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9 results on '"Lopez-Nieva, Pilar"'

1. Sirtuin 1 regulation of developmental genes during differentiation of stem cells

Author

Calvanese, Vincenzo, Lara, Ester, Suárez-Álvarez, Beatriz, Dawud, Raed Abu, Vázquez-Chantada, Mercedes, Martínez-Chantar, Maria Luz, Embade, Nieves, López-Nieva, Pilar, Horrillo, Angelica, Hmadcha, Abdelkrim, Soria, Bernat, Piazzolla, Daniela, Herranz, Daniel, Serrano, Manuel, Mato, Jose María, Andrews, Peter W., López-Larrea, Carlos, Esteller, Manel, Fraga, Mario F., and Groudine, Mark T.

Published
2010

2. Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cells

Author

Gonzalez-Sanchez, Laura, primary, Cobos-Fernandez, Maria A, additional, Lopez-Nieva, Pilar, additional, Villa-Morales, Maria, additional, Stamatakis, Konstantinos, additional, Cuezva, Jose M, additional, Marin-Rubio, Jose L, additional, Vazquez-Dominguez, Irene, additional, Gonzalez-Vasconcellos, Iria, additional, Salido, Eduardo, additional, Llamas, Pilar, additional, Lopez-Lorenzo, Jose L, additional, Santos, Javier, additional, and Fernandez-Piqueras, Jose, additional

Published
2019
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4. Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cells.

Author

Gonzalez-Sanchez, Laura, Cobos-Fernandez, Maria A, Lopez-Nieva, Pilar, Villa-Morales, Maria, Stamatakis, Konstantinos, Cuezva, Jose M, Marin-Rubio, Jose L, Vazquez-Dominguez, Irene, Gonzalez-Vasconcellos, Iria, Salido, Eduardo, Llamas, Pilar, Lopez-Lorenzo, Jose L, Santos, Javier, and Fernandez-Piqueras, Jose

Subjects
CELL lines, CELLS, CELL survival, DNA mismatch repair
Abstract

Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeeping gene involved in cytoplasm and mitochondrial metabolism. Here we show that reducing the aconitase activity with fluorocitrate decreases the viability of T-cell lymphoblastic neoplasia cells in correlation to the differential aconitase expression. The consequences of the treatment were evidenced in vitro using T-cell lymphoblastic neoplasia cell lines exhibiting 9p21 deletions and variable levels of ACO1 expression or activity. Similar results were observed in melanoma cell lines, suggesting a true potential for fluorocitrate in different cancer types. Notably, ectopic expression of ACO1 alleviated the susceptibility of cell lines to fluorocitrate and, conversely, knockdown experiments increased susceptibility of resistant cell lines. These findings were confirmed in vivo on athymic nude mice by using tumor xenografts derived from two T-cell lines with different levels of ACO1. Taken together, our results indicate that the non-targeted ACO1 deficiency induced by common deletions exerts a collateral cellular lethality that can be used as a novel therapeutic strategy in the treatment of several types of cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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5. The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

Author

Fernandez, Agustin F., Rosales, Cecilia, Lopez-Nieva, Pilar, Grana, Osvaldo, Ballestar, Esteban, Ropero, Santiago, Espada, Jesus, Melo, Sonia A., Lujambio, Amaia, Fraga, Mario F, Pino, Irene, Javierre, Biola, Carmona, Francisco J., Acquadro, Francesco, Steenbergen, Renske D.M., Snijders, Peter J.F., Meijer, Chris J., Pineau, Pascal, Dejean, Anne, Lloveras, Belen, Capella, Gabriel, Quer, Josep, Buti, Maria, Esteban, Juan-Ignacio, Allende, Helena, Rodriguez-Frias, Francisco, Castellsague, Xavier, Minarovits, Janos, Ponce, Jordi, Capello, Daniela, Gaidano, Gianluca, Cigudosa, Juan Cruz, Gomez-Lopez, Gonzalo, Pisano, David G., Valencia, Alfonso, Angel Piris, Miguel, Bosch, Francesc X., Cahir-McFarland, Ellen, Kieff, Elliott, and Esteller, Manel

Subjects
Nucleotide sequence -- Analysis, Methylation -- Analysis, Cancer -- Genetic aspects, Cancer -- Research, DNA viruses -- Research, Health
Published
2009

8. Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies

Author

Fraga, Mario F., primary, Berdasco, Maria, additional, Ballestar, Esteban, additional, Ropero, Santiago, additional, Lopez-Nieva, Pilar, additional, Lopez-Serra, Lidia, additional, Martín-Subero, José I., additional, Calasanz, Maria J., additional, de Silanes, Isabel Lopez, additional, Setien, Fernando, additional, Casado, Sara, additional, Fernandez, Agustin F., additional, Siebert, Reiner, additional, Stifani, Stefano, additional, and Esteller, Manel, additional

Published
2008
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9. Altered microRNA expression in Rett syndrome.

Author

Urdinguio, Rocio G., Fernandez, Agustin F., Lopez-Nieva, Pilar, Rossi, Simona, Huertas, Dori, Kulis, Marta, Liu, Chang-Gong, Croce, Carlo M., and Calin, George A.

Published
2010

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