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1. Prognostic Impact of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Results on Survival in COVID-19 Intensive Care Unit Patients: a Post Hoc Analysis from the European Confederation of Medical Mycology (ECMM) COVID-19-Associated Pulmonary Aspergillosis Study

Author

Giacobbe, Daniele Roberto, Prattes, Juergen, Wauters, Joost, Dettori, Silvia, Signori, Alessio, Salmanton-García, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Klimko, Nikolay, Shadrivova, Olga, Cornely, Oliver A, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, Bassetti, Matteo, and Hoenigl, Martin

Subjects
Infectious Diseases, Rare Diseases, Lung, Good Health and Well Being, Aspergillus, Bronchoalveolar Lavage Fluid, COVID-19, Critical Illness, Galactose, Humans, Intensive Care Units, Invasive Pulmonary Aspergillosis, Mannans, Mycology, Prognosis, Pulmonary Aspergillosis, Sensitivity and Specificity, CAPA, GM, biomarker, galactomannan, BALF, ECMM-CAPA Study Group, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology
Abstract

Critically ill patients with coronavirus disease 2019 (COVID-19) may develop COVID-19-associated pulmonary aspergillosis (CAPA), which impacts their chances of survival. Whether positive bronchoalveolar lavage fluid (BALF) mycological tests can be used as a survival proxy remains unknown. We conducted a post hoc analysis of a previous multicenter, multinational observational study with the aim of assessing the differential prognostic impact of BALF mycological tests, namely, positive (optical density index of ≥1.0) BALF galactomannan (GM) and positive BALF Aspergillus culture alone or in combination for critically ill patients with COVID-19. Of the 592 critically ill patients with COVID-19 enrolled in the main study, 218 were included in this post hoc analysis, as they had both test results available. CAPA was diagnosed in 56/218 patients (26%). Most cases were probable CAPA (51/56 [91%]) and fewer were proven CAPA (5/56 [9%]). In the final multivariable model adjusted for between-center heterogeneity, an independent association with 90-day mortality was observed for the combination of positive BALF GM and positive BALF Aspergillus culture in comparison with both tests negative (hazard ratio, 2.53; 95% CI confidence interval [CI], 1.28 to 5.02; P = 0.008). The other independent predictors of 90-day mortality were increasing age and active malignant disease. In conclusion, the combination of positive BALF GM and positive BALF Aspergillus culture was associated with increased 90-day mortality in critically ill patients with COVID-19. Additional study is needed to explore the possible prognostic value of other BALF markers.

Published
2022

2. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert

Published
2023
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4. Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients—a multinational observational study by the European Confederation of Medical Mycology

Author

Debaveye, Yves, Miceli, Marisa H., Tudesq, Jean-Jacques, Paul, Gregor, Krause, Robert, Linhofer, Marina, Frost, Jonas, Zechner, Peter, Kochanek, Matthias, Eller, Philipp, Jenks, Jeffrey D., Volpi, Sara, Bellanger, Anne-Pauline, White, P.Lewis, Goldman, Gustavo H., Bowyer, Paul, Rokas, Antonis, Gago, Sara, Pelosi, Paolo, Robba, Chiara, Gangneux, Jean-Pierre, Lass-Floerl, Cornelia, Machado, Marina, Muñoz, Patricia, Prattes, Juergen, Wauters, Joost, Giacobbe, Daniele Roberto, Salmanton-García, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Reisinger, Alexander Christian, Cornely, Oliver A., Lahmer, Tobias, Valerio, Maricela, Delhaes, Laurence, Jabeen, Kauser, Steinmann, Joerg, Chamula, Mathilde, Bassetti, Matteo, Hatzl, Stefan, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, and Hoenigl, Martin

Published
2022
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5. Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.

Author

Taccone, Fabio Silvio, Rynkowski Bittencourt, Carla, Møller, Kirsten, Lormans, Piet, Quintana-Díaz, Manuel, Caricato, Anselmo, Cardoso Ferreira, Marco Antonio, Badenes, Rafael, Kurtz, Pedro, Søndergaard, Christian Baastrup, Colpaert, Kirsten, Petterson, Leticia, Quintard, Herve, Cinotti, Raphael, Gouvêa Bogossian, Elisa, Righy, Cassia, Silva, Serena, Roman-Pognuz, Erik, Vandewaeter, Catherine, and Lemke, Daniel

Abstract

Key Points: Question: How does use of a liberal or restrictive strategy of blood transfusion influence neurological outcome among patients with acute brain injury? Findings: In this randomized clinical trial that included 850 patients with acute brain injury and a hemoglobin level below 9 g/dL, those who were treated with a liberal transfusion strategy triggered by hemoglobin below 9 g/dL had a lower probability of unfavorable neurological outcome at 180 days than those treated with a restrictive strategy triggered by hemoglobin below 7 g/dL (62.6% vs 72.6%, respectively; adjusted relative risk, 0.86). Meaning: A liberal transfusion strategy compared with a restrictive strategy resulted in a lower rate of unfavorable neurological outcome among patients with acute brain injury. Importance: Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective: To assess the impact on neurological outcome of 2 different hemoglobin thresholds to guide red blood cell transfusions in patients with acute brain injury. Design, Setting, and Participants: Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted in 72 intensive care units across 22 countries. Eligible patients had traumatic brain injury, aneurysmal subarachnoid hemorrhage, or intracerebral hemorrhage; hemoglobin values below 9 g/dL within the first 10 days after injury; and an expected intensive care unit stay of at least 72 hours. Enrollment occurred between September 1, 2017, and December 31, 2022. The last day of follow-up was June 30, 2023. Interventions: Eight hundred fifty patients were randomly assigned to undergo a liberal (transfusion triggered by hemoglobin <9 g/dL; n = 408) or a restrictive (transfusion triggered by hemoglobin <7 g/dL; n = 442) transfusion strategy over a 28-day period. Main Outcomes and Measures: The primary outcome was occurrence of an unfavorable neurological outcome, defined as a Glasgow Outcome Scale Extended score between 1 and 5, at 180 days following randomization. There were 14 prespecified serious adverse events, including occurrence of cerebral ischemia after randomization. Results: Among 820 patients who completed the trial (mean age, 51 years; 376 [45.9%] women), 806 had available data on the primary outcome, 393 in the liberal strategy group and 413 in the restrictive strategy group. The liberal strategy group received a median of 2 (IQR, 1-3) units of blood, and the restrictive strategy group received a median of 0 (IQR, 0-1) units of blood, with an absolute mean difference of 1.0 unit (95% CI, 0.87-1.12 units). At 180 days after randomization, 246 patients (62.6%) in the liberal strategy group had an unfavorable neurological outcome compared with 300 patients (72.6%) in the restrictive strategy group (absolute difference, −10.0% [95% CI, −16.5% to −3.6%]; adjusted relative risk, 0.86 [95% CI, 0.79-0.94]; P =.002). The effect of the transfusion thresholds on neurological outcome at 180 days was consistent across prespecified subgroups. In the liberal strategy group, 35 (8.8%) of 397 patients had at least 1 cerebral ischemic event compared with 57 (13.5%) of 423 in the restrictive strategy group (relative risk, 0.65 [95% CI, 0.44-0.97]). Conclusions and Relevance: Patients with acute brain injury and anemia randomized to a liberal transfusion strategy were less likely to have an unfavorable neurological outcome than those randomized to a restrictive strategy. Trial Registration: ClinicalTrials.gov Identifier: NCT02968654 This randomized clinical trial assesses the effect of a liberal vs a restrictive hemoglobin threshold for red blood cell transfusion on unfavorable neurological outcome in patients with acute brain injury. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Brain injury and ketamine study (BIKe): a prospective, randomized controlled double blind clinical trial to study the effects of ketamine on Therapy Intensity Level and intracranial pressure in severe traumatic injury patients.

Author

De Sloovere, Veerle Tineke, primary, Mebis, Liese, additional, Wouters, Pieter, additional, Grandas, Fabian Guïza, additional, Boonen, Eva, additional, Bourgeois, Marc, additional, Dubois, Jasperina, additional, Ledoux, Didier, additional, Lormans, Piet, additional, Maréchal, Hugues, additional, Hauwaert, Emmanuel Van der, additional, Depreitere, Bart, additional, and Meyfroidt, Geert, additional

Published
2024
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7. Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis

Author

Janssen, Nico A.F., Nyga, Remy, Vanderbeke, Lore, Jacobs, Cato, Ergun, Mehmet, Buil, Jochem B., van Dijk, Karin, Altenburg, Josje, Bouman, Catherine S.C., van der Spoel, Hans I., Rijnders, Bart J.A., Dunbar, Albert, Schouten, Jeroen A., Lagrou, Katrien, Bourgeois, Marc, Reynders, Marijke, van Regenmortel, Niels, Rutsaert, Lynn, Lormans, Piet, Feys, Simon, Debavaye, Yves, Tamion, Fabienne, Costa, Damien, Maizel, Julien, Dupont, Herve, Chouaki, Taieb, Nseir, Saad, Sendid, Boualem, Bruggemann, Roger J.M., van de Veerdonk, Frank L., Wauters, Joost, and Verweij, Paul E.

Subjects
Pulmonary aspergillosis -- Statistics -- Risk factors -- Patient outcomes, Intensive care units -- Statistics, Hospital patients -- Statistics, Health
Abstract

Incidence of coronavirus disease (COVID-19)associated pulmonary aspergillosis (CAPA) in hospital intensive care units (ICUs) is 3.8%-33.3% (1-9). Variations might be explained by differences in patient populations and CAPA definitions used, [...]

Published
2021
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9. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, primary, De Piero, Maria Elena, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Folliguet, Thierry, additional, Taccone, Fabio Silvio, additional, Camporota, Luigi, additional, Swol, Justyna, additional, Wiedemann, Dominik, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Vuylsteke, Alain, additional, Kassif, Yigal, additional, Scandroglio, Anna Mara, additional, Fanelli, Vito, additional, Gaudard, Philippe, additional, Ledot, Stephane, additional, Barker, Julian, additional, Boeken, Udo, additional, Maier, Sven, additional, Kersten, Alexander, additional, Meyns, Bart, additional, Pozzi, Matteo, additional, Pedersen, Finn M, additional, Schellongowski, Peter, additional, Kirali, Kaan, additional, Barrett, Nicholas, additional, Riera, Jordi, additional, Mueller, Thomas, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Lo Coco, Valeria, additional, Van der Horst, Iwan C C, additional, Van Bussel, Bas C T, additional, Schnabel, Ronny M, additional, Delnoij, Thijs, additional, Bolotin, Gil, additional, Lorini, Luca, additional, Schmiady, Martin O, additional, Schibilsky, David, additional, Kowalewski, Mariusz, additional, Pinto, Luis F, additional, Silva, Pedro E, additional, Kornilov, Igor, additional, Blandino Ortiz, Aaron, additional, Vercaemst, Leen, additional, Finney, Simon, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Hennig, Felix, additional, Antonini, Marta Velia, additional, Davidson, Mark, additional, Jones, Tim J, additional, Staudinger, Thomas, additional, Mair, Peter, additional, Kilo, Juliane, additional, Krapf, Christoph, additional, Erbert, Kathrin, additional, Peer, Andreas, additional, Bonaros, Nikolaos, additional, Kotheletner, Florian, additional, Krenner Mag, Niklas, additional, Shestakova, Liana, additional, Hermans, Greet, additional, Dauwe, Dieter, additional, Meersseman, Philippe, additional, Stockman, Bernard, additional, Nobile, Leda, additional, Lhereux, Olivier, additional, Nrasseurs, Alexandre, additional, Creuter, Jacques, additional, De Backer, Daniel, additional, Giglioli, Simone, additional, Michiels, Gregoire, additional, Foulon, Pierre, additional, Raes, Matthias, additional, Rodrigus, Inez, additional, Allegaert, Matthias, additional, Jorens, Philippe, additional, Debeucklare, Gerd, additional, Piagnarelli, Michael, additional, Biston, Patrick, additional, Peperstraete, Harlinde, additional, Vandewiele, Komeel, additional, Germay, Olivier, additional, Vandeweghe, Dimitri, additional, Havrin, Sven, additional, Bourgeois, Marc, additional, Lagny, Marc-Gilbert, additional, Alois, Genette, additional, Lavios, Nathalie, additional, Misset, Benoit, additional, Courcelle, Romain, additional, Timmermans, Philippe J, additional, Yilmaz, Alaaddin, additional, Vantomout, Michiel, additional, Lehaen, Jerone, additional, Jassen, Ame, additional, Guterman, Herbert, additional, Strauven, Maarten, additional, Lormans, Piet, additional, Verhamme, Bruno, additional, Vandewaeter, catherine, additional, Bonte, Frederik, additional, Vionne, Dominique, additional, Balik, Martin, additional, Blàha, Jan, additional, Lips, Michal, additional, Othal, Michal, additional, Bursa, Filip, additional, Spacek, Radim, additional, Christensen, Steffen, additional, Jorgensen, Vibeke, additional, Sorensen, Marc, additional, Madsen, Soren A, additional, Puss, Severin, additional, Beljantsev, Aleksandr, additional, Saiydoun, gabriel, additional, Fiore, Antonio, additional, Colson, Pascal, additional, Bazalgette, Florian, additional, Capdevila, Xavier, additional, Kollen, Sebastien, additional, Muller, Laurent, additional, Obadia, Jean-Francois, additional, Dubien, Pierre-Yves, additional, Ajrhourh, Lucrezia, additional, Guinot, Pierre G, additional, Zarka, Jonathan, additional, Besserve, Patricia, additional, Malfertheiner, Maximilian V, additional, Dreier, Esther, additional, Heinze, Birgit, additional, Akhyari, Payam, additional, Lichtenberg, Artur, additional, Aubin, Hug, additional, Assman, Alexander, additional, Saeed, Diyar, additional, Thiele, Holger, additional, Baumgaertel, Matthias, additional, Schmitto, Jan D, additional, Ruslan, Natanov, additional, Haverich, Axel, additional, Thielmann, Matthias, additional, Brenner, Thorsten, additional, Ruhpawar, Arjang, additional, Benk, Christoph, additional, Czerny, Martin, additional, Staudacher, Dawid L, additional, Beyersdorf, Fridhelm, additional, Kalbhenn, Johannes, additional, Henn, Philipp, additional, Popov, Aron-Frederik, additional, Iuliu, Torje, additional, Muellenbach, Ralf, additional, Reyher, Christian, additional, Rolfes, Caroline, additional, Lotz, Gosta, additional, Sonntagbauer, Michael, additional, Winkels, Helen, additional, Fichte, Julia, additional, Stohr, Robert, additional, Kalverkamp, Sebastian, additional, Karagiannidis, Christian, additional, Schafer, Simone, additional, Svetlitchny, Alexei, additional, Hopf, Hans-Bernd, additional, Jarczak, Dominik, additional, Groesdonk, Heinirich, additional, Rommer, Magdalena, additional, Hirsch, Jan, additional, Kaehny, Christian, additional, Soufleris, Dimitros, additional, Gavriilidis, Georgios, additional, Pontikis, Kostantinos, additional, Kyriakopoulou, Magdalini, additional, Kyriakoudi, Anna, additional, O'Brien, Serena, additional, Conrick-Martin, Ian, additional, Carton, Edmund, additional, Makhoul, Maged, additional, Ben-Ari, Josef, additional, Hadash, Amir, additional, Kogan, Alexander, additional, Kassif Lerner, Reut, additional, Abu-Shakra, Anas, additional, Matan, Moshe, additional, Balawona, Ahmad, additional, Kachel, Erez, additional, Altshuler, Roman, additional, Galante, Ori, additional, Fuchs, Lior, additional, Almog, Yaniv, additional, Ishay, Yaron S, additional, Lichter, Yael, additional, Gal-oz, Amir, additional, Carmi, Uri, additional, Nini, Asaph, additional, Soroksky, Arie, additional, Dekel, Hagi, additional, Rozman, Ziv, additional, Tayem, Emad, additional, Ilgiyaev, Eduard, additional, Hochman, Yuval, additional, Miltau, daniel, additional, Rapoport, Avigal, additional, Eden, Arieh, additional, Kompanietz, Dmitry, additional, Yousif, Michael, additional, Golos, Miri, additional, Grazioli, Lorenzo, additional, Ghitti, Davide, additional, Loforte, Antonio, additional, Di Luca, Daniela, additional, Baiocchi, Massimo, additional, Pacini, Davide, additional, Cappai, Antioco, additional, Meani, Paolo, additional, Mondino, Michele, additional, Russo, Claudio F, additional, Ranucci, Marco, additional, Fina, Dario, additional, Cotza, Marco, additional, Ballotta, Andrea, additional, Landoni, Giovanni, additional, Nardelli, Pasquale, additional, Fominski, Eygeny V, additional, Brazzi, Luca, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Simonetti, Umberto, additional, Livigni, Sergio, additional, Silengo, Daniela, additional, Arena, Giulia, additional, Sovatzis, Stefania S, additional, Degani, Antonella, additional, Riccardi, Mariachiara, additional, Milanesi, Elisa, additional, Raffa, Giuseppe, additional, Martucci, Gennaro, additional, Arcadipane, Antonio, additional, Panarello, Giovanna, additional, Chiarini, Giovanni, additional, Cattaneo, Sergio, additional, Puglia, Carmine, additional, Benussi, Stefano, additional, Foti, Giuseppe, additional, Giani, Marco, additional, Bombino, Michela, additional, Costa, Maria Cristina, additional, Rona, Roberto, additional, Avalli, Leonello, additional, Donati, Abele, additional, Carozza, Roberto, additional, Gasparri, Francesco, additional, Carsetti, Andrea, additional, Picichè, Marco, additional, Marinello, Anna, additional, Danzi, Vinicio, additional, Zanin, Anita, additional, Condello, Ignazio, additional, Fiore, Flavio, additional, Moscarelli, Marco, additional, Nasso, Giuseppe, additional, Speziale, Giuseppe, additional, Sandrelli, Luca, additional, Montalto, Andrea, additional, Musumeci, Francesco, additional, Circelli, Alessandro, additional, Russo, Emanuele, additional, Agnoletti, Vanni, additional, Rociola, Ruggero, additional, Milano, Aldo D, additional, Pilato, Emanuele, additional, Comentale, Giuseppe, additional, Montisci, Andrea, additional, Alessandri, Francesco, additional, Tosi, Antonella, additional, Pugliese, Francesco, additional, Giordano, Giovanni, additional, Carelli, Simone, additional, Grieco, Domenico L, additional, Dell'Anna, Antonio M, additional, Antonelli, Massimo, additional, Ramoni, Enrico, additional, Zulueta, Josè, additional, Del Giglio, Mauro, additional, Petracca, Sebastiano, additional, Bertini, Pietro, additional, Guarracino, Fabio, additional, De Simone, Luigi, additional, Angeletti, Paolo M, additional, Forfori, Francesco, additional, Taraschi, Francesco, additional, Quintiliani, Veronica N, additional, Samalavicius, Robertas, additional, Jankuviene, Agne, additional, Scupakova, Nadezda, additional, Urbonas, Karolis, additional, Kapturauskas, Juozas, additional, Soerensen, Gro, additional, Suwalski, Piotr, additional, Linhares Santos, Luis, additional, Marques, Ana, additional, Miranda, Marisa, additional, Teixeira, Sonia, additional, Salgueiro, Andrea, additional, Pereira, Filipe, additional, Ketskalo, Michail, additional, Tsarenko, Sergey, additional, Shilova, Alexandra, additional, Afukov, Ivan, additional, Popugaev, Konstantin, additional, Minin, Sergei, additional, Shelukhin, Daniil, additional, Malceva, Olga, additional, Gleb, Moroz, additional, Skopets, Alexander, additional, Kornelyuk, Roman, additional, Kulikov, Alexandr, additional, Okhrimchuk, Vadim, additional, Turchaninov, Alexandr, additional, Petrushin, Maxim, additional, Sheck, Anastasia, additional, Mekulov, Akhmed, additional, Ciryateva, Svetlana, additional, Urusov, Dmitry, additional, Gorjup, Vojka, additional, Golicnik, Alenka, additional, Goslar, Tomaz, additional, Ferrer, Ricard, additional, Martinez-Martinez, Maria, additional, Argudo, Eduard, additional, Palmer, Neiser, additional, De Pablo Sanchez, Raul, additional, Juan Higuera, Lucas, additional, Arnau Blasco, Lucas, additional, Marquez, Josè A, additional, Sbraga, Fabrizio, additional, Fuset, Mari Paz, additional, De Gopegui, Pablo Ruiz, additional, Claraco, Luis M, additional, De Ayala, Josè A, additional, Peiro, Maranta, additional, Ricart, Pilar, additional, Martinez, Sergio, additional, Chavez, Fernando, additional, Fabra, Marc, additional, Sandoval, elena, additional, Toapanta, David, additional, Carraminana, Albert, additional, Tellez, Adrian, additional, Ososio, Jeysson, additional, Milan, Pablo, additional, Rodriguez, Jorge, additional, Andoni, Garcia, additional, Gutierrez, Carola, additional, Perez de la Sota, Enrique, additional, Eixeres-Esteve, Andrea, additional, Garcia-Maellas, Maria Teresa, additional, Gutierrez-Gutierrez, Judit, additional, Arboleda-Salazar, Rafael, additional, Santa Teresa, Patricia, additional, Jaspe, Alexis, additional, Garrido, Alberto, additional, Castaneda, Galo, additional, Alcantara, Sara, additional, Martinez, Nuria, additional, Perez, Marina, additional, Villanueva, Hector, additional, Vidal Gonzalez, Anxela, additional, Paez, Juan, additional, Santon, Arnoldo, additional, Perez, Cesar, additional, Lopez, Marta, additional, Rubio Lopez, Maria Isabel, additional, Gordillo, Antonio, additional, Naranjo-Izurieta, Jose, additional, Munoz, Javier, additional, Alcalde, Immaculada, additional, Onieva, Fernando, additional, Gimeno Costa, Ricardo, additional, Perez, Francisco, additional, Madrid, Isabel, additional, Gordon, Monica, additional, Albacete Moreno, Carlos L, additional, Perez, Daniel, additional, Lopez, Nayara, additional, Martinenz, Domingo, additional, Blanco-Schweizer, Pablo, additional, Diez, Cristina, additional, Perez, David, additional, Prieto, Ana, additional, Renedo, Gloria, additional, Bustamante, Elena, additional, Cicuendez, Ramon, additional, Citores, Rafael, additional, Boado, Victoria, additional, Garcia, Katherine, additional, Voces, Roberto, additional, Domezain, Monica, additional, Nunez Martinez, Jose Maria, additional, Vicente, Raimundo, additional, Martin, David, additional, Andreu, Antonio, additional, Gomez Casal, Vanesa, additional, Chico, Ignacio, additional, Menor, Eva Maria, additional, Vara, Sabela, additional, Gamacho, Jose, additional, Perez-Chomon, Helen, additional, Javier Gonzales, Francisco, additional, Barrero, Irene, additional, Martin-Villen, Luis, additional, Fernandez, Esperanza, additional, Mendoza, Maria, additional, Navarro, Joaquin, additional, Colomina Climent, Joaquin, additional, Gonzales-Perez, Alfredo, additional, Muniz-Albaceita, Guillermo, additional, Amado, Laura, additional, Rodriguez, Raquel, additional, Ruiz, Emilio, additional, Eiras, Maria, additional, Grins, Edgars, additional, Magnus, Rosen, additional, Kanetoft, Mikael, additional, Eidevald, Marcus, additional, Watson, Pia, additional, Vogt, Paul R, additional, Steiger, Peter, additional, Aigner, Tobias, additional, Weber, Alberto, additional, Grunefelder, Jurg, additional, Kunz, Martin, additional, Grapow, Martin, additional, Aymard, Thierry, additional, Reser, Diana, additional, Agus, Gianluca, additional, Consiglio, Jolanda, additional, Haenggi, Matthias, additional, Hansjoerg, Jenni, additional, Iten, Manuela, additional, Doeble, Thomas, additional, Zenklusen, Urs, additional, Bechtold, Xavier, additional, Faedda, Giovanni, additional, Iafrate, Manuel, additional, Rohjer, Amanda, additional, Bergamaschi, Layla, additional, Maessen, Jos, additional, Reis Miranda, Dinis, additional, Endeman, H, additional, Gommers, D, additional, Meuwese, C, additional, Maas, Jacinta, additional, Van Gijlswijk, MJ, additional, Van Berg, RN, additional, Candura, Dario, additional, Van der Linden, Marcel, additional, Kant, Merijin, additional, Van der Heijden, JJ, additional, Scholten, Eric, additional, Van Belle-van Haren, Nicole, additional, Lagrand, WK, additional, Vlaar, Alexander P, additional, De Jong, Syste, additional, Cander, Basar, additional, Sargin, Murat, additional, Ugur, Murat, additional, Kaygin, Mehmet A, additional, Daly, Kathleen, additional, Agnew, Nicola, additional, Head, Laura, additional, Kelly, Laura, additional, Anoma, Gunawardena, additional, Russell, Clare, additional, Aquino, Verna, additional, Scott, Ian, additional, Flemming, Lucy, additional, Gillon, Stuart, additional, Moore, Olivia, additional, Gelandt, Elton, additional, Auzinger, George, additional, Patel, Sameer, additional, and Loveridge, Robert, additional

Published
2022
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10. Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients-a multinational observational study by the European Confederation of Medical Mycology

Author

Prattes, Juergen, Wauters, Joost, Giacobbe, Daniele Roberto, Salmanton-Garcia, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Reisinger, Alexander Christian, Cornely, Oliver A., Lahmer, Tobias, Valerio, Maricela, Delhaes, Laurence, Jabeen, Kauser, Steinmann, Joerg, Chamula, Mathilde, Bassetti, Matteo, Hatzl, Stefan, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, Hoenigl, Martin, Prattes, Juergen, Wauters, Joost, Giacobbe, Daniele Roberto, Salmanton-Garcia, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Reisinger, Alexander Christian, Cornely, Oliver A., Lahmer, Tobias, Valerio, Maricela, Delhaes, Laurence, Jabeen, Kauser, Steinmann, Joerg, Chamula, Mathilde, Bassetti, Matteo, Hatzl, Stefan, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, and Hoenigl, Martin

Abstract

Objectives: Coronavirus disease 2019 (COVID-19) -associated pulmonary aspergillosis (CAPA) has emerged as a complication in critically ill COVID-19 patients. The objectives of this multinational study were to determine the prevalence of CAPA in patients with COVID-19 in intensive care units (ICU) and to investigate risk factors for CAPA as well as outcome. Methods: The European Confederation of Medical Mycology (ECMM) conducted a multinational study including 20 centres from nine countries to assess epidemiology, risk factors and outcome of CAPA. CAPA was defined according to the 2020 ECMM/ISHAM consensus definitions. Results: A total of 592 patients were included in this study, including 11 (1.9%) patients with histologically proven CAPA, 80 (13.5%) with probable CAPA, 18 (3%) with possible CAPA and 483 (81.6%) without CAPA. CAPA was diagnosed a median of 8 days (range 0-31 days) after ICU admission predominantly in older patients (adjusted hazard ratio (aHR) 1.04 per year; 95% CI 1.02-1.06) with any form of invasive respiratory support (HR 3.4; 95% CI 1.84-6.25) and receiving tocilizumab (HR 2.45; 95% CI 1.41-4.25). Median prevalence of CAPA per centre was 10.7% (range 1.7%-26.8%). CAPA was associated with significantly lower 90-day ICU survival rate (29% in patients with CAPA versus 57% in patients without CAPA; Mantel-Byar p < 0.001) and remained an independent negative prognostic variable after adjusting for other predictors of survival (HR 2.14; 95% CI 1.59-2.87, p <= 0.001). Conclusion: Prevalence of CAPA varied between centres. CAPA was significantly more prevalent among older patients, patients receiving invasive ventilation and patients receiving tocilizumab, and was an independent strong predictor of ICU mortality. (C) 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Published
2022

11. Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA‐FLU study

Author

Van Daele, Ruth, primary, Wauters, Joost, additional, Dreesen, Erwin, additional, Boelens, Jerina, additional, Nulens, Eric, additional, Lormans, Piet, additional, Vanderbeke, Lore, additional, Jacobs, Cato, additional, Rijnders, Bart, additional, Verweij, Paul E., additional, Brüggemann, Roger J., additional, and Spriet, Isabel, additional

Published
2022
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12. Risk factors and outcome of pulmonary aspergillosis in critically ill coronavirus disease 2019 patients—a multinational observational study by the European Confederation of Medical Mycology

Author

Prattes, Juergen, primary, Wauters, Joost, additional, Giacobbe, Daniele Roberto, additional, Salmanton-García, Jon, additional, Maertens, Johan, additional, Bourgeois, Marc, additional, Reynders, Marijke, additional, Rutsaert, Lynn, additional, Van Regenmortel, Niels, additional, Lormans, Piet, additional, Feys, Simon, additional, Reisinger, Alexander Christian, additional, Cornely, Oliver A., additional, Lahmer, Tobias, additional, Valerio, Maricela, additional, Delhaes, Laurence, additional, Jabeen, Kauser, additional, Steinmann, Joerg, additional, Chamula, Mathilde, additional, Bassetti, Matteo, additional, Hatzl, Stefan, additional, Rautemaa-Richardson, Riina, additional, Koehler, Philipp, additional, Lagrou, Katrien, additional, Hoenigl, Martin, additional, Debaveye, Yves, additional, Miceli, Marisa H., additional, Tudesq, Jean-Jacques, additional, Paul, Gregor, additional, Krause, Robert, additional, Linhofer, Marina, additional, Frost, Jonas, additional, Zechner, Peter, additional, Kochanek, Matthias, additional, Eller, Philipp, additional, Jenks, Jeffrey D., additional, Volpi, Sara, additional, Bellanger, Anne-Pauline, additional, White, P.Lewis, additional, Goldman, Gustavo H., additional, Bowyer, Paul, additional, Rokas, Antonis, additional, Gago, Sara, additional, Pelosi, Paolo, additional, Robba, Chiara, additional, Gangneux, Jean-Pierre, additional, Lass-Floerl, Cornelia, additional, Machado, Marina, additional, and Muñoz, Patricia, additional

Published
2022
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13. Additional file 1 of Acute kidney injury in critical COVID-19: a multicenter cohort analysis in seven large hospitals in Belgium

Author

Schaubroeck, Hannah, Vandenberghe, Wim, Boer, Willem, Boonen, Eva, Dewulf, Bram, Bourgeois, Camille, Dubois, Jasperina, Dumoulin, Alexander, Fivez, Tom, Gunst, Jan, Hermans, Greet, Lormans, Piet, Meersseman, Philippe, Mesotten, Dieter, Stessel, Björn, Vanhoof, Marc, De Vlieger, Greet, and Hoste, Eric

Abstract

Additional file 1. COVID-AKI-Belgium.

Published
2022
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16. Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry

Author

Prattes, Juergen, Wauters, Joost, Giacobbe, Daniele Roberto, Lagrou, Katrien, Hoenigl, Martin, Koehler, Philipp, Salmanton-garcía, Jon, Rautemaa-richardson, Riina, Hatzl, Stefan, Maertens, Johan, Debaveye, Yves, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Reisinger, Alexander Christian, Cornely, Oliver A, Lahmer, Tobias, Valerio, Maricela, Delhaes, Laurence, Jabeen, Kauser, Steinmann, Joerg, Chamula, Mathilde, and Bassetti, Matteo

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Letter, Medical mycology, Coronavirus disease 2019 (COVID-19), business.industry, Critically ill, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pain medicine, Critical Illness, MEDLINE, Humans, Registries, COVID-19, Mycology, Critical Care and Intensive Care Medicine, Anesthesiology, Medicine, business, Intensive care medicine
Published
2021
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17. Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Author

Ceulemans, Laurens J, primary, Van Slambrouck, Jan, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Ceuterick, Vincent, additional, Verleden, Stijn E, additional, Vanstapel, Arno, additional, Desmet, Stefanie, additional, Maes, Piet, additional, Van Ranst, Marc, additional, Lormans, Piet, additional, Meyfroidt, Geert, additional, Neyrinck, Arne P, additional, Vanaudenaerde, Bart M, additional, Van Wijngaerden, Eric, additional, Bos, Saskia, additional, Godinas, Laurent, additional, Carmeliet, Peter, additional, Verleden, Geert M, additional, Van Raemdonck, Dirk E, additional, and Vos, Robin, additional

Published
2021
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18. Pulmonary Aspergillosis in Critically Ill Coronavirus Disease 2019 Patients– A Multinational Observational Study by the European Confederation of Medical Mycology

Author

Prattes, Juergen, primary, Wauters, Joost, additional, Giacobbe, Daniele Roberto, additional, Salmanton-Garcia, Jon, additional, Maertens, Johan, additional, Bourgeois, Marc, additional, Reynders, Marijke, additional, Rutsaert, Lynn, additional, Van Regenmortel, Niels, additional, Lormans, Piet, additional, Feys, Simon, additional, Reisinger, Alexander Christian, additional, Cornely, Oliver A., additional, Lahmer, Tobias, additional, Valerio, Maricela, additional, Delhaes, Laurence, additional, Jabeen, Kauser, additional, Steinmann, Joerg, additional, Chamula, Mathilde, additional, Bassetti, Matteo, additional, Hatzl, Stefan, additional, Rautemaa-Richardson, Riina, additional, Koehler, Philipp, additional, Lagrou, Katrien, additional, and Hoenigl, Martin, additional

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2021
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19. Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis1.

Author

Janssen, Nico A. F., Nyga, Rémy, Vanderbeke, Lore, Jacobs, Cato, Ergün, Mehmet, Buil, Jochem B., van Dijk, Karin, Altenburg, Josje, Bouman, Catherine S. C., van der Spoel, Hans I., Rijnders, Bart J. A., Dunbar, Albert, Schouten, Jeroen A., Lagrou, Katrien, Bourgeois, Marc, Reynders, Marijke, van Regenmortel, Niels, Rutsaert, Lynn, Lormans, Piet, and Feys, Simon

Subjects
PULMONARY aspergillosis, COHORT analysis, COVID-19, INTENSIVE care units, SCIENTIFIC observation
Abstract

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial.

Author

Vanderbeke, Lore, Janssen, Nico A. F., Bergmans, Dennis C. J. J., Bourgeois, Marc, Buil, Jochem B., Debaveye, Yves, Depuydt, Pieter, Feys, Simon, Hermans, Greet, Hoiting, Oscar, van der Hoven, Ben, Jacobs, Cato, Lagrou, Katrien, Lemiale, Virginie, Lormans, Piet, Maertens, Johan, Meersseman, Philippe, Mégarbane, Bruno, Nseir, Saad, and van Oers, Jos A. H.

Subjects
INFLUENZA, PULMONARY aspergillosis, CRITICALLY ill, INTENSIVE care patients, RESPIRATORY insufficiency, INFLUENZA complications, INFLUENZA prevention, INTENSIVE care units, RESEARCH, HETEROCYCLIC compounds, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, CATASTROPHIC illness, COMPARATIVE studies
Abstract

Purpose: Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduces the incidence of IAPA.Methods: We compared 7 days of intravenous posaconazole (POS) prophylaxis with no prophylaxis (standard-of-care only, SOC) in a randomised, open-label, proof-of-concept trial in patients admitted to an intensive care unit (ICU) with respiratory failure due to influenza (ClinicalTrials.gov, NCT03378479). Adult patients with PCR-confirmed influenza were block randomised (1:1) within 10 days of symptoms onset and 48 h of ICU admission. The primary endpoint was the incidence of IAPA during ICU stay in patients who did not have IAPA within 48 h of ICU admission (modified intention-to-treat (MITT) population).Results: Eighty-eight critically ill influenza patients were randomly allocated to POS or SOC. IAPA occurred in 21 cases (24%), the majority of which (71%, 15/21) were diagnosed within 48 h of ICU admission, excluding them from the MITT population. The incidence of IAPA was not significantly reduced in the POS arm (5.4%, 2/37) compared with SOC (11.1%, 4/36; between-group difference 5.7%; 95% CI - 10.8 to 21.7; p = 0.32). ICU mortality of early IAPA was high (53%), despite rapid antifungal treatment.Conclusion: The higher than expected incidence of early IAPA precludes any definite conclusion on POS prophylaxis. High mortality of early IAPA, despite timely antifungal therapy, indicates that alternative management strategies are required. After 48 h, still 11% of patients developed IAPA. As these could benefit from prophylaxis, differentiated strategies are likely needed to manage IAPA in the ICU. [ABSTRACT FROM AUTHOR]

Published
2021
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21. COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges.

Author

Prattes, Juergen, Koehler, Philipp, Hoenigl, Martin, on behalf of the ECMM-CAPA Study Group, Wauters, Joost, Giacobbe, Daniele Roberto, Lagrou, Katrien, Salmanton-García, Jon, Rautemaa-Richardson, Riina, Hatzl, Stefan, Maertens, Johan, Debaveye, Yves, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Reisinger, Alexander Christian, and Cornely, Oliver A.

Subjects
PULMONARY aspergillosis, COVID-19, MEDICAL microbiology, COMMUNICABLE diseases, COVID-19 treatment, DIAGNOSIS
Abstract

These limitations of variations in early classification and CAPA overestimation where recently overcome by the more conservative 2020 ECMM/ISHAM CAPA consensus definitions. We thank Rouze et al. for the thoughtful remarks [[1]] on our multinational study on pulmonary aspergillosis (CAPA) associated to coronavirus disease 2019 (COVID-19) [[2]]. Importantly our data reflect a real-life scenario with no predefined CAPA screening or fungal diagnostics strategies and despite enrolling prospectively, not all centers had CAPA and non-CAPA patients reported for the entire study period. [Extracted from the article]

Published
2021
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22. Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis1.

Author

Janssen, Nico A. F., Nyga, Rémy, Vanderbeke, Lore, Jacobs, Cato, Ergün, Mehmet, Buil, Jochem B., van Dijk, Karin, Altenburg, Josje, Bouman, Catherine S. C., van der Spoel, Hans I., Rijnders, Bart J. A., Dunbar, Albert, Schouten, Jeroen A., Lagrou, Katrien, Bourgeois, Marc, Reynders, Marijke, van Regenmortel, Niels, Rutsaert, Lynn, Lormans, Piet, and Feys, Simon

Subjects
*PULMONARY aspergillosis, *COHORT analysis, *COVID-19, *INTENSIVE care units, *SCIENTIFIC observation
Abstract

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Zorg op maat van de mens. Ethisch overleg en advies in het ziekenhuis

Author

Anckaert, Luc, Marcelis, Ludo, Waterbley, Patrick, Brabant, Steven, Nagels, Werner, De Kegel, Dirk, Desmet, Stefaan, Lormans, Piet, and Vercruyssen, Wim

Subjects
Medisch Ethisch Comité, Sedatie, Medsiche experimenten, Medische beslissingen bij het levenseinde, Euthahanasiewet, Rechten van de patiënt, Therapiecodering, Palliatieve zorg, Euthanasiestappenolan, Personalisme, Commerciële studies, Wetteksten, Orgaandonatie, Informed consent
Abstract

De medische mogelijkheden in het ziekenhuis kennen een zeer grote explosie. De dringende vraag die zich hierbij stelt, luidt hoe deze kansen kunnen worden afgestemd op het welzijn van de menselijke persoon. Vanuit vijftien jaar ervaring in concreet ethisch overleg in de Medisch-Ethische Commissie willen de auteurs hun doordachte bevindingen presenteren aan een ruimer publiek. Het eigene van dit boek bestaat in het feit dat het geschreven is op het kruispunt tussen theorie en praktijk. Het boek opent met een voorstelling van de werking van een medisch-ethische commissie. Daarna volgt een fundamentele reflectie over het christelijke personalisme dat in de instellingen van de Caritas-koepel wordt gebruikt bij de bespreking van ethische vragen. Vervolgens is er een sectie gewijd aan de vragen bij het levenseinde. Men vindt er een overzicht van de medische beslissingen bij het levenseinde maar ook concrete adviesteksten. Een volgend deel handelt over de patiëntenrechten en over de problematiek van de medische experimenten en de informed consent. Het geheel wordt afgerond met de relevante wetteksten. Dit boek heeft een duidelijk doelpubliek voor ogen: artsen werkzaam in een ziekenhuis, leden van medisch-ethische commissies, huisartsen, maar ook expliciet verpleegkundigen en studenten. ispartof: edition:2e edition: 2e nrpages: 240 status: published

Published
2008

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