190 results on '"Losi, Ma"'
Search Results
2. Current use of cardiac magnetic resonance in tertiary referral centres for the diagnosis of cardiomyopathy: the ESC EORP Cardiomyopathy/Myocarditis Registry
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Mizia-Stec K, Charron P, Gimeno Blanes JR, Elliott P, Kaski JP, Maggioni AP, Tavazzi L, Tendera M, Felix SB, Dominguez F, Ojrzynska N, Losi MA, Limongelli G, Barriales-Villa R, Seferovic PM, Biagini E, Wybraniec M, Laroche C, Caforio ALP, Mizia-Stec, K, Charron, P, Gimeno Blanes, Jr, Elliott, P, Kaski, Jp, Maggioni, Ap, Tavazzi, L, Tendera, M, Felix, Sb, Dominguez, F, Ojrzynska, N, Losi, Ma, Limongelli, G, Barriales-Villa, R, Seferovic, Pm, Biagini, E, Wybraniec, M, Laroche, C, and Caforio, Alp
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transthoracic echocardiography ,registry ,cardiomyopathy ,cardiac magnetic resonance - Abstract
ims: Cardiac magnetic resonance (CMR) is recommended in the diagnosis of cardiomyopathies, but it is time-consuming, expensive, and limited in availability in some European regions. The aim of this study was to determine the use of CMR in cardiomyopathy patients enrolled into the European Society of Cardiology (ESC) cardiomyopathy registry [part of the EURObservational Research Programme (EORP)]. Methods and results: Three thousand, two hundred, and eight consecutive adult patients (34.6% female; median age: 53.0 ± 15 years) with cardiomyopathy were studied: 1260 with dilated (DCM), 1739 with hypertrophic (HCM), 66 with restrictive (RCM), and 143 with arrhythmogenic right ventricular cardiomyopathy (ARVC). CMR scans were performed at baseline in only 29.4% of patients. CMR utilization was variable according to cardiomyopathy subtypes: from 51.1% in ARVC to 36.4% in RCM, 33.8% in HCM, and 20.6% in DCM (P < 0.001). CMR use in tertiary referral centres located in different European countries varied from 1% to 63.2%. Patients undergoing CMR were younger, less symptomatic, less frequently had implantable cardioverter-defibrillator (ICD)/pacemaker implanted, had fewer cardiovascular risk factors and comorbidities (P < 0.001). In 28.6% of patients, CMR was used along with transthoracic echocardiography (TTE); 67.6% patients underwent TTE alone, and 0.9% only CMR. Conclusion: Less than one-third of patients enrolled in the registry underwent CMR and the use varied greatly between cardiomyopathy subtypes, clinical profiles of patients, and European tertiary referral centres. This gap with current guidelines needs to be considered carefully by scientific societies to promote wider availability and use of CMR in patients with cardiomyopathies.
- Published
- 2021
3. P863Left ventricular apex level is the major determinant of twist mechanics magnitude
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Parisi, V, Losi, MA, Parrella, LS, Contaldi, C, Chiacchio, E, Caputi, A, Scatteia, A, Buonauro, A, and Betocchi, S
- Published
- 2011
4. [Transthoracic real-time three-dimensional echocardiography: clinical role, value and limitations in assessing heart valves]
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Agricola E, Badano LP, Mele D, Galderisi M, Spoladore R, Oppizzi M, Sciomer S, Nistri S, Ballo P, Buralli S, D'Andrea A, D'Errico A, Losi MA, Gardini C, Margonato A, Marino PN, Mondillo S., Agricola, E, Badano, Lp, Mele, D, Galderisi, Maurizio, Spoladore, R, Oppizzi, M, Sciomer, S, Nistri, S, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Losi, Ma, Gardini, C, Margonato, A, Marino, Pn, Mondillo, S., and Galderisi, M
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Heart Ventricles ,three-dimensional echocardiography ,ultrasound imaging ,echocardiography ,Echocardiography, Three-Dimensional ,Heart Valve Diseases ,Heart valve disease ,Sensitivity and Specificity ,Doppler echocardiography ,Three dimensional echocardiography ,Predictive Value of Tests ,Image Processing, Computer-Assisted ,Humans - Abstract
The introduction of three-dimensional echocardiography and its evolution from time-consuming and cumbersome off-line reconstruction to real-time volumetric technique (real-time three-dimensional echocardiography) are one of the most significant advances in ultrasound imaging of the heart of the past decade. This imaging modality currently provides realistic views of cardiac valves capable of demonstrating the anatomy of various heart valve diseases in a unique, noninvasive manner. In addition, real-time three-dimensional echocardiography offers completely new views of the valves and surrounding structures, and allows accurate quantification of severity of valve disease. This article reviews the advantages of real-time three-dimensional echocardiography in assessing heart valves and shows also technological limitations in order to provide the scientific basis for its clinical use.
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- 2010
5. Real-time multiplane echocardiography. Current applications, limits and perspective
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Mele D, Galderisi M, Badano L, Agricola E, Nistri S, Sciomer S, Ballo P, Buralli S, D'Andrea A, D'Errico A, Losi MA, Mondillo S., Mele, D, Galderisi, M, Badano, L, Agricola, E, Nistri, S, Sciomer, S, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Losi, Ma, and Mondillo, S.
- Published
- 2010
6. [Echocardiographic evaluation of the athlete's heart: from morphological adaptations to myocardial function]
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D'Andrea A, Galderisi M, Sciomer S, Nistri S, Agricola E, Ballo P, Buralli S, D'Errico A, Losi MA, Mele D, Mondillo S., D'Andrea, A, Galderisi, Maurizio, Sciomer, S, Nistri, S, Agricola, E, Ballo, P, Buralli, S, D'Errico, A, Losi, Ma, Mele, D, Mondillo, S., and Galderisi, M
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training ,training adaptation ,Myocardium ,Heart ,Myocardial Contraction ,Doppler echocardiography ,Echocardiography, Doppler, Color ,Echocardiography ,Predictive Value of Tests ,Heart Function Tests ,athlete's heart ,Humans ,Hypertrophy, Left Ventricular ,Athlete heart ,echocardiography ,Blood Flow Velocity ,Sports - Abstract
The definition of the athlete's heart includes the mechanisms of cardiac adaptation to training, characterized by the increase of internal chamber dimensions, ventricular wall thickness, and atrial chambers. The morphology of the athlete's heart is intermediate between concentric and eccentric left ventricular hypertrophy (LVH), in relation to the large prevalence of mixed sports activities and training protocols (including both aerobic and anaerobic exercise). Echocardiography is the tool of choice for the assessment of the athlete's heart and also for the differentiation of physiologic and pathologic LVH (hypertrophic cardiomyopathy and LVH due to arterial hypertension). The initial echocardiographic approach includes the quantitative analysis of the left ventricle, in order to calculate left ventricular mass, left ventricular mass index and relative wall thickness for diagnosing concentric or eccentric LVH. Tissue Doppler (pulsed or color modality) and strain rate imaging (Doppler or two-dimensional modality) may give additional information to the standard indices of systolic function. Diastolic function can be evaluated not only by standard Doppler transmitral inflow measurements but also using pulsed tissue Doppler, which may allow to distinguish the athlete's LVH from diastolic impairment of hypertensive patients or hypertrophic cardiomyopathy by the simple determination of myocardial early diastolic velocity. Also the morphological and functional features of the left atrium and of the right ventricle can be assessed in the athlete's heart by combining standard echocardiography with new echocardiographic technologies.
- Published
- 2009
7. Rapid Fire Abstract session: new insights in cardiomyopthies434The role of 4D echocardiography and cardiac biomarkers for early detection of chemotherapy induced cardiotoxicity in nonHodgkin lymphoma patients435Identification of proto-oncogenes and genes responsible for myocardial fibrosis and diastolic dysfunction after anticancer treatment under experimental conditions436Wild type transthyretin cardiac amyloidosis: clinical characteristics, echocardiographic findings, and predictors of outcome437A novel echocardiographic index for detection of cardiac amyloidosis.438Left ventricular outflow obstruction is a treatable feature rather than a risk marker in patients with hypertrophic cardiomyopathy439The international stress echo registry in hypertrophic cardiomyopathy440Value of left atrial size and function to risk stratify for new onset atrial fibrillation in hypertrophic cardiomyopathy441Right ventricle ejection fraction by cardiac resonance imaging is superior in discrimination between early phase ARVC and right ventricular outflow tract ventricular tachycardia
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Mihalcea, D, primary, Bergler-Klein, J, primary, Grogan, M, primary, Pagourelias, E, primary, Faber, L, primary, Ciampi, Q, primary, Debonnaire, P, primary, Saberniak, J, primary, Florescu, M, additional, Vladareanu, AM, additional, Mihaila, S, additional, Vinereanu, D, additional, Spannbauer, A, additional, Zlabinger, K, additional, Macejovska, D, additional, Maurer, G, additional, Gyongyosi, M, additional, Scott, C, additional, Lin, G, additional, Klarich, K, additional, Miller, W, additional, Dispenzieri, A, additional, Mirea, OC, additional, Duchenne, J, additional, Vovas, G, additional, Van Aelst, L, additional, Claus, P, additional, Van Cleemput, J, additional, Delforge, M, additional, Bogaert, J, additional, Voigt, JU, additional, Burghardt, A, additional, Seggewiss, H, additional, Van Buuren, F, additional, Horstkotte, D, additional, Olivotto, I, additional, Gardini, C, additional, Monserrat, L, additional, Peteiro, J, additional, Lopes, L, additional, Cotrim, C, additional, Losi, MA, additional, Lazzeroni, DE, additional, Picano, E, additional, Joyce, E, additional, Van Den Brink, OVW, additional, Bax, JJ, additional, Delgado, V, additional, Ajmone Marsan, N, additional, Leren, IS, additional, Haland, TF, additional, Hopp, E, additional, Edvardsen, T, additional, and Haugaa, KH, additional
- Published
- 2015
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8. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy
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MARON MS, OLIVOTTO J, CASEY SA, LESSER JR, LOSI MA, CECCHI F, MARON BJ, BETOCCHI, SANDRO, Maron, M, Olivotto, J, Betocchi, Sandro, Casey, Sa, Lesser, Jr, Losi, Ma, Cecchi, F, and Maron, Bj
- Published
- 2003
9. Special problems in the surgically treated valve disease patient
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BETOCCHI, SANDRO, LOSI MA, CHIARIELLO M., CRAWFORD MH, DI MARCO JP, Betocchi, Sandro, Losi, Ma, and Chiariello, M.
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- 2000
10. Determinants of aortic artifacts during transesophageal echocardiography of the ascending aorta
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LOSI MA, BETOCCHI S, BRIGUORI C., MANGANELLI F., SPAMPINATO, NICOLA, Losi, Ma, Betocchi, S, Briguori, C., Manganelli, F., and Spampinato, Nicola
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- 1999
11. Peptide natriuretico di tipo B ed ecocardiografia Doppler nella diagnosi di scompenso cardiaco: Metodiche alternative o complementari? [B-type natriuretic peptide and Doppler echocardiography in the diagnosis of heart failure: alternative or complementary tools?]
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Palazzuoli, Alberto, Galderisi, M, Gallotta, Maddalena, Sciomer, S, Nistri, S, Agricola, E, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Losi, Ma, Mele, D, Mondillo, Sergio, and Nuti, Ranuccio
- Published
- 2009
12. Ecocardiografia tridimensionale in tempo reale. Attuali applicazioni, vantaggi e limiti per lo studio del ventricolo sinistro [Real-time three-dimensional echocardiography: current applications, advantages and limits for the evaluation of the left ventricle]
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Mele, D, Agricola, E, Galderisi, M, Sciomer, S, Nistri, S, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Losi, Ma, and Mondillo, Sergio
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Echocardiography ,Real-time three-dimensional echocardiography - Published
- 2009
13. Real-time three dimensional echocardiography: current applications, advantages and limits for the evaluation of the left ventricle
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Mele, D, Agricola, E, Galderisi, M, Sciomer, Susanna, Nistri, S, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Losi, Ma, Mondillo, S, and GRUPPO DI STUDIO DI ECOCARDIOGRAFIA DELLA SOCIETÀ ITALIANA DI CARDIOLOGIA
- Published
- 2009
14. Recombinant tissue-type plasminogen activator therapy in prosthetic mitral valve thrombosis: assessment by transthoracic and transesophageal echocardiography
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LOSI MA, BETOCCHI S, BRIGUORI C, MANGANELLI F, SPAMPINATO, NICOLA, Losi, Ma, Betocchi, S, Briguori, C, Manganelli, F, and Spampinato, Nicola
- Published
- 1995
15. Analisi dell'ispessimento di parete regionale in cardiomiopatia ipertrofica: valutazione con scintigrafia perfusionale tomografica gated con 99mtecnezio-sestamibi
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Boccalatte M, Betocchi S, Pace L, Franculli F, Squame F, Soricelli A, Losi MA, Salvatore M, Chiariello M., PERRONE FILARDI, PASQUALE, Boccalatte, M, Betocchi, S, Pace, L, Franculli, F, Squame, F, Soricelli, A, Losi, Ma, PERRONE FILARDI, Pasquale, Salvatore, M, and Chiariello, M.
- Published
- 1994
16. Effects of atrio ventricular pacing on obstruction and on diastolic function in hypertrophic cardiomyopathy
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Betocchi S, Losi MA, Piscione F, Pace L, Boccalatte M, Salvatore M, Chiariello M., PERRONE FILARDI, PASQUALE, Betocchi, S, Losi, Ma, Piscione, F, PERRONE FILARDI, Pasquale, Pace, L, Boccalatte, M, Salvatore, M, and Chiariello, M.
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- 1994
17. Atrio-ventricular pacing relieves obstruction but impairs diastolic function in hypertrophic cardiomyopathy
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Betocchi S, Losi MA, Piscione F, Russolillo E, Pace L, Boccalatte M, Salvatore M, Chiariello M., PERRONE FILARDI, PASQUALE, Betocchi, S, Losi, Ma, Piscione, F, Russolillo, E, PERRONE FILARDI, Pasquale, Pace, L, Boccalatte, M, Salvatore, M, and Chiariello, M.
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- 1994
18. Impatto della distribuzione dell'ipertrofia ventricolare sinistra sulla meccanica diastolica in cardiomiopatia ipertrofica
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Franculli F, Betocchi S, Losi MA, Boccalatte M, Pace L, Piscione F, Golino P, Briguori C, Salvatore M, Chiariello M., PERRONE FILARDI, PASQUALE, Franculli, F, Betocchi, S, Losi, Ma, Boccalatte, M, Pace, L, Piscione, F, Golino, P, PERRONE FILARDI, Pasquale, Briguori, C, Salvatore, M, and Chiariello, M.
- Published
- 1994
19. Progressione della velocità di riempimento rapido nel ventricolo sinistro in cardiomiopatia ipertrofica
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Losi MA, Betocchi S, Manganelli F, Salvatore C, Franculli F, Pace L, Salvatore M, Chiariello M., PERRONE FILARDI, PASQUALE, Losi, Ma, Betocchi, S, Manganelli, F, Salvatore, C, Franculli, F, Pace, L, PERRONE FILARDI, Pasquale, Salvatore, M, and Chiariello, M.
- Published
- 1993
20. Dual chamber pacing in hypertrophic cardiomyopathy: impact of atrio ventricular coupling on left ventricular obstruction
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Betocchi S, Losi MA, Franculli F, Russolillo E, Piscione F., PERRONE FILARDI, PASQUALE, Betocchi, S, Losi, Ma, Franculli, F, PERRONE FILARDI, Pasquale, Russolillo, E, and Piscione, F.
- Published
- 1993
21. Persistenza di alterazioni della contrattilità regionale dopo test ergometrico. in assenza di alterazioni della perfusione miocardica. Evidenza clinica del fenomeno del 'miocardio stordito' in pazienti coronaropatici
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Ambrosio G, Losi MA, Betocchi S, Pace L, Soricelli A, Squame F, Menna M, Salvatore M, Chiariello M, Weiss JL, PERRONE FILARDI, PASQUALE, Ambrosio, G, Losi, Ma, PERRONE FILARDI, Pasquale, Betocchi, S, Pace, L, Soricelli, A, Squame, F, Menna, M, Salvatore, M, Chiariello, M, and Weiss, Jl
- Published
- 1993
22. Noninvasive evaluation of leftventricular diastolic function in hypertrophic cardiomyopathy
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Briguori, C, Betocchi, S, Losi, Ma, Manganelli, F, Piscione, Federico, Pace, L, Boccalatte, M, Gottilla, R, Salvatore, M, and Chiariello, M.
- Published
- 1998
23. Prolongedimpairment of regional contractile function after resolution of exercise-induced angina. Evidence of myocardial stunning in patients with coronary artery disease
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Ambrosio, G, Betocchi, S, Pace, L, Losi, Ma, Perrone Filardi, P, Soricelli, A, Piscione, Federico, Taube, J, Squame, F, Salvatore, M, Weiss, Jl, and Chiariello, M.
- Published
- 1996
24. Effects of dual-chamber pacing in hypertrophic cardiomyopathy on left ventricularoutflow tract obstruction and on diastolic function
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Betocchi, S, Losi, Ma, Piscione, Federico, Boccalatte, M, Pace, L, Golino, P, Perrone Filardi, P, Briguori, C, Franculli, F, Pappone, C, Salvatore, M, and Chiariello, M.
- Published
- 1996
25. ATRIOVENTRICULAR PACING RELIEVES OBSTRUCTION BUT IMPAIRS DIASTOLIC FUNCTIONS IN HYPERTROPHIC CARDIOMYOPATHY
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Betocchi, S, Losi, Ma, Piscione, Federico, Russolillo, E, Perronefilardi, P, Pace, Leonardo, Boccalatte, M, Salvatore, M, and Chiariello, M.
- Published
- 1994
26. PERSISTENCE OF CONTRACTILE IMPAIRMENT IN THE ABSENCE OF FLOW ABNORMALITIES AFTER EXERCISE - EVIDENCE FOR MYOCARDIAL STUNNING IN PATIENTS WITH STABLE ANGINA
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Ambrosio, G, Losi, Ma, Perronefilardi, P, Betocchi, S, Pace, Leonardo, Soricelli, A, Piscione, Federico, Salvatore, M, Chiariello, M, and Weiss, Jl
- Published
- 1993
27. HEMODYNAMIC-EFFECTS OF DILTIAZEM IN HYPERTROPHIC CARDIOMYOPATHY
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Betocchi, S, Losi, Ma, Piscione, Federico, Cappellibigazzi, M, Pace, Leonardo, Grimaldi, M, Salvatore, M, and Chiariello, M.
- Published
- 1992
28. Development and Usability of a Novel Interactive Tablet App (PediAppRREST) to Support the Management of Pediatric Cardiac Arrest: Pilot High-Fidelity Simulation-Based Study
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Corazza, Francesco, Snijders, Deborah, Arpone, Marta, Stritoni, Valentina, Martinolli, Francesco, Daverio, Marco, Losi, Maria Giulia, Soldi, Luca, Tesauri, Francesco, Da Dalt, Liviana, and Bressan, Silvia
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Information technology ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPediatric cardiac arrest (PCA), although rare, is associated with high mortality. Deviations from international management guidelines are frequent and associated with poorer outcomes. Different strategies/devices have been developed to improve the management of cardiac arrest, including cognitive aids. However, there is very limited experience on the usefulness of interactive cognitive aids in the format of an app in PCA. No app has so far been tested for its usability and effectiveness in guiding the management of PCA. ObjectiveTo develop a new audiovisual interactive app for tablets, named PediAppRREST, to support the management of PCA and to test its usability in a high-fidelity simulation-based setting. MethodsA research team at the University of Padova (Italy) and human–machine interface designers, as well as app developers, from an Italian company (RE:Lab S.r.l.) developed the app between March and October 2019, by applying an iterative design approach (ie, design–prototyping–evaluation iterative loops). In October–November 2019, a single-center nonrandomized controlled simulation–based pilot study was conducted including 48 pediatric residents divided into teams of 3. The same nonshockable PCA scenario was managed by 11 teams with and 5 without the app. The app user’s experience and interaction patterns were documented through video recording of scenarios, debriefing sessions, and questionnaires. App usability was evaluated with the User Experience Questionnaire (UEQ) (scores range from –3 to +3 for each scale) and open-ended questions, whereas participants’ workload was measured using the NASA Raw-Task Load Index (NASA RTLX). ResultsUsers’ difficulties in interacting with the app during the simulations were identified using a structured framework. The app usability, in terms of mean UEQ scores, was as follows: attractiveness 1.71 (SD 1.43), perspicuity 1.75 (SD 0.88), efficiency 1.93 (SD 0.93), dependability 1.57 (SD 1.10), stimulation 1.60 (SD 1.33), and novelty 2.21 (SD 0.74). Team leaders’ perceived workload was comparable (P=.57) between the 2 groups; median NASA RTLX score was 67.5 (interquartile range [IQR] 65.0-81.7) for the control group and 66.7 (IQR 54.2-76.7) for the intervention group. A preliminary evaluation of the effectiveness of the app in reducing deviations from guidelines showed that median time to epinephrine administration was significantly longer in the group that used the app compared with the control group (254 seconds versus 165 seconds; P=.015). ConclusionsThe PediAppRREST app received a good usability evaluation and did not appear to increase team leaders’ workload. Based on the feedback collected from the participants and the preliminary results of the evaluation of its effects on the management of the simulated scenario, the app has been further refined. The effectiveness of the new version of the app in reducing deviations from guidelines recommendations in the management of PCA and its impact on time to critical actions will be evaluated in an upcoming multicenter simulation-based randomized controlled trial.
- Published
- 2020
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29. Myocardial collagen turnover in hypertrophic cardiomyopathy.
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Lombardi R, Betocchi S, Losi MA, Tocchetti CG, Aversa M, Miranda M, D'Alessandro G, Cacace A, Ciampi Q, Chiariello M, Lombardi, Raffaella, Betocchi, Sandro, Losi, Maria Angela, Tocchetti, Carlo Gabriele, Aversa, Mariano, Miranda, Marianna, D'Alessandro, Gianluigi, Cacace, Alessandra, Ciampi, Quirino, and Chiariello, Massimo
- Published
- 2003
30. Aortic valve sclerosis: new help from echocardiography in the assessment of cardiovascular risk.
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Muiesan ML, Losi MA, Muiesan, Maria Lorenza, and Losi, Maria Angela
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- 2005
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31. Prolonged impairment of regional contractile function after resolution of exercise-induced angina - Evidence of myocardial stunning in patients with coronary artery disease
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Ambrosio, G., Betocchi, S., Pace, L., Losi, Ma, Perronefilardi, P., Andrea Soricelli, Piscione, F., Taube, J., Squame, F., Salvatore, M., Weiss, Jl, Chiariello, M., Ambrosio, G, Betocchi, S, Pace, Leonardo, Losi, Ma, Perronefilardi, P, Soricelli, A, Piscione, F, Taube, J, Squame, F, Salvatore, M, Weiss, Jl, and Chiariello, M.
32. Interstitial collagen turnover affects passive diastolic function in hypertrophic cardiomyopathy
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Tocchetti, Cg, Lombardi, R., Losi, Ma, Ciampi, Q., Pezzella, E., Finizio, F., Crescenzo, V., Manganelli, F., Pasquale Vergara, and Betocchi, S.
33. Thrombosis of mechanical valve prosthesis in patient with recent Caesarean delivery.
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Pastore F, Losi MA, Carpinella G, Cavallaro M, Fundaliotis A, Chiacchio E, Betocchi S, and Chiariello M
- Published
- 2009
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34. Rapid Fire Abstract session: new insights in cardiomyopthies
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Mihalcea, D, Florescu, M, Vladareanu, AM, Mihaila, S, Vinereanu, D, Bergler-Klein, J, Spannbauer, A, Zlabinger, K, Macejovska, D, Maurer, G, Gyongyosi, M, Grogan, M, Scott, C, Lin, G, Klarich, K, Miller, W, Dispenzieri, A, Pagourelias, E, Mirea, OC, Duchenne, J, Vovas, G, Van Aelst, L, Claus, P, Van Cleemput, J, Delforge, M, Bogaert, J, Voigt, JU, Faber, L, Burghardt, A, Seggewiss, H, Van Buuren, F, Horstkotte, D, Ciampi, Q, Olivotto, I, Gardini, C, Monserrat, L, Peteiro, J, Lopes, L, Cotrim, C, Losi, MA, Lazzeroni, DE, Picano, E, Debonnaire, P, Joyce, E, Van Den Brink, OVW, Bax, JJ, Delgado, V, Ajmone Marsan, N, Saberniak, J, Leren, IS, Haland, TF, Hopp, E, Edvardsen, T, and Haugaa, KH
- Abstract
CHOP regimen is standard chemotherapy in patients with non-Hodgkin's lymphoma (NHL), but its use is limited by the risk of cardiotoxicity. Aim. To define new parameters, such as 4D echo (4DE) LV deformation or biomarkers, to diagnose early cardiac dysfunction and predict cardiotoxicity. Methods. 37 patients (13 men, 62 ± 12 years) with NHL, without cardiac disease, with EF>53%, scheduled to receive CHOP, were assessed at baseline, after the 2nd and 4th cycle. 4DE was used to assess EF and LV systolic deformation: longitudinal, radial, circumferential, area strain (LS, RS, CS, AS). Troponin I was measured. Cardiotoxicity was defined as a decrease of EF <53%, with >10% from the baseline. Results. After the 4th cycle of CHOP, 10 patients (27%) (group I) developed cardiotoxicity, while 27 patients (group II) didn't. There was a significant reduction of all LV systolic deformation parameters starting with the 2nd cycle, but group I had lower values than group II (Table). The reduction of the LS after the 2nd cycle was the best independent predictor for the decrease of EF after the 4th cycle (R2=0.44, p=0.0001); a decrease of LS with >30% after the 2nd cycle predicted the development of cardiotoxicity after the 4th cycle (sb 100%, sp 85%). Conclusion. Assessment of 4DE myocardial deformation parameters are able to detect early chemotherapy-induced cardiotoxicity and to predict further changes in the EF of patients with NHL.
4D deformation parameters CHOP Group I Group II p value (Anova) LS (-%) Baseline 22 ± 2 22 ± 2 0.0001 2nd cycle 10 ± 1 16 ± 2* 0.0001 4th cycle 8 ± 1* 12 ± 2* 0.0001 CS (-%) Baseline 21 ± 2* 21 ± 2* 0.0001 2nd cycle 15 ± 1* 17 ± 2* 0.05 4th cycle 12 ± 3* 15 ± 1* 0.0001 RS (%) Baseline 56 ± 5* 56 ± 5* 0.0001 2nd cycle 40 ± 5* 46 ± 6* 0.05 4th cycle 33 ± 6* 39 ± 6* 0.0001 AS(%) Baseline 35 ± 4* 36 ± 4* 0.0001 2nd cycle 22 ± 5 28 ± 4* 0.0001 4th cycle 17 ± 5* 23 ± 4 0.01 - Published
- 2015
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35. Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry
- Author
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Lopes, Luis R, Losi, Maria-Angela, Sheikh, Nabeel, Laroche, Cécile, Charron, Philippe, Gimeno, Juan, Kaski, Juan P, Maggioni, Aldo P, Tavazzi, Luigi, Arbustini, Eloisa, Brito, Dulce, Celutkiene, Jelena, Hagege, Albert, Linhart, Ales, Mogensen, Jens, Garcia-Pinilla, José Manuel, Ripoll-Vera, Tomas, Seggewiss, Hubert, Villacorta, Eduardo, Caforio, Alida, Elliott, Perry M, Komissarova, S, Chakova, N, Niyazova, S, Linhart, A, Kuchynka, P, Palecek, T, Podzimkova, J, Fikrle, M, Nemecek, E, Bundgaard, H, Tfelt-Hansen, J, Theilade, J, Thune, J J, Axelsson, A, Mogensen, J, Henriksen, F, Hey, T, Nielsen, S K, Videbaek, L, Andreasen, S, Arnsted, H, Saad, A, Ali, M, Lommi, J, Helio, T, Nieminen, M S, Dubourg, O, Mansencal, N, Arslan, M, Tsieu, V Siam, Damy, T, Guellich, A, Guendouz, S, Tissot, C M, Lamine, A, Rappeneau, S, Hagege, A, Desnos, M, Bachet, A, Hamzaoui, M, Charron, P, Isnard, R, Legrand, L, Maupain, C, Gandjbakhch, E, Kerneis, M, Pruny, J-F, Bauer, A, Pfeiffer, B, Felix, S B, Dorr, M, Kaczmarek, S, Lehnert, K, Pedersen, A-L, Beug, D, Bruder, M, Böhm, M, Kindermann, I, Linicus, Y, Werner, C, Neurath, B, Schild-Ungerbuehler, M, Seggewiss, H, Neugebauer, A, Mckeown, P, Muir, A, Mcosker, J, Jardine, T, Divine, G, Elliott, P, Lorenzini, M, Watkinson, O, Wicks, E, Iqbal, H, Mohiddin, S, O'Mahony, C, Sekri, N, Carr-White, G, Bueser, T, Rajani, R, Clack, L, Damm, J, Jones, S, Sanchez-Vidal, R, Smith, M, Walters, T, Wilson, K, Rosmini, S, Anastasakis, A, Ritsatos, K, Vlagkouli, V, Forster, T, Sepp, R, Borbas, J, Nagy, V, Tringer, A, Kakonyi, K, Szabo, L A, Maleki, M, Bezanjani, F Noohi, Amin, A, Naderi, N, Parsaee, M, Taghavi, S, Ghadrdoost, B, Jafari, S, Khoshavi, M, Rapezzi, C, Biagini, E, Corsini, A, Gagliardi, C, Graziosi, M, Longhi, S, Milandri, A, Ragni, L, Palmieri, S, Olivotto, I, Arretini, A, Castelli, G, Cecchi, F, Fornaro, A, Tomberli, B, Spirito, P, Devoto, E, Bella, P Della, Maccabelli, G, Sala, S, Guarracini, F, Peretto, G, Russo, M G, Calabro, R, Pacileo, G, Limongelli, G, Masarone, D, Pazzanese, V, Rea, A, Rubino, M, Tramonte, S, Valente, F, Caiazza, M, Cirillo, A, Del Giorno, G, Esposito, A, Gravino, R, Marrazzo, T, Trimarco, B, Losi, M-A, Nardo, C Di, Giamundo, A, Musella, F, Pacelli, F, Scatteia, A, Canciello, G, Caforio, A, Iliceto, S, Calore, C, Leoni, L, Marra, M Perazzolo, Rigato, I, Tarantini, G, Schiavo, A, Testolina, M, Arbustini, E, Toro, A Di, Giuliani, L P, Serio, A, Fedele, F, Frustaci, A, Alfarano, M, Chimenti, C, Drago, F, Baban, A, Calò, L, Lanzillo, C, Martino, A, Uguccioni, M, Zachara, E, Halasz, G, Re, F, Sinagra, G, Carriere, C, Merlo, M, Ramani, F, Kavoliuniene, A, Krivickiene, A, Tamuleviciute-Prasciene, E, Viezelis, M, Celutkiene, J, Balkeviciene, L, Laukyte, M, Paleviciute, E, Pinto, Y, Wilde, A, Asselbergs, F W, Sammani, A, Van Der Heijden, J, Van Laake, L, De Jonge, N, Hassink, R, Kirkels, J H, Ajuluchukwu, J, Olusegun-Joseph, A, Ekure, E, Mizia-Stec, K, Tendera, M, Czekaj, A, Sikora-Puz, A, Skoczynska, A, Wybraniec, M, Rubis, P, Dziewiecka, E, Wisniowska-Smialek, S, Bilinska, Z, Chmielewski, P, Nieradko, B Foss, Michalak, E, Stepien-Wojno, M, Mazek, B, Lopes, L Rocha, Almeida, A R, Cruz, I, Gomes, A C, Pereira, A R, Brito, D, Madeira, H, Francisco, A R, Menezes, M, Moldovan, O, Guimaraes, T Oliveira, Silva, D, Ginghina, C, Jurcut, R, Mursa, A, Popescu, B A, Apetrei, E, Militaru, S, Coman, I Mircea, Frigy, A, Fogarasi, Z, Kocsis, I, Szabo, I A, Fehervari, L, Nikitin, I, Resnik, E, Komissarova, M, Lazarev, V, Shebzukhova, M, Ustyuzhanin, D, Blagova, O, Alieva, I, Kulikova, V, Lutokhina, Y, Pavlenko, E, Varionchik, N, Ristic, A D, Seferovic, P M, Veljic, I, Zivkovic, I, Milinkovic, I, Pavlovic, A, Radovanovic, G, Simeunovic, D, Zdravkovic, M, Aleksic, M, Djokic, J, Hinic, S, Klasnja, S, Mircetic, K, Monserrat, L, Fernandez, X, Garcia-Giustiniani, D, Larrañaga, J M, Ortiz-Genga, M, Barriales-Villa, R, Martinez-Veira, C, Veira, E, Cequier, A, Salazar-Mendiguchia, J, Manito, N, Gonzalez, J, Fernández-Avilés, F, Medrano, C, Yotti, R, Cuenca, S, Espinosa, M A, Mendez, I, Zatarain, E, Alvarez, R, Pavia, P Garcia, Briceno, A, Cobo-Marcos, M, Dominguez, F, Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N, Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A, Gomez-Garcia, D, Robles-Mezcua, M, Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, Ripoll-Vera, T, Alvarez, J, Nunez, J, Gomez, Y, Fernandez, P L Sanchez, Villacorta, E, Avila, C, Bravo, L, Diaz-Pelaez, E, Gallego-Delgado, M, Garcia-Cuenllas, L, Plata, B, Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E, Arnau, M A, Sanz, J, Marques-Sule, E, Gale, Christopher Peter, Beleslin, Branko, Budaj, Andrzej, Chioncel, Ovidiu, Dagres, Nikolaos, Danchin, Nicolas, Erlinge, David, Emberson, Jonathan, Glikson, Michael, Gray, Alastair, Kayikcioglu, Meral, Maggioni, Aldo, Nagy, Klaudia Vivien, Nedoshivin, Aleksandr, Petronio, Anna-Sonia, Hesselink, Jolien Roo, Wallentin, Lars, Zeymer, Uwe, Caforio, Alida, Blanes, Juan Ramon Gimeno, Charron, Philippe, Elliott, Perry, Kaski, Juan Pablo, Maggioni, Aldo P, Tavazzi, Luigi, Tendera, Michal, Komissarova, S., Chakova, N., Niyazova, S., Linhart, A., Kuchynka, P., Palecek, T., Podzimkova, J., Fikrle, M., Nemecek, E., Bundgaard, H., Tfelt-Hansen, J., Theilade, J., Thune, J J, Axelsson, A., Mogensen, J., Henriksen, F., Hey, T., Nielsen, S K, Videbaek, L., Andreasen, S., Arnsted, H., Saad, A., Ali, M., Lommi, J., Helio, T., Nieminen, M S, Dubourg, O., Mansencal, N., Arslan, M., Tsieu, V Siam, Damy, T., Guellich, A., Guendouz, S., Tissot, C M, Lamine, A., Rappeneau, S., Hagege, A., Desnos, M., Bachet, A., Hamzaoui, M., Charron, P., Isnard, R., Legrand, L., Maupain, C., Gandjbakhch, E., Kerneis, M., Pruny, J-F, Bauer, A., Pfeiffer, B., Felix, S B, Dorr, M., Kaczmarek, S., Lehnert, K., Pedersen, A-L, Beug, D., Bruder, M., Böhm, M., Kindermann, I., Linicus, Y., Werner, C., Neurath, B., Schild-Ungerbuehler, M., Seggewiss, H., Neugebauer, A., McKeown, P., Muir, A., McOsker, J., Jardine, T., Divine, G., Elliott, P., Lorenzini, M., Watkinson, O., Wicks, E., Iqbal, H., Mohiddin, S., O'Mahony, C., Sekri, N., Carr-White, G., Bueser, T., Rajani, R., Clack, L., Damm, J., Jones, S., Sanchez-Vidal, R., Smith, M., Walters, T., Wilson, K., Rosmini, S., Anastasakis, A., Ritsatos, K., Vlagkouli, V., Forster, T., Sepp, R., Borbas, J., Nagy, V., Tringer, A., Kakonyi, K., Szabo, L A, Maleki, M., Bezanjani, F Noohi, Amin, A., Naderi, N., Parsaee, M., Taghavi, S., Ghadrdoost, B., Jafari, S., Khoshavi, M., Rapezzi, C., Biagini, E., Corsini, A., Gagliardi, C., Graziosi, M., Longhi, S., Milandri, A., Ragni, L., Palmieri, S., Olivotto, I., Arretini, A., Castelli, G., Cecchi, F., Fornaro, A., Tomberli, B., Spirito, P., Devoto, E., Bella, P Della, Maccabelli, G., Sala, S., Guarracini, F., Peretto, G., Russo, M G, Calabro, R., Pacileo, G., Limongelli, G., Masarone, D., Pazzanese, V., Rea, A., Rubino, M., Tramonte, S., Valente, F., Caiazza, M., Cirillo, A., Del Giorno, G., Esposito, A., Gravino, R., Marrazzo, T., Trimarco, B., Losi, M-A, Di Nardo, C., Giamundo, A., Musella, F., Pacelli, F., Scatteia, A., Canciello, G., Caforio, A., Iliceto, S., Calore, C., Leoni, L., Marra, M Perazzolo, Rigato, I., Tarantini, G., Schiavo, A., Testolina, M., Arbustini, E., Di Toro, A., Giuliani, L P, Serio, A., Fedele, F., Frustaci, A., Alfarano, M., Chimenti, C., Drago, F., Baban, A., Calò, L., Lanzillo, C., Martino, A., Uguccioni, M., Zachara, E., Halasz, G., Re, F., Sinagra, G., Carriere, C., Merlo, M., Ramani, F., Kavoliūnienė, Aušra, Krivickienė, Aušra, Tamulevičiūtė-Prascienė, Eglė, Vieželis, Mindaugas, Balkevičienė, Laura, Laukytė, M., Palevičiūtė, Eglė, Pinto, Y., Wilde, A., Asselbergs, F W, Sammani, A., Van Der Heijden, J., Van Laake, L., De Jonge, N., Hassink, R., Kirkels, J H, Ajuluchukwu, J., Olusegun-Joseph, A., Ekure, E., Mizia-Stec, K., Tendera, M., Czekaj, A., Sikora-Puz, A., Skoczynska, A., Wybraniec, M., Rubis, P., Dziewiecka, E., Wisniowska-Smialek, S., Bilinska, Z., Chmielewski, P., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Mazek, B., Lopes, L Rocha, Almeida, A R, Cruz, I., Gomes, A C, Pereira, A R, Brito, D., Madeira, H., Francisco, A R, Menezes, M., Moldovan, O., Guimaraes, T Oliveira, Silva, D., Ginghina, C., Jurcut, R., Mursa, A., Popescu, B A, Apetrei, E., Militaru, S., Coman, I Mircea, Frigy, A., Fogarasi, Z., Kocsis, I., Szabo, I A, Fehervari, L., Nikitin, I., Resnik, E., Komissarova, M., Lazarev, V., Shebzukhova, M., Ustyuzhanin, D., Blagova, O., Alieva, I., Kulikova, V., Lutokhina, Y., Pavlenko, E., Varionchik, N., Ristic, A D, Seferovic, P M, Veljic, I., Zivkovic, I., Milinkovic, I., Pavlovic, A., Radovanovic, G., Simeunovic, D., Zdravkovic, M., Aleksic, M., Djokic, J., Hinic, S., Klasnja, S., Mircetic, K., Monserrat, L., Fernandez, X., Garcia-Giustiniani, D., Larrañaga, J M, Ortiz-Genga, M., Barriales-Villa, R., Martinez-Veira, C., Veira, E., Cequier, A., Salazar-Mendiguchia, J., Manito, N., Gonzalez, J., Fernández-Avilés, F., Medrano, C., Yotti, R., Cuenca, S., Espinosa, M A, Mendez, I., Zatarain, E., Alvarez, R., Pavia, P Garcia, Briceno, A., Cobo-Marcos, M., Dominguez, F., Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N., Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A., Gomez-Garcia, D., Robles-Mezcua, M., Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, de Mallorca, Palma, Ripoll-Vera, T., Alvarez, J., Nunez, J., Gomez, Y., Fernandez, P L Sanchez, Villacorta, E., Avila, C., Bravo, L., Diaz-Pelaez, E., Gallego-Delgado, M., Garcia-Cuenllas, L., Plata, B., Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E., Arnau, M A, Sanz, J., Marques-Sule, E., Repositório da Universidade de Lisboa, Lopes, Lr, Losi, Ma, Sheikh, N, Laroche, C, Charron, P, Gimeno, J, Kaski, Jp, Maggioni, Ap, Tavazzi, L, Arbustini, E, Brito, D, Celutkiene, J, Hagege, A, Linhart, A, Mogensen, J, Garcia-Pinilla, Jm, Ripoll-Vera, T, Seggewiss, H, Villacorta, E, Caforio, A, and Elliott, Pm
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Genotype ,Health Policy ,Diabetes ,Cardiovascular risk factors ,Hypertension ,Hypertrophic cardiomyopathy ,Obesity ,Cardiomyopathy, Hypertrophic ,Ventricular Dysfunction, Left ,diabete ,Cardiovascular Diseases ,Risk Factors ,Heart Disease Risk Factors ,cardiovascular risk factor ,Humans ,Female ,03.02. Klinikai orvostan ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies ,obesity - Abstract
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited., Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI) and clinical traits was analyzed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene.The prevalence of HT, DM and obesity (Ob) was 37%, 10%, and 21%, respectively. HT, DM and Ob were associated with older age (p
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- 2022
36. The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporary management of adult patients with cardiomyopathies
- Author
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Charron, Philippe, Elliott, Perry M, Gimeno, Juan R, Caforio, Alida L P, Kaski, Juan Pablo, Tavazzi, Luigi, Tendera, Michal, Maupain, Carole, Laroche, Cécile, Rubis, Pawel, Jurcut, Ruxandra, Calò, Leonardo, Heliö, Tiina M, Sinagra, Gianfranco, Zdravkovic, Marija, Kavoliūnienė, Aušra, Felix, Stephan B, Grzybowski, Jacek, Losi, Maria-Angela, Asselbergs, Folkert W, García-Pinilla, José Manuel, Salazar-Mendiguchia, Joel, Mizia-Stec, Katarzyna, Maggioni, Aldo P, Anastasakis, Aris, Biagini, Elena, Bilinska, Zofia, Castro, Francisco Jose, Celutkiene, Jelena, Chakova, Natalija, Chmielewski, Przemyslaw, Drago, Fabrizio, Frigy, Attila, Frustaci, Andrea, Garcia-Pavia, Pablo, Hinic, Sasa, Kindermann, Ingrid, Limongelli, Giuseppe, Medrano, Constancio, Monserrat, Lorenzo, Olusegun-Joseph, Akinsanya, Ripoll-Vera, Tomas, Rocha Lopes, Luis, Saad, Aly, Sala, Simone, Seferovic, Petar M, Sepp, Robert, Urbano-Moral, Jose Angel, Villacorta, Eduardo, Wybraniec, Maciej, Yotti, Raquel, Zachara, Elisabetta, Zorio, Esther, Charron, P., Elliott, P. M., Gimeno, J. R., Caforio, A. L. P., Kaski, J. P., Tavazzi, L., Tendera, M., Maupain, C., Laroche, C., Rubis, P., Jurcut, R., Calo, L., Helio, T. M., Sinagra, G., Zdravkovic, M., Kavoliuniene, A., Felix, S. B., Grzybowski, J., Losi, M. A., Asselbergs, F. W., Garcia-Pinilla, J. M., Salazar-Mendiguchia, J., Mizia-Stec, K., Maggioni, A. P., Anastasakis, A., Biagini, E., Bilinska, Z., Castro, F. J., Celutkiene, J., Chakova, N., Chmielewski, P., Drago, F., Frigy, A., Frustaci, A., Garcia-Pavia, P., Hinic, S., Kindermann, I., Limongelli, G., Medrano, C., Monserrat, L., Olusegun-Joseph, A., Ripoll-Vera, T., Lopes, L. R., Saad, A., Sala, S., Seferovic, P. M., Sepp, R., Urbano-Moral, J. A., Villacorta, E., Wybraniec, M., Yotti, R., Zachara, E., Zorio, E., Charron, Philippe, Elliott, Perry M., Gimeno, Juan R., Caforio, Alida L. P., Kaski, Juan Pablo, Tavazzi, Luigi, Tendera, Michal, Maupain, Carole, Laroche, Cécile, Rubis, Pawel, Jurcut, Ruxandra, Calò, Leonardo, Heliö, Tiina M., Sinagra, Gianfranco, Zdravkovic, Marija, Kavoliuniene, Aušra, Felix, Stephan B., Grzybowski, Jacek, Losi, Maria-Angela, Asselbergs, Folkert W., García-Pinilla, José Manuel, Salazar-Mendiguchia, Joel, Mizia-Stec, Katarzyna, Maggioni, Aldo P., Anastasakis, Ari, Biagini, Elena, Bilinska, Zofia, Castro, Francisco Jose, Celutkiene, Jelena, Chakova, Natalija, Chmielewski, Przemyslaw, Drago, Fabrizio, Frigy, Attila, Frustaci, Andrea, Garcia-Pavia, Pablo, Hinic, Sasa, Kindermann, Ingrid, Limongelli, Giuseppe, Medrano, Constancio, Monserrat, Lorenzo, Olusegun-Joseph, Akinsanya, Ripoll-Vera, Toma, Lopes, Luis Rocha, Saad, Aly, Sala, Simone, Seferovic, Petar M., Sepp, Robert, Urbano-Moral, Jose Angel, Villacorta, Eduardo, Wybraniec, Maciej, Yotti, Raquel, Zachara, Elisabetta, Zorio, Esther, Charron, P, Elliott, Pm, Gimeno, Jr, Caforio, Alp, Kaski, Jp, Tavazzi, L, Tendera, M, Maupain, C, Laroche, C, Rubis, P, Jurcut, R, Calò, L, Heliö, Tm, Sinagra, G, Zdravkovic, M, Kavoliuniene, A, Felix, Sb, Grzybowski, J, Losi, Ma, Asselbergs, Fw, García-Pinilla, Jm, Salazar-Mendiguchia, J, Mizia-Stec, K, and Maggioni, Ap
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Male ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Defibrillator ,0302 clinical medicine ,Dilated ,Age Factor ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,Arrhythmogenic Right Ventricular Dysplasia ,Cardiomyopathy, Restrictive ,adult ,Hypertrophic cardiomyopathy ,Age Factors ,Disease Management ,Dilated cardiomyopathy ,Middle Aged ,Magnetic Resonance Imaging ,3. Good health ,Arrhythmogenic right ventricular dysplasia ,Europe ,Arrhythmogenic right ventricular ,Female ,Cardiology and Cardiovascular Medicine ,Cardiomyopathies ,Human ,Adult ,Cardiomyopathy, Dilated ,Registry ,medicine.medical_specialty ,Cardiomyopathies, adult ,Restrictive ,Context (language use) ,Right ventricular cardiomyopathy ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Cardiomyopathie ,business.industry ,Restrictive cardiomyopathy ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Prospective Studie ,Hypertrophic ,business ,Defibrillators - Abstract
Aims The Cardiomyopathy Registry of the EURObservational Research Programme is a prospective, observational, and multinational registry of consecutive patients with four cardiomyopathy subtypes: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). We report the baseline characteristics and management of adults enrolled in the registry. ................................................................................................................................................................................................... Methods and results A total of 3208 patients were enrolled by 69 centres in 18 countries [HCM (n = 1739); DCM (n = 1260); ARVC (n = 143); and RCM (n = 66)]. Differences between cardiomyopathy subtypes (P < 0.001) were observed for age at diagnosis, history of familial disease, history of sustained ventricular arrhythmia, use of magnetic resonance imaging or genetic testing, and implantation of defibrillators. When compared with probands, relatives had a lower age at diagnosis (P < 0.001), but a similar rate of symptoms and defibrillators. When compared with the Long-Term phase, patients of the Pilot phase (enrolled in more expert centres) had a more frequent rate of familial disease (P < 0.001), were more frequently diagnosed with a rare underlying disease (P < 0.001), and more frequently implanted with a defibrillator (P = 0.023). Comparing four geographical areas, patients from Southern Europe had a familial disease more frequently (P < 0.001), were more frequently diagnosed in the context of a family screening (P < 0.001), and more frequently diagnosed with a rare underlying disease (P < 0.001). ................................................................................................................................................................................................... Conclusion By providing contemporary observational data on characteristics and management of patients with cardiomyopathies, the registry provides a platform for the evaluation of guideline implementation. Potential gaps with existing recommendations are discussed as well as some suggestions for improvement of health care provision in Europe.
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- 2018
37. Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy
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Giovanni Esposito, Laura Papa, Laura Galastri, Massimo Imbriaco, Carla Contaldi, Gianluigi Condorelli, Michael V.G. Latronico, Roberta Roncarati, Gloria Saccani Jotti, Paula A. da Costa Martins, Maria Angela Losi, Sandro Betocchi, Chiara Viviani Anselmi, Elena Cavarretta, Leon J. De Windt, Anna Franzone, Cardiologie, RS: CARIM - R2 - Cardiac function and failure, Roncarati, R, Anselmi, Cv, Losi, Ma, Papa, L, Cavarretta, E, Costa Martins, Pd, Jotti, G, Franzone, A, Galastri, L, Latronico, Mv, Imbriaco, Massimo, Esposito, Giovanni, De Windt, L, Betocchi, Sandro, and Condorelli, G.
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Pathology ,medicine.medical_specialty ,business.industry ,fibrosis ,Hypertrophic cardiomyopathy ,myocardial remodeling ,hypertrophic cardiomyopathy ,Left ventricular hypertrophy ,medicine.disease ,3. Good health ,Muscle hypertrophy ,Circulating MicroRNA ,Downregulation and upregulation ,circulating micrornas ,Fibrosis ,microRNA ,circulating microRNAs ,cardiovascular system ,medicine ,Cancer research ,Biomarker (medicine) ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives The purpose of this paper was to determine whether microRNAs (miRNAs) involved in myocardial remodeling were differentially expressed in the blood of hypertrophic cardiomyopathy (HCM) patients, and whether circulating miRNAs correlated with the degree of left ventricular hypertrophy and fibrosis. Background miRNAs—small, noncoding ribonucleic acids (RNAs) that regulate gene expression by inhibiting RNA translation—modulate cellular function. Myocardial miRNAs modulate processes such as cardiomyocyte (CM) hypertrophy, excitation–contraction coupling, and apoptosis; non–CM-specific miRNAs regulate myocardial vascularization and fibrosis. Recently, the possibility that circulating miRNAs may be biomarkers of cardiovascular disease has been raised. Methods Forty-one HCM patients were characterized with conventional transthoracic echocardiography and cardiac magnetic resonance. Peripheral plasma levels of 21 miRNAs were assessed by quantitative real-time polymerase chain reaction and were compared with levels in a control group of 41 age- and sex-matched blood donors. Results Twelve miRNAs (miR-27a, -199a-5p, -26a, -145, -133a, -143, -199a-3p, -126-3p, -29a, -155, -30a, and -21) were significantly increased in HCM plasma. However, only 3 miRNAs (miR-199a-5p, -27a, and -29a) correlated with hypertrophy; more importantly, only miR-29a correlated also with fibrosis. Conclusions Our data suggest that cardiac remodeling associated with HCM determines a significant release of miRNAs into the bloodstream: the circulating levels of both cardiac- and non–cardiac-specific miRNAs are significantly increased in the plasma of HCM patients. However, correlation with left ventricular hypertrophy parameters holds true for only a few miRNAs (i.e., miR-199a-5p, -27a, and -29a), whereas only miR-29a is significantly associated with both hypertrophy and fibrosis, identifying it as a potential biomarker for myocardial remodeling assessment in HCM.
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- 2014
38. Comparison of hemodynamic adaptation to orthostatic stress in patients with hypertrophic cardiomyopathy with or without syncope and in vasovagal syncope
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Anna Violante, Raffaella Lombardi, Carlo G. Tocchetti, Massimo Chiariello, Fiore Manganelli, Maria Angela Losi, Alberto Cuocolo, Quirino Ciampi, Carlo Briguori, Giovanni Storto, Sandro Betocchi, Manganelli, F, Betocchi, S, Ciampi, Q, Storto, G, Losi, Ma, Violante, A, Briguori, C, Tocchetti, Cg, Lombardi, R, Cuocolo, A, and Chiariello, M
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Adult ,Male ,medicine.medical_specialty ,Cardiac output ,Diastole ,Cardiomyopathy ,Syncope ,Tilt table test ,Tilt-Table Test ,Internal medicine ,Syncope, Vasovagal ,medicine ,Humans ,Cardiac Output ,Radionuclide Imaging ,Vasovagal syncope ,Analysis of Variance ,Chi-Square Distribution ,biology ,medicine.diagnostic_test ,business.industry ,Hemodynamics ,Syncope (genus) ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,medicine.disease ,biology.organism_classification ,Adaptation, Physiological ,medicine.anatomical_structure ,Echocardiography ,Case-Control Studies ,Vascular resistance ,Cardiology ,Female ,Vascular Resistance ,Hypotension ,Cardiology and Cardiovascular Medicine ,business - Abstract
This study was designed to investigate whether, in patients with hypertrophic cardiomyopathy (HC), tilt-induced volume unloading triggers a peripheral reflex similar to that seen in patients with a history of vasovagal syncope or rather acts through an intrinsic cardiac mechanism secondary to diastolic dysfunction. Thirty-seven patients with HC (10 with and 27 without a history of syncope), 10 patients with vasovagal syncope, and 9 controls underwent 70 degrees head-up tilt for 45 minutes during continuous radionuclide monitoring of left ventricular function. We focused on the initial 5 minutes into the tilt test, well before symptoms occurred, to exclude that the observed hemodynamic changes were the consequence rather than the cause of syncope. HC patients with previous syncope and vasovagal patients experienced significant hypotension after the initial 5 minutes of tilt. Only HC patients with a history of syncope had a significant decrease in cardiac output, which began at the initial stage of the test. Systemic vascular resistance decreased in vasovagal patients, but increased in the HC syncopal group. Baseline peak filling rate was lower (2.4 +/- 0.5 vs 3.3 +/- 1.1 stroke counts/s, p = 0.03) and a "pseudonormal" or a restrictive pattern of left ventricular filling was more frequent (70% vs 26%, p = 0.02) in HC patients with than without a history of syncope. Thus, significant hypotension or frank syncope during orthostatic stress in HC patients with a history of syncope is due to an early decrease in cardiac output, which occurs well before the onset of symptoms; such impaired hemodynamic adaptation seems to be related to diastolic dysfunction.
- Published
- 2002
39. The prognostic impact of dynamic ventricular dyssynchrony in patients with idiopathic dilated cardiomyopathy and narrow QRS
- Author
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Donato Mele, Eustachio Agricola, Lucia Riegler, Sergio Mondillo, Antonello D'Andrea, Maurizio Galderisi, Luigi P. Badano, Stefano Nistri, Maria Angela Losi, Piercarlo Ballo, D'Andrea, Antonello, Mele, Donato, Nistri, Stefano, Riegler, Lucia, Galderisi, Maurizio, Agricola, Eustachio, Losi, MARIA ANGELA, Ballo, Piercarlo, Mondillo, Sergio, Badano, Luigi P., D'Andrea, A, Mele, D, Nistri, S, Riegler, L, Galderisi, M, Agricola, E, Losi, Ma, Ballo, P, Mondillo, S, and Badano, Lp.
- Subjects
Male ,Radiology, Nuclear Medicine and Imaging ,medicine.medical_treatment ,Left ,Dilated cardiomyopathy ,Longitudinal Studie ,Predictive Value of Test ,Arrhythmias ,Severity of Illness Index ,Ventricular Dysfunction, Left ,Electrocardiography ,Nuclear Medicine and Imaging ,Dilated ,Ventricular Dysfunction ,Longitudinal Studies ,Prospective Studies ,Multivariate Analysi ,Cardiac resynchronization therapy ,Ejection fraction ,General Medicine ,Middle Aged ,Prognosis ,Survival Rate ,Echocardiography ,cardiovascular system ,Cardiology ,Disease Progression ,Exercise echocardiography ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,Cardiac ,Echocardiography, Stress ,Human ,Cardiomyopathy, Dilated ,medicine.medical_specialty ,Dynamic dyssynchrony ,Functional mitral regurgitation ,Aged ,Arrhythmias, Cardiac ,Humans ,Multivariate Analysis ,Predictive Value of Tests ,Proportional Hazards Models ,ROC Curve ,Risk Assessment ,Cardiomyopathy ,Prognosi ,Diastole ,Stress ,QRS complex ,Internal medicine ,Echocardiography, Stre ,Idiopathic dilated cardiomyopathy ,medicine ,cardiovascular diseases ,Ventricular dyssynchrony ,business.industry ,medicine.disease ,Prospective Studie ,Heart failure ,Proportional Hazards Model ,business - Abstract
Aims Asynchronous myocardial contraction adversely influences left ventricular (LV) function and is therefore associated with a poor prognosis in heart failure. Exercise-induced change in ventricular dyssynchrony may be an important determinant of dynamic changes in cardiac output and mitral regurgitation. Methods and results A prospective, longitudinal study was designed with pre-defined dyssynchrony index and outcome variables to test the hypothesis that dynamic dyssynchrony is associated with worse long-term event-free survival in patients with dilated cardiomyopathy (DCM) and ‘narrow’ QRS complex. One-hundred eighty patients (62 ± 8 years; 110 males) with NYHA class II–III, idiopathic DCM, ejection fraction ≤35%, and QRS duration
- Published
- 2013
40. The relationship between early left ventricular myocardial alterations and reduced coronary flow reserve in non-insulin-dependent diabetic patients with microvascular angina
- Author
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Antonello, D'Andrea, Stefano, Nistri, Francesca, Castaldo, Maurizio, Galderisi, Donato, Mele, Eustachio, Agricola, Maria Angela, Losi, Sergio, Mondillo, Paolo Nicola, Marino, P, Marino, D'Andrea, A, Nistri, S, Castaldo, F, Galderisi, M, Mele, D, Agricola, E, Losi, Ma, Mondillo, S, Marino, Pn., Galderisi, Maurizio, Marino, Pn, D'Andrea, A., Nistri, S., Castaldo, F., Galderisi, M., Mele, D., Agricola, E., Losi, M. A., Mondillo, S., and Marino, P. N.
- Subjects
Male ,medicine.medical_specialty ,Diabetes mellitu ,Coronary flow reserve ,Time Factors ,Population ,Diastole ,Tissue Doppler Imaging ,Microvascular angina ,Coronary circulation ,Ventricular Dysfunction, Left ,Internal medicine ,Diabetes mellitus ,Coronary Circulation ,Medicine ,Humans ,Interventricular septum ,education ,Microvascular Angina ,education.field_of_study ,Ejection fraction ,business.industry ,Middle Aged ,medicine.disease ,Two-dimensional strain imaging ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,Cardiology ,Speckle Tracking Echocardiography ,Female ,Tissue Doppler ,Cardiology and Cardiovascular Medicine ,business ,Diabetic Angiopathies - Abstract
Aims: To evaluate left ventricular (LV) systolic and diastolic myocardial function, and their relation to coronary flow reserve in patients with non-insulin-dependent diabetes mellitus (DM) and microvascular angina. Methods and results: We selected a population of 45 normotensive patients with DM (56.3 ± 8.2 years; 25 males) with LV ejection fraction > 50% and microvascular angina (anginal pain, positive imaging stress test and normal coronary angiography). Thirty-five age- and sex-matched healthy controls were also enrolled. All the patients underwent standard echocardiography, Tissue Doppler (TDI), two-dimensional strain (2DSE) imaging, and coronary flow reserve (CFR) measurement. LV myocardial early diastolic peak velocities (Em) and peak systolic 2DSE were reduced in both interventricular septum (IVS) and LV lateral wall (p < 0.01) in DM, as well as CFR (1.89 ± 0.7 vs 2.55 ± 0.56, p < 0.0001) compared with controls. By multivariate analysis, the independent determinants of Em were glycated haemoglobin (β coefficient = - 0.36; p < 0.01) and age (β = - 0.46, p < 0.001), while global longitudinal strain was predicted by glycated haemoglobin (β = 0.48, P < 0.001) and by the duration of the disease (β = 0.38, P < 0.005). An independent association between LV global longitudinal strain and CFR (β coefficient = - 0.47, p < 0.001) in DM patients was also evidenced. Conclusions: TDI, 2DSE and CFR are valuable non-invasive and easy-repeatable tools for detecting LV myocardial and coronary function in DM patients with microvascular angina. © 2011 Published by Elsevier Ireland Ltd.
- Published
- 2012
41. Methodological approach for the assessment of ultrasound reproducibility of cardiac structure and function: a proposal of the study group of Echocardiography of the Italian Society of Cardiology (Ultra Cardia SIC) part I
- Author
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Luigi P. Badano, Sergio Mondillo, Sgalambro A, Giuliano Marti, Pasquale Perrone Filardi, Paolo Marino, Piercarlo Ballo, Pasquale Innelli, Roberto Marchioli, Antonello D'Andrea, Maurizio Galderisi, Donato Mele, Giuseppe Mercuro, Stefano Nistri, Eustachio Agricola, Maria Angela Losi, Alessandro Santoro, Roberta Esposito, Denisa Muraru, Galderisi, Maurizio, Nistri, S, Mondillo, S, Losi, Ma, Innelli, P, Mele, D, Muraru, D, D'Andrea, A, Ballo, P, Sgalambro, A, Esposito, R, Marti, G, Santoro, Alessandro, Agricola, E, Badano, Lp, Marchioli, R, Filardi, Pp, Mercuro, G, Marino, Pn, Galderisi, M, Santoro, A, Marino, Pn., Losi, M, Badano, L, Filardi, P, and Marino, P
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Quality Assurance, Health Care ,media_common.quotation_subject ,Cardiology ,advanced technologies ,Documentation ,Data acquisition ,Clinical trials ,peripheral laboratories ,Internal medicine ,medicine ,Echo core laboratory ,Humans ,Radiology, Nuclear Medicine and imaging ,Quality (business) ,media_common ,Reproducibility ,Modality (human–computer interaction) ,Modalities ,business.industry ,standardizing image ,Reproducibility of Results ,Quality control ,Heart ,General Medicine ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,core laboratory ,Echocardiography, Doppler ,Doppler echocardiography ,Clinical trial ,Italy ,Radiology Nuclear Medicine and imaging ,Echocardiography ,lcsh:RC666-701 ,Technical Notes ,business ,Cardiology and Cardiovascular Medicine ,Quality assurance - Abstract
When applying echo-Doppler imaging for either clinical or research purposes it is very important to select the most adequate modality/technology and choose the most reliable and reproducible measurements. Quality control is a mainstay to reduce variability among institutions and operators and must be obtained by using appropriate procedures for data acquisition, storage and interpretation of echo-Doppler data. This goal can be achieved by employing an echo core laboratory (ECL), with the responsibility for standardizing image acquisition processes (performed at the peripheral echo-labs) and analysis (by monitoring and optimizing the internal intra- and inter-reader variability of measurements). Accordingly, the Working Group of Echocardiography of the Italian Society of Cardiology decided to design standardized procedures for imaging acquisition in peripheral laboratories and reading procedures and to propose a methodological approach to assess the reproducibility of echo-Doppler parameters of cardiac structure and function by using both standard and advanced technologies. A number of cardiologists experienced in cardiac ultrasound was involved to set up an ECL available for future studies involving complex imaging or including echo-Doppler measures as primary or secondary efficacy or safety end-points. The present manuscript describes the methodology of the procedures (imaging acquisition and measurement reading) and provides the documentation of the work done so far to test the reproducibility of the different echo-Doppler modalities (standard and advanced). These procedures can be suggested for utilization also in non referall echocardiographic laboratories as an "inside" quality check, with the aim at optimizing clinical consistency of echo-Doppler data.
- Published
- 2011
42. Echocardiography in patients with hypertrophic cardiomyopathy: usefullness of old and new techniques in the diagnosis and pathophysiological assessment
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Simona Buralli, Sergio Mondillo, Susanna Sciomer, Maurizio Galderisi, Franco Cecchi, Maria Angela Losi, Eustachio Agricola, Antonello D'Andrea, Stefano Nistri, Iacopo Olivotto, Piercarlo Ballo, Arcangelo D'Errico, Sandro Betocchi, Donato Mele, Losi, Ma, Nistri, S, Galderisi, M, Betocchi, S, Cecchi, F, Olivotto, I, Agricola, E, Ballo, P, Buralli, S, D'Andrea, A, D'Errico, A, Mele, D, Sciomer, S, Mondillo, S., Losi, MARIA ANGELA, Galderisi, Maurizio, and Betocchi, Sandro
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Diastole ,Ischemia ,Cardiomyopathy ,Disease ,Review ,macromolecular substances ,echocardiographic ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,cardiovascular diseases ,Angiology ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Echocardiography ,food and beverages ,General Medicine ,medicine.disease ,inherited cardiomyopathy ,Pathophysiology ,diastolic dysfunction ,lcsh:RC666-701 ,Radiology Nuclear Medicine and imaging ,Cardiology ,cardiovascular system ,business ,Cardiology and Cardiovascular Medicine - Abstract
Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiomyopathy. The identification of patients with HCM is sometimes still a challenge. Moreover, the pathophysiology of the disease is complex because of left ventricular hyper-contractile state, diastolic dysfunction, ischemia and obstruction which can be coexistent in the same patient. In this review, we discuss the current and emerging echocardiographic methodology that can help physicians in the correct diagnostic and pathophysiological assessment of patients with HCM.
- Published
- 2010
43. Transcatheter closure of patent ductus arteriosus reverses left ventricular dysfunction in a septuagenarian
- Author
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Antonio Rapacciuolo, Massimo Cavallaro, Federico Piscione, Massimo Chiariello, Francesco Borgia, Roberta De Rosa, Maria Carmen De Angelis, Maria Angela Losi, Francesca Esposito, Rapacciuolo, Antonio, Losi, MARIA ANGELA, Borgia, Francesco, De Angelis, M. C., Esposito, F., Cavallaro, M., De Rosa, R., Piscione, Federico, Chiariello, Massimo, Losi, Ma, De Angelis, Mc, Esposito, F, Cavallaro, M, De Rosa, R, and Chiariello, M.
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Male ,Cardiac Catheterization ,medicine.medical_specialty ,Percutaneous ,Hypertension, Pulmonary ,Hemodynamics ,Coronary Angiography ,septuagenarian ,Electrocardiography ,Ventricular Dysfunction, Left ,Recurrence ,Ductus arteriosus ,Internal medicine ,medicine ,Humans ,Medical history ,Transcatheter closure ,Treatment Failure ,Cardiac Surgical Procedures ,Ductus Arteriosus, Patent ,Ligation ,Coronary atherosclerosis ,Aged ,Heart Failure ,medicine.diagnostic_test ,business.industry ,Equipment Design ,General Medicine ,medicine.disease ,Pulmonary hypertension ,Echocardiography, Doppler, Color ,Dyspnea ,medicine.anatomical_structure ,Heart failure ,patent ductus arteriosu ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 70-year-old man was admitted because of a 6-month history of progressive dyspnoea on exertion. The medical history showed that he suffered from patent ductus arteriosus (PDA) that was closed at 35 years of age by surgical ligation. Subsequently, up to year 1992, no evidence of residual left-to-right shunt was found. When he first came to our attention, we performed an echocardiographic test evidencing left ventricular dilation and contractile dysfunction and a recurrence of PDA. To exclude other possible causes of congestive heart failure, we performed several tests, including a coronary angiogram that showed coronary atherosclerosis without significant lesions. The haemodynamic study confirmed that the PDA was associated with a mild pulmonary hypertension with a QP: QS of 2: 1. The patient did not report any cardiovascular risk factor. Therefore, we concluded that PDA was responsible for congestive heart failure in this patient. We performed percutaneous closure of PDA, which was able to reverse left ventricular dilation and dysfunction, improving the patient's symptoms, at 1 month as well as 4 months after the interventional procedure. Although this kind of device is frequently used in the paediatric population, adult patients may present different challenges in proper management, such as poor visualization, calcification and pulmonary hypertension. In the description of the case reported here, we show that a PDA can present as congestive heart failure in the elderly. Percutaneous closure can be very effective in ameliorating left ventricular performance as well as symptoms.
- Published
- 2009
44. Massive chronic atrial thrombosis
- Author
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Massimo Chiariello, Massimo Ragni, Mariano Aversa, Paolo Golino, Maria Angela Losi, Sandro Betocchi, Losi, MARIA ANGELA, Golino, P., Betocchi, Sandro, Ragni, M., Aversa, M., Chiariello, Massimo, Losi, Ma, Golino, Paolo, Betocchi, S, Ragni, M, Aversa, M, and Chiariello, M.
- Subjects
Male ,medicine.medical_specialty ,Old thrombus ,Atrial thrombosis ,Left atrial ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Heart Atria ,Thrombus ,Aspirin ,business.industry ,Coronary Thrombosis ,Warfarin ,Anticoagulants ,Middle Aged ,medicine.disease ,Thrombosis ,Embolism ,Chronic Disease ,cardiovascular system ,Cardiology ,Drug Therapy, Combination ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Transesophageal ,medicine.drug - Abstract
We report herein a patient in whom a very large and old thrombus in the left atrium was detected by transesophageal echocardiography. The patient started warfarin and aspirin. After 2 years of therapy, transesophageal echocardiography showed the complete resolution of thrombus in the absence of clinical evidence of embolism. This case indicates that large and presumably organized thrombi may be dissolved by an anticoagulant therapy, although the lytic activity of warfarin has never been demonstrated. Transesophageal echocardiography helps in the identification and follow-up of such conditions and contributes to understanding of warfarin action in left atrial thrombosis. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2003
45. Myocardial collagen turnover in hypertrophic cardiomyopathy
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Marianna Miranda, Raffaella Lombardi, Gianluigi D'Alessandro, Maria Angela Losi, Mariano Aversa, Quirino Ciampi, Carlo G. Tocchetti, Sandro Betocchi, Alessandra Cacace, Massimo Chiariello, Lombardi, R, Betocchi, S, Losi, Ma, Tocchetti, CARLO GABRIELE, Aversa, M, Miranda, M, D'Alessandro, G, Cacace, A, Ciampi, Q, Chiariello, M., Lombardi, R., Betocchi, Sandro, Losi, MARIA ANGELA, Aversa, M., Miranda, M., D'Alessandro, G., Cacace, A., Ciampi, Q., and Chiariello, Massimo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart disease ,Cardiomyopathy ,Diastole ,Matrix metalloproteinase ,Severity of Illness Index ,Collagen Type I ,Ventricular Function, Left ,Extracellular matrix ,Reference Values ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Tissue Inhibitor of Metalloproteinase-1 ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Radioimmunoassay ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Peptide Fragments ,Endocrinology ,Matrix Metalloproteinase 9 ,Echocardiography ,Interstitial collagenase ,Matrix Metalloproteinase 2 ,Female ,Collagen ,Matrix Metalloproteinase 1 ,Cardiology and Cardiovascular Medicine ,business ,Peptides ,Biomarkers ,Procollagen - Abstract
Background— Myocardial interstitial fibrosis is a characteristic of hypertrophic cardiomyopathy (HCM). This study evaluates the collagen turnover in HCM and its impact on left ventricular (LV) diastolic function. Methods and Results— Thirty-six HCM patients and 14 sex- and age-matched controls were studied. Collagen turnover was assessed as follows. By radioimmunoassay, a byproduct of collagen III synthesis (PIIINP) and 3 peptides resulting from collagen I synthesis (PICP and PINP) and degradation (ICTP) were measured. By ELISA, matrix metalloproteinases (MMPs) were determined, as follows: active MMP-2; active MMP-9; and MMP-1 as active, free (as active MMP-1 plus its precursor), and total (as free MMP-1 plus MMP-1/tissue inhibitor complexes). Tissue inhibitor of metalloproteinases-1 (TIMP-1) was also assayed. All patients underwent echocardiography. The difference in duration between transmitral forward (A) and pulmonary venous retrograde (AR) waves (A−Ar) was considered an estimate of passive diastolic function. Furthermore, restrictive or pseudonormal LV filling patterns were considered to identify patients with passive diastolic dysfunction. Patients had higher levels of PIIINP, ICTP, MMP-2, MMP-9, and total TIMP-1 than did controls. PIIINP was inversely related to LV end-diastolic diameter. A−Ar was inversely related to PICP, PINP, and their differences with ICTP (estimates of collagen I buildup). Furthermore, A−Ar was directly related to MMP-1 and MMP-2. Conclusions— As compared with controls, collagen turnover is enhanced in HCM patients. As collagen I synthesis prevails over degradation and MMP-1 and MMP-2 are inhibited, passive diastolic dysfunction occurs in patients with HCM.
- Published
- 2003
46. Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy
- Author
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Alberto Cuocolo, Quirino Ciampi, Massimo Chiariello, Giovanni Storto, Elpidio Pezzella, Fiore Manganelli, Maria Angela Losi, Raffaella Lombardi, Filippo Finizio, Sandro Betocchi, Ciampi, Q, Betocchi, Sandro, Lombardi, R, Manganelli, F, Storto, G, Losi, Ma, Pezzella, E, Finizio, F, Cuocolo, Alberto, and Chiariello, M.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cardiac output ,Hemodynamics ,Blood Pressure ,Sudden death ,Ventricular Function, Left ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Cardiac Output ,Radionuclide Angiography ,Analysis of Variance ,Ejection fraction ,business.industry ,Hypertrophic cardiomyopathy ,Stroke Volume ,Stroke volume ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Blood pressure ,Echocardiography ,Case-Control Studies ,Vascular resistance ,Cardiology ,Exercise Test ,cardiovascular system ,Female ,business ,Cardiology and Cardiovascular Medicine - Abstract
OBJECTIVES: We sought to assess the hemodynamics of exercise in patients with hypertrophic cardiomyopathy (HCM), with and without an exercise- induced abnormal blood pressure (BP) response, by ambulatory radionuclide monitoring of left ventricular (LV) function with the VEST device (Capintec Inc., Ramsey, New Jersey). BACKGROUND: Blood pressure fails to increase >20 mm Hg during exercise in about one-third of patients with HCM. This carries a high risk of sudden death. METHODS: Forty-three patients with HCM and 14 control subjects underwent maximal symptom- limited exercise on a treadmill during VEST. The VEST data were averaged for 1 min and analyzed at baseline, 3 min and peak exercise. The LV end- diastolic, end-systolic and stroke volumes, cardiac output and systemic vascular resistance were expressed as the percentage of baseline. RESULTS: Ejection fraction and stroke volume fell in patients with HCM, although they increased in control subjects (p < 0.001 and p = 0.002, respectively). Cardiac output increased significantly more in control subjects than in patients with HCM (p = 0.001). In 17 patients with HCM (39%) with an abnormal BP response, ejection fraction and stroke volume fell more (p = 0.032 and p = 0.009, respectively) and cardiac output increased less (p = 0.001) than they did in patients with HCM with a normal BP response. Systemic vascular resistance decreased similarly in patients with HCM, irrespective of the BP response. CONCLUSIONS: In patients with HCM with and without an abnormal BP response, abnormal hemodynamic adaptation to exercise was qualitatively similar but quantitatively different. An abnormal BP response was associated with exercise-induced LV systolic dysfunction. This causes hemodynamic instability, associated with a high risk of sudden cardiac death.
- Published
- 2002
47. Mid-term results of the valve-on-valve technique for bioprosthetic failure
- Author
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Maria Angela Losi, Paolo Stassano, Nicola Spampinato, Antonino Musumeci, Cesare Gagliardi, Stassano, Paolo, Musumeci, A., Losi, Ma, Gagliardi, C., Spampinato, N., Musumeci, Antonino, Losi, MARIA ANGELA, Gagliardi, Cesare, and Spampinato, Nicola
- Subjects
Pulmonary and Respiratory Medicine ,Aortic valve ,Adult ,Male ,Reoperation ,medicine.medical_specialty ,Treatment outcome ,Mid term results ,Mechanical valve ,Mitral valve ,Medicine ,Humans ,Aged ,Prosthetic valve ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,business.industry ,Follow up studies ,General Medicine ,Middle Aged ,Surgery ,Prosthesis Failure ,medicine.anatomical_structure ,Treatment Outcome ,Aortic Valve ,Heart Valve Prosthesis ,Aortic valve surgery ,Mitral Valve ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: Redo operations for bioprosthesis malfunction can sometimes be technically very demanding and cardiac structures may be damaged. Excising only the leaflets of the damaged bioprosthesis and leaving the old ring in situ on which the ‘new’ mechanical valve is sutured can, in very selected cases, represent a solution. Methods: Twenty-two patients were operated on, with the valve-on-valve technique, from September 1991 through December 1992. There were three operative deaths. Results: The surviving 19 patients were followed-up from 83 to 98 months (mean 90.5 months.). There were two late deaths. The patients were examined clinically and with transthoracic and transesophageal echocardiograms. All patients were in good condition and the echocardiographic examinations showed no clinically important gradients across the prostheses. Conclusions: The valve-on-valve technique, in certain difficult situations, can give successful mid-term results. q 2000 Elsevier Science B.V. All rights reserved.
- Published
- 2000
48. Determinants of aortic artifacts during transesophageal echocardiography of the ascending aorta
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Massimo Chiariello, Fiore Manganelli, Maria Angela Losi, Gabriele Iannelli, Leonardo Pace, Carlo Briguori, Nicola Spampinato, Quirino Ciampi, Sandro Betocchi, Losi, MARIA ANGELA, Betocchi, Sandro, C., Briguori, F., Manganelli, Q., Ciampi, L., Pace, Iannelli, Gabriele, N., Spampinato, M., Chiariello, Losi, Ma, Betocchi, S, Briguori, C, Manganelli, F, Ciampi, Q, Pace, Leonardo, Spampinato, N, and Chiariello, M.
- Subjects
medicine.medical_specialty ,Aorta, Thoracic ,Dissection (medical) ,Diagnosis, Differential ,Left atrial ,Predictive Value of Tests ,Positive predicative value ,medicine.artery ,Ascending aorta ,Medicine ,Humans ,Retrospective Studies ,Aortic dissection ,Observer Variation ,Artifact (error) ,Aorta ,Aortic Aneurysm, Thoracic ,business.industry ,Vascular disease ,Reproducibility of Results ,medicine.disease ,Aortic Dissection ,cardiovascular system ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Artifacts ,Echocardiography, Transesophageal - Abstract
Background The origin of artifacts of the ascending aorta during transesophageal echocardiography has not been widely studied. This study was undertaken to investigate in vivo whether anatomic features could determine the appearance of artifacts. Methods and Results Transesophageal echocardiograms of 46 patients studied for suspected dissection with proven diagnosis (30 patients with and 16 without ascending aortic dissection) were reviewed. The incidence of artifacts was 46%, and it was similar in patients with and those without dissection (chi-square 0.516; P = not significant). Artifacts were located in the aortic lumen twice as far from the transducer as the atrial-aortic interface. The aortic diameter was larger in patients with than in those without artifacts (6.4 ± 1.1 vs 4.2 ± 0.9 cm, P 5 cm and an atrial-aortic ratio ≤0.6 predicted the artifact appearance with good sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy; these parameters reached a value of 100% by analysis only of patients without dissection. Conclusions An ascending aortic diameter >5.0 cm that exceeds the left atrial diameter with an atrial-aortic ratio ≤0.6 creates in vivo the conditions for the reverberation of the atrial-aortic interface within the aorta. Therefore, in patients with such anatomic features, artifacts must be suspected in the presence of linear structures within the aorta. (Am Heart J 1999;137:967-73.)
- Published
- 1999
49. Influence of left ventricular cavity size on clinical presentation in hypertrophic cardiomyopathy
- Author
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Marco Salvatore, Quirino Ciampi, Massimo Chiariello, Filippo Finizio, Pasquale Perrone-Filardi, Fiore Manganelli, Leonardo Pace, Carlo Briguori, Sandro Betocchi, Elpidio Pezzella, Maria Angela Losi, Manganelli, F, Betocchi, S, Losi, Ma, Briguori, C, Pace, L, Ciampi, Q, PERRONE FILARDI, P, Salvatore, M, Finizio, F, Pezzella, E, Chiariello, Massimo, Pace, Leonardo, Perronefilardi, P, Chiariello, M., Manganelli, F., Betocchi, Sandro, Losi, MARIA ANGELA, Briguori, C., PERRONE FILARDI, Pasquale, Finizio, P, Perrone Filardi, P, and Salvatore, Marco
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart disease ,Adolescent ,Heart Ventricles ,Diastole ,Cardiomyopathy ,Hemodynamics ,Ventricular Function, Left ,Ventricular Outflow Obstruction ,Radionuclide angiography ,Internal medicine ,Medicine ,Humans ,Sinus rhythm ,Radionuclide Angiography ,Aged ,Ultrasonography ,Body surface area ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The aim of this study was to assess whether left ventricular (LV) cavity size relates to functional impairment and syncope in patients with hypertrophic cardiomyopathy (HC). LV diastolic dysfunction influences functional limitation in HC. A reduced LV end-diastolic dimension may underlie impaired diastolic properties and be implicated in hemodynamic syncope. Eighty-two consecutive patients with HC (off drugs, in sinus rhythm) underwent echocardiography to measure LV end-diastolic dimension in the short-axis view (indexed to the body surface area) and radionuclide angiography (n = 50) to calculate peak filling rate (normalized to stroke counts/s). Patients in New York Heart Association functional classes II to IV had smaller LV end-diastolic dimension (23.2 +/- 2.6 vs 25.5 +/- 2.5 mm/M2, p = 0.0001) and lower peak filling rate (4.3 +/- 1.4 vs 5.1 +/- 1.3 stroke counts/s, p = 0.036) than those in New York Heart Association class I. LV end-diastolic diameter was correlated to peak filling rate (r = 0.37; p = 0.008). The most potent predictors of functional limitation were LV end-diastolic dimension (relative risk [RR] 0.63, confidence interval [CI] 0.45 to 0.88; p = 0.008), age (RR 1.09, CI 1.03 to 1.17; p = 0.003), and LV thickness score (RR 1.08, CI 1.02 to 1.13; p = 0.003). LV cavity size was smaller in patients with functional limitation irrespective of obstruction and hypertrophy. Patients with differed from those without a history of syncope for a smaller LV end-diastolic dimension (23.2 +/- 2.5 vs 25.0 +/- 2.7 mm/M2, p = 0.008), which was the only independent predictor of syncope (RR 0.77, CI 0.63 to 0.95; p = 0.013). Thus, a small LV cavity size is associated with functional limitation and history of syncope in HC.
- Published
- 1999
50. Exercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function
- Author
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Maria Angela Losi, Carlo Briguori, Mario Condorelli, Fiore Manganelli, Rossella Gottilla, Massimo Romano, Quirino Ciampi, Sandro Betocchi, Massimo Chiariello, Raffaella Lombardi, Briguori, C, Betocchi, S, Romano, M, Manganelli, F, Losi, Af, Ciampi, Q, Gottilla, R, Lombardi, R, Condorelli, Mario, Chiariello, M., Briguori, C., Betocchi, Sandro, Romano, M., Manganelli, F., Losi, Ma, and Condorelli, M
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Heart disease ,Diastole ,Doppler echocardiography ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,Oxygen Consumption ,Left atrial ,Internal medicine ,medicine ,Humans ,Diastolic function ,Heart Atria ,Exercise ,Aged ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,VO2 max ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Exercise capacity ,medicine.disease ,Echocardiography, Doppler ,Pulmonary Veins ,Exercise Test ,Linear Models ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity - Abstract
Some studies have demonstrated that left ventricular (LV) diastolic function is the principal determinant of impaired exercise capacity in hypertrophic cardiomyopathy (HC). In this study we sought the capability of echocardiographic indexes of diastolic function in predicting exercise capacity in patients with HC. We studied 52 patients with HC while they were not on drugs;12 of them had LV tract obstruction at rest. Diastolic function was assessed by M-mode and Doppler echocardiography by measuring: (1) left atrial fractional shortening, and the slope of posterior aortic wall displacement during early atrial emptying on M-mode left atrial tracing; and (2) Doppler-derived transmitral and pulmonary venous flow velocity indexes. Exercise capacity was assessed by maximum oxygen consumption by cardiopulmonary test during cycloergometer upright exercise. Maximum oxygen consumption correlated with the left atrial fractional shortening (r = 0.63, p0.001), the slope of posterior aortic wall displacement during early atrial emptying (r = 0.55, p0.001), age (r = -0.50; p0.001), pulmonary venous diastolic anterograde velocity (r = 0.41, p0.01), and the systolic filling fraction (r = -0.43; p0.01). By stepwise multiple linear regression analysis, left atrial fractional shortening and the pulmonary venous systolic filling fraction were the only determinants of the maximum oxygen consumption (multiple r = 0.70; p0.001). Exercise capacity did not correlate with Doppler-derived transmitral indexes. Thus, in patients with HC, exercise capacity was determined by passive LV diastolic function, as assessed by the left atrial M-mode and Doppler-derived pulmonary venous flow velocities.
- Published
- 1999
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