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15 results on '"Lou, Weigang"'

11. The Treatment of Avulsion Fracture of the Calcaneal Tuberosity: A New Technique of 180-Degree Annular Internal Fixation

Author

Xu,Ding, Lou,Weigang, Li,Ming, and Chen,Jianming

Subjects
Clinical Interventions in Aging
Abstract

Ding Xu,* Weigang Lou,* Ming Li, Jianming Chen Department of Orthopedic Trauma Surgery, Ningbo No.6 Hospital, Ningbo, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ding Xu Email xuding831129@126.comAbstract: Due to the traction of the Achilles tendon and osteoporosis, a large number of reports have shown that a series of complications such as skin flap necrosis and failure of internal fixation after surgery often cause nonunion or malunion of calcaneal tuberosity fractures. At the same time, there is no uniform standard for the operative procedure in the treatment of the avulsion fractures of the calcaneal tuberosity. We presented a new technique for the treatment of avulsion fractures of the calcaneal tuberosity, which is fixed with a 180-degree microplate. We aim to provide a simple, safe, and strong internal fixation technique for avulsion fractures of the calcaneal tuberosity as one of the treatment options.Keywords: 180-degree annular internal fixation, avulsion fractures of the calcaneal tuberosity, new technique

Published
2021

15. Berberine Attenuates IL-1 β -Induced Damage of Nucleus Pulposus Cells via Activating the AMPK/mTOR/Ulk1 Pathway.

Author

Huang L, Chen J, Wu D, Wang K, Lou W, and Wu J

Subjects
AMP-Activated Protein Kinases metabolism, Animals, Apoptosis, Autophagy-Related Protein-1 Homolog metabolism, Cells, Cultured, Extracellular Matrix metabolism, Interleukin-1beta metabolism, Rats, TOR Serine-Threonine Kinases metabolism, Berberine pharmacology, Intervertebral Disc Degeneration drug therapy, Intervertebral Disc Degeneration metabolism, Nucleus Pulposus metabolism
Abstract

Intervertebral disc degeneration (IDD) is a chronic progressive condition mainly caused by excessive inflammatory cytokines. Berberine (BBR) exerts anti-inflammatory effect on diseases and protective effect against IDD. However, the mechanism is not uncertain. This study is aimed at investigating the molecular mechanism of BBR on IDD. Nucleus pulposus (NP) cells were treated with BBR at different concentrations. The IDD rat model was established by acupuncture. The effect of BBR on interleukin- (IL-) 1 β -induced cell proliferation was measured by CCK-8 assay and BrdU staining. The role of BBR in IL-1 β -induced apoptosis, autophagy repression, and extracellular matrix (ECM) degradation was measured by Annexin/PI staining, immunofluorescence, and immunoblot. The effect of BBR on IDD was investigated in rat. Our findings showed that BBR restored cell growth and attenuated apoptosis in IL-1 β -induced NP cells. BBR also prevented the IL-1 β -induced ECM degradation through regulating ECM-related enzymes and factors. Additionally, BBR significantly activated autophagy repressed by IL-1 β . Autophagy stimulated by BBR was diminished by the inhibition of the AMPK/mTOR/Ulk1 signaling pathway. In vivo study also showed BBR attenuated intervertebral disc degeneration. BBR could attenuate NP cells apoptosis and ECM degradation induced by IL-1 β through autophagy by the AMPK/mTOR/Ulk1 pathway. This study suggests BBR might function as an AMPK activator to alleviate IDD progression., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2022 Liaoyuan Huang et al.)

Published
2022
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