67 results on '"Lotufo, P. Andrade"'
Search Results
2. Are Neighborhood Greenspaces Associated with Leisure-time Physical Activity? Results from ELSA-Brasil Eight-year Follow-up
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Almeida, Luciene Fátima Fernandes, Barreto, Sandhi Maria, Conceição Chagas Almeida, Maria, Bensenor, Isabela Judith, Lotufo, Paulo Andrade, Molina, Maria Del Carmen Bisi, Cardoso, Letícia de Oliveira, and Giatti, Luana
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- 2024
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3. Effects of environmental exposure to iron powder on healthy and elastase-exposed mice
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Galli, Thiago Tafarel, de Campos, Elaine Cristina, do Nascimento Camargo, Leandro, Fukuzaki, Silvia, dos Santos, Tabata Marayama, Hamaguchi, Sara Sumie Sobral, Bezerra, Suellen Karoline Moreira, Silva, Fabio José Alencar, Rezende, Bianca Goulart, dos Santos Lopes, Fernanda Tenório Quirino, Olivo, Clarice Rosa, Saraiva-Romanholo, Beatriz Mangueira, Prado, Carla Máximo, Leick, Edna Aparecida, Bourotte, Christine Laure Marie, Benseñor, Isabela Judith Martins, Lotufo, Paulo Andrade, Righetti, Renato Fraga, and Tibério, Iolanda Fátima Lopes Calvo
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- 2024
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4. Biomarker panels for fruit intake assessment: a metabolomics analysis in the ELSA-Brasil study
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Silva, Alexsandro Macedo, Levy, Jéssica, De Carli, Eduardo, Cacau, Leandro Teixeira, de Alvarenga, José Fernando Rinaldi, Benseñor, Isabela Judith Martins, Lotufo, Paulo Andrade, Fiamoncini, Jarlei, Brennan, Lorraine, and Marchioni, Dirce Maria Lobo
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- 2024
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5. Dietary acid load and the risk of events of mortality and kidney replacement therapy in people with chronic kidney disease: the Progredir Cohort Study
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Machado, Alisson Diego, Marchioni, Dirce Maria, Lotufo, Paulo Andrade, Benseñor, Isabela Martins, and Titan, Silvia Maria
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- 2024
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6. Association between dietary patterns and carotid intima-media thickness: cross-sectional analysis of ELSA-Brasil study
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Cacau, Leandro Teixeira, Levy, Jéssica, Alves, Mariane de Almeida, Santos, Itamar de Souza, Fonseca, Maria de Jesus Mendes, Lotufo, Paulo Andrade, Benseñor, Isabela Martins, and Marchioni, Dirce Maria
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- 2023
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7. Adherence to the EAT-Lancet sustainable reference diet and cardiometabolic risk profile: cross-sectional results from the ELSA-Brasil cohort study
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Cacau, Leandro Teixeira, Benseñor, Isabela Martins, Goulart, Alessandra Carvalho, Cardoso, Leticia de Oliveira, Santos, Itamar de Souza, Lotufo, Paulo Andrade, Moreno, Luis A., and Marchioni, Dirce Maria
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- 2023
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8. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Factors Related to Smoking Cessation
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Lopes de Oliveira, Thaís, Oliveira, Raquel Vasconcellos Carvalhaes de, Griep, Rosane Harter, Moreno, Arlinda B., Melo, Enirtes Caetano Prates, Lotufo, Paulo Andrade, Toivanen, Susanna, and Fonseca, Maria de Jesus Mendes da
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- 2022
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9. Cognitive outcomes of the bipolar depression electrical treatment trial (BETTER): a randomized, double-blind, sham-controlled study
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Tortella, Gabriel, Sampaio-Junior, Bernardo, Moreno, Marina L., Moffa, Adriano H., da Silva, Adriano Fernandes, Lafer, Beny, Lotufo, Paulo Andrade, Gattaz, Wagner, Borrione, Lucas, Machado-Vieira, Rodrigo, Goerigk, Stephan, Benseñor, Isabela M., and Brunoni, Andre R.
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- 2021
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10. Insulin resistance may be misdiagnosed by HOMA-IR in adults with greater fat-free mass: the ELSA-Brasil Study
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Zaniqueli, Divanei, de Oliveira Alvim, Rafael, Griep, Rosane Harter, Benseñor, Isabela Martins, Barreto, Sandhi Maria, Lotufo, Paulo Andrade, and Mill, José Geraldo
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- 2021
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11. Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study
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Meneghini, Vandrize, Tebar, William Rodrigues, Santos, Itamar Souza, Janovsky, Carolina Castro Porto Silva, de Almeida-Pititto, Bianca, Birck, Marina Gabriela, Lotufo, Paulo Andrade, Goulart, Alessandra Carvalho, Sgarbi, José Augusto, Teixeira, Patrícia de Fátima dos Santos, Silva, Gisela Tunes da, and Benseñor, Isabela Martins
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- 2024
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12. Association between carotid intima‐media thickness and cognitive decline differs by race.
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Ferreira, Naomi Vidal, Bertola, Laiss, Santos, Itamar S., Goulart, Alessandra C., Bittencourt, Marcio S., Barreto, Sandhi Maria, Giatti, Luana, Caramelli, Paulo, Pereira, Alexandre, Lotufo, Paulo Andrade, Bensenor, Isabela M., and Suemoto, Claudia Kimie
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INTRODUCTION: Common carotid intima‐media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT and cognitive decline. METHODS: In this longitudinal analysis of the ELSA‐Brasil, we assessed cIMT using ultrasound and cognitive performance using different domain tests. We used linear mixed models, interaction analysis, and race stratified analyses. RESULTS: Baseline high IMT values were associated with memory (p < 0.001), verbal fluency (p < 0.001), TMT‐B (p < 0.001)), and global cognitive decline (p < 0.001). Race was an effect modifier in the association between IMT and global cognitive decline (0.043), with stronger association in White (p < 0.001) than in Black (p = 0.009) participants. DISCUSSION: Baseline IMT was associated with global and domain‐specific cognitive decline and race modified this relationship, with stronger associations in White participants. Highlights: Carotid intima‐media thickness (cIMT) was associated with cognitive decline.cIMT and cognitive decline association was stronger in White than in Black participants.We used inverse probability weighting to address attrition bias. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Epicardial fat thickness: distribution and association with diabetes mellitus, hypertension and the metabolic syndrome in the ELSA-Brasil study
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Graeff, Daniela Bertol, Foppa, Murilo, Pires, Julio Cesar Gall, Vigo, Alvaro, Schmidt, Maria Ines, Lotufo, Paulo Andrade, Mill, Jose Geraldo, and Duncan, Bruce Bartholow
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- 2016
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14. Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations
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Tamashiro-Duran, Jaqueline Hatsuko, Squarzoni, Paula, de Souza Duran, Fábio Luís, Curiati, Pedro Kallas, Vallada, Homero Pinto, Buchpiguel, Carlos Alberto, Lotufo, Paulo Andrade, Wajngarten, Mauricio, Menezes, Paulo Rossi, Scazufca, Márcia, de Toledo Ferraz Alves, Tânia Corrêa, and Busatto, Geraldo Filho
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- 2013
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15. CYP2C9 and VKORC1 polymorphisms influence warfarin dose variability in patients on long-term anticoagulation
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Santos, Paulo Caleb Junior Lima, Dinardo, Carla Luana, Schettert, Isolmar Tadeu, Soares, Renata Alonso Gadi, Kawabata-Yoshihara, Liz, Bensenor, Isabela Martins, Krieger, José Eduardo, Lotufo, Paulo Andrade, and Pereira, Alexandre Costa
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- 2013
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16. Mortalidade precoce por doenças do coração no brasil. Comparação com outros países
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Lotufo Paulo Andrade
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epidemiologia ,doenças do coração ,mortalidade ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
OBJETIVO: Comparar a mortalidade por doenças do coração e pela doença coronária (DC) nas faixas etárias dos 45 aos 64 anos, no período 1984-87, em capitais brasileiras com outros países. MÉTODOS: Foram utilizadas as estatísticas oficiais de mortalidade de 8 capitais com boa qualidade de informação: Belém, Recife, Salvador, Belo Horizonte, Rio de Janeiro, São Paulo, Curitiba e Porto Alegre e analisadas as doenças do coração [DC (410-414), mais insuficiência cardíaca (428), mais hipertensão (401-404)] e, isoladamente, a DC. A população foi a determinada nos Censos Demográficos de 1980 e 1991. RESULTADOS: A comparação com outros países mostrou que: a) as taxas de mortalidade por doenças do coração situam algumas cidades brasileiras na posição intermediária (Hungria, Rio de Janeiro, Finlândia, Porto Alegre e Polônia) e entre as mulheres no topo (Rio de Janeiro, Curitiba, Hungria, Porto Alegre, Inglaterra e Gales); b) DC apresentou o mesmo padrão (intermediário alto) das doenças do coração entre os homens (Finlândia, Hungria, Inglaterra e Gales, Porto Alegre e Rio de Janeiro). Entre as mulheres, repetiu-se a situação das doenças do coração (Rio de Janeiro, Curitiba, Hungria, Porto Alegre, Inglaterra e Gales). CONCLUSÃO: A comparação com outros países das taxas de mortalidade ajustadas por idade na faixa etária dos 45-64 anos no período 1984-87 mostrou que as cidades brasileiras estudadas têm altas taxas de mortalidade para as doenças do coração, principalmente entre as mulheres, em valores tão ou mais elevados do que os da Europa e dos Estados Unidos.
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- 1998
17. ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas
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Burim, Regislaine Valéria, Teixeira, Silvia Aparecida, Colli, Benedicto Oscar, Peria, Fernanda Maris, Tirapelli, Luis Fernando, Marie, Suely Kazue Nagahashi, Malheiros, Suzana Maria Fleury, Oba-Shinjo, Sueli Mieko, Gabbai, Alberto Alain, Lotufo, Paulo Andrade, and Carlotti-Júnior, Carlos Gilberto
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- 2009
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18. Estimation of underreporting of energy intake using different methods in a subsample of the ELSA-Brasil study.
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Oliveira, Priscila Santana, Levy, Jéssica, De Carli, Eduardo, Bensenor, Isabela Judith Martins, Lotufo, Paulo Andrade, Pereira, Rosangela Alves, Yokoo, Edna Massae, Sichieri, Rosely, Crispim, Sandra Patricia, and Marchioni, Dirce Maria Lobo
- Abstract
Copyright of Cadernos de Saude Publica is the property of Escola Nacional de Saude Publica Sergio Arouca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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19. Mortality from asthma in the state of S. Paulo, Brazil (1970-1992)
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Lotufo Paulo Andrade, Martins Benseñor Isabela Judith, and Lolio Cecília Amaro de
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Asthma/mortality ,Mortality rate ,Public aspects of medicine ,RA1-1270 - Abstract
Mortality from asthma has shown important variations over time in several countries. In Brazil, a mortality study performed in the 60s, covering the cities of S.Paulo and Ribeirão Preto, and other ten cities showed that S.Paulo presented the lowest death rate from asthma among of them all. It was decided to study the time trends of deaths from asthma and from the whole set of respiratory diseases from 1970 to 1992, in the population aged 15-34 yrs. old in the State of S.Paulo, as well as to compare them with those of other countries. Asthma mortality rates during the 23 years of observation since 1975, showed an oscillatory declining pattern with a peak of deaths in the initial years. The linearization of the curve allows the calculation of Pearson's correlation coefficient that was significantly negative, suggesting a decline in the mortality over this period, mainly in the 5-9 yrs. old and 30-34 yrs. old strata. The segmentation of data between the period of ICD-9, 1970 to 1978, and of ICD-9, 1979 and subsequent years, shows that there is stability within each period, in all age-groups, except for that of 5-9 yr. olds between 1970-1978. Comparing the rates of the population aged 15-34 yrs. old for the State of S. Paulo, Brazil, with trends observed in 14 other countries, an intermediate pattern for the first triennial period (1970-1972) as well as for the subsequent triennial periods, emerges. A prevalence study of asthma, a follow up program meant for using emergency rooms and a surveillance of deaths due to all respiratory diseases and specifically to asthma are strongly recommended.
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- 1995
20. Hipertensão arterial e possíveis fatores de risco
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Lolio Cecília Amaro de, Pereira Júlio César Rodrigues, Lotufo Paulo Andrade, and Souza José Maria Pacheco de
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Hipertensão/epidemiologia ,Fatores de risco ,Public aspects of medicine ,RA1-1270 - Abstract
São apresentados resultados de um estudo de prevalência de hipertensão arterial realizado no Município de Araraquara, SP, Brasil, em 1987, que avaliou 1.199 pessoas, sendo 533 homens e 666 mulheres, de 15-74 anos de idade. Os resultados mostram alta prevalência da doença, maior no sexo masculino (32,0%) do que no feminino (25,3%), com tendência crescente com a idade, até os 49 anos (homens) e até os 59 anos (mulheres). Houve, também, maior percentagem de hipertensos nos grupos étnicos preto e pardo, nos obesos e naqueles de menor renda, menor escolaridade e ocupação em estratos inferiores. No entanto, a regressão logística mostrou "odds ratios" muito pequenos, associados a estes fatores, o que pode decorrer da maneira como os mesmos foram considerados.
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- 1993
21. Lower paraoxonase 1 paraoxonase activity is associated with a worse prognosis in patients with non-ST-segment elevation myocardial infarction in long-term follow-up
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Leocádio, Paola Caroline Lacerda, Goulart, Alessandra Carvalho, Santos, Itamar Souza, Lotufo, Paulo Andrade, Bensenor, Isabela Martins, and Alvarez-Leite, Jacqueline Isaura
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- 2022
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22. Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study.
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Lelis, Deborah de Farias, Calzavara, João Vitor S., Santos, Raul D., Sposito, Andrei C., Griep, Rosane Härter, Barreto, Sandhi Maria, Molina, Maria del Carmen B., Schmidt, Maria Inês, Duncan, Bruce B., Bensenor, Isabella, Lotufo, Paulo Andrade, Mill, José Geraldo, and Baldo, Marcelo Perim
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CARDIOVASCULAR diseases risk factors ,REFERENCE values ,TRIGLYCERIDES ,CARDIOVASCULAR diseases ,SEX distribution ,HIGH density lipoproteins ,ETHNIC groups ,RECEIVER operating characteristic curves ,LONGITUDINAL method - Abstract
• We defined the sex- and ethnicity-specific reference values for the TG/HDL-C. • A large sample of healthy adults was defined based on the whole ELSA-Brasil study. • The TG/HDL-C did not change with age, regardless of sex and ethnicity. • A sex-specific cut-off (men 2.6; women 1.7) may be used in an admixed population. • TG/HDL-C is a reliable predictor of cardiometabolic risk for clinical use. Among several lipid ratios available, the triglyceride/HDL-cholesterol (TG/HDL-C) may detect individuals at risk of cardiometabolic diseases. However, its reference values for different ethnicities are not well established. To define sex- and ethnicity-specific reference values for TG/HDL-C ratio in a large sample of healthy multiethnic adults and test its association with cardiometabolic conditions. An apparently healthy sample (n = 2,472), aged 35–74, free of major cardiovascular risk factors, was used to generate the reference values for the TG/HDL-C. Exclusion criteria were diabetes, elevated blood pressure, obesity, hypercholesterolemia, severe hypertriglyceridemia, and smoking history. Cut-offs based on the reference values were tested in the whole ELSA Brasil study (n = 13,245), stratified by sex and ethnicity, to identify cardiometabolic conditions. TG/HDL-C ratio was higher in men than women, and did not change significantly with age, regardless of sex and ethnicity. Also, black individuals showed lower levels of TG/HDL-C as compared to other ethnic groups. ROC curve showed that the cut-off based on the 75th percentile displayed better sensitivities and specificities for men and women, regardless of ethnicity. Also, the sex- and ethnicity-specific cut-offs based on the 75th percentile were significantly associated with all tested cardiometabolic conditions (hypertension, diabetes, obesity, metabolic syndrome, and insulin resistance). Also, we observed that the use of a single sex-specific cut-off (men: 2.6; women: 1.7) could be used for the different ethnicities with good reliability. The defined TG/HDL-C cut-offs (men: 2.6; women: 1.7) are reliable and showed good clinical applicability to detect cardiometabolic conditions in a multiethnic population. [ABSTRACT FROM AUTHOR]
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- 2021
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23. The association between salt intake and blood pressure is mediated by body mass index but modified by hypertension: The ELSA-Brasil study
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Chagas, Suellen Ferreira, Zaniqueli, Divanei, Baldo, Marcelo Perim, Lotufo, Paulo Andrade, Duncan, Bruce B., Griep, Rosane Harter, Benseñor, Isabela Martins, de Oliveira Alvim, Rafael, and Mill, José Geraldo
- Abstract
High salt intake has been linked to both obesity and high blood pressure (BP). Part of the variability of BP attributed to salt intake might be BMI-mediated. To investigate whether hypertension would be an effect modifier in the complex network including salt intake, obesity, and BP, we tested the hypothesis that salt intake has direct and BMI-mediated effects on systolic (SBP) and diastolic blood pressure (DBP). Data from 9,028 participants (aged 34–75 years, 53.6% women) were analyzed. A validated formula was used to estimate daily salt intake from the sodium excretion (12 h urine collection). A path model adjusted for covariates was designed in which salt intake has both a direct and a BMI-mediated effect on BP. In normotensives, standardized beta coefficients showed significant direct (Men: 0.058 and 0.052, Women: 0.072 and 0,061, P< 0.05) and BMI-mediated (Men: 0.040 and 0.065, Women: 0.038 and 0.067, P< 0.05) effect of salt intake on the SBP and DBP, respectively. However, in hypertensive individuals, neither the direct (Men: 0.006 and 0.056, Women: 0.048 and 0.017) nor the indirect effect (Men: −0.044 and 0.014, Women: 0.011 and 0.050) of salt intake on the SBP and DBP were significant. These data suggest that cardiovascular risk stratification should consider the complex interaction between salt intake and weight gain, and their effects on BP of normotensive and hypertensive individuals.
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- 2022
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24. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. Stagi, Lambert, C., Jauregui, V., Laliotis, A., Marquez, D., Krichmar, P., Watts, S., Kozlowski, J., Sanchez, E., Kotha, P., Godfrey, C., Korpas, D., Averett, P., Kindman, L., Khan, G., Khan, M., Binns, M., Khan, B., DiCorcia, L., Kesselbrenner, M., Buhler, A., Kersh, R., Bartholomaus, D., Kerkering, M., Keller, J., Keller, R., Davis, C., Kastelic, R., Behm, K., Karunaratne, H., Ruggiero, M., Kapoor, A., Cook, S., Kaplan, K., Kostedt, G., Kandath, D., Dugal, J., Kai, W., Coombs, V., Kahn, B., Royes, A., Judson, P., Nichols, M., Jovin, I., Hughett, G., Jones, R., Phillips, T., Johnson, F., Andresen, T., Jardula, M., Butcher, S., Ison, R., Tambawala, M., Hussain, M., Garza, M., Hurst, P., Battistelli, E., Hunter, J., Truva, C., Huang, P., Craft, D., Howard, L., Hays, D., Howard, V., Adams, K., Houchin, V., Turner, N., Hotchkiss, D., Sloss, D., Horton, K., Homayouni, A., Homan, J., Young, C., Hoekstra, J., Dutter, S., Hippert, R., Vieira, P., Hinchman, D., Carey, G., Herson, S., Miranda, D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., 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H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
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Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
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- 2017
25. Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment.
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SANTOS, Itamar de Souza, SUEMOTO, Claudia Kimie, VALLADÃO-JUNIOR, José Benedito Ramos, LIU, Simin, BARRETO, Sandhi Maria, FEDELI, Ligia Maria Giongo, LOTUFO, Paulo Andrade, and BENSENOR, Isabela Martins
- Abstract
Copyright of Arquivos de Neuro-Psiquiatria is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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26. Magnesium intake in a Longitudinal Study of Adult Health: associated factors and the main food sources.
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Levy, Jéssica, Machado Miranda, Andreia Alexandra, Araujo Teixeira, Juliana, De Carli, Eduardo, Martins Benseñor, Isabela Judith, Lotufo, Paulo Andrade, and Marchioni, Dirce Maria Lobo
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MAGNESIUM ,FISH as food ,LONGITUDINAL method ,MINIMUM wage ,NUTS ,SOCIODEMOGRAPHIC factors ,HUMAN skin color - Abstract
Copyright of Revista Ciência & Saúde Coletiva is the property of Associacao Brasileira de Pos-Graduacao em Saude Coletiva and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
- Full Text
- View/download PDF
27. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
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Pan, Y. F., Lim, G., Desire, A., Tseng, W. K., Rost, Natalia S., Grammer, M., Khetarpal, S., Waseem, M., Zellner, C., Roper, E., Amin, M., Harden, M., Sababathi, R., Valpas, S., Bourlios, P., Kawaguchi, A., Mavronasiou, E., Pandurangi, U., Shams, S., Dichristin, U., Purayil, M. Padinhare, Munemasa, M., Angel, J., Gurusamy, P., Berni, A., Platner, N., Zeltser, D., El Jarroudi, M., Kisos, D., Haruna, T., Bernhardt, P., Coisne, D., Nakahara, Y., Li, W. M., Karamitsos, C., Tziortziotis, A., Essop, M., Nunkoo, T., Gani, M., Wilson, L., Kelfkens, Y., Mitha, I., Taljaard, J., Naidoo, D., Duki, Y., Snyders, F., Munnik, M., Soma, P., Johnston, H., Patki, N., Jasani, B., Van Der Merwe, N., Goosen, Y., Van Zyl, L., Le Roux, M., Venter, T., Wessels, L., Bae, H. J., Han, M. G., Cha, J. K., Kim, D. H., Cho, B. R., Ryu, D. R., Choi, H. H., Hong, K. S., Chung, W. S., Oh, Y. S., Han, S. H., Lee, K. H., Hong, T. J., Lee, H. W., Hyon, M. S., Jung, J. W., Jeon, H. K., Lee, J. M., Kang, D. H., Choi, K. J., Kim, C. J., Jin, E. S., Kim, D. S., Seo, J. S., Kim, H. S., Cha, M. J., Kim, J. T., Park, M. S., Kim, J. H., Park, J. H., Kim, J. S., Parekh, P., Vicente, C., Simoes, M., Carraro, A., Sobral Filho, D., Lustosa, E., Boas, F. Villas, Almeida, M., Zimmermann, S., Zimmermann, E. Burger, Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Matsushita, C., Premchand, R., Boyer, M., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Kartsagkoulis, E., Kaplan, P., Sopher, M., Young, G., Senior, R., Roberts, J., Mackin, A., Moriarty, A., Olympios, C., Green, M., Shandra, T., Zhurba, S., Logvinov, Y., Zharinov, O., Mudruk, I., Yena, L., Nahrebetskyy, V., Kraiz, I., Chompalova, B., Parishev, G., Kharalkar, H., Knezevic, A., Denchev, S., Usan, N., Kraydashenko, O., Milcheva, N., Stets, R., Donova, T., Gergova, V., Georgiev, B., Kostova, E., Goudev, A., Jaksic Jurinjak, S., Kinova, E., Hergeldjieva, V., Yagensky, A., Kamenova, P., Manolova, A., Vasilev, I., Mihov, A., Miteva, B., Kupnovytska, I., Mincheva, V., Jelic, V., Stoyanovski, V., Makar Ausperger, K., Nikolov, F., Vasilev, D., Pencheva, G., Kostov, K., Petranov, S., Boriani, G., Milusheva, T., Popov, A., Staneva, A., Momchilova-Lozeva, D., Francetic, I., Todorov, G., Nyagina, M., Tumbev, H., Tumbeva, D., Tzekova, M., Kitova, M., Manoylov, E., Dicker, D., Giovannelli, F., Archibald, J., Antle, S., Bhargava, R., Stafford, C., Bose, S., Hundseth, M., Cha, J., Otis, J., Romic, I., Ferri Certic, J., Chehayeb, R., Lepage, C., Tusek, S., Ciglenecki, N., Jeric, M., Chilvers, M., Car, S., Carevic, V., Vansickle, L., Kyyak, Y., Serik, S., Cleveland, D., Valley, S., Constance, C., Gauthier, M., Lasri, E., Costi, P., Masson, C., Coutu, B., Denis, I., du Preez, M., Kubanska, A., Dufresne, M., Krider, J., Eikelboom, J., Zondag, M., Fortin, C., Viau, C., Houbraken, D., Hatheway, R., Mabee, J., Bagatin, J., Lizogub, V., Atar, S., Heath, J., Scott, L., Ho, K., Perdomo Mejia, I., Ho, V., Hoag, G., Standring, R., Huynh, T., Perkins, L., Kouz, S., Roy, M., Labonte, R., Fuki, Y., Dewar, C., Lainesse, A., St-Germain, L., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Sanchez Vallejo, G., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Roth, M., Mucha, M., Volkov, V., Goncharov, O., Vizir, V., Sklyanna, O., Vatutin, M., Drapchak, I., Vakaliuk, I., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. Vijan, Kaur, A., Marciano, C., Varma, S., Tykhonova, S., Kuznetsov, I., Tseluyko, V., Najarali, A., Lamoureux, U., Nicholson, R., O'Hara, G., Banville, P., O'Mahony, W., Bolton, R., Parkash, R., Carroll, L., Pesant, Y., Sardin, V., Polasek, P., Turri, L., Qureshi, A., Nethercott, C., Ricci, J., Gonzales, C., Gorna, O., Bozek, B., Rupka, D., Malynovsky, Y., Quintero, A., Belhassane, A., Fonseca, J., Orozco Linares, L., Marchand, C., Shu, D., Silverio, G., St-Hilaire, R., Fedotov, S., Morissette, A., Sussman, J., Ostrovska, L., Kailey, P., Syan, G., Lopez Giraldo, D., Moncada Corredor, M., Bobbie, C., Rivera Rodriguez, E., Talajic, M., David, D., Manzur, F., Talbot, P., Tremblay, M., Teitelbaum, I., Teitelbaum, J., Velthuysen, G., Giesbrecht, L., Wahby, R., Morley, A., Wharton, S., Caterini, T., Builes, A., Dimitra, K., Ajioka, M., Woodford, T., Balboa, W., Ushakova-Sokolova, L., Parkhomenko, A., Dovgan, N., Potapenko, P., Nekrasa, A., Prokhorov, O., Leonidova, V., Rebrov, B., Gamachek, O., Jaramillo Munoz, C., Daskalaki, A., Thankaraj, L., Moschos, N., Delgado, P., Hernandez, H., Aldana Diaz, I., Fernandez Ruiz, R., Arroyave, C., Delgado Restrepo, J., Leon Pineda, L., Srinivas, A., Cano, N., Accini, M., Accini, J., Zhang, Y. L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Rishko, M., Chendey, T., Han, R. J., Zhao, R. P., Retamal Matus, L., Bugueno, C., Mondaca Mondaca, P., Cobos, J., Obreque, C., Corbalan, R., Parada, A., Kang, H., Gupta, R., Singh, G., Lyzohub, S., Florenzano, F., Arratia Diaz, P., Lopetegui, M., Rebolledo, C., Manriquez, L., Manriquez Silva, L., Martinez, D., Romero Llamas, R., Opazo, M., Carmona Perez, M., Pincetti, C., Torres Carrasco, G., Zhang, Z., Lin, Y. N., Rudyk, I., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Potthoff, S., Zapata Staub, J., Rodriguez, M., Campisto, Y., Xu, Y. P., Stockins, B., Lara Lara, C., Yovaniniz, P., Grandon Azua, M., Bai, F., Xu, G. L., Chen, J. Z., Xie, X. D., Chen, X. P., Zhang, X., Yin, Y. H., Gao, M., Dong, Y. G., Feng, C., Fu, G. S., Zhang, P., Miyauchi, Y., Hong, K., You, Z. G., Shatilo, V., Ishchuk, V., Zheng, Y., Hong, L., Zheng, X., Qiu, Y., Yang, Y. J., Shcherbak, V., Sudheer, R., Shetty, G., Li, A. Y., Goncharova, I., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shvetz, N., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Sychov, O., Liao, D. N., Liu, Y., Zamlynskyy, M., Sirenko, Y., Stanislavchuk, M., Sethia, S., Sethia, A., Jiang, X. J., Li, Z. Q., Qu, Z., Li, L., Perebetiuk, L., Liu, H., Kandekar, B., Li, T. F., Liu, B., Raut, N., Kong, Y. Q., Hashimoto, Y., Jakala, P., Shimazu, Y., Hiasa, Y., Berger, N., Kale, V., Alexopoulos, D., Wurow, A., Filardi, P. Perrone, Al-Zoebi, A., Hoffmann, S., Viitaniemi, J., Dias, P., Oomaan, A., Murata, J., Natarajan, S., Narendra, J., Shelke, S., Duprat, C., Winter, K., Roudaut, R., Wolde, C., Buelow-Johansen, B., Oga, Y., Namjoshi, D., Lee, M. H., Leparree, S., Poulard, J., Nagai, Y., Sakata, Y., Naito, S., Oyama, H., Nishi, Y., Nagase, T., Ochiai, J., Junko, H., Ogawa, T., Sugeno, M., Oguro, H., Tanabe, M., Okada, K., Corbut, S., Moriyama, Y., Okajima, K., Nakashima, M., Okazaki, O., Wada, H., Kacet, S., Okishige, K., Kitani, S., Okumura, K., Deruche, E., Hermida, J., Dorn, S., Tsalihin, D., Hoffmann, U., Dieckheuer, U., Heuer, H., Winkelmann, B., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Antman, Elliott M., Mercuri, Michele F., Ito, Y., Onishi, M., Iwade, K., SomaRaju, Bhupathi, Nicolau, Jose C., Singhal, Aneesh B., Silverman, Scott, Norden, Andrew D., Crompton, Andrea E., Murphy, Sabina A., Ruff, Christian T., Giugliano, Robert P., Narita, Y., Onaka, H., Moriyama, H., Ozaki, Y., Tanikawa, I., Sakagami, S., Nakano, A., Sakuragi, S., Hayashi, N., Sakurai, S., Ooki, H., Sasaki, T., Braunwald, Eugene, Oosawa, N., Satoh, A., Fujimoto, E., Seino, Y., Narumi, M., Shirai, T., Shigenari, M., Shoji, Y., Ueda, J., Manuela, W., Fuchs, R., Schneider, K., Sakuma, Y., Forck-Boedeker, K., Arfaoui, M., Dinanian, S., Joshi, H., Faghih, M., Weyland, K., Park, S. J., Kim, S. H., Buchholz, M., Seo, J. B., Kim, Y. J., Aggarwal, R., Smith, S., Beeton, I., Dunn, S., Blagden, M., Ito, T., Vogelmann, O., Gonzalez, C., Ahuad Guerrero, R., Belatsky, V., Swissa, M., Aloni, I., Sugi, K., Miyazaki, E., Price, R., Sumii, K., Camm, J., Asakura, H., Dougal, K., Chapman, O., Davies, D., Choy, A., Duff, J., Cohen, A., Wilmott, R., D'Costa, D., Douglas, H., Dickinson, D., Lie, F., Ramasamy, V., Lindsay, S., Takagi, M., Mohri, S., Takahashi, W., Yoshida, K., Voehringer, Voehringer, Thomas, R., Herfurth, B., Ludwig, I., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Veltkamp, R., Agraou, B., Zarpentin, C., Taggeselle, J., Stoehring, R., Shochat, M., Sterlin, J., Iwasaki, T., Schiff, E., Takahashi, A., Albisu, J., Rosales, E., Atkinson, C., Allall, O., Kishi, N., Linker, N., Finlayson, M., Bonin, K., Lip, G., Spitzer, S., Masaki, W., Akihisa, U., Hirahara, T., Furiozzi, F., Zaca, V., Takahashi, T., Sakurai, Y., Baylacher, M., Reguero, M., Sohn, H., Takeda, K., Gold, G., Yahata, A., Takenaka, T., Yamagishi, K., El Jarroudi, F., Sethi, K., Seibert, H., Takeuchi, S., Gagliano, M., Toschi, V., Breschi, M., Severi, S., Hussi, E., Watanabe, E., Cannoni, S., Rasura, M., Singh, R., Brown, R., Sawhney, J., Arora, T., Iesaka, Y., Higashikata, T., Miyamoto, C., Nagatome, H., Iijima, T., Higuchi, K., Kaarleenkaski, S., Ino, H., Hellmers, J., Noguchi, H., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Daut, W., Kakinoki, S., Finsterbusch, T., Adachi, C., Schenkenberger, I., Frommhold, R., Lioy, E., Penco, M., Schellong, S., Inomata, T., Nakamura, K., Kamakura, S., Granzow, K., Nakahara, F., Kamijo, M., Iida, S., Tanaka, K., Raisaro, A., Uchida, M., Tanouchi, J., Kamiyama, K., Nishiya, Y., Tsuboi, H., Tsuboi, N., Fujii, R., Terakura, K., Kato, K., Ishida, A., Kazatani, Y., Uematsu, M., Yasumoto, S., Ueyama, Y., MacCallum, P., Usuda, K., Sakai, Y., Yagi, M., Sato, A., Yagi, H., Kuroda, T., Yamabe, H., Ichikawa, Y., Sakamoto, Y., Yamada, T., Yamano, R., Kitazawa, H., Alvarez, C., Yamagishi, T., Sasaki, S., Yamamoto, Y., Yamashina, A., Chun, M. Y., Joung, B. Y., Igarashi, C., Ebano, P., Takiguchi, M., Yamashita, T., Matsuda, K., Yonehara, T., Yoshino, H., Nomura, H., MacLeod, M., Yoshioka, K., Fujiwara, Y., Bayram Llamas, E., Hurtado, A., Calvo Vargas, C., Cedano Limon, M., Kobayashi, Y., Cardona Munoz, E., Hernandez, S., Carrillo, J., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Delgadillo, T., Casares Ramirez, M., Franco Valles, J., Pilipenko, H., Rack, K., Garcia, M., Ameriso, S., Ameriso, P., Garcia, N., Alcantara Colin, M., Garcia-Castillo, A., McGhee, C., Jaramillo, A., Leiva-Pons, J., de la Mora, S., Marazzi, P., Llamas Esperon, G., Grajales, A., Amuchastegui, M., Jones, D., Mendez-Machado, G., Avila, H., Nevarez Ruiz, L., Magallanes, G., Sanchez Diaz, C., Ortiz, A., Kuhlmann, M., Maxwell, T., Velasco Sanchez, R., Logvinenko, S., Moran Velazquez, E., Isted, C., Alhakim, M., More, R., Helliwell, L., van Welsen, I., Bruning, T., Caceres, M., Jones, A., Buiks, C., de Groot, J., Radder, I., de Vos, R., Beloscar, J., Hazeleger, R., Daniels, R., Kietselaer, B., Muijs, L., Mannaerts, H., Kooiman, E., Mevissen, H., van der Heijden, D., Hofmeyer, H., Anscombe, R., O'Meeghan, T., Kjentjes, M., Benatar, J., White, H., Borthwick, L., Doughty, R., Copley, M., Fisher, R., Monkley, R., Green, B., Scott, D., Hamer, A., Tomlinson, J., Hart, H., Turner, A., Cammell, R., Troughton, R., Skelton, L., Young, C., Kennett, K., Atar, D., Claussen, H., Hofsoy, K., Melbue, R., Sandvik, J., Thunhaug, H., Tveit, A., Enger, S., Bustamante, G., Tejada Guillen, M., Cabrera, J., Esteves Mendoza, R., Chavez, C., Luna, C., Lema, J., Rozenman, Y., Givoni, H., Carrion, A., Proskynitopoulos, N., Pohl, W., Llerena, N., Lewinsky, D., Araoz Bedregal, S., Medina Palomino, F., Rodriguez, J., Minchola, J., Bautista, C., Negron Miguel, S., Honores Armas, B., Rodriguez, A., Romero, N., Torres, P., Murdoch, D., Fernandez Rodriguez, K., Yanac Chavez, P., Horna, M., Delgado, S., Babilonia, N., Sambaz, C. M., Piechatzek, R., Raddatz, K., Barcinas, R., Mueller-Glamann, M., Francis, V., Menon, J., Sharma, P., Mathur, A., Zapanta, M., Fenu, L., Coching, R., Vallenas, M., Matiga, G., Enad, C., Rogelio, G., Joaquin, F., Roxas, A., Gilo, L., Ouzan, E., Amarenco, P., To, R., Aquino, M., Villamor, L., Nario, K., Adamus, J., Korzeniowska-Adamus, J., Baszak, J., Bronisz, M., Karny, M., Bhaskarwar, P., Hara, S., Boursin, P., Babuty, D., Naganuma, M., Lee, S. H., Shin, D. G., Piseddu, G., Namgung, J., Andrews, A., Sarna, M., Cieslak, B., Newby, D., Busz-Papiez, B., Krzystolik, A., Cymerman, K., Dabrowska, M., Ptak, A., Derlaga, B., Laskowska-Derlaga, E., Domanska, E., Guziewicz, M., Gieroba, A., Zajac, E., Gniot, J., Mroczkowski, P., Januszewicz, A., Makowiecka-Ciesla, M., Huikuri, H., Jazwinska-Tarnawska, E., Flint, L., Paradiso, G., Ratnik, E., Ciezak, P., Jurowiecki, J., Kaczmarek, B., Pacholska, A., Kaminski, L., Kania, G., Tymendorf, K., Karczmarczyk, A., Kaliszczak, R., Konieczny, M., Benicka, E., Korzeniak, R., Borowski, W., Pye, M., Krzyzanowski, W., Muzyk-Osikowicz, M., Sklodowskiej-Curie, M., Jadhav, D., Hagiwara, N., Wright, L., Kus, W., Lesnik, J., Kamitake, C., Wierzykowski, T., Lewczuk, J., Furukawa, Y., Stopyra-Poczatek, M., Lubinski, A., Szymanska, K., Lysek, R., Jaguszewska, G., Matyszczak-Toniak, L., Sznajder, R., Wnetrzak-Michalska, R., Kosmaczewska, A., Mazur, S., Chmielowski, A., Miekus, P., Kosmalska, K., Mosiewicz, J., Myslinski, W., Napora, P., Petrucci, J., Berli, M., Biniek, D., Nessler, J., Nessler, B., Niezgoda, K., Nej, A., Nowak, J., Olszewski, M., Podjacka, D., Budassi, N., Janczewska, D., Itamoto, K., Pogorzelska, H., Ise, M., Valle, M., Bustamante Labarta, G., Polaszewska-Pulkownik, V., Bojanowska, E., Raczak, G., Zienciuk-Krajka, A., Rewinska, H., Rozmyslowicz-Szerminska, W., Yamaguchi, A., Ronkowski, R., Ruzyllo, W., Norwa-Otto, B., Sendrowski, D., Spyra, J., Szolkiewicz, M., Vahula, V., Malanska, A., Turbak, R., Wrobel, W., Muzalewski, P., Wysokinski, A., Avery, D., Kennard, S., Storey, R., Bridge, C., Turner, W., Walker, M., Rajasalu, R., Venkataraman, A., Gilchrist, M., Kudlicki, J., Zarebinski, M., Rosenthal, A., Krauze, R., Zielinski, M., Nawrot, M., Matias, F., Correia, J., Gil, V., Lopes, S., Madeira, J., Maymone, D., Sant, H., Martins, D., Neves, E., Monteiro, P., Oliveira, D., Leitao Marques, A., Salgado, A., Goncalves, A., Santos, O., Veiga Pais Nunes, L., Santos, J., Barbera, S., Soares, D., Albulescu, P., Joseph, J., Bulgari, M., Funazaki, T., Metra, M., Ciortea, M., Apetrei, E., Lishner, M., Matei, C., Bartos, D., Badila, E., Bengus, C., Ochean, V., Bobescu, E., Doka, B., Bolohan, F., Ciobotaru, G., Andor, M., Coman, I., Ghionea, M., Constantinescu, M., Creteanu, M., Oommen, D., Watkin, R., Chung, A., Wright, A., Wright, J., Parasteac, M., Cristea, M., Joseph, S., Anciu, M., Crisu, D., Pahuja, M., Jemna, D., Jain, R., Ghume, A., Hiremath, J., Thakor, G., Saravia, M., Caccavo, A., Muegge, A., Hardas, S., Dobre, I., Voicu, O., Dobreanu, D., Sirbu, I., Dragomir, D., Savanth, P., Jurca, S., Iosipescu, L., Costache, L., Minescu, B., Serban, D., Pop, C., Cozma, M., Popescu, M., Ardelean, A., Sipciu, D., Plosca, P., Stamate, S., Spinu, C., Topolnitchi, L., Tudoran, M., Tudoran, C., Zhukova, N., Arutyunov, G., Chernyavskaya, T., Ballyuzek, M., Alexandrova, L., Barbarash, O., Bashkireva, A., Voitk, J., Fujimoto, C., Bart, B., Larina, V., Belenky, D., Kosolapov, Y., Berns, S., Yukhno, E., Bokarev, I., Khlevchuk, T., Chumakova, G., Pokutneva, O., Demko, A., Masin, A., Dovgalevsky, P., Puchinyan, N., Drapkina, O., Fracaro, V., Cartasegna, L., Zyatenkova, E., Egorova, L., Esip, V., Kirichek, N., Filatov, A., Soin, I., Gilinskaya, O., Valuyshkih, E., Glezer, M., Valovyeva, S., Golitsyn, S., Kratskina, T., Goloshchekin, B., Laptev, I., Gratsiansky, N., Mazovets, O., Karpov, Y., Buza, V., Kosenko, B., Vogt, S., Khirmanov, V., Kireenkov, I., Khokhlov, A., Sinitsina, O., Khokhlov, R., Novas, V., Tsareva, E., Khrustalev, O., Khrustalev, A., Kostenko, V., Karabalieva, S., Koziolova, N., Polyanskaya, E., Kozyrev, O., Kostenko, O., Kuznetsov, V., Paumets, M., Rychkov, A., Lavrova, O., Tereschenko, L., Levashov, S., Volkova, E., Libis, R., Maslova, A., Libov, I., Kwak, J. J., Moiseeva, Y., Lila, A., Belousova, L., Lukyanov, Y., Lamden, D., Nikolaev, K., Nikolaev, A., Nikolskaya, I., Khromova, O., Novikova, N., Patrusheva, S., Panchenko, E., Laguta, P., Panov, A., Nilk, R., Polkanova, E., Matveeva, I., Poluyanova, N., Pikalova, N., Raskina, T., Letaeva, M., Rebrov, A., Karoli, N., Repin, M., Rodina, N., Shaposhnik, I., Lebedev, E., Shogenov, Z., Agirov, M., Sidorenko, B., Vorontsova, S., Sinitsina, I., Orlov, V., Sizova, Z., Rha, S. W., Caruso, O., Saa Zarandon, R., Lapidus, N., Sobolev, K., Na, J. O., Colombo, H., Morandini, M., Cuello, J., Erofeeva, S., Suprun, E., Dronov, D., Fukuda, N., Harada, J., Tarasov, N., Isakov, L., Tereshenko, S., Fukamizu, S., Kositsyna, I., Tikhonova, E., Solovyev, A., Timofeev, A., Bulygin, S., Ustyugov, S., Rossovskaya, M., Vishnevsky, A., Kirgizova, A., Volkov, D., Yakusevich, V., Petrochenko, A., Yakushin, S., Nikulina, N., Zateyshchikov, D., Zotova, I., Zateyshchikova, A., Mankhaeva, B., Zenin, S., Kononenko, O., Rim, S. J., Kim, J. Y., Zubeeva, G., Motylev, I., Apostolovic, S., Arcocha Torres, M., Djordjevic-Radojkovic, D., Manzanal Rey, A., Blanco Coronado, J., Puertas, I., Bruguera Cortada, J., Maenpaa, A., Cabero, P., Calvo, C., Rosell, M., Calvo, G., De Arce Borda, A., Asensio, A., Diez Tejedor, E., Perez Guevara, M., Celic, V., Gonzalez Juanatey, J., Laheaar, M., Moure, M., Lucijanic, T., Mitrovic, V., Frahm, E., Mardikar, H., Hernandez Madrid, A., Lappalainen, T., Delgado, A., Lopez Garcia-Aranda, V., Barquero, R., Meyer-Pannwitt, U., Kale, M., Lavhe, P., Anthony, A., Majstorovic, A., Kumbla, M., Adjic, N. Cemerlic, Bjelobrk, M., Despotovic, N., Erceg, P., Ilic, S., Ilic, B., Krotin, M., Djokovic, A., Miloradovic, V., Djokic, I., Otasevic, P., Tasic, N., Potpara, T., Polovina, M., Putnikovic, B., Kalezic, T., Cuneo, C., Seferovic, P., Milinkovic, I., Tavciovski, D., Davicevic, Z., Vasiljevic-Pokrajcic, Z., Mitrovic, P., Tesic, B. Vujisic, Ostojic, M., Castro, C., Manzano, L., Blanco Abril, S., Rivis, L., Merino, J., Topolnitchi, O., Diaz-Pintado, M., Bocanera, M., D'Amico, A., Cendali, G., Dran, R., Moreno, V., Arias, J., Ruda, M., Golshmid, M., Fernandez, M., Fernandez Alvarez, R., Terns, M., Tesic, M., Ambrovicova, V., Ambrovic, I., Banikova, A., Dukat, A., Dachs Delgado, M., Kosmalova, V., Dulkova, K., Dulka, T., Francis, J., Kumar, A., Duris, T., Estol, C., Davolos, M., Vankova, L., Villuendas, R., Astier, L., Appelros, P., Dzupina, A., Dzupinova, M., Hatalova, K., Hatala, R., Akerberg, A., Karpuram, M., Facello, A., Hranai, M., Hofmanova, J., Blom, K. Berndtsson, Facello, M., Falu, E., Kasperova, V., Kumar, P., Lawande, A., Reptova, A., Mazur, J., Pella, D., Fedacko, J., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Fisher, M., Yousuf, K., Dongas, B., Yi, J., Preston, S., Yasin, M., Kulkarni, G., Sheehan, T., Andersson, R., Blomstrom, P., Persson, L., Carlsson, T., Bengtsson, A. Stener, Hadan, S., Iriarte, M., Femenia, F., Arrieta, M., Fuselli, J., Deokar, M., Kulkarni, R., Zanotti, A., Dettmann, S., Ostberg, S., Engdahl, J., Karlsson, L., Herlitz, J., Winberg, L., Juul-Moller, S., Jernhed, H., Koskinen, P., Hakansson, E., Kozak, P., Edlund, M., Malmqvist, L., Eriksson, G., Singh, P., Randers, F., Moodh, J., Gupta, J., Saini, A., Rautio, A., Johansson, M., Goyal, N., Ronn, F., Sundholm, C., Stenberg, A., Gunnarsson, A., Thulin, J., Broberg, M., Yarows, S., Moccetti, T., Slater, I. Petrova, Cheng, C. C., Wu, W. S., Mostert, M., Engelbrecht, J., Botha, L., Pointer, S., Worley, S., Capasso-Gulve, E., Wood, K., VonGerichten, S., Willis, J., Mali, N., Chopda, M., Babbolin, M., Merlini, P., Francalacci, G., Fujita, T., Karnwal, N., Somaraju, B., Marino, P., Raggi, F., Calambur, N., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. Gonzalez, Val-Mejias, J., Hanna, K., Updegrove, J., Salas, L., Ruffini, L., Morsky, J., Ellis, G., Bhuti, M., Biniwale, A., Slanina, M., Kmec, J., Tucker, P., Torres, M., Southam, D., Teixeira, J., Mitchell, T., Tee, H., Young, K., Teague, S., Dastoli, K., Tawney, K., Swauger, M., Tatarko, M., Corchado, D., Zachar, A., Kokles, M., Zareczky, P., Gant Lopez, J., Tami, L., Leo, L., Talano, J., Bruton, T., Takata, T., Springer, K., Tahirkheli, N., Herwehe, S., Szulawski, I., Rathi, A., Bhargava, V., Solanki, R., Kotiwale, V., Freemyer, D., Swerchowsky, V., Bharani, A., Frost, J., Suresh, D., Surushe, S., Vittitow, T., Struble, R., Benjarge, P., Kikuchi, R., Braemer, U., Cox, C., Steljes, A., Liu, M., Staniloae, C., McCartney, P., Spivack, E., Vasquez, E., Sperling, M., Thomason, L., Spangenthal, S., Hodnett, P., Smith, R., Keene, R., Hughes, B., Skierka, R., Nelson, M., Singh, V., Turner, K., Singh, N., Meiller, F., Garcia Duran, R., Laane, E., Chiang, C. E., Perlo, D., Garrido, M., Ceirano, C., Giacomi, G., Meyer, R., Simpson, P., Champagne, M., Siler, T., Kohno, M., Yu, W. C., Stephenson, L., Shoukfeh, M., Sheth, T., Tamura, S., Banker, D., Reddy, J., Browning, J., Babu, R., Rao, B., Nyman, K., Sankari, T., Shih, H., Rasi, H., Babu, P., Meissner, G., Shaikh, A., Lo Pinto, G., Hengerer, T., Sheikh, K., Hren, A., Shaoulian, E., Fleets, J., Eden, M., Shanes, J., Koretsune, Y., Seese, M., Avvaru, G., Shalaby, A., Witt, P., Shah, G., Mather, N., Seide, H., Holt, A., Ullig, T., Seals, A., Mercer, S., Schulman, D., Schneider, W., Schneider, R., Fekete, A., Schaefer, S., Clifton, R., Savin, V., Lafave, J., Sandberg, J., Schomburg, J., Samal, A., Ball, E., Sacco, J., Nelson, T., Giannaula, R., Ruoff, G., Freeman, R., Ross, S., Martin, C., Allman, J., Dalby, A., Rosen, R., Barnhorst, M., Chiang, F. T., Rosado, J., Wu, Y. W., Chiou, C. W., Hollihan, P., Yeh, T. C., Roehll, W., Cherrico, M., Robinson, J., Braun, D., Riofrio, K., Pazier, P., Richwine, R., Stanley, E., Renzi, M., Wroblewski, J., Redondo, V., Domingo, D., Rama, P., Hoefer, K., Hemmen, C., Quinn, J., Reed, C., Quinlan, E., Rafla, E., Quadrel, M., Ebert, J., Maus, O., Pugeda, J., Sham, L., Pudi, K., Nakagawa, Y., Lowe, K., Ben Ari, M., Huerta, M., Pribble, A., Neeper, L., Pratt, R., Cush, S., Poulathas, A., Kirk, D., Pezzella, S., Gaggioli, G., Brown, F., Pettis, K., Morlando, F., Petruzziello, F., Chacon, L., Lewis, B., Peters, P., Goicoechea, R., von Wulffen, M., Hominal, M., Bianchini, M., Jure, H., Jure, D., Kevorkian, R., Duncan, D., Pentz, W., Montayne, S., Pearlstein, R., Gorry, N., Pavon, H., Dennison, K., Patnam, S., Joseph, L., Oza, S., Gonzalez, M., Osborne, J., Garcia, L., Orchard, R., McCormick, J., Oppenheimer, K., Genin, I., Laffi, Laffi, Klainman, E., Monaco, F., Lanternier, G., Belcuore, M., Liniado, G., Iglesias, M., Litvak, B., Nigro, A., Llanos, J., Vignau, S., Lorente, C., Shatsky, K., Lotti, J., Raimondi, G., Mackinnon, I., Carne, M., Manuale, O., Thakkar, N., Hsia, C. H., Chen, Y. P., Huang, J. L., Chen, Y. F., Kuo, C. T., Wang, C. L., Lai, W. T., Lin, T. H., Oberoi, M., Wilmot, M., Nielsen, R., Nomanee, S., Nguyen, T., Goza, J., Lee, J. T., Nallasivan, M., Pai, P. Y., Lin, K. H., West, M., Naidu, J., Ichishita, Y., Yumoto, I., Parker, A., Nadar, V., Oehmann, V., Murphy, A., Raziano, S., Mullen, P., Todd, S., Mowdy, M., Fujimoto, K., Schuler, C., Mounsey, P., Calderon, M., Marino, J., Parrott, N., Mouhaffel, A., Bowman, B., Majdoub, A., Hayek, T., Roshrosh, M., Morledge, J., Garner, S., Moran, J., Strugatsky, S., Mody, F., Gryczan, J., Miller, S., Sanchez, S., Miller, R., Sanders, D., Milas, J., Romero-Colon, J., Michlin, B., Cajulis, C., Mercado, A., Cervellione, K., Mendelson, R., Wall, J., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., McLaurin, B., Omae, K., Paul, J., McKnight, T., Rodkey, K., McKenzie, M., Miranda, J., McGuire, K., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Hasin, Y., Rabadi-Marar, D., Kurabayashi, M., Marar, I., Mandviwala, M., Dagan, T., Casas, R., Makam, S., Shyu, K. G., Funes, I., Lisiecki, B., Mainigi, S., Fujimoto, S., Muntaner, J., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Kotera, M., Davids, M., Lone, B., Shah, D., Gandur, H., Nul, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Chiu, C. Z., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Ueng, K. C., Bollova, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Verdini, E., Piskorz, D., Tommasi, A., Povedano, G., Casares, E., Pozzer, D., Simmons, T., Lee, S. C., Fujii, E., Kozeni, S., Lang, J., Wang, J. H., Ferguson, D., Landau, C., Coyle, G. Stagi, Lambert, C., Jauregui, V., Laliotis, A., Marquez, D., Krichmar, P., Grossman, E., Watts, S., Kozlowski, J., Sanchez, E., Kotha, P., Godfrey, C., Rouwaida, S., Virtanen, V., Gottlieb, S., Koya, E., Fernandez, E., Prado, A., Korpas, D., Averett, P., Kindman, L., Tsai, W. C., Khan, G., Khan, M., Yeh, H. I., Binns, M., Khan, B., DiCorcia, L., Kesselbrenner, M., Buhler, A., Kersh, R., Bartholomaus, D., Kerkering, M., Keller, J., Keller, R., Davis, C., Kastelic, R., Behm, K., Karunaratne, H., Masuyama, T., Goldhaber, M., Ruggiero, M., Kapoor, A., Cook, S., Kaplan, K., Kostedt, G., Kandath, D., Dugal, J., Fujii, K., Fujiwara, M., Kai, W., Coombs, V., Kahn, B., Royes, A., Nappila, H., Judson, P., Nichols, M., Jovin, I., Hughett, G., Le Heuzey, J., Jones, R., Phillips, T., Johnson, F., Goldhaber, A., Murena, E., Grassia, V., Ghantous, R., Francis, A., Bosco, B., Andresen, T., Jardula, M., Butcher, S., Ison, R., Tambawala, M., Hussain, M., Garza, M., Hurst, P., Battistelli, E., Hunter, J., Huang, P., Craft, D., Howard, L., Hays, D., Howard, V., Adams, K., Houchin, V., Venturini, C., Shree, R., Turner, N., Hotchkiss, D., Sloss, D., Horton, K., Homayouni, A., Homan, J., Hoekstra, J., Dutter, S., Kuo, J. Y., Hippert, R., Vieira, P., Hinchman, D., Ron, G. Avraham, Elias, M., Kaneno, Y., Badenhorst, J., Carey, G., Herson, S., Ebina, E., Meno, H., Arora, V., Endo, H., Memon, A., Fattore, L., Miranda, D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Jirasirirojanakorn, K., Pornchaiyasit, K., Kaewsuwanna, P., Sinthusopa, W., Kiatchoosakun, S., Dandekar, U., Heiman, M., Krater, C., Sriprasert, S., Laothavorn, P., Hearne, S., Bobade, M., Bamrungpong, P., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Piyayotai, D., Hack, T., McLean, R., Gvora, T., Sripracha, A., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Sritara, P., Arneja, J., Ranka, R., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Panpunuan, P., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Ramos, H., Sukonthasarn, A., Mekara, W., Vorasettakarnkij, Y., Agarwal, D., Abdullakutty, J., Puripun, E., Malhan, S., Kincses, M., Vertes, A., Acikel, M., Marosi, A., Tomcsanyi, J., Satake, M., Mita, T., Di Niro, M., Szakal, I., Di Pasquale, G., Akilli, H., Demir, H., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Finkelstein, S., Shriver, D., Ata, N., Bayata, S., Cakmak, N., Finkel, M., Calik, A., Erasmus, L., Basson, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Mazzone, C., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Cayli, M., Fahmy, R., DeSalle, D., Ceyhan, C., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Steward, A., Desai, A., Poynton, M., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., Sipos, T., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., Chang, M., Phan, D., Carr, K., Jameson, L., Caplan, J., Hartranft, E., Canosa, R., Canaday, D., Morton, S., Cader, C., Al-Maliky, T., Bybee, K., Navarrete, S., Ruzsa, D., Triano, A., Brown, H., Frey, W., Brilakis, E., Terry, P., Bradley, A., Ziegler, K., Bowden, W., Simor, T., Wade, W., Bognar, A., Bouchard, A., Hickenbotham, D., Borsheim, M., Vernon, M., Blue, B., Bloomberg, K., Bloomberg, R., Ensminger, E., Blonder, R., Talbot-Lawson, C., Block, T., Antonino, M., Bingham, S., Langone, L., Bilazarian, S., Bilal, B., Eldred, R., Bernard, J., Ibarra, M., Sayour, A., Toth, S. Rostasne, Palinkas, A., Berk, M., Nagy, A., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Kolumban, E., Merkely, B., Kiss, K., Wulf, M., Takeda, M., Benton, J., Bartkowiak, A., Gordon, L., Erdogan, D., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Ermis, C., Alvarez, M., Sanchez, A., Bowen, L., Sanjurjo, M., Codutti, O., Saravia Toledo, S., Formoso, I., Schmidberg, J., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Medvegy, M., Kiss, T., Attanti, S., Matoltsy, A., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Kabul, K., Kanadasi, M., Goloboulicz, A., Anderson, J., Schygiel, P., Buzzetti, C., Severino, P., Morara, P., Sosa Liprandi, M., Teves, M., Vico, M., Oto, A., Turgut, O., Persechino, F., Morell, Y., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Anderson, C., Paraskevaidis, T., Kolk, R., Tandogan, I., Stern, A., Yigit, F., Yigit, Z., Arstall, M., Hoffmann, B., Colquhoun, D., Price-Smith, S., Crimmins, D., Slattery, A., Karakai, H. Horvathne, Lupkovics, G., Di Lenarda, A., Kovacs, Z., Gadepalli, R., Mariani, M., Kumagai, S., Luttermann, M., Krishnan, H., Dart, A., Venneklaas, U., Kay, S., Lueders, S., De Servi, S., Grosse, B., Davis, S., Baranyai, M., Silver, G., Flecknoe-Brown, S., Gates, P., Kovacs, I., Salminen, O., Koczka, M., Jakal, A., Jones, S., Pirelli, S., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Lehman, R., Kiss, R., Saha, D., Barai, A., Roy, D., Bekal, S., Feil, J. Felfoldine, Meusel, P., Morrison, H., Biscardi, R., Kis, E., Hirayama, A., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Kosztyu, M., Kleinecke-Pohl, U., Alexander, J., Brubaker, S., Akhter, F., Schoen, B., Reddy, R., Shankar, A. Ravi, Jungmair, W., Schmid, S., Junggeburth, J., De Pace, D., Ahmadpour, H., De Caterina, R., Hussain, A., Kaik, J., Ahmad, A., Beck, P., Zoghi, M., Batushkin, V., Fink, P., Reiling, S., Miyamoto, N., Adler, P., McKeirnan, M., Li, J., Paul, V., Batta, C., Serup-Hansen, K., Vuriya, A., Horacek, T., Schuppe, M., Kanakaridisz, N., Varga, A., Kimizu, T., Purnell, P., Perrett, L., Kishore, R., Szto, G., O'Shea, V., Capiau, L., Banaeian, F., De Bleecker, J., de Koning, K., De Tollenaere, M., Kara, M., Fiok, J., Szatmari, J., De Bruyne, L., Edes, I., Tsukimine, A., Muskoczki, E., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Forgione, C., Harada, K., Dioszeghy, P., Almaraz, S. Padilla, Desfontaines, P., Tincani, G., Heidbuchel, H., Camas, L. Velasquez, Cuccia, C., Meeusen, K., Herzet, J., Malmendier, D., Guerra, L., Mairesse, G., Raepers, M., Parque, J., Clinckemaille, N., Scavee, C., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Arakawa, S., Huyberechts, D., Stockman, D., Jacobs, C., Vandekerckhove, Y., Svenningsen, A., Sand, N., Azhdari, M., Derycker, K., Peruzzotti, L., Comi, G., Vanwelden, J., Mino, K., Cervi, E., Sanchez, M., Gilat, T., van Welden, J., Vervoort, G., Mestdagh, I., Vrolix, M., Bazylevych, A., Vlasyuk, Z., Raae, D., Raymond, I., Beerts, C., Wollaert, B., Denie, D., Vincenzo de Paola, A. Amato, Coutinho, E., Lotufo, P. Andrade, de Melo, R. Ferreira, Atie, J., Motta, C., Alves da Costa, F. Augusto, Lahav, M., Estrada, M. Rodas, Ferraz, R. Franchin, Precoma, D. Bertolim, Guevara, S., Contzen, C., Weihrauch, D., Sehnem, E., Botelho, R., Cunha, S., Brondani, R., Fleck, N., Buhr, M., Kandekar, S., Ladenburger, K., Lavagnino, A. Ovando, Braun, R., Ishimaru, S., Chaves Junior, H., Silva, J., Costantini, C., Barroso, D., Jimenez, T., De Patta, M., Pereira, V., Duda, N., Bereznyakov, I., Laimer, R., Tomita, H., Ishii, Y., Dutra, O., Morgado, S., Saporito, W. Faustino, Seroqui, M., Ferreira, L., Araujo, E., Finimundi, H., Daitz, C., Gagliardi, R., Pereira, G., Gomes, M., Gomes, A., Guimaraes, A., Lebedynskaya, M., Petrovic, V., Overgaard, K., Ninho, L., Olsen, R., Nielsen, H., Jaeger, C., Barash, B., Veng-Olsen, T., Dotsenko, S., Pereira, L., Iversen, H., Madsen, H., Kulynych, R., Dzyak, G., Vasilyeva, L., Faynyk, A., Sorokivskyy, M., Gavrysyuk, V., Schnelzer, P., Ibsen, H., Adler, J., Dzublik, Y., Horbach, L., Husyev, V., Bouzo, M., Babbar, A., Loof, A., Blanc, J., Godlevska, O., Melgar, I. Guzman, Marcoviciu, D., Ramirez, V. de Leon, Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Decoulx, E., Samburg, Y., Jorge, J., Cury, C., Karpenko, O., Hassager, C., Milla, O. Ayau, Kaiser, S., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Almeida, A., Kalil, C., Radaelli, G., Sebba Barroso de Souza, W. Kunz, Morales, K., Labrova, R., Nevolina, I., Karpenko, Y., Leaes, P., Luiz, R. Osorio, Blihar, O., Kaydashev, I., Berbari, H., Spinar, J., Spacek, R., Almeida, J. Pimenta, Gozalo, A., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Gerasimenko, N., Pisova, J., Exarchou, E., Havlova, I., Petrova, I., Kifnidis, K., Reis, G., Kolomyyits, S., Peterka, K., Olsr, J., Bansal, N., Nechanicky, R., Vasylets, V., Kopytsya, M., Melichar, M., Krocova, E., Machova, V., Ludka, O., Petyunina, O., Kotseruba, V., Berrouschot, J., Kvasnicka, J., Avellar, K., Kuchar, R., Kovar, P., Katz Weiand, L. Reis, Korantanis, K., Kosek, Z., Kostkova, G., Leipelt, J., Rocha, J., Ishibashi, Y., Lohman, J., Panella, M., Nozaki, T., Abi-Mansour, P., Dvoieglazova, M., Pyrgakis, V., Koval, V., Ohirko, O., Kochrt, M., Kobza, R., Koval', O., Jirmar, R., Sakamoto, S., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Barros, R., Gregor, P., Rao, M., Jambula, H., Golan, L., Anzai, T., Rodrigues, L., Rocha, M. Rubia, Rodrigues, A., Rodrigues, D., dos Santos, F. Rossi, Pagnan, L. Goncalves, Sampaio, R., do Val, R., Saraiva, J., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Pinto, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Pyridines ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Recurrence ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,parasitic diseases ,Secondary Prevention ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,business.industry ,Hazard ratio ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,Middle Aged ,medicine.disease ,nervous system diseases ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,TIMI ,medicine.drug - Abstract
Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
28. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48
- Author
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Seibert, H., Bolton, R., Florian, J., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., David, D., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Eikelboom, J., Krider, J., Dufresne, M., Kubanska, A., du Preez, M., Talbot, P., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. 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Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Finsterbusch, T., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Bobbie, C., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., You, Z. G., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Talajic, M., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Fortin, C., Gilchrist, M., Zondag, M., Dewar, C., Lainesse, A., Roth, M., Viau, C., St-Germain, L., Mucha, M., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Nicholson, R., Venkataraman, A., Walker, M., Lamoureux, U., Wright, L., Ebano, P., Storey, R., Price, R., Pye, M., Flint, L., Newby, D., Andrews, A., Murdoch, D., Helliwell, L., Blagden, M., MacCallum, P., Kennard, S., Sopher, M., Young, G., Senior, R., Brown, R., Lip, G., Najarali, A., Dunn, S., More, R., Isted, C., Maxwell, T., Jones, D., Standring, R., Hoag, G., Marazzi, P., McGhee, C., Ho, V., Ho, K., Scott, L., MacLeod, M., O'Hara, G., Heath, J., Finlayson, M., Hatheway, R., Beeton, I., Linker, N., Wright, J., Wright, A., Chung, A., Watkin, R., Atkinson, C., Houbraken, D., Lindsay, S., Turner, W., Ramasamy, V., Lie, F., Avery, D., Bridge, C., Douglas, H., D'Costa, D., Wilmott, R., Duff, J., Huynh, T., Camm, J., Perkins, L., Kouz, S., Roy, M., Labonte, R., Choy, A., Davies, D., Chapman, O., Dougal, K., and Yalcin, R.
- Published
- 2016
29. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
-
Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. Gonzalez, Val-Mejias, J., Hanna, K., Updegrove, J., Salas, L., Tucker, P., Romero, N., Torres, M., Southam, D., Teixeira, J., Mitchell, T., Tee, H., Young, K., Teague, S., Dastoli, K., Tawney, K., Swauger, M., Tatarko, M., Corchado, D., Tami, L., Leo, L., Talano, J., Bruton, T., Takata, T., Springer, K., Tahirkheli, N., Herwehe, S., Szulawski, I., Freemyer, D., Swerchowsky, V., Frost, J., Suresh, D., Vittitow, T., Struble, R., Cox, C., Steljes, A., Liu, M., Staniloae, C., McCartney, P., Spivack, E., Vasquez, E., Sperling, M., Thomason, L., Spangenthal, S., Hodnett, P., Smith, R., Keene, R., Smith, S., Hughes, B., Skierka, R., Nelson, M., Singh, V., Turner, K., Singh, N., Meyer, R., Simpson, P., Champagne, M., Siler, T., Stephenson, L., Shoukfeh, M., Browning, J., Shih, H., Hengerer, T., Sheikh, K., Hren, A., Shaoulian, E., Fleets, J., Shanes, J., Seese, M., Shalaby, A., Witt, P., Shah, G., Mather, N., Seide, H., Holt, A., Ullig, T., Seals, A., Mercer, S., Schulman, D., Schneider, W., Schneider, R., Fekete, A., Schaefer, S., Clifton, R., Savin, V., Lafave, J., Sandberg, J., Schomburg, J., Samal, A., Ball, E., Sacco, J., Nelson, T., Ruoff, G., Freeman, R., Ross, S., Martin, C., Rosen, R., Barnhorst, M., Rosado, J., Hollihan, P., Roehll, W., Cherrico, M., Robinson, J., Braun, D., Riofrio, K., Roberts, J., Pazier, P., Richwine, R., Stanley, E., Renzi, M., Wroblewski, J., Redondo, V., Domingo, D., Rama, P., Hemmen, C., Quinn, J., Reed, C., Quinlan, E., Rafla, E., Quadrel, M., Ebert, J., Pugeda, J., Sham, L., Pudi, K., Lowe, K., Pribble, A., Neeper, L., Pratt, R., Cush, S., Poulathas, A., Kirk, D., Yovaniniz, P., Pezzella, S., Brown, F., Pettis, K., Morlando, F., Petruzziello, F., Chacon, L., Peters, P., Duncan, D., Pentz, W., Montayne, S., Pearlstein, R., Gorry, N., Pavon, H., Dennison, K., Patnam, S., Joseph, L., Oza, S., Gonzalez, M., Osborne, J., Garcia, L., Orchard, R., McCormick, J., Oppenheimer, K., Thakkar, N., Oberoi, M., Wilmot, M., Nielsen, R., Nomanee, S., Nguyen, T., Goza, J., Nallasivan, M., West, M., Naidu, J., Parker, A., Nadar, V., Oehmann, V., Murphy, A., Raziano, S., Mullen, P., Todd, S., Mowdy, M., Schuler, C., Mounsey, P., Parrott, N., Mouhaffel, A., Bowman, B., Morledge, J., Garner, S., Moran, J., Strugatsky, S., Mody, F., Gryczan, J., Miller, S., Sanchez, S., Miller, R., Sanders, D., Milas, J., Romero-Colon, J., Michlin, B., Cajulis, C., Mercado, A., Cervellione, K., Mendelson, R., Wall, J., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., McLaurin, B., Paul, J., McKnight, T., Rodkey, K., McKenzie, M., Miranda, J., McGuire, K., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Marar, I., Hernandez, S., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. Stagi, Lambert, C., Jauregui, V., Laliotis, A., Marquez, D., Krichmar, P., Watts, S., Kozlowski, J., Sanchez, E., Kotha, P., Godfrey, C., Korpas, D., Averett, P., Kindman, L., Khan, G., Khan, M., Binns, M., Khan, B., DiCorcia, L., Kesselbrenner, M., Buhler, A., Kersh, R., Bartholomaus, D., Kerkering, M., Keller, J., Keller, R., Davis, C., Kastelic, R., Behm, K., Karunaratne, H., Ruggiero, M., Kapoor, A., Cook, S., Kaplan, K., Kostedt, G., Kandath, D., Dugal, J., Kai, W., Coombs, V., Kahn, B., Royes, A., Judson, P., Nichols, M., Jovin, I., Hughett, G., Jones, R., Phillips, T., Johnson, F., Andresen, T., Jardula, M., Butcher, S., Ison, R., Tambawala, M., Hussain, M., Garza, M., Hurst, P., Battistelli, E., Hunter, J., Huang, P., Craft, D., Howard, L., Hays, D., Howard, V., Adams, K., Houchin, V., Caterini, T., Turner, N., Hotchkiss, D., Sloss, D., Horton, K., Homayouni, A., Homan, J., Young, C., Hoekstra, J., Dutter, S., Hippert, R., Vieira, P., Hinchman, D., Carey, G., Herson, S., Miranda, D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Woodford, T., Zhang, Z., Lin, Y. N., Rupka, D., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Zhang, H. Q., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Qiang, H., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., Cohen, A., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., Chang, M., Phan, D., Carr, K., Jameson, L., Caplan, J., Hartranft, E., Canosa, R., Dickinson, D., Canaday, D., Morton, S., Cader, C., Al-Maliky, T., Bybee, K., Triano, A., Brown, H., Frey, W., Brilakis, E., Terry, P., Bradley, A., Ziegler, K., Bowden, W., Wade, W., Bouchard, A., Hickenbotham, D., Borsheim, M., Vernon, M., Blue, B., Bloomberg, K., Bloomberg, R., Ensminger, E., Blonder, R., Talbot-Lawson, C., Block, T., Antonino, M., Bingham, S., Langone, L., Bilazarian, S., Marchand, C., Preston, S., Bilal, B., Eldred, R., Bernard, J., Ibarra, M., Berk, M., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Benton, J., Bartkowiak, A., Gordon, L., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Attanti, S., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Anderson, J., Persechino, F., Amin, M., Khetarpal, S., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Biscardi, R., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Alexander, J., Brubaker, S., Akhter, F., Ahmadpour, H., Hussain, A., Ahmad, A., Beck, P., Aggarwal, R., Reiling, S., Adler, P., Barash, B., Adler, J., Lohman, J., Panella, M., Abi-Mansour, P., Mackin, A., Moriarty, A., Green, M., Shandra, T., Zhurba, S., Logvinov, Y., Zharinov, O., Mudruk, I., Yena, L., Nahrebetskyy, V., Yagensky, A., Serik, S., Volkov, V., Goncharov, O., Vizir, V., Sklyanna, O., Vatutin, M., Drapchak, I., Vakaliuk, I., Tykhonova, S., Kuznetsov, I., Tseluyko, V., Lyzohub, S., Sychov, O., Perebetiuk, L., Stanislavchuk, M., Sirenko, Y., Zamlynskyy, M., Shvetz, N., Goncharova, I., Shcherbak, V., Ishchuk, V., Shatilo, V., Rudyk, I., Chendey, T., Rishko, M., Gamachek, O., Rebrov, B., Leonidova, V., Prokhorov, O., Nekrasa, A., Potapenko, P., Dovgan, N., Parkhomenko, A., Ushakova-Sokolova, L., Ostrovska, L., Fedotov, S., Malynovsky, Y., Gorna, O., Lizogub, V., Kyyak, Y., Kupnovytska, I., Stets, R., Kraydashenko, O., Usan, N., Kraiz, I., Kaplan, P., Koval', O., Ohirko, O., Koval, V., Dvoieglazova, M., Kotseruba, V., Petyunina, O., Kopytsya, M., Vasylets, V., Kolomyyits, S., Gerasimenko, N., Kaydashev, I., Blihar, O., Karpenko, Y., Nevolina, I., Karpenko, O., Samburg, Y., Godlevska, O., Husyev, V., Horbach, L., Dzublik, Y., Gavrysyuk, V., Sorokivskyy, M., Faynyk, A., Vasilyeva, L., Dzyak, G., Kulynych, R., Dotsenko, S., Lebedynskaya, M., Bereznyakov, I., Vlasyuk, Z., Bazylevych, A., Azhdari, M., Batushkin, V., Zoghi, M., Yigit, Z., Yigit, F., Tandogan, I., Turgut, O., Oto, A., Kanadasi, M., Kabul, K., Ermis, C., Erdogan, D., Ceyhan, C., Cayli, M., Calik, A., Cakmak, N., Bayata, S., Ata, N., Demir, H., Akilli, H., Acikel, M., Vorasettakarnkij, Y., Mekara, W., Sukonthasarn, A., Panpunuan, P., Sritara, P., Sripracha, A., Piyayotai, D., Bamrungpong, P., Laothavorn, P., Sriprasert, S., Kiatchoosakun, S., Sinthusopa, W., Kaewsuwanna, P., Pornchaiyasit, K., Jirasirirojanakorn, K., Kuo, J. Y., Yeh, H. I., Tsai, W. C., Wang, J. H., Lee, S. C., Ueng, K. C., Pan, Y. F., Tseng, W. K., Chiu, C. Z., Shyu, K. G., Lin, K. H., Pai, P. Y., Lee, J. T., Lin, T. H., Lai, W. T., Wang, C. L., Kuo, C. T., Mabee, J., Chen, Y. F., Huang, J. L., Chen, Y. P., Hsia, C. H., Yeh, T. C., Chiou, C. W., Wu, Y. W., Chiang, F. T., Yu, W. C., Chiang, C. E., Wu, W. S., Cheng, C. C., Slater, I. Petrova, Moccetti, T., Broberg, M., Thulin, J., Gunnarsson, A., Stenberg, A., Sundholm, C., Ronn, F., Johansson, M., Rautio, A., Moodh, J., Randers, F., Eriksson, G., Malmqvist, L., Edlund, M., Kozak, P., Hakansson, E., Koskinen, P., Jernhed, H., Juul-Moller, S., Winberg, L., Herlitz, J., Karlsson, L., Engdahl, J., Ostberg, S., Dettmann, S., Bengtsson, A. Stener, Carlsson, T., Persson, L., Blomstrom, P., Andersson, R., Blom, K. Berndtsson, Akerberg, A., Appelros, P., Astier, L., Villuendas, R., Dachs Delgado, M., Terns, M., Fernandez Alvarez, R., Fernandez, M., Arias, J., Diaz-Pintado, M., Merino, J., Blanco Abril, S., Manzano, L., Barquero, R., Lopez Garcia-Aranda, V., Delgado, A., Hernandez Madrid, A., Moure, M., Gonzalez Juanatey, J., Perez Guevara, M., Diez Tejedor, E., Asensio, A., De Arce Borda, A., Calvo, G., Calvo, C., Cabero, P., Bruguera Cortada, J., Puertas, I., Blanco Coronado, J., Manzanal Rey, A., Arcocha Torres, M., Kim, J. Y., Rim, S. J., Na, J. O., Rha, S. W., Kwak, J. J., Namgung, J., Shin, D. G., Lee, S. H., Joung, B. Y., Lee, M. H., Chun, M. Y., Kim, Y. J., Seo, J. B., Kim, S. H., Park, S. J., Kim, J. S., Park, J. H., Kim, J. H., Park, M. S., Kim, J. T., Cha, M. J., Kim, H. S., Seo, J. S., Kim, D. S., Jin, E. S., Kim, C. J., Choi, K. J., Kang, D. H., Lee, J. M., Jeon, H. K., Jung, J. W., Hyon, M. S., Lee, H. W., Hong, T. J., Lee, K. H., Han, S. H., Oh, Y. S., Chung, W. S., Hong, K. 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H., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Li, T. F., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rajasalu, R., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Giesbrecht, L., Bagatin, J., Svenningsen, A., Carevic, V., Jiang, X. J., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Talajic, M., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Campisto, Y., Morissette, A., Sussman, J., Gao, M., Frahm, E., Golan, L., Mitrovic, V., Zheng, Y., Zapata Staub, J., Zheng, X., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Kailey, P., Retamal Matus, L., Fonseca, J., Han, R. J., Velthuysen, G., Bugueno, C., Orozco Linares, L., Bobbie, C., Heath, J., Lopez Giraldo, D., Raddatz, K., Zhao, X. L., Voehringer, Voehringer, Scott, L., Ho, K., Ho, V., Chen, X. P., Car, S., Hoag, G., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Kunkelova, V., Najarali, A., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Zhang, X., Dong, Y. G., Standring, R., Feng, C., Fu, G. S., Wang, J. Q., Beeton, I., Dunn, S., Blagden, M., Price, R., Camm, J., Dougal, K., Mondaca Mondaca, P., Chapman, O., Davies, D., Choy, A., Duff, J., Zheng, Z. Q., Wilmott, R., D'Costa, D., Douglas, H., Lie, F., Ramasamy, V., Lindsay, S., Atkinson, C., Moncada Corredor, M., Linker, N., Finlayson, M., Lip, G., Brown, R., MacCallum, P., Ebano, P., MacLeod, M., McGhee, C., Marazzi, P., Maxwell, T., Isted, C., More, R., Helliwell, L., Murdoch, D., Andrews, A., Newby, D., Flint, L., Pye, M., Wright, L., Avery, D., Senior, R., Young, G., Sopher, M., Kennard, S., Storey, R., Zhang, P., Bridge, C., Hong, K., Turner, W., Walker, M., Venkataraman, A., Gilchrist, M., Watkin, R., Chung, A., Wright, A., Wright, J., Cobos, J., Mueller-Glamann, M., Yang, Y. J., Jeric, M., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Berka, L., Xu, J. H., You, Z. G., Li, Y. E., Syan, G., Hoefer, K., Rivera Rodriguez, E., Brodova, P., Ludwig, I., Obreque, C., Manzur, F., Builes, A., Hoffmann, U., Jaramillo Munoz, C., Dorn, S., Veltkamp, R., Hoffmann, S., Li, B. G., Potthoff, S., Bar, M., Vogt, S., Delgado, P., Zhou, S. X., Schuppe, M., Bergovec, M., Muegge, A., Teitelbaum, J., Barbera, S., Horacek, T., Torres Carrasco, G., Vrazic, H., Zhang, Y. L., Ciglenecki, N., Liao, D. N., Pincetti, C., Fink, P., Teitelbaum, I., Carmona Perez, M., Junggeburth, J., Liu, Y., Schmid, S., Li, Z. Q., Jungmair, W., Spitzer, S., Opazo, M., Lu, Z. H., Tusek, S., Ferri Certic, J., Romic, I., Francetic, I., Makar Ausperger, K., Jelic, V., Jaksic Jurinjak, S., Knezevic, A., Lichtenstein, T., Lam, H., Bakliza, Z., Sutalo, K., Lam, S., Romero Llamas, R., Ma, S. M., Huynh, T., St-Germain, L., Luton, R., Accini, J., Lainesse, A., Perkins, L., Douglas, S., Dewar, C., Ma, P., Kouz, S., Kirner, D., Steiner, R., Matthews, J., MacCallum, C., Cvitkusic Lukenda, K., Schoen, B., Kleinecke-Pohl, U., Meusel, P., Koenig, H., Bauch, F., Lohrbaecher-Kozak, I., Grosse, B., Lueders, S., Venneklaas, U., Luttermann, M., Wulf, M., Maus, O., Seib, M., Malette, P., Roberts, P., Yang, Z. Y., Roy, M., Labonte, R., Kong, Y. Q., Samardzic, P., Qu, Z., Hong, L., Buksa, B., Qiu, Y., Tremblay, M., Talbot, P., Accini, M., Hernandez, H., Wang, D. M., Qi, S. Y., Corbalan, R., Wang, G. P., Cano, N., Aldana Diaz, I., Shi, X. J., Martinez, D., Wu, S. L., Fernandez Ruiz, R., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Wei, M., Leon Pineda, L., Arroyave, C., Lopetegui, M., Arratia Diaz, P., Huang, D., Florenzano, F., Parada, A., Bonin, K., Delgado Restrepo, J., Stoehring, R., Taggeselle, J., Zarpentin, C., Huikuri, Heikke, Puripun, E., Yarows, S., Giugliano, Robert P., Scirica, Benjamin M., Wood, K., Sheehan, T., Yasin, M., Worley, S., Ruff, Christian T., Link, Mark S., Pointer, S., Capasso-Gulve, E., Yi, J., Dongas, B., and Yalcin, R.
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Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2016
30. Secondary prevention of coronary heart disease: a cross-sectional analysis on the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
- Author
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Birck, Marina Gabriela, Goulart, Alessandra Carvalho, Lotufo, Paulo Andrade, and Benseñor, Isabela Martins
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- 2019
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31. Cardiovascular and cancer mortality in Brazil from 1990 to 2017.
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Lotufo, Paulo Andrade
- Published
- 2019
- Full Text
- View/download PDF
32. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
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Dougal, K., Venkataraman, A., Murdoch, D., Blagden, M., Dunn, S., MacCallum, P., Young, G., Lip, G., Senior, R., Brown, R., Sopher, M., Ebano, P., Linker, N., Atkinson, C., Lindsay, S., MacLeod, M., More, R., Ramasamy, V., Chapman, O., Lie, F., Beeton, I., McGhee, C., Wilmott, R., Dickinson, D., Douglas, H., Davies, D., D'Costa, D., Finlayson, M., Wright, A., Avery, D., Wright, L., Pye, M., Marazzi, P., Flint, L., Newby, D., Kennard, S., Andrews, A., Storey, R., Helliwell, L., Bridge, C., Choy, A., Turner, W., Walker, M., Wright, J., Smith, S., Jones, D., Maxwell, T., Chung, A., Isted, C., Cohen, A., Camm, J., Price, R., Watkin, R., Gilchrist, M., Duff, J., Aggarwal, R., Eldred, R., Adler, P., Chehayeb, R., Vandekerckhove, Y., Gordon, L., Jones, S., Young, C., Coyle, G. Stagi, Ferguson, D., Lang, J., Simmons, T., Langevin, E., Faucett, S., Ledbetter, L., Royse, H., Lentz, M., Smith, D., Lesser, M., Hartley, L., Lewis, D., Bonds, C., Lillestol, M., Miller, D., Ling, L., Murphy, R., Littlefield, R., Wofford, E., Lomnitz, D., Shah, D., Lone, B., Davids, M., Looby, R., Ault, S., Lui, H., Wright, H., Lurie, M., Edelstein, J., Macomber, J., Bush, D., Magee, A., Doctor, A., Mainigi, S., Lisiecki, B., Makam, S., Casas, R., Mandviwala, M., Hernandez, S., Marar, I., Rabadi-Marar, D., Marenberg, M., Bedenko, E., Massin, E., Hicks, T., McCartney, M., Stubbs, L., McGarvey, J., Schwarz, L., McGuire, K., Miranda, J., McKenzie, M., Rodkey, K., McKnight, T., Paul, J., McLaurin, B., Lack, A., Mega, J., Marti, J., Meholick, A., Skinner, J., Mehrle, A., Wall, J., Mendelson, R., Cervellione, K., Mercado, A., Cajulis, C., Michlin, B., Romero-Colon, J., Milas, J., Sanders, D., Miller, R., Sanchez, S., Miller, S., Gryczan, J., Mody, F., Strugatsky, S., Moran, J., Garner, S., Morledge, J., Bowman, B., Mouhaffel, A., Parrott, N., Mounsey, P., Schuler, C., Mowdy, M., Todd, S., Mullen, P., Raziano, S., Murphy, A., Oehmann, V., Nadar, V., Parker, A., Naidu, J., West, M., Nallasivan, M., Goza, J., Nguyen, T., Nomanee, S., Nielsen, R., Wilmot, M., Oberoi, M., Thakkar, N., Oppenheimer, K., McCormick, J., Orchard, R., Garcia, L., Osborne, J., Gonzalez, M., Oza, S., Joseph, L., Patnam, S., Dennison, K., Pavon, H., Gorry, N., Pearlstein, R., Montayne, S., Pentz, W., Duncan, D., Peters, P., Chacon, L., Petruzziello, F., Morlando, F., Pettis, K., Brown, F., Pezzella, S., Kirk, D., Poulathas, A., Cush, S., Pratt, R., Neeper, L., Pribble, A., Lowe, K., Pudi, K., Sham, L., Pugeda, J., Ebert, J., Quadrel, M., Rafla, E., Quinlan, E., Reed, C., Quinn, J., Hemmen, C., Rama, P., Domingo, D., Redondo, V., Wroblewski, J., Renzi, M., Stanley, E., Richwine, R., Pazier, P., Roberts, J., Riofrio, K., Braun, D., Robinson, J., Cherrico, M., Roehll, W., Hollihan, P., Rosado, J., Barnhorst, M., Rosen, R., Martin, C., Ross, S., Freeman, R., Ruoff, G., Nelson, T., Sacco, J., Ball, E., Samal, A., Schomburg, J., Sandberg, J., Lafave, J., Savin, V., Clifton, R., Schaefer, S., Fekete, A., Schneider, R., Schneider, W., Schulman, D., Mercer, S., Seals, A., Ullig, T., Holt, A., Seide, H., Mather, N., Shah, G., Witt, P., Shalaby, A., Seese, M., Shanes, J., Fleets, J., Shaoulian, E., Hren, A., Sheikh, K., Hengerer, T., Shih, H., Browning, J., Shoukfeh, M., Stephenson, L., Siler, T., Champagne, M., Simpson, P., Meyer, R., Singh, N., Turner, K., Singh, V., Nelson, M., Skierka, R., Hughes, B., Keene, R., Smith, R., Hodnett, P., Spangenthal, S., Thomason, L., Sperling, M., Vasquez, E., Spivack, E., McCartney, P., Staniloae, C., Liu, M., Steljes, A., Cox, C., Struble, R., Vittitow, T., Suresh, D., Frost, J., Swerchowsky, V., Freemyer, D., Szulawski, I., Herwehe, S., Tahirkheli, N., Springer, K., Takata, T., Bruton, T., Talano, J., Leo, L., Tami, L., Corchado, D., Tatarko, M., Swauger, M., Tawney, K., Dastoli, K., Teague, S., Young, K., Tee, H., Mitchell, T., Teixeira, J., Southam, D., Torres, M., Romero, N., Tucker, P., Salas, L., Updegrove, J., Hanna, K., Val-Mejias, J., Harrelson, K. Gonzalez, Vemireddy, D., Cardoza, T., Verma, S., Parsons, T., Vicari, R., Warren, K., Vijay, N., Washam, M., Vossler, M., Kilcup, S., Walsh, R., Renaud, K., Ward, S., Locklear, T., Waxman, F., Sanchez, G., Weiss, R., St Laurent, B., Westcott, J., Truva, C., Williams, D., Gibson, C., Williams, R., Dowling, C., Willis, J., VonGerichten, S., Wood, K., Capasso-Gulve, E., Worley, S., Pointer, S., Yarows, S., Sheehan, T., Yasin, M., Preston, S., Yi, J., Dongas, B., Yousuf, K., Fisher, M., Zakhary, B., Curtis, S., Zeig, S., Mason, T., Zellner, C., Harden, M., Roper, E., Waseem, M., Grammer, M., Ruff, Christian T., Giugliano, Robert P., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Jacobs, C., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., George, F., Valentine, H., Gerber, J., Hinchion, N., Morrison, H., Lehman, R., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Goloboulicz, A., Schmidberg, J., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Gillespie, E., Keane-Richmond, P., Gogia, H., Ewing, B., Goldscher, D., Latteri, J., Goldstein, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Hominal, M., von Wulffen, M., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Iriarte, M., Falu, E., Facello, M., Facello, A., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., 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Perrone, Lioy, E., Penco, M., Bulgari, M., Metra, M., Babbolin, M., Merlini, P., Francalacci, G., Marino, P., Raggi, F., Lo Pinto, G., Gaggioli, G., Laffi, Laffi, Murena, E., Grassia, V., Bosco, B., Fattore, L., Di Niro, M., Di Pasquale, G., Mazzone, C., Di Lenarda, A., Mariani, M., De Servi, S., De Pace, D., De Caterina, R., Forgione, C., Cuccia, C., Peruzzotti, L., Comi, G., Cervi, E., Boriani, G., Giovannelli, F., Berni, A., Platner, N., Zeltser, D., Kisos, D., Tsalihin, D., Belatsky, V., Swissa, M., Aloni, I., Shochat, M., Sterlin, J., Schiff, E., Logvinenko, S., Rozenman, Y., Givoni, H., Ouzan, E., Karny, M., Lishner, M., Ben Ari, M., Lewis, B., Eldadah, Z., Genin, I., Klainman, E., Majdoub, A., Hayek, T., Quick, R., Roshrosh, M., Hasin, Y., Dagan, T., Grossman, E., Rouwaida, S., Gottlieb, S., Goldhaber, M., Goldhaber, A., Ghantous, R., Francis, A., Ron, G. Avraham, Elias, M., Gilat, T., Lahav, M., Marcoviciu, D., Dicker, D., Lasri, E., Atar, S., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. Vijan, Kaur, A., Varma, S., Thankaraj, L., Srinivas, A., Gupta, R., Singh, G., Sudheer, R., Shetty, G., Sethia, S., Sethia, A., Bansal, N., Sethi, K., Singh, R., Sawhney, J., Arora, T., Sarna, M., Jadhav, D., Sant, H., Gadepalli, R., Saha, D., Barai, A., Roy, D., Bekal, S., Reddy, R., Shankar, A. Ravi, Vuriya, A., Rao, M., Jambula, H., Premchand, R., Kharalkar, H., Pinto, B., Babbar, A., Patki, N., Jasani, B., Parekh, P., Sababathi, R., Pandurangi, U., Shams, S., Purayil, M. Padinhare, Angel, J., Gurusamy, P., Oomaan, A., Natarajan, S., Narendra, J., Shelke, S., Namjoshi, D., Francis, V., Menon, J., Sharma, P., Mathur, A., Bhaskarwar, P., Mardikar, H., Kale, M., Lavhe, P., Anthony, A., Kumbla, M., Francis, J., Kumar, A., Karpuram, M., Kumar, P., Lawande, A., Kulkarni, G., Deokar, M., Kulkarni, R., Kotiwale, V., Krishnan, H., Kishore, R., Kandekar, S., Kandekar, B., Raut, N., Kale, V., Joshi, H., Thomas, R., Joseph, J., Oommen, D., Joseph, S., Pahuja, M., Jain, R., Ghume, A., Hiremath, J., Thakor, G., Hardas, S., Savanth, P., Hadan, S., Singh, P., Gupta, J., Saini, A., Goyal, N., Mali, N., Chopda, M., Karnwal, N., Somaraju, B., Calambur, N., Bhuti, M., Biniwale, A., Rathi, A., Bhargava, V., Solanki, R., Bharani, A., Surushe, S., Benjarge, P., Sheth, T., Banker, D., Reddy, J., Babu, R., Rao, B., Babu, P., Shaikh, A., Avvaru, G., Shree, R., Arora, V., Memon, A., Arneja, J., Ranka, R., Agarwal, D., Abdullakutty, J., Malhan, S., Kincses, M., Vertes, A., Marosi, A., Tomcsanyi, J., Szakal, I., Sipos, T., Ruzsa, D., Simor, T., Bognar, A., Sayour, A., Toth, S. Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Seibert, H., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Ellis, J., Cristaldi, J., Finsterbusch, T., Erenrich, N., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rajasalu, R., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Johnson, C., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Golan, L., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., O'Brien, J., Burianova, H., Brtko, M., Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Knezevic, A., Jaksic Jurinjak, S., Ettinger, N., Shipp, A., Jelic, V., Makar Ausperger, K., Francetic, I., Romic, I., Ferri Certic, J., Tusek, S., Ciglenecki, N., Jeric, M., Car, S., Carevic, V., Bagatin, J., Perdomo Mejia, I., Sanchez Vallejo, G., Gonzales, C., Quintero, A., Fonseca, J., Orozco Linares, L., Lopez Giraldo, D., Moncada Corredor, M., Rivera Rodriguez, E., Manzur, F., Builes, A., Jaramillo Munoz, C., Delgado, P., Hernandez, H., Aldana Diaz, I., Fernandez Ruiz, R., Arroyave, C., Delgado Restrepo, J., Leon Pineda, L., Cano, N., Accini, M., Accini, J., Zhang, Y. L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Everhart, B., DeSalle, D., Fahmy, R., Watkins, D., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Feld, L., Zheng, X., Tameron, A., Feldman, J., Tang, N., Felten, W., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Prior, J., Fialkow, J., Calvo, M., Li, Z. Q., Liu, B., Finkel, M., Shriver, D., Finkelstein, S., Fischell, T., Drew, B., Fishbein, G., Donahue, S., Flores, E., Slayton, C., Forman, S., Solis, A., Frais, M., Thrope, C., Franco, M., Gentry, P., French, W., Morales, C., Friedlander, I., Smith, K., Gaffney, M., Jones, J., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., Morissette, A., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Garb, J., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., and Wollaert, B.
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Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,medicine.drug_class ,Pyridines ,Factor Xa Inhibitor ,Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,Dose-Response Relationship, Drug ,business.industry ,Anticoagulant ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background and Purpose— The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate–high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. Methods— We analyzed the subtypes of cerebrovascular events in 21 105 patients participating in Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) comparing outcomes among patients randomized to warfarin versus 2 edoxaban regimens (high dose, low dose). The primary end point for this prespecified analysis of cerebrovascular events was all stroke (ischemic plus hemorrhagic), defined as an abrupt onset of focal neurological deficit because of infarction or bleeding with symptoms lasting ≥24 hours or fatal in Results— Patients randomized to high-dose edoxaban had fewer strokes on-treatment (hazard ratio, 0.80; 95% confidence interval, 0.65–0.98) than warfarin (median time-in-therapeutic range, 68.4%); patients in the low-dose edoxaban group had similar rates (hazard ratio, 1.10 versus warfarin; 95% confidence interval, 0.91–1.32). Rates of ischemic stroke or transient ischemic attack were similar with high-dose edoxaban (1.76% per year) and warfarin (1.73% per year; P =0.81), but more frequent with low-dose edoxaban (2.48% per year; P Conclusions— In patients with atrial fibrillation, once-daily edoxaban was as effective as warfarin in preventing all strokes, with significant reductions in various subtypes of intracranial bleeding. Ischemic cerebrovascular event rates were similar with high-dose edoxaban and warfarin, whereas low-dose edoxaban was less effective than warfarin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2014
33. Subclinical thyroid diseases as a non-classical risk factor for cardiovascular diseases.
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Benseñor, Isabela Martins and Lotufo, Paulo Andrade
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- 2020
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34. Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial.
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Sampaio-Junior, Bernardo, Tortella, Gabriel, Borrione, Lucas, Moffa, Adriano H., Machado-Vieira, Rodrigo, Cretaz, Eric, Fernandes da Silva, Adriano, Fraguas, Renério, Aparício, Luana V., Klein, Izio, Lafer, Beny, Goerigk, Stephan, Benseñor, Isabela Martins, Lotufo, Paulo Andrade, Gattaz, Wagner F., Brunoni, André Russowsky, Fraguas, Renério, Aparício, Luana V, Benseñor, Isabela Martins, and Brunoni, André Russowsky
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BIPOLAR disorder ,TREATMENT effectiveness ,TRANSCRANIAL direct current stimulation ,HAMILTON Depression Inventory ,DIAGNOSIS of mental depression ,MENTAL depression ,THERAPEUTICS - Abstract
Importance: More effective, tolerable interventions for bipolar depression treatment are needed. Transcranial direct current stimulation (tDCS) is a novel therapeutic modality with few severe adverse events that showed promising results for unipolar depression.Objective: To determine the efficacy and safety of tDCS as an add-on treatment for bipolar depression.Design, Setting, and Participants: A randomized, sham-controlled, double-blind trial (the Bipolar Depression Electrical Treatment Trial [BETTER]) was conducted from July 1, 2014, to March 30, 2016, at an outpatient, single-center academic setting. Participants included 59 adults with type I or II bipolar disorder in a major depressive episode and receiving a stable pharmacologic regimen with 17-item Hamilton Depression Rating Scale (HDRS-17) scores higher than 17. Data were analyzed in the intention-to-treat sample.Interventions: Ten daily 30-minute, 2-mA, anodal-left and cathodal-right prefrontal sessions of active or sham tDCS on weekdays and then 1 session every fortnight until week 6.Main Outcomes and Measures: Change in HDRS-17 scores at week 6.Results: Fifty-nine patients (40 [68%] women), with a mean (SD) age of 45.9 (12) years participated; 36 (61%) with bipolar I and 23 (39%) with bipolar II disorder were randomized and 52 finished the trial. In the intention-to-treat analysis, patients in the active tDCS condition showed significantly superior improvement compared with those receiving sham (βint = -1.68; number needed to treat, 5.8; 95% CI, 3.3-25.8; P = .01). Cumulative response rates were higher in the active vs sham groups (67.6% vs 30.4%; number needed to treat, 2.69; 95% CI, 1.84-4.99; P = .01), but not remission rates (37.4% vs 19.1%; number needed to treat, 5.46; 95% CI, 3.38-14.2; P = .18). Adverse events, including treatment-emergent affective switches, were similar between groups, except for localized skin redness that was higher in the active group (54% vs 19%; P = .01).Conclusions and Relevance: In this trial, tDCS was an effective, safe, and tolerable add-on intervention for this small bipolar depression sample. Further trials should examine tDCS efficacy in a larger sample.Trial Registration: clinicaltrials.gov Identifier: NCT02152878. [ABSTRACT FROM AUTHOR]- Published
- 2018
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35. Chronic kidney disease -- determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods.
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Muniz Domingos, Maria Alice, Carvalho Goulart, Alessandra, Lotufo, Paulo Andrade, Martins Benseñor, Isabela Judith, and de Oliveira Titan, Silvia Maria
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- 2017
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36. Trends in cardiovascular diseases and heart disease death rates among adults aged 45-64: Brazil, 2000-2017.
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Lotufo, Paulo Andrade
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- 2019
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37. The pace of reduction of cardiovascular mortality in Brazil (1990 to 2017) is slowing down.
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Lotufo, Paulo Andrade
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- 2019
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38. Effects of diabetes mellitus and systemic arterial hypertension on elderly patients’ hearing
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Rolim, Laurie Penha, Samelli, Alessandra Giannella, Moreira, Renata Rodrigues, Matas, Carla Gentile, Santos, Itamar de Souza, Bensenor, Isabela Martins, and Lotufo, Paulo Andrade
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Chronic diseases can act as an accelerating factor in the auditory system degeneration. Studies on the association between presbycusis and diabetes mellitus and systemic arterial hypertension have shown controversial conclusions.
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- 2018
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39. Knowing for whom the bell tolls: acting locally and thinking globally. Brazil, Latin America and the Global Burden of Diseases, 2015.
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Lotufo, Paulo Andrade
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- 2016
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40. Major Depression as a Predictor of Poor Long-Term Survival in a Brazilian Stroke Cohort (Study of Stroke Mortality and Morbidity in Adults) EMMA study.
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de Mello, Roberta Ferreira, Santos, Itamar de Souza, Alencar, Airlane Pereira, Benseñor, Isabela Martins, Lotufo, Paulo Andrade, and Goulart, Alessandra Carvalho
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Background: The influence of poststroke depression on long-term survival is poorly investigated. Thus, we aimed to evaluate the influence of major depression disorder (MDD) on long-term survival in the participants from The Study of Stroke Mortality and Morbidity in Adults (EMMA Study) in São Paulo, Brazil.Methods: We prospectively evaluated ischemic and hemorrhagic stroke (HS) cases from the EMMA Study. Baseline and stroke characteristics and cardiovascular risk factors were evaluated according to MDD assessed by the Patient Health Questionnaire, which was applied 30 days after index event and periodically during 1-year follow-up. We performed Kaplan-Meier survival analysis, as well as crude and multiple Cox proportional hazards models.Results: In this subset of the EMMA Study, we evaluated 164 (85.9%) patients with ischemic stroke and 27 (14.1%) with HS. Among these, overall incidence of MDD was 25.1% during 1 year of follow-up, regardless stroke subtype. The peak rate of major depression postacute event was beyond 1 month. We observed a lower survival rate among individuals who developed poststroke MDD than among those who did not develop this condition after 1 year of follow-up (85.4% versus 96.5%, log rank P = .006). After multiple analysis, we kept a higher risk of all-cause mortality among those who developed MDD compared to participants without MDD (hazard ratio = 4.60, 95% confidence interval = 1.36-15.55, P = .01).Conclusion: Our findings suggest that incident MDD is a potential marker of poor prognosis 1 year after stroke. [ABSTRACT FROM AUTHOR]- Published
- 2016
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41. Stroke prevention within primary care: management of atrial fibrillation using oral anticoagulation.
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Lotufo, Paulo Andrade
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- 2018
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42. Launching the Latin American Epidemiological Cooperation relating to Noncommunicable Diseases.
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Lotufo, Paulo Andrade
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- 2018
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43. Keeping a watchful eye on the food giants and cleansing the temple of nutritional medicine and epidemiology.
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Lotufo, Paulo Andrade
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- 2018
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44. How to grade child health in Brazil? Comparison of the results from the Global Burden of Diseases 2015 in Latin America. A call for papers.
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Lotufo, Paulo Andrade
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- 2017
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45. Race and stroke mortality in Brazil.
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Lotufo, Paulo Andrade and Martins Bensenor, Isabela Judith
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As stroke mortality rates according to race were not known in Brazil, data on mortality for the year 2010 was collected from the Mortality Information System of the Brazilian Ministry of Health. Cerebrovascular mortality rates adjusted for age (per 100,000) were calculated with a confidence interval of 95% (95%CI) by sex and race/skin color. The differences between races were significant for men with rates of 44.4 (43.5;45.3), 48.2 (47.1;49.3) and 63.3 (60.6;66.6) for white, brown and black, respectively; and for women, with rates of 29.0 (28.3;29.7), 33.7 (32.8;34.6) and 51.0 (48.6;53.4) for white, brown and black, respectively. The burden of stroke mortality is higher among blacks compared to brown and white. [ABSTRACT FROM AUTHOR]
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- 2013
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46. Response of peripheral blood mononuclear cells to conditioned medium from cultured oral squamous cell carcinomas.
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França, Cristiane Miranda, Barros, Fabiana Mesquita, Lotufo, Monica Andrade, Santos Fernandes, Kristianne Porta, and Borra, Ricardo Carneiro
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SQUAMOUS cell carcinoma ,CYTOKINES ,PHYTOHEMAGGLUTININS ,ENDOTOXINS ,ENZYME-linked immunosorbent assay ,VASCULAR endothelial growth factors - Abstract
The current study investigated the capacity for tumor factors secreted by head and neck squamous cell carcinoma (HNSCC) cell lines, KB, KB16, and HEP, to induce the secretion of various cytokines from peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from blood samples collected from six healthy volunteers and these cells were incubated for 6, 24, 48, or 72 hours in the presence of 50% conditioned medium collected from cultured cell lines pretreated with, or without, stimulants such as phytohemagglutinin (PHA) or lipopolysaccharides (LPS). Aliquots of each supernatant were then assayed for levels of IFN-γ, vascular endothelial growth factor (VEGF), TNF-α, and IL-4 using enzyme linked immunosorbent assays (ELISAs). Data collected were analyzed using Student's t-test, an ANOVA test followed by Tukey's test, and tests of Pearson's Correlation. PBMCs cultured with KB16-conditioned medium produced the highest levels of IFN-γ. VEGF was also detected in conditioned media collected from all of the squamous cell carcinoma (SCC) cell lines used, and a significant difference in VEGF levels between control and KB- or KB16-conditioned media was observed. TNF-α was secreted by all PBMC groups within 6 hours of receiving conditioned media, and these levels increased up to the 24 hour timepoint, after which levels of TNF-α stabilized. In contrast, none of the supernatant samples contained detectable levels of IL-4. In combination, these data suggest that direct contact between fresh human PBMCs and conditioned media from tumor cells induces the secretion of TNF-α and VEGF by PBMCs, and this represents an initial angiogenic response. [ABSTRACT FROM AUTHOR]
- Published
- 2011
47. Application of the Spielberger's State-Trait Anger Expression Inventory in clinical patients.
- Author
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de Azevedo, Flávia Barros, Yuan-Pang Wang, Goulart, Alessandra Carvalho, Lotufo, Paulo Andrade, and Benseñor, Isabela Martins
- Abstract
Copyright of Arquivos de Neuro-Psiquiatria is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2010
- Full Text
- View/download PDF
48. Biotypes of Candida albicans isolates from the oral mucosa of HIV seropositive and control subjects.
- Author
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Noborikawa, Elisângela, da Silveira, Fernando Ricardo Xavier, Witzel, Andréa Lusvarghi, and Lotufo, Mônica Andrade
- Subjects
CANDIDA albicans ,ORAL mucosa diseases ,PROTEASE inhibitors ,HIV-positive persons ,HIV infections ,DENTURE complications ,ENZYME activation ,PROTEOLYTIC enzymes ,PHOSPHOLIPASES - Abstract
Copyright of Revista Odonto Ciencia is the property of EDIPUCRS - Editora Universitaria da PUCRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
49. A simple method to measure cell viability in proliferation and cytotoxicity assays.
- Author
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Borra, Ricardo Carneiro, Lotufo, Mônica Andrade, Gagioti, Sonia Maria, Barros, Fabiana de Mesquita, and Andrade, Priscila Maria
- Subjects
RESEARCH ,CELL proliferation ,RESAZURIN ,BIOCOMPATIBILITY ,BIOMEDICAL materials ,ELECTRONS ,SPECTROPHOTOMETERS ,COLORIMETRIC analysis ,FIBROBLASTS - Abstract
Resazurin dye has been broadly used as indicator of cell viability in several types of assays for evaluation of the biocompatibility of medical and dental materials. Mitochondrial enzymes, as carriers of diaphorase activities, are probably responsible for the transference of electrons from NADPH + H+ to resazurin, which is reduced to resorufin. The level of reduction can be quantified by spectrophotometers since resazurin exhibits an absorption peak at 600 ηm and resorufin at 570 ηm wavelengths. However, the requirement of a spectrophotometer and specific filters for the quantification could be a barrier to many laboratories. Digital cameras containing red, green and blue filters, which allow the capture of red (600 to 700 ηm) and green (500 to 600 ηm) light wavelengths in ranges bordering on resazurin and resorufin absorption bands, could be used as an alternative method for the assessment of resazurin and resorufin concentrations. Thus, our aim was to develop a simple, cheap and precise method based on a digital CCD camera to measure the reduction of resazurin. We compared the capability of the CCD-based method to distinguish different concentrations of L929 and normal Human buccal fibroblast cell lines with that of a conventional microplate reader. The correlation was analyzed through the Pearson coefficient. The results showed a strong association between the measurements of the method developed here and those made with the microplate reader (r² = 0.996; p < 0.01) and with the cellular concentrations (r² = 0.965; p < 0.01). We concluded that the developed Colorimetric Quantification System based on CCD Images allowed rapid assessment of the cultured cell concentrations with simple equipment at a reduced cost. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
50. Stroke is still a neglected disease in Brazil.
- Author
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Lotufo, Paulo Andrade
- Published
- 2015
- Full Text
- View/download PDF
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