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2. Differences between familial and sporadic dilated cardiomyopathy: ESC EORP Cardiomyopathy & Myocarditis registry

Author

Asselbergs F. W., Sammani A., Elliott P., Gimeno J. R., Tavazzi L., Tendera M., Kaski J. P., Maggioni A. P., Rubis P. P., Jurcut R., Helio T., Calo L., Sinagra G., Zdravkovic M., Olivotto I., Kavoliuniene A., Laroche C., Caforio A. L. P., Charron P., Komissarova S., Chakova N., Niyazova S., Linhart A., Kuchynka P., Palecek T., Podzimkova J., Fikrle M., Nemecek E., Bundgaard H., Tfelt-Hansen J., Theilade J., Thune J. J., Axelsson A., Mogensen J., Henriksen F., Hey T., Nielsen S. K., Videbaek L., Andreasen S., Arnsted H., Saad A., Ali M., Lommi J., Nieminennew M. S., Dubourg O., Mansencal N., Arslan M., Siam Tsieu V., Damy T., Guellich A., Guendouz S., Tissot C. M., Lamine A., Rappeneau S., Hagege A., Desnos M., Bachet A., Hamzaoui M., Isnard R., Legrand L., Maupain C., Gandjbakhch E., Kerneis M., Pruny J. -F., Bauer A., Pfeiffer B., Felix S. B., Dorr M., Kaczmarek S., Lehnert K., Pedersen A. -L., Beug D., Bruder M., Bohm M., Kindermann I., Linicus Y., Werner C., Neurath B., Schild-Ungerbuehler M., Seggewiss H., Neugebauer A., McKeown P., Muir A., McOsker J., Jardine T., Divine G., Lorenzini M., Watkinson O., Wicks E., Iqbal H., Mohiddin S., O'Mahony C., Sekri N., Carr-White G., Bueser T., Rajani R., Clack L., Damm J., Jones S., Sanchez-Vidal R., Smith M., Walters T., Wilson K., Rosmini S., Anastasakis A., Ritsatos K., Vlagkouli V., Forster T., Sepp R., Borbas J., Nagy V., Tringer A., Kakonyi K., Szabo L. A., Maleki M., Noohi Bezanjani F., Amin A., Naderi N., Parsaee M., Taghavi S., Ghadrdoost B., Jafari S., Khoshavi M., Rapezzi C., Biagini E., Corsini A., Gagliardi C., Graziosi M., Longhi S., Milandri A., Ragni L., Palmieri S., Arretini A., Castelli G., Cecchi F., Fornaro A., Tomberli B., Spirito P., Devoto E., Della Bella P., Maccabelli G., Sala S., Guarracini F., Peretto G., Russo M. G., Calabro R., Pacileo G., Limongelli G., Masarone D., Pazzanese V., Rea A., Rubino M., Tramonte S., Valente F., Caiazza M., Cirillo A., Del Giorno G., Esposito A., Gravino R., Marrazzo T., Trimarco B., Losi M. -A., Di Nardo C., Giamundo A., Musella F., Pacelli F., Scatteia A., Canciello G., Caforio A., Iliceto S., Calore C., Leoni L., Perazzolo Marra M., Rigato I., Tarantini G., Schiavo A., Testolina M., Arbustini E., Di Toro A., Giuliani L. P., Serio A., Fedele F., Frustaci A., Alfarano M., Chimenti C., Drago F., Baban A., Lanzillo C., Martino A., Uguccioni M., Zachara E., Halasz G., Re F., Carriere C., Merlo M., Ramani F., Krivickiene A., Tamuleviciute-Prasciene E., Viezelis M., Celutkiene J., Balkeviciene L., Laukyte M., Paleviciute E., Pinto Y., Wilde A., Van Der Heijden J., Van Laake L., De Jonge N., Hassink R., Kirkels J. H., Ajuluchukwu J., Olusegun-Joseph A., Ekure E., Mizia-Stec K., Czekaj A., Sikora-Puz A., Skoczynska A., Wybraniec M., Rubis P., Dziewiecka E., Wisniowska-Smialek S., Bilinska Z., Chmielewski P., Foss-Nieradko B., Michalak E., Stepien-Wojno M., Mazek B., Rocha Lopes L., Almeida A. R., Cruz I., Gomes A. C., Pereira A. R., Brito D., Madeira H., Francisco A. R., Menezes M., Moldovan O., Oliveira Guimaraes T., Silva D., Ginghina C., Mursa A., Popescu B. A., Apetrei E., Militaru S., Mircea Coman I., Frigy A., Fogarasi Z., Kocsis I., Szabo I. A., Fehervari L., Nikitin I., Resnik E., Komissarova M., Lazarev V., Shebzukhova M., Ustyuzhanin D., Blagova O., Alieva I., Kulikova V., Lutokhina Y., Pavlenko E., Varionchik N., Ristic A. D., Seferovic P. M., Veljic I., Zivkovic I., Milinkovic I., Pavlovic A., Radovanovic G., Simeunovic D., Aleksic M., Djokic J., Hinic S., Klasnja S., Mircetic K., Monserrat L., Fernandez X., Garcia-Giustiniani D., Larranaga J. M., Ortiz-Genga M., Barriales-Villa R., Martinez-Veira C., Veira E., Cequier A., Salazar-Mendiguchia J., Manito N., Gonzalez J., Fernandez-Aviles F., Medrano C., Yotti R., Cuenca S., Espinosa M. A., Mendez I., Zatarain E., Alvarez R., Garcia-Pavia P., Briceno A., Cobo-Marcos M., Dominguez F., De Teresa Galvan E., Garcia Pinilla J. M., Abdeselam-Mohamed N., Lopez-Garrido M. A., Morcillo Hidalgo L., Ortega-Jimenez M. V., Robles Mezcua A., Guijarro-Contreras A., Gomez-Garcia D., Robles-Mezcua M., Gimeno Blanes J. R., Castro F. J., Munoz Esparza C., Sabater Molina M., Sorli Garcia M., Lopez Cuenca D., Ripoll-Vera T., Alvarez J., Nunez J., Gomez Y., Sanchez Fernandez P. L., Villacorta E., Avila C., Bravo L., Diaz-Pelaez E., Gallego-Delgado M., Garcia-Cuenllas L., Plata B., Lopez-Haldon J. E., Pena Pena M. L., Cantero Perez E. M., Zorio E., Arnau M. A., Sanz J., Marques-Sulex E., University Medical Center [Utrecht], University College of London [London] (UCL), Hospital Univeristario Virgen de la Arrixaca, University Hospital of Ferrara and Maria Cecilia Hospital, Medical University of Silesia, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Chair of Medical Biochemistry, Jagiellonian University - Medical College, Chair of Medical Biochemistry, Emergency Hospital Floreasca Bucharest, Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, Sector 1, 014461 Bucharest, Romania, University of Helsinki, Policlinico Casilino (Ospedale Policlinico Casilino), University of Trieste, University of Belgrade [Belgrade], Careggi University Hospital, Lithuanian University of health Sciences [Kaunas], Universita degli Studi di Padova, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia], Medical University of Silesia (SUM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Università degli studi di Trieste = University of Trieste, Università degli Studi di Padova = University of Padua (Unipd), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), HAL-SU, Gestionnaire, Asselbergs, F. W., Sammani, A., Elliott, P., Gimeno, J. R., Tavazzi, L., Tendera, M., Kaski, J. P., Maggioni, A. P., Rubis, P. P., Jurcut, R., Helio, T., Calo, L., Sinagra, G., Zdravkovic, M., Olivotto, I., Kavoliuniene, A., Laroche, C., Caforio, A. L. P., Charron, P., Komissarova, S., Chakova, N., Niyazova, S., Linhart, A., Kuchynka, P., Palecek, T., Podzimkova, J., Fikrle, M., Nemecek, E., Bundgaard, H., Tfelt-Hansen, J., Theilade, J., Thune, J. J., Axelsson, A., Mogensen, J., Henriksen, F., Hey, T., Nielsen, S. K., Videbaek, L., Andreasen, S., Arnsted, H., Saad, A., Ali, M., Lommi, J., Nieminennew, M. S., Dubourg, O., Mansencal, N., Arslan, M., Siam Tsieu, V., Damy, T., Guellich, A., Guendouz, S., Tissot, C. M., Lamine, A., Rappeneau, S., Hagege, A., Desnos, M., Bachet, A., Hamzaoui, M., Isnard, R., Legrand, L., Maupain, C., Gandjbakhch, E., Kerneis, M., Pruny, J. -F., Bauer, A., Pfeiffer, B., Felix, S. B., Dorr, M., Kaczmarek, S., Lehnert, K., Pedersen, A. -L., Beug, D., Bruder, M., Bohm, M., Kindermann, I., Linicus, Y., Werner, C., Neurath, B., Schild-Ungerbuehler, M., Seggewiss, H., Neugebauer, A., Mckeown, P., Muir, A., Mcosker, J., Jardine, T., Divine, G., Lorenzini, M., Watkinson, O., Wicks, E., Iqbal, H., Mohiddin, S., O'Mahony, C., Sekri, N., Carr-White, G., Bueser, T., Rajani, R., Clack, L., Damm, J., Jones, S., Sanchez-Vidal, R., Smith, M., Walters, T., Wilson, K., Rosmini, S., Anastasakis, A., Ritsatos, K., Vlagkouli, V., Forster, T., Sepp, R., Borbas, J., Nagy, V., Tringer, A., Kakonyi, K., Szabo, L. A., Maleki, M., Noohi Bezanjani, F., Amin, A., Naderi, N., Parsaee, M., Taghavi, S., Ghadrdoost, B., Jafari, S., Khoshavi, M., Rapezzi, C., Biagini, E., Corsini, A., Gagliardi, C., Graziosi, M., Longhi, S., Milandri, A., Ragni, L., Palmieri, S., Arretini, A., Castelli, G., Cecchi, F., Fornaro, A., Tomberli, B., Spirito, P., Devoto, E., Della Bella, P., Maccabelli, G., Sala, S., Guarracini, F., Peretto, G., Russo, M. G., Calabro, R., Pacileo, G., Limongelli, G., Masarone, D., Pazzanese, V., Rea, A., Rubino, M., Tramonte, S., Valente, F., Caiazza, M., Cirillo, A., Del Giorno, G., Esposito, A., Gravino, R., Marrazzo, T., Trimarco, B., Losi, M. -A., Di Nardo, C., Giamundo, A., Musella, F., Pacelli, F., Scatteia, A., Canciello, G., Caforio, A., Iliceto, S., Calore, C., Leoni, L., Perazzolo Marra, M., Rigato, I., Tarantini, G., Schiavo, A., Testolina, M., Arbustini, E., Di Toro, A., Giuliani, L. P., Serio, A., Fedele, F., Frustaci, A., Alfarano, M., Chimenti, C., Drago, F., Baban, A., Lanzillo, C., Martino, A., Uguccioni, M., Zachara, E., Halasz, G., Re, F., Carriere, C., Merlo, M., Ramani, F., Krivickiene, A., Tamuleviciute-Prasciene, E., Viezelis, M., Celutkiene, J., Balkeviciene, L., Laukyte, M., Paleviciute, E., Pinto, Y., Wilde, A., Van Der Heijden, J., Van Laake, L., De Jonge, N., Hassink, R., Kirkels, J. H., Ajuluchukwu, J., Olusegun-Joseph, A., Ekure, E., Mizia-Stec, K., Czekaj, A., Sikora-Puz, A., Skoczynska, A., Wybraniec, M., Rubis, P., Dziewiecka, E., Wisniowska-Smialek, S., Bilinska, Z., Chmielewski, P., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Mazek, B., Rocha Lopes, L., Almeida, A. R., Cruz, I., Gomes, A. C., Pereira, A. R., Brito, D., Madeira, H., Francisco, A. R., Menezes, M., Moldovan, O., Oliveira Guimaraes, T., Silva, D., Ginghina, C., Mursa, A., Popescu, B. A., Apetrei, E., Militaru, S., Mircea Coman, I., Frigy, A., Fogarasi, Z., Kocsis, I., Szabo, I. A., Fehervari, L., Nikitin, I., Resnik, E., Komissarova, M., Lazarev, V., Shebzukhova, M., Ustyuzhanin, D., Blagova, O., Alieva, I., Kulikova, V., Lutokhina, Y., Pavlenko, E., Varionchik, N., Ristic, A. D., Seferovic, P. M., Veljic, I., Zivkovic, I., Milinkovic, I., Pavlovic, A., Radovanovic, G., Simeunovic, D., Aleksic, M., Djokic, J., Hinic, S., Klasnja, S., Mircetic, K., Monserrat, L., Fernandez, X., Garcia-Giustiniani, D., Larranaga, J. M., Ortiz-Genga, M., Barriales-Villa, R., Martinez-Veira, C., Veira, E., Cequier, A., Salazar-Mendiguchia, J., Manito, N., Gonzalez, J., Fernandez-Aviles, F., Medrano, C., Yotti, R., Cuenca, S., Espinosa, M. A., Mendez, I., Zatarain, E., Alvarez, R., Garcia-Pavia, P., Briceno, A., Cobo-Marcos, M., Dominguez, F., De Teresa Galvan, E., Garcia Pinilla, J. M., Abdeselam-Mohamed, N., Lopez-Garrido, M. A., Morcillo Hidalgo, L., Ortega-Jimenez, M. V., Robles Mezcua, A., Guijarro-Contreras, A., Gomez-Garcia, D., Robles-Mezcua, M., Gimeno Blanes, J. R., Castro, F. J., Munoz Esparza, C., Sabater Molina, M., Sorli Garcia, M., Lopez Cuenca, D., Ripoll-Vera, T., Alvarez, J., Nunez, J., Gomez, Y., Sanchez Fernandez, P. L., Villacorta, E., Avila, C., Bravo, L., Diaz-Pelaez, E., Gallego-Delgado, M., Garcia-Cuenllas, L., Plata, B., Lopez-Haldon, J. E., Pena Pena, M. L., Cantero Perez, E. M., Zorio, E., Arnau, M. A., Sanz, J., Marques-Sulex, E., Cardiology, ACS - Heart failure & arrhythmias, HUS Heart and Lung Center, Clinicum, Department of Medicine, Kardiologian yksikkö, Helsinki University Hospital Area, and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)

Subjects
Registrie, lcsh:Diseases of the circulatory (Cardiovascular) system, EUROBSERVATIONAL RESEARCH-PROGRAM, Dilated cardiomyopathy, Europe, Familial, Genetic, Prognosis, Sporadic, Adult, Humans, Prospective Studies, Registries, Cardiomyopathies, Cardiomyopathy, Dilated, Myocarditis, Cardiomyopathy, 030204 cardiovascular system & hematology, 0302 clinical medicine, Original Research Articles, Dilated, PILOT, Original Research Article, 030212 general & internal medicine, Prospective cohort study, Ejection fraction, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Guideline adherence, 3. Good health, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Prognosi, FREQUENCY, 03 medical and health sciences, Internal medicine, medicine, Cardiomyopathie, Genetic testing, business.industry, medicine.disease, Prospective Studie, lcsh:RC666-701, 3121 General medicine, internal medicine and other clinical medicine, Heart failure, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; AimsDilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non‐familial (sporadic) DCM (SDCM) across Europe.Methods and resultsPatients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy & Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P < 0.01), had less severe disease phenotype at presentation (P < 0.02), more favourable baseline cardiovascular risk profiles (P ≤ 0.007), and less medication use (P ≤ 0.042). Outcome at 1 year was similar and predicted by NYHA class (HR 0.45; 95% CI [0.25–0.81]) and LVEF per % decrease (HR 1.05; 95% CI [1.02–1.08]. Throughout Europe, patients with FDCM received more genetic testing (47% vs. 8%, P < 0.01) and had higher genetic yield (55% vs. 22%, P < 0.01).ConclusionsWe observed that FDCM and SDCM have significant differences at baseline but similar short‐term prognosis. Whether modification of associated cardiovascular risk factors provide opportunities for treatment remains to be investigated. Our results also show a prevalent role of genetics in FDCM and a non‐marginal yield in SDCM although genetic testing is largely neglected in SDCM. Limited genetic testing and heterogeneity in panels provides a scaffold for improvement of guideline adherence.

Published
2021
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3. HCM-AF South Italy score for prediction of new-onset atrial fibrillation in patients with hypertrophic cardiomyopathy: data from a derivation and validation italian cohorts

Author

Todde, G, primary, Monda, E, additional, Canciello, G, additional, Lioncino, M, additional, Lombardi, R, additional, Rubino, M, additional, Borrelli, F, additional, Caiazza, M, additional, Paoletta, D, additional, De Simone, G, additional, Pacileo, G, additional, Esposito, G, additional, Limongelli, G, additional, and Losi, M A, additional

Published
2022
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6. Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry

Author

Lopes, Luis R, Losi, Maria-Angela, Sheikh, Nabeel, Laroche, Cécile, Charron, Philippe, Gimeno, Juan, Kaski, Juan P, Maggioni, Aldo P, Tavazzi, Luigi, Arbustini, Eloisa, Brito, Dulce, Celutkiene, Jelena, Hagege, Albert, Linhart, Ales, Mogensen, Jens, Garcia-Pinilla, José Manuel, Ripoll-Vera, Tomas, Seggewiss, Hubert, Villacorta, Eduardo, Caforio, Alida, Elliott, Perry M, Komissarova, S, Chakova, N, Niyazova, S, Linhart, A, Kuchynka, P, Palecek, T, Podzimkova, J, Fikrle, M, Nemecek, E, Bundgaard, H, Tfelt-Hansen, J, Theilade, J, Thune, J J, Axelsson, A, Mogensen, J, Henriksen, F, Hey, T, Nielsen, S K, Videbaek, L, Andreasen, S, Arnsted, H, Saad, A, Ali, M, Lommi, J, Helio, T, Nieminen, M S, Dubourg, O, Mansencal, N, Arslan, M, Tsieu, V Siam, Damy, T, Guellich, A, Guendouz, S, Tissot, C M, Lamine, A, Rappeneau, S, Hagege, A, Desnos, M, Bachet, A, Hamzaoui, M, Charron, P, Isnard, R, Legrand, L, Maupain, C, Gandjbakhch, E, Kerneis, M, Pruny, J-F, Bauer, A, Pfeiffer, B, Felix, S B, Dorr, M, Kaczmarek, S, Lehnert, K, Pedersen, A-L, Beug, D, Bruder, M, Böhm, M, Kindermann, I, Linicus, Y, Werner, C, Neurath, B, Schild-Ungerbuehler, M, Seggewiss, H, Neugebauer, A, Mckeown, P, Muir, A, Mcosker, J, Jardine, T, Divine, G, Elliott, P, Lorenzini, M, Watkinson, O, Wicks, E, Iqbal, H, Mohiddin, S, O'Mahony, C, Sekri, N, Carr-White, G, Bueser, T, Rajani, R, Clack, L, Damm, J, Jones, S, Sanchez-Vidal, R, Smith, M, Walters, T, Wilson, K, Rosmini, S, Anastasakis, A, Ritsatos, K, Vlagkouli, V, Forster, T, Sepp, R, Borbas, J, Nagy, V, Tringer, A, Kakonyi, K, Szabo, L A, Maleki, M, Bezanjani, F Noohi, Amin, A, Naderi, N, Parsaee, M, Taghavi, S, Ghadrdoost, B, Jafari, S, Khoshavi, M, Rapezzi, C, Biagini, E, Corsini, A, Gagliardi, C, Graziosi, M, Longhi, S, Milandri, A, Ragni, L, Palmieri, S, Olivotto, I, Arretini, A, Castelli, G, Cecchi, F, Fornaro, A, Tomberli, B, Spirito, P, Devoto, E, Bella, P Della, Maccabelli, G, Sala, S, Guarracini, F, Peretto, G, Russo, M G, Calabro, R, Pacileo, G, Limongelli, G, Masarone, D, Pazzanese, V, Rea, A, Rubino, M, Tramonte, S, Valente, F, Caiazza, M, Cirillo, A, Del Giorno, G, Esposito, A, Gravino, R, Marrazzo, T, Trimarco, B, Losi, M-A, Nardo, C Di, Giamundo, A, Musella, F, Pacelli, F, Scatteia, A, Canciello, G, Caforio, A, Iliceto, S, Calore, C, Leoni, L, Marra, M Perazzolo, Rigato, I, Tarantini, G, Schiavo, A, Testolina, M, Arbustini, E, Toro, A Di, Giuliani, L P, Serio, A, Fedele, F, Frustaci, A, Alfarano, M, Chimenti, C, Drago, F, Baban, A, Calò, L, Lanzillo, C, Martino, A, Uguccioni, M, Zachara, E, Halasz, G, Re, F, Sinagra, G, Carriere, C, Merlo, M, Ramani, F, Kavoliuniene, A, Krivickiene, A, Tamuleviciute-Prasciene, E, Viezelis, M, Celutkiene, J, Balkeviciene, L, Laukyte, M, Paleviciute, E, Pinto, Y, Wilde, A, Asselbergs, F W, Sammani, A, Van Der Heijden, J, Van Laake, L, De Jonge, N, Hassink, R, Kirkels, J H, Ajuluchukwu, J, Olusegun-Joseph, A, Ekure, E, Mizia-Stec, K, Tendera, M, Czekaj, A, Sikora-Puz, A, Skoczynska, A, Wybraniec, M, Rubis, P, Dziewiecka, E, Wisniowska-Smialek, S, Bilinska, Z, Chmielewski, P, Nieradko, B Foss, Michalak, E, Stepien-Wojno, M, Mazek, B, Lopes, L Rocha, Almeida, A R, Cruz, I, Gomes, A C, Pereira, A R, Brito, D, Madeira, H, Francisco, A R, Menezes, M, Moldovan, O, Guimaraes, T Oliveira, Silva, D, Ginghina, C, Jurcut, R, Mursa, A, Popescu, B A, Apetrei, E, Militaru, S, Coman, I Mircea, Frigy, A, Fogarasi, Z, Kocsis, I, Szabo, I A, Fehervari, L, Nikitin, I, Resnik, E, Komissarova, M, Lazarev, V, Shebzukhova, M, Ustyuzhanin, D, Blagova, O, Alieva, I, Kulikova, V, Lutokhina, Y, Pavlenko, E, Varionchik, N, Ristic, A D, Seferovic, P M, Veljic, I, Zivkovic, I, Milinkovic, I, Pavlovic, A, Radovanovic, G, Simeunovic, D, Zdravkovic, M, Aleksic, M, Djokic, J, Hinic, S, Klasnja, S, Mircetic, K, Monserrat, L, Fernandez, X, Garcia-Giustiniani, D, Larrañaga, J M, Ortiz-Genga, M, Barriales-Villa, R, Martinez-Veira, C, Veira, E, Cequier, A, Salazar-Mendiguchia, J, Manito, N, Gonzalez, J, Fernández-Avilés, F, Medrano, C, Yotti, R, Cuenca, S, Espinosa, M A, Mendez, I, Zatarain, E, Alvarez, R, Pavia, P Garcia, Briceno, A, Cobo-Marcos, M, Dominguez, F, Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N, Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A, Gomez-Garcia, D, Robles-Mezcua, M, Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, Ripoll-Vera, T, Alvarez, J, Nunez, J, Gomez, Y, Fernandez, P L Sanchez, Villacorta, E, Avila, C, Bravo, L, Diaz-Pelaez, E, Gallego-Delgado, M, Garcia-Cuenllas, L, Plata, B, Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E, Arnau, M A, Sanz, J, Marques-Sule, E, Gale, Christopher Peter, Beleslin, Branko, Budaj, Andrzej, Chioncel, Ovidiu, Dagres, Nikolaos, Danchin, Nicolas, Erlinge, David, Emberson, Jonathan, Glikson, Michael, Gray, Alastair, Kayikcioglu, Meral, Maggioni, Aldo, Nagy, Klaudia Vivien, Nedoshivin, Aleksandr, Petronio, Anna-Sonia, Hesselink, Jolien Roo, Wallentin, Lars, Zeymer, Uwe, Caforio, Alida, Blanes, Juan Ramon Gimeno, Charron, Philippe, Elliott, Perry, Kaski, Juan Pablo, Maggioni, Aldo P, Tavazzi, Luigi, Tendera, Michal, Komissarova, S., Chakova, N., Niyazova, S., Linhart, A., Kuchynka, P., Palecek, T., Podzimkova, J., Fikrle, M., Nemecek, E., Bundgaard, H., Tfelt-Hansen, J., Theilade, J., Thune, J J, Axelsson, A., Mogensen, J., Henriksen, F., Hey, T., Nielsen, S K, Videbaek, L., Andreasen, S., Arnsted, H., Saad, A., Ali, M., Lommi, J., Helio, T., Nieminen, M S, Dubourg, O., Mansencal, N., Arslan, M., Tsieu, V Siam, Damy, T., Guellich, A., Guendouz, S., Tissot, C M, Lamine, A., Rappeneau, S., Hagege, A., Desnos, M., Bachet, A., Hamzaoui, M., Charron, P., Isnard, R., Legrand, L., Maupain, C., Gandjbakhch, E., Kerneis, M., Pruny, J-F, Bauer, A., Pfeiffer, B., Felix, S B, Dorr, M., Kaczmarek, S., Lehnert, K., Pedersen, A-L, Beug, D., Bruder, M., Böhm, M., Kindermann, I., Linicus, Y., Werner, C., Neurath, B., Schild-Ungerbuehler, M., Seggewiss, H., Neugebauer, A., McKeown, P., Muir, A., McOsker, J., Jardine, T., Divine, G., Elliott, P., Lorenzini, M., Watkinson, O., Wicks, E., Iqbal, H., Mohiddin, S., O'Mahony, C., Sekri, N., Carr-White, G., Bueser, T., Rajani, R., Clack, L., Damm, J., Jones, S., Sanchez-Vidal, R., Smith, M., Walters, T., Wilson, K., Rosmini, S., Anastasakis, A., Ritsatos, K., Vlagkouli, V., Forster, T., Sepp, R., Borbas, J., Nagy, V., Tringer, A., Kakonyi, K., Szabo, L A, Maleki, M., Bezanjani, F Noohi, Amin, A., Naderi, N., Parsaee, M., Taghavi, S., Ghadrdoost, B., Jafari, S., Khoshavi, M., Rapezzi, C., Biagini, E., Corsini, A., Gagliardi, C., Graziosi, M., Longhi, S., Milandri, A., Ragni, L., Palmieri, S., Olivotto, I., Arretini, A., Castelli, G., Cecchi, F., Fornaro, A., Tomberli, B., Spirito, P., Devoto, E., Bella, P Della, Maccabelli, G., Sala, S., Guarracini, F., Peretto, G., Russo, M G, Calabro, R., Pacileo, G., Limongelli, G., Masarone, D., Pazzanese, V., Rea, A., Rubino, M., Tramonte, S., Valente, F., Caiazza, M., Cirillo, A., Del Giorno, G., Esposito, A., Gravino, R., Marrazzo, T., Trimarco, B., Losi, M-A, Di Nardo, C., Giamundo, A., Musella, F., Pacelli, F., Scatteia, A., Canciello, G., Caforio, A., Iliceto, S., Calore, C., Leoni, L., Marra, M Perazzolo, Rigato, I., Tarantini, G., Schiavo, A., Testolina, M., Arbustini, E., Di Toro, A., Giuliani, L P, Serio, A., Fedele, F., Frustaci, A., Alfarano, M., Chimenti, C., Drago, F., Baban, A., Calò, L., Lanzillo, C., Martino, A., Uguccioni, M., Zachara, E., Halasz, G., Re, F., Sinagra, G., Carriere, C., Merlo, M., Ramani, F., Kavoliūnienė, Aušra, Krivickienė, Aušra, Tamulevičiūtė-Prascienė, Eglė, Vieželis, Mindaugas, Balkevičienė, Laura, Laukytė, M., Palevičiūtė, Eglė, Pinto, Y., Wilde, A., Asselbergs, F W, Sammani, A., Van Der Heijden, J., Van Laake, L., De Jonge, N., Hassink, R., Kirkels, J H, Ajuluchukwu, J., Olusegun-Joseph, A., Ekure, E., Mizia-Stec, K., Tendera, M., Czekaj, A., Sikora-Puz, A., Skoczynska, A., Wybraniec, M., Rubis, P., Dziewiecka, E., Wisniowska-Smialek, S., Bilinska, Z., Chmielewski, P., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Mazek, B., Lopes, L Rocha, Almeida, A R, Cruz, I., Gomes, A C, Pereira, A R, Brito, D., Madeira, H., Francisco, A R, Menezes, M., Moldovan, O., Guimaraes, T Oliveira, Silva, D., Ginghina, C., Jurcut, R., Mursa, A., Popescu, B A, Apetrei, E., Militaru, S., Coman, I Mircea, Frigy, A., Fogarasi, Z., Kocsis, I., Szabo, I A, Fehervari, L., Nikitin, I., Resnik, E., Komissarova, M., Lazarev, V., Shebzukhova, M., Ustyuzhanin, D., Blagova, O., Alieva, I., Kulikova, V., Lutokhina, Y., Pavlenko, E., Varionchik, N., Ristic, A D, Seferovic, P M, Veljic, I., Zivkovic, I., Milinkovic, I., Pavlovic, A., Radovanovic, G., Simeunovic, D., Zdravkovic, M., Aleksic, M., Djokic, J., Hinic, S., Klasnja, S., Mircetic, K., Monserrat, L., Fernandez, X., Garcia-Giustiniani, D., Larrañaga, J M, Ortiz-Genga, M., Barriales-Villa, R., Martinez-Veira, C., Veira, E., Cequier, A., Salazar-Mendiguchia, J., Manito, N., Gonzalez, J., Fernández-Avilés, F., Medrano, C., Yotti, R., Cuenca, S., Espinosa, M A, Mendez, I., Zatarain, E., Alvarez, R., Pavia, P Garcia, Briceno, A., Cobo-Marcos, M., Dominguez, F., Galvan, E De Teresa, Pinilla, J M García, Abdeselam-Mohamed, N., Lopez-Garrido, M A, Hidalgo, L Morcillo, Ortega-Jimenez, M V, Mezcua, A Robles, Guijarro-Contreras, A., Gomez-Garcia, D., Robles-Mezcua, M., Blanes, J R Gimeno, Castro, F J, Esparza, C Munoz, Molina, M Sabater, García, M Sorli, Cuenca, D Lopez, de Mallorca, Palma, Ripoll-Vera, T., Alvarez, J., Nunez, J., Gomez, Y., Fernandez, P L Sanchez, Villacorta, E., Avila, C., Bravo, L., Diaz-Pelaez, E., Gallego-Delgado, M., Garcia-Cuenllas, L., Plata, B., Lopez-Haldon, J E, Pena Pena, M L, Perez, E M Cantero, Zorio, E., Arnau, M A, Sanz, J., Marques-Sule, E., Repositório da Universidade de Lisboa, Lopes, Lr, Losi, Ma, Sheikh, N, Laroche, C, Charron, P, Gimeno, J, Kaski, Jp, Maggioni, Ap, Tavazzi, L, Arbustini, E, Brito, D, Celutkiene, J, Hagege, A, Linhart, A, Mogensen, J, Garcia-Pinilla, Jm, Ripoll-Vera, T, Seggewiss, H, Villacorta, E, Caforio, A, and Elliott, Pm

Subjects
Genotype, Health Policy, Diabetes, Cardiovascular risk factors, Hypertension, Hypertrophic cardiomyopathy, Obesity, Cardiomyopathy, Hypertrophic, Ventricular Dysfunction, Left, diabete, Cardiovascular Diseases, Risk Factors, Heart Disease Risk Factors, cardiovascular risk factor, Humans, Female, 03.02. Klinikai orvostan, Cardiology and Cardiovascular Medicine, Cardiomyopathies, obesity
Abstract

© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited., Aims: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. Methods and results: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI) and clinical traits was analyzed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene.The prevalence of HT, DM and obesity (Ob) was 37%, 10%, and 21%, respectively. HT, DM and Ob were associated with older age (p

Published
2022

9. Dimmi che Cuore hai e ti Dirò chi sei

Author

Losi M. A. and Losi, M. A.

Abstract

Il cuore può raccontare chi siamo. I geni che ereditiamo e le nostre abitudini ne influenzano la struttura ed il funzionamento. Un cuore pesante secondo gli antichi Egizi indicava che il defunto in vita aveva peccato. Nel III millennio non possiamo che confermare questa credenza : se il cuore pesa più del normale perchè si ispessisce e/o perchè di dilata, qualcosa non ha funzionato o non funziona nel nostro corpo. Il libro condurrà il lettore in un viaggio attraverso gli strumenti, sia del singolo individuo sia della ricerca scientifics, per avere sempre un cuore leggero.

Published
2020

22. Viral Load and Risk of Tuberculosis in HIV Infection

Author

Lange, Christoph, Van Leth, Frank, Sester, Martina, Bruchfeld, J, Julander, I, Bumbacea, D, Cirillo, Dm, Dilektasli, Ag, Eyuboglu, Fo, Domínguez, J, Latorre, I, Duarte, R, Ernst, M, Gerogianni, I, Girardi, E, Goletti, D, Janssens, Jp, Soccal, Pm, Lange, B, Straub, M, Wagner, D, Losi, M, Markova, R, Matteelli, Alberto, Milburn, H, Ravn, P, Scholman, T, Wolf, T, Yalcin, A., Janssens, Jean-Paul, Gasche-Soccal, Paola Marina Alessandra, Global Health, and Infectious diseases

Subjects
Risk, Tuberculosis, Mycobacterium tuberculosis/isolation & purification, Human immunodeficiency virus (HIV), MEDLINE, HIV Infections, HIV Infections/complications/drug therapy/virology, medicine.disease_cause, Viral/blood, Anti-Retroviral Agents/therapeutic use, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Pharmacology (medical), Viral, 030212 general & internal medicine, ddc:616, Anti-Retroviral Agents, Follow-Up Studies, Incidence, RNA, Viral, Viral Load, Infectious Diseases, Medicine (all), biology, business.industry, Incidence (epidemiology), Follow up studies, biology.organism_classification, medicine.disease, Virology, Tuberculosis/complications, 030228 respiratory system, RNA, business, Viral load
Published
2016
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27. P400CHA2DS2-VASc score and dilated left atrial volume index predict incident atrial fibrillation in hypertensive patients

Author

Imparato, L I, primary, Viggiano, A, additional, Pergola, V, additional, Carella, C, additional, Abbate, F G, additional, Canciello, G, additional, Mongiello, F, additional, Koci, E, additional, Mancusi, C, additional, De Simone, G, additional, Losi, M A, additional, Izzo, R, additional, De Luca, N, additional, Trimarco, B, additional, and Rapacciuolo, A, additional

Published
2018
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31. HFE gene variants and iron induced O2 radical generation in idiopathic pulmonary fibrosis

Author

Sangiuolo F. (1), Puxeddu E. (1), Pezzuto G. (2), Cavalli F. (3), Longo G. (1), Comandini A. (2), Di Pierro D. (4), Pallante M. (1), Sergiacomi G. (5), Simonetti G. (5), Zompatori M. (6), Orlandi A. (7), Magrini A. (1), Amicosante M. (1), Mariani F. (8), Losi M. (2), Fraboni D. (9), Bisetti A. (10), and Saltini C. (1, 2, 3)

Subjects
IPF, nutritional and metabolic diseases, iron homeostasis, HFE, respiratory system, respiratory tract diseases
Abstract

In idiopathic pulmonary fibrosis (IPF), lung accumulation of excessive extracellular iron and macrophage haemosiderin may suggest disordered iron homeostasis leading to recurring microscopic injury and fibrosing damage. The current study population comprised 89 consistent IPF patients and 107 controls. 54 patients and 11 controls underwent bronchoalveolar lavage (BAL). Haemosiderin was assessed by Perls' stain, BAL fluid malondialdehyde (MDA) by high-performance liquid chromatography, BAL cell iron-dependent oxygen radical generation by fluorimetry and the frequency of hereditary haemochromatosis HFE gene variants by reverse dot blot hybridisation. Macrophage haemosiderin, BAL fluid MDA and BAL cell unstimulated iron-dependent oxygen radical generation were all significantly increased above controls (p

Published
2015
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32. Pre-existing and new-onset atrial fibrillation: a meta-analysis of mortality outcomes and cerebrovascular events in 13,795 patients undergoing transcatheter aortic valve implantation

Author

Sannino, A., Gargiulo, G., Gabriele Schiattarella, Perrino, C., Stabile, E., Losi, M. A., Galderisi, M. A., Simone, G. G., Trmarco, B., Esposito, G., Sannino, Anna, Gargiulo, Giuseppe, Schiattarella, GABRIELE GIACOMO, Perrino, Cinzia, Stabile, Eugenio, Losi, MARIA ANGELA, Galderisi, Maurizio, De Simone, G, Trimarco, Bruno, and Esposito, Giovanni

Published
2015

33. Mancanza di correlazione tra segni radiologici di tubercolosi inattiva e risposta immune specifica nei confronti di M. Tuberculosis in pazienti con malattie ematolinfoproliferative

Author

Fantini, R, Losi, M, Ferrari, A, Luppi, F, Spagnolo, P, D'Amico, R, Torricelli, P, Fiocchi, F, Roversi, P, Cerri, S, Rumpianesi, F, Meacci, M, Meccugni, B, Fabbri LM., T, Luppi, M, Richeldi, L, Fantini R, Losi M, Ferrari A, Luppi F, Spagnolo P, D'Amico R, Torricelli P, Fiocchi F, Roversi P, Cerri S, Rumpianesi F, Meacci M, Meccugni B, Fabbri LM. Torelli G, Luppi M, Richeldi L., Fantini, R, Losi, M, Ferrari, A, Luppi, F, Spagnolo, P, D'Amico, R, Torricelli, P, Fiocchi, F, Roversi, P, Cerri, S, Rumpianesi, F, Meacci, M, Meccugni, B, Fabbri LM., T, Luppi, M, Richeldi, L, Fantini R, Losi M, Ferrari A, Luppi F, Spagnolo P, D'Amico R, Torricelli P, Fiocchi F, Roversi P, Cerri S, Rumpianesi F, Meacci M, Meccugni B, Fabbri LM. Torelli G, Luppi M, and Richeldi L.

Published
2010

34. Use of Quantiferon-TB in tube test in the diagnosis of non tuberculous mycobacteria lung disease.

Author

Losi, M, Fabio, A, Dal Monte, P, Peracchi, M, Del Giovane, P, Meacci, M, Luppi, F, Cerri, S, Lombardi, G, Fallico, L, Apice, M, Spagnolo, P, Rumpianesi, F, Manganelli, R, Fabbri, L, Richeldi, L, Losi M, Fabio A, Dal Monte P, Peracchi M, Del Giovane P, Meacci M, Luppi F, Cerri S, Lombardi G, Fallico L, Apice MG, Spagnolo P, Rumpianesi F, Manganelli R, Fabbri LM, Richeldi L., Losi, M, Fabio, A, Dal Monte, P, Peracchi, M, Del Giovane, P, Meacci, M, Luppi, F, Cerri, S, Lombardi, G, Fallico, L, Apice, M, Spagnolo, P, Rumpianesi, F, Manganelli, R, Fabbri, L, Richeldi, L, Losi M, Fabio A, Dal Monte P, Peracchi M, Del Giovane P, Meacci M, Luppi F, Cerri S, Lombardi G, Fallico L, Apice MG, Spagnolo P, Rumpianesi F, Manganelli R, Fabbri LM, and Richeldi L.

Published
2010

35. Tuberculosis infection in young children: a screening based on skin and blood testing

Author

LOMBARDI, GIULIA, DAL MONTE, PAOLA, PACE, ANTONELLA, LANDINI, MARIA PAOLA, Petrucci R, Losi M, Corsini I, Richeldi L, Bernardi F, Lombardi G, Petrucci R, Dal Monte P, Losi M, Corsini I, Pace A, Richeldi L, Bernardi F, and Landini MP

Subjects
IGRA test, QuantiferonTB, TST, CHILDREN, tuberculosi, bacterial infections and mycoses
Abstract

Objectives: progression from latent tuberculosis infection (LTBI) to tuberculosis (TB) is higher in children younger than 5 years because of anergy of their immune system. Accurate diagnosis of LTBI is a desiderable goal in achieving effective TB control particularly in young children, because the preventive chemotherapy is effective and relatively safe. Aim of this study was to evaluate the "performance" of a commercially available Interferon-gamma (IFN-gamma) assay [QuantiFERON-TB Gold In-Tube (QFT-IT); Cellestis Ltd., Victoria, Australia] in this vulnerable population. Methods: in a retrospective study, QFT-IT test was performed in 145 young children ≤ 5 years of age, recent close contact of active pulmonary TB during the period April 2007-December 2010. Tuberculin skin test (TST; 5UI Biocine Test PPD; Chiron, Siena) was available only in 112 (77.2%) children. Results: in our pediatric population: mean age was 2.5 ± 1.5 years, 74 (51%) subjects were born in Italy from immigrant families, 9 (6.2%) were BCG-vaccinated. QFT-IT was positive in 24 (16.6%) children, negative in 112 (77.2%) and indeterminate in 9 (6.2%). TST was positive (cut-off  10 mm) in 28 (25%) of 112 evaluated patients. By statistical analysis, TST and QFT-IT showed a fair agreement: 82.9%, k=0.52. Among the discordant results (n=19): 12 (63.2%) children were TST-positive/QFT-IT-negative, of them 7 (58.3%) were BCG-vaccinated. Three (42.9%) of 7 patients TST-negative/QFT-IT-positive had TB and 4 (57.1%) had LTBI. Among 16 children TST-positive/QFT-IT-positive, 10 had clinical diagnosis of active TB and 6 of LTBI. In this group the analysis of IFN-gamma level as continuous variable revealed: 7/10 (70%) children with active pulmonary TB showed high level of IFN-gamma (10 UI/ml) and a TST size ranging from 10 mm to 15 mm; 3/6 (50%) children with a diagnosed LTBI had high IFN-gamma level 10 UI/ml and a TST size of 11-20 mm. Conclusion: these preliminary data suggest and support the potential advantages of using blood test, e.g. QFT-IT, in young children ≤ 5 years for diagnosing LTBI.

Published
2012

36. Exhaled and non-exhaled non-invasive markers for assessment of respiratory inflammation in patients with stable COPD and healthy smokers

Author

SANTINI, GIUSEPPE, MORES, NADIA, Shohreh, R, Valente, S, Dabrowska, M, Trové, A, ZINI, GINA, CATTANI, PAOLA, FUSO, LEONELLO, Mautone, A, Mondino, C, PAGLIARI, GABRIELLA, Sala, A, Folco, G, AIELLO, MARIA, Pisi, R, Chetta, A, LOSI,m, Clini, E, Ciabattoni, G, MONTUSCHI, PAOLO, SANTINI, GIUSEPPE, MORES, NADIA, Shohreh, R, Valente, S, Dabrowska, M, Trové, A, ZINI, GINA, CATTANI, PAOLA, FUSO, LEONELLO, Mautone, A, Mondino, C, PAGLIARI, GABRIELLA, Sala, A, Folco, G, AIELLO, MARIA, Pisi, R, Chetta, A, LOSI,m, Clini, E, Ciabattoni, G, and MONTUSCHI, PAOLO

Published
2016

37. Prior tuberculin skin test does not induce a false positive result of T-cell interferon-gamma release assays

Author

Losi, M, Ferrara, G, Luppi, F, Piro, R, Cerri, S, Tallarico, S, Andreani, A, D’Amico, R, Roversi, P, Meacci, M, Meccugni, B, Marchetti Dori, I, Caracciolo, R, Fabbri, L, Richeldi, L, Losi M, Ferrara G, Luppi F, Piro R, Cerri S, Tallarico S, Andreani A, D’Amico R, Roversi P, Meacci M, Meccugni B, Marchetti Dori I, Caracciolo R, Fabbri LM, Richeldi L, Losi, M, Ferrara, G, Luppi, F, Piro, R, Cerri, S, Tallarico, S, Andreani, A, D’Amico, R, Roversi, P, Meacci, M, Meccugni, B, Marchetti Dori, I, Caracciolo, R, Fabbri, L, Richeldi, L, Losi M, Ferrara G, Luppi F, Piro R, Cerri S, Tallarico S, Andreani A, D’Amico R, Roversi P, Meacci M, Meccugni B, Marchetti Dori I, Caracciolo R, Fabbri LM, and Richeldi L

Published
2008

38. T-cell Interferon-gamma-release assays performance to detect latent tuberculosis infection in immunocompromised patients

Author

Losi, M, Luppi, F, Roversi, P, Ferrara, G, Cerri, S, Ferrari, A, D’Amico, R, Codeluppi, M, Meacci, M, Luppi, M, Torelli, G, Fabbri, L, Richeldi, L, Losi M, Luppi F, Roversi P, Ferrara G, Cerri S, Ferrari A, D’Amico R, Codeluppi M, Meacci M, Luppi M, Torelli G, Fabbri LM, Richeldi L., Losi, M, Luppi, F, Roversi, P, Ferrara, G, Cerri, S, Ferrari, A, D’Amico, R, Codeluppi, M, Meacci, M, Luppi, M, Torelli, G, Fabbri, L, Richeldi, L, Losi M, Luppi F, Roversi P, Ferrara G, Cerri S, Ferrari A, D’Amico R, Codeluppi M, Meacci M, Luppi M, Torelli G, Fabbri LM, and Richeldi L.

Published
2008

39. Impact of QuantiFERON GOLD In-Tube test in contact tracing among immigrants from high prevalence countries

Author

Losi, M, Cagarelli, R, Ferrara, G, Roversi, S, Luppi, F, D’Amico, R, Cerri, S, Roversi, P, Spagnolo, P, Rumpianesi, F, Meacci, M, Meccugni, B, Fabbri, L, Richeldi, L, Losi M, Cagarelli R, Ferrara G, Roversi S, Luppi F, D’Amico R, Cerri S, Roversi P, Spagnolo P, Rumpianesi F, Meacci M, Meccugni B, Fabbri L, Richeldi L., Losi, M, Cagarelli, R, Ferrara, G, Roversi, S, Luppi, F, D’Amico, R, Cerri, S, Roversi, P, Spagnolo, P, Rumpianesi, F, Meacci, M, Meccugni, B, Fabbri, L, Richeldi, L, Losi M, Cagarelli R, Ferrara G, Roversi S, Luppi F, D’Amico R, Cerri S, Roversi P, Spagnolo P, Rumpianesi F, Meacci M, Meccugni B, Fabbri L, and Richeldi L.

Published
2008

40. Radiological findings of inactive tuberculosis do not correlate with M. tuberculosis-specific T-cell immunity in high risk patients

Author

Luppi, F, Torricelli, P, Roversi, P, Fiocchi, F, Ferrari, A, Luppi, M, D’Amico, R, Losi, M, Meacci, M, Meccugni, B, Rumpianesi, F, Fabbri, L, Richeldi, L, Luppi F, Torricelli P, Roversi P, Fiocchi F, Ferrari A, Luppi M, D’Amico R, Losi M, Meacci M, Meccugni B, Rumpianesi F, Fabbri L, Richeldi L, Luppi, F, Torricelli, P, Roversi, P, Fiocchi, F, Ferrari, A, Luppi, M, D’Amico, R, Losi, M, Meacci, M, Meccugni, B, Rumpianesi, F, Fabbri, L, Richeldi, L, Luppi F, Torricelli P, Roversi P, Fiocchi F, Ferrari A, Luppi M, D’Amico R, Losi M, Meacci M, Meccugni B, Rumpianesi F, Fabbri L, and Richeldi L

Published
2008

41. Impact of QuantiFERON-TB and T-SPOT.TB tests in contact tracing among patients with chronic renal failure

Author

Losi, M, Luppi, F, Gardenghi, L, Cerri, S, Roversi, P, Meacci, M, Meccugni, B, Rumpianesi, F, Fabbri, L, Richeldi, L, Losi M, Luppi F, Gardenghi L, Cerri S, Roversi P, Meacci M, Meccugni B, Rumpianesi F, Fabbri L, Richeldi L., Losi, M, Luppi, F, Gardenghi, L, Cerri, S, Roversi, P, Meacci, M, Meccugni, B, Rumpianesi, F, Fabbri, L, Richeldi, L, Losi M, Luppi F, Gardenghi L, Cerri S, Roversi P, Meacci M, Meccugni B, Rumpianesi F, Fabbri L, and Richeldi L.

Published
2008

42. Performance del test Quantiferon-TB Gold In-Tube in campioni biologici diversi dal sangue provenienti da diversi distretti corporei

Author

Losi M, Lo Cascio G, Meacci M, Peracchi M, Fallico L, Fabio A, Meccugni B, Apice M, Richeldi L, Rumpianesi F., DAL MONTE, PAOLA, LOMBARDI, GIULIA, Losi M, Dal Monte P, Lombardi G, Lo Cascio G, Meacci M, Peracchi M, Fallico L, Fabio A, Meccugni B, Apice M, Richeldi L, and Rumpianesi F

Subjects
QuantiferonTB, extrapulmonary tuberculosis, IFN GAMMA
Abstract

Introduzione: La diagnosi di tubercolosi extra-polmonare (e-TB) è difficoltosa a causa della bassa sensibilità dei metodi microbiologici tradizionali. I test per interferone-gamma (IFN-gamma) per la diagnosi di infezione tubercolare latente rappresentano potenziali test diagnostici più sensibili per la diagnosi di TB attiva. Metodi: il test QuantiFERON-TB Gold In-Tube (QFT-IT; Cellestis Ltd., Victoria, Australia) è stato eseguito su 31 campioni di liquidi biologici diversi dal sangue in pazienti con un alto sospetto clinico di e-TB. Risultati: nella nostra popolazione: 26 (83,9%) pazienti erano nati in Italia; 2 (6,5%) provenivano dal Ghana; 2 dall’India ed uno (3,2%) dalle Filippine; l’età media era 64,42 ± 20,30 anni; 4 (12,9%) individui erano BCG-vaccinati. Tre (9,7%) pazienti avevano una diagnosi di e-TB, mentre 28 (90,3%) erano affetti da una patologia non-tubercolare. I 31 campioni biologici esaminati comprendevano: 25 (80,6%) liquidi pleurici (LP), 3 (9,7%) liquidi ascitici e 3 BroncoLavaggi-Alveolari (BAL). Il test QFT-IT mostrava un risultato indeterminato in 5 (16,1%) campioni: 2 (6,4%) avevano elevati livelli di IFN-gamma nel controllo negativo. Nelle TB extra-polmonari: in 2 (66,7%) pazienti il test QFT-IT risultava indeterminato su LP; in un paziente il QFT-IT era positivo su liquido pleurico e negativo su sangue. Nei 28 pazienti con patologie non-tubercolari: 4 (12,9%) individui erano positivi al QFT-IT su campioni provenienti dalla sede di infezione e 5 (16,1%) su sangue. Il test QFT-IT mostrava una “performance” sui campioni biologici simile a quella su sangue: sensibilità 33,3% su campioni biologici vs 33,3% su sangue; specificità 85,7% su campioni biologici vs 82,1% su sangue. Conclusioni: questi risultati preliminari indicano che la “performance” del test QFT-IT su campioni biologici provenienti dalla sede di infezione potrebbe rappresentare un utile test per una accurata diagnosi di tubercolosi extra-polmonare. Ulteriori studi sono necessari per valutare la sensibilità dei test per IFN-gamma su campioni biologici diversi dal sangue.

Published
2011

43. Il test Quantiferon-TB Gold In-Tube nel bambino di eta’ inferiore a 5 anni: potenziale utilita’ clinica?

Author

LOMBARDI, GIULIA, DAL MONTE, PAOLA, PACE, ANTONELLA, BERNARDI, FILIPPO, LANDINI, MARIA PAOLA, Petrucci R, Corsini I, Losi M, Richeldi L, Lombardi G, Petrucci R, Dal Monte P, Corsini I, Pace A, Losi M, Richeldi L, Bernardi F, and Landini MP

Subjects
TUBERCOLOSI, BAMBINI, QuantiferonTB
Abstract

Introduzione: Poichè i tassi di progressione da infezione tubercolare latente (ITBL) a tubercolosi attiva (TB) sono più elevati nei neonati e nei bambini di età inferiore ai 5 anni, scopo di questo lavoro è stata la valutazione della “performance” del test QuantiFERON-TB Gold In-Tube (QFT-IT; Cellestis, Australia) rispetto al Test Cutaneo Tubercolinico (TCT) in questa popolazione. Metodi: Sono stati analizzati retrospetticamente 145 pazienti pediatrici di età inferiore ai 5 anni, stretti contatti di un caso indice di TB polmonare, ai quali erano stati eseguiti: il TCT (5UI Biocine Test PPD; Chiron, Siena), il test QFT-IT Risultati: La popolazione in studio (n= 145 bambini) era così caratterizzata: età media 2.5 ± 1.5 anni, 57.2% maschi, nati nell’86.9% dei casi in Italia, le cui famiglie provenivano rispettivamente da Paesi ad alta (56.6%), media (5.5%) e bassa (37.9%) endemia tubercolare. Su 145 bambini, il QFT è risultato positivo in 24 (16.6%), negativo in 112 (77.2%) e indeterminato in 9 casi (6.2%). Tra i 24 bambini con QFT-IT positivo, 13 avevano diagnosi di malattia, mentre 11 di ITBL. Su 112 dei 145 bambini analizzati è stato eseguito il TCT (positivo se >=10 mm) ed è stata calcolata la concordanza con il QFT, risultata dell’82.9% (k=0.52). Tra i risultati discordanti 12 erano TCT-positivi/QFT-IT-negativi, di cui 7 vaccinati, mentre 7 erano TCT-negativi/QFT-IT-positivi, di cui 3 casi con diagnosi di malattia e 4 con diagnosi di ITBL. Tra i 16 casi con entrambi i test positivi è stata valutata la distribuzione dei valori quantitativi espressi rispettivamente in mm per il TCT e in UI/ml di IFN-gamma per il QFT-IT e la diagnosi clinica (6 casi di ITBL e 10 di TB). Sette su 10 casi di malattia presentavano valori di IFN-gamma >10 UI/ml e un indurimento tra 10 e 15 mm; 3/6 casi di ITBL presentavano valori di IFN-gamma >10 UI/ml e un indurimento tra 11 e 20 mm. Conclusioni: Questi dati supportano l’utilizzo del test QFT-IT nei bambini di età inferiore ai 5 anni, ad oggi poco studiato.

Published
2011

44. Diagnosis of latent tuberculosis infection in patients with hematological malignancies: use of the new IFN-gamma-based blood tests

Author

Losi, M, Luppi, F, Cerri, S, Ferrari, A, D’Amico, R, Alfieri, P, Roversi, P, Meacci, M, Meccugni, B, Marchetti Dori, I, Pollastri, G, Pederzoli, F, Caracciolo, R, Marasca, R, Luppi, M, Torelli, G, Fabbri, L, Richeldi, L, Losi M, Luppi F, Cerri S, FERRARI, ANDREA, D’Amico R, Alfieri P, Roversi P, Meacci M, Meccugni B, Marchetti Dori I, Pollastri G, Pederzoli F, Caracciolo R, Marasca R, Luppi M, Torelli G, Fabbri LM, Richeldi L, Losi, M, Luppi, F, Cerri, S, Ferrari, A, D’Amico, R, Alfieri, P, Roversi, P, Meacci, M, Meccugni, B, Marchetti Dori, I, Pollastri, G, Pederzoli, F, Caracciolo, R, Marasca, R, Luppi, M, Torelli, G, Fabbri, L, Richeldi, L, Losi M, Luppi F, Cerri S, FERRARI, ANDREA, D’Amico R, Alfieri P, Roversi P, Meacci M, Meccugni B, Marchetti Dori I, Pollastri G, Pederzoli F, Caracciolo R, Marasca R, Luppi M, Torelli G, Fabbri LM, and Richeldi L

Published
2007

45. Monitoring the quality of laboratories and the prevalence of resistance to antituberculosis drugs: Italy, 1998–2000

Author

Migliori, G. B., Fattorini, L., Vaccarino, R., Besozzi, G., Saltini, C., Orefici, G., Iona, E., Matteelli, A., Fiorentini, F., Codecasa, L. R., Casali, Lucio, Cassone, A., De Santis, A., Giorgio, V., Vinciguerra, P., Angarano, G., Petrozzi, L., Costa, D., Gozzellino, F., Perboni, A., Marchetti, D., Pascali, A., Falcone, F., Mariano, V., Rizza, F., Pretto, P., Turano, A., Carosi, G. P., Farris, A. G., Ligia, G. P., Orani, G., Farris, B., Foschi, C., Trucco, G., Aiolfi, S., Ceruti, T., Parpanesi, M., Calabro, S., Felisatti, G., Tortoli, E., Nutini, S., Montini, G., D'Ambrosio, V., Ceraminiello, A., Bernorio, S., Buono, L., Montesano, P., Vinci, E., Sabato, E., Gamba, S., Crepaldi, P., Magliano, E., Penati, V., Vaccarino, P., Astolfi, A., Bertoli, G., Rupianesi, F., Losi, M., Richeldi, L., Ferrara, Giovanni, Minuccio, E., Napolitano, G., Molinari, G. L., Saini, L., Garzone, A., Vertuccio, C., Marcias, S., Menozzi, M., Marone, P., Peona, V., Nascimbene, C., Pasi, A., Cascina, A., Monaco, A., Penza, O., Pasticci, Maria Bruna, Bistoni, F., Sposini, T., Colorizio, V., Confalonieri, M., Bottrighi, P., Macor, G., Moretti, G., Fatigante, R., Barbaro, A., Agati, G., Zaccara, F., Viola, S., Le Donne, R., Farinelli, G., Mancini, D., Ermeti, M., Longi, R., Tronci, M., Bisetti, A., Altieri, A., and Fadda, G.

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, Prevalence of resistance, Drug Resistance, Antitubercular Agents, Drug resistance, Proficiency testing, Drug, Immigrant, Susceptibility testing, Emigration and Immigration, Humans, Italy, Laboratories, Prevalence, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Internal medicine, medicine, Ethambutol, business.industry, Public health, Isoniazid, Bacterial, Multidrug-Resistant, medicine.disease, Surgery, Streptomycin, business, Multiple, Rifampicin, medicine.drug
Abstract

In 1998 a network of 20 regional tuberculosis (TB) laboratories (the Italian Multicentre Study on Resistance to Antituberculosis drugs (SMIRA) network) was established in Italy to implement proficiency testing and to monitor the prevalence of drug resistance nationwide. The network managed 30% of all TB cases reported in Italy each year. The aim of the present report is to describe: 1) the accuracy of drug-susceptibility testing in the network; 2) the prevalence of drug resistance for the period 1998-2000. Data were collected from the network laboratories. Sensitivity to streptomycin and ethambutol increased from the first survey (1998-1999) to the second survey (2000) from 87.7 to 91.9%. Specificity, predictive values for resistance and susceptibility, efficiency and reproducibility were consistent in both surveys. In previously untreated cases, the prevalence of multidrug-resistance was the same in both surveys (1.2%), while a slight decrease from the first to the second survey was observed for monoresistance to rifampicin (from 0.8 to 0.4%) and isoniazid (from 2.9 to 2%). The significant association found between isoniazid resistance and immigration is a useful indicator for both clinicians managing individual tuberculosis cases and public health services planning control strategies.

Published
2003
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46. Mancanza di correlazione tra segni radiologici di tubercolosi inattiva e risposta immune specifica nei confronti di M. Tuberculosis in pazienti con malattie ematolinfoproliferative

Author

Fantini R, Losi M, Ferrari A, Luppi F, Spagnolo P, D'Amico R, Torricelli P, Fiocchi F, Roversi P, Cerri S, Rumpianesi F, Meacci M, Meccugni B, Fabbri LM. Torelli G, Luppi M, Richeldi L., Fantini, R, Losi, M, Ferrari, A, Luppi, F, Spagnolo, P, D'Amico, R, Torricelli, P, Fiocchi, F, Roversi, P, Cerri, S, Rumpianesi, F, Meacci, M, Meccugni, B, Fabbri LM., T, Luppi, M, and Richeldi, L

Subjects
Malattie ematolinfoproliferative, Tuberculosis, IFN-gamma based tests
Published
2010

47. Use of Quantiferon-TB in tube test in the diagnosis of non tuberculous mycobacteria lung disease

Author

Losi M, Fabio A, Dal Monte P, Peracchi M, Del Giovane P, Meacci M, Luppi F, Cerri S, Lombardi G, Fallico L, Apice MG, Spagnolo P, Rumpianesi F, Manganelli R, Fabbri LM, Richeldi L., Losi, M, Fabio, A, Dal Monte, P, Peracchi, M, Del Giovane, P, Meacci, M, Luppi, F, Cerri, S, Lombardi, G, Fallico, L, Apice, M, Spagnolo, P, Rumpianesi, F, Manganelli, R, Fabbri, L, and Richeldi, L

Subjects
Non tuberculous mycobacteria, Interferon-gamma based test
Published
2010

48. Diagnosis of latent tuberculosis in children immigrants from countries with high tuberculosis prevalence

Author

Bergamini, BM, Losi, M, Del Giovane, C, Meacci, M, Luppi, F, Venturelli, C, D’Amico, R, Spagnolo, P, Meccugni, B, Cerri, S, Codifava, M, Rumpianesi, F, Paolucci, P, Fabbri, LM, Richeldi, L, Bergamini, B, Losi, M, Del Giovane, C, Meacci, M, Luppi, F, Venturelli, C, D’Amico, R, Spagnolo, P, Meccugni, B, Cerri, S, Codifava, M, Rumpianesi, F, Paolucci, P, Fabbri, L, and Richeldi, L

Subjects
Latent tuberculosis infection, children immigrants
Published
2010

49. Chiusura transcatetere percutanea di un difetto interatriale tipo forame ovale guidata con ecocardiografia intracardiaca in una paziente anziana

Author

Losi, M., Pirozzi, Flora, Cavallaro, G., De Rosa, R., PIROZZI, FLORA, RAPACCIUOLO, ANTONIO, PISCIONE, FEDERICO, Losi, M., Pirozzi, Flora, Cavallaro, G., De Rosa, R., Rapacciuolo, Antonio, and Piscione, Federico

Subjects
Aging, Percutaneous transcatheter closure, Intracardiac echocardiography, Geriatrics and Gerontology, Interatrial septal defect
Abstract

Intracardiac echocardiography guidance is replacing transesophageal echocardiography for percutaneous transcatheter closure of atrial septal defects eliminating the risks of endotracheal and esophageal intubation with a reduced procedure length. This case demonstrate that intracardiac echocardiography allows the correct Amplatzer disks implantation with percutaneous catheter closure in an elderly patient with short interventional times.

Published
2009

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