Roots chemistry, Lindera chemistry
- Abstract
In our search for neuroprotective agents, six previously undescribed highly oxidized guaiane sesquiterpenes, linderaggrols A-F (1-6), together with three known sesquiterpenes, were isolated from the roots of Lindera aggregata (Sims) Kosterm. Their structures including absolute configurations were established by a combination of NMR spectroscopic techniques and single crystal X-ray diffraction experiments. Compounds 1-6 represented the first instances of guaiane 12(8),15(6)-dilactones. Additionally, compound 6 possessed a rare 1,8-O-bridge. Neuroprotective effects against erastin-induced ferroptosis on HT-22 cells showed that some compounds demonstrated neuroprotective effects at 20.0 μM., Competing Interests: Declaration of competing interest All the authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in the paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF