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2 results on '"Loretta VanCamp"'

1. Platinum-Induced Filamentous Growth in Escherichia coli

Author

Loretta VanCamp, Barnett Rosenberg, John Hartwick, Jaroslav Drobnik, and Earl Renshaw

Subjects
chemistry.chemical_classification, Bacilli, biology, Cell division, chemistry.chemical_element, biology.organism_classification, medicine.disease_cause, Microbiology, Divalent, Metal, chemistry, Biochemistry, visual_art, visual_art.visual_art_medium, medicine, Platinum, Molecular Biology, Escherichia coli, Cytokinesis, Bacteria
Abstract

Certain group VIIIB transition metal compounds were found to inhibit cell division in Escherichia coli , causing marked filamentous growth. Gram-negative bacilli were the most sensitive to this effect, whereas gram-positive bacilli responded only at near-toxic levels of the metal. None of the cocci tested showed any apparent effect. Cytokinesis (cross-septation) can be initiated by removal or decrease of platinum, but not by treatment with pantoyl lactone, divalent cations, or a temperature of 42 C.

Published
1967

2. Platinum Compounds: a New Class of Potent Antitumour Agents

Author

Virginia H. Mansour, Loretta VanCamp, Barnett Rosenberg, and James E. Trosko

Subjects
Cis dichlorodiammineplatinum, Chemotherapy, Multidisciplinary, endocrine system diseases, Cell division, Chemistry, medicine.medical_treatment, Platinum compounds, Antineoplastic Agents, Pharmacology, medicine.disease, Mice, medicine, Animals, Neoplasm, Platinum binding, Sarcoma, Leukemia L1210, Sarcoma 180, Platinum
Abstract

CERTAIN platinum compounds completely but reversibly iiihibit cell division in Gram-negative rods1–4. These compounds have been tested for antitumour activity and we report some of the preliminary results. The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice.

Published
1969

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