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2. Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—statistical analysis plan for a multicenter randomized controlled trial

Author

Willemsen, Sten P., Knol, Ronny, Brouwer, Emma, van den Akker, Thomas, DeKoninck, Philip L. J., Lopriore, Enrico, Onland, Wes, de Boode, Willem P., van Kaam, Anton H., Nuytemans, Debbie H., Reiss, Irwin K. M., Hutten, G. Jeroen, Prins, Sandra A., Mulder, Estelle E. M., Hulzebos, Christian V., van Sambeeck, Sam J., van der Putten, Mayke E., Zonnenberg, Inge A., te Pas, Arjan B., and Vermeulen, Marijn J.

Published
2024
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4. Birth and the neonatal period

Author

Rob Taal, H., Reiss, Irwin K. M., Lopriore, Enrico, Jaddoe, Vincent W. V., Steegers, Eric A.P., editor, de Groot, Christianne J.M., editor, Hilders, Carina G.J.M., editor, Hoek, Annemieke, editor, Jaddoe, Vincent W.V., editor, Schoenmakers, Sam, editor, and Zweemer, Ronald P., editor

Published
2024
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5. Variations in antenatal management and outcomes in haemolytic disease of the fetus and newborn: an international, retrospective, observational cohort study

Author

de Winter, Derek P, Lopriore, Enrico, Thorup, Emilie, Petersen, Olav Bjørn, Dziegiel, Morten H, Sundberg, Karin, Devlieger, Roland, de Catte, Luc, Lewi, Liesbeth, Debeer, Anne, Houfflin-Debarge, Véronique, Ghesquiere, Louise, Garabedian, Charles, Le Duc, Kévin, Antolin, Eugenia, Mendez, Nieves, Castleman, James, Tse, Wing Ting, Jouannic, Jean-Marie, Maurice, Paul, Currie, Jane, Mullen, Emma, Geerts, Lut, Rademan, Kerry, Khalil, Asma, Poljak, Borna, Prasad, Smriti, Tiblad, Eleonor, Bohlin, Kajsa, Geipel, Annegret, Rath, Johanna, Malone, Fergal, Mackin, David, Yinon, Yoav, Cohen, Stav, Ryan, Greg, Vlachodimitropoulou, Evangelia, Gloning, Karl-Philipp, Verlohren, Stefan, Mayer, Beate, Lanna, Mariano, Faiola, Stefano, Sršen, Tanja Premru, Cerar, Lilijana Kornhauser, Snowise, Saul, Sun, Luming, Otaño, Lucas, Meller, César Hernan, Connors, Ngina K, Saxonhouse, Matthew, Wolter, Aline, Bedei, Ivonne, Klaritsch, Philipp, Jauch, Sarah, da Silva Ribeiro, Eduardo Teixeira, Filho, Fernando Maia Peixoto, Martinez-Portilla, Raigam Jafet, Matias, Alexandra, Abad, Obdulia Alejos, Roca, Juan Parra, Grisi, Ángel Guillermo Alcázar, Navarro, Edgar Juan José Chávez, van der Bom, Johanna G, de Haas, Masja, and Verweij, EJT (Joanne)

Published
2024
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6. Platelet transfusion in neonatal intensive care units of 22 European countries: a prospective observational study

Author

Alsina-Casanova, Miguel, Andersson, Ola, Arias-Llorente, Rosa Patricia, Berenger, Adeline, Bielska, Edyta, Boia, Marioara, Birkenmaier, André, Biros, Jakub, Blanquart, Anne Laure, Boggini, Tiziana, Boileau, Pascal, Bokiniec, Renata, Bresesti, Ilia, Broad, Katherine, Cavallaro, Giacomo, Chauvel, Jennifer, Cseszneki, Borbála, Dani, Carlo, Demová, Klaudia, Dornis, Diana, Duban, Marie-Pierre, Dziadkowiec-Motyl, Karolina, Erzen, Nika, Fanczal, Eszter, Fernández-Castiñeira, Sara, Galuschka, Libusa, Gandaputra, Ellen, García-Muñoz Rodrigo, Fermín, Gebauer, Corinna, Grimault, Hélène, Grund, Kristina, Gsöllpointner, Melanie, Gualdi, Silvia, Guaragni, Brunetta, Hahn, Markus, Haiden, Nadja, Hasmasanu, Monica, Iacob, Daniela, Ivanici, Mihaela, Jernej, Raphaela, Juren, Tomáš, Karcz, Karolina, Kornhauser, Lilijana, Królak-Olejnik, Barbara, Legnevall, Lena, Lehnerer, Verena, Levine, Emmanuelle, Ley, David, Del Carmen López Castillo, María, Magarotto, Mariella, Martini, Silvia, Maruniak-Chudek, Iwona, Moita, Rita, Mosuro, Anjola, Nowicka, Agnieszka, O'Reilly, Daniel, Pantea, Manuela, Pérez-Muñuzuri, Alejandro, Perme, Tina, Picciau, Laura, Pratesi, Simone, Prins, Sandra, Radicioni, Maurizio, Raffaeli, Genny, Roldan-López, Reyes, Roué, Jean-Michel, Węglarz, Beata Rzepecka, Sibrecht, Greta, Snijder, Pauline, Starčević, Mirta, Szántó, Emese, Teixeira, Liliana, Torrejon, Laura, Martí, Lourdes Urquía, Vanbuggenhout, Laurien, Zanetto, Lorenzo, Houben, Nina A.M., Lopriore, Enrico, Fijnvandraat, Karin, Caram-Deelder, Camila, Carrascosa, Marta Aguar, Beuchée, Alain, Brække, Kristin, Cardona, Francesco, Debeer, Anne, Domingues, Sara, Ghirardello, Stefano, Grizelj, Ruza, Hadžimuratović, Emina, Heiring, Christian, Krivec, Jana Lozar, Malý, Jan, Matasova, Katarina, Moore, Carmel Maria, Muehlbacher, Tobias, Szabó, Miklos, Szczapa, Tomasz, Zaharie, Gabriela, de Jager, Justine, Reibel-Georgi, Nora Johanna, New, Helen V., Stanworth, Simon J., Deschmann, Emöke, Roehr, Charles C., Dame, Christof, le Cessie, Saskia, van der Bom, Johanna, and Fustolo-Gunnink, Suzanne

Published
2024
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7. Use and Waste of Reconstituted Whole Blood Exchange Transfusions: An 11-year National Observational Study

Author

de Winter, Derek P., Lopriore, Enrico, Hulzebos, Christian V., Lukens, Michaël V., Klinkspoor, J.H. (Harriët), van Bohemen, Michaela, den Besten, Gijs, de Vooght, Karen M.K., Vrancken, Sabine L.A.G., Trompenaars, Amanda M.P., Hoffmann-Haringsma, Angelique, Péquériaux, N.C.V. (Nathalie), Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J.L.A.M. (Jacqueline), Zant, Janneke C., van Rossem, Maaike C., van Gammeren, A.J. Adriaan, Weerkamp, Floor, Counsilman, Clare E., Knol, F.R. (Rachel), Schiering, I.A.M. (Irene), Dubbink-Verheij, Gerdina H., Verweij, E.J.T. (Joanne), and de Haas, Masja

Published
2024
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9. Supplemental Iron and Recombinant Erythropoietin for Anemia in Infants Born Very Preterm: A Survey of Clinical Practice in Europe

Author

Reibel-Georgi, Nora J., Scrivens, Alexandra, Heeger, Lisanne E., Lopriore, Enrico, New, Helen V., Deschmann, Emöke, Stanworth, Simon J., Carrascosa, Marta Aguar, Brække, Kristin, Cardona, Francesco, Cools, Filip, Farrugia, Ryan, Ghirardello, Stefano, Krivec, Jana Lozar, Matasova, Katarina, Muehlbacher, Tobias, Sankilampi, Ulla, Soares, Henrique, Szabó, Miklós, Szczapa, Tomasz, Zaharie, Gabriela, Roehr, Charles Christoph, Fustolo-Gunnink, Suzanne, and Dame, Christof

Published
2025
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15. European Association of Perinatal Medicine (EAPM), European Board and College of Obstetricians and Gynaecologists (EBCOG), European Midwives Association (EMA). Joint position statement: Substandard and disrespectful care in labour – because words matter

Author

Ayres-de-Campos, Diogo, Louwen, Frank, Vivilaki, Victoria, Benedetto, Chiara, Modi, Neena, Wielgos, Miroslaw, Tudose, Melania-Elena Pop, Timonen, Susanna, Reyns, Marlene, Yli, Branka, Stenback, Pernilla, Nunes, Inês, Yurtsal, Burcu, Vayssière, Christophe, Roth, Georges-Emmanuel, Jonsson, Maria, Bakker, Petra, Lopriore, Enrico, Verlohren, Stefan, and Jacobsson, Bo

Published
2024
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16. EUROPEAN ASSOCIATION OF PERINATAL MEDICINE (EAPM) EUROPEAN MIDWIVES ASSOCIATION (EMA) Joint position statement: Caesarean delivery rates at a country level should be in the 15-20 % range

Author

Ayres-de-Campos, Diogo, Simon, Agnes, Modi, Neena, Tudose, Melania, Saliba, Elie, Wielgos, Miroslaw, Reyns, Marlene, Athanasiadis, Apostolos, Stenback, Pernila, Verlohren, Stefan, Nikolova, Gergana, Lopriore, Enrico, Yurtsal, Burçu, Pellicer, Adelina, Ramenghi, Luca, and Jacobsson, Bo

Published
2024
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23. Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society

Author

Deprest, Jan, Choolani, Mahesh, Chervenak, Frank, Farmer, Diana, Lagrou, Katrien, Lopriore, Enrico, McCullough, Laurence, Olutoye, Olutoyin, Simpson, Lynn, Van Mieghem, Tim, and Ryan, Greg

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Betacoronavirus, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Consensus, Coronavirus Infections, Female, Host Microbial Interactions, Humans, Infant, Newborn, Infection Control, Infectious Disease Transmission, Patient-to-Professional, Infectious Disease Transmission, Vertical, Maternal Health Services, Occupational Health, Pandemics, Patient Safety, Pneumonia, Viral, Pregnancy, Risk Assessment, Risk Factors, SARS-CoV-2, Vertical transmission, Fetal anomaly, Fetal surgery, Fetoscopy, Fetal medicine, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Paediatrics, Reproductive medicine
Abstract

The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. This document aims to review relevant recent information to allow us to optimize prenatal care delivery. We discuss potential modifications to obstetric management and fetal procedures in SARS-CoV2-negative and SARS-CoV2-positive patients with fetal anomalies or disorders. Most fetal therapies are time sensitive and cannot be delayed. If personnel and resources are available, we should continue to offer procedures of proven benefit, acknowledging any fetal and maternal risks, including those to health care workers. There is, to date, minimal, unconfirmed evidence of spontaneous vertical transmission, though it may theoretically be increased with some procedures. Knowing a mother's preoperative SARS-CoV-2 status would enable us to avoid or defer certain procedures while she is contagious and to protect health care workers appropriately. Some fetal conditions may alternatively be managed neonatally. Counseling regarding fetal interventions which have a possibility of additional intra- or postoperative morbidity must be performed in the context of local resource availability. Procedures of unproven benefit should not be offered. We encourage participation in registries and trials that may help us to understand the impact of COVID-19 on pregnant women, their fetuses, and neonates.

Published
2020

24. NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related venous thrombosis

Author

van Ommen, C. Heleen, Bergman, Klasien A., Boerma, Marit, Bouma, Heleen A., Donker, Albertine E., Gouvernante, Melissa, Hulzebos, Christian V., Khandour, Dalila, Knol, Ronny, Raets, Marlou A., Liem, K. Djien, van Lingen, Richard A., van de Loo, Moniek, Lopriore, Enrico, van der Putten, Mayke, Sol, Jeanine J., Suijker, Monique H., Vijlbrief, Daniel C., Visser, Remco, and van Weissenbruch, Mirjam M.

Published
2023
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31. Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study

Author

de Vos, Thijs W, Winkelhorst, Dian, Árnadóttir, Valgerdur, van der Bom, Johanna G, Canals Surís, Carme, Caram-Deelder, Camila, Deschmann, Emöke, Haysom, Helen E, Hverven, Hem Birgit C, Lozar Krivec, Jana, McQuilten, Zoe K, Muñiz-Diaz, Eduardo, Nogués, Núria, Oepkes, Dick, Porcelijn, Leendert, van der Schoot, C Ellen, Saxonhouse, Matthew, Sola-Visner, Martha, Tiblad, Eleonor, Tiller, Heidi, Wood, Erica M, Young, Vanessa, Železnik, Mojca, de Haas, Masja, and Lopriore, Enrico

Published
2022
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33. Storage properties of platelet concentrates from umbilical cord blood prepared using three different methods.

Author

Cortesi, Valeria, Lopriore, Enrico, Cavallaro, Giacomo, Bontekoe, Ido J., van der Meer, Pieter F., Fustolo‐Gunnink, Susanna, Raffaeli, Genny, Ghirardello, Stefano, and Klei, Thomas R. L.

Subjects
*CORD blood, *MEAN platelet volume, *BLOOD platelet transfusion, *PRODUCTION methods, *PHOSPHATIDYLSERINES
Abstract

Background: Thrombocytopenia, common in preterm newborns, may increase bleeding risk and is often treated with transfusions. Recent studies reveal that transfusing platelets at a high threshold worsens outcomes, possibly due to a "developmental mismatch" between adult‐derived platelets and neonatal hemostatic system. Cord blood‐derived platelet concentrates (CBPCs) could be an alternative for newborns. Our study aims to produce and evaluate the quality parameters of CBPCs during storage. Study Design and Methods: Cord blood was collected from placentas after near‐term and full‐term pregnancies. Several production methods were attempted to obtain CBPCs, varying centrifugation settings, filtration, and dilution procedures. Adult‐derived platelet concentrates (PCs) processed with the same methods, and standard PCs from five buffy‐coats were used as controls. Storage tests were performed on days 2, 4–5, 7 from the collection. Results: CBPCs parameters were compared with adult‐derived PCs, and no significant differences were found for mean platelet volume (MPV), swirling, morphology, glucose, lactate, pCO2, and pO2. pH and bicarbonate were lower in CBPCs. Some significant differences between methods in CD62P expression and JC‐1 ratio were observed. Compared with standard PCs, CBPCs showed lower platelet concentration, pH, and JC‐1. Additionally, both in CBPCs as well as in control PCs, the apoptosis marker phosphatidylserine was elevated. Discussion: CBPCs were of comparable quality to control PCs during storage. However, apoptosis markers in both groups were elevated, suggesting processing and storage of low volumes of PCs require further optimization. Also, filtration of low volumes leads to significant platelet loss, an issue that requires remedy. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—study protocol for a multicentre randomised controlled trial

Author

Knol, Ronny, Brouwer, Emma, van den Akker, Thomas, DeKoninck, Philip L. J., Lopriore, Enrico, Onland, Wes, Vermeulen, Marijn J., van den Akker–van Marle, M. Elske, van Bodegom–Vos, Leti, de Boode, Willem P., van Kaam, Anton H., Reiss, Irwin K. M., Polglase, Graeme R., Hutten, G. Jeroen, Prins, Sandra A., Mulder, Estelle E. M., Hulzebos, Christian V., van Sambeeck, Sam J., van der Putten, Mayke E., Zonnenberg, Inge A., Hooper, Stuart B., and te Pas, Arjan B.

Published
2022
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36. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation: the TWIN Cerclage studies

Author

van Gils, Lissa, primary, de Boer, Marjon A, additional, Bosmans, Judith, additional, Duijnhoven, Ruben, additional, Schoenmakers, Sam, additional, Derks, Jan B, additional, Prins, Jelmer R, additional, Al-Nasiry, Salwan, additional, Lutke Holzik, Margo, additional, Lopriore, Enrico, additional, van Drongelen, Joris, additional, Knol, Marieke H, additional, van Laar, Judith O E H, additional, Jacquemyn, Yves, additional, van Holsbeke, Caroline, additional, Dehaene, Isabelle, additional, Lewi, Liesbeth, additional, van der Merwe, Hannes, additional, Gyselaers, Wilfried, additional, Obermann-Borst, Sylvia A, additional, Holthuis, Mayella, additional, Mol, Ben W, additional, Pajkrt, Eva, additional, and Oudijk, Martijn A, additional

Published
2024
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39. Cerebral imaging and neurodevelopmental outcome after entero- and human parechovirus sepsis in young infants.

Author

de Jong, Eveline, Holscher, Herma, Steggerda, Sylke, Van Klink, Jeanine, van Elzakker, Erika, Lopriore, Enrico, Walther, Frans, and Brus, Frank

Subjects
Cerebral imaging, Enterovirus, Human parechovirus, Neurodevelopment, Brain, Child Development, Enterovirus Infections, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Neurodevelopmental Disorders, Neuroimaging, Parechovirus, Picornaviridae Infections, Prospective Studies, Sepsis, Ultrasonography
Abstract

UNLABELLED: Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness. In addition to standard care, we did a cerebral ultrasound and cerebral magnetic resonance imaging (MRI), as well as neurodevelopmental follow-up at 6 weeks and 6 months and Bayley Scale of Infant and Toddler Development 3rd edition (BSID-III) investigation at 1 year of age. Twenty-six infants, 22 with EV and 4 with HPeV, were analysed. No abnormalities were detected at cerebral imaging. At 1 year of age, two infants had a moderate delay on both the motor and cognitive scale, one on the cognitive scale only and three others on the gross motor scale only. CONCLUSION: Although our study population, especially the number of HPeV positive infants is small, our study shows that these infants do not seem to develop severe neurodevelopmental delay and neurologic sequelae more often than the normal Dutch population. Follow-up to school age allows for more reliable assessments of developmental outcome and is recommended for further studies to better assess outcome. What is known: • Enterovirus and Human Parechovirus infections are a major cause of sepsis-like illness in young infants. • After intensive care treatment for EV or HPeV infection, white matter abnormalities and neurodevelopmental delay have been described. What is new: • In our medium care population, no abnormalities at cerebral imaging after EV- or HPeV-induced sepsis-like illness have been found. • At 1 year of age, infants who had EV- or HPeV-induced sepsis-like illness do not seem to develop severe neurodevelopmental delay and neurologic sequelae more often than the normal population.

Published
2017

43. Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—statistical analysis plan for a multicenter randomized controlled trial

Author

MS Neonatologie, Willemsen, Sten P., Knol, Ronny, Brouwer, Emma, van den Akker, Thomas, DeKoninck, Philip L.J., Lopriore, Enrico, Onland, Wes, de Boode, Willem P., van Kaam, Anton H., Nuytemans, Debbie H., Reiss, Irwin K.M., Hutten, G. Jeroen, Prins, Sandra A., Mulder, Estelle E.M., Hulzebos, Christian V., van Sambeeck, Sam J., van der Putten, Mayke E., Zonnenberg, Inge A., te Pas, Arjan B., Vermeulen, Marijn J., MS Neonatologie, Willemsen, Sten P., Knol, Ronny, Brouwer, Emma, van den Akker, Thomas, DeKoninck, Philip L.J., Lopriore, Enrico, Onland, Wes, de Boode, Willem P., van Kaam, Anton H., Nuytemans, Debbie H., Reiss, Irwin K.M., Hutten, G. Jeroen, Prins, Sandra A., Mulder, Estelle E.M., Hulzebos, Christian V., van Sambeeck, Sam J., van der Putten, Mayke E., Zonnenberg, Inge A., te Pas, Arjan B., and Vermeulen, Marijn J.

Published
2024

44. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation: The TWIN Cerclage studies

Author

MS Verloskunde, Other research (not in main researchprogram), Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, Oudijk, Martijn A., MS Verloskunde, Other research (not in main researchprogram), Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, and Oudijk, Martijn A.

Published
2024

45. Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation:The TWIN Cerclage studies

Author

Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, Oudijk, Martijn A., Van Gils, Lissa, De Boer, Marjon A., Bosmans, Judith, Duijnhoven, Ruben, Schoenmakers, Sam, Derks, Jan B., Prins, Jelmer R., Al-Nasiry, Salwan, Lutke Holzik, Margo, Lopriore, Enrico, Van Drongelen, Joris, Knol, Marieke H., Van Laar, Judith O.E.H., Jacquemyn, Yves, Van Holsbeke, Caroline, Dehaene, Isabelle, Lewi, Liesbeth, Van Der Merwe, Hannes, Gyselaers, Wilfried, Obermann-Borst, Sylvia A., Holthuis, Mayella, Mol, Ben W., Pajkrt, Eva, and Oudijk, Martijn A.

Abstract

Introduction:Twin pregnancies have a high risk of extreme preterm birth (PTB) at less than 28 weeks of gestation, which is associated with increased risk of neonatal morbidity and mortality. Currently there is a lack of effective treatments for women with a twin pregnancy and a short cervix or cervical dilatation. A possible effective surgical method to reduce extreme PTB in twin pregnancies with an asymptomatic short cervix or dilatation at midpregnancy is the placement of a vaginal cerclage. Methods and analysis: We designed two multicentre randomised trials involving eight hospitals in the Netherlands (sites in other countries may be added at a later date). Women older than 16 years with a twin pregnancy at <24 weeks of gestation and an asymptomatic short cervix of ≤25 mm or cervical dilatation will be randomly allocated (1:1) to both trials on vaginal cerclage and standard treatment according to the current Dutch Society of Obstetrics and Gynaecology guideline (no cerclage). Permuted blocks sized 2 and 4 will be used to minimise the risk of disbalance. The primary outcome measure is PTB of <28 weeks. Analyses will be by intention to treat. The first trial is to demonstrate a risk reduction from 25% to 10% in the short cervix group, for which 194 patients need to be recruited. The second trial is to demonstrate a risk reduction from 80% to 35% in the dilatation group and will recruit 44 women. A cost-effectiveness analysis will be performed from a societal perspective. Ethics and dissemination: This study has been approved by the Research Ethics Committees in the Netherlands on 3/30/2023. Participants will be required to sign an informed consent form. The results will be presented at conferences and published in a peer-reviewed journal. Participants will be informed about the results.

Published
2024

46. Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twins

Author

Todtenhaupt, Pia, Kuipers, Thomas B., Dijkstra, Kyra L., Voortman, Lenard M., Franken, Laura A., Spekman, Jip A., Jonkman, Thomas H., Groene, Sophie G., Roest, Arno Aw, Haak, Monique C., Verweij, EJoanne T., van Pel, Melissa, Lopriore, Enrico, Heijmans, Bastiaan T., van der Meeren, Lotte E., Todtenhaupt, Pia, Kuipers, Thomas B., Dijkstra, Kyra L., Voortman, Lenard M., Franken, Laura A., Spekman, Jip A., Jonkman, Thomas H., Groene, Sophie G., Roest, Arno Aw, Haak, Monique C., Verweij, EJoanne T., van Pel, Melissa, Lopriore, Enrico, Heijmans, Bastiaan T., and van der Meeren, Lotte E.

Abstract

The human umbilical cord (hUC) is the lifeline that connects the fetus to the mother. Hypercoiling of the hUC is associated with pre- and perinatal morbidity and mortality. We investigated the origin of hUC hypercoiling using state-of-the-art imaging and omics approaches. Macroscopic inspection of the hUC revealed the helices to originate from the arteries rather than other components of the hUC. Digital reconstruction of the hUC arteries showed the dynamic alignment of two layers of muscle fibers in the tunica media aligning in opposing directions. We observed that genetically identical twins can be discordant for hUC coiling, excluding genetic, many environmental, and parental origins of hUC coiling. Comparing the transcriptomic and DNA methylation profile of the hUC arteries of four twin pairs with discordant cord coiling, we detected 28 differentially expressed genes, but no differentially methylated CpGs. These genes play a role in vascular development, cell-cell interaction, and axis formation and may account for the increased number of hUC helices. When combined, our results provide a novel framework to understand the origin of hUC helices in fetal development.

Published
2024

47. Enhancing the Retinopathy Of Prematurity Risk Profile Through Placental Evaluation of Maternal and Fetal Vascular Malperfusion

Author

MS Neonatologie, MS Verloskunde, El Emrani, Salma, Jansen, Esther J.S., Goeman, Jelle J., Termote, Jacqueline U.M., Lopriore, Enrico, Schalij-Delfos, Nicoline E., van der Meeren, Lotte E., MS Neonatologie, MS Verloskunde, El Emrani, Salma, Jansen, Esther J.S., Goeman, Jelle J., Termote, Jacqueline U.M., Lopriore, Enrico, Schalij-Delfos, Nicoline E., and van der Meeren, Lotte E.

Published
2024

48. Use and Waste of Reconstituted Whole Blood Exchange Transfusions: An 11-year National Observational Study

Author

Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), de Winter, Derek P, Lopriore, Enrico, Hulzebos, Christian V, Lukens, Michaël V, Klinkspoor, J H, van Bohemen, Michaela, Besten, Gijs den, de Vooght, Karen M K, Vrancken, Sabine L A G, Trompenaars, Amanda M P, Hoffmann-Haringsma, Angelique, Péquériaux, N C V, Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J L A M, Zant, Janneke C, van Rossem, Maaike C, Gammeren, A J Adriaan van, Weerkamp, Floor, Counsilman, Clare E, Knol, F R, Schiering, I A M, Dubbink-Verheij, Gerdina H, Verweij, E J T Joanne, de Haas, Masja, WISE investigators, Centraal Diagnostisch Laboratorium, Other research (not in main researchprogram), de Winter, Derek P, Lopriore, Enrico, Hulzebos, Christian V, Lukens, Michaël V, Klinkspoor, J H, van Bohemen, Michaela, Besten, Gijs den, de Vooght, Karen M K, Vrancken, Sabine L A G, Trompenaars, Amanda M P, Hoffmann-Haringsma, Angelique, Péquériaux, N C V, Andriessen, Peter, Gijzen, Karlijn, van Hillegersberg, J L A M, Zant, Janneke C, van Rossem, Maaike C, Gammeren, A J Adriaan van, Weerkamp, Floor, Counsilman, Clare E, Knol, F R, Schiering, I A M, Dubbink-Verheij, Gerdina H, Verweij, E J T Joanne, de Haas, Masja, and WISE investigators

Published
2024

49. Physiological-Based Cord Clamping:When the Baby Is Ready for Clamping

Author

te Pas, Arjan B., Knol, Ronny, Lopriore, Enrico, van den Akker, Thomas H., Hooper, Stuart B., te Pas, Arjan B., Knol, Ronny, Lopriore, Enrico, van den Akker, Thomas H., and Hooper, Stuart B.

Abstract

Background: The timing of cord clamping has become a focal point for neonatal caregivers due to the promising outcomes associated with delayed cord clamping, which is a simple and cost-effective method to enhance the survival and well-being of preterm infants. While initially the rationale behind delaying clamping was to facilitate increased placental transfusion, research has unveiled additional hemodynamic benefits. Summary: Experimental studies have demonstrated improved circulatory transition when clamping is postponed until the lungs are adequately aerated. This suggests that infants requiring assistance during the transition phase may benefit from stabilization while still attached to the cord. The Aeration, Breathing, and then Clamping (ABC) project aimed to translate these experimental findings into clinical practice. Key Message: In this review, we will discuss the insights gained and lessons learned from the project's implementation.

Published
2024

50. Enhancing the Retinopathy Of Prematurity Risk Profile Through Placental Evaluation of Maternal and Fetal Vascular Malperfusion

Author

El Emrani, Salma, Jansen, Esther J.S., Goeman, Jelle J., Termote, Jacqueline U.M., Lopriore, Enrico, Schalij-Delfos, Nicoline E., van der Meeren, Lotte E., El Emrani, Salma, Jansen, Esther J.S., Goeman, Jelle J., Termote, Jacqueline U.M., Lopriore, Enrico, Schalij-Delfos, Nicoline E., and van der Meeren, Lotte E.

Abstract

PURPOSE. To determine the independent effect of uteroplacental malperfusion on the development of retinopathy of prematurity (ROP). METHODS. This cohort study included 591 neonates with a gestational age (GA) ≤ 32 weeks or birthweight (BW) ≤ 1500 g. Clinical data was retrospectively collected and placentas were prospectively examined for maternal vascular malperfusion (e.g., abruption, infarct, distal villous hypoplasia, ischemia, and decidual necrosis) and fetal vascular malperfusion (e.g., thrombosis, fetal hypoxia, and hydrops parenchyma). The primary outcome was ROP. Secondary outcomes were GA, BW, small for gestational age (SGA), mechanical ventilation duration, postnatal corticosteroids, sepsis, and necrotizing enterocolitis. RESULTS. Maternal vascular malperfusion was associated with higher GA, lower BW, and increased SGA rates, except placental abruption, which was associated with lower SGA rates. Fetal vascular malperfusion was associated with lower BW, increased SGA rates and lower duration of mechanical ventilation. Subgroup analysis of placentas without inflammation showed increased rates of distal villous hypoplasia (44% vs. 31%) and hydrops parenchyma (7% vs. 0%) in neonates with ROP. Multivariate regression analyses revealed three placenta factors to be independently associated with ROP: distal villous hypoplasia (OR = 1.7; 95% CI, 1.0–3.0), severe acute histological chorioamnionitis (OR = 2.1; 95% CI, 1.1–3.9) and funisitis (OR = 1.8; 95% CI, 1.0–3.1). CONCLUSIONS. Placental evaluation of distal villous hypoplasia, severe acute chorioamnionitis and funisitis is a novel and valuable addition to the ROP risk profile. Evaluation of these placental risk factors shortly after birth can aid in identifying high-risk infants in an earlier stage than currently possible.

Published
2024

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