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Your search keyword '"Loranc, Eva"' showing total 13 results
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13 results on '"Loranc, Eva"'

1. TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells

Author

Jaiswal, Aruna S, primary, Dutta, Arijit, additional, Srinivasan, Gayathri, additional, Yuan, Yaxia, additional, Zhou, Daohong, additional, Shaheen, Montaser, additional, Sadideen, Doraid T, additional, Kirby, Austin, additional, Williamson, Elizabeth A, additional, Gupta, Yogesh K, additional, Olsen, Shaun K, additional, Xu, Mingjiang, additional, Loranc, Eva, additional, Mukhopadhyay, Pramiti, additional, Pertsemlidis, Alexander, additional, Bishop, Alexander J R, additional, Sung, Patrick, additional, Nickoloff, Jac A, additional, and Hromas, Robert, additional

Published
2023
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2. Figure S5 from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

Author

Zanotto-Filho, Alfeu, primary, Masamsetti, V. Pragathi, primary, Loranc, Eva, primary, Tonapi, Sonal S., primary, Gorthi, Aparna, primary, Bernard, Xavier, primary, Gonçalves, Rosângela Mayer, primary, Moreira, José C.F., primary, Chen, Yidong, primary, and Bishop, Alexander J.R., primary

Published
2023
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3. Data from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

Author

Zanotto-Filho, Alfeu, primary, Masamsetti, V. Pragathi, primary, Loranc, Eva, primary, Tonapi, Sonal S., primary, Gorthi, Aparna, primary, Bernard, Xavier, primary, Gonçalves, Rosângela Mayer, primary, Moreira, José C.F., primary, Chen, Yidong, primary, and Bishop, Alexander J.R., primary

Published
2023
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4. Supplementary figure legends from Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

Author

Zanotto-Filho, Alfeu, primary, Masamsetti, V. Pragathi, primary, Loranc, Eva, primary, Tonapi, Sonal S., primary, Gorthi, Aparna, primary, Bernard, Xavier, primary, Gonçalves, Rosângela Mayer, primary, Moreira, José C.F., primary, Chen, Yidong, primary, and Bishop, Alexander J.R., primary

Published
2023
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5. EWSFLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

Author

Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, and Bishop, Alexander J. R.

Subjects
Transcription (Genetics) -- Health aspects, Ewing's sarcoma -- Genetic aspects, Binding proteins -- Genetic aspects -- Health aspects, RNA -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Aparna Gorthi [1, 2]; July Carolina Romero [1, 2]; Eva Loranc [2]; Lin Cao [2]; Liesl A. Lawrence [1, 2]; Elicia Goodale [2]; Amanda Balboni Iniguez [3, 4]; Xavier [...]

Published
2018
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7. Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

Author

Zanotto-Filho, Alfeu, primary, Rajamanickam, Subapriya, additional, Loranc, Eva, additional, Masamsetti, V. Pragathi, additional, Gorthi, Aparna, additional, Romero, July Carolina, additional, Tonapi, Sonal, additional, Gonçalves, Rosangela Mayer, additional, Reddick, Robert L., additional, Benavides, Raymond, additional, Kuhn, John, additional, Chen, Yidong, additional, and Bishop, Alexander J.R., additional

Published
2018
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8. EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

Author

Gorthi, Aparna, primary, Romero, July Carolina, additional, Loranc, Eva, additional, Cao, Lin, additional, Lawrence, Liesl A., additional, Goodale, Elicia, additional, Iniguez, Amanda Balboni, additional, Bernard, Xavier, additional, Masamsetti, V. Pragathi, additional, Roston, Sydney, additional, Lawlor, Elizabeth R., additional, Toretsky, Jeffrey A., additional, Stegmaier, Kimberly, additional, Lessnick, Stephen L., additional, Chen, Yidong, additional, and Bishop, Alexander J. R., additional

Published
2018
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10. Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

Author

Zanotto-Filho, Alfeu, primary, Masamsetti, V. Pragathi, additional, Loranc, Eva, additional, Tonapi, Sonal S., additional, Gorthi, Aparna, additional, Bernard, Xavier, additional, Gonçalves, Rosângela Mayer, additional, Moreira, José C.F., additional, Chen, Yidong, additional, and Bishop, Alexander J.R., additional

Published
2016
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13. ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasia.

Author

Bishop A, Romero JC, Tonapi S, Parihar M, Loranc E, Miller H, Lawrence L, Bassani N, Robledo D, Cao L, Nie J, Kanda K, Stoja A, Garcia N, Gorthi A, Stoveken B, Lane A, Fan T, Cassel T, Zha S, and Musi N

Abstract

Ataxia telangiectasia (A-T) is a rare genetic disorder characterized by neurological defects, immunodeficiency, cancer predisposition, radiosensitivity, decreased blood vessel integrity, and diabetes. ATM, the protein mutated in A-T, responds to DNA damage and oxidative stress, but its functional relationship to the progressive clinical manifestation of A-T is not understood. CD98HC chaperones cystine/glutamate (x c - ) and cationic/neutral amino acid (y + L) antiporters to the cell membrane, and CD98HC phosphorylation by ATM accelerates membrane localization to acutely increase amino acid transport. Loss of ATM impacts tissues reliant on SLC family antiporters relevant to A-T phenotypes, such as endothelial cells (telangiectasia) and pancreatic α-cells (fatty liver and diabetes) with toxic glutamate accumulation. Bypassing the antiporters restores intracellular metabolic balance both in ATM-deficient cells and mouse models. These findings provide new insight into the long-known benefits of N-acetyl cysteine to A-T cells beyond oxidative stress through removing excess glutamate by production of glutathione., Competing Interests: Declaration of interest The authors declare no competing financial interests.

Published
2024
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