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Your search keyword '"Lopez-Yurda, M. I."' showing total 2 results
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2 results on '"Lopez-Yurda, M. I."'

1. Prognostic significance of age in 5631 patients with Wilms tumour prospectively registered in International Society of Paediatric Oncology (SIOP) 93-01 and 2001

Author

Hol, J. A., primary, Lopez-Yurda, M. I., additional, Van Tinteren, H., additional, Van Grotel, M., additional, Godzinski, J., additional, Vujanic, G., additional, Oldenburger, F., additional, De Camargo, B., additional, Ramírez-Villar, G. L., additional, Bergeron, C., additional, Pritchard-Jones, K., additional, Graf, N., additional, and Van den Heuvel-Eibrink, M. M., additional

Published
2019
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2. Incidence Changes of Human Papillomavirus in Oropharyngeal Squamous Cell Carcinoma and Effects on Survival in the Netherlands Cancer Institute, 1980-2009

Author

Henneman, R., Monsjou, H. S., Verhagen, C. V. M., Marie-Louise van Velthuysen, Ter Haar, N. T., Osse, E. M., Lopez-Yurda, M. I., Balm, A. J. M., Den Brekel, M. W. M., and ACLC (FGw)

Subjects
Head and neck squamous cell carcinoma, oropharynx, human papillomavirus, HNSCC, survival, HPV incidence, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Item does not contain fulltext AIM: Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS: We randomly sampled 158 patients from a cohort of 828 patients with OPSCC stratified by decade (1980-1989, 1990-1999, 2000-2009). Formalin-fixed paraffin-embedded material was tested for HPV DNA by SPF-10 polymerase chain reaction (PCR) and immunohistochemically stained for p16 and p53. RESULTS: DNA from 146 patients was suitable for HPV detection. HPV DNA was detected in 13/47 (28%), 18/47 (38%), and 20/52 (38%) patients in the cohorts of 1980-1989, 1990-1999, and 2000-2009, respectively (p-value for trend=0.269). Lack of further increase during the most recent decade is inconsistent with the rising incidence and higher prevalence reported in other Western countries. Patients with HPV-positive OPSCC had a better survival in spite of higher tumor stage.

Published
2015

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