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7 results on '"Lordal, M."'

5. Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans. (Small Intestine)

Author

Schmidt, P.T., Lordal, M., Gazelius, B., and Hellstrom, P.M.

Subjects
Intestine, Small -- Physiological aspects, Substance P -- Physiological aspects, Blood flow -- Physiological aspects, Health, Physiological aspects
Abstract

Background: The two tachykinins substance P and neurokinin A are abundantly present in the gastrointestinal tract. Substance P preferring neurokinin 1 receptors are mainly found in submucosal blood vessels while [...]

Published
2003

6. Genome-wide association identifies multiple ulcerative colitis susceptibility loci (vol 42, pg 332, 2010)

Author

McGovern, DPB, Gardet, A, Torkvist, L, Goyette, P, Essers, J., Taylor, KD, Neale, BM, Ong, RTH, Lagace, C, Li, C, Green, T, Stevens, CR, Beauchamp, C, Fleshner, PR, Carlson, M, D'Amato, M, Halfvarson, J, Hibberd, ML, Lordal, M, Padyukov, L, Andriulli, A, Colombo, E, Latiano, A, Palmieri, O, Bernard, EJ, Deslandres, C, Hommes, DW, de Jong, DJ, Stokkers, PC, Weersma, RK, Sharma, Y, Silverberg, MS, Cho, JH, Wu, J, Roeder, K, Brant, SR, Schumm, LP, Duerr, RH, Dubinsky, MC, Glazer, NL, Haritunians, T, Ippoliti, A, Melmed, GY, Siscovick, DS, Vasiliauskas, EA, Targan, SR, Annese, V, Wijmenga, C, Pettersson, S, Rotter, JI, Xavier, RJ, Daly, MJ, Rioux, JD, Seielstad, M, and Radiation Oncology

Published
2011

7. Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

Author

McGovern, D.P., Gardet, A., Torkvist, L., Goyette, P., Essers, J., Taylor, K.D., Neale, B.M., Ong, R.T., Lagace, C., Li, C., Green, T., Stevens, C.R., Beauchamp, C., Fleshner, P.R., Carlson, M., D'Amato, M., Halfvarson, J., Hibberd, M.L., Lordal, M., Padyukov, L., Andriulli, A., Colombo, E., Latiano, A., Palmieri, O., Bernard, E.J., Deslandres, C., Hommes, D.W., Jong, D.J. de, Stokkers, P.C., Weersma, R.K., Sharma, Y., Silverberg, M.S., Cho, J.H., Wu, J., Roeder, K., Brant, S.R., Schumm, L.P., Duerr, R.H., Dubinsky, M.C., Glazer, N.L., Haritunians, T., Ippoliti, A., Melmed, G.Y., Siscovick, D.S., Vasiliauskas, E.A., Targan, S.R., Annese, V., Wijmenga, C., Pettersson, S., Rotter, J.I., Xavier, R.J., Daly, M.J., Rioux, J.D., Seielstad, M., McGovern, D.P., Gardet, A., Torkvist, L., Goyette, P., Essers, J., Taylor, K.D., Neale, B.M., Ong, R.T., Lagace, C., Li, C., Green, T., Stevens, C.R., Beauchamp, C., Fleshner, P.R., Carlson, M., D'Amato, M., Halfvarson, J., Hibberd, M.L., Lordal, M., Padyukov, L., Andriulli, A., Colombo, E., Latiano, A., Palmieri, O., Bernard, E.J., Deslandres, C., Hommes, D.W., Jong, D.J. de, Stokkers, P.C., Weersma, R.K., Sharma, Y., Silverberg, M.S., Cho, J.H., Wu, J., Roeder, K., Brant, S.R., Schumm, L.P., Duerr, R.H., Dubinsky, M.C., Glazer, N.L., Haritunians, T., Ippoliti, A., Melmed, G.Y., Siscovick, D.S., Vasiliauskas, E.A., Targan, S.R., Annese, V., Wijmenga, C., Pettersson, S., Rotter, J.I., Xavier, R.J., Daly, M.J., Rioux, J.D., and Seielstad, M.

Abstract

01 april 2010, Contains fulltext : 88540.pdf (publisher's version ) (Closed access), Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract with a complex genetic and environmental etiology. In an effort to identify genetic variation underlying ulcerative colitis risk, we present two distinct genome-wide association studies of ulcerative colitis and their joint analysis with a previously published scan, comprising, in aggregate, 2,693 individuals with ulcerative colitis and 6,791 control subjects. Fifty-nine SNPs from 14 independent loci attained an association significance of P < 10(-5). Seven of these loci exceeded genome-wide significance (P < 5 x 10(-8)). After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3). We confirmed association with 14 previously identified ulcerative colitis susceptibility loci, and an analysis of acknowledged Crohn's disease loci showed that roughly half of the known Crohn's disease associations are shared with ulcerative colitis. These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis.

Published
2010

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