Search

Your search keyword '"Lorenzo-Zuñiga V"' showing total 9 results
Start Over Author "Lorenzo-Zuñiga V"
9 results on '"Lorenzo-Zuñiga V"'

7. Insulin-like growth factor I improves intestinal barrier function in cirrhotic rats

Author

Lorenzo-Zuñiga, V. (V.)

Subjects
Insulin-Like Growth Factor I/therapeutic use, Intestinal Absorption/drug effects, Liver Cirrhosis, Experimental/drug therapy
Abstract

BACKGROUND AND AIMS: In liver cirrhosis, disruption of the intestinal barrier facilitates bacterial translocation and spontaneous bacterial peritonitis. Insulin-like growth factor I (IGF-I) is an anabolic hormone synthesised by hepatocytes that displays hepatoprotective activities and trophic effects on the intestine. The aim of this study was to investigate the effect of IGF-I on intestinal barrier function in cirrhotic rats. METHODS: In rats with carbon tetrachloride induced cirrhosis, we investigated the effect of IGF-I therapy on: (a) portal pressure; (b) intestinal histology and permeability to endotoxin and bacteria; (c) intestinal expression of cyclooxygenase 2 (COX-2) and tumour necrosis factor alpha (TNF-alpha), two factors that influence in a positive and negative manner, respectively, the integrity of the intestinal barrier; (d) intestinal permeability to 3H-mannitol in rats with bile duct ligation (BDL); and (e) transepithelial electrical resistance (TER) of polarised monolayers of rat small intestine epithelial cells. RESULTS: IGF-I therapy reduced liver collagen expression and portal pressure in cirrhotic rats, induced improvement in intestinal histology, and caused a reduction in bacterial translocation and endotoxaemia. These changes were associated with diminished TNF-alpha expression and elevated COX-2 levels in the intestine. IGF-I reduced intestinal permeability in BDL rats and enhanced barrier function of the monolayers of epithelial intestinal cells where lipopolysaccharide (LPS) caused a decrease in TER that was reversed by IGF-I. This effect of IGF-I was associated with upregulation of COX-2 in LPS treated enterocytes. CONCLUSIONS: IGF-I enhances intestinal barrier function and reduces endotoxaemia and bacterial translocation in cirrhotic rats. IGF-I therapy might be useful in the prevention of spontaneous bacterial peritonitis in liver cirrhosis.

Published
2006

8. Efficacy of a multifactorial strategy for bowel preparation in diabetic patients undergoing colonoscopy: a randomized trial.

Author

Alvarez-Gonzalez MA, Flores-Le Roux JA, Seoane A, Pedro-Botet J, Carot L, Fernandez-Clotet A, Raga A, Pantaleon MA, Barranco L, Bory F, and Lorenzo-Zuñiga V

Subjects
Aged, Blood Glucose metabolism, Cecal Neoplasms, Diet, Female, Humans, Intubation, Gastrointestinal, Male, Patient Education as Topic, Prospective Studies, Single-Blind Method, Adenoma diagnosis, Cathartics administration & dosage, Colonoscopy standards, Colorectal Neoplasms diagnosis, Diabetes Mellitus, Type 2 blood, Dietary Fiber administration & dosage, Hypoglycemic Agents administration & dosage, Polyethylene Glycols administration & dosage
Abstract

Background and study aims: Previous studies have reported that diabetes mellitus is an independent risk factor for inadequate bowel preparation. Current guidelines do not recommend a specific preparation for this patient population. The aims of this study were to assess the efficacy, safety, and tolerability of an adapted preparation protocol for colon cleansing in patients with type 2 diabetes mellitus. Patients and methods: This randomized, single-blind, parallel group, superiority trial compared a conventional bowel preparation protocol (CBP) with a diabetes-specific preparation protocol (DSP). The CBP included a low-fiber diet for 3 days followed by a clear liquid diet for 24 hours before colonoscopy. The DSP included a multifactorial strategy combining an educational intervention, a low-fiber diet, and adjustment of blood glucose-lowering agents. All patients received 4 L of a polyethylene glycol solution in a split-dose regimen. The endoscopists were blinded to the preparation protocol. The primary outcome measure was inadequate bowel preparation according to the Boston Bowel Preparation Scale. Secondary outcome measures included hypoglycemic events, tolerability, and acceptability. Results: A total of 150 patients were included in the study (74 CBP and 76 DSP). Both groups were comparable in terms of baseline characteristics. Inadequate bowel cleansing was more frequent following CBP than DSP (20 % vs. 7 %, P  = 0.014; risk ratio 3.1, 95 % confidence interval 1.2 - 8). Only CBP and performance status were independently associated with inadequate bowel preparation. Both preparations were equally tolerated and accepted by patients, and side-effects were similar between the groups. Conclusions: A multifactorial strategy for bowel preparation in patients with diabetes undergoing colonoscopy showed a threefold reduction in the rate of inadequate bowel preparation, with no differences in safety and tolerability compared with conventional preparation., Trial Registration: ClinicalTrials.gov (NCT02300779)., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2016
Full Text
View/download PDF

9. Does methotrexate induce mucosal healing in Crohn's disease?

Author

Mañosa M, Naves JE, Leal C, Cabré E, Moreno V, Lorenzo-Zuñiga V, Boix J, and Domènech E

Subjects
Adult, Aged, Crohn Disease pathology, Female, Humans, Intestinal Mucosa pathology, Male, Young Adult, Crohn Disease drug therapy, Immunosuppressive Agents therapeutic use, Intestinal Mucosa drug effects, Methotrexate therapeutic use, Wound Healing drug effects
Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results